FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:TXNRD1-DACH2 (FusionGDB2 ID:95608)

Fusion Gene Summary for TXNRD1-DACH2

check button Fusion gene summary
Fusion gene informationFusion gene name: TXNRD1-DACH2
Fusion gene ID: 95608
HgeneTgene
Gene symbol

TXNRD1

DACH2

Gene ID

7296

117154

Gene namethioredoxin reductase 1dachshund family transcription factor 2
SynonymsGRIM-12|TR|TR1|TRXR1|TXNR-
Cytomap

12q23.3

Xq21.2

Type of geneprotein-codingprotein-coding
Descriptionthioredoxin reductase 1, cytoplasmicKM-102-derived reductase-like factorgene associated with retinoic and IFN-induced mortality 12 proteingene associated with retinoic and interferon-induced mortality 12 proteinoxidoreductasetestis tissue sperm-bindidachshund homolog 2
Modification date2020031320200313
UniProtAcc.

Q96NX9

Ensembl transtripts involved in fusion geneENST00000378070, ENST00000525566, 
ENST00000526691, ENST00000354940, 
ENST00000388854, ENST00000397736, 
ENST00000427956, ENST00000429002, 
ENST00000503506, ENST00000524698, 
ENST00000526006, ENST00000526390, 
ENST00000526950, ENST00000529546, 
ENST00000540716, ENST00000542918, 
ENST00000373125, ENST00000373131, 
ENST00000508860, ENST00000510272, 
Fusion gene scores* DoF score30 X 25 X 8=60003 X 3 X 2=18
# samples 373
** MAII scorelog2(37/6000*10)=-4.01936532486693
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TXNRD1 [Title/Abstract] AND DACH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTXNRD1(104744062)-DACH2(85631787), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TXNRD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DACH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW023803TXNRD1chr12

104744062

+DACH2chrX

85631787

+


Top

Fusion Gene ORF analysis for TXNRD1-DACH2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000378070ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000378070ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000378070ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000378070ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000525566ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000525566ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000525566ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000525566ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000526691ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000526691ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000526691ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
5CDS-intronENST00000526691ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000354940ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000354940ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000354940ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000354940ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000388854ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000388854ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000388854ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000388854ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000397736ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000397736ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000397736ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000397736ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000427956ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000427956ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000427956ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000427956ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000429002ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000429002ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000429002ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000429002ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000503506ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000503506ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000503506ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000503506ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000524698ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000524698ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000524698ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000524698ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526006ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526006ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526006ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526006ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526390ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526390ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526390ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526390ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526950ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526950ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526950ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000526950ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000529546ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000529546ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000529546ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000529546ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000540716ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000540716ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000540716ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000540716ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000542918ENST00000373125TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000542918ENST00000373131TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000542918ENST00000508860TXNRD1chr12

104744062

+DACH2chrX

85631787

+
intron-intronENST00000542918ENST00000510272TXNRD1chr12

104744062

+DACH2chrX

85631787

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for TXNRD1-DACH2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TXNRD1-DACH2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:104744062/:85631787)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DACH2

Q96NX9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for TXNRD1-DACH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for TXNRD1-DACH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for TXNRD1-DACH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for TXNRD1-DACH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource