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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TUBD1-HEATR6 (FusionGDB2 ID:95380)

Fusion Gene Summary for TUBD1-HEATR6

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBD1-HEATR6
Fusion gene ID: 95380
HgeneTgene
Gene symbol

TUBD1

HEATR6

Gene ID

51174

63897

Gene nametubulin delta 1HEAT repeat containing 6
SynonymsTUBDABC1
Cytomap

17q23.1

17q23.1

Type of geneprotein-codingprotein-coding
Descriptiontubulin delta chaindelta-tubulinHEAT repeat-containing protein 6amplified in breast cancer 1amplified in breast cancer protein 1
Modification date2020031320200313
UniProtAcc.

Q6AI08

Ensembl transtripts involved in fusion geneENST00000325752, ENST00000340993, 
ENST00000346141, ENST00000376094, 
ENST00000394239, ENST00000592426, 
ENST00000539018, ENST00000591611, 
ENST00000585712, ENST00000585976, 
ENST00000184956, 
Fusion gene scores* DoF score16 X 16 X 8=204811 X 10 X 6=660
# samples 2212
** MAII scorelog2(22/2048*10)=-3.21864028647534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/660*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUBD1 [Title/Abstract] AND HEATR6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTUBD1(57968192)-HEATR6(58128338), # samples:2
Anticipated loss of major functional domain due to fusion event.TUBD1-HEATR6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TUBD1-HEATR6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TUBD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HEATR6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1FM-01ATUBD1chr17

57968192

-HEATR6chr17

58128338

-
ChimerDB4BRCATCGA-BH-A1FM-01ATUBD1chr17

57970058

-HEATR6chr17

58128338

-


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Fusion Gene ORF analysis for TUBD1-HEATR6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000325752ENST00000585712TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000325752ENST00000585976TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000340993ENST00000585712TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000340993ENST00000585976TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000346141ENST00000585712TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000346141ENST00000585976TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000376094ENST00000585712TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000376094ENST00000585976TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000394239ENST00000585712TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000394239ENST00000585976TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000592426ENST00000585712TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5CDS-intronENST00000592426ENST00000585976TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5UTR-3CDSENST00000325752ENST00000184956TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-3CDSENST00000340993ENST00000184956TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-3CDSENST00000346141ENST00000184956TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-3CDSENST00000394239ENST00000184956TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-3CDSENST00000539018ENST00000184956TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-3CDSENST00000591611ENST00000184956TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5UTR-3CDSENST00000591611ENST00000184956TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000325752ENST00000585712TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000325752ENST00000585976TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000340993ENST00000585712TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000340993ENST00000585976TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000346141ENST00000585712TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000346141ENST00000585976TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000394239ENST00000585712TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000394239ENST00000585976TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000539018ENST00000585712TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000539018ENST00000585976TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000591611ENST00000585712TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5UTR-intronENST00000591611ENST00000585712TUBD1chr17

57970058

-HEATR6chr17

58128338

-
5UTR-intronENST00000591611ENST00000585976TUBD1chr17

57968192

-HEATR6chr17

58128338

-
5UTR-intronENST00000591611ENST00000585976TUBD1chr17

57970058

-HEATR6chr17

58128338

-
Frame-shiftENST00000325752ENST00000184956TUBD1chr17

57968192

-HEATR6chr17

58128338

-
Frame-shiftENST00000340993ENST00000184956TUBD1chr17

57968192

-HEATR6chr17

58128338

-
Frame-shiftENST00000346141ENST00000184956TUBD1chr17

57968192

-HEATR6chr17

58128338

-
Frame-shiftENST00000394239ENST00000184956TUBD1chr17

57968192

-HEATR6chr17

58128338

-
In-frameENST00000376094ENST00000184956TUBD1chr17

57968192

-HEATR6chr17

58128338

-
In-frameENST00000592426ENST00000184956TUBD1chr17

57968192

-HEATR6chr17

58128338

-
intron-3CDSENST00000376094ENST00000184956TUBD1chr17

57970058

-HEATR6chr17

58128338

-
intron-3CDSENST00000539018ENST00000184956TUBD1chr17

57968192

-HEATR6chr17

58128338

-
intron-3CDSENST00000592426ENST00000184956TUBD1chr17

57970058

-HEATR6chr17

58128338

-
intron-intronENST00000376094ENST00000585712TUBD1chr17

57970058

-HEATR6chr17

58128338

-
intron-intronENST00000376094ENST00000585976TUBD1chr17

57970058

-HEATR6chr17

58128338

-
intron-intronENST00000539018ENST00000585712TUBD1chr17

57968192

-HEATR6chr17

58128338

-
intron-intronENST00000539018ENST00000585976TUBD1chr17

57968192

-HEATR6chr17

58128338

-
intron-intronENST00000592426ENST00000585712TUBD1chr17

57970058

-HEATR6chr17

58128338

-
intron-intronENST00000592426ENST00000585976TUBD1chr17

57970058

-HEATR6chr17

58128338

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000592426TUBD1chr1757968192-ENST00000184956HEATR6chr1758128338-17991731161429437
ENST00000376094TUBD1chr1757968192-ENST00000184956HEATR6chr1758128338-17991731161429437

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000592426ENST00000184956TUBD1chr1757968192-HEATR6chr1758128338-0.0021262660.9978738
ENST00000376094ENST00000184956TUBD1chr1757968192-HEATR6chr1758128338-0.0021262660.9978738

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Fusion Genomic Features for TUBD1-HEATR6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TUBD1-HEATR6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57968192/chr17:58128338)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HEATR6

Q6AI08

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Amplification-dependent oncogene.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUBD1chr17:57968192chr17:58128338ENST00000325752-29143_14957454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57968192chr17:58128338ENST00000340993-28143_14957399.0Nucleotide bindingGTP
HgeneTUBD1chr17:57968192chr17:58128338ENST00000346141-25143_14957200.0Nucleotide bindingGTP
HgeneTUBD1chr17:57968192chr17:58128338ENST00000376094-16143_14957352.0Nucleotide bindingGTP
HgeneTUBD1chr17:57968192chr17:58128338ENST00000394239-28143_14957397.0Nucleotide bindingGTP
HgeneTUBD1chr17:57968192chr17:58128338ENST00000539018-16143_1490238.0Nucleotide bindingGTP
HgeneTUBD1chr17:57968192chr17:58128338ENST00000592426-18143_14957454.0Nucleotide bindingGTP
TgeneHEATR6chr17:57968192chr17:58128338ENST000001849561320315_3257631182.0Compositional biasNote=Poly-Lys
TgeneHEATR6chr17:57968192chr17:58128338ENST000001849561320330_3357631182.0Compositional biasNote=Poly-Glu
TgeneHEATR6chr17:57968192chr17:58128338ENST000001849561320383_3907631182.0Compositional biasNote=Poly-Ser
TgeneHEATR6chr17:57968192chr17:58128338ENST000001849561320159_1987631182.0RepeatNote=HEAT 1
TgeneHEATR6chr17:57968192chr17:58128338ENST000001849561320452_4907631182.0RepeatNote=HEAT 2
TgeneHEATR6chr17:57968192chr17:58128338ENST000001849561320515_5527631182.0RepeatNote=HEAT 3
TgeneHEATR6chr17:57968192chr17:58128338ENST000001849561320558_5957631182.0RepeatNote=HEAT 4


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Fusion Gene Sequence for TUBD1-HEATR6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95380_95380_1_TUBD1-HEATR6_TUBD1_chr17_57968192_ENST00000376094_HEATR6_chr17_58128338_ENST00000184956_length(transcript)=1799nt_BP=173nt
CATGTCAATTGTAACAGTGCAACTTGGTCAGTGTGGCAATCAGATTGGTTTTGAAGTTTTTGATGCTTTGCTTAGTGACTCACACAGTTC
CCAGGGACTCTGCTCTATGAGAGAGAATGAGGCATATCAAGCATCTTGCAAAGAAAGATTCTTCAGTGAGGAGGAGAATGGAGGTGGTGA
TGTTCTGGACTATGATGCTGAACGGTCCTTTACCCAGAGCCCTGCAGAATTCAGAACACCCAACTCTCCAGGCGAGCGCCTGTGATGCCC
TGTCTTCCATCTTGCCAGAGGCCTTCAGCAATCTGCCGAATGACAGGCAGATGCTGTGCATCACAGTGCTGCTCGGGCTGAATGACAGCA
AGAATCGCTTAGTGAAAGCTGCAACTTCACGGGCCCTGGGAGTCTATGTGCTTTTTCCCTGTCTCAGACAGGATGTCATATTTGTTGCAG
ACGCAGCAAATGCAATATTGATGTCACTTGAAGACAAGTCTCTGAATGTTCGAGCCAAAGCAGCCTGGTCCCTGGGCAACCTGACAGACA
CTCTGATTGTCAACATGGAAACACCAGACCCAAGTTTCCAGGAAGAGTTCTCTGGTCTCCTGCTCTTGAAAATGTTACGATCAGCTATAG
AAGCATCCAAGGATAAAGACAAGGTAAAAAGCAATGCAGTCCGGGCCCTTGGAAATTTGCTTCATTTTCTGCAACCCTCTCATATAGAAA
AACCCACATTTGCAGAAATCATTGAGGAGTCTATCCAGGCCCTAATTTCTACTGTTCTAACAGAAGCTGCCATGAAAGTCCGATGGAATG
CTTGTTATGCAATGGGAAATGTATTTAAAAATCCTGCCCTTCCTTTAGGGACAGCCCCATGGACCTCCCAGGCCTACAATGCCCTGACAT
CGGTCGTGACATCATGCAAGAACTTCAAAGTGCGCATCAGATCTGCAGCTGCCCTTTCCGTCCCGGGGAAGAGAGAGCAGTACGGGTCTG
TTGACCAGTATGCTCGGATCTGGAATGCATTGGTCACCGCTTTACAGAAGAGTGAAGACACCATAGACTTTTTGGAATTCAAGTACTGTG
TCAGCCTACGGACCCAAATCTGCCAGGCACTGATTCACCTCTTGAGCTTGGCCAGTGCCTCGGACCTCCCTTGTATGAAAGAAACCCTTG
AACTGAGTGGGAATATGGTCCAGTCCTATATTCTACAGTTTTTAAAATCAGGAGCAGAGGGAGATGACACTGGAGCACCCCACAGCCCAC
AGGAAAGAGACCAGATGGTCAGAATGGCCCTTAAACACATGGGCAGCATCCAGGCACCAACTGGAGACACAGCCAGAAGGGCCATCATGG
GCTTTTTAGAAGAGATCCTGGCCGTTTGTTTTGACTCATCTGGATCACAAGGGGCACTCCCAGGGTTAACAAATCAGTGAAGATCCCACC
ATACTTTCTAGATGTCGAAGGCGGCAGTAGGAAGACCTGAGCTTGAGCATAAGATCTGTGGGATTTCATCTTAGGGGCAGAAACAATCCG
TTCACTATTTATTTAGAATGACTTAGCAGCCATTTAAATTTTCACAGAGGGCTCAACCACCTTTGGAGTGACTCCATAGCACTGGCCATG
GTCAGGGTTGTTGGAACATCTGACCTGTGCATCCAGGAGCCGAGGAGTCAGGTTGTAATACAGGCCAAGCAGACGGGCTTTGAGGGCATT

>95380_95380_1_TUBD1-HEATR6_TUBD1_chr17_57968192_ENST00000376094_HEATR6_chr17_58128338_ENST00000184956_length(amino acids)=437AA_BP=19
MRHIKHLAKKDSSVRRRMEVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAAT
SRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASKDKDKV
KSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNF
KVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSGNMVQS

--------------------------------------------------------------
>95380_95380_2_TUBD1-HEATR6_TUBD1_chr17_57968192_ENST00000592426_HEATR6_chr17_58128338_ENST00000184956_length(transcript)=1799nt_BP=173nt
CATGTCAATTGTAACAGTGCAACTTGGTCAGTGTGGCAATCAGATTGGTTTTGAAGTTTTTGATGCTTTGCTTAGTGACTCACACAGTTC
CCAGGGACTCTGCTCTATGAGAGAGAATGAGGCATATCAAGCATCTTGCAAAGAAAGATTCTTCAGTGAGGAGGAGAATGGAGGTGGTGA
TGTTCTGGACTATGATGCTGAACGGTCCTTTACCCAGAGCCCTGCAGAATTCAGAACACCCAACTCTCCAGGCGAGCGCCTGTGATGCCC
TGTCTTCCATCTTGCCAGAGGCCTTCAGCAATCTGCCGAATGACAGGCAGATGCTGTGCATCACAGTGCTGCTCGGGCTGAATGACAGCA
AGAATCGCTTAGTGAAAGCTGCAACTTCACGGGCCCTGGGAGTCTATGTGCTTTTTCCCTGTCTCAGACAGGATGTCATATTTGTTGCAG
ACGCAGCAAATGCAATATTGATGTCACTTGAAGACAAGTCTCTGAATGTTCGAGCCAAAGCAGCCTGGTCCCTGGGCAACCTGACAGACA
CTCTGATTGTCAACATGGAAACACCAGACCCAAGTTTCCAGGAAGAGTTCTCTGGTCTCCTGCTCTTGAAAATGTTACGATCAGCTATAG
AAGCATCCAAGGATAAAGACAAGGTAAAAAGCAATGCAGTCCGGGCCCTTGGAAATTTGCTTCATTTTCTGCAACCCTCTCATATAGAAA
AACCCACATTTGCAGAAATCATTGAGGAGTCTATCCAGGCCCTAATTTCTACTGTTCTAACAGAAGCTGCCATGAAAGTCCGATGGAATG
CTTGTTATGCAATGGGAAATGTATTTAAAAATCCTGCCCTTCCTTTAGGGACAGCCCCATGGACCTCCCAGGCCTACAATGCCCTGACAT
CGGTCGTGACATCATGCAAGAACTTCAAAGTGCGCATCAGATCTGCAGCTGCCCTTTCCGTCCCGGGGAAGAGAGAGCAGTACGGGTCTG
TTGACCAGTATGCTCGGATCTGGAATGCATTGGTCACCGCTTTACAGAAGAGTGAAGACACCATAGACTTTTTGGAATTCAAGTACTGTG
TCAGCCTACGGACCCAAATCTGCCAGGCACTGATTCACCTCTTGAGCTTGGCCAGTGCCTCGGACCTCCCTTGTATGAAAGAAACCCTTG
AACTGAGTGGGAATATGGTCCAGTCCTATATTCTACAGTTTTTAAAATCAGGAGCAGAGGGAGATGACACTGGAGCACCCCACAGCCCAC
AGGAAAGAGACCAGATGGTCAGAATGGCCCTTAAACACATGGGCAGCATCCAGGCACCAACTGGAGACACAGCCAGAAGGGCCATCATGG
GCTTTTTAGAAGAGATCCTGGCCGTTTGTTTTGACTCATCTGGATCACAAGGGGCACTCCCAGGGTTAACAAATCAGTGAAGATCCCACC
ATACTTTCTAGATGTCGAAGGCGGCAGTAGGAAGACCTGAGCTTGAGCATAAGATCTGTGGGATTTCATCTTAGGGGCAGAAACAATCCG
TTCACTATTTATTTAGAATGACTTAGCAGCCATTTAAATTTTCACAGAGGGCTCAACCACCTTTGGAGTGACTCCATAGCACTGGCCATG
GTCAGGGTTGTTGGAACATCTGACCTGTGCATCCAGGAGCCGAGGAGTCAGGTTGTAATACAGGCCAAGCAGACGGGCTTTGAGGGCATT

>95380_95380_2_TUBD1-HEATR6_TUBD1_chr17_57968192_ENST00000592426_HEATR6_chr17_58128338_ENST00000184956_length(amino acids)=437AA_BP=19
MRHIKHLAKKDSSVRRRMEVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAAT
SRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASKDKDKV
KSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNF
KVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSGNMVQS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TUBD1-HEATR6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TUBD1-HEATR6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TUBD1-HEATR6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource