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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TXNRD2-USP14 (FusionGDB2 ID:95647)

Fusion Gene Summary for TXNRD2-USP14

check button Fusion gene summary
Fusion gene informationFusion gene name: TXNRD2-USP14
Fusion gene ID: 95647
HgeneTgene
Gene symbol

TXNRD2

USP14

Gene ID

10587

9097

Gene namethioredoxin reductase 2ubiquitin specific peptidase 14
SynonymsGCCD5|SELZ|TR|TR-BETA|TR3|TRXR2TGT
Cytomap

22q11.21

18p11.32

Type of geneprotein-codingprotein-coding
Descriptionthioredoxin reductase 2, mitochondrialselenoprotein Zthioredoxin reductase 3thioredoxin reductase TR3thioredoxin reductase betaubiquitin carboxyl-terminal hydrolase 14deubiquitinating enzyme 14tRNA-guanine transglycosylase, 60-kD subunitubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)ubiquitin specific protease 14 (tRNA-guanine transglycosylase)ubiquitin thioe
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000491939, ENST00000334363, 
ENST00000400519, ENST00000535882, 
ENST00000400518, ENST00000400521, 
ENST00000542719, 		ENST00000261601, 
ENST00000383589, ENST00000400266, 
ENST00000582707, 
Fusion gene scores* DoF score7 X 6 X 5=2107 X 7 X 4=196
# samples 77
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TXNRD2 [Title/Abstract] AND USP14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTXNRD2(19882930)-USP14(202880), # samples:1
Anticipated loss of major functional domain due to fusion event.TXNRD2-USP14 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TXNRD2-USP14 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TXNRD2-USP14 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TXNRD2-USP14 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSP14

GO:0016579

protein deubiquitination

23958854


check buttonFusion gene breakpoints across TXNRD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USP14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0129-01ATXNRD2chr22

19882930

-USP14chr18

202880

+


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Fusion Gene ORF analysis for TXNRD2-USP14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000491939ENST00000261601TXNRD2chr22

19882930

-USP14chr18

202880

+
5UTR-3CDSENST00000491939ENST00000383589TXNRD2chr22

19882930

-USP14chr18

202880

+
5UTR-3CDSENST00000491939ENST00000400266TXNRD2chr22

19882930

-USP14chr18

202880

+
5UTR-3CDSENST00000491939ENST00000582707TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000334363ENST00000261601TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000334363ENST00000383589TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000334363ENST00000400266TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000334363ENST00000582707TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000400519ENST00000261601TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000400519ENST00000383589TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000400519ENST00000400266TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000400519ENST00000582707TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000535882ENST00000261601TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000535882ENST00000383589TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000535882ENST00000400266TXNRD2chr22

19882930

-USP14chr18

202880

+
Frame-shiftENST00000535882ENST00000582707TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000400518ENST00000261601TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000400518ENST00000383589TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000400518ENST00000400266TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000400518ENST00000582707TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000400521ENST00000261601TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000400521ENST00000383589TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000400521ENST00000400266TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000400521ENST00000582707TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000542719ENST00000261601TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000542719ENST00000383589TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000542719ENST00000400266TXNRD2chr22

19882930

-USP14chr18

202880

+
In-frameENST00000542719ENST00000582707TXNRD2chr22

19882930

-USP14chr18

202880

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400521TXNRD2chr2219882930-ENST00000582707USP14chr18202880+167295671080357
ENST00000400521TXNRD2chr2219882930-ENST00000400266USP14chr18202880+163195671080357
ENST00000400521TXNRD2chr2219882930-ENST00000383589USP14chr18202880+227895671080357
ENST00000400521TXNRD2chr2219882930-ENST00000261601USP14chr18202880+491095671080357
ENST00000400518TXNRD2chr2219882930-ENST00000582707USP14chr18202880+175910431841167327
ENST00000400518TXNRD2chr2219882930-ENST00000400266USP14chr18202880+171810431841167327
ENST00000400518TXNRD2chr2219882930-ENST00000383589USP14chr18202880+236510431841167327
ENST00000400518TXNRD2chr2219882930-ENST00000261601USP14chr18202880+499710431841167327
ENST00000542719TXNRD2chr2219882930-ENST00000582707USP14chr18202880+1634918591042327
ENST00000542719TXNRD2chr2219882930-ENST00000400266USP14chr18202880+1593918591042327
ENST00000542719TXNRD2chr2219882930-ENST00000383589USP14chr18202880+2240918591042327
ENST00000542719TXNRD2chr2219882930-ENST00000261601USP14chr18202880+4872918591042327

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400521ENST00000582707TXNRD2chr2219882930-USP14chr18202880+0.0030778970.9969221
ENST00000400521ENST00000400266TXNRD2chr2219882930-USP14chr18202880+0.0035708790.99642915
ENST00000400521ENST00000383589TXNRD2chr2219882930-USP14chr18202880+0.0013399340.9986601
ENST00000400521ENST00000261601TXNRD2chr2219882930-USP14chr18202880+0.000501640.99949837
ENST00000400518ENST00000582707TXNRD2chr2219882930-USP14chr18202880+0.0032429810.996757
ENST00000400518ENST00000400266TXNRD2chr2219882930-USP14chr18202880+0.0034476930.99655235
ENST00000400518ENST00000383589TXNRD2chr2219882930-USP14chr18202880+0.0014333270.9985667
ENST00000400518ENST00000261601TXNRD2chr2219882930-USP14chr18202880+0.0004033220.99959666
ENST00000542719ENST00000582707TXNRD2chr2219882930-USP14chr18202880+0.0026770.997323
ENST00000542719ENST00000400266TXNRD2chr2219882930-USP14chr18202880+0.0031232180.9968767
ENST00000542719ENST00000383589TXNRD2chr2219882930-USP14chr18202880+0.0011422680.99885774
ENST00000542719ENST00000261601TXNRD2chr2219882930-USP14chr18202880+0.0003802960.9996197

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Fusion Genomic Features for TXNRD2-USP14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TXNRD2chr2219882929-USP14chr18202879+0.0412485970.95875144
TXNRD2chr2219882929-USP14chr18202879+0.0412485970.95875144

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TXNRD2-USP14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:19882930/chr18:202880)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTXNRD2chr22:19882930chr18:202880ENST00000400521-111841_70316625.6666666666666Nucleotide bindingFAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUSP14chr22:19882930chr18:202880ENST00000261601916105_483292495.0DomainNote=USP
TgeneUSP14chr22:19882930chr18:202880ENST000002616019164_80292495.0DomainUbiquitin-like
TgeneUSP14chr22:19882930chr18:202880ENST00000582707815105_483257460.0DomainNote=USP
TgeneUSP14chr22:19882930chr18:202880ENST000005827078154_80257460.0DomainUbiquitin-like


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Fusion Gene Sequence for TXNRD2-USP14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95647_95647_1_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400518_USP14_chr18_202880_ENST00000261601_length(transcript)=4997nt_BP=1043nt
CCGGACCTCAGGCCCAGTTCAGTGTACTTCCCCTCTCTACTTCCTCCCTCCAGTCCCTTCTCCATCCCTCCCTTTTTTGGCTGCCCCTTG
CCTGCCTTCCTCGCCAGTAGCTTGCAGAGTAGACACGATGACACCTTTTGCAGGCTAAAAAGGCTGAGAGTGGCACTATGTGCAGTGAGC
CACCATGGAGGACCAAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGC
CCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGT
GGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCA
GCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGA
CAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCT
GTCAGCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGA
TGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGG
GATTGGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGC
ATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAG
CACCACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAACGT
TGCAAAGAAATGCCTTGTATATCAAATCTTCCAAGATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATAAAG
AGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGATGTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTCAAG
AGAAAATGGTGTCTTTTCGATCCAAATTCAAGGATCTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTAGTC
CCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTTGCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTACTAA
CACACCAGGGAAGGTCTAGTTCTTCAGGTCATTATGTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACAAAG
TCAGCATCGTAACACCAGAAGATATCTTACGGCTTTCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCAGAG
TTGAAATAATGGAAGAGGAAAGTGAACAGTAATCTTCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCATTTC
TATAATCCAGAGCTTTAGAGGAAGACACATAGGTGGGTTTATGTTTCACCTCATTTGGAACAAAAGAGGACAGAAGCAGACCACTCTGTG
CACCAACCTAAAAAATTACAGAGAAGAGAAAATTATCTTTGGATTGTGCTGCCCTATATAAAGGTGGCAGAAAGACATTTTTAAAAAGCT
TATTATTTCTTGCATTATTTTAAAAAGTTCAGAGTTGAAATGCCTTTCAACCATTTCCTTCTGTGGTCATTTTTCTTGCTGCCTTTTTCA
CCCAAGATTCAGCAGTCAGATGTTTACTGCACACCTATTACCTATTATTTGCTGTTCTTGCATGGTTCAAACCACCATTCTGTAGCCACC
CATCCTTTGCCTTATCTAACAAACATTTTTCCAGGAAGGTGGAAAAGGAAGTGTTGCTCTCATTGTGTGACTCAGTGCTGCTGTCCATCC
CATGGAAACATGGGCACAATCAAGTATTTGTCCAGCCTATTGCAGGCTTTTCCTGACTTTAAAATAAATTGTGATCAATAATAGTACCTT
TGATTATACATTTATTATTGTGTCTCTCTCTGATGTACTGTGGATTGTACATTTAACTTTGGAATGGCTTTGTAATAATCAGTCTTAAGA
AAATGTTGACAAGCTCTGGTTGCTTATTTTTAGAAAATGAGGACATTTAATAATAATAAAAAAAAAGGGATTAATAGCTTTTGACCTCAA
GTCTTTTGTCTTCTGAGTGTTGGAGCTTGGCTGAAGACATGTTTAATACTGTACAATTTCTGAAGATGGTTATTAACACTGTGCTGTTAA
GCATCCATTTAAAAATATTTGTTATCTTCTTTGCCTGCCTGTATTTTAAAAAGAAATACAAAGTTGTAAAAGTAATGGATTTCTTTGGAT
GCTGAATGCAGTGATGTTATCAGTCAGATTCTTTCCTTGGCTCAGTTGTGTTTGTATTTCCTTTCTTAATTCCCCAAATCTTGGCTGGGC
ACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGTTCACTGGAGGTTGAGTTCGAGACCAGCCTGGCCACATG
GTGAAACCCTGTCTCTACTAAAGATATAAAAATTAGCTGGATGTGGTGGTGCACACCTGTGATCCCAGCTACTTGGGAGGCTGAGGTGGG
AGAATTGCTTGAACCTGGAAGGCAGAAGTTGCAGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGGTGACAGAGAGACTCTGTCTCA
AAAAAAAAAAGAAAAAATTCCCAAATCTTAATGTCTGTTTCAGAATTTTAGTGATTTTAAAGTGATAGTAGAAAATACCAAGCATATGAG
GTATTTCAATATGATAGGCTTCTTACATTTTAATAGTTACTCATCTTTGTTCCAGGACCCTTGACTGATGCTAGGGAAAGGATAAAGCAT
AGAATACCAGCCAGTTTGGCTCTGATTTTGAGTTATTTATAATAAAGTTTGGGGATTATCATAACATCTCATATCTTTGTGTATGTTGTT
TTAATGCTCGGCAGAGCACAACACTGATGATAACTATTAAAAATAGAAAATAACAGCCATTTTACTTTCAAATCTGATGTGATGCAATCT
GTGAACACTAGGAGGGGATAAAATAAGCATTGCAGGGAAACTTATTTGTAAATAGCTTCCTCACCTAAACTTTGACTTGGCAATCAATAC
TTTCTACTTTGTGGAGGGGATTAAGAATAGAATGGGCAGGATGAGACCATGAAAATTATAATGATTCATGTATATTTGTATGATGCTTGT
AACTTTGCAAAGTCTTTTTTATTCATTGTCTCATTTGGTCAGAACAATTTTATTGAGGACATGAATTTAACAATTAGAATTTAGATTTTC
TGACTGTAGCTACTAAATGTTGTAGCTACTAGACCAGGTGAGCTAGGTTTAGAGCAAAGTATATAAGCCTTGTATGGACTATATTAGAAT
TTTAAAAATTGTAATTAATTCCTTATCATCATTATAAAAAGCTTGATTTTTTTATTTGATCTAAAAAAGCATTATTCCAAAGAATTTTTT
CAAGTAGAAATGGGAGTTAGTTATACCAGTGTTGTTTTTAACTAATAAGGCTATTTTAGAATTCAGCCTTGCCTGTAAGGTCTTTGAGAA
GGGAGAGGAGTAGGCCAAAAAAAAAAAAGTCTTGATTCCTGAATGTGCCTTATATGCTGTGCCACTCACACCGAGGCCATCATCTCAACA
TTAGAGTTGTGCTAGATTACTGCTTGACTGACTAGCTAGGTTAGGCCTAAGAGTGTTTACCGAATAATCTGCACTCACTCAGTAGCCCTT
CTTCAGGATTAAAAACGATGATGACCTCATCTTAGAGCCCTAAAGGGAAATGCTTATGTGGGAACAAGAAAAGTCGGTGGTACTGTCTTC
TGCTACTACTACTTAGTGCTTTGCTGTGTATAGGGTGTGTTCACATATATCTCAGTTGAATGTCACAAGAATCCCTGAAGTGATTAAAAG
TCTTGAGAGGTCAGGCAATTTTTGTAAGGCTAGAAGGAAAAGTGAGGTTTTAGACTTCATTTCTTTTAAAGTTGGCAAACAAACATTTTC
TGTAATGGACAAGATAGATAGATTAGATAGATAGATAGATAGATAGATGATGATTGATTGATGATTGATAGTAAATTATTTCAGGCTTTG
CAGGCTATAAAGTGCTGCAGCTCCTTAGCTTTGCTGTTGTTATAGTGTAGCTGGAGCCATAGACAGTTAGTTAGTTAGTTATGAGTGAGC
ACAGCTGGGTGCCAGTACAATTTTAATGATCAAGACTCGTGGCAGGCAGAACAAACCATCATTTGTTGATCCTCTGCTTGAAAGCACGAA
TAAGTGAGAACAGAGCAGTCATATGGTTTCAGAAAGTGTTATTCTGGGATTTCAGGATAAATTTTGTAAAACTACTAACAAACAACACAC
AGGAAACTAATTTGGTATAAGAAACGACATATCCCTAAATAGTGCTTATTTAACTTCATTATAAATACATCTACTTAACAAAAAAATATA
TTTTGTGATCTTGAGGTCACTTCGTTTAGGTCATTATCTCAACCCAACCTCCCCAAACTCTGGTTTGAGCCAATATGTGTTCTATTGTTC
TCAGAGCACCAGCCGACTGTACAACAATTGTTATAAAAATGTTTATTGTTTACCAAAACCAGTGGACCTCTTATCAAATGCTGCTTGGTA

>95647_95647_1_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400518_USP14_chr18_202880_ENST00000261601_length(amino acids)=327AA_BP=286
MEDQAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD
IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST

--------------------------------------------------------------
>95647_95647_2_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400518_USP14_chr18_202880_ENST00000383589_length(transcript)=2365nt_BP=1043nt
CCGGACCTCAGGCCCAGTTCAGTGTACTTCCCCTCTCTACTTCCTCCCTCCAGTCCCTTCTCCATCCCTCCCTTTTTTGGCTGCCCCTTG
CCTGCCTTCCTCGCCAGTAGCTTGCAGAGTAGACACGATGACACCTTTTGCAGGCTAAAAAGGCTGAGAGTGGCACTATGTGCAGTGAGC
CACCATGGAGGACCAAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGC
CCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGT
GGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCA
GCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGA
CAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCT
GTCAGCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGA
TGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGG
GATTGGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGC
ATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAG
CACCACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAACGT
TGCAAAGAAATGCCTTGTATATCAAATCTTCCAAGATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATAAAG
AGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGATGTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTCAAG
AGAAAATGGTGTCTTTTCGATCCAAATTCAAGGATCTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTAGTC
CCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTTGCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTACTAA
CACACCAGGGAAGGTCTAGTTCTTCAGGTCATTATGTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACAAAG
TCAGCATCGTAACACCAGAAGATATCTTACGGCTTTCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCAGAG
TTGAAATAATGGAAGAGGAAAGTGAACAGTAATCTTCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCATTTC
TATAATCCAGAGCTTTAGAGGAAGACACATAGGTGGGTTTATGTTTCACCTCATTTGGAACAAAAGAGGACAGAAGCAGACCACTCTGTG
CACCAACCTAAAAAATTACAGAGAAGAGAAAATTATCTTTGGATTGTGCTGCCCTATATAAAGGTGGCAGAAAGACATTTTTAAAAAGCT
TATTATTTCTTGCATTATTTTAAAAAGTTCAGAGTTGAAATGCCTTTCAACCATTTCCTTCTGTGGTCATTTTTCTTGCTGCCTTTTTCA
CCCAAGATTCAGCAGTCAGATGTTTACTGCACACCTATTACCTATTATTTGCTGTTCTTGCATGGTTCAAACCACCATTCTGTAGCCACC
CATCCTTTGCCTTATCTAACAAACATTTTTCCAGGAAGGTGGAAAAGGAAGTGTTGCTCTCATTGTGTGACTCAGTGCTGCTGTCCATCC
CATGGAAACATGGGCACAATCAAGTATTTGTCCAGCCTATTGCAGGCTTTTCCTGACTTTAAAATAAATTGTGATCAATAATAGTACCTT
TGATTATACATTTATTATTGTGTCTCTCTCTGATGTACTGTGGATTGTACATTTAACTTTGGAATGGCTTTGTAATAATCAGTCTTAAGA

>95647_95647_2_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400518_USP14_chr18_202880_ENST00000383589_length(amino acids)=327AA_BP=286
MEDQAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD
IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST

--------------------------------------------------------------
>95647_95647_3_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400518_USP14_chr18_202880_ENST00000400266_length(transcript)=1718nt_BP=1043nt
CCGGACCTCAGGCCCAGTTCAGTGTACTTCCCCTCTCTACTTCCTCCCTCCAGTCCCTTCTCCATCCCTCCCTTTTTTGGCTGCCCCTTG
CCTGCCTTCCTCGCCAGTAGCTTGCAGAGTAGACACGATGACACCTTTTGCAGGCTAAAAAGGCTGAGAGTGGCACTATGTGCAGTGAGC
CACCATGGAGGACCAAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGC
CCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGT
GGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCA
GCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGA
CAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCT
GTCAGCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGA
TGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGG
GATTGGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGC
ATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAG
CACCACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAACGT
TGCAAAGAAATGCCTTGTATATCAAATCTTCCAAGATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATAAAG
AGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGATGTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTCAAG
AGAAAATGGTGTCTTTTCGATCCAAATTCAAGGATCTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTAGTC
CCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTTGCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTACTAA
CACACCAGGGAAGGTCTAGTTCTTCAGGTCATTATGTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACAAAG
TCAGCATCGTAACACCAGAAGATATCTTACGGCTTTCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCAGAG
TTGAAATAATGGAAGAGGAAAGTGAACAGTAATCTTCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCATTTC

>95647_95647_3_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400518_USP14_chr18_202880_ENST00000400266_length(amino acids)=327AA_BP=286
MEDQAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD
IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST

--------------------------------------------------------------
>95647_95647_4_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400518_USP14_chr18_202880_ENST00000582707_length(transcript)=1759nt_BP=1043nt
CCGGACCTCAGGCCCAGTTCAGTGTACTTCCCCTCTCTACTTCCTCCCTCCAGTCCCTTCTCCATCCCTCCCTTTTTTGGCTGCCCCTTG
CCTGCCTTCCTCGCCAGTAGCTTGCAGAGTAGACACGATGACACCTTTTGCAGGCTAAAAAGGCTGAGAGTGGCACTATGTGCAGTGAGC
CACCATGGAGGACCAAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGC
CCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGT
GGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCA
GCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGA
CAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCT
GTCAGCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGA
TGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGG
GATTGGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGC
ATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAG
CACCACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAACGT
TGCAAAGAAATGCCTTGTATATCAAATCTTCCAAGATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATAAAG
AGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGATGTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTCAAG
AGAAAATGGTGTCTTTTCGATCCAAATTCAAGGATCTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTAGTC
CCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTTGCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTACTAA
CACACCAGGGAAGGTCTAGTTCTTCAGGTCATTATGTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACAAAG
TCAGCATCGTAACACCAGAAGATATCTTACGGCTTTCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCAGAG
TTGAAATAATGGAAGAGGAAAGTGAACAGTAATCTTCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCATTTC

>95647_95647_4_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400518_USP14_chr18_202880_ENST00000582707_length(amino acids)=327AA_BP=286
MEDQAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD
IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST

--------------------------------------------------------------
>95647_95647_5_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400521_USP14_chr18_202880_ENST00000261601_length(transcript)=4910nt_BP=956nt
CACGACGATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAGGCCGTGGCGGGCGGGGTGCGGGG
CGCGGCGCGGGGCGCAGCAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGC
CGCCCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAA
CGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGC
CCAGCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCA
GGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCT
GCTGTCAGCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAG
TGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCAC
CGGGATTGGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACAT
GGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGA
CAGCACCACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAA
CGTTGCAAAGAAATGCCTTGTATATCAAATCTTCCAAGATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATA
AAGAGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGATGTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTC
AAGAGAAAATGGTGTCTTTTCGATCCAAATTCAAGGATCTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTA
GTCCCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTTGCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTAC
TAACACACCAGGGAAGGTCTAGTTCTTCAGGTCATTATGTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACA
AAGTCAGCATCGTAACACCAGAAGATATCTTACGGCTTTCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCA
GAGTTGAAATAATGGAAGAGGAAAGTGAACAGTAATCTTCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCAT
TTCTATAATCCAGAGCTTTAGAGGAAGACACATAGGTGGGTTTATGTTTCACCTCATTTGGAACAAAAGAGGACAGAAGCAGACCACTCT
GTGCACCAACCTAAAAAATTACAGAGAAGAGAAAATTATCTTTGGATTGTGCTGCCCTATATAAAGGTGGCAGAAAGACATTTTTAAAAA
GCTTATTATTTCTTGCATTATTTTAAAAAGTTCAGAGTTGAAATGCCTTTCAACCATTTCCTTCTGTGGTCATTTTTCTTGCTGCCTTTT
TCACCCAAGATTCAGCAGTCAGATGTTTACTGCACACCTATTACCTATTATTTGCTGTTCTTGCATGGTTCAAACCACCATTCTGTAGCC
ACCCATCCTTTGCCTTATCTAACAAACATTTTTCCAGGAAGGTGGAAAAGGAAGTGTTGCTCTCATTGTGTGACTCAGTGCTGCTGTCCA
TCCCATGGAAACATGGGCACAATCAAGTATTTGTCCAGCCTATTGCAGGCTTTTCCTGACTTTAAAATAAATTGTGATCAATAATAGTAC
CTTTGATTATACATTTATTATTGTGTCTCTCTCTGATGTACTGTGGATTGTACATTTAACTTTGGAATGGCTTTGTAATAATCAGTCTTA
AGAAAATGTTGACAAGCTCTGGTTGCTTATTTTTAGAAAATGAGGACATTTAATAATAATAAAAAAAAAGGGATTAATAGCTTTTGACCT
CAAGTCTTTTGTCTTCTGAGTGTTGGAGCTTGGCTGAAGACATGTTTAATACTGTACAATTTCTGAAGATGGTTATTAACACTGTGCTGT
TAAGCATCCATTTAAAAATATTTGTTATCTTCTTTGCCTGCCTGTATTTTAAAAAGAAATACAAAGTTGTAAAAGTAATGGATTTCTTTG
GATGCTGAATGCAGTGATGTTATCAGTCAGATTCTTTCCTTGGCTCAGTTGTGTTTGTATTTCCTTTCTTAATTCCCCAAATCTTGGCTG
GGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGTTCACTGGAGGTTGAGTTCGAGACCAGCCTGGCCAC
ATGGTGAAACCCTGTCTCTACTAAAGATATAAAAATTAGCTGGATGTGGTGGTGCACACCTGTGATCCCAGCTACTTGGGAGGCTGAGGT
GGGAGAATTGCTTGAACCTGGAAGGCAGAAGTTGCAGTGAGCTGAGATCACACCACTGCACTCCAGCCTGGGTGACAGAGAGACTCTGTC
TCAAAAAAAAAAAGAAAAAATTCCCAAATCTTAATGTCTGTTTCAGAATTTTAGTGATTTTAAAGTGATAGTAGAAAATACCAAGCATAT
GAGGTATTTCAATATGATAGGCTTCTTACATTTTAATAGTTACTCATCTTTGTTCCAGGACCCTTGACTGATGCTAGGGAAAGGATAAAG
CATAGAATACCAGCCAGTTTGGCTCTGATTTTGAGTTATTTATAATAAAGTTTGGGGATTATCATAACATCTCATATCTTTGTGTATGTT
GTTTTAATGCTCGGCAGAGCACAACACTGATGATAACTATTAAAAATAGAAAATAACAGCCATTTTACTTTCAAATCTGATGTGATGCAA
TCTGTGAACACTAGGAGGGGATAAAATAAGCATTGCAGGGAAACTTATTTGTAAATAGCTTCCTCACCTAAACTTTGACTTGGCAATCAA
TACTTTCTACTTTGTGGAGGGGATTAAGAATAGAATGGGCAGGATGAGACCATGAAAATTATAATGATTCATGTATATTTGTATGATGCT
TGTAACTTTGCAAAGTCTTTTTTATTCATTGTCTCATTTGGTCAGAACAATTTTATTGAGGACATGAATTTAACAATTAGAATTTAGATT
TTCTGACTGTAGCTACTAAATGTTGTAGCTACTAGACCAGGTGAGCTAGGTTTAGAGCAAAGTATATAAGCCTTGTATGGACTATATTAG
AATTTTAAAAATTGTAATTAATTCCTTATCATCATTATAAAAAGCTTGATTTTTTTATTTGATCTAAAAAAGCATTATTCCAAAGAATTT
TTTCAAGTAGAAATGGGAGTTAGTTATACCAGTGTTGTTTTTAACTAATAAGGCTATTTTAGAATTCAGCCTTGCCTGTAAGGTCTTTGA
GAAGGGAGAGGAGTAGGCCAAAAAAAAAAAAGTCTTGATTCCTGAATGTGCCTTATATGCTGTGCCACTCACACCGAGGCCATCATCTCA
ACATTAGAGTTGTGCTAGATTACTGCTTGACTGACTAGCTAGGTTAGGCCTAAGAGTGTTTACCGAATAATCTGCACTCACTCAGTAGCC
CTTCTTCAGGATTAAAAACGATGATGACCTCATCTTAGAGCCCTAAAGGGAAATGCTTATGTGGGAACAAGAAAAGTCGGTGGTACTGTC
TTCTGCTACTACTACTTAGTGCTTTGCTGTGTATAGGGTGTGTTCACATATATCTCAGTTGAATGTCACAAGAATCCCTGAAGTGATTAA
AAGTCTTGAGAGGTCAGGCAATTTTTGTAAGGCTAGAAGGAAAAGTGAGGTTTTAGACTTCATTTCTTTTAAAGTTGGCAAACAAACATT
TTCTGTAATGGACAAGATAGATAGATTAGATAGATAGATAGATAGATAGATGATGATTGATTGATGATTGATAGTAAATTATTTCAGGCT
TTGCAGGCTATAAAGTGCTGCAGCTCCTTAGCTTTGCTGTTGTTATAGTGTAGCTGGAGCCATAGACAGTTAGTTAGTTAGTTATGAGTG
AGCACAGCTGGGTGCCAGTACAATTTTAATGATCAAGACTCGTGGCAGGCAGAACAAACCATCATTTGTTGATCCTCTGCTTGAAAGCAC
GAATAAGTGAGAACAGAGCAGTCATATGGTTTCAGAAAGTGTTATTCTGGGATTTCAGGATAAATTTTGTAAAACTACTAACAAACAACA
CACAGGAAACTAATTTGGTATAAGAAACGACATATCCCTAAATAGTGCTTATTTAACTTCATTATAAATACATCTACTTAACAAAAAAAT
ATATTTTGTGATCTTGAGGTCACTTCGTTTAGGTCATTATCTCAACCCAACCTCCCCAAACTCTGGTTTGAGCCAATATGTGTTCTATTG
TTCTCAGAGCACCAGCCGACTGTACAACAATTGTTATAAAAATGTTTATTGTTTACCAAAACCAGTGGACCTCTTATCAAATGCTGCTTG

>95647_95647_5_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400521_USP14_chr18_202880_ENST00000261601_length(amino acids)=357AA_BP=316
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVG
CIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLS
ADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS

--------------------------------------------------------------
>95647_95647_6_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400521_USP14_chr18_202880_ENST00000383589_length(transcript)=2278nt_BP=956nt
CACGACGATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAGGCCGTGGCGGGCGGGGTGCGGGG
CGCGGCGCGGGGCGCAGCAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGC
CGCCCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAA
CGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGC
CCAGCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCA
GGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCT
GCTGTCAGCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAG
TGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCAC
CGGGATTGGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACAT
GGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGA
CAGCACCACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAA
CGTTGCAAAGAAATGCCTTGTATATCAAATCTTCCAAGATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATA
AAGAGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGATGTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTC
AAGAGAAAATGGTGTCTTTTCGATCCAAATTCAAGGATCTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTA
GTCCCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTTGCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTAC
TAACACACCAGGGAAGGTCTAGTTCTTCAGGTCATTATGTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACA
AAGTCAGCATCGTAACACCAGAAGATATCTTACGGCTTTCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCA
GAGTTGAAATAATGGAAGAGGAAAGTGAACAGTAATCTTCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCAT
TTCTATAATCCAGAGCTTTAGAGGAAGACACATAGGTGGGTTTATGTTTCACCTCATTTGGAACAAAAGAGGACAGAAGCAGACCACTCT
GTGCACCAACCTAAAAAATTACAGAGAAGAGAAAATTATCTTTGGATTGTGCTGCCCTATATAAAGGTGGCAGAAAGACATTTTTAAAAA
GCTTATTATTTCTTGCATTATTTTAAAAAGTTCAGAGTTGAAATGCCTTTCAACCATTTCCTTCTGTGGTCATTTTTCTTGCTGCCTTTT
TCACCCAAGATTCAGCAGTCAGATGTTTACTGCACACCTATTACCTATTATTTGCTGTTCTTGCATGGTTCAAACCACCATTCTGTAGCC
ACCCATCCTTTGCCTTATCTAACAAACATTTTTCCAGGAAGGTGGAAAAGGAAGTGTTGCTCTCATTGTGTGACTCAGTGCTGCTGTCCA
TCCCATGGAAACATGGGCACAATCAAGTATTTGTCCAGCCTATTGCAGGCTTTTCCTGACTTTAAAATAAATTGTGATCAATAATAGTAC
CTTTGATTATACATTTATTATTGTGTCTCTCTCTGATGTACTGTGGATTGTACATTTAACTTTGGAATGGCTTTGTAATAATCAGTCTTA

>95647_95647_6_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400521_USP14_chr18_202880_ENST00000383589_length(amino acids)=357AA_BP=316
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVG
CIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLS
ADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS

--------------------------------------------------------------
>95647_95647_7_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400521_USP14_chr18_202880_ENST00000400266_length(transcript)=1631nt_BP=956nt
CACGACGATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAGGCCGTGGCGGGCGGGGTGCGGGG
CGCGGCGCGGGGCGCAGCAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGC
CGCCCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAA
CGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGC
CCAGCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCA
GGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCT
GCTGTCAGCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAG
TGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCAC
CGGGATTGGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACAT
GGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGA
CAGCACCACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAA
CGTTGCAAAGAAATGCCTTGTATATCAAATCTTCCAAGATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATA
AAGAGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGATGTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTC
AAGAGAAAATGGTGTCTTTTCGATCCAAATTCAAGGATCTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTA
GTCCCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTTGCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTAC
TAACACACCAGGGAAGGTCTAGTTCTTCAGGTCATTATGTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACA
AAGTCAGCATCGTAACACCAGAAGATATCTTACGGCTTTCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCA
GAGTTGAAATAATGGAAGAGGAAAGTGAACAGTAATCTTCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCAT

>95647_95647_7_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400521_USP14_chr18_202880_ENST00000400266_length(amino acids)=357AA_BP=316
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVG
CIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLS
ADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS

--------------------------------------------------------------
>95647_95647_8_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400521_USP14_chr18_202880_ENST00000582707_length(transcript)=1672nt_BP=956nt
CACGACGATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAGGCCGTGGCGGGCGGGGTGCGGGG
CGCGGCGCGGGGCGCAGCAGCAGGTCAGCGGGACTATGATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGC
CGCCCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAA
CGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGGCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGC
CCAGCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCA
GGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCTTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCT
GCTGTCAGCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAG
TGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCAC
CGGGATTGGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACAT
GGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCCCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGA
CAGCACCACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAA
CGTTGCAAAGAAATGCCTTGTATATCAAATCTTCCAAGATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATA
AAGAGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGATGTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTC
AAGAGAAAATGGTGTCTTTTCGATCCAAATTCAAGGATCTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTA
GTCCCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTTGCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTAC
TAACACACCAGGGAAGGTCTAGTTCTTCAGGTCATTATGTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACA
AAGTCAGCATCGTAACACCAGAAGATATCTTACGGCTTTCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCA
GAGTTGAAATAATGGAAGAGGAAAGTGAACAGTAATCTTCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCAT

>95647_95647_8_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000400521_USP14_chr18_202880_ENST00000582707_length(amino acids)=357AA_BP=316
MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVG
CIPKKLMHQAALLGGLIQDAPNYGWEVAQPVPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLS
ADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMAS

--------------------------------------------------------------
>95647_95647_9_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000542719_USP14_chr18_202880_ENST00000261601_length(transcript)=4872nt_BP=918nt
CGATGACACCTTTTGCAGGCTAAAAAGGCTGAGAGTGGCACTATGTGCAGTGAGCCACCATGGAGGACCAAGCAGGTCAGCGGGACTATG
ATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACG
TGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGG
CACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAG
CTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCT
TTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCAGCCGATCACATCATCATTGCTACTGGAGGGC
GGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAA
CGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATTGGGCTGGACACCACCATCATGATGCGCAGCA
TCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCC
CCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACCACCGGCAAGGAGGACACGGGCACCTTTGACA
CCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAACGTTGCAAAGAAATGCCTTGTATATCAAATCTTCCAAG
ATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATAAAGAGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGAT
GTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTCAAGAGAAAATGGTGTCTTTTCGATCCAAATTCAAGGAT
CTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTAGTCCCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTT
GCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTACTAACACACCAGGGAAGGTCTAGTTCTTCAGGTCATTAT
GTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACAAAGTCAGCATCGTAACACCAGAAGATATCTTACGGCTT
TCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCAGAGTTGAAATAATGGAAGAGGAAAGTGAACAGTAATCT
TCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCATTTCTATAATCCAGAGCTTTAGAGGAAGACACATAGGTG
GGTTTATGTTTCACCTCATTTGGAACAAAAGAGGACAGAAGCAGACCACTCTGTGCACCAACCTAAAAAATTACAGAGAAGAGAAAATTA
TCTTTGGATTGTGCTGCCCTATATAAAGGTGGCAGAAAGACATTTTTAAAAAGCTTATTATTTCTTGCATTATTTTAAAAAGTTCAGAGT
TGAAATGCCTTTCAACCATTTCCTTCTGTGGTCATTTTTCTTGCTGCCTTTTTCACCCAAGATTCAGCAGTCAGATGTTTACTGCACACC
TATTACCTATTATTTGCTGTTCTTGCATGGTTCAAACCACCATTCTGTAGCCACCCATCCTTTGCCTTATCTAACAAACATTTTTCCAGG
AAGGTGGAAAAGGAAGTGTTGCTCTCATTGTGTGACTCAGTGCTGCTGTCCATCCCATGGAAACATGGGCACAATCAAGTATTTGTCCAG
CCTATTGCAGGCTTTTCCTGACTTTAAAATAAATTGTGATCAATAATAGTACCTTTGATTATACATTTATTATTGTGTCTCTCTCTGATG
TACTGTGGATTGTACATTTAACTTTGGAATGGCTTTGTAATAATCAGTCTTAAGAAAATGTTGACAAGCTCTGGTTGCTTATTTTTAGAA
AATGAGGACATTTAATAATAATAAAAAAAAAGGGATTAATAGCTTTTGACCTCAAGTCTTTTGTCTTCTGAGTGTTGGAGCTTGGCTGAA
GACATGTTTAATACTGTACAATTTCTGAAGATGGTTATTAACACTGTGCTGTTAAGCATCCATTTAAAAATATTTGTTATCTTCTTTGCC
TGCCTGTATTTTAAAAAGAAATACAAAGTTGTAAAAGTAATGGATTTCTTTGGATGCTGAATGCAGTGATGTTATCAGTCAGATTCTTTC
CTTGGCTCAGTTGTGTTTGTATTTCCTTTCTTAATTCCCCAAATCTTGGCTGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGG
AGGCTGAGGCAGGTGGTTCACTGGAGGTTGAGTTCGAGACCAGCCTGGCCACATGGTGAAACCCTGTCTCTACTAAAGATATAAAAATTA
GCTGGATGTGGTGGTGCACACCTGTGATCCCAGCTACTTGGGAGGCTGAGGTGGGAGAATTGCTTGAACCTGGAAGGCAGAAGTTGCAGT
GAGCTGAGATCACACCACTGCACTCCAGCCTGGGTGACAGAGAGACTCTGTCTCAAAAAAAAAAAGAAAAAATTCCCAAATCTTAATGTC
TGTTTCAGAATTTTAGTGATTTTAAAGTGATAGTAGAAAATACCAAGCATATGAGGTATTTCAATATGATAGGCTTCTTACATTTTAATA
GTTACTCATCTTTGTTCCAGGACCCTTGACTGATGCTAGGGAAAGGATAAAGCATAGAATACCAGCCAGTTTGGCTCTGATTTTGAGTTA
TTTATAATAAAGTTTGGGGATTATCATAACATCTCATATCTTTGTGTATGTTGTTTTAATGCTCGGCAGAGCACAACACTGATGATAACT
ATTAAAAATAGAAAATAACAGCCATTTTACTTTCAAATCTGATGTGATGCAATCTGTGAACACTAGGAGGGGATAAAATAAGCATTGCAG
GGAAACTTATTTGTAAATAGCTTCCTCACCTAAACTTTGACTTGGCAATCAATACTTTCTACTTTGTGGAGGGGATTAAGAATAGAATGG
GCAGGATGAGACCATGAAAATTATAATGATTCATGTATATTTGTATGATGCTTGTAACTTTGCAAAGTCTTTTTTATTCATTGTCTCATT
TGGTCAGAACAATTTTATTGAGGACATGAATTTAACAATTAGAATTTAGATTTTCTGACTGTAGCTACTAAATGTTGTAGCTACTAGACC
AGGTGAGCTAGGTTTAGAGCAAAGTATATAAGCCTTGTATGGACTATATTAGAATTTTAAAAATTGTAATTAATTCCTTATCATCATTAT
AAAAAGCTTGATTTTTTTATTTGATCTAAAAAAGCATTATTCCAAAGAATTTTTTCAAGTAGAAATGGGAGTTAGTTATACCAGTGTTGT
TTTTAACTAATAAGGCTATTTTAGAATTCAGCCTTGCCTGTAAGGTCTTTGAGAAGGGAGAGGAGTAGGCCAAAAAAAAAAAAGTCTTGA
TTCCTGAATGTGCCTTATATGCTGTGCCACTCACACCGAGGCCATCATCTCAACATTAGAGTTGTGCTAGATTACTGCTTGACTGACTAG
CTAGGTTAGGCCTAAGAGTGTTTACCGAATAATCTGCACTCACTCAGTAGCCCTTCTTCAGGATTAAAAACGATGATGACCTCATCTTAG
AGCCCTAAAGGGAAATGCTTATGTGGGAACAAGAAAAGTCGGTGGTACTGTCTTCTGCTACTACTACTTAGTGCTTTGCTGTGTATAGGG
TGTGTTCACATATATCTCAGTTGAATGTCACAAGAATCCCTGAAGTGATTAAAAGTCTTGAGAGGTCAGGCAATTTTTGTAAGGCTAGAA
GGAAAAGTGAGGTTTTAGACTTCATTTCTTTTAAAGTTGGCAAACAAACATTTTCTGTAATGGACAAGATAGATAGATTAGATAGATAGA
TAGATAGATAGATGATGATTGATTGATGATTGATAGTAAATTATTTCAGGCTTTGCAGGCTATAAAGTGCTGCAGCTCCTTAGCTTTGCT
GTTGTTATAGTGTAGCTGGAGCCATAGACAGTTAGTTAGTTAGTTATGAGTGAGCACAGCTGGGTGCCAGTACAATTTTAATGATCAAGA
CTCGTGGCAGGCAGAACAAACCATCATTTGTTGATCCTCTGCTTGAAAGCACGAATAAGTGAGAACAGAGCAGTCATATGGTTTCAGAAA
GTGTTATTCTGGGATTTCAGGATAAATTTTGTAAAACTACTAACAAACAACACACAGGAAACTAATTTGGTATAAGAAACGACATATCCC
TAAATAGTGCTTATTTAACTTCATTATAAATACATCTACTTAACAAAAAAATATATTTTGTGATCTTGAGGTCACTTCGTTTAGGTCATT
ATCTCAACCCAACCTCCCCAAACTCTGGTTTGAGCCAATATGTGTTCTATTGTTCTCAGAGCACCAGCCGACTGTACAACAATTGTTATA
AAAATGTTTATTGTTTACCAAAACCAGTGGACCTCTTATCAAATGCTGCTTGGTAACAAAATCTATCACAGTTTTAATAAAAAGAAAAAA

>95647_95647_9_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000542719_USP14_chr18_202880_ENST00000261601_length(amino acids)=327AA_BP=286
MEDQAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD
IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST

--------------------------------------------------------------
>95647_95647_10_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000542719_USP14_chr18_202880_ENST00000383589_length(transcript)=2240nt_BP=918nt
CGATGACACCTTTTGCAGGCTAAAAAGGCTGAGAGTGGCACTATGTGCAGTGAGCCACCATGGAGGACCAAGCAGGTCAGCGGGACTATG
ATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACG
TGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGG
CACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAG
CTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCT
TTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCAGCCGATCACATCATCATTGCTACTGGAGGGC
GGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAA
CGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATTGGGCTGGACACCACCATCATGATGCGCAGCA
TCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCC
CCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACCACCGGCAAGGAGGACACGGGCACCTTTGACA
CCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAACGTTGCAAAGAAATGCCTTGTATATCAAATCTTCCAAG
ATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATAAAGAGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGAT
GTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTCAAGAGAAAATGGTGTCTTTTCGATCCAAATTCAAGGAT
CTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTAGTCCCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTT
GCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTACTAACACACCAGGGAAGGTCTAGTTCTTCAGGTCATTAT
GTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACAAAGTCAGCATCGTAACACCAGAAGATATCTTACGGCTT
TCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCAGAGTTGAAATAATGGAAGAGGAAAGTGAACAGTAATCT
TCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCATTTCTATAATCCAGAGCTTTAGAGGAAGACACATAGGTG
GGTTTATGTTTCACCTCATTTGGAACAAAAGAGGACAGAAGCAGACCACTCTGTGCACCAACCTAAAAAATTACAGAGAAGAGAAAATTA
TCTTTGGATTGTGCTGCCCTATATAAAGGTGGCAGAAAGACATTTTTAAAAAGCTTATTATTTCTTGCATTATTTTAAAAAGTTCAGAGT
TGAAATGCCTTTCAACCATTTCCTTCTGTGGTCATTTTTCTTGCTGCCTTTTTCACCCAAGATTCAGCAGTCAGATGTTTACTGCACACC
TATTACCTATTATTTGCTGTTCTTGCATGGTTCAAACCACCATTCTGTAGCCACCCATCCTTTGCCTTATCTAACAAACATTTTTCCAGG
AAGGTGGAAAAGGAAGTGTTGCTCTCATTGTGTGACTCAGTGCTGCTGTCCATCCCATGGAAACATGGGCACAATCAAGTATTTGTCCAG
CCTATTGCAGGCTTTTCCTGACTTTAAAATAAATTGTGATCAATAATAGTACCTTTGATTATACATTTATTATTGTGTCTCTCTCTGATG

>95647_95647_10_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000542719_USP14_chr18_202880_ENST00000383589_length(amino acids)=327AA_BP=286
MEDQAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD
IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST

--------------------------------------------------------------
>95647_95647_11_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000542719_USP14_chr18_202880_ENST00000400266_length(transcript)=1593nt_BP=918nt
CGATGACACCTTTTGCAGGCTAAAAAGGCTGAGAGTGGCACTATGTGCAGTGAGCCACCATGGAGGACCAAGCAGGTCAGCGGGACTATG
ATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACG
TGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGG
CACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAG
CTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCT
TTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCAGCCGATCACATCATCATTGCTACTGGAGGGC
GGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAA
CGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATTGGGCTGGACACCACCATCATGATGCGCAGCA
TCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCC
CCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACCACCGGCAAGGAGGACACGGGCACCTTTGACA
CCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAACGTTGCAAAGAAATGCCTTGTATATCAAATCTTCCAAG
ATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATAAAGAGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGAT
GTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTCAAGAGAAAATGGTGTCTTTTCGATCCAAATTCAAGGAT
CTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTAGTCCCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTT
GCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTACTAACACACCAGGGAAGGTCTAGTTCTTCAGGTCATTAT
GTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACAAAGTCAGCATCGTAACACCAGAAGATATCTTACGGCTT
TCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCAGAGTTGAAATAATGGAAGAGGAAAGTGAACAGTAATCT

>95647_95647_11_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000542719_USP14_chr18_202880_ENST00000400266_length(amino acids)=327AA_BP=286
MEDQAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD
IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST

--------------------------------------------------------------
>95647_95647_12_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000542719_USP14_chr18_202880_ENST00000582707_length(transcript)=1634nt_BP=918nt
CGATGACACCTTTTGCAGGCTAAAAAGGCTGAGAGTGGCACTATGTGCAGTGAGCCACCATGGAGGACCAAGCAGGTCAGCGGGACTATG
ATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAGCTGGGAAGGAAGGTGGCCGTGGTGGACTACG
TGGAACCTTCTCCCCAAGGCACCCGGTGGGGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCGG
CACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCCGTGCCGCATGACTGGAGGAAGATGGCAGAAG
CTGTTCAAAATCACGTGAAATCCTTGAACTGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGCT
TTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCAGCCGATCACATCATCATTGCTACTGGAGGGC
GGCCGAGATACCCCACGCACATCGAAGGTGCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAAA
CGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATTGGGCTGGACACCACCATCATGATGCGCAGCA
TCCCCCTCCGCGGCTTCGACCAGCAAATGTCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCCC
CCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACCACCGGCAAGGAGGACACGGGCACCTTTGACA
CCGTCCTGTGGGCCATAGCGACTTCAGGAAGAAATCACCAAACAGTCTCCAACGTTGCAAAGAAATGCCTTGTATATCAAATCTTCCAAG
ATCAGCCGGCTGCCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATAAAGAGAAGGAATCTGTGAATGCCAAAGTTCTTAAGGAT
GTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACACCAGAACTTCAAGAGAAAATGGTGTCTTTTCGATCCAAATTCAAGGAT
CTAGAAGATAAAAAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTAGTCCCCAGAAAGAAGTTAAGTATGAACCCTTTTCTTTT
GCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTACAAGCAGTACTAACACACCAGGGAAGGTCTAGTTCTTCAGGTCATTAT
GTATCATGGGTGAAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACAAAGTCAGCATCGTAACACCAGAAGATATCTTACGGCTT
TCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTATGGGCCTCGCAGAGTTGAAATAATGGAAGAGGAAAGTGAACAGTAATCT
TCATTTTAGTATTTATGCTTAGATGTGAAAATAAATGTTATTTGTTGATCATTTCTATAATCCAGAGCTTTAGAGGAAGACACATAGGTG

>95647_95647_12_TXNRD2-USP14_TXNRD2_chr22_19882930_ENST00000542719_USP14_chr18_202880_ENST00000582707_length(amino acids)=327AA_BP=286
MEDQAGQRDYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDD
IFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TXNRD2-USP14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TXNRD2-USP14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TXNRD2-USP14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource