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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TXN-NDST3 (FusionGDB2 ID:95601)

Fusion Gene Summary for TXN-NDST3

check button Fusion gene summary
Fusion gene informationFusion gene name: TXN-NDST3
Fusion gene ID: 95601
HgeneTgene
Gene symbol

TXN

NDST3

Gene ID

25828

9348

Gene namethioredoxin 2N-deacetylase and N-sulfotransferase 3
SynonymsCOXPD29|MT-TRX|MTRX|TRX2|TXNHSST3
Cytomap

22q12.3

4q26

Type of geneprotein-codingprotein-coding
Descriptionthioredoxin, mitochondrialmitochondrial thioredoxinbifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3GlcNAc N-deacetylase/ N-sulfotransferase 3N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3N-deacetylase/N-sulfotransferase 3N-heparan sulfate sulfotransferase 3glucosaminyl N-dea
Modification date2020031320200313
UniProtAcc.

O95803

Ensembl transtripts involved in fusion geneENST00000374517, ENST00000374515, 
ENST00000487892, 		ENST00000296499, 
ENST00000433996, 
Fusion gene scores* DoF score5 X 6 X 3=902 X 2 X 2=8
# samples 62
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: TXN [Title/Abstract] AND NDST3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTXN(113013100)-NDST3(119059209), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNDST3

GO:0015012

heparan sulfate proteoglycan biosynthetic process

9915799

TgeneNDST3

GO:0015014

heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

9915799


check buttonFusion gene breakpoints across TXN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NDST3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-0871-01ATXNchr9

113013100

-NDST3chr4

119059209

+


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Fusion Gene ORF analysis for TXN-NDST3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000374517ENST00000296499TXNchr9

113013100

-NDST3chr4

119059209

+
In-frameENST00000374517ENST00000433996TXNchr9

113013100

-NDST3chr4

119059209

+
intron-3CDSENST00000374515ENST00000296499TXNchr9

113013100

-NDST3chr4

119059209

+
intron-3CDSENST00000374515ENST00000433996TXNchr9

113013100

-NDST3chr4

119059209

+
intron-3CDSENST00000487892ENST00000296499TXNchr9

113013100

-NDST3chr4

119059209

+
intron-3CDSENST00000487892ENST00000433996TXNchr9

113013100

-NDST3chr4

119059209

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374517TXNchr9113013100-ENST00000296499NDST3chr4119059209+47283941391791550
ENST00000374517TXNchr9113013100-ENST00000433996NDST3chr4119059209+11603941391098319

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374517ENST00000296499TXNchr9113013100-NDST3chr4119059209+0.0008145850.9991854
ENST00000374517ENST00000433996TXNchr9113013100-NDST3chr4119059209+0.0026551540.9973449

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Fusion Genomic Features for TXN-NDST3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TXNchr9113013099-NDST3chr4119059208+2.86E-060.99999714
TXNchr9113013099-NDST3chr4119059208+2.86E-060.99999714

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TXN-NDST3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:113013100/chr4:119059209)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NDST3

O95803

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. {ECO:0000269|PubMed:9915799}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNDST3chr9:113013100chr4:119059209ENST00000296499314605_609408874.0Nucleotide bindingPAPS
TgeneNDST3chr9:113013100chr4:119059209ENST00000296499314824_828408874.0Nucleotide bindingPAPS
TgeneNDST3chr9:113013100chr4:119059209ENST00000296499314590_873408874.0RegionNote=Heparan sulfate N-sulfotransferase 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTXNchr9:113013100chr4:119059209ENST00000374515-142_105086.0DomainThioredoxin
HgeneTXNchr9:113013100chr4:119059209ENST00000374517-352_10563106.0DomainThioredoxin
TgeneNDST3chr9:113013100chr4:119059209ENST0000029649931436_589408874.0RegionNote=Heparan sulfate N-deacetylase 3
TgeneNDST3chr9:113013100chr4:119059209ENST000002964993141_13408874.0Topological domainCytoplasmic
TgeneNDST3chr9:113013100chr4:119059209ENST0000029649931435_873408874.0Topological domainLumenal
TgeneNDST3chr9:113013100chr4:119059209ENST0000029649931414_34408874.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for TXN-NDST3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95601_95601_1_TXN-NDST3_TXN_chr9_113013100_ENST00000374517_NDST3_chr4_119059209_ENST00000296499_length(transcript)=4728nt_BP=394nt
CTCGCAGGCTCCAGGGGCGGGGCGTGGCCGGGGCGCAGCGACGGGCGCGGAGGTCCGGCCGGGCGCGCGCGCCCCCGCCACACGCACGCC
GGGCGTGCCAGTTTATAAAGGGAGAGAGCAAGCAGCGAGTCTTGAAGCTCTGTTTGGTGCTTTGGATCCATTTCCATCGGTCCTTACAGC
CGCTCGTCAGACTCCAGCAGCCAAGATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACT
TGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGT
GATATTCCTTGAAGTAGATGTGGATGACTGTCAGGAGCACGGCATTCCAACGGACATGGGCTACGCTGTGGCCCCTCACCATTCGGGCGT
CTACCCTGTACATGTTCAGCTTTATGAGGCCTGGAAGAAGGTCTGGAATATTAAAATCACCAGCACTGAAGAATATCCACATCTGAAGCC
AGCTAGATACCGGAGGGGTTTTATCCACAAAAACATCATGGTTCTCCCAAGACAAACCTGTGGGCTTTTCACTCACACCATTTTCTACAA
AGAATATCCAGGGGGTCCTAAAGAGCTGGATAAGAGTATCCAAGGAGGAGAACTTTTCTTCACTGTCGTCCTCAACCCTATCAGCATTTT
CATGACCCATTTGTCCAACTATGGGAATGACCGACTGGGATTATATACATTTGTTAATCTGGCCAACTTTGTGAAGAGCTGGACCAACCT
GCGACTTCAGACTCTGCCTCCAGTACAACTGGCCCACAAGTATTTTGAGCTGTTTCCTGATCAGAAAGACCCTCTCTGGCAGAATCCTTG
CGATGACAAACGCCACAGAGACATTTGGTCTAAAGAAAAAACTTGTGATCGCTTACCAAAATTCTTGGTAATAGGACCCCAGAAAACTGG
TACCACTGCTTTGTATTTGTTCCTGGTTATGCATCCTTCCATCCTTAGTAACTCCCCCAGCCCAAAAACCTTTGAGGAGGTACAGTTCTT
TAATAGAAATAACTACCACAGGGGGATTGATTGGTATATGGATTTCTTCCCAGTCCCATCTAATGTCACTACCGACTTTTTGTTTGAGAA
GAGTGCCAATTACTTCCACTCAGAGGAAGCCCCTAAAAGAGCTGCTTCTCTGGTTCCCAAAGCCAAGATTATCACCATTCTCATTGACCC
TTCAGACCGAGCATACTCCTGGTACCAGCATCAGCGATCACATGAAGACCCTGCAGCTCTGAAGTTTAGCTTCTACGAAGTGATCTCAGC
AGGGCCCCGTGCACCCTCGGAGCTCAGAGCCTTGCAGAAGAGATGTTTGGTCCCGGGGTGGTATGCCAGCCACATCGAGAGATGGCTTGT
TTATTTCCCCCCATTTCAGTTGCTAATTATTGATGGGCAACAACTAAGAACTGATCCTGCTACAGTGATGGATGAAGTACAGAAGTTTCT
AGGAGTCTTGCCTCATTATAATTACTCAGAAGCTTTAACGTTTGATTCTCATAAAGGTTTCTGGTGTCAGTTACTGGAAGAAGGTAAAAC
AAAATGCCTTGGAAAGAGCAAAGGAAGAAAATACCCTCCAATGGATTCTGATAGCAGGACATTTCTGTCAAGCTACTATCGAGATCACAA
CGTGGAACTCTCAAAGCTGCTGCACAAACTGGGTCAGCCTCTGCCATCCTGGCTGAGACAGGAGCTGCAGAAAGTAAGATAGCACTGAGA
GAAAACTTGAGACTTCATCGTCCATGTAGAACACACCTTTTCCAAAGCTTCCAGAAGCTACCAAAAGGCAGTTGAAAAATATACCTCTTC
AAATGAGAAAAAAGAACAGTTTCTTCCATGTGCTGGCACGTGGATGATTAGAAAAAAAGAAAAAGTATGTGTTACAAGCCTTGAGGCCTG
TGGCCTTTCTCTTAACCCATATCTGAGCCTGTGGGATTATTGTAGACTACTGTGCACTCATGTGGAAGTCAATTGCAACCAACATAAATA
TCAAACACAAATGCAGAACTGTTCCATTTCATAGTAATATTTACACTTTTATATATCAACTAAGATTGTGTCTCTGTAGGTTTTTAGACC
ACTGTTTGCCTGTACGATGTTTTCTTATTATTTTATTCTATAAAGTGTCCTATGAAACAAGAAGCAAAATAAACATCACAATGTAGCATA
AAATGTCAAAAGCATAACACCCATGAAAAATGCTTGCCAAAATTTAAATCCACTTAAGTATTTAGAAATAATTGTAAATTATAATTTGTG
CTAGATCAGAGTGGAAAAGTTATATATGAGTGTTATCTGCACCAAAAAAAAATAAGTGCTATAGCAAAAGTGATTTTTTCATATACATAG
TCTAGTGAATATATGTAAAAATTACTAACTCTTCCATCACAACGTAATTGTTATACTGAAATATATACTGTAAAGCTGTTGGATGGTAAA
TAGAAACACATCAAGTACACCAAAACAGTAAATAACAATGTAAAGTGTACTGACTGAATCCTCTAAAAGGGAGAAATTGTAGGGGTCTAA
AAACATATCATCGAGAATTCTATGTCCACTTGCTGTAAGCTGTGAATCTATCCCAGTAGTCCTCACTAGTTCTACAGAAATGCATGCCTA
GAGTCTGAGGTATGTGTCATCTCCAGAAACAGGTTGACTTTTAAATGTGAATAGCTATTTTTAATGCTCCCCAAAACAAAACCTATTAAA
CTAAAACTAAAAACAGTTTCCCTAGATGATGTGGTTAGGCTATTTACATTTAGGTTATTAAAAAATTGCATTTTCCCAGATAGTTCAAAA
TAAAATTATGTAATGTAGTAGAGATTTATAACAAAAAACAAATTAATATATTATTTGTAATCTAATGTTTGCAATGATACTTTTGATATA
AGGCAAAGAAACATAAGCAGAGCAGAGGCCCATTTTTGAAAATATTTCACCCATCACTCTGGTGGAAGTAACAGATCATAGGTACAATTA
AGGATTAGCTACTAAATTAAATGCAGGAAGTACAAAGATGAGCAAGTCATGCTCTTGAAATATATTTACATTTCAATTGTAAATAATATA
TATGGTTAATAAAGTTTCCAAAAAAGAAAAGAATACATCATACTTATTTTCCTGTTAATATTTACTTAATTTTTTTTTTTGAGAGGGGGA
CAGAGTCTCACTATGTCACCCAGGCTGGAGTGCAATGGTGTGATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCT
GCCTCAGCCTCCTGAGGAGCTGGGATTACAGCCATGCACCACCACGCCCGGGTAATTTTTGTATTTTTAGTAGTGACAGGGTTTCACCAT
GTTGACTAGGCTGATCTTGAACTCCTGACCTCATGATCCACCCACCTTGGCCTCTCAAAGTGCTGAGATTACAAGCGTGAGCCACCATGC
CCTGACTACTTAATTTTTAAATGTACTGTACATATACATAAAATTTAAGTAGTAAATTAATTCCCTGCTATGATTATAAGCCTTTATAAA
ATATTATCAAAGGTATGATTAGAAACAAATGGGAGGAAAACCCATAGTAAAAATATTTTCATTGTCATTTTAATGGGTAAAACTATCAAT
TACTAATTAGAAAATGAATTGTGAGATCCACTTACTATAAATTTTTAACTGTACATTATAATTACTTTTTTAAAGTTTCATGTACCTAAA
GCATATGCTAATTTTTAAATATACTATTAGCAGAAAAAATTGGAAAAATCACCAATTTTTAAGACTCTTGACTCTAAAAGCAAAATCAAA
GTGATTTGGACAAATATGGGAAACACAGTCTTCATGCTTACTGCTGTCTCTTTTATAGCAGCAGATGCCAGACATGCTAGGAAAATTACT
ATAGTCTTCCATCTCCACCAACTTAAGAAAACTGGCTTAGGAAGGTTAAACATGAGAATAGGCCTCAGCAGTTATATACAGTGTCATGTT
TTCATTTGGCAACAACATTTATTCTAATAAAAAAAGAAAAGAAAAACTGATACATTTATGCTTTAATGGTAAGATGTACATTTGAACTGC
TAAGCAAAGCTGCTAATGGCCTATTTTGTTTAGGTAAATCGAGTTGACTGAACACTTCATCCTTTTAAATAGATGTCAAAAACATACTCC
GTGTTTGTATAAAGACAGGAGAAAAAGGAAGAGATCTTACCAAAATTTATTCATTCACAAGTACATGTATTACGCTAGCTAGAGCAGCAA
ACCTGTGAAAGGATTTTTGACCACTCAATGTGTCTTGAAGACAGCATCAAATTCTAGAGGACATGCATACTTTCCACATTATATACTCCA
ACTGGTTAATATGCTAATCTGAAAGTAACATAAATACATATGAGAGAATAATGAGAGATAATCTGATTTAAAACTAGCTTTGTATAGAAT
TCCCTTTTTCATTGTTTAAAATATGAAACTTCCTCAGGAAGAAATGAAATGGTTATTTCAATGTTTATAGCTGTAATATTCTTGTCATTC
ACATTGAATGAAAATTACTGGAAACATTTTTTTCTCTGAGTTTTTTAAAATAAAAAACCTAGATATAATTCTGATAGTAGCATGGTACCT

>95601_95601_1_TXN-NDST3_TXN_chr9_113013100_ENST00000374517_NDST3_chr4_119059209_ENST00000296499_length(amino acids)=550AA_BP=85
MFGALDPFPSVLTAARQTPAAKMVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQEHGIP
TDMGYAVAPHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPKELDKSIQGG
ELFFTVVLNPISIFMTHLSNYGNDRLGLYTFVNLANFVKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCD
RLPKFLVIGPQKTGTTALYLFLVMHPSILSNSPSPKTFEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYFHSEEAPKRAAS
LVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFSFYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLLIIDGQQLR
TDPATVMDEVQKFLGVLPHYNYSEALTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRTFLSSYYRDHNVELSKLLHKLGQPLPS

--------------------------------------------------------------
>95601_95601_2_TXN-NDST3_TXN_chr9_113013100_ENST00000374517_NDST3_chr4_119059209_ENST00000433996_length(transcript)=1160nt_BP=394nt
CTCGCAGGCTCCAGGGGCGGGGCGTGGCCGGGGCGCAGCGACGGGCGCGGAGGTCCGGCCGGGCGCGCGCGCCCCCGCCACACGCACGCC
GGGCGTGCCAGTTTATAAAGGGAGAGAGCAAGCAGCGAGTCTTGAAGCTCTGTTTGGTGCTTTGGATCCATTTCCATCGGTCCTTACAGC
CGCTCGTCAGACTCCAGCAGCCAAGATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACT
TGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGT
GATATTCCTTGAAGTAGATGTGGATGACTGTCAGGAGCACGGCATTCCAACGGACATGGGCTACGCTGTGGCCCCTCACCATTCGGGCGT
CTACCCTGTACATGTTCAGCTTTATGAGGCCTGGAAGAAGGTCTGGAATATTAAAATCACCAGCACTGAAGAATATCCACATCTGAAGCC
AGCTAGATACCGGAGGGGTTTTATCCACAAAAACATCATGGTTCTCCCAAGACAAACCTGTGGGCTTTTCACTCACACCATTTTCTACAA
AGAATATCCAGGGGGTCCTAAAGAGCTGGATAAGAGTATCCAAGGAGGAGAACTTTTCTTCACTGTCGTCCTCAACCCTATCAGCATTTT
CATGACCCATTTGTCCAACTATGGGAATGACCGACTGGGATTATATACATTTGTTAATCTGGCCAACTTTGTGAAGAGCTGGACCAACCT
GCGACTTCAGACTCTGCCTCCAGTACAACTGGCCCACAAGTATTTTGAGCTGTTTCCTGATCAGAAAGACCCTCTCTGGCAGAATCCTTG
CGATGACAAACGCCACAGAGACATTTGGTCTAAAGAAAAAACTTGTGATCGCTTACCAAAATTCTTGGTAATAGGACCCCAGAAAACTGG
TACCACTGCTTTGTATTTGTTCCTGGTTATGCATCCTTCCATCCTTAGTAACTCCCCCAGCCCAAAAACCTTTGAGGAGGTATATGGATT

>95601_95601_2_TXN-NDST3_TXN_chr9_113013100_ENST00000374517_NDST3_chr4_119059209_ENST00000433996_length(amino acids)=319AA_BP=85
MFGALDPFPSVLTAARQTPAAKMVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQEHGIP
TDMGYAVAPHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPKELDKSIQGG
ELFFTVVLNPISIFMTHLSNYGNDRLGLYTFVNLANFVKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCD

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Fusion Gene PPI Analysis for TXN-NDST3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TXN-NDST3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TXN-NDST3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource