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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TUBD1-TOM1L1 (FusionGDB2 ID:95390)

Fusion Gene Summary for TUBD1-TOM1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBD1-TOM1L1
Fusion gene ID: 95390
HgeneTgene
Gene symbol

TUBD1

TOM1L1

Gene ID

51174

10040

Gene nametubulin delta 1target of myb1 like 1 membrane trafficking protein
SynonymsTUBDSRCASM
Cytomap

17q23.1

17q22

Type of geneprotein-codingprotein-coding
Descriptiontubulin delta chaindelta-tubulinTOM1-like protein 1src-activating and signaling molecule proteintarget of Myb-like protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000325752, ENST00000340993, 
ENST00000376094, ENST00000394239, 
ENST00000592426, ENST00000591611, 
ENST00000346141, ENST00000539018, 
ENST00000348161, ENST00000536554, 
ENST00000540336, ENST00000572405, 
ENST00000575333, ENST00000445275, 
ENST00000572158, ENST00000574744, 
ENST00000575882, ENST00000570371, 
Fusion gene scores* DoF score16 X 16 X 8=20482 X 2 X 2=8
# samples 222
** MAII scorelog2(22/2048*10)=-3.21864028647534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: TUBD1 [Title/Abstract] AND TOM1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTUBD1(57963444)-TOM1L1(52990027), # samples:3
Anticipated loss of major functional domain due to fusion event.TUBD1-TOM1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTOM1L1

GO:0007165

signal transduction

16479011

TgeneTOM1L1

GO:0031954

positive regulation of protein autophosphorylation

16479011

TgeneTOM1L1

GO:0032147

activation of protein kinase activity

16479011

TgeneTOM1L1

GO:0045839

negative regulation of mitotic nuclear division

16479011

TgeneTOM1L1

GO:2000278

regulation of DNA biosynthetic process

16479011


check buttonFusion gene breakpoints across TUBD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TOM1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6969-01ATUBD1chr17

57963444

-TOM1L1chr17

52990027

+


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Fusion Gene ORF analysis for TUBD1-TOM1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000325752ENST00000348161TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000325752ENST00000536554TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000325752ENST00000540336TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000325752ENST00000572405TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000325752ENST00000575333TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000340993ENST00000348161TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000340993ENST00000536554TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000340993ENST00000540336TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000340993ENST00000572405TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000340993ENST00000575333TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000376094ENST00000348161TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000376094ENST00000536554TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000376094ENST00000540336TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000376094ENST00000572405TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000376094ENST00000575333TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000394239ENST00000348161TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000394239ENST00000536554TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000394239ENST00000540336TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000394239ENST00000572405TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000394239ENST00000575333TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000592426ENST00000348161TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000592426ENST00000536554TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000592426ENST00000540336TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000592426ENST00000572405TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-5UTRENST00000592426ENST00000575333TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000325752ENST00000445275TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000325752ENST00000572158TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000325752ENST00000574744TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000325752ENST00000575882TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000340993ENST00000445275TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000340993ENST00000572158TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000340993ENST00000574744TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000340993ENST00000575882TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000376094ENST00000445275TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000376094ENST00000572158TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000376094ENST00000574744TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000376094ENST00000575882TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000394239ENST00000445275TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000394239ENST00000572158TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000394239ENST00000574744TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000394239ENST00000575882TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000592426ENST00000445275TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000592426ENST00000572158TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000592426ENST00000574744TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5CDS-intronENST00000592426ENST00000575882TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5UTR-3CDSENST00000591611ENST00000570371TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5UTR-5UTRENST00000591611ENST00000348161TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5UTR-5UTRENST00000591611ENST00000536554TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5UTR-5UTRENST00000591611ENST00000540336TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5UTR-5UTRENST00000591611ENST00000572405TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5UTR-5UTRENST00000591611ENST00000575333TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5UTR-intronENST00000591611ENST00000445275TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5UTR-intronENST00000591611ENST00000572158TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5UTR-intronENST00000591611ENST00000574744TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
5UTR-intronENST00000591611ENST00000575882TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
Frame-shiftENST00000376094ENST00000570371TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
Frame-shiftENST00000592426ENST00000570371TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
In-frameENST00000325752ENST00000570371TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
In-frameENST00000340993ENST00000570371TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
In-frameENST00000394239ENST00000570371TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-3CDSENST00000346141ENST00000570371TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-3CDSENST00000539018ENST00000570371TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-5UTRENST00000346141ENST00000348161TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-5UTRENST00000346141ENST00000536554TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-5UTRENST00000346141ENST00000540336TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-5UTRENST00000346141ENST00000572405TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-5UTRENST00000346141ENST00000575333TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-5UTRENST00000539018ENST00000348161TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-5UTRENST00000539018ENST00000536554TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-5UTRENST00000539018ENST00000540336TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-5UTRENST00000539018ENST00000572405TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-5UTRENST00000539018ENST00000575333TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-intronENST00000346141ENST00000445275TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-intronENST00000346141ENST00000572158TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-intronENST00000346141ENST00000574744TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-intronENST00000346141ENST00000575882TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-intronENST00000539018ENST00000445275TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-intronENST00000539018ENST00000572158TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-intronENST00000539018ENST00000574744TUBD1chr17

57963444

-TOM1L1chr17

52990027

+
intron-intronENST00000539018ENST00000575882TUBD1chr17

57963444

-TOM1L1chr17

52990027

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000325752TUBD1chr1757963444-ENST00000570371TOM1L1chr1752990027+14995985321416294
ENST00000340993TUBD1chr1757963444-ENST00000570371TOM1L1chr1752990027+14845835171401294
ENST00000394239TUBD1chr1757963444-ENST00000570371TOM1L1chr1752990027+14225214551339294

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000325752ENST00000570371TUBD1chr1757963444-TOM1L1chr1752990027+0.0010573070.9989427
ENST00000340993ENST00000570371TUBD1chr1757963444-TOM1L1chr1752990027+0.0010325140.9989675
ENST00000394239ENST00000570371TUBD1chr1757963444-TOM1L1chr1752990027+0.0011268240.9988732

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Fusion Genomic Features for TUBD1-TOM1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TUBD1chr1757963443-TOM1L1chr1752990026+1.05E-050.9999895
TUBD1chr1757963443-TOM1L1chr1752990026+1.05E-050.9999895

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TUBD1-TOM1L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57963444/chr17:52990027)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTOM1L1chr17:57963444chr17:52990027ENST00000575882216200_28874578.3333333333334DomainGAT
TgeneTOM1L1chr17:57963444chr17:52990027ENST00000575882216421_42574578.3333333333334MotifSH3-binding
TgeneTOM1L1chr17:57963444chr17:52990027ENST00000575882216460_46374578.3333333333334MotifSH2-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUBD1chr17:57963444chr17:52990027ENST00000325752-39143_149106454.0Nucleotide bindingGTP
HgeneTUBD1chr17:57963444chr17:52990027ENST00000340993-38143_149106399.0Nucleotide bindingGTP
HgeneTUBD1chr17:57963444chr17:52990027ENST00000346141-15143_1490200.0Nucleotide bindingGTP
HgeneTUBD1chr17:57963444chr17:52990027ENST00000376094-26143_149106352.0Nucleotide bindingGTP
HgeneTUBD1chr17:57963444chr17:52990027ENST00000394239-38143_149106397.0Nucleotide bindingGTP
HgeneTUBD1chr17:57963444chr17:52990027ENST00000539018-16143_1490238.0Nucleotide bindingGTP
HgeneTUBD1chr17:57963444chr17:52990027ENST00000592426-28143_149106454.0Nucleotide bindingGTP
TgeneTOM1L1chr17:57963444chr17:52990027ENST0000057588221622_15474578.3333333333334DomainVHS


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Fusion Gene Sequence for TUBD1-TOM1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95390_95390_1_TUBD1-TOM1L1_TUBD1_chr17_57963444_ENST00000325752_TOM1L1_chr17_52990027_ENST00000570371_length(transcript)=1499nt_BP=598nt
AGCTGGAGCGTTCGGTGGACAGTGAGCATGCGTACCATATCTGAAGTTCGTAAATTGAAATTGAACATGCGTAATTAATCTTTCTGAATA
GGAAAAAATATATACACAACAAAACTCTCCGTTTATGGAACATGCGCATTTGTTCTCAGTAAGTTTTTCGTTTTGAAAGTGAGCATGCGC
ATGGTGAGTAGGTTGGTCCGAAGTTTGAACCGGACAGAAGCGCTGGTCGGCGTCTGGCGGTTGTTTTTAGAGGTAATACACCTAGTTTGT
GGCTCAGCATGTCAATTGTAACAGTGCAACTTGGTCAGTGTGGCAATCAGATTGGTTTTGAAGTTTTTGATGCTTTGCTTAGTGACTCAC
ACAGTTCCCAGGGACTCTGCTCTATGAGAGAGAATGAGGCATATCAAGCATCTTGCAAAGAAAGATTCTTCAGTGAGGAGGAGAATGGAG
TTCCAATTGCCCGGGCTGTTCTTGTTGACATGGAACCCAAAGTTATCAATCAAATGCTGTCAAAGGCTGCCCAGTCTGGCCAATGGAAAT
ATGGTCAACATGCATGCTTCTGTCAAAAACAAGGTTCTGGAAACAACTGGGCATATGGCTTATTGACATGTGTGTGCAGAACTGTGGTCC
AAGTTTCCAGTCTCTGATTGTGAAGAAGGAATTTGTTAAAGAGAATTTAGTTAAGCTACTGAATCCCAGATACAACTTGCCATTAGACAT
TCAGAATAGAATCTTGAATTTCATTAAGACTTGGTCACAGGGCTTCCCAGGAGGTGTGGATGTAAGCGAAGTCAAAGAAGTATACCTCGA
CCTGGTTAAGAAAGGCGTTCAGTTTCCTCCCTCAGAAGCAGAGGCTGAAACAGCAAGACAAGAGACTGCTCAAATCTCATCAAATCCTCC
AACATCTGTCCCTACTGCACCAGCTCTTTCTTCTGTAATTGCTCCAAAGAACTCGACTGTTACATTGGTCCCAGAACAGATTGGAAAACT
GCACAGTGAATTGGATATGGTGAAAATGAATGTGCGAGTGATGTCCGCCATATTGATGGAGAATACTCCTGGGTCTGAAAACCATGAAGA
CATAGAGCTTCTGCAGAAACTCTATAAAACAGGTCGGGAGATGCAGGAGAGGATCATGGACCTGCTTGTGGTGGTGGAGAACGAAGATGT
AACTGTTGAGCTAATTCAGGTGAATGAGGATTTGAATAATGCTATCCTTGGATATGAGAGGTTTACTAGAAACCAACAAAGGATTTTGGA
GCAAAATAAGAACCAGAAGGAAGCCACCAATACTACCAGTGAGCCTTCTGCCCCATCTCAAGATCTCCTCGACCTAAGTCCCAGTCCCCG
GATGCCTAGGGCCACTCTGGGAGAACTCAACACCATGAATAATCAACTTTCAGGCTTAAGTAAATAAACACTCAGGTCTTTTCAGACCAG

>95390_95390_1_TUBD1-TOM1L1_TUBD1_chr17_57963444_ENST00000325752_TOM1L1_chr17_52990027_ENST00000570371_length(amino acids)=294AA_BP=20
MEIWSTCMLLSKTRFWKQLGIWLIDMCVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEV
YLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSEN
HEDIELLQKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRILEQNKNQKEATNTTSEPSAPSQDLLDLSP

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>95390_95390_2_TUBD1-TOM1L1_TUBD1_chr17_57963444_ENST00000340993_TOM1L1_chr17_52990027_ENST00000570371_length(transcript)=1484nt_BP=583nt
TGGACAGTGAGCATGCGTACCATATCTGAAGTTCGTAAATTGAAATTGAACATGCGTAATTAATCTTTCTGAATAGGAAAAAATATATAC
ACAACAAAACTCTCCGTTTATGGAACATGCGCATTTGTTCTCAGTAAGTTTTTCGTTTTGAAAGTGAGCATGCGCATGGTGAGTAGGTTG
GTCCGAAGTTTGAACCGGACAGAAGCGCTGGTCGGCGTCTGGCGGTTGTTTTTAGAGGTAATACACCTAGTTTGTGGCTCAGCATGTCAA
TTGTAACAGTGCAACTTGGTCAGTGTGGCAATCAGATTGGTTTTGAAGTTTTTGATGCTTTGCTTAGTGACTCACACAGTTCCCAGGGAC
TCTGCTCTATGAGAGAGAATGAGGCATATCAAGCATCTTGCAAAGAAAGATTCTTCAGTGAGGAGGAGAATGGAGTTCCAATTGCCCGGG
CTGTTCTTGTTGACATGGAACCCAAAGTTATCAATCAAATGCTGTCAAAGGCTGCCCAGTCTGGCCAATGGAAATATGGTCAACATGCAT
GCTTCTGTCAAAAACAAGGTTCTGGAAACAACTGGGCATATGGCTTATTGACATGTGTGTGCAGAACTGTGGTCCAAGTTTCCAGTCTCT
GATTGTGAAGAAGGAATTTGTTAAAGAGAATTTAGTTAAGCTACTGAATCCCAGATACAACTTGCCATTAGACATTCAGAATAGAATCTT
GAATTTCATTAAGACTTGGTCACAGGGCTTCCCAGGAGGTGTGGATGTAAGCGAAGTCAAAGAAGTATACCTCGACCTGGTTAAGAAAGG
CGTTCAGTTTCCTCCCTCAGAAGCAGAGGCTGAAACAGCAAGACAAGAGACTGCTCAAATCTCATCAAATCCTCCAACATCTGTCCCTAC
TGCACCAGCTCTTTCTTCTGTAATTGCTCCAAAGAACTCGACTGTTACATTGGTCCCAGAACAGATTGGAAAACTGCACAGTGAATTGGA
TATGGTGAAAATGAATGTGCGAGTGATGTCCGCCATATTGATGGAGAATACTCCTGGGTCTGAAAACCATGAAGACATAGAGCTTCTGCA
GAAACTCTATAAAACAGGTCGGGAGATGCAGGAGAGGATCATGGACCTGCTTGTGGTGGTGGAGAACGAAGATGTAACTGTTGAGCTAAT
TCAGGTGAATGAGGATTTGAATAATGCTATCCTTGGATATGAGAGGTTTACTAGAAACCAACAAAGGATTTTGGAGCAAAATAAGAACCA
GAAGGAAGCCACCAATACTACCAGTGAGCCTTCTGCCCCATCTCAAGATCTCCTCGACCTAAGTCCCAGTCCCCGGATGCCTAGGGCCAC
TCTGGGAGAACTCAACACCATGAATAATCAACTTTCAGGCTTAAGTAAATAAACACTCAGGTCTTTTCAGACCAGCAGAAGAGCTTGATG

>95390_95390_2_TUBD1-TOM1L1_TUBD1_chr17_57963444_ENST00000340993_TOM1L1_chr17_52990027_ENST00000570371_length(amino acids)=294AA_BP=20
MEIWSTCMLLSKTRFWKQLGIWLIDMCVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEV
YLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSEN
HEDIELLQKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRILEQNKNQKEATNTTSEPSAPSQDLLDLSP

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>95390_95390_3_TUBD1-TOM1L1_TUBD1_chr17_57963444_ENST00000394239_TOM1L1_chr17_52990027_ENST00000570371_length(transcript)=1422nt_BP=521nt
ATCTTTCTGAATAGGAAAAAATATATACACAACAAAACTCTCCGTTTATGGAACATGCGCATTTGTTCTCAGTAAGTTTTTCGTTTTGAA
AGTGAGCATGCGCATGGTGAGTAGGTTGGTCCGAAGTTTGAACCGGACAGAAGCGCTGGTCGGCGTCTGGCGGTTGTTTTTAGAGGTAAT
ACACCTAGTTTGTGGCTCAGCATGTCAATTGTAACAGTGCAACTTGGTCAGTGTGGCAATCAGATTGGTTTTGAAGTTTTTGATGCTTTG
CTTAGTGACTCACACAGTTCCCAGGGACTCTGCTCTATGAGAGAGAATGAGGCATATCAAGCATCTTGCAAAGAAAGATTCTTCAGTGAG
GAGGAGAATGGAGTTCCAATTGCCCGGGCTGTTCTTGTTGACATGGAACCCAAAGTTATCAATCAAATGCTGTCAAAGGCTGCCCAGTCT
GGCCAATGGAAATATGGTCAACATGCATGCTTCTGTCAAAAACAAGGTTCTGGAAACAACTGGGCATATGGCTTATTGACATGTGTGTGC
AGAACTGTGGTCCAAGTTTCCAGTCTCTGATTGTGAAGAAGGAATTTGTTAAAGAGAATTTAGTTAAGCTACTGAATCCCAGATACAACT
TGCCATTAGACATTCAGAATAGAATCTTGAATTTCATTAAGACTTGGTCACAGGGCTTCCCAGGAGGTGTGGATGTAAGCGAAGTCAAAG
AAGTATACCTCGACCTGGTTAAGAAAGGCGTTCAGTTTCCTCCCTCAGAAGCAGAGGCTGAAACAGCAAGACAAGAGACTGCTCAAATCT
CATCAAATCCTCCAACATCTGTCCCTACTGCACCAGCTCTTTCTTCTGTAATTGCTCCAAAGAACTCGACTGTTACATTGGTCCCAGAAC
AGATTGGAAAACTGCACAGTGAATTGGATATGGTGAAAATGAATGTGCGAGTGATGTCCGCCATATTGATGGAGAATACTCCTGGGTCTG
AAAACCATGAAGACATAGAGCTTCTGCAGAAACTCTATAAAACAGGTCGGGAGATGCAGGAGAGGATCATGGACCTGCTTGTGGTGGTGG
AGAACGAAGATGTAACTGTTGAGCTAATTCAGGTGAATGAGGATTTGAATAATGCTATCCTTGGATATGAGAGGTTTACTAGAAACCAAC
AAAGGATTTTGGAGCAAAATAAGAACCAGAAGGAAGCCACCAATACTACCAGTGAGCCTTCTGCCCCATCTCAAGATCTCCTCGACCTAA
GTCCCAGTCCCCGGATGCCTAGGGCCACTCTGGGAGAACTCAACACCATGAATAATCAACTTTCAGGCTTAAGTAAATAAACACTCAGGT

>95390_95390_3_TUBD1-TOM1L1_TUBD1_chr17_57963444_ENST00000394239_TOM1L1_chr17_52990027_ENST00000570371_length(amino acids)=294AA_BP=20
MEIWSTCMLLSKTRFWKQLGIWLIDMCVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEV
YLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSEN
HEDIELLQKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRILEQNKNQKEATNTTSEPSAPSQDLLDLSP

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Fusion Gene PPI Analysis for TUBD1-TOM1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTOM1L1chr17:57963444chr17:52990027ENST00000575882216392_39574.0578.3333333333334GRB2
TgeneTOM1L1chr17:57963444chr17:52990027ENST00000575882216442_44574.0578.3333333333334PIK3R1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TUBD1-TOM1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TUBD1-TOM1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource