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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TUSC3-HOOK3 (FusionGDB2 ID:95482)

Fusion Gene Summary for TUSC3-HOOK3

check button Fusion gene summary
Fusion gene informationFusion gene name: TUSC3-HOOK3
Fusion gene ID: 95482
HgeneTgene
Gene symbol

TUSC3

HOOK3

Gene ID

7991

84376

Gene nametumor suppressor candidate 3hook microtubule tethering protein 3
SynonymsD8S1992|M33|MRT22|MRT7|MagT2|N33|OST3A|SLC58A2HK3
Cytomap

8p22

8p11.21

Type of geneprotein-codingprotein-coding
Descriptiontumor suppressor candidate 3dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3magnesium uptake/transporter TUSC3mental retardation, non-syndromic, autosomal recessive, 22oligosaccharyl transferase subunit TUSC3oligosaccharylprotein Hook homolog 3h-hook3hHK3hook homolog 3
Modification date2020031320200313
UniProtAcc.

Q86VS8

Ensembl transtripts involved in fusion geneENST00000382020, ENST00000503731, 
ENST00000506802, ENST00000509380, 
ENST00000503191, 		ENST00000524839, 
ENST00000307602, 
Fusion gene scores* DoF score9 X 10 X 7=63014 X 10 X 7=980
# samples 1016
** MAII scorelog2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/980*10)=-2.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUSC3 [Title/Abstract] AND HOOK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTUSC3(15398077)-HOOK3(42819454), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TUSC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HOOK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N5-A4R8-01ATUSC3chr8

15398077

-HOOK3chr8

42819454

+
ChimerDB4UCSTCGA-N5-A4R8-01ATUSC3chr8

15398077

+HOOK3chr8

42819454

+


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Fusion Gene ORF analysis for TUSC3-HOOK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000382020ENST00000524839TUSC3chr8

15398077

+HOOK3chr8

42819454

+
5CDS-intronENST00000503731ENST00000524839TUSC3chr8

15398077

+HOOK3chr8

42819454

+
5CDS-intronENST00000506802ENST00000524839TUSC3chr8

15398077

+HOOK3chr8

42819454

+
5CDS-intronENST00000509380ENST00000524839TUSC3chr8

15398077

+HOOK3chr8

42819454

+
In-frameENST00000382020ENST00000307602TUSC3chr8

15398077

+HOOK3chr8

42819454

+
In-frameENST00000503731ENST00000307602TUSC3chr8

15398077

+HOOK3chr8

42819454

+
In-frameENST00000506802ENST00000307602TUSC3chr8

15398077

+HOOK3chr8

42819454

+
In-frameENST00000509380ENST00000307602TUSC3chr8

15398077

+HOOK3chr8

42819454

+
intron-3CDSENST00000503191ENST00000307602TUSC3chr8

15398077

+HOOK3chr8

42819454

+
intron-intronENST00000503191ENST00000524839TUSC3chr8

15398077

+HOOK3chr8

42819454

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000382020TUSC3chr815398077+ENST00000307602HOOK3chr842819454+139293461601887575
ENST00000506802TUSC3chr815398077+ENST00000307602HOOK3chr842819454+139193361501877575
ENST00000509380TUSC3chr815398077+ENST00000307602HOOK3chr842819454+138712881021829575
ENST00000503731TUSC3chr815398077+ENST00000307602HOOK3chr842819454+138692861001827575

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382020ENST00000307602TUSC3chr815398077+HOOK3chr842819454+0.0003349740.999665
ENST00000506802ENST00000307602TUSC3chr815398077+HOOK3chr842819454+0.0003360040.99966395
ENST00000509380ENST00000307602TUSC3chr815398077+HOOK3chr842819454+0.0003350380.999665
ENST00000503731ENST00000307602TUSC3chr815398077+HOOK3chr842819454+0.0003349320.999665

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Fusion Genomic Features for TUSC3-HOOK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TUSC3chr815398077+HOOK3chr842819453+0.0010907830.99890924
TUSC3chr815398077+HOOK3chr842819453+0.0010907830.99890924

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TUSC3-HOOK3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:15398077/chr8:42819454)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HOOK3

Q86VS8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (PubMed:32073997). {ECO:0000250|UniProtKB:Q8BUK6, ECO:0000269|PubMed:11238449, ECO:0000269|PubMed:17237231, ECO:0000269|PubMed:18799622, ECO:0000269|PubMed:25035494, ECO:0000269|PubMed:32073997}.; FUNCTION: (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHOOK3chr8:15398077chr8:42819454ENST00000307602722462_667205719.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK3chr8:15398077chr8:42819454ENST00000307602722553_718205719.0RegionNote=Required for association with Golgi

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUSC3chr8:15398077chr8:42819454ENST00000382020+11059_18746348.0DomainNote=Thioredoxin
HgeneTUSC3chr8:15398077chr8:42819454ENST00000503731+11159_18746339.3333333333333DomainNote=Thioredoxin
HgeneTUSC3chr8:15398077chr8:42819454ENST00000382020+110218_22146348.0Topological domainCytoplasmic
HgeneTUSC3chr8:15398077chr8:42819454ENST00000382020+110243_27646348.0Topological domainLumenal
HgeneTUSC3chr8:15398077chr8:42819454ENST00000382020+110298_31246348.0Topological domainCytoplasmic
HgeneTUSC3chr8:15398077chr8:42819454ENST00000382020+110334_34846348.0Topological domainLumenal
HgeneTUSC3chr8:15398077chr8:42819454ENST00000382020+11042_19646348.0Topological domainLumenal
HgeneTUSC3chr8:15398077chr8:42819454ENST00000503731+111218_22146339.3333333333333Topological domainCytoplasmic
HgeneTUSC3chr8:15398077chr8:42819454ENST00000503731+111243_27646339.3333333333333Topological domainLumenal
HgeneTUSC3chr8:15398077chr8:42819454ENST00000503731+111298_31246339.3333333333333Topological domainCytoplasmic
HgeneTUSC3chr8:15398077chr8:42819454ENST00000503731+111334_34846339.3333333333333Topological domainLumenal
HgeneTUSC3chr8:15398077chr8:42819454ENST00000503731+11142_19646339.3333333333333Topological domainLumenal
HgeneTUSC3chr8:15398077chr8:42819454ENST00000382020+110197_21746348.0TransmembraneHelical
HgeneTUSC3chr8:15398077chr8:42819454ENST00000382020+110222_24246348.0TransmembraneHelical
HgeneTUSC3chr8:15398077chr8:42819454ENST00000382020+110277_29746348.0TransmembraneHelical
HgeneTUSC3chr8:15398077chr8:42819454ENST00000382020+110313_33346348.0TransmembraneHelical
HgeneTUSC3chr8:15398077chr8:42819454ENST00000503731+111197_21746339.3333333333333TransmembraneHelical
HgeneTUSC3chr8:15398077chr8:42819454ENST00000503731+111222_24246339.3333333333333TransmembraneHelical
HgeneTUSC3chr8:15398077chr8:42819454ENST00000503731+111277_29746339.3333333333333TransmembraneHelical
HgeneTUSC3chr8:15398077chr8:42819454ENST00000503731+111313_33346339.3333333333333TransmembraneHelical
TgeneHOOK3chr8:15398077chr8:42819454ENST00000307602722167_433205719.0Coiled coilOntology_term=ECO:0000255
TgeneHOOK3chr8:15398077chr8:42819454ENST0000030760272210_126205719.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for TUSC3-HOOK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95482_95482_1_TUSC3-HOOK3_TUSC3_chr8_15398077_ENST00000382020_HOOK3_chr8_42819454_ENST00000307602_length(transcript)=13929nt_BP=346nt
GCCTTTCCAGGTCTTCTCCCGGTGAACCGGATGCTCTGTCAGTCTCCTCCTCTGCGTCCTCGGCCGCGGCCCGGGTCCCTCGCAAAGCCG
CTGCCATCCCGGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGTGCGCGGTAGGAGCTGGGCGCGCACGGCTACCG
CGCGTGGAGGAGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCC
CACCGGGAGCTTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGGTTGCAGCATTGCA
GGAAGAGAAAAGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTCAATCAATCTGATTCTATAGAAGACCCTAACAGTCCAGC
AGGAAGAAGGCATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAAACATTCAGACTAGAAGCAGCCAAAGATGATTATCGAAT
ACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGATGAACTGACCACTTTGGCAGATGAAGCTCAGTCTCTGAA
AGATGAGATCGACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAAGGTCAAGTAGAATCTTATAAAAAGAAGCTAGAAGACCT
TGGTGATTTAAGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTATATGCAGAATACTGTCAGTCTAGAGGAAGAGTTAAGAAA
GGCCAACGCAGCGCGAAGTCAACTTGAAACCTACAAGAGACAGGTAGTAGAACTACAAAACAGATTATCCGAAGAATCAAAGAAAGCAGA
TAAACTAGATTTTGAATATAAGCGGCTAAAAGAAAAAGTTGACAGTCTTCAAAAAGAAAAGGACAGGCTGAGAACAGAAAGGGATTCTCT
GAAGGAAACCATTGAAGAGCTTCGTTGTGTACAAGCTCAAGAAGGGCAGCTCACAACACAAGGGTTAATGCCTCTTGGAAGTCAGGAGTC
TTCAGACAGTCTAGCTGCAGAGATTGTTACACCTGAAATCAGGGAGAAACTTATTCGTCTTCAGCATGAGAATAAGATGTTAAAGCTTAA
CCAAGAAGGTTCGGACAATGAAAAAATAGCCTTATTGCAGAGCCTTCTAGATGATGCAAATCTACGCAAGAATGAACTGGAGACAGAGAA
TAGGCTGGTGAATCAAAGACTTCTGGAAGTACAGTCACAAGTTGAAGAATTACAAAAATCTTTACAGGATCAAGGCTCAAAAGCAGAAGA
TTCAGTCCTTCTAAAAAAGAAGCTTGAAGAACATCTAGAGAAGCTGCATGAGGCCAATAATGAACTACAGAAGAAGAGAGCCATTATTGA
AGATCTCGAGCCAAGATTTAACAACAGCTCCTTAAAAATTGAAGAATTACAAGAAGCTTTACGAAAGAAAGAGGAAGAAATGAAGCAAAT
GGAAGAACGATACAAAAAATACTTAGAGAAAGCCAAAAGTGTCATCCGTACTTTAGATCCTAAACAGAATCAAGGAGCAGCACCAGAAAT
ACAAGCTCTTAAAAATCAGCTCCAGGAACGAGACCGACTGTTCCACTCATTAGAGAAAGAATATGAGAAAACAAAGAGTCAGAGAGAGAT
GGAAGAGAAATATATTGTTAGTGCCTGGTACAATATGGGAATGACCCTGCATAAAAAGGCAGCTGAAGATAGACTGGCAAGCACAGGCTC
AGGGCAGTCATTTCTGGCGAGGCAGAGGCAAGCGACCAGCAGCAGAAGATCATACCCAGGCCACGTGCAGCCGGCCACAGCAAGGTAGAG
AAGTTGTGCCGCTCAATCACAGACACCTGCACCCACAACATACTTCTGTTACACACAAGAACATTTCAGGAAACTCAGCCAGCTTATTTT
TTGTTTCTCTTCTATGTCAATACTTAGTGTTTCTCATTTTGAGGACTTTTTCTCTCTCCTGTATCTTTGTTTTAGTTTCTTTGGTTTTTA
TTTTGTAGTCCTTTCAGTTATTTTTAATGTGCCAAAAATTTGTACATGTTCAATTAAAAATGTTGTATAATAGTGTAATACTTTTCTTTG
TATGAAAATGTCCTCTTCTTCAAAGGTATAGGCTTTGTAATGAATTAGATTTTCTGCCAATAATTGATATACAATTTATATTCTTTATTG
TGCCTGTGTGTTACCATGCTAAGAATGTCTTTGTTTAAAGGGAATTAATCTTTTTATGATGTATTAATCTGTGTTTTCAATTGTTTTCCA
AGTACAGTTCAAATAACTTGCATATTTACTATACAAAATGGTTGACAAGTGTTCTTTTTGCAAAGACTTGAATACATTGGCAGAGGTGCT
AATCACATCTTCCCTAAGGCACCTGGAAGAATTATTTGAGGAAAAAATGAGTTTTCACATTGTTTTATAGGAAATTAAATTTGTCCAAAG
ATTTGGAGACTATTTTTAAAACATAAATACATAAAATTTCATTATTTCCTGCTATCTTGTTTGCTGGCAGAAGTGAATGTTTGGTGAGGT
TATTTTGGGATAAATTACAAAAGAAAAAAAATTAGACACTGCATTAATTTCTTGTTCTTTTGGAATATCTTAGTAACTGAGGATCATTTT
CTAACAATGTGGTTGACATACCTTCAGTTGCTTTCCACATCTAAAAGAGTTATCTTTCATATATGTACAAGTTATTGGTAGTCTTATTTT
TGGGCTGTTTGTTGACTTATGCCCCATTTGTTTTACTTGTTCTTTAATATAAACCCTTCCATTTTTTAACAATTCCTAACACTTGATATC
TTAATATCAGTCACTAACATTAGTAACTTCTTGTATGTTATATTATGGCAGATCTCTTTACGTTTTTTCTCACATCTATCTGCTAGTCCA
GGAATTTGTTACTAAATAGATTTTCTTGGATATTTGGTTGCCTCAAAGTGCTTACATTTGTTAACAGATTGTAAACCACATTTATTTACA
TTGATGAATGGGCTGTTGAATAATCATTGTAAAGCACTTTGTATATATAAGGTGCTATATAAGTGTGAAATATCATTCATTTATAAATGA
AATGCCTTCTAACTTTCCATATTGACTTATGTATTTGGTCCCAAATTATATTTAAGTCTTTTTTCTTGCAACGTAGCCCATTTTTTGAAA
GCAAAACATTTCTGAAATTAGGTCATGGTTTTTTTGTTTATTTTTAGGTTAGGTCACTTAATATAGGAGGATGTTTTCTCATGTACTTGC
TATTTGCAAGTTCAGGTTTCATTTGGTTCTTTATGTTAAATACGAATAAGTAACCTCAAATCAAGCTAAATGTAATTAAGAATTTTCAGC
AACTATATTCAAGTGTTTGATTTTTAAATTCTTTCTTTCTTTTTAATAAGAAAGATGACCTAAAAATCAGTGGTATTTGTTTGTCCTCAG
AAGCCGTAGTTGAAGAAAGATATTAGAGTATACACAGAACTGGAGCCATACATTGTGCTAATTTTTTACATTAAGTACAGAAGTCTGAGC
ACAGCATGAATGCTTCTGCCTGACAGGACCACAAAGCAGCAGAAGTTAGGGATAAATGGAGATAGCCATGAGTAGAACTGCTGTAGGGCT
TCAGGAGGCTACGCAGACCTGATCAACTGCAAAGTTTCCAAAGTAAAAGATTAAAAACTTTCAGACGGTTCTTACCTCTACCCGTGTTTC
ACAAATAGCCTGAGGATCCAACTATTTTTAAAGCAAATTGGGGCCAGACGTGGTGCCTCACGCCTGCAATCTCACCATTTGGGAGACCTA
GGTGGGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAATTACAAAAATTAGCT
GGGCATGGTGGCATGTGGCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAGTCACTTGAACTCAGGAGCCAGAGACTGCAGTGAG
CTGAGATCGCACCACTGCATTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAATCAGTCAATCAATCAATCAATCAAATTGGAATATG
AGCACTAACCTTGGTAAGTTAAAATTTTGGGAAAATTGTACCTGCAGAATATGATGGATGAAAACAACAGCCAGGTGCAGTGGCTCACGC
GTATAATCCCAGCACTTTGGGAGGCCGAGACAGGCACATCATCTGAGGTCAGGACTTCCAGACCAGCCTGTCCAACATGGTGAAACTCCG
TCTCTACTAAAAATACAAACAATTAGCCAGGCATGGTGGTGTGTGCCTGTAGTCCCAGCTACTTGGGAGGGTGAGGCAGGAGAATTGCTT
GAACCTGGGAGACAGAGATTGCAGTGAGCCGAGATGGCGCCATTGCACCCCAGCCTGGCGACAAGAGCGAAACTCTGTCGCAAGAAAAAA
AAAAAAAAAAAAAAAAAAAAAAACAGTCTGTGAACTACTCACTGAATGAATTTTGTTCTGTGAGATGAGAGGTTTTCATTTTCATTTTCT
ATTTACAGCCCCAGTCCTAATCTCCTACCCATCCACCTACCCAGATATTTTTTCTCTATCTGGGTTGGAAAGGCCCCAGGCTTTTAGAGG
GGAGTTTTACTTCTGACTTTTTTTTCCCCCCGAGACGGAGCCTCGTTCCGTCACCCAGGCTGTAGTGCCGTGGCATGATCTCGGCTCACT
GCAGCCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGTGCCCACCACCATGGCTGGCTAA
TTTTTGTAATTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCGTGATCTACCCACCTCGGCCTCCC
AAAGTGCTGAGATTACAGGCACGAGCCACCGCGCCCAGTCGTACTTCTGACTTTTCTTCAGCATCTGTTGTATGCTATTATTTTGATGTT
TACATTTATAATTTTCTTTCTTTTTTTTTTTTTTGTGAGATGATGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCGGC
TCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCGGGGACTACAGGCGCCCGCCACTACGCCCG
ACTAATTTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCGCCTC
AGCCTCCCAGAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTACATTTATAATTTTCATTCTCTTTTACCTATAAAATTCAGT
GTATTAGTTTCATTACATAGGAGAAATTATATTTCTAAACATTTTATGATGTTTAAAAACAAAACAGGCTGTTGTAAAAAAAAAAAAAAA
AAAAACTTCTGAATATACTTTAGGTATCAGAAAGCCAAGAATAAAATTTAGCTCTAACGGTGGCAACTCCATGTCCGGTGTCCAGCTTTG
GACAGGGTTTATGACGTTTCTGTTTCTCTAGTAATGATTAATGATTCCTCAGGAGATTCGTGATGTTGTCTGGTCTATCTGGAAATTTAA
AGTCACTAGGAGCTTTGCCTCATCGTGAGTGATGCTGTGCTGTATTTTTACAAACTCTCGCATACAGCACCTTCCTGGGGCCACGTTGGC
TTGTGCAGTGGAGCTTGTCCAGGCACCAGCATGGAGCAAGTACAGGGTTGCTGTGTTGGGTTGGAGCACACTGTCACCACAGTGTCTGAA
GTCTTATAAACAGGAAGATCATTTTCTGTTTTCCTTCTAACCAGGGTGAGAAAATACAAAGTAAAGAACTAAAGAATATTAAAACCTAGC
ATTTATGTTCCACAGTGTGTATTTCAGAAGTTTGTAATCCAGAAAATATAGTAGTGTATAATATCTGAAAAGAGAATCAAGTATACAATT
GTACATATTTTTAAAGAACTTTGAAAAACTCCGTCATATCTTTTACCATTTGTCTATTTGATAGTAATGCAGAAAAAAGTCCCTAAAGAC
CCTGTGTTCCAAAATTTACCAAGATTGACATTTCTATTAGACATCCTTAACCTAAGTGTTTTAATTAGATTATTAGACTATAATAAGGAT
GAAATTGCTGTCTGTAATTTTGTTGAGGTTTTATTGTTAATATAATAAAAGCTCAACTGTACAAAATTAAGCTAAATGTTATCCAGTCAG
AAACATCAGCCTGTGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGA
GTTCAAGACCAGCCTGGCTAATATGGTGAAACCCCATCTCTACTAAAAATACAGTATTAGCCAGGCATGGTGGCAGGCGCCTGTGATCCC
AGCTACTTGGGAGGCTGAGGCAGGAGAATCATGTGAACCCAGGAGGTGGAGGTTGCAGTAAGCCGAGATTGTGCCACTGCACTCCAGCCT
GGGCCACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAGAAACATCAGCCTGTATATTCCAGTAGTTCTCACAGAAGAAT
GAAAATCCGTGCTGTGCAAATAGATCAGTAGTGAGTGAGTGTTAAGTGAAAGATGAGCTAGGTTGAAGAAAATATACATTTTATTGATGA
GCCACTTTGCTATCTCTCCTTCCTTCCTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCCTTCTTTTCTTTTTTCTTTTCTTTTCTT
TTCTCCCTCCTTTCTTCCTTCCCTTCCCTTCCCCTCCCCTCCCCCAGGCTGGAGTGCAGAGGCACGATCCTGGCTGACTGCAAACTCTGC
CTACCAGGTTCAAGCGATTCTCCTGCCTCATCCTCCCTAGTAGCTAGGATTACAGGCATCTGCCACCACGCCCAGCTAATTTTTGTATTT
TTACAAAATACAAAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAACTCCTGACCTCAGGTGATCCGTCCACCTTGGCCTCCC
AAAGTGCTGGGATTACAGGCGTGTGTTACTGCCCCAGCCTCCTATTTCCTTTTCGAAAGTAGCAGTTTGGTTTATTCTCGTTTGCTAAGT
AATTGTTTGAAATATTTTTCAGCCTCTCCTGCTCCCTCACAAAAATTCACCTGTCATTTTAATGATAACAGCATGTTAAAAACTTGGAAG
TCTTTATCCCAATATAAGAATTATCTTGAAACAAAAATCTAAATTACTTTTAAAAATTCTCTTAACTCTGCATTTAGTCTCCTATTATCT
AGATCTCTGAGTCCAGGATAACTCCAGTTATCCCCAGTTGGATCATGTGTGATTTATCTGAGAAAGCATCCACAACCCACAGCTAGTGGA
AACCGAGCTAGTTTACAGCCACGTGGATAAGAACATCTTTGTTTCTAAAGTGAGAGGAAAGTGCTTGGTATCTTGCTTTTTGCTGAGGGC
AAAATAACAACATGAAGACAAAGTGCTTTTTGTTGTCTATTCATGAAACTGTAGAAGAATATTTTGAGTTTTTATTCTTATATTATGAAG
GGATTCTTTGCCTAGCAGTGGCCGTCAAACTGATGTAGCATTGTACTTCTCAACAGTGAAGCCTGTGTAATACCATACAGTAGGATGAAA
GACTATTCTGAGCAAAATCAAATGGGATGTCAGAATCTTTGAAAATTATTTTATCATTTTTTCTATTTTTTCATTTTTATAAATTAGAAG
GATTTTCCATTCAATAAGGATAATCTCTCTTCCTATCATTCTGTCAAAATGGCAGTTTCTTTTGGTAATTATCCAACCTAGTTTCATTAC
ATTTAGAAGGAGGTTTCAGAGCTTATTCTTGATAACTATAATAATGATTTGAATGTTTTATATCATGAAGTTTTTTCTATGAGGAAGGCT
ATTCTCAATGTATCTGTCGTCTAATTTTTTATTTTCTATCTATAAAGAATATTTAAATAATAATTGGTGTATGTTCCTTTTGTTGAAAAT
GTTTTATTGTCCAGTTTTAACACAGAAGTGGTCTAAAGTTTTGCAGCAAATGCTGTTCAGTTCCCAGAAGCCTAAAAAACATAACATAAT
ATGCTAACAGAGCTAATTTCCACCCAATCCCTCAAATTACCGAAGTATTAATATTTAGCTTCCTTTCTAGAAAACAAGGGGCAGCACAAA
TGGGGTGGCATCCATCTCTTTTAAATCACTGATGATTTTCTGGGGAAGTATATATAGATGATTTTATTTTTTAAATAGCCTTTTATCAAA
CCATTTCACATGTATTATCTATATGACTATAGAAACTTATAAAACATTTAATTCATGTTGACTTAAAACATGGGCATCCTTGGATTCTCC
ACATTGACTGAAATGATAGAGAAAGGGACATTTGTTTGAGAAACAAGAGACCTGTACCTAATTATGGCAAGTATATGAGTTTTGGTGATT
GTGGGGGGTTATAAATGTTTTCCTATGATAGATAAATATATAGATATAGATCAGGAATTACTTGATGTCTCTTCAGAAGTTTTCTGTTTT
CTTATAATTTCCAGTAATACTCTGTAAGACTCGGTTTGCATGCTGTGTGTGTTTGCATGAGTATAGAAACCTAAGAACATAATGGAAGGC
TATTAAGGCAAATTCATTCCTAGAAAGTGGAGTGGATCATTGGGATAAGAAATAGCCTAATTATAAACAAATATGCAGGCAGAGGGAAGT
CCTAATACAATGAAAACTTGCATTATCTAAACAGATGTTCCCAAAGCAATAGTTTGCCTAAAATCCTCTGTATTACATGATTATTCAGTA
AAAGAGTAAACAAATATCTAATTTATTTTCTAATTGTCCTTCCCTTCATTGAGTATTAACTAGGTGCATAATGTAGTTGTATATGTTTAC
TAGTAAAGGGAAAAACACTTATTTTCATTTTGAGACTGTTTGGCTATTACTAAAGCTGAGAAAGTGATTTTAGGTCGCCAAGGATACTAT
GATTTGATGAGATGAGAAGAAATCTGCGGTGGCTGAAAATCGTGACCAACTTGGTGTTATCTAGATCTGCTTTATCTAGTTTGCAAGCCA
TAGGCTCAATTTTATGTCCTTCTTACTTACACACAGTAGCCCCACACAGTTTTGTTTTAAATGAAGGCAAAAGTAGACATTTTTAAAGTA
TATTCAACATTGTGCCATTATTTACCTGATAAAGGTGAAATCAGAGGTGTCCACGGCCTCAAAGTTTGGGCCCATGGGACTATCAAATCC
GAATTATATCTACTTAGAGCTTAGAGGAAGAATTAGGTATCATGAGAAAAGCAACTCCTACTTGAGAGAAAGAAGACTACCAAAGCATGT
TGAGGCTTTAACATGGGAGACTTCCAGGTAGGCGTTAACACTTGAGTGGTAACTAGCTTGATGAAGGAAAATAATTACTTTAGCAGTTAT
GTTGTAAAATTAATAAAAAGGACTCATGTTTATTCTGGTGTATTTGTCAACCCATGGGTAGTGATTACTCCGTGTACATTCTATAGTGTG
TGTATTTTATTTAGTGTCTTAATATATAGTCTTTATATAGTATCTTAATATTATTTACTGTTACTTCTAGTCATTTATGTAGTATATTTT
ACTGCAAAATTTGTAGCACTTTACTAATATTAGATCATTATTTTCCCTCTTCCCCTCTACCTTTCTGGCATTTTCTGTTATCTTAGAGTC
AGGAATCTAAAGGTCTAAGTCTAGAAATCTGTTGGAAGCTGGGTTGGAGCTACTGGATATGAGTTACTTTTTACATGTCTCCTTAAGAAG
ACTCTTTTATAATGTAATACTTAGAAGCCAAATCCTTTCAAACGCAAACACCCTTGAAACTTGATGCTTTCTGAAGTTGTATTCATAAAA
ATTATCCCATCTTACAGTTAATCAGAAGATGTTCTTACCTTTGGTTTGCCTGCCTCCTGAAACACAAACCTGCAGATTGCCCCTAACTTC
AGCAGTGCCTCCGTCACTGCATGTACCTAAAAGACAGGAAAGCCAAGTTCTGGGAGCTGTCAAGTCGGAGGATCAGGAAAATGGTGGGGA
AGAGGTGACTGGAAAGGCAGGCACTAAAGATGGCAGGCTGCAAAAGCATTCTGAGTTCCCCTGTAACAGATAGGTTTTATGAACTCAGCT
GTTTTCTTTTTTCTTTTTTTTTCTTTTGAGATGGAGTCTCACTCTGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTC
AGCTCACTGCAGCCTCCACCTCCCGGTTTCAAGTGATTCTCCCACCTCAGCCTCCCGAGTAGTTAGGATTACAGGTGCCCACCACCACGC
CCAACTAATTTTTGTATTTTTAGTAAAGACAGGGTGTCGCCATATTGGCTAGGCTGGTTTTGAACTCCTGACCTCAGGTAATCCACCCGC
CTCAGCCTCCCAAAGTGCTGGGATTATTATAGGCGTGAGCCACCATGCCCAGTGAACTTGGCCATTTTCTTACATTCATATATAGCAAAG
TTTTCAACTTGTCTACCGAGAGACTTTCTTTAGGAGCCAGGACTTCTACATTTGTAACTTGAGTATATTAATATTCAAATCATAGTTCAA
AAATACTGAAATACTTGTTTATTATGTTACATAAATATGGACACAATTACTGCCAAAGAATAGAGAGATTTGCTTATGAGAACATTCTGT
CATTTGTTCTGTTTGTAGATGAGAGACATGCTTTTAAAGTACAAAACGTTTCTCTTCTACCTTACCCCCTGTTCTACTGACGTGCTTTGC
ATGAGAAGCTCATCTAGAAGAGAGCAACGCTGGAATAGAGAAGTCTAGACCCTGGCCTTTGAGGGAAAGGACTGCTTTTTTTCTCTCCCA
AATTAGAAAATTAAAAGTGAAACATAACACATAAGGACGAAATACAATGTTCTGAATATCTTCCACTAATTAATTGTTGAATGATTAAGT
CTCTAAGTATCTTAACTTCCATTGTCTTCTTGTTAACCTAGACAAGAGTAGATTATTCAGTAGCCACATGTGACAGTTAAAATTAAGTAA
AATTAAAACTATAGTTTCTCAGTGGCCTAGCCACATTTCAAGTGTTCCACAGTCACATGTGGATAGTAGTTACCTATCAGACAGTACAGG
TATAGAACATTTCCAGTATTGCCAAAAATGCTATTCAACAGCACTTTTATTGCCCAGAGAGAAAATAAGGACAAAATAAAGGCAGTGAAG
TAACTTAAGACAACTCTGAGATTTTACCACCATACTTAGAGAAAGTTTTTCTGTTATAAAAATTAATACTAATCCTTTTTAAAGACCTTG
GAAAAAATCAAAACCCCATTCCTTTAAGCTAGTCTTCAGTATATATTTTTCTAAGAACAGATTCTCAATACTTTATTTTTCAAGTGATAA
AATCATTTTATAAATCATTTCTTAATATCTTCAGTGTTTTTTCCCTTTTTATGTAAACTCTTTTAAAATTGATATTAGCTGGGCATGGTA
GCTCATGCCTGTAGTCCCAGCTACTCCAGAGGTCGAGGCAGGAGCATCGCTTAAGCCCAGGAGGTTCAGGCTGCAGTAAGGTCTGATCAC
ACCTGACTGCACTCCAGCCTGGGTGGCAAAGCAAGACCCCTGTCTCTAAAAAAAAATAATATAAATTGATGTTATATAGTTAACATTTAT
CAGGCAAATTCATATGAATGCTTATTTCAAATAAAGATTGATAGATTTAATGATATCCTTCCTTTTAAATTTATATAGATCTAATGAACA
TTGCCAACAGTTTTTTTTGTTTCTGTCCCTTAAACATTTCCCCTGAAAGTCCACCTCAAAGGTACATCAAGATGCAAACAATTTTTTTAT
CTTCATAACTTCCTGCTCTTATTAACTTGTATTATGAATCAAATTAAGTTTTATGTATAAGGCATTTACTATTCCAGTGACTTAGCTAAT
GAAAACATTTAAAAATATGTATTAATTTACTTGGCCTGCTACTAAAGTGCTTAACATAACTAAATGGATCTATAGTAACATGTCTAAATT
TTTTAATGGAAATAAGGGACTAACCATAATCCTTTTGAGTCAGCTTGGTGCTTACAATTATTTTGTTAGGAAATCTTGATGCTTTCTTCT
TTCTCTTTAAATTTTTGTAATCAAGCAACAGACTTGATCCAGCAGTGTCGAATTCCAAGCAAGTTATGATGATTCTTATTGTAGTTCAAG
TACAGATGAGTAAGTGGTGTGACTTCAGTTTATTATCTTCTTGGTGACCTACTTTAGTATGTGTTCTGTAGCGATTCATATTAGTTAAGG
GACGTTTTCAATATGCTTGAAATAAGAAATAGCATTTTACTCTAAATACAAGAAATGACTGTACACAAATGCTAATCAGTGATTTGGGGC
CTTTTAATGTCTTTAACAGCAATCTTTTATTTATTTATTTATTTATTTTTGAGACGGAGTCTTGCTGTGTCACCAGGCTGGAGCAGTGGC
ACGATCTCGCCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCTATTCTCCTGCCTCAGCCTCCCAAGTAACTGGGACTGCAGGCACATGC
CACCACATCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTGGCCAGGATGATCTCGATCTCTTGATCTCGTGATCT
GCCCGCATTGGCCTCCTGAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCAAATCTTTTATTTTTTAACAGCCTTAGTTATT
TATAATTCAAATGCACTAAAATATCATCGCTGTCATGAACTTTGCTGTTTACAGGTTCTGTGTAATTCAGAATGCTTTGTACTTAGAAAA
TAATTTCTAGGCTTATCTTGTTTTGCAGTTTTCATGTTTTGACAATTGCCCACCATTTACAATACTCAATTTTTGATTATGAAATGAATA
GTAAAATTCAAACATATCTAATAATAATTTGCCTTAGTTTGATTAATAAATTATATCAAAAAACTTGGGGATAGAAAGAGGCTTTTTTTT
CCCCCTGTAGTATTTTTAAAACTTTTTAGATGAGCTGGATGAAACCTTAGTACATTGGAGCTGGAGTTGTATTGAGTACAGCCCCAACTC
TGAAGCCTTATATTCATGTCTTAAGTACCATTGATTGTTCTGTGAATTGTTGTTAGTTTCATATTTGACATTGTAGTAATCCACCTTGCA
TTTTAGTCTTTGCAAAAAGGATATTGCTAGGTATATTCTTATTTCTGATTGAGTATTGAATTTACATTTTTCAGAATTTCATTCTTTGTC
ATTATAATCCAAAAACAATGTCCACATCAGACTTGGAACTTCTCACTTCAAAAATGAAATACAGATTTAGCAGTGTTGTACATAATGATG
TCCAAGCATTTTTCCACCTGTTTACTGAGTTTTCCAACCATTTACTATGTGTTGAGATTGGTGGGTTTTCTGGCTGTTTTTCTGAGGTGA
ATGACTTGTTACAGAGCCTCAGTAAGAAATTTCAACTAAAATCACAAAAACATAAAGTCCAGGAAACCACCAGAAGATGGATTTTTAGTG
TTTTTGAAATCTTGTATTTCCTTTTGATATCATTTACTCATTTTAATTTTACGACTGCCAACTTGTTACGGTATTAATTATATGTATGTG
TTTATATGTATGCATATAATATATGTATATGTATATGAAGAATAAAGTTAAGATTTGGTCAAACTATATTTTCCCATTCAAGTACAAAAA

>95482_95482_1_TUSC3-HOOK3_TUSC3_chr8_15398077_ENST00000382020_HOOK3_chr8_42819454_ENST00000307602_length(amino acids)=575AA_BP=52
MGAHGYRAWRRHCPAAMGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKEVAALQEEKSSLLAENQVLMERLNQSDSI
EDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESY
KKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRL
RTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRK
NELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKK
EEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAED

--------------------------------------------------------------
>95482_95482_2_TUSC3-HOOK3_TUSC3_chr8_15398077_ENST00000503731_HOOK3_chr8_42819454_ENST00000307602_length(transcript)=13869nt_BP=286nt
CGGCCGCGGCCCGGGTCCCTCGCAAAGCCGCTGCCATCCCGGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGTGC
GCGGTAGGAGCTGGGCGCGCACGGCTACCGCGCGTGGAGGAGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGTAG
GCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGAGG
ACAGAAGAAAAAGGAGGTTGCAGCATTGCAGGAAGAGAAAAGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTCAATCAATC
TGATTCTATAGAAGACCCTAACAGTCCAGCAGGAAGAAGGCATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAAACATTCAG
ACTAGAAGCAGCCAAAGATGATTATCGAATACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGATGAACTGAC
CACTTTGGCAGATGAAGCTCAGTCTCTGAAAGATGAGATCGACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAAGGTCAAGT
AGAATCTTATAAAAAGAAGCTAGAAGACCTTGGTGATTTAAGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTATATGCAGAA
TACTGTCAGTCTAGAGGAAGAGTTAAGAAAGGCCAACGCAGCGCGAAGTCAACTTGAAACCTACAAGAGACAGGTAGTAGAACTACAAAA
CAGATTATCCGAAGAATCAAAGAAAGCAGATAAACTAGATTTTGAATATAAGCGGCTAAAAGAAAAAGTTGACAGTCTTCAAAAAGAAAA
GGACAGGCTGAGAACAGAAAGGGATTCTCTGAAGGAAACCATTGAAGAGCTTCGTTGTGTACAAGCTCAAGAAGGGCAGCTCACAACACA
AGGGTTAATGCCTCTTGGAAGTCAGGAGTCTTCAGACAGTCTAGCTGCAGAGATTGTTACACCTGAAATCAGGGAGAAACTTATTCGTCT
TCAGCATGAGAATAAGATGTTAAAGCTTAACCAAGAAGGTTCGGACAATGAAAAAATAGCCTTATTGCAGAGCCTTCTAGATGATGCAAA
TCTACGCAAGAATGAACTGGAGACAGAGAATAGGCTGGTGAATCAAAGACTTCTGGAAGTACAGTCACAAGTTGAAGAATTACAAAAATC
TTTACAGGATCAAGGCTCAAAAGCAGAAGATTCAGTCCTTCTAAAAAAGAAGCTTGAAGAACATCTAGAGAAGCTGCATGAGGCCAATAA
TGAACTACAGAAGAAGAGAGCCATTATTGAAGATCTCGAGCCAAGATTTAACAACAGCTCCTTAAAAATTGAAGAATTACAAGAAGCTTT
ACGAAAGAAAGAGGAAGAAATGAAGCAAATGGAAGAACGATACAAAAAATACTTAGAGAAAGCCAAAAGTGTCATCCGTACTTTAGATCC
TAAACAGAATCAAGGAGCAGCACCAGAAATACAAGCTCTTAAAAATCAGCTCCAGGAACGAGACCGACTGTTCCACTCATTAGAGAAAGA
ATATGAGAAAACAAAGAGTCAGAGAGAGATGGAAGAGAAATATATTGTTAGTGCCTGGTACAATATGGGAATGACCCTGCATAAAAAGGC
AGCTGAAGATAGACTGGCAAGCACAGGCTCAGGGCAGTCATTTCTGGCGAGGCAGAGGCAAGCGACCAGCAGCAGAAGATCATACCCAGG
CCACGTGCAGCCGGCCACAGCAAGGTAGAGAAGTTGTGCCGCTCAATCACAGACACCTGCACCCACAACATACTTCTGTTACACACAAGA
ACATTTCAGGAAACTCAGCCAGCTTATTTTTTGTTTCTCTTCTATGTCAATACTTAGTGTTTCTCATTTTGAGGACTTTTTCTCTCTCCT
GTATCTTTGTTTTAGTTTCTTTGGTTTTTATTTTGTAGTCCTTTCAGTTATTTTTAATGTGCCAAAAATTTGTACATGTTCAATTAAAAA
TGTTGTATAATAGTGTAATACTTTTCTTTGTATGAAAATGTCCTCTTCTTCAAAGGTATAGGCTTTGTAATGAATTAGATTTTCTGCCAA
TAATTGATATACAATTTATATTCTTTATTGTGCCTGTGTGTTACCATGCTAAGAATGTCTTTGTTTAAAGGGAATTAATCTTTTTATGAT
GTATTAATCTGTGTTTTCAATTGTTTTCCAAGTACAGTTCAAATAACTTGCATATTTACTATACAAAATGGTTGACAAGTGTTCTTTTTG
CAAAGACTTGAATACATTGGCAGAGGTGCTAATCACATCTTCCCTAAGGCACCTGGAAGAATTATTTGAGGAAAAAATGAGTTTTCACAT
TGTTTTATAGGAAATTAAATTTGTCCAAAGATTTGGAGACTATTTTTAAAACATAAATACATAAAATTTCATTATTTCCTGCTATCTTGT
TTGCTGGCAGAAGTGAATGTTTGGTGAGGTTATTTTGGGATAAATTACAAAAGAAAAAAAATTAGACACTGCATTAATTTCTTGTTCTTT
TGGAATATCTTAGTAACTGAGGATCATTTTCTAACAATGTGGTTGACATACCTTCAGTTGCTTTCCACATCTAAAAGAGTTATCTTTCAT
ATATGTACAAGTTATTGGTAGTCTTATTTTTGGGCTGTTTGTTGACTTATGCCCCATTTGTTTTACTTGTTCTTTAATATAAACCCTTCC
ATTTTTTAACAATTCCTAACACTTGATATCTTAATATCAGTCACTAACATTAGTAACTTCTTGTATGTTATATTATGGCAGATCTCTTTA
CGTTTTTTCTCACATCTATCTGCTAGTCCAGGAATTTGTTACTAAATAGATTTTCTTGGATATTTGGTTGCCTCAAAGTGCTTACATTTG
TTAACAGATTGTAAACCACATTTATTTACATTGATGAATGGGCTGTTGAATAATCATTGTAAAGCACTTTGTATATATAAGGTGCTATAT
AAGTGTGAAATATCATTCATTTATAAATGAAATGCCTTCTAACTTTCCATATTGACTTATGTATTTGGTCCCAAATTATATTTAAGTCTT
TTTTCTTGCAACGTAGCCCATTTTTTGAAAGCAAAACATTTCTGAAATTAGGTCATGGTTTTTTTGTTTATTTTTAGGTTAGGTCACTTA
ATATAGGAGGATGTTTTCTCATGTACTTGCTATTTGCAAGTTCAGGTTTCATTTGGTTCTTTATGTTAAATACGAATAAGTAACCTCAAA
TCAAGCTAAATGTAATTAAGAATTTTCAGCAACTATATTCAAGTGTTTGATTTTTAAATTCTTTCTTTCTTTTTAATAAGAAAGATGACC
TAAAAATCAGTGGTATTTGTTTGTCCTCAGAAGCCGTAGTTGAAGAAAGATATTAGAGTATACACAGAACTGGAGCCATACATTGTGCTA
ATTTTTTACATTAAGTACAGAAGTCTGAGCACAGCATGAATGCTTCTGCCTGACAGGACCACAAAGCAGCAGAAGTTAGGGATAAATGGA
GATAGCCATGAGTAGAACTGCTGTAGGGCTTCAGGAGGCTACGCAGACCTGATCAACTGCAAAGTTTCCAAAGTAAAAGATTAAAAACTT
TCAGACGGTTCTTACCTCTACCCGTGTTTCACAAATAGCCTGAGGATCCAACTATTTTTAAAGCAAATTGGGGCCAGACGTGGTGCCTCA
CGCCTGCAATCTCACCATTTGGGAGACCTAGGTGGGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAAC
CCCATCTCTACTAAATTACAAAAATTAGCTGGGCATGGTGGCATGTGGCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAGTCAC
TTGAACTCAGGAGCCAGAGACTGCAGTGAGCTGAGATCGCACCACTGCATTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAATCAGT
CAATCAATCAATCAATCAAATTGGAATATGAGCACTAACCTTGGTAAGTTAAAATTTTGGGAAAATTGTACCTGCAGAATATGATGGATG
AAAACAACAGCCAGGTGCAGTGGCTCACGCGTATAATCCCAGCACTTTGGGAGGCCGAGACAGGCACATCATCTGAGGTCAGGACTTCCA
GACCAGCCTGTCCAACATGGTGAAACTCCGTCTCTACTAAAAATACAAACAATTAGCCAGGCATGGTGGTGTGTGCCTGTAGTCCCAGCT
ACTTGGGAGGGTGAGGCAGGAGAATTGCTTGAACCTGGGAGACAGAGATTGCAGTGAGCCGAGATGGCGCCATTGCACCCCAGCCTGGCG
ACAAGAGCGAAACTCTGTCGCAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAACAGTCTGTGAACTACTCACTGAATGAATTTTGTTCTG
TGAGATGAGAGGTTTTCATTTTCATTTTCTATTTACAGCCCCAGTCCTAATCTCCTACCCATCCACCTACCCAGATATTTTTTCTCTATC
TGGGTTGGAAAGGCCCCAGGCTTTTAGAGGGGAGTTTTACTTCTGACTTTTTTTTCCCCCCGAGACGGAGCCTCGTTCCGTCACCCAGGC
TGTAGTGCCGTGGCATGATCTCGGCTCACTGCAGCCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGA
TTACAGGTGCCCACCACCATGGCTGGCTAATTTTTGTAATTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCT
GACCTCGTGATCTACCCACCTCGGCCTCCCAAAGTGCTGAGATTACAGGCACGAGCCACCGCGCCCAGTCGTACTTCTGACTTTTCTTCA
GCATCTGTTGTATGCTATTATTTTGATGTTTACATTTATAATTTTCTTTCTTTTTTTTTTTTTTGTGAGATGATGTCTCGCTCTGTCACC
CAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGC
GGGGACTACAGGCGCCCGCCACTACGCCCGACTAATTTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTC
GATCTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAGAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTACATTTATAAT
TTTCATTCTCTTTTACCTATAAAATTCAGTGTATTAGTTTCATTACATAGGAGAAATTATATTTCTAAACATTTTATGATGTTTAAAAAC
AAAACAGGCTGTTGTAAAAAAAAAAAAAAAAAAAACTTCTGAATATACTTTAGGTATCAGAAAGCCAAGAATAAAATTTAGCTCTAACGG
TGGCAACTCCATGTCCGGTGTCCAGCTTTGGACAGGGTTTATGACGTTTCTGTTTCTCTAGTAATGATTAATGATTCCTCAGGAGATTCG
TGATGTTGTCTGGTCTATCTGGAAATTTAAAGTCACTAGGAGCTTTGCCTCATCGTGAGTGATGCTGTGCTGTATTTTTACAAACTCTCG
CATACAGCACCTTCCTGGGGCCACGTTGGCTTGTGCAGTGGAGCTTGTCCAGGCACCAGCATGGAGCAAGTACAGGGTTGCTGTGTTGGG
TTGGAGCACACTGTCACCACAGTGTCTGAAGTCTTATAAACAGGAAGATCATTTTCTGTTTTCCTTCTAACCAGGGTGAGAAAATACAAA
GTAAAGAACTAAAGAATATTAAAACCTAGCATTTATGTTCCACAGTGTGTATTTCAGAAGTTTGTAATCCAGAAAATATAGTAGTGTATA
ATATCTGAAAAGAGAATCAAGTATACAATTGTACATATTTTTAAAGAACTTTGAAAAACTCCGTCATATCTTTTACCATTTGTCTATTTG
ATAGTAATGCAGAAAAAAGTCCCTAAAGACCCTGTGTTCCAAAATTTACCAAGATTGACATTTCTATTAGACATCCTTAACCTAAGTGTT
TTAATTAGATTATTAGACTATAATAAGGATGAAATTGCTGTCTGTAATTTTGTTGAGGTTTTATTGTTAATATAATAAAAGCTCAACTGT
ACAAAATTAAGCTAAATGTTATCCAGTCAGAAACATCAGCCTGTGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGG
CCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCTAATATGGTGAAACCCCATCTCTACTAAAAATACAGTATTAG
CCAGGCATGGTGGCAGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCATGTGAACCCAGGAGGTGGAGGTTGCAGTA
AGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCCACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAGAAACATCAGCC
TGTATATTCCAGTAGTTCTCACAGAAGAATGAAAATCCGTGCTGTGCAAATAGATCAGTAGTGAGTGAGTGTTAAGTGAAAGATGAGCTA
GGTTGAAGAAAATATACATTTTATTGATGAGCCACTTTGCTATCTCTCCTTCCTTCCTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTT
CCCTTCTTTTCTTTTTTCTTTTCTTTTCTTTTCTCCCTCCTTTCTTCCTTCCCTTCCCTTCCCCTCCCCTCCCCCAGGCTGGAGTGCAGA
GGCACGATCCTGGCTGACTGCAAACTCTGCCTACCAGGTTCAAGCGATTCTCCTGCCTCATCCTCCCTAGTAGCTAGGATTACAGGCATC
TGCCACCACGCCCAGCTAATTTTTGTATTTTTACAAAATACAAAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAACTCCTGA
CCTCAGGTGATCCGTCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGTGTTACTGCCCCAGCCTCCTATTTCCTTTTCGAAAGT
AGCAGTTTGGTTTATTCTCGTTTGCTAAGTAATTGTTTGAAATATTTTTCAGCCTCTCCTGCTCCCTCACAAAAATTCACCTGTCATTTT
AATGATAACAGCATGTTAAAAACTTGGAAGTCTTTATCCCAATATAAGAATTATCTTGAAACAAAAATCTAAATTACTTTTAAAAATTCT
CTTAACTCTGCATTTAGTCTCCTATTATCTAGATCTCTGAGTCCAGGATAACTCCAGTTATCCCCAGTTGGATCATGTGTGATTTATCTG
AGAAAGCATCCACAACCCACAGCTAGTGGAAACCGAGCTAGTTTACAGCCACGTGGATAAGAACATCTTTGTTTCTAAAGTGAGAGGAAA
GTGCTTGGTATCTTGCTTTTTGCTGAGGGCAAAATAACAACATGAAGACAAAGTGCTTTTTGTTGTCTATTCATGAAACTGTAGAAGAAT
ATTTTGAGTTTTTATTCTTATATTATGAAGGGATTCTTTGCCTAGCAGTGGCCGTCAAACTGATGTAGCATTGTACTTCTCAACAGTGAA
GCCTGTGTAATACCATACAGTAGGATGAAAGACTATTCTGAGCAAAATCAAATGGGATGTCAGAATCTTTGAAAATTATTTTATCATTTT
TTCTATTTTTTCATTTTTATAAATTAGAAGGATTTTCCATTCAATAAGGATAATCTCTCTTCCTATCATTCTGTCAAAATGGCAGTTTCT
TTTGGTAATTATCCAACCTAGTTTCATTACATTTAGAAGGAGGTTTCAGAGCTTATTCTTGATAACTATAATAATGATTTGAATGTTTTA
TATCATGAAGTTTTTTCTATGAGGAAGGCTATTCTCAATGTATCTGTCGTCTAATTTTTTATTTTCTATCTATAAAGAATATTTAAATAA
TAATTGGTGTATGTTCCTTTTGTTGAAAATGTTTTATTGTCCAGTTTTAACACAGAAGTGGTCTAAAGTTTTGCAGCAAATGCTGTTCAG
TTCCCAGAAGCCTAAAAAACATAACATAATATGCTAACAGAGCTAATTTCCACCCAATCCCTCAAATTACCGAAGTATTAATATTTAGCT
TCCTTTCTAGAAAACAAGGGGCAGCACAAATGGGGTGGCATCCATCTCTTTTAAATCACTGATGATTTTCTGGGGAAGTATATATAGATG
ATTTTATTTTTTAAATAGCCTTTTATCAAACCATTTCACATGTATTATCTATATGACTATAGAAACTTATAAAACATTTAATTCATGTTG
ACTTAAAACATGGGCATCCTTGGATTCTCCACATTGACTGAAATGATAGAGAAAGGGACATTTGTTTGAGAAACAAGAGACCTGTACCTA
ATTATGGCAAGTATATGAGTTTTGGTGATTGTGGGGGGTTATAAATGTTTTCCTATGATAGATAAATATATAGATATAGATCAGGAATTA
CTTGATGTCTCTTCAGAAGTTTTCTGTTTTCTTATAATTTCCAGTAATACTCTGTAAGACTCGGTTTGCATGCTGTGTGTGTTTGCATGA
GTATAGAAACCTAAGAACATAATGGAAGGCTATTAAGGCAAATTCATTCCTAGAAAGTGGAGTGGATCATTGGGATAAGAAATAGCCTAA
TTATAAACAAATATGCAGGCAGAGGGAAGTCCTAATACAATGAAAACTTGCATTATCTAAACAGATGTTCCCAAAGCAATAGTTTGCCTA
AAATCCTCTGTATTACATGATTATTCAGTAAAAGAGTAAACAAATATCTAATTTATTTTCTAATTGTCCTTCCCTTCATTGAGTATTAAC
TAGGTGCATAATGTAGTTGTATATGTTTACTAGTAAAGGGAAAAACACTTATTTTCATTTTGAGACTGTTTGGCTATTACTAAAGCTGAG
AAAGTGATTTTAGGTCGCCAAGGATACTATGATTTGATGAGATGAGAAGAAATCTGCGGTGGCTGAAAATCGTGACCAACTTGGTGTTAT
CTAGATCTGCTTTATCTAGTTTGCAAGCCATAGGCTCAATTTTATGTCCTTCTTACTTACACACAGTAGCCCCACACAGTTTTGTTTTAA
ATGAAGGCAAAAGTAGACATTTTTAAAGTATATTCAACATTGTGCCATTATTTACCTGATAAAGGTGAAATCAGAGGTGTCCACGGCCTC
AAAGTTTGGGCCCATGGGACTATCAAATCCGAATTATATCTACTTAGAGCTTAGAGGAAGAATTAGGTATCATGAGAAAAGCAACTCCTA
CTTGAGAGAAAGAAGACTACCAAAGCATGTTGAGGCTTTAACATGGGAGACTTCCAGGTAGGCGTTAACACTTGAGTGGTAACTAGCTTG
ATGAAGGAAAATAATTACTTTAGCAGTTATGTTGTAAAATTAATAAAAAGGACTCATGTTTATTCTGGTGTATTTGTCAACCCATGGGTA
GTGATTACTCCGTGTACATTCTATAGTGTGTGTATTTTATTTAGTGTCTTAATATATAGTCTTTATATAGTATCTTAATATTATTTACTG
TTACTTCTAGTCATTTATGTAGTATATTTTACTGCAAAATTTGTAGCACTTTACTAATATTAGATCATTATTTTCCCTCTTCCCCTCTAC
CTTTCTGGCATTTTCTGTTATCTTAGAGTCAGGAATCTAAAGGTCTAAGTCTAGAAATCTGTTGGAAGCTGGGTTGGAGCTACTGGATAT
GAGTTACTTTTTACATGTCTCCTTAAGAAGACTCTTTTATAATGTAATACTTAGAAGCCAAATCCTTTCAAACGCAAACACCCTTGAAAC
TTGATGCTTTCTGAAGTTGTATTCATAAAAATTATCCCATCTTACAGTTAATCAGAAGATGTTCTTACCTTTGGTTTGCCTGCCTCCTGA
AACACAAACCTGCAGATTGCCCCTAACTTCAGCAGTGCCTCCGTCACTGCATGTACCTAAAAGACAGGAAAGCCAAGTTCTGGGAGCTGT
CAAGTCGGAGGATCAGGAAAATGGTGGGGAAGAGGTGACTGGAAAGGCAGGCACTAAAGATGGCAGGCTGCAAAAGCATTCTGAGTTCCC
CTGTAACAGATAGGTTTTATGAACTCAGCTGTTTTCTTTTTTCTTTTTTTTTCTTTTGAGATGGAGTCTCACTCTGAGTCTCACTCTGTT
GCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAGCCTCCACCTCCCGGTTTCAAGTGATTCTCCCACCTCAGCCTCCCGAGT
AGTTAGGATTACAGGTGCCCACCACCACGCCCAACTAATTTTTGTATTTTTAGTAAAGACAGGGTGTCGCCATATTGGCTAGGCTGGTTT
TGAACTCCTGACCTCAGGTAATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTATTATAGGCGTGAGCCACCATGCCCAGTGAACTTG
GCCATTTTCTTACATTCATATATAGCAAAGTTTTCAACTTGTCTACCGAGAGACTTTCTTTAGGAGCCAGGACTTCTACATTTGTAACTT
GAGTATATTAATATTCAAATCATAGTTCAAAAATACTGAAATACTTGTTTATTATGTTACATAAATATGGACACAATTACTGCCAAAGAA
TAGAGAGATTTGCTTATGAGAACATTCTGTCATTTGTTCTGTTTGTAGATGAGAGACATGCTTTTAAAGTACAAAACGTTTCTCTTCTAC
CTTACCCCCTGTTCTACTGACGTGCTTTGCATGAGAAGCTCATCTAGAAGAGAGCAACGCTGGAATAGAGAAGTCTAGACCCTGGCCTTT
GAGGGAAAGGACTGCTTTTTTTCTCTCCCAAATTAGAAAATTAAAAGTGAAACATAACACATAAGGACGAAATACAATGTTCTGAATATC
TTCCACTAATTAATTGTTGAATGATTAAGTCTCTAAGTATCTTAACTTCCATTGTCTTCTTGTTAACCTAGACAAGAGTAGATTATTCAG
TAGCCACATGTGACAGTTAAAATTAAGTAAAATTAAAACTATAGTTTCTCAGTGGCCTAGCCACATTTCAAGTGTTCCACAGTCACATGT
GGATAGTAGTTACCTATCAGACAGTACAGGTATAGAACATTTCCAGTATTGCCAAAAATGCTATTCAACAGCACTTTTATTGCCCAGAGA
GAAAATAAGGACAAAATAAAGGCAGTGAAGTAACTTAAGACAACTCTGAGATTTTACCACCATACTTAGAGAAAGTTTTTCTGTTATAAA
AATTAATACTAATCCTTTTTAAAGACCTTGGAAAAAATCAAAACCCCATTCCTTTAAGCTAGTCTTCAGTATATATTTTTCTAAGAACAG
ATTCTCAATACTTTATTTTTCAAGTGATAAAATCATTTTATAAATCATTTCTTAATATCTTCAGTGTTTTTTCCCTTTTTATGTAAACTC
TTTTAAAATTGATATTAGCTGGGCATGGTAGCTCATGCCTGTAGTCCCAGCTACTCCAGAGGTCGAGGCAGGAGCATCGCTTAAGCCCAG
GAGGTTCAGGCTGCAGTAAGGTCTGATCACACCTGACTGCACTCCAGCCTGGGTGGCAAAGCAAGACCCCTGTCTCTAAAAAAAAATAAT
ATAAATTGATGTTATATAGTTAACATTTATCAGGCAAATTCATATGAATGCTTATTTCAAATAAAGATTGATAGATTTAATGATATCCTT
CCTTTTAAATTTATATAGATCTAATGAACATTGCCAACAGTTTTTTTTGTTTCTGTCCCTTAAACATTTCCCCTGAAAGTCCACCTCAAA
GGTACATCAAGATGCAAACAATTTTTTTATCTTCATAACTTCCTGCTCTTATTAACTTGTATTATGAATCAAATTAAGTTTTATGTATAA
GGCATTTACTATTCCAGTGACTTAGCTAATGAAAACATTTAAAAATATGTATTAATTTACTTGGCCTGCTACTAAAGTGCTTAACATAAC
TAAATGGATCTATAGTAACATGTCTAAATTTTTTAATGGAAATAAGGGACTAACCATAATCCTTTTGAGTCAGCTTGGTGCTTACAATTA
TTTTGTTAGGAAATCTTGATGCTTTCTTCTTTCTCTTTAAATTTTTGTAATCAAGCAACAGACTTGATCCAGCAGTGTCGAATTCCAAGC
AAGTTATGATGATTCTTATTGTAGTTCAAGTACAGATGAGTAAGTGGTGTGACTTCAGTTTATTATCTTCTTGGTGACCTACTTTAGTAT
GTGTTCTGTAGCGATTCATATTAGTTAAGGGACGTTTTCAATATGCTTGAAATAAGAAATAGCATTTTACTCTAAATACAAGAAATGACT
GTACACAAATGCTAATCAGTGATTTGGGGCCTTTTAATGTCTTTAACAGCAATCTTTTATTTATTTATTTATTTATTTTTGAGACGGAGT
CTTGCTGTGTCACCAGGCTGGAGCAGTGGCACGATCTCGCCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCTATTCTCCTGCCTCAGCC
TCCCAAGTAACTGGGACTGCAGGCACATGCCACCACATCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTGGCCAG
GATGATCTCGATCTCTTGATCTCGTGATCTGCCCGCATTGGCCTCCTGAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCAA
ATCTTTTATTTTTTAACAGCCTTAGTTATTTATAATTCAAATGCACTAAAATATCATCGCTGTCATGAACTTTGCTGTTTACAGGTTCTG
TGTAATTCAGAATGCTTTGTACTTAGAAAATAATTTCTAGGCTTATCTTGTTTTGCAGTTTTCATGTTTTGACAATTGCCCACCATTTAC
AATACTCAATTTTTGATTATGAAATGAATAGTAAAATTCAAACATATCTAATAATAATTTGCCTTAGTTTGATTAATAAATTATATCAAA
AAACTTGGGGATAGAAAGAGGCTTTTTTTTCCCCCTGTAGTATTTTTAAAACTTTTTAGATGAGCTGGATGAAACCTTAGTACATTGGAG
CTGGAGTTGTATTGAGTACAGCCCCAACTCTGAAGCCTTATATTCATGTCTTAAGTACCATTGATTGTTCTGTGAATTGTTGTTAGTTTC
ATATTTGACATTGTAGTAATCCACCTTGCATTTTAGTCTTTGCAAAAAGGATATTGCTAGGTATATTCTTATTTCTGATTGAGTATTGAA
TTTACATTTTTCAGAATTTCATTCTTTGTCATTATAATCCAAAAACAATGTCCACATCAGACTTGGAACTTCTCACTTCAAAAATGAAAT
ACAGATTTAGCAGTGTTGTACATAATGATGTCCAAGCATTTTTCCACCTGTTTACTGAGTTTTCCAACCATTTACTATGTGTTGAGATTG
GTGGGTTTTCTGGCTGTTTTTCTGAGGTGAATGACTTGTTACAGAGCCTCAGTAAGAAATTTCAACTAAAATCACAAAAACATAAAGTCC
AGGAAACCACCAGAAGATGGATTTTTAGTGTTTTTGAAATCTTGTATTTCCTTTTGATATCATTTACTCATTTTAATTTTACGACTGCCA
ACTTGTTACGGTATTAATTATATGTATGTGTTTATATGTATGCATATAATATATGTATATGTATATGAAGAATAAAGTTAAGATTTGGTC
AAACTATATTTTCCCATTCAAGTACAAAAATGTTTTCAAGGCTGCAAAAAGTGTACAGTTGTTAAACAAGTTGTAAATAAAGACTTGTAT

>95482_95482_2_TUSC3-HOOK3_TUSC3_chr8_15398077_ENST00000503731_HOOK3_chr8_42819454_ENST00000307602_length(amino acids)=575AA_BP=52
MGAHGYRAWRRHCPAAMGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKEVAALQEEKSSLLAENQVLMERLNQSDSI
EDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESY
KKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRL
RTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRK
NELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKK
EEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAED

--------------------------------------------------------------
>95482_95482_3_TUSC3-HOOK3_TUSC3_chr8_15398077_ENST00000506802_HOOK3_chr8_42819454_ENST00000307602_length(transcript)=13919nt_BP=336nt
GTCTTCTCCCGGTGAACCGGATGCTCTGTCAGTCTCCTCCTCTGCGTCCTCGGCCGCGGCCCGGGTCCCTCGCAAAGCCGCTGCCATCCC
GGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGTGCGCGGTAGGAGCTGGGCGCGCACGGCTACCGCGCGTGGAGG
AGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGTAGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGC
TTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGAGGACAGAAGAAAAAGGAGGTTGCAGCATTGCAGGAAGAGAAA
AGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTCAATCAATCTGATTCTATAGAAGACCCTAACAGTCCAGCAGGAAGAAGG
CATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAAACATTCAGACTAGAAGCAGCCAAAGATGATTATCGAATACGTTGTGAA
GAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGATGAACTGACCACTTTGGCAGATGAAGCTCAGTCTCTGAAAGATGAGATC
GACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAAGGTCAAGTAGAATCTTATAAAAAGAAGCTAGAAGACCTTGGTGATTTA
AGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTATATGCAGAATACTGTCAGTCTAGAGGAAGAGTTAAGAAAGGCCAACGCA
GCGCGAAGTCAACTTGAAACCTACAAGAGACAGGTAGTAGAACTACAAAACAGATTATCCGAAGAATCAAAGAAAGCAGATAAACTAGAT
TTTGAATATAAGCGGCTAAAAGAAAAAGTTGACAGTCTTCAAAAAGAAAAGGACAGGCTGAGAACAGAAAGGGATTCTCTGAAGGAAACC
ATTGAAGAGCTTCGTTGTGTACAAGCTCAAGAAGGGCAGCTCACAACACAAGGGTTAATGCCTCTTGGAAGTCAGGAGTCTTCAGACAGT
CTAGCTGCAGAGATTGTTACACCTGAAATCAGGGAGAAACTTATTCGTCTTCAGCATGAGAATAAGATGTTAAAGCTTAACCAAGAAGGT
TCGGACAATGAAAAAATAGCCTTATTGCAGAGCCTTCTAGATGATGCAAATCTACGCAAGAATGAACTGGAGACAGAGAATAGGCTGGTG
AATCAAAGACTTCTGGAAGTACAGTCACAAGTTGAAGAATTACAAAAATCTTTACAGGATCAAGGCTCAAAAGCAGAAGATTCAGTCCTT
CTAAAAAAGAAGCTTGAAGAACATCTAGAGAAGCTGCATGAGGCCAATAATGAACTACAGAAGAAGAGAGCCATTATTGAAGATCTCGAG
CCAAGATTTAACAACAGCTCCTTAAAAATTGAAGAATTACAAGAAGCTTTACGAAAGAAAGAGGAAGAAATGAAGCAAATGGAAGAACGA
TACAAAAAATACTTAGAGAAAGCCAAAAGTGTCATCCGTACTTTAGATCCTAAACAGAATCAAGGAGCAGCACCAGAAATACAAGCTCTT
AAAAATCAGCTCCAGGAACGAGACCGACTGTTCCACTCATTAGAGAAAGAATATGAGAAAACAAAGAGTCAGAGAGAGATGGAAGAGAAA
TATATTGTTAGTGCCTGGTACAATATGGGAATGACCCTGCATAAAAAGGCAGCTGAAGATAGACTGGCAAGCACAGGCTCAGGGCAGTCA
TTTCTGGCGAGGCAGAGGCAAGCGACCAGCAGCAGAAGATCATACCCAGGCCACGTGCAGCCGGCCACAGCAAGGTAGAGAAGTTGTGCC
GCTCAATCACAGACACCTGCACCCACAACATACTTCTGTTACACACAAGAACATTTCAGGAAACTCAGCCAGCTTATTTTTTGTTTCTCT
TCTATGTCAATACTTAGTGTTTCTCATTTTGAGGACTTTTTCTCTCTCCTGTATCTTTGTTTTAGTTTCTTTGGTTTTTATTTTGTAGTC
CTTTCAGTTATTTTTAATGTGCCAAAAATTTGTACATGTTCAATTAAAAATGTTGTATAATAGTGTAATACTTTTCTTTGTATGAAAATG
TCCTCTTCTTCAAAGGTATAGGCTTTGTAATGAATTAGATTTTCTGCCAATAATTGATATACAATTTATATTCTTTATTGTGCCTGTGTG
TTACCATGCTAAGAATGTCTTTGTTTAAAGGGAATTAATCTTTTTATGATGTATTAATCTGTGTTTTCAATTGTTTTCCAAGTACAGTTC
AAATAACTTGCATATTTACTATACAAAATGGTTGACAAGTGTTCTTTTTGCAAAGACTTGAATACATTGGCAGAGGTGCTAATCACATCT
TCCCTAAGGCACCTGGAAGAATTATTTGAGGAAAAAATGAGTTTTCACATTGTTTTATAGGAAATTAAATTTGTCCAAAGATTTGGAGAC
TATTTTTAAAACATAAATACATAAAATTTCATTATTTCCTGCTATCTTGTTTGCTGGCAGAAGTGAATGTTTGGTGAGGTTATTTTGGGA
TAAATTACAAAAGAAAAAAAATTAGACACTGCATTAATTTCTTGTTCTTTTGGAATATCTTAGTAACTGAGGATCATTTTCTAACAATGT
GGTTGACATACCTTCAGTTGCTTTCCACATCTAAAAGAGTTATCTTTCATATATGTACAAGTTATTGGTAGTCTTATTTTTGGGCTGTTT
GTTGACTTATGCCCCATTTGTTTTACTTGTTCTTTAATATAAACCCTTCCATTTTTTAACAATTCCTAACACTTGATATCTTAATATCAG
TCACTAACATTAGTAACTTCTTGTATGTTATATTATGGCAGATCTCTTTACGTTTTTTCTCACATCTATCTGCTAGTCCAGGAATTTGTT
ACTAAATAGATTTTCTTGGATATTTGGTTGCCTCAAAGTGCTTACATTTGTTAACAGATTGTAAACCACATTTATTTACATTGATGAATG
GGCTGTTGAATAATCATTGTAAAGCACTTTGTATATATAAGGTGCTATATAAGTGTGAAATATCATTCATTTATAAATGAAATGCCTTCT
AACTTTCCATATTGACTTATGTATTTGGTCCCAAATTATATTTAAGTCTTTTTTCTTGCAACGTAGCCCATTTTTTGAAAGCAAAACATT
TCTGAAATTAGGTCATGGTTTTTTTGTTTATTTTTAGGTTAGGTCACTTAATATAGGAGGATGTTTTCTCATGTACTTGCTATTTGCAAG
TTCAGGTTTCATTTGGTTCTTTATGTTAAATACGAATAAGTAACCTCAAATCAAGCTAAATGTAATTAAGAATTTTCAGCAACTATATTC
AAGTGTTTGATTTTTAAATTCTTTCTTTCTTTTTAATAAGAAAGATGACCTAAAAATCAGTGGTATTTGTTTGTCCTCAGAAGCCGTAGT
TGAAGAAAGATATTAGAGTATACACAGAACTGGAGCCATACATTGTGCTAATTTTTTACATTAAGTACAGAAGTCTGAGCACAGCATGAA
TGCTTCTGCCTGACAGGACCACAAAGCAGCAGAAGTTAGGGATAAATGGAGATAGCCATGAGTAGAACTGCTGTAGGGCTTCAGGAGGCT
ACGCAGACCTGATCAACTGCAAAGTTTCCAAAGTAAAAGATTAAAAACTTTCAGACGGTTCTTACCTCTACCCGTGTTTCACAAATAGCC
TGAGGATCCAACTATTTTTAAAGCAAATTGGGGCCAGACGTGGTGCCTCACGCCTGCAATCTCACCATTTGGGAGACCTAGGTGGGGGTG
GATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAATTACAAAAATTAGCTGGGCATGGTG
GCATGTGGCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAGTCACTTGAACTCAGGAGCCAGAGACTGCAGTGAGCTGAGATCGC
ACCACTGCATTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAATCAGTCAATCAATCAATCAATCAAATTGGAATATGAGCACTAACC
TTGGTAAGTTAAAATTTTGGGAAAATTGTACCTGCAGAATATGATGGATGAAAACAACAGCCAGGTGCAGTGGCTCACGCGTATAATCCC
AGCACTTTGGGAGGCCGAGACAGGCACATCATCTGAGGTCAGGACTTCCAGACCAGCCTGTCCAACATGGTGAAACTCCGTCTCTACTAA
AAATACAAACAATTAGCCAGGCATGGTGGTGTGTGCCTGTAGTCCCAGCTACTTGGGAGGGTGAGGCAGGAGAATTGCTTGAACCTGGGA
GACAGAGATTGCAGTGAGCCGAGATGGCGCCATTGCACCCCAGCCTGGCGACAAGAGCGAAACTCTGTCGCAAGAAAAAAAAAAAAAAAA
AAAAAAAAAAAAACAGTCTGTGAACTACTCACTGAATGAATTTTGTTCTGTGAGATGAGAGGTTTTCATTTTCATTTTCTATTTACAGCC
CCAGTCCTAATCTCCTACCCATCCACCTACCCAGATATTTTTTCTCTATCTGGGTTGGAAAGGCCCCAGGCTTTTAGAGGGGAGTTTTAC
TTCTGACTTTTTTTTCCCCCCGAGACGGAGCCTCGTTCCGTCACCCAGGCTGTAGTGCCGTGGCATGATCTCGGCTCACTGCAGCCTCTG
CCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCAGAGTAGCTGGGATTACAGGTGCCCACCACCATGGCTGGCTAATTTTTGTAAT
TTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCGTGATCTACCCACCTCGGCCTCCCAAAGTGCTGA
GATTACAGGCACGAGCCACCGCGCCCAGTCGTACTTCTGACTTTTCTTCAGCATCTGTTGTATGCTATTATTTTGATGTTTACATTTATA
ATTTTCTTTCTTTTTTTTTTTTTTGTGAGATGATGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAG
CTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCGGGGACTACAGGCGCCCGCCACTACGCCCGACTAATTTTT
TGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAG
AGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTACATTTATAATTTTCATTCTCTTTTACCTATAAAATTCAGTGTATTAGTTT
CATTACATAGGAGAAATTATATTTCTAAACATTTTATGATGTTTAAAAACAAAACAGGCTGTTGTAAAAAAAAAAAAAAAAAAAACTTCT
GAATATACTTTAGGTATCAGAAAGCCAAGAATAAAATTTAGCTCTAACGGTGGCAACTCCATGTCCGGTGTCCAGCTTTGGACAGGGTTT
ATGACGTTTCTGTTTCTCTAGTAATGATTAATGATTCCTCAGGAGATTCGTGATGTTGTCTGGTCTATCTGGAAATTTAAAGTCACTAGG
AGCTTTGCCTCATCGTGAGTGATGCTGTGCTGTATTTTTACAAACTCTCGCATACAGCACCTTCCTGGGGCCACGTTGGCTTGTGCAGTG
GAGCTTGTCCAGGCACCAGCATGGAGCAAGTACAGGGTTGCTGTGTTGGGTTGGAGCACACTGTCACCACAGTGTCTGAAGTCTTATAAA
CAGGAAGATCATTTTCTGTTTTCCTTCTAACCAGGGTGAGAAAATACAAAGTAAAGAACTAAAGAATATTAAAACCTAGCATTTATGTTC
CACAGTGTGTATTTCAGAAGTTTGTAATCCAGAAAATATAGTAGTGTATAATATCTGAAAAGAGAATCAAGTATACAATTGTACATATTT
TTAAAGAACTTTGAAAAACTCCGTCATATCTTTTACCATTTGTCTATTTGATAGTAATGCAGAAAAAAGTCCCTAAAGACCCTGTGTTCC
AAAATTTACCAAGATTGACATTTCTATTAGACATCCTTAACCTAAGTGTTTTAATTAGATTATTAGACTATAATAAGGATGAAATTGCTG
TCTGTAATTTTGTTGAGGTTTTATTGTTAATATAATAAAAGCTCAACTGTACAAAATTAAGCTAAATGTTATCCAGTCAGAAACATCAGC
CTGTGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACC
AGCCTGGCTAATATGGTGAAACCCCATCTCTACTAAAAATACAGTATTAGCCAGGCATGGTGGCAGGCGCCTGTGATCCCAGCTACTTGG
GAGGCTGAGGCAGGAGAATCATGTGAACCCAGGAGGTGGAGGTTGCAGTAAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCCACAGA
GTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAGAAACATCAGCCTGTATATTCCAGTAGTTCTCACAGAAGAATGAAAATCCGT
GCTGTGCAAATAGATCAGTAGTGAGTGAGTGTTAAGTGAAAGATGAGCTAGGTTGAAGAAAATATACATTTTATTGATGAGCCACTTTGC
TATCTCTCCTTCCTTCCTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCCTTCTTTTCTTTTTTCTTTTCTTTTCTTTTCTCCCTCC
TTTCTTCCTTCCCTTCCCTTCCCCTCCCCTCCCCCAGGCTGGAGTGCAGAGGCACGATCCTGGCTGACTGCAAACTCTGCCTACCAGGTT
CAAGCGATTCTCCTGCCTCATCCTCCCTAGTAGCTAGGATTACAGGCATCTGCCACCACGCCCAGCTAATTTTTGTATTTTTACAAAATA
CAAAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAACTCCTGACCTCAGGTGATCCGTCCACCTTGGCCTCCCAAAGTGCTGG
GATTACAGGCGTGTGTTACTGCCCCAGCCTCCTATTTCCTTTTCGAAAGTAGCAGTTTGGTTTATTCTCGTTTGCTAAGTAATTGTTTGA
AATATTTTTCAGCCTCTCCTGCTCCCTCACAAAAATTCACCTGTCATTTTAATGATAACAGCATGTTAAAAACTTGGAAGTCTTTATCCC
AATATAAGAATTATCTTGAAACAAAAATCTAAATTACTTTTAAAAATTCTCTTAACTCTGCATTTAGTCTCCTATTATCTAGATCTCTGA
GTCCAGGATAACTCCAGTTATCCCCAGTTGGATCATGTGTGATTTATCTGAGAAAGCATCCACAACCCACAGCTAGTGGAAACCGAGCTA
GTTTACAGCCACGTGGATAAGAACATCTTTGTTTCTAAAGTGAGAGGAAAGTGCTTGGTATCTTGCTTTTTGCTGAGGGCAAAATAACAA
CATGAAGACAAAGTGCTTTTTGTTGTCTATTCATGAAACTGTAGAAGAATATTTTGAGTTTTTATTCTTATATTATGAAGGGATTCTTTG
CCTAGCAGTGGCCGTCAAACTGATGTAGCATTGTACTTCTCAACAGTGAAGCCTGTGTAATACCATACAGTAGGATGAAAGACTATTCTG
AGCAAAATCAAATGGGATGTCAGAATCTTTGAAAATTATTTTATCATTTTTTCTATTTTTTCATTTTTATAAATTAGAAGGATTTTCCAT
TCAATAAGGATAATCTCTCTTCCTATCATTCTGTCAAAATGGCAGTTTCTTTTGGTAATTATCCAACCTAGTTTCATTACATTTAGAAGG
AGGTTTCAGAGCTTATTCTTGATAACTATAATAATGATTTGAATGTTTTATATCATGAAGTTTTTTCTATGAGGAAGGCTATTCTCAATG
TATCTGTCGTCTAATTTTTTATTTTCTATCTATAAAGAATATTTAAATAATAATTGGTGTATGTTCCTTTTGTTGAAAATGTTTTATTGT
CCAGTTTTAACACAGAAGTGGTCTAAAGTTTTGCAGCAAATGCTGTTCAGTTCCCAGAAGCCTAAAAAACATAACATAATATGCTAACAG
AGCTAATTTCCACCCAATCCCTCAAATTACCGAAGTATTAATATTTAGCTTCCTTTCTAGAAAACAAGGGGCAGCACAAATGGGGTGGCA
TCCATCTCTTTTAAATCACTGATGATTTTCTGGGGAAGTATATATAGATGATTTTATTTTTTAAATAGCCTTTTATCAAACCATTTCACA
TGTATTATCTATATGACTATAGAAACTTATAAAACATTTAATTCATGTTGACTTAAAACATGGGCATCCTTGGATTCTCCACATTGACTG
AAATGATAGAGAAAGGGACATTTGTTTGAGAAACAAGAGACCTGTACCTAATTATGGCAAGTATATGAGTTTTGGTGATTGTGGGGGGTT
ATAAATGTTTTCCTATGATAGATAAATATATAGATATAGATCAGGAATTACTTGATGTCTCTTCAGAAGTTTTCTGTTTTCTTATAATTT
CCAGTAATACTCTGTAAGACTCGGTTTGCATGCTGTGTGTGTTTGCATGAGTATAGAAACCTAAGAACATAATGGAAGGCTATTAAGGCA
AATTCATTCCTAGAAAGTGGAGTGGATCATTGGGATAAGAAATAGCCTAATTATAAACAAATATGCAGGCAGAGGGAAGTCCTAATACAA
TGAAAACTTGCATTATCTAAACAGATGTTCCCAAAGCAATAGTTTGCCTAAAATCCTCTGTATTACATGATTATTCAGTAAAAGAGTAAA
CAAATATCTAATTTATTTTCTAATTGTCCTTCCCTTCATTGAGTATTAACTAGGTGCATAATGTAGTTGTATATGTTTACTAGTAAAGGG
AAAAACACTTATTTTCATTTTGAGACTGTTTGGCTATTACTAAAGCTGAGAAAGTGATTTTAGGTCGCCAAGGATACTATGATTTGATGA
GATGAGAAGAAATCTGCGGTGGCTGAAAATCGTGACCAACTTGGTGTTATCTAGATCTGCTTTATCTAGTTTGCAAGCCATAGGCTCAAT
TTTATGTCCTTCTTACTTACACACAGTAGCCCCACACAGTTTTGTTTTAAATGAAGGCAAAAGTAGACATTTTTAAAGTATATTCAACAT
TGTGCCATTATTTACCTGATAAAGGTGAAATCAGAGGTGTCCACGGCCTCAAAGTTTGGGCCCATGGGACTATCAAATCCGAATTATATC
TACTTAGAGCTTAGAGGAAGAATTAGGTATCATGAGAAAAGCAACTCCTACTTGAGAGAAAGAAGACTACCAAAGCATGTTGAGGCTTTA
ACATGGGAGACTTCCAGGTAGGCGTTAACACTTGAGTGGTAACTAGCTTGATGAAGGAAAATAATTACTTTAGCAGTTATGTTGTAAAAT
TAATAAAAAGGACTCATGTTTATTCTGGTGTATTTGTCAACCCATGGGTAGTGATTACTCCGTGTACATTCTATAGTGTGTGTATTTTAT
TTAGTGTCTTAATATATAGTCTTTATATAGTATCTTAATATTATTTACTGTTACTTCTAGTCATTTATGTAGTATATTTTACTGCAAAAT
TTGTAGCACTTTACTAATATTAGATCATTATTTTCCCTCTTCCCCTCTACCTTTCTGGCATTTTCTGTTATCTTAGAGTCAGGAATCTAA
AGGTCTAAGTCTAGAAATCTGTTGGAAGCTGGGTTGGAGCTACTGGATATGAGTTACTTTTTACATGTCTCCTTAAGAAGACTCTTTTAT
AATGTAATACTTAGAAGCCAAATCCTTTCAAACGCAAACACCCTTGAAACTTGATGCTTTCTGAAGTTGTATTCATAAAAATTATCCCAT
CTTACAGTTAATCAGAAGATGTTCTTACCTTTGGTTTGCCTGCCTCCTGAAACACAAACCTGCAGATTGCCCCTAACTTCAGCAGTGCCT
CCGTCACTGCATGTACCTAAAAGACAGGAAAGCCAAGTTCTGGGAGCTGTCAAGTCGGAGGATCAGGAAAATGGTGGGGAAGAGGTGACT
GGAAAGGCAGGCACTAAAGATGGCAGGCTGCAAAAGCATTCTGAGTTCCCCTGTAACAGATAGGTTTTATGAACTCAGCTGTTTTCTTTT
TTCTTTTTTTTTCTTTTGAGATGGAGTCTCACTCTGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGC
AGCCTCCACCTCCCGGTTTCAAGTGATTCTCCCACCTCAGCCTCCCGAGTAGTTAGGATTACAGGTGCCCACCACCACGCCCAACTAATT
TTTGTATTTTTAGTAAAGACAGGGTGTCGCCATATTGGCTAGGCTGGTTTTGAACTCCTGACCTCAGGTAATCCACCCGCCTCAGCCTCC
CAAAGTGCTGGGATTATTATAGGCGTGAGCCACCATGCCCAGTGAACTTGGCCATTTTCTTACATTCATATATAGCAAAGTTTTCAACTT
GTCTACCGAGAGACTTTCTTTAGGAGCCAGGACTTCTACATTTGTAACTTGAGTATATTAATATTCAAATCATAGTTCAAAAATACTGAA
ATACTTGTTTATTATGTTACATAAATATGGACACAATTACTGCCAAAGAATAGAGAGATTTGCTTATGAGAACATTCTGTCATTTGTTCT
GTTTGTAGATGAGAGACATGCTTTTAAAGTACAAAACGTTTCTCTTCTACCTTACCCCCTGTTCTACTGACGTGCTTTGCATGAGAAGCT
CATCTAGAAGAGAGCAACGCTGGAATAGAGAAGTCTAGACCCTGGCCTTTGAGGGAAAGGACTGCTTTTTTTCTCTCCCAAATTAGAAAA
TTAAAAGTGAAACATAACACATAAGGACGAAATACAATGTTCTGAATATCTTCCACTAATTAATTGTTGAATGATTAAGTCTCTAAGTAT
CTTAACTTCCATTGTCTTCTTGTTAACCTAGACAAGAGTAGATTATTCAGTAGCCACATGTGACAGTTAAAATTAAGTAAAATTAAAACT
ATAGTTTCTCAGTGGCCTAGCCACATTTCAAGTGTTCCACAGTCACATGTGGATAGTAGTTACCTATCAGACAGTACAGGTATAGAACAT
TTCCAGTATTGCCAAAAATGCTATTCAACAGCACTTTTATTGCCCAGAGAGAAAATAAGGACAAAATAAAGGCAGTGAAGTAACTTAAGA
CAACTCTGAGATTTTACCACCATACTTAGAGAAAGTTTTTCTGTTATAAAAATTAATACTAATCCTTTTTAAAGACCTTGGAAAAAATCA
AAACCCCATTCCTTTAAGCTAGTCTTCAGTATATATTTTTCTAAGAACAGATTCTCAATACTTTATTTTTCAAGTGATAAAATCATTTTA
TAAATCATTTCTTAATATCTTCAGTGTTTTTTCCCTTTTTATGTAAACTCTTTTAAAATTGATATTAGCTGGGCATGGTAGCTCATGCCT
GTAGTCCCAGCTACTCCAGAGGTCGAGGCAGGAGCATCGCTTAAGCCCAGGAGGTTCAGGCTGCAGTAAGGTCTGATCACACCTGACTGC
ACTCCAGCCTGGGTGGCAAAGCAAGACCCCTGTCTCTAAAAAAAAATAATATAAATTGATGTTATATAGTTAACATTTATCAGGCAAATT
CATATGAATGCTTATTTCAAATAAAGATTGATAGATTTAATGATATCCTTCCTTTTAAATTTATATAGATCTAATGAACATTGCCAACAG
TTTTTTTTGTTTCTGTCCCTTAAACATTTCCCCTGAAAGTCCACCTCAAAGGTACATCAAGATGCAAACAATTTTTTTATCTTCATAACT
TCCTGCTCTTATTAACTTGTATTATGAATCAAATTAAGTTTTATGTATAAGGCATTTACTATTCCAGTGACTTAGCTAATGAAAACATTT
AAAAATATGTATTAATTTACTTGGCCTGCTACTAAAGTGCTTAACATAACTAAATGGATCTATAGTAACATGTCTAAATTTTTTAATGGA
AATAAGGGACTAACCATAATCCTTTTGAGTCAGCTTGGTGCTTACAATTATTTTGTTAGGAAATCTTGATGCTTTCTTCTTTCTCTTTAA
ATTTTTGTAATCAAGCAACAGACTTGATCCAGCAGTGTCGAATTCCAAGCAAGTTATGATGATTCTTATTGTAGTTCAAGTACAGATGAG
TAAGTGGTGTGACTTCAGTTTATTATCTTCTTGGTGACCTACTTTAGTATGTGTTCTGTAGCGATTCATATTAGTTAAGGGACGTTTTCA
ATATGCTTGAAATAAGAAATAGCATTTTACTCTAAATACAAGAAATGACTGTACACAAATGCTAATCAGTGATTTGGGGCCTTTTAATGT
CTTTAACAGCAATCTTTTATTTATTTATTTATTTATTTTTGAGACGGAGTCTTGCTGTGTCACCAGGCTGGAGCAGTGGCACGATCTCGC
CTCACTGCAACCTCCGCCTCCCAGGTTCAAGCTATTCTCCTGCCTCAGCCTCCCAAGTAACTGGGACTGCAGGCACATGCCACCACATCC
AGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTGGCCAGGATGATCTCGATCTCTTGATCTCGTGATCTGCCCGCATTG
GCCTCCTGAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCCAAATCTTTTATTTTTTAACAGCCTTAGTTATTTATAATTCAA
ATGCACTAAAATATCATCGCTGTCATGAACTTTGCTGTTTACAGGTTCTGTGTAATTCAGAATGCTTTGTACTTAGAAAATAATTTCTAG
GCTTATCTTGTTTTGCAGTTTTCATGTTTTGACAATTGCCCACCATTTACAATACTCAATTTTTGATTATGAAATGAATAGTAAAATTCA
AACATATCTAATAATAATTTGCCTTAGTTTGATTAATAAATTATATCAAAAAACTTGGGGATAGAAAGAGGCTTTTTTTTCCCCCTGTAG
TATTTTTAAAACTTTTTAGATGAGCTGGATGAAACCTTAGTACATTGGAGCTGGAGTTGTATTGAGTACAGCCCCAACTCTGAAGCCTTA
TATTCATGTCTTAAGTACCATTGATTGTTCTGTGAATTGTTGTTAGTTTCATATTTGACATTGTAGTAATCCACCTTGCATTTTAGTCTT
TGCAAAAAGGATATTGCTAGGTATATTCTTATTTCTGATTGAGTATTGAATTTACATTTTTCAGAATTTCATTCTTTGTCATTATAATCC
AAAAACAATGTCCACATCAGACTTGGAACTTCTCACTTCAAAAATGAAATACAGATTTAGCAGTGTTGTACATAATGATGTCCAAGCATT
TTTCCACCTGTTTACTGAGTTTTCCAACCATTTACTATGTGTTGAGATTGGTGGGTTTTCTGGCTGTTTTTCTGAGGTGAATGACTTGTT
ACAGAGCCTCAGTAAGAAATTTCAACTAAAATCACAAAAACATAAAGTCCAGGAAACCACCAGAAGATGGATTTTTAGTGTTTTTGAAAT
CTTGTATTTCCTTTTGATATCATTTACTCATTTTAATTTTACGACTGCCAACTTGTTACGGTATTAATTATATGTATGTGTTTATATGTA
TGCATATAATATATGTATATGTATATGAAGAATAAAGTTAAGATTTGGTCAAACTATATTTTCCCATTCAAGTACAAAAATGTTTTCAAG

>95482_95482_3_TUSC3-HOOK3_TUSC3_chr8_15398077_ENST00000506802_HOOK3_chr8_42819454_ENST00000307602_length(amino acids)=575AA_BP=52
MGAHGYRAWRRHCPAAMGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKEVAALQEEKSSLLAENQVLMERLNQSDSI
EDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESY
KKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRL
RTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRK
NELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKK
EEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAED

--------------------------------------------------------------
>95482_95482_4_TUSC3-HOOK3_TUSC3_chr8_15398077_ENST00000509380_HOOK3_chr8_42819454_ENST00000307602_length(transcript)=13871nt_BP=288nt
CTCGGCCGCGGCCCGGGTCCCTCGCAAAGCCGCTGCCATCCCGGAGGGCCCAGCCAGCGGGCTCCCGGAGGCTGGCCGGGCAGGCGTGGT
GCGCGGTAGGAGCTGGGCGCGCACGGCTACCGCGCGTGGAGGAGACACTGCCCTGCCGCGATGGGGGCCCGGGGCGCTCCTTCACGCCGT
AGGCAAGCGGGGCGGCGGCTGCGGTACCTGCCCACCGGGAGCTTTCCCTTCCTTCTCCTGCTGCTGCTGCTCTGCATCCAGCTCGGGGGA
GGACAGAAGAAAAAGGAGGTTGCAGCATTGCAGGAAGAGAAAAGTAGTTTGTTGGCAGAGAATCAGGTATTAATGGAAAGACTCAATCAA
TCTGATTCTATAGAAGACCCTAACAGTCCAGCAGGAAGAAGGCATTTGCAGCTCCAGACTCAATTAGAACAGCTCCAAGAAGAAACATTC
AGACTAGAAGCAGCCAAAGATGATTATCGAATACGTTGTGAAGAGTTAGAAAAGGAGATCTCTGAACTTCGGCAACAGAATGATGAACTG
ACCACTTTGGCAGATGAAGCTCAGTCTCTGAAAGATGAGATCGACGTGCTGAGACATTCTTCTGATAAAGTATCTAAACTAGAAGGTCAA
GTAGAATCTTATAAAAAGAAGCTAGAAGACCTTGGTGATTTAAGGCGGCAGGTTAAACTCTTAGAAGAGAAGAATACCATGTATATGCAG
AATACTGTCAGTCTAGAGGAAGAGTTAAGAAAGGCCAACGCAGCGCGAAGTCAACTTGAAACCTACAAGAGACAGGTAGTAGAACTACAA
AACAGATTATCCGAAGAATCAAAGAAAGCAGATAAACTAGATTTTGAATATAAGCGGCTAAAAGAAAAAGTTGACAGTCTTCAAAAAGAA
AAGGACAGGCTGAGAACAGAAAGGGATTCTCTGAAGGAAACCATTGAAGAGCTTCGTTGTGTACAAGCTCAAGAAGGGCAGCTCACAACA
CAAGGGTTAATGCCTCTTGGAAGTCAGGAGTCTTCAGACAGTCTAGCTGCAGAGATTGTTACACCTGAAATCAGGGAGAAACTTATTCGT
CTTCAGCATGAGAATAAGATGTTAAAGCTTAACCAAGAAGGTTCGGACAATGAAAAAATAGCCTTATTGCAGAGCCTTCTAGATGATGCA
AATCTACGCAAGAATGAACTGGAGACAGAGAATAGGCTGGTGAATCAAAGACTTCTGGAAGTACAGTCACAAGTTGAAGAATTACAAAAA
TCTTTACAGGATCAAGGCTCAAAAGCAGAAGATTCAGTCCTTCTAAAAAAGAAGCTTGAAGAACATCTAGAGAAGCTGCATGAGGCCAAT
AATGAACTACAGAAGAAGAGAGCCATTATTGAAGATCTCGAGCCAAGATTTAACAACAGCTCCTTAAAAATTGAAGAATTACAAGAAGCT
TTACGAAAGAAAGAGGAAGAAATGAAGCAAATGGAAGAACGATACAAAAAATACTTAGAGAAAGCCAAAAGTGTCATCCGTACTTTAGAT
CCTAAACAGAATCAAGGAGCAGCACCAGAAATACAAGCTCTTAAAAATCAGCTCCAGGAACGAGACCGACTGTTCCACTCATTAGAGAAA
GAATATGAGAAAACAAAGAGTCAGAGAGAGATGGAAGAGAAATATATTGTTAGTGCCTGGTACAATATGGGAATGACCCTGCATAAAAAG
GCAGCTGAAGATAGACTGGCAAGCACAGGCTCAGGGCAGTCATTTCTGGCGAGGCAGAGGCAAGCGACCAGCAGCAGAAGATCATACCCA
GGCCACGTGCAGCCGGCCACAGCAAGGTAGAGAAGTTGTGCCGCTCAATCACAGACACCTGCACCCACAACATACTTCTGTTACACACAA
GAACATTTCAGGAAACTCAGCCAGCTTATTTTTTGTTTCTCTTCTATGTCAATACTTAGTGTTTCTCATTTTGAGGACTTTTTCTCTCTC
CTGTATCTTTGTTTTAGTTTCTTTGGTTTTTATTTTGTAGTCCTTTCAGTTATTTTTAATGTGCCAAAAATTTGTACATGTTCAATTAAA
AATGTTGTATAATAGTGTAATACTTTTCTTTGTATGAAAATGTCCTCTTCTTCAAAGGTATAGGCTTTGTAATGAATTAGATTTTCTGCC
AATAATTGATATACAATTTATATTCTTTATTGTGCCTGTGTGTTACCATGCTAAGAATGTCTTTGTTTAAAGGGAATTAATCTTTTTATG
ATGTATTAATCTGTGTTTTCAATTGTTTTCCAAGTACAGTTCAAATAACTTGCATATTTACTATACAAAATGGTTGACAAGTGTTCTTTT
TGCAAAGACTTGAATACATTGGCAGAGGTGCTAATCACATCTTCCCTAAGGCACCTGGAAGAATTATTTGAGGAAAAAATGAGTTTTCAC
ATTGTTTTATAGGAAATTAAATTTGTCCAAAGATTTGGAGACTATTTTTAAAACATAAATACATAAAATTTCATTATTTCCTGCTATCTT
GTTTGCTGGCAGAAGTGAATGTTTGGTGAGGTTATTTTGGGATAAATTACAAAAGAAAAAAAATTAGACACTGCATTAATTTCTTGTTCT
TTTGGAATATCTTAGTAACTGAGGATCATTTTCTAACAATGTGGTTGACATACCTTCAGTTGCTTTCCACATCTAAAAGAGTTATCTTTC
ATATATGTACAAGTTATTGGTAGTCTTATTTTTGGGCTGTTTGTTGACTTATGCCCCATTTGTTTTACTTGTTCTTTAATATAAACCCTT
CCATTTTTTAACAATTCCTAACACTTGATATCTTAATATCAGTCACTAACATTAGTAACTTCTTGTATGTTATATTATGGCAGATCTCTT
TACGTTTTTTCTCACATCTATCTGCTAGTCCAGGAATTTGTTACTAAATAGATTTTCTTGGATATTTGGTTGCCTCAAAGTGCTTACATT
TGTTAACAGATTGTAAACCACATTTATTTACATTGATGAATGGGCTGTTGAATAATCATTGTAAAGCACTTTGTATATATAAGGTGCTAT
ATAAGTGTGAAATATCATTCATTTATAAATGAAATGCCTTCTAACTTTCCATATTGACTTATGTATTTGGTCCCAAATTATATTTAAGTC
TTTTTTCTTGCAACGTAGCCCATTTTTTGAAAGCAAAACATTTCTGAAATTAGGTCATGGTTTTTTTGTTTATTTTTAGGTTAGGTCACT
TAATATAGGAGGATGTTTTCTCATGTACTTGCTATTTGCAAGTTCAGGTTTCATTTGGTTCTTTATGTTAAATACGAATAAGTAACCTCA
AATCAAGCTAAATGTAATTAAGAATTTTCAGCAACTATATTCAAGTGTTTGATTTTTAAATTCTTTCTTTCTTTTTAATAAGAAAGATGA
CCTAAAAATCAGTGGTATTTGTTTGTCCTCAGAAGCCGTAGTTGAAGAAAGATATTAGAGTATACACAGAACTGGAGCCATACATTGTGC
TAATTTTTTACATTAAGTACAGAAGTCTGAGCACAGCATGAATGCTTCTGCCTGACAGGACCACAAAGCAGCAGAAGTTAGGGATAAATG
GAGATAGCCATGAGTAGAACTGCTGTAGGGCTTCAGGAGGCTACGCAGACCTGATCAACTGCAAAGTTTCCAAAGTAAAAGATTAAAAAC
TTTCAGACGGTTCTTACCTCTACCCGTGTTTCACAAATAGCCTGAGGATCCAACTATTTTTAAAGCAAATTGGGGCCAGACGTGGTGCCT
CACGCCTGCAATCTCACCATTTGGGAGACCTAGGTGGGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAA
ACCCCATCTCTACTAAATTACAAAAATTAGCTGGGCATGGTGGCATGTGGCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAGTC
ACTTGAACTCAGGAGCCAGAGACTGCAGTGAGCTGAGATCGCACCACTGCATTCCAGCCTGGGCGACAGAGTGAGACTCTGTCTCAATCA
GTCAATCAATCAATCAATCAAATTGGAATATGAGCACTAACCTTGGTAAGTTAAAATTTTGGGAAAATTGTACCTGCAGAATATGATGGA
TGAAAACAACAGCCAGGTGCAGTGGCTCACGCGTATAATCCCAGCACTTTGGGAGGCCGAGACAGGCACATCATCTGAGGTCAGGACTTC
CAGACCAGCCTGTCCAACATGGTGAAACTCCGTCTCTACTAAAAATACAAACAATTAGCCAGGCATGGTGGTGTGTGCCTGTAGTCCCAG
CTACTTGGGAGGGTGAGGCAGGAGAATTGCTTGAACCTGGGAGACAGAGATTGCAGTGAGCCGAGATGGCGCCATTGCACCCCAGCCTGG
CGACAAGAGCGAAACTCTGTCGCAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAACAGTCTGTGAACTACTCACTGAATGAATTTTGTTC
TGTGAGATGAGAGGTTTTCATTTTCATTTTCTATTTACAGCCCCAGTCCTAATCTCCTACCCATCCACCTACCCAGATATTTTTTCTCTA
TCTGGGTTGGAAAGGCCCCAGGCTTTTAGAGGGGAGTTTTACTTCTGACTTTTTTTTCCCCCCGAGACGGAGCCTCGTTCCGTCACCCAG
GCTGTAGTGCCGTGGCATGATCTCGGCTCACTGCAGCCTCTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCAGAGTAGCTGG
GATTACAGGTGCCCACCACCATGGCTGGCTAATTTTTGTAATTTAGTAGAGATGGTGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTC
CTGACCTCGTGATCTACCCACCTCGGCCTCCCAAAGTGCTGAGATTACAGGCACGAGCCACCGCGCCCAGTCGTACTTCTGACTTTTCTT
CAGCATCTGTTGTATGCTATTATTTTGATGTTTACATTTATAATTTTCTTTCTTTTTTTTTTTTTTGTGAGATGATGTCTCGCTCTGTCA
CCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTA
GCGGGGACTACAGGCGCCCGCCACTACGCCCGACTAATTTTTTGTATTTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTC
TCGATCTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAGAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTACATTTATA
ATTTTCATTCTCTTTTACCTATAAAATTCAGTGTATTAGTTTCATTACATAGGAGAAATTATATTTCTAAACATTTTATGATGTTTAAAA
ACAAAACAGGCTGTTGTAAAAAAAAAAAAAAAAAAAACTTCTGAATATACTTTAGGTATCAGAAAGCCAAGAATAAAATTTAGCTCTAAC
GGTGGCAACTCCATGTCCGGTGTCCAGCTTTGGACAGGGTTTATGACGTTTCTGTTTCTCTAGTAATGATTAATGATTCCTCAGGAGATT
CGTGATGTTGTCTGGTCTATCTGGAAATTTAAAGTCACTAGGAGCTTTGCCTCATCGTGAGTGATGCTGTGCTGTATTTTTACAAACTCT
CGCATACAGCACCTTCCTGGGGCCACGTTGGCTTGTGCAGTGGAGCTTGTCCAGGCACCAGCATGGAGCAAGTACAGGGTTGCTGTGTTG
GGTTGGAGCACACTGTCACCACAGTGTCTGAAGTCTTATAAACAGGAAGATCATTTTCTGTTTTCCTTCTAACCAGGGTGAGAAAATACA
AAGTAAAGAACTAAAGAATATTAAAACCTAGCATTTATGTTCCACAGTGTGTATTTCAGAAGTTTGTAATCCAGAAAATATAGTAGTGTA
TAATATCTGAAAAGAGAATCAAGTATACAATTGTACATATTTTTAAAGAACTTTGAAAAACTCCGTCATATCTTTTACCATTTGTCTATT
TGATAGTAATGCAGAAAAAAGTCCCTAAAGACCCTGTGTTCCAAAATTTACCAAGATTGACATTTCTATTAGACATCCTTAACCTAAGTG
TTTTAATTAGATTATTAGACTATAATAAGGATGAAATTGCTGTCTGTAATTTTGTTGAGGTTTTATTGTTAATATAATAAAAGCTCAACT
GTACAAAATTAAGCTAAATGTTATCCAGTCAGAAACATCAGCCTGTGGCCAGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGA
GGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCTAATATGGTGAAACCCCATCTCTACTAAAAATACAGTATT
AGCCAGGCATGGTGGCAGGCGCCTGTGATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCATGTGAACCCAGGAGGTGGAGGTTGCAG
TAAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGCCACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAGAAACATCAG
CCTGTATATTCCAGTAGTTCTCACAGAAGAATGAAAATCCGTGCTGTGCAAATAGATCAGTAGTGAGTGAGTGTTAAGTGAAAGATGAGC
TAGGTTGAAGAAAATATACATTTTATTGATGAGCCACTTTGCTATCTCTCCTTCCTTCCTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCC
TTCCCTTCTTTTCTTTTTTCTTTTCTTTTCTTTTCTCCCTCCTTTCTTCCTTCCCTTCCCTTCCCCTCCCCTCCCCCAGGCTGGAGTGCA
GAGGCACGATCCTGGCTGACTGCAAACTCTGCCTACCAGGTTCAAGCGATTCTCCTGCCTCATCCTCCCTAGTAGCTAGGATTACAGGCA
TCTGCCACCACGCCCAGCTAATTTTTGTATTTTTACAAAATACAAAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCTAACTCCT
GACCTCAGGTGATCCGTCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGTGTTACTGCCCCAGCCTCCTATTTCCTTTTCGAAA
GTAGCAGTTTGGTTTATTCTCGTTTGCTAAGTAATTGTTTGAAATATTTTTCAGCCTCTCCTGCTCCCTCACAAAAATTCACCTGTCATT
TTAATGATAACAGCATGTTAAAAACTTGGAAGTCTTTATCCCAATATAAGAATTATCTTGAAACAAAAATCTAAATTACTTTTAAAAATT
CTCTTAACTCTGCATTTAGTCTCCTATTATCTAGATCTCTGAGTCCAGGATAACTCCAGTTATCCCCAGTTGGATCATGTGTGATTTATC
TGAGAAAGCATCCACAACCCACAGCTAGTGGAAACCGAGCTAGTTTACAGCCACGTGGATAAGAACATCTTTGTTTCTAAAGTGAGAGGA
AAGTGCTTGGTATCTTGCTTTTTGCTGAGGGCAAAATAACAACATGAAGACAAAGTGCTTTTTGTTGTCTATTCATGAAACTGTAGAAGA
ATATTTTGAGTTTTTATTCTTATATTATGAAGGGATTCTTTGCCTAGCAGTGGCCGTCAAACTGATGTAGCATTGTACTTCTCAACAGTG
AAGCCTGTGTAATACCATACAGTAGGATGAAAGACTATTCTGAGCAAAATCAAATGGGATGTCAGAATCTTTGAAAATTATTTTATCATT
TTTTCTATTTTTTCATTTTTATAAATTAGAAGGATTTTCCATTCAATAAGGATAATCTCTCTTCCTATCATTCTGTCAAAATGGCAGTTT
CTTTTGGTAATTATCCAACCTAGTTTCATTACATTTAGAAGGAGGTTTCAGAGCTTATTCTTGATAACTATAATAATGATTTGAATGTTT
TATATCATGAAGTTTTTTCTATGAGGAAGGCTATTCTCAATGTATCTGTCGTCTAATTTTTTATTTTCTATCTATAAAGAATATTTAAAT
AATAATTGGTGTATGTTCCTTTTGTTGAAAATGTTTTATTGTCCAGTTTTAACACAGAAGTGGTCTAAAGTTTTGCAGCAAATGCTGTTC
AGTTCCCAGAAGCCTAAAAAACATAACATAATATGCTAACAGAGCTAATTTCCACCCAATCCCTCAAATTACCGAAGTATTAATATTTAG
CTTCCTTTCTAGAAAACAAGGGGCAGCACAAATGGGGTGGCATCCATCTCTTTTAAATCACTGATGATTTTCTGGGGAAGTATATATAGA
TGATTTTATTTTTTAAATAGCCTTTTATCAAACCATTTCACATGTATTATCTATATGACTATAGAAACTTATAAAACATTTAATTCATGT
TGACTTAAAACATGGGCATCCTTGGATTCTCCACATTGACTGAAATGATAGAGAAAGGGACATTTGTTTGAGAAACAAGAGACCTGTACC
TAATTATGGCAAGTATATGAGTTTTGGTGATTGTGGGGGGTTATAAATGTTTTCCTATGATAGATAAATATATAGATATAGATCAGGAAT
TACTTGATGTCTCTTCAGAAGTTTTCTGTTTTCTTATAATTTCCAGTAATACTCTGTAAGACTCGGTTTGCATGCTGTGTGTGTTTGCAT
GAGTATAGAAACCTAAGAACATAATGGAAGGCTATTAAGGCAAATTCATTCCTAGAAAGTGGAGTGGATCATTGGGATAAGAAATAGCCT
AATTATAAACAAATATGCAGGCAGAGGGAAGTCCTAATACAATGAAAACTTGCATTATCTAAACAGATGTTCCCAAAGCAATAGTTTGCC
TAAAATCCTCTGTATTACATGATTATTCAGTAAAAGAGTAAACAAATATCTAATTTATTTTCTAATTGTCCTTCCCTTCATTGAGTATTA
ACTAGGTGCATAATGTAGTTGTATATGTTTACTAGTAAAGGGAAAAACACTTATTTTCATTTTGAGACTGTTTGGCTATTACTAAAGCTG
AGAAAGTGATTTTAGGTCGCCAAGGATACTATGATTTGATGAGATGAGAAGAAATCTGCGGTGGCTGAAAATCGTGACCAACTTGGTGTT
ATCTAGATCTGCTTTATCTAGTTTGCAAGCCATAGGCTCAATTTTATGTCCTTCTTACTTACACACAGTAGCCCCACACAGTTTTGTTTT
AAATGAAGGCAAAAGTAGACATTTTTAAAGTATATTCAACATTGTGCCATTATTTACCTGATAAAGGTGAAATCAGAGGTGTCCACGGCC
TCAAAGTTTGGGCCCATGGGACTATCAAATCCGAATTATATCTACTTAGAGCTTAGAGGAAGAATTAGGTATCATGAGAAAAGCAACTCC
TACTTGAGAGAAAGAAGACTACCAAAGCATGTTGAGGCTTTAACATGGGAGACTTCCAGGTAGGCGTTAACACTTGAGTGGTAACTAGCT
TGATGAAGGAAAATAATTACTTTAGCAGTTATGTTGTAAAATTAATAAAAAGGACTCATGTTTATTCTGGTGTATTTGTCAACCCATGGG
TAGTGATTACTCCGTGTACATTCTATAGTGTGTGTATTTTATTTAGTGTCTTAATATATAGTCTTTATATAGTATCTTAATATTATTTAC
TGTTACTTCTAGTCATTTATGTAGTATATTTTACTGCAAAATTTGTAGCACTTTACTAATATTAGATCATTATTTTCCCTCTTCCCCTCT
ACCTTTCTGGCATTTTCTGTTATCTTAGAGTCAGGAATCTAAAGGTCTAAGTCTAGAAATCTGTTGGAAGCTGGGTTGGAGCTACTGGAT
ATGAGTTACTTTTTACATGTCTCCTTAAGAAGACTCTTTTATAATGTAATACTTAGAAGCCAAATCCTTTCAAACGCAAACACCCTTGAA
ACTTGATGCTTTCTGAAGTTGTATTCATAAAAATTATCCCATCTTACAGTTAATCAGAAGATGTTCTTACCTTTGGTTTGCCTGCCTCCT
GAAACACAAACCTGCAGATTGCCCCTAACTTCAGCAGTGCCTCCGTCACTGCATGTACCTAAAAGACAGGAAAGCCAAGTTCTGGGAGCT
GTCAAGTCGGAGGATCAGGAAAATGGTGGGGAAGAGGTGACTGGAAAGGCAGGCACTAAAGATGGCAGGCTGCAAAAGCATTCTGAGTTC
CCCTGTAACAGATAGGTTTTATGAACTCAGCTGTTTTCTTTTTTCTTTTTTTTTCTTTTGAGATGGAGTCTCACTCTGAGTCTCACTCTG
TTGCCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAGCCTCCACCTCCCGGTTTCAAGTGATTCTCCCACCTCAGCCTCCCGA
GTAGTTAGGATTACAGGTGCCCACCACCACGCCCAACTAATTTTTGTATTTTTAGTAAAGACAGGGTGTCGCCATATTGGCTAGGCTGGT
TTTGAACTCCTGACCTCAGGTAATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTATTATAGGCGTGAGCCACCATGCCCAGTGAACT
TGGCCATTTTCTTACATTCATATATAGCAAAGTTTTCAACTTGTCTACCGAGAGACTTTCTTTAGGAGCCAGGACTTCTACATTTGTAAC
TTGAGTATATTAATATTCAAATCATAGTTCAAAAATACTGAAATACTTGTTTATTATGTTACATAAATATGGACACAATTACTGCCAAAG
AATAGAGAGATTTGCTTATGAGAACATTCTGTCATTTGTTCTGTTTGTAGATGAGAGACATGCTTTTAAAGTACAAAACGTTTCTCTTCT
ACCTTACCCCCTGTTCTACTGACGTGCTTTGCATGAGAAGCTCATCTAGAAGAGAGCAACGCTGGAATAGAGAAGTCTAGACCCTGGCCT
TTGAGGGAAAGGACTGCTTTTTTTCTCTCCCAAATTAGAAAATTAAAAGTGAAACATAACACATAAGGACGAAATACAATGTTCTGAATA
TCTTCCACTAATTAATTGTTGAATGATTAAGTCTCTAAGTATCTTAACTTCCATTGTCTTCTTGTTAACCTAGACAAGAGTAGATTATTC
AGTAGCCACATGTGACAGTTAAAATTAAGTAAAATTAAAACTATAGTTTCTCAGTGGCCTAGCCACATTTCAAGTGTTCCACAGTCACAT
GTGGATAGTAGTTACCTATCAGACAGTACAGGTATAGAACATTTCCAGTATTGCCAAAAATGCTATTCAACAGCACTTTTATTGCCCAGA
GAGAAAATAAGGACAAAATAAAGGCAGTGAAGTAACTTAAGACAACTCTGAGATTTTACCACCATACTTAGAGAAAGTTTTTCTGTTATA
AAAATTAATACTAATCCTTTTTAAAGACCTTGGAAAAAATCAAAACCCCATTCCTTTAAGCTAGTCTTCAGTATATATTTTTCTAAGAAC
AGATTCTCAATACTTTATTTTTCAAGTGATAAAATCATTTTATAAATCATTTCTTAATATCTTCAGTGTTTTTTCCCTTTTTATGTAAAC
TCTTTTAAAATTGATATTAGCTGGGCATGGTAGCTCATGCCTGTAGTCCCAGCTACTCCAGAGGTCGAGGCAGGAGCATCGCTTAAGCCC
AGGAGGTTCAGGCTGCAGTAAGGTCTGATCACACCTGACTGCACTCCAGCCTGGGTGGCAAAGCAAGACCCCTGTCTCTAAAAAAAAATA
ATATAAATTGATGTTATATAGTTAACATTTATCAGGCAAATTCATATGAATGCTTATTTCAAATAAAGATTGATAGATTTAATGATATCC
TTCCTTTTAAATTTATATAGATCTAATGAACATTGCCAACAGTTTTTTTTGTTTCTGTCCCTTAAACATTTCCCCTGAAAGTCCACCTCA
AAGGTACATCAAGATGCAAACAATTTTTTTATCTTCATAACTTCCTGCTCTTATTAACTTGTATTATGAATCAAATTAAGTTTTATGTAT
AAGGCATTTACTATTCCAGTGACTTAGCTAATGAAAACATTTAAAAATATGTATTAATTTACTTGGCCTGCTACTAAAGTGCTTAACATA
ACTAAATGGATCTATAGTAACATGTCTAAATTTTTTAATGGAAATAAGGGACTAACCATAATCCTTTTGAGTCAGCTTGGTGCTTACAAT
TATTTTGTTAGGAAATCTTGATGCTTTCTTCTTTCTCTTTAAATTTTTGTAATCAAGCAACAGACTTGATCCAGCAGTGTCGAATTCCAA
GCAAGTTATGATGATTCTTATTGTAGTTCAAGTACAGATGAGTAAGTGGTGTGACTTCAGTTTATTATCTTCTTGGTGACCTACTTTAGT
ATGTGTTCTGTAGCGATTCATATTAGTTAAGGGACGTTTTCAATATGCTTGAAATAAGAAATAGCATTTTACTCTAAATACAAGAAATGA
CTGTACACAAATGCTAATCAGTGATTTGGGGCCTTTTAATGTCTTTAACAGCAATCTTTTATTTATTTATTTATTTATTTTTGAGACGGA
GTCTTGCTGTGTCACCAGGCTGGAGCAGTGGCACGATCTCGCCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCTATTCTCCTGCCTCAG
CCTCCCAAGTAACTGGGACTGCAGGCACATGCCACCACATCCAGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCTTGTTGGCC
AGGATGATCTCGATCTCTTGATCTCGTGATCTGCCCGCATTGGCCTCCTGAAGTGCTGGGATTACAGGCATGAGCCACTGCGCCCGGCCC
AAATCTTTTATTTTTTAACAGCCTTAGTTATTTATAATTCAAATGCACTAAAATATCATCGCTGTCATGAACTTTGCTGTTTACAGGTTC
TGTGTAATTCAGAATGCTTTGTACTTAGAAAATAATTTCTAGGCTTATCTTGTTTTGCAGTTTTCATGTTTTGACAATTGCCCACCATTT
ACAATACTCAATTTTTGATTATGAAATGAATAGTAAAATTCAAACATATCTAATAATAATTTGCCTTAGTTTGATTAATAAATTATATCA
AAAAACTTGGGGATAGAAAGAGGCTTTTTTTTCCCCCTGTAGTATTTTTAAAACTTTTTAGATGAGCTGGATGAAACCTTAGTACATTGG
AGCTGGAGTTGTATTGAGTACAGCCCCAACTCTGAAGCCTTATATTCATGTCTTAAGTACCATTGATTGTTCTGTGAATTGTTGTTAGTT
TCATATTTGACATTGTAGTAATCCACCTTGCATTTTAGTCTTTGCAAAAAGGATATTGCTAGGTATATTCTTATTTCTGATTGAGTATTG
AATTTACATTTTTCAGAATTTCATTCTTTGTCATTATAATCCAAAAACAATGTCCACATCAGACTTGGAACTTCTCACTTCAAAAATGAA
ATACAGATTTAGCAGTGTTGTACATAATGATGTCCAAGCATTTTTCCACCTGTTTACTGAGTTTTCCAACCATTTACTATGTGTTGAGAT
TGGTGGGTTTTCTGGCTGTTTTTCTGAGGTGAATGACTTGTTACAGAGCCTCAGTAAGAAATTTCAACTAAAATCACAAAAACATAAAGT
CCAGGAAACCACCAGAAGATGGATTTTTAGTGTTTTTGAAATCTTGTATTTCCTTTTGATATCATTTACTCATTTTAATTTTACGACTGC
CAACTTGTTACGGTATTAATTATATGTATGTGTTTATATGTATGCATATAATATATGTATATGTATATGAAGAATAAAGTTAAGATTTGG
TCAAACTATATTTTCCCATTCAAGTACAAAAATGTTTTCAAGGCTGCAAAAAGTGTACAGTTGTTAAACAAGTTGTAAATAAAGACTTGT

>95482_95482_4_TUSC3-HOOK3_TUSC3_chr8_15398077_ENST00000509380_HOOK3_chr8_42819454_ENST00000307602_length(amino acids)=575AA_BP=52
MGAHGYRAWRRHCPAAMGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKEVAALQEEKSSLLAENQVLMERLNQSDSI
EDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESY
KKKLEDLGDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRL
RTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRK
NELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKK
EEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQERDRLFHSLEKEYEKTKSQREMEEKYIVSAWYNMGMTLHKKAAED

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Fusion Gene PPI Analysis for TUSC3-HOOK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TUSC3-HOOK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TUSC3-HOOK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource