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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TXNRD2-EVX1 (FusionGDB2 ID:95641)

Fusion Gene Summary for TXNRD2-EVX1

check button Fusion gene summary
Fusion gene informationFusion gene name: TXNRD2-EVX1
Fusion gene ID: 95641
HgeneTgene
Gene symbol

TXNRD2

EVX1

Gene ID

10587

2128

Gene namethioredoxin reductase 2even-skipped homeobox 1
SynonymsGCCD5|SELZ|TR|TR-BETA|TR3|TRXR2EVX-1
Cytomap

22q11.21

7p15.2

Type of geneprotein-codingprotein-coding
Descriptionthioredoxin reductase 2, mitochondrialselenoprotein Zthioredoxin reductase 3thioredoxin reductase TR3thioredoxin reductase betahomeobox even-skipped homolog protein 1eve, even-skipped homeo box homolog 1eve, even-skipped homeobox homolog 1even-skipped homeo box 1 (homolog of Drosophila)
Modification date2020031320200313
UniProtAcc.

P49640

Ensembl transtripts involved in fusion geneENST00000334363, ENST00000400518, 
ENST00000400519, ENST00000400521, 
ENST00000535882, ENST00000542719, 
ENST00000491939, 		ENST00000535619, 
ENST00000518886, ENST00000222761, 
ENST00000496902, 
Fusion gene scores* DoF score7 X 6 X 5=2103 X 2 X 1=6
# samples 73
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/6*10)=2.32192809488736
Context

PubMed: TXNRD2 [Title/Abstract] AND EVX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTXNRD2(19918553)-EVX1(27284667), # samples:3
Anticipated loss of major functional domain due to fusion event.TXNRD2-EVX1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TXNRD2-EVX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TXNRD2-EVX1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TXNRD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EVX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-HB-A3YV-01ATXNRD2chr22

19918553

-EVX1chr7

27284667

+
ChimerDB4SARCTCGA-X9-A971-01ATXNRD2chr22

19918553

-EVX1chr7

27284667

+


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Fusion Gene ORF analysis for TXNRD2-EVX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334363ENST00000535619TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-5UTRENST00000400518ENST00000535619TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-5UTRENST00000400519ENST00000535619TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-5UTRENST00000400521ENST00000535619TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-5UTRENST00000535882ENST00000535619TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-5UTRENST00000542719ENST00000535619TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-intronENST00000334363ENST00000518886TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-intronENST00000400518ENST00000518886TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-intronENST00000400519ENST00000518886TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-intronENST00000400521ENST00000518886TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-intronENST00000535882ENST00000518886TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5CDS-intronENST00000542719ENST00000518886TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5UTR-3CDSENST00000491939ENST00000222761TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5UTR-3CDSENST00000491939ENST00000496902TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5UTR-5UTRENST00000491939ENST00000535619TXNRD2chr22

19918553

-EVX1chr7

27284667

+
5UTR-intronENST00000491939ENST00000518886TXNRD2chr22

19918553

-EVX1chr7

27284667

+
Frame-shiftENST00000400518ENST00000222761TXNRD2chr22

19918553

-EVX1chr7

27284667

+
Frame-shiftENST00000400518ENST00000496902TXNRD2chr22

19918553

-EVX1chr7

27284667

+
Frame-shiftENST00000400521ENST00000222761TXNRD2chr22

19918553

-EVX1chr7

27284667

+
Frame-shiftENST00000400521ENST00000496902TXNRD2chr22

19918553

-EVX1chr7

27284667

+
Frame-shiftENST00000542719ENST00000222761TXNRD2chr22

19918553

-EVX1chr7

27284667

+
Frame-shiftENST00000542719ENST00000496902TXNRD2chr22

19918553

-EVX1chr7

27284667

+
In-frameENST00000334363ENST00000222761TXNRD2chr22

19918553

-EVX1chr7

27284667

+
In-frameENST00000334363ENST00000496902TXNRD2chr22

19918553

-EVX1chr7

27284667

+
In-frameENST00000400519ENST00000222761TXNRD2chr22

19918553

-EVX1chr7

27284667

+
In-frameENST00000400519ENST00000496902TXNRD2chr22

19918553

-EVX1chr7

27284667

+
In-frameENST00000535882ENST00000222761TXNRD2chr22

19918553

-EVX1chr7

27284667

+
In-frameENST00000535882ENST00000496902TXNRD2chr22

19918553

-EVX1chr7

27284667

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400519TXNRD2chr2219918553-ENST00000496902EVX1chr727284667+19681690965321
ENST00000400519TXNRD2chr2219918553-ENST00000222761EVX1chr727284667+9661690965321
ENST00000535882TXNRD2chr2219918553-ENST00000496902EVX1chr727284667+19681690965321
ENST00000535882TXNRD2chr2219918553-ENST00000222761EVX1chr727284667+9661690965321
ENST00000334363TXNRD2chr2219918553-ENST00000496902EVX1chr727284667+19721731969322
ENST00000334363TXNRD2chr2219918553-ENST00000222761EVX1chr727284667+9701731969323

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400519ENST00000496902TXNRD2chr2219918553-EVX1chr727284667+0.36576780.6342322
ENST00000400519ENST00000222761TXNRD2chr2219918553-EVX1chr727284667+0.41027960.58972037
ENST00000535882ENST00000496902TXNRD2chr2219918553-EVX1chr727284667+0.36576780.6342322
ENST00000535882ENST00000222761TXNRD2chr2219918553-EVX1chr727284667+0.41027960.58972037
ENST00000334363ENST00000496902TXNRD2chr2219918553-EVX1chr727284667+0.315558730.68444127
ENST00000334363ENST00000222761TXNRD2chr2219918553-EVX1chr727284667+0.324663460.67533654

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Fusion Genomic Features for TXNRD2-EVX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TXNRD2chr2219918552-EVX1chr727284666+0.0116197180.9883803
TXNRD2chr2219918552-EVX1chr727284666+0.0116197180.9883803
TXNRD2chr2219918552-EVX1chr727284666+0.0116197180.9883803
TXNRD2chr2219918552-EVX1chr727284666+0.0116197180.9883803

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TXNRD2-EVX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:19918553/chr7:27284667)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EVX1

P49640

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play a role in the specification of neuronal cell types.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEVX1chr22:19918553chr7:27284667ENST0000049690203289_297142408.0Compositional biasNote=Ala-rich
TgeneEVX1chr22:19918553chr7:27284667ENST0000049690203361_368142408.0Compositional biasNote=Ala-rich
TgeneEVX1chr22:19918553chr7:27284667ENST0000049690203183_242142408.0DNA bindingHomeobox

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTXNRD2chr22:19918553chr7:27284667ENST00000400521-21841_7057625.6666666666666Nucleotide bindingFAD
TgeneEVX1chr22:19918553chr7:27284667ENST0000049690203114_124142408.0Compositional biasNote=Asp/Glu-rich (acidic)


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Fusion Gene Sequence for TXNRD2-EVX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95641_95641_1_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000334363_EVX1_chr7_27284667_ENST00000222761_length(transcript)=970nt_BP=173nt
GATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAGGCCGTGGCGGGCGGGGTGCGGGGCGCGGC
GCGGGGCGCAGCAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGGGTCCGG
CTCCGAGGCGCTGGTCGGCAGTCCGAACGGAGGGAGCGAGACCCCCAAGAGCAACGGCGGCAGTGGTGGGGGCGGCTCGCAAGGCACCCT
GGCGTGCAGCGCCAGTGACCAGATGCGTCGTTACCGCACCGCCTTCACCCGAGAGCAGATTGCGCGGCTGGAGAAGGAATTCTACCGGGA
GAACTACGTATCCAGGCCGCGGAGATGTGAGCTGGCGGCCGCCCTAAACCTGCCGGAAACCACCATCAAGGTGTGGTTCCAGAACCGGCG
CATGAAGGACAAGCGGCAGCGCCTGGCCATGACGTGGCCGCACCCGGCGGACCCCGCCTTCTACACTTACATGATGAGCCATGCGGCGGC
CGCGGGCGGCCTGCCCTACCCCTTCCCATCGCACCTGCCCCTGCCCTACTACTCGCCGGTGGGCCTGGGCGCCGCATCCGCCGCCTCCGC
CGCCGCCTCGCCCTTCAGCGGCTCGCTGCGCCCGCTCGACACGTTCCGCGTGCTGTCGCAGCCCTACCCGCGGCCCGAACTGCTGTGCGC
CTTCCGCCACCCGCCGCTCTACCCCGGGCCCGCGCACGGACTGGGCGCCTCTGCCGGCGGCCCCTGCTCCTGCCTCGCCTGTCACAGCGG
CCCGGCCAACGGGCTGGCGCCCCGGGCTGCCGCCGCCTCGGACTTCACCTGTGCCTCCACCTCCCGCTCGGACTCCTTCCTCACCTTCGC

>95641_95641_1_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000334363_EVX1_chr7_27284667_ENST00000222761_length(amino acids)=323AA_BP=57
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEGSGSEALVGSPNGGSETPKSNGGSGGGGSQGTL
ACSASDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAA
AGGLPYPFPSHLPLPYYSPVGLGAASAASAAASPFSGSLRPLDTFRVLSQPYPRPELLCAFRHPPLYPGPAHGLGASAGGPCSCLACHSG

--------------------------------------------------------------
>95641_95641_2_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000334363_EVX1_chr7_27284667_ENST00000496902_length(transcript)=1972nt_BP=173nt
GATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAGGCCGTGGCGGGCGGGGTGCGGGGCGCGGC
GCGGGGCGCAGCAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGGGTCCGG
CTCCGAGGCGCTGGTCGGCAGTCCGAACGGAGGGAGCGAGACCCCCAAGAGCAACGGCGGCAGTGGTGGGGGCGGCTCGCAAGGCACCCT
GGCGTGCAGCGCCAGTGACCAGATGCGTCGTTACCGCACCGCCTTCACCCGAGAGCAGATTGCGCGGCTGGAGAAGGAATTCTACCGGGA
GAACTACGTATCCAGGCCGCGGAGATGTGAGCTGGCGGCCGCCCTAAACCTGCCGGAAACCACCATCAAGGTGTGGTTCCAGAACCGGCG
CATGAAGGACAAGCGGCAGCGCCTGGCCATGACGTGGCCGCACCCGGCGGACCCCGCCTTCTACACTTACATGATGAGCCATGCGGCGGC
CGCGGGCGGCCTGCCCTACCCCTTCCCATCGCACCTGCCCCTGCCCTACTACTCGCCGGTGGGCCTGGGCGCCGCATCCGCCGCCTCCGC
CGCCGCCTCGCCCTTCAGCGGCTCGCTGCGCCCGCTCGACACGTTCCGCGTGCTGTCGCAGCCCTACCCGCGGCCCGAACTGCTGTGCGC
CTTCCGCCACCCGCCGCTCTACCCCGGGCCCGCGCACGGACTGGGCGCCTCTGCCGGCGGCCCCTGCTCCTGCCTCGCCTGTCACAGCGG
CCCGGCCAACGGGCTGGCGCCCCGGGCTGCCGCCGCCTCGGACTTCACCTGTGCCTCCACCTCCCGCTCGGACTCCTTCCTCACCTTCGC
GCCCTCGGTGCTCAGCAAGGCCTCCTCCGTCGCGCTGGACCAGAGGGAGGAGGTGCCCCTCACTAGATAAGGGGCCGCCGGCTGGCTGCC
GGCTCCATGACGCCCGTGGGGTCACCCCCCGGCCCCGGGACTCAGCCAGCCTCGCTCCTCGCTCCTCGCTCCTCGCCCCTAGGACGCCAA
GGGGGAAAGGAGAGGGCGGAAAAGGACCAGCGGGATCCGGCCGCAAGAATTGGAAAGCCTAGGAAGTGGCGGTGGCTGGCGCGTTTGGGG
AGCAGGAGTGGGGATAGGGAAGCAGAGCTTGAGAGACCTTCCTCCGGGGCAGCCTCCGGACCCACCGCCCCCCACCAGGGTCGAGGCTGT
AGCTCCAAAGCTAAACAAAACTTAGCAGCAACAGCAACCAATATCCAGTCCCTCGGCCCCTCGGCCCCTCACCCTCCACCTCACACTCCC
TTCTCACCGGGCCCCCTCTCCCCAGCCAAGGCCCAAGCACTGGAAAGGGAAATTGCTGTCTCTCTGAACAAAATGCTGTGTATGCAGAGC
AGGTAGAGATTAATCTTTGCCAGCTTTTCCAAGGCATGACAAGGGGCTGGTGGATGGCAACATACCAGTCATTTGGAGGAGAGAGTGAGA
GATGATTTACTACCAGGGAGAATCCAGCCCCTTGGCATGGGACCTGGAGCCTCGACTACACAGCATCTTCTGGGTCTGGCGTCTGCCAGC
ACCTGATCTCTTTCCTCATTCCCAGCTTTGTGACACTTCTCAACTTGCGGCTCCATCTCTCCCTGCCCCCACTTTTTTGTTGGCCAGGGA
GGCTGCAGATGCCCCAGGAGCCCTTTGCCGCTTCTATGAGGCCAAGCCTTTTTTCCCTGGGCCCAGCACACACCCTGATTAGCAAGTGAT
GTGTGCGAGGAGGGTTTGTGAATGTTGAATGTGTAATAATGATCACCATGGAGCTGGCCACTGACCCCAGAGCTGAGCTGTTAACAAGGC

>95641_95641_2_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000334363_EVX1_chr7_27284667_ENST00000496902_length(amino acids)=322AA_BP=57
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEGSGSEALVGSPNGGSETPKSNGGSGGGGSQGTL
ACSASDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAA
AGGLPYPFPSHLPLPYYSPVGLGAASAASAAASPFSGSLRPLDTFRVLSQPYPRPELLCAFRHPPLYPGPAHGLGASAGGPCSCLACHSG

--------------------------------------------------------------
>95641_95641_3_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000400519_EVX1_chr7_27284667_ENST00000222761_length(transcript)=966nt_BP=169nt
ATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAGGCCGTGGCGGGCGGGGTGCGGGGCGCGGCG
CGGGGCGCAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGGGTCCGGCTCC
GAGGCGCTGGTCGGCAGTCCGAACGGAGGGAGCGAGACCCCCAAGAGCAACGGCGGCAGTGGTGGGGGCGGCTCGCAAGGCACCCTGGCG
TGCAGCGCCAGTGACCAGATGCGTCGTTACCGCACCGCCTTCACCCGAGAGCAGATTGCGCGGCTGGAGAAGGAATTCTACCGGGAGAAC
TACGTATCCAGGCCGCGGAGATGTGAGCTGGCGGCCGCCCTAAACCTGCCGGAAACCACCATCAAGGTGTGGTTCCAGAACCGGCGCATG
AAGGACAAGCGGCAGCGCCTGGCCATGACGTGGCCGCACCCGGCGGACCCCGCCTTCTACACTTACATGATGAGCCATGCGGCGGCCGCG
GGCGGCCTGCCCTACCCCTTCCCATCGCACCTGCCCCTGCCCTACTACTCGCCGGTGGGCCTGGGCGCCGCATCCGCCGCCTCCGCCGCC
GCCTCGCCCTTCAGCGGCTCGCTGCGCCCGCTCGACACGTTCCGCGTGCTGTCGCAGCCCTACCCGCGGCCCGAACTGCTGTGCGCCTTC
CGCCACCCGCCGCTCTACCCCGGGCCCGCGCACGGACTGGGCGCCTCTGCCGGCGGCCCCTGCTCCTGCCTCGCCTGTCACAGCGGCCCG
GCCAACGGGCTGGCGCCCCGGGCTGCCGCCGCCTCGGACTTCACCTGTGCCTCCACCTCCCGCTCGGACTCCTTCCTCACCTTCGCGCCC

>95641_95641_3_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000400519_EVX1_chr7_27284667_ENST00000222761_length(amino acids)=321AA_BP=56
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAGQRDYDLLVVGGGSGGLACAKEGSGSEALVGSPNGGSETPKSNGGSGGGGSQGTLA
CSASDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAAA
GGLPYPFPSHLPLPYYSPVGLGAASAASAAASPFSGSLRPLDTFRVLSQPYPRPELLCAFRHPPLYPGPAHGLGASAGGPCSCLACHSGP

--------------------------------------------------------------
>95641_95641_4_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000400519_EVX1_chr7_27284667_ENST00000496902_length(transcript)=1968nt_BP=169nt
ATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAGGCCGTGGCGGGCGGGGTGCGGGGCGCGGCG
CGGGGCGCAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGGGTCCGGCTCC
GAGGCGCTGGTCGGCAGTCCGAACGGAGGGAGCGAGACCCCCAAGAGCAACGGCGGCAGTGGTGGGGGCGGCTCGCAAGGCACCCTGGCG
TGCAGCGCCAGTGACCAGATGCGTCGTTACCGCACCGCCTTCACCCGAGAGCAGATTGCGCGGCTGGAGAAGGAATTCTACCGGGAGAAC
TACGTATCCAGGCCGCGGAGATGTGAGCTGGCGGCCGCCCTAAACCTGCCGGAAACCACCATCAAGGTGTGGTTCCAGAACCGGCGCATG
AAGGACAAGCGGCAGCGCCTGGCCATGACGTGGCCGCACCCGGCGGACCCCGCCTTCTACACTTACATGATGAGCCATGCGGCGGCCGCG
GGCGGCCTGCCCTACCCCTTCCCATCGCACCTGCCCCTGCCCTACTACTCGCCGGTGGGCCTGGGCGCCGCATCCGCCGCCTCCGCCGCC
GCCTCGCCCTTCAGCGGCTCGCTGCGCCCGCTCGACACGTTCCGCGTGCTGTCGCAGCCCTACCCGCGGCCCGAACTGCTGTGCGCCTTC
CGCCACCCGCCGCTCTACCCCGGGCCCGCGCACGGACTGGGCGCCTCTGCCGGCGGCCCCTGCTCCTGCCTCGCCTGTCACAGCGGCCCG
GCCAACGGGCTGGCGCCCCGGGCTGCCGCCGCCTCGGACTTCACCTGTGCCTCCACCTCCCGCTCGGACTCCTTCCTCACCTTCGCGCCC
TCGGTGCTCAGCAAGGCCTCCTCCGTCGCGCTGGACCAGAGGGAGGAGGTGCCCCTCACTAGATAAGGGGCCGCCGGCTGGCTGCCGGCT
CCATGACGCCCGTGGGGTCACCCCCCGGCCCCGGGACTCAGCCAGCCTCGCTCCTCGCTCCTCGCTCCTCGCCCCTAGGACGCCAAGGGG
GAAAGGAGAGGGCGGAAAAGGACCAGCGGGATCCGGCCGCAAGAATTGGAAAGCCTAGGAAGTGGCGGTGGCTGGCGCGTTTGGGGAGCA
GGAGTGGGGATAGGGAAGCAGAGCTTGAGAGACCTTCCTCCGGGGCAGCCTCCGGACCCACCGCCCCCCACCAGGGTCGAGGCTGTAGCT
CCAAAGCTAAACAAAACTTAGCAGCAACAGCAACCAATATCCAGTCCCTCGGCCCCTCGGCCCCTCACCCTCCACCTCACACTCCCTTCT
CACCGGGCCCCCTCTCCCCAGCCAAGGCCCAAGCACTGGAAAGGGAAATTGCTGTCTCTCTGAACAAAATGCTGTGTATGCAGAGCAGGT
AGAGATTAATCTTTGCCAGCTTTTCCAAGGCATGACAAGGGGCTGGTGGATGGCAACATACCAGTCATTTGGAGGAGAGAGTGAGAGATG
ATTTACTACCAGGGAGAATCCAGCCCCTTGGCATGGGACCTGGAGCCTCGACTACACAGCATCTTCTGGGTCTGGCGTCTGCCAGCACCT
GATCTCTTTCCTCATTCCCAGCTTTGTGACACTTCTCAACTTGCGGCTCCATCTCTCCCTGCCCCCACTTTTTTGTTGGCCAGGGAGGCT
GCAGATGCCCCAGGAGCCCTTTGCCGCTTCTATGAGGCCAAGCCTTTTTTCCCTGGGCCCAGCACACACCCTGATTAGCAAGTGATGTGT
GCGAGGAGGGTTTGTGAATGTTGAATGTGTAATAATGATCACCATGGAGCTGGCCACTGACCCCAGAGCTGAGCTGTTAACAAGGCGCCC

>95641_95641_4_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000400519_EVX1_chr7_27284667_ENST00000496902_length(amino acids)=321AA_BP=56
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAGQRDYDLLVVGGGSGGLACAKEGSGSEALVGSPNGGSETPKSNGGSGGGGSQGTLA
CSASDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAAA
GGLPYPFPSHLPLPYYSPVGLGAASAASAAASPFSGSLRPLDTFRVLSQPYPRPELLCAFRHPPLYPGPAHGLGASAGGPCSCLACHSGP

--------------------------------------------------------------
>95641_95641_5_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000535882_EVX1_chr7_27284667_ENST00000222761_length(transcript)=966nt_BP=169nt
ATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAGGCCGTGGCGGGCGGGGTGCGGGGCGCGGCG
CGGGGCGCAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGGGTCCGGCTCC
GAGGCGCTGGTCGGCAGTCCGAACGGAGGGAGCGAGACCCCCAAGAGCAACGGCGGCAGTGGTGGGGGCGGCTCGCAAGGCACCCTGGCG
TGCAGCGCCAGTGACCAGATGCGTCGTTACCGCACCGCCTTCACCCGAGAGCAGATTGCGCGGCTGGAGAAGGAATTCTACCGGGAGAAC
TACGTATCCAGGCCGCGGAGATGTGAGCTGGCGGCCGCCCTAAACCTGCCGGAAACCACCATCAAGGTGTGGTTCCAGAACCGGCGCATG
AAGGACAAGCGGCAGCGCCTGGCCATGACGTGGCCGCACCCGGCGGACCCCGCCTTCTACACTTACATGATGAGCCATGCGGCGGCCGCG
GGCGGCCTGCCCTACCCCTTCCCATCGCACCTGCCCCTGCCCTACTACTCGCCGGTGGGCCTGGGCGCCGCATCCGCCGCCTCCGCCGCC
GCCTCGCCCTTCAGCGGCTCGCTGCGCCCGCTCGACACGTTCCGCGTGCTGTCGCAGCCCTACCCGCGGCCCGAACTGCTGTGCGCCTTC
CGCCACCCGCCGCTCTACCCCGGGCCCGCGCACGGACTGGGCGCCTCTGCCGGCGGCCCCTGCTCCTGCCTCGCCTGTCACAGCGGCCCG
GCCAACGGGCTGGCGCCCCGGGCTGCCGCCGCCTCGGACTTCACCTGTGCCTCCACCTCCCGCTCGGACTCCTTCCTCACCTTCGCGCCC

>95641_95641_5_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000535882_EVX1_chr7_27284667_ENST00000222761_length(amino acids)=321AA_BP=56
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAGQRDYDLLVVGGGSGGLACAKEGSGSEALVGSPNGGSETPKSNGGSGGGGSQGTLA
CSASDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAAA
GGLPYPFPSHLPLPYYSPVGLGAASAASAAASPFSGSLRPLDTFRVLSQPYPRPELLCAFRHPPLYPGPAHGLGASAGGPCSCLACHSGP

--------------------------------------------------------------
>95641_95641_6_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000535882_EVX1_chr7_27284667_ENST00000496902_length(transcript)=1968nt_BP=169nt
ATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAGGCCGTGGCGGGCGGGGTGCGGGGCGCGGCG
CGGGGCGCAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGGGTCCGGCTCC
GAGGCGCTGGTCGGCAGTCCGAACGGAGGGAGCGAGACCCCCAAGAGCAACGGCGGCAGTGGTGGGGGCGGCTCGCAAGGCACCCTGGCG
TGCAGCGCCAGTGACCAGATGCGTCGTTACCGCACCGCCTTCACCCGAGAGCAGATTGCGCGGCTGGAGAAGGAATTCTACCGGGAGAAC
TACGTATCCAGGCCGCGGAGATGTGAGCTGGCGGCCGCCCTAAACCTGCCGGAAACCACCATCAAGGTGTGGTTCCAGAACCGGCGCATG
AAGGACAAGCGGCAGCGCCTGGCCATGACGTGGCCGCACCCGGCGGACCCCGCCTTCTACACTTACATGATGAGCCATGCGGCGGCCGCG
GGCGGCCTGCCCTACCCCTTCCCATCGCACCTGCCCCTGCCCTACTACTCGCCGGTGGGCCTGGGCGCCGCATCCGCCGCCTCCGCCGCC
GCCTCGCCCTTCAGCGGCTCGCTGCGCCCGCTCGACACGTTCCGCGTGCTGTCGCAGCCCTACCCGCGGCCCGAACTGCTGTGCGCCTTC
CGCCACCCGCCGCTCTACCCCGGGCCCGCGCACGGACTGGGCGCCTCTGCCGGCGGCCCCTGCTCCTGCCTCGCCTGTCACAGCGGCCCG
GCCAACGGGCTGGCGCCCCGGGCTGCCGCCGCCTCGGACTTCACCTGTGCCTCCACCTCCCGCTCGGACTCCTTCCTCACCTTCGCGCCC
TCGGTGCTCAGCAAGGCCTCCTCCGTCGCGCTGGACCAGAGGGAGGAGGTGCCCCTCACTAGATAAGGGGCCGCCGGCTGGCTGCCGGCT
CCATGACGCCCGTGGGGTCACCCCCCGGCCCCGGGACTCAGCCAGCCTCGCTCCTCGCTCCTCGCTCCTCGCCCCTAGGACGCCAAGGGG
GAAAGGAGAGGGCGGAAAAGGACCAGCGGGATCCGGCCGCAAGAATTGGAAAGCCTAGGAAGTGGCGGTGGCTGGCGCGTTTGGGGAGCA
GGAGTGGGGATAGGGAAGCAGAGCTTGAGAGACCTTCCTCCGGGGCAGCCTCCGGACCCACCGCCCCCCACCAGGGTCGAGGCTGTAGCT
CCAAAGCTAAACAAAACTTAGCAGCAACAGCAACCAATATCCAGTCCCTCGGCCCCTCGGCCCCTCACCCTCCACCTCACACTCCCTTCT
CACCGGGCCCCCTCTCCCCAGCCAAGGCCCAAGCACTGGAAAGGGAAATTGCTGTCTCTCTGAACAAAATGCTGTGTATGCAGAGCAGGT
AGAGATTAATCTTTGCCAGCTTTTCCAAGGCATGACAAGGGGCTGGTGGATGGCAACATACCAGTCATTTGGAGGAGAGAGTGAGAGATG
ATTTACTACCAGGGAGAATCCAGCCCCTTGGCATGGGACCTGGAGCCTCGACTACACAGCATCTTCTGGGTCTGGCGTCTGCCAGCACCT
GATCTCTTTCCTCATTCCCAGCTTTGTGACACTTCTCAACTTGCGGCTCCATCTCTCCCTGCCCCCACTTTTTTGTTGGCCAGGGAGGCT
GCAGATGCCCCAGGAGCCCTTTGCCGCTTCTATGAGGCCAAGCCTTTTTTCCCTGGGCCCAGCACACACCCTGATTAGCAAGTGATGTGT
GCGAGGAGGGTTTGTGAATGTTGAATGTGTAATAATGATCACCATGGAGCTGGCCACTGACCCCAGAGCTGAGCTGTTAACAAGGCGCCC

>95641_95641_6_TXNRD2-EVX1_TXNRD2_chr22_19918553_ENST00000535882_EVX1_chr7_27284667_ENST00000496902_length(amino acids)=321AA_BP=56
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAGQRDYDLLVVGGGSGGLACAKEGSGSEALVGSPNGGSETPKSNGGSGGGGSQGTLA
CSASDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWPHPADPAFYTYMMSHAAAA
GGLPYPFPSHLPLPYYSPVGLGAASAASAAASPFSGSLRPLDTFRVLSQPYPRPELLCAFRHPPLYPGPAHGLGASAGGPCSCLACHSGP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TXNRD2-EVX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TXNRD2-EVX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TXNRD2-EVX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource