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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TUBGCP4-TMEM62 (FusionGDB2 ID:95417)

Fusion Gene Summary for TUBGCP4-TMEM62

Fusion gene summary

Fusion gene information	Fusion gene name: TUBGCP4-TMEM62
	Fusion gene ID: 95417
		Hgene	Tgene
	Gene symbol	TUBGCP4	TMEM62
	Gene ID	27229	80021
	Gene name	tubulin gamma complex associated protein 4	transmembrane protein 62
	Synonyms	76P\|GCP-4\|GCP4\|Grip76\|MCCRP3	-
	Cytomap	15q15.3	15q15.2
	Type of gene	protein-coding	protein-coding
	Description	gamma-tubulin complex component 4gamma tubulin ring complex protein (76p gene)gamma-ring complex protein 76 kDa	transmembrane protein 62
	Modification date	20200327	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000260383, ENST00000399460, ENST00000564079, ENST00000570081,	ENST00000569369, ENST00000260403,
Fusion gene scores	* DoF score	4 X 4 X 4=64	4 X 7 X 4=112
	# samples	5	6
	** MAII score	log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/112*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TUBGCP4 [Title/Abstract] AND TMEM62 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TUBGCP4(43678528)-TMEM62(43452879), # samples:3 TUBGCP4(43678528)-TMEM62(43470805), # samples:3
Anticipated loss of major functional domain due to fusion event.	TUBGCP4-TMEM62 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TUBGCP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TMEM62 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-FJ-A3ZF-01A	TUBGCP4	chr15	43678528	-	TMEM62	chr15	43452879	+
ChimerDB4	BLCA	TCGA-FJ-A3ZF-01A	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+
ChimerDB4	BRCA	TCGA-UU-A93S-01A	TUBGCP4	chr15	43678528	-	TMEM62	chr15	43470805	+
ChimerDB4	BRCA	TCGA-UU-A93S-01A	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470805	+

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Fusion Gene ORF analysis for TUBGCP4-TMEM62

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000260383	ENST00000569369	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470805	+
5CDS-3UTR	ENST00000399460	ENST00000569369	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470805	+
5CDS-3UTR	ENST00000564079	ENST00000569369	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470805	+
5CDS-intron	ENST00000260383	ENST00000569369	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+
5CDS-intron	ENST00000399460	ENST00000569369	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+
5CDS-intron	ENST00000564079	ENST00000569369	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+
Frame-shift	ENST00000260383	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470805	+
Frame-shift	ENST00000399460	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470805	+
Frame-shift	ENST00000564079	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470805	+
In-frame	ENST00000260383	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+
In-frame	ENST00000399460	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+
In-frame	ENST00000564079	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+
intron-3CDS	ENST00000570081	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+
intron-3CDS	ENST00000570081	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470805	+
intron-3UTR	ENST00000570081	ENST00000569369	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470805	+
intron-intron	ENST00000570081	ENST00000569369	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000260383

TUBGCP4

chr15

43678528

ENST00000260403

TMEM62

chr15

43452879

2578

1268

2017

658

ENST00000564079

TUBGCP4

chr15

43678528

ENST00000260403

TMEM62

chr15

43452879

2564

1254

2003

658

ENST00000399460

TUBGCP4

chr15

43678528

ENST00000260403

TMEM62

chr15

43452879

2080

770

1519

502

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000260383	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+	0.001776733	0.99822325
ENST00000564079	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+	0.001729386	0.99827063
ENST00000399460	ENST00000260403	TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452879	+	0.003220843	0.99677914

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Fusion Genomic Features for TUBGCP4-TMEM62

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470804	+	2.50E-06	0.9999975
TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452878	+	7.12E-08	0.9999999
TUBGCP4	chr15	43678528	+	TMEM62	chr15	43470804	+	2.50E-06	0.9999975
TUBGCP4	chr15	43678528	+	TMEM62	chr15	43452878	+	7.12E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TUBGCP4-TMEM62

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:43678528/chr15:43452879)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TMEM62

chr15:43678528

chr15:43452879

ENST00000260403

431_451

394

644.0

Transmembrane

Helical

Tgene

TMEM62

chr15:43678528

chr15:43452879

ENST00000260403

481_501

394

644.0

Transmembrane

Helical

Tgene

TMEM62

chr15:43678528

chr15:43452879

ENST00000260403

527_547

394

644.0

Transmembrane

Helical

Tgene

TMEM62

chr15:43678528

chr15:43452879

ENST00000260403

572_592

394

644.0

Transmembrane

Helical

Tgene

TMEM62

chr15:43678528

chr15:43452879

ENST00000260403

599_619

394

644.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TMEM62

chr15:43678528

chr15:43452879

ENST00000260403

3_23

394

644.0

Transmembrane

Helical

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Fusion Gene Sequence for TUBGCP4-TMEM62

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>95417_95417_1_TUBGCP4-TMEM62_TUBGCP4_chr15_43678528_ENST00000260383_TMEM62_chr15_43452879_ENST00000260403_length(transcript)=2578nt_BP=1268nt
AGTCTCCGCAGAGCCCGGGCGGGAGTAGCTGGTGGACCCCGTTGAGCTGCCGAACTTCCGGGACTCCCCCGCGACCCCTTCCCAGCTTCC
CGTCCGCTCCGCCGCAGCGATTGTCTCGGTGGGTTGATTCGGCACAAACCGCCCGACCCAGGGGCCGGTGCGCGTGTGGAAGGGGAAGCA
CTCCCCTCGTGGTCGCCTGGAGGTGCGCTGGAGGAGGGGGTGACATAACCAGGGACTCGAGGTCCGCCGTGGGAATGATCCACGAACTGC
TCTTGGCTCTGAGCGGGTACCCTGGGTCCATTTTCACCTGGAACAAGCGGAGTGGCCTGCAGGTATCGCAGGACTTCCCTTTCCTCCACC
CCAGTGAGACCAGTGTCCTGAATCGACTCTGCCGGCTCGGCACAGACTATATTCGCTTCACTGAGTTCATTGAACAGTACACGGGCCATG
TGCAACAGCAGGATCACCATCCATCTCAACAGGGCCAAGGTGGGTTACATGGAATCTACCTGCGGGCCTTCTGCACAGGGCTGGATTCTG
TTTTGCAGCCTTATCGCCAAGCACTGCTTGATTTGGAACAAGAGTTCCTGGGTGATCCCCATCTCTCCATATCACATGTCAACTACTTCC
TAGACCAGTTCCAGCTTCTTTTTCCCTCTGTGATGGTTGTAGTAGAACAAATTAAAAGTCAAAAGATTCATGGTTGTCAAATCCTGGAAA
CAGTCTACAAACACAGCTGTGGGGGGTTGCCTCCTGTTCGAAGTGCACTGGAAAAAATCCTGGCCGTTTGTCATGGGGTCATGTATAAAC
AGCTCTCAGCCTGGATGCTCCATGGACTCCTCTTGGACCAGCATGAAGAATTCTTTATCAAACAGGGGCCATCTTCTGGTAATGTCAGTG
CCCAGCCAGAAGAGGACGAGGAGGATCTGGGCATTGGGGGACTGACAGGAAAACAACTGAGAGAACTGCAGGACTTGCGCCTGATTGAGG
AAGAGAACATGCTGGCACCATCTCTGAAGCAGTTTTCCCTACGAGTGGAGATTTTGCCATCCTACATTCCAGTGAGGGTTGCTGAAAAAA
TCCTATTTGTTGGAGAATCTGTCCAGATGTTTGAGAATCAAAATGTGAACCTGACTAGAAAAGGATCCATTTTGAAAAACCAGGAAGACA
CTTTTGCTGCAGAGCTGCACCGTCTCAAGCAGCAGCCACTCTTCAGCTTGGTGGACTTTGAACAGGTGGTGGATCGCATTCGCAGCACTG
TGGCTGAGGATTCTGCTGGAAGAAGTAAGAGTGTTCACCACATATTTTCTGTTCAAGAGAATAATCATCTCAGTTTTGATCCCCTGGCAT
CATTTATTCTCCGTACTGATCACTACATCATGGCCCGGGTCCTTTTTGTGCTGATTGTGCTGAGCCAGCTCACCATTCTCATTATTTTTA
GATATCGAGGATACCCAGAGCTTAAAGAACCTTCAGGGTTTATAAATCTGACCTCATTTTCTCTTCATGTCTTGAGCAAAATAAACATCT
TCTACTATTCTGTGTTGTTGTTGACCCTGTATACAGTGCTGGGTCCATGGTTTTTTGGTGAAATCATTGATGGCAAATTTGGTTGCTGCT
TTTCCTTTGGGATATTTGTTAATGGACATTTCCTACAAGGCAGCATAACATTTATAATTGGAATTCTCCAGCTGGCGTTTTTTAACATCC
CCTTGATGGCTTACATGTGTTGGAGCTTGCTGCAGCGGTGCTTTGGTCACAACTTCAGGTCTCATCTCCATCAAAGAAAATACTTGAAAA
TTATGCCTGTTCACCTACTTATGCTACTGCTGTACATCTGGCAGGTTTATTCCTGCTACTTTCTTTATGCAACATACGGCACCCTAGCTT
TTTTATTCTCCCCTTTGCGGACCTGGTTGACACTGCTGACACCTGTTCTCATTCGTTATGTGTGGACACTGAACTCCACCAAGTTTGGAA
TCTTCATGGTGCAGTTAAAAAGCCACCTGAGCTCCTGAAGGCCATGTCTCACCACTGGCAGCTGGGCAGAAGCCCAGCCTCTGTGTCTGT
AGCCCAGGCCTCTACCCCAGTAGCAGGTGGAGGGCCAGGATTGGTGGGTGAGCTTTAGGGAGCAGCTGCTCGTTTGGAGTCCTGGACGTT
GGAGGGATTACCCACTACTGATACCTGCAGAATGGACTGCAGAAAAGTCTCAAAAATAATGCCTTTATTCCTTCCCTCCCTAAGGAGGCA
AAGAGTTGATTTACCTTTGTGAAGAGAAAACCCTTATCTAGGACATCCACAGGGTAGAGGTTGGGTGTGTGTACGGGAGTGTCTGAGGCC
CAGTGTGTTTTTTAGGGTTACCCCATGTAAAGCACTTACCGCTGTGCTTGGAATTCAGCAGCTGTCAAAGGTGCAATTTCAGGGGCAGGG
AACCTTTGAGGATCTGGGCCCGACCCTCACTACCCCTGAGATATTAGTTCCCAGGCCTGTTTTCCCACAGGATTGTGGGCTCTCTGCTTC

>95417_95417_1_TUBGCP4-TMEM62_TUBGCP4_chr15_43678528_ENST00000260383_TMEM62_chr15_43452879_ENST00000260403_length(amino acids)=658AA_BP=409
MSCRTSGTPPRPLPSFPSAPPQRLSRWVDSAQTARPRGRCACGRGSTPLVVAWRCAGGGGDITRDSRSAVGMIHELLLALSGYPGSIFTW
NKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIEQYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQ
EFLGDPHLSISHVNYFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCHGVMYKQLSAWMLHGLLLDQ
HEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQDLRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQ
NVNLTRKGSILKNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEDSAGRSKSVHHIFSVQENNHLSFDPLASFILRTDHYIMARV
LFVLIVLSQLTILIIFRYRGYPELKEPSGFINLTSFSLHVLSKINIFYYSVLLLTLYTVLGPWFFGEIIDGKFGCCFSFGIFVNGHFLQG
SITFIIGILQLAFFNIPLMAYMCWSLLQRCFGHNFRSHLHQRKYLKIMPVHLLMLLLYIWQVYSCYFLYATYGTLAFLFSPLRTWLTLLT

--------------------------------------------------------------
>95417_95417_2_TUBGCP4-TMEM62_TUBGCP4_chr15_43678528_ENST00000399460_TMEM62_chr15_43452879_ENST00000260403_length(transcript)=2080nt_BP=770nt
ATGGAATCTACCTGCGGGCCTTCTGCACAGGGCTGGATTCTGTTTTGCAGCCTTATCGCCAAGCACTGCTTGATTTGGAACAAGAGTTCC
TGGGTGATCCCCATCTCTCCATATCACATGTCAACTACTTCCTAGACCAGTTCCAGCTTCTTTTTCCCTCTGTGATGGTTGTAGTAGAAC
AAATTAAAAGTCAAAAGATTCATGGTTGTCAAATCCTGGAAACAGTCTACAAACACAGCTGTGGGGGGTTGCCTCCTGTTCGAAGTGCAC
TGGAAAAAATCCTGGCCGTTTGTCATGGGGTCATGTATAAACAGCTCTCAGCCTGGATGCTCCATGGACTCCTCTTGGACCAGCATGAAG
AATTCTTTATCAAACAGGGGCCATCTTCTGGTAATGTCAGTGCCCAGCCAGAAGAGGACGAGGAGGATCTGGGCATTGGGGGACTGACAG
GAAAACAACTGAGAGAACTGCAGGACTTGCGCCTGATTGAGGAAGAGAACATGCTGGCACCATCTCTGAAGCAGTTTTCCCTACGAGTGG
AGATTTTGCCATCCTACATTCCAGTGAGGGTTGCTGAAAAAATCCTATTTGTTGGAGAATCTGTCCAGATGTTTGAGAATCAAAATGTGA
ACCTGACTAGAAAAGGATCCATTTTGAAAAACCAGGAAGACACTTTTGCTGCAGAGCTGCACCGTCTCAAGCAGCAGCCACTCTTCAGCT
TGGTGGACTTTGAACAGGTGGTGGATCGCATTCGCAGCACTGTGGCTGAGGATTCTGCTGGAAGAAGTAAGAGTGTTCACCACATATTTT
CTGTTCAAGAGAATAATCATCTCAGTTTTGATCCCCTGGCATCATTTATTCTCCGTACTGATCACTACATCATGGCCCGGGTCCTTTTTG
TGCTGATTGTGCTGAGCCAGCTCACCATTCTCATTATTTTTAGATATCGAGGATACCCAGAGCTTAAAGAACCTTCAGGGTTTATAAATC
TGACCTCATTTTCTCTTCATGTCTTGAGCAAAATAAACATCTTCTACTATTCTGTGTTGTTGTTGACCCTGTATACAGTGCTGGGTCCAT
GGTTTTTTGGTGAAATCATTGATGGCAAATTTGGTTGCTGCTTTTCCTTTGGGATATTTGTTAATGGACATTTCCTACAAGGCAGCATAA
CATTTATAATTGGAATTCTCCAGCTGGCGTTTTTTAACATCCCCTTGATGGCTTACATGTGTTGGAGCTTGCTGCAGCGGTGCTTTGGTC
ACAACTTCAGGTCTCATCTCCATCAAAGAAAATACTTGAAAATTATGCCTGTTCACCTACTTATGCTACTGCTGTACATCTGGCAGGTTT
ATTCCTGCTACTTTCTTTATGCAACATACGGCACCCTAGCTTTTTTATTCTCCCCTTTGCGGACCTGGTTGACACTGCTGACACCTGTTC
TCATTCGTTATGTGTGGACACTGAACTCCACCAAGTTTGGAATCTTCATGGTGCAGTTAAAAAGCCACCTGAGCTCCTGAAGGCCATGTC
TCACCACTGGCAGCTGGGCAGAAGCCCAGCCTCTGTGTCTGTAGCCCAGGCCTCTACCCCAGTAGCAGGTGGAGGGCCAGGATTGGTGGG
TGAGCTTTAGGGAGCAGCTGCTCGTTTGGAGTCCTGGACGTTGGAGGGATTACCCACTACTGATACCTGCAGAATGGACTGCAGAAAAGT
CTCAAAAATAATGCCTTTATTCCTTCCCTCCCTAAGGAGGCAAAGAGTTGATTTACCTTTGTGAAGAGAAAACCCTTATCTAGGACATCC
ACAGGGTAGAGGTTGGGTGTGTGTACGGGAGTGTCTGAGGCCCAGTGTGTTTTTTAGGGTTACCCCATGTAAAGCACTTACCGCTGTGCT
TGGAATTCAGCAGCTGTCAAAGGTGCAATTTCAGGGGCAGGGAACCTTTGAGGATCTGGGCCCGACCCTCACTACCCCTGAGATATTAGT
TCCCAGGCCTGTTTTCCCACAGGATTGTGGGCTCTCTGCTTCCTTAGTCGGAAGTGTTTTCAACTAATCAAATAAATGAATGAATGATGA

>95417_95417_2_TUBGCP4-TMEM62_TUBGCP4_chr15_43678528_ENST00000399460_TMEM62_chr15_43452879_ENST00000260403_length(amino acids)=502AA_BP=253
MRAFCTGLDSVLQPYRQALLDLEQEFLGDPHLSISHVNYFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKI
LAVCHGVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQDLRLIEEENMLAPSLKQFSLRVEILP
SYIPVRVAEKILFVGESVQMFENQNVNLTRKGSILKNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEDSAGRSKSVHHIFSVQE
NNHLSFDPLASFILRTDHYIMARVLFVLIVLSQLTILIIFRYRGYPELKEPSGFINLTSFSLHVLSKINIFYYSVLLLTLYTVLGPWFFG
EIIDGKFGCCFSFGIFVNGHFLQGSITFIIGILQLAFFNIPLMAYMCWSLLQRCFGHNFRSHLHQRKYLKIMPVHLLMLLLYIWQVYSCY

--------------------------------------------------------------
>95417_95417_3_TUBGCP4-TMEM62_TUBGCP4_chr15_43678528_ENST00000564079_TMEM62_chr15_43452879_ENST00000260403_length(transcript)=2564nt_BP=1254nt
CCGGGCGGGAGTAGCTGGTGGACCCCGTTGAGCTGCCGAACTTCCGGGACTCCCCCGCGACCCCTTCCCAGCTTCCCGTCCGCTCCGCCG
CAGCGATTGTCTCGGTGGGTTGATTCGGCACAAACCGCCCGACCCAGGGGCCGGTGCGCGTGTGGAAGGGGAAGCACTCCCCTCGTGGTC
GCCTGGAGGTGCGCTGGAGGAGGGGGTGACATAACCAGGGACTCGAGGTCCGCCGTGGGAATGATCCACGAACTGCTCTTGGCTCTGAGC
GGGTACCCTGGGTCCATTTTCACCTGGAACAAGCGGAGTGGCCTGCAGGTATCGCAGGACTTCCCTTTCCTCCACCCCAGTGAGACCAGT
GTCCTGAATCGACTCTGCCGGCTCGGCACAGACTATATTCGCTTCACTGAGTTCATTGAACAGTACACGGGCCATGTGCAACAGCAGGAT
CACCATCCATCTCAACAGGGCCAAGGTGGGTTACATGGAATCTACCTGCGGGCCTTCTGCACAGGGCTGGATTCTGTTTTGCAGCCTTAT
CGCCAAGCACTGCTTGATTTGGAACAAGAGTTCCTGGGTGATCCCCATCTCTCCATATCACATGTCAACTACTTCCTAGACCAGTTCCAG
CTTCTTTTTCCCTCTGTGATGGTTGTAGTAGAACAAATTAAAAGTCAAAAGATTCATGGTTGTCAAATCCTGGAAACAGTCTACAAACAC
AGCTGTGGGGGGTTGCCTCCTGTTCGAAGTGCACTGGAAAAAATCCTGGCCGTTTGTCATGGGGTCATGTATAAACAGCTCTCAGCCTGG
ATGCTCCATGGACTCCTCTTGGACCAGCATGAAGAATTCTTTATCAAACAGGGGCCATCTTCTGGTAATGTCAGTGCCCAGCCAGAAGAG
GACGAGGAGGATCTGGGCATTGGGGGACTGACAGGAAAACAACTGAGAGAACTGCAGGACTTGCGCCTGATTGAGGAAGAGAACATGCTG
GCACCATCTCTGAAGCAGTTTTCCCTACGAGTGGAGATTTTGCCATCCTACATTCCAGTGAGGGTTGCTGAAAAAATCCTATTTGTTGGA
GAATCTGTCCAGATGTTTGAGAATCAAAATGTGAACCTGACTAGAAAAGGATCCATTTTGAAAAACCAGGAAGACACTTTTGCTGCAGAG
CTGCACCGTCTCAAGCAGCAGCCACTCTTCAGCTTGGTGGACTTTGAACAGGTGGTGGATCGCATTCGCAGCACTGTGGCTGAGGATTCT
GCTGGAAGAAGTAAGAGTGTTCACCACATATTTTCTGTTCAAGAGAATAATCATCTCAGTTTTGATCCCCTGGCATCATTTATTCTCCGT
ACTGATCACTACATCATGGCCCGGGTCCTTTTTGTGCTGATTGTGCTGAGCCAGCTCACCATTCTCATTATTTTTAGATATCGAGGATAC
CCAGAGCTTAAAGAACCTTCAGGGTTTATAAATCTGACCTCATTTTCTCTTCATGTCTTGAGCAAAATAAACATCTTCTACTATTCTGTG
TTGTTGTTGACCCTGTATACAGTGCTGGGTCCATGGTTTTTTGGTGAAATCATTGATGGCAAATTTGGTTGCTGCTTTTCCTTTGGGATA
TTTGTTAATGGACATTTCCTACAAGGCAGCATAACATTTATAATTGGAATTCTCCAGCTGGCGTTTTTTAACATCCCCTTGATGGCTTAC
ATGTGTTGGAGCTTGCTGCAGCGGTGCTTTGGTCACAACTTCAGGTCTCATCTCCATCAAAGAAAATACTTGAAAATTATGCCTGTTCAC
CTACTTATGCTACTGCTGTACATCTGGCAGGTTTATTCCTGCTACTTTCTTTATGCAACATACGGCACCCTAGCTTTTTTATTCTCCCCT
TTGCGGACCTGGTTGACACTGCTGACACCTGTTCTCATTCGTTATGTGTGGACACTGAACTCCACCAAGTTTGGAATCTTCATGGTGCAG
TTAAAAAGCCACCTGAGCTCCTGAAGGCCATGTCTCACCACTGGCAGCTGGGCAGAAGCCCAGCCTCTGTGTCTGTAGCCCAGGCCTCTA
CCCCAGTAGCAGGTGGAGGGCCAGGATTGGTGGGTGAGCTTTAGGGAGCAGCTGCTCGTTTGGAGTCCTGGACGTTGGAGGGATTACCCA
CTACTGATACCTGCAGAATGGACTGCAGAAAAGTCTCAAAAATAATGCCTTTATTCCTTCCCTCCCTAAGGAGGCAAAGAGTTGATTTAC
CTTTGTGAAGAGAAAACCCTTATCTAGGACATCCACAGGGTAGAGGTTGGGTGTGTGTACGGGAGTGTCTGAGGCCCAGTGTGTTTTTTA
GGGTTACCCCATGTAAAGCACTTACCGCTGTGCTTGGAATTCAGCAGCTGTCAAAGGTGCAATTTCAGGGGCAGGGAACCTTTGAGGATC
TGGGCCCGACCCTCACTACCCCTGAGATATTAGTTCCCAGGCCTGTTTTCCCACAGGATTGTGGGCTCTCTGCTTCCTTAGTCGGAAGTG

>95417_95417_3_TUBGCP4-TMEM62_TUBGCP4_chr15_43678528_ENST00000564079_TMEM62_chr15_43452879_ENST00000260403_length(amino acids)=658AA_BP=409
MSCRTSGTPPRPLPSFPSAPPQRLSRWVDSAQTARPRGRCACGRGSTPLVVAWRCAGGGGDITRDSRSAVGMIHELLLALSGYPGSIFTW
NKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIEQYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQ
EFLGDPHLSISHVNYFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCHGVMYKQLSAWMLHGLLLDQ
HEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQDLRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQ
NVNLTRKGSILKNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEDSAGRSKSVHHIFSVQENNHLSFDPLASFILRTDHYIMARV
LFVLIVLSQLTILIIFRYRGYPELKEPSGFINLTSFSLHVLSKINIFYYSVLLLTLYTVLGPWFFGEIIDGKFGCCFSFGIFVNGHFLQG
SITFIIGILQLAFFNIPLMAYMCWSLLQRCFGHNFRSHLHQRKYLKIMPVHLLMLLLYIWQVYSCYFLYATYGTLAFLFSPLRTWLTLLT

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Fusion Gene PPI Analysis for TUBGCP4-TMEM62

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TUBGCP4-TMEM62

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TUBGCP4-TMEM62

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source