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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TYK2-ZNRF1 (FusionGDB2 ID:95660)

Fusion Gene Summary for TYK2-ZNRF1

check button Fusion gene summary
Fusion gene informationFusion gene name: TYK2-ZNRF1
Fusion gene ID: 95660
HgeneTgene
Gene symbol

TYK2

ZNRF1

Gene ID

7297

84937

Gene nametyrosine kinase 2zinc and ring finger 1
SynonymsIMD35|JTK1NIN283
Cytomap

19p13.2

16q23.1

Type of geneprotein-codingprotein-coding
Descriptionnon-receptor tyrosine-protein kinase TYK2E3 ubiquitin-protein ligase ZNRF1RING-type E3 ubiquitin transferase ZNRF1nerve injury gene 283nerve injury-induced gene 283 proteinzinc and ring finger 1, E3 ubiquitin protein ligasezinc and ring finger protein 1zinc/RING finger protein 1
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264818, ENST00000525621, 
ENST00000529370, ENST00000524462, 
ENST00000529422, 		ENST00000564320, 
ENST00000320619, ENST00000335325, 
ENST00000566250, ENST00000567962, 
Fusion gene scores* DoF score13 X 11 X 8=11447 X 7 X 6=294
# samples 159
** MAII scorelog2(15/1144*10)=-2.93105264628251
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/294*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TYK2 [Title/Abstract] AND ZNRF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTYK2(10488889)-ZNRF1(75127469), # samples:1
Anticipated loss of major functional domain due to fusion event.TYK2-ZNRF1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TYK2-ZNRF1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TYK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNRF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-30-1866TYK2chr19

10488889

-ZNRF1chr16

75127469

+


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Fusion Gene ORF analysis for TYK2-ZNRF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000264818ENST00000564320TYK2chr19

10488889

-ZNRF1chr16

75127469

+
5CDS-3UTRENST00000525621ENST00000564320TYK2chr19

10488889

-ZNRF1chr16

75127469

+
5CDS-3UTRENST00000529370ENST00000564320TYK2chr19

10488889

-ZNRF1chr16

75127469

+
Frame-shiftENST00000264818ENST00000320619TYK2chr19

10488889

-ZNRF1chr16

75127469

+
Frame-shiftENST00000264818ENST00000335325TYK2chr19

10488889

-ZNRF1chr16

75127469

+
Frame-shiftENST00000264818ENST00000566250TYK2chr19

10488889

-ZNRF1chr16

75127469

+
Frame-shiftENST00000264818ENST00000567962TYK2chr19

10488889

-ZNRF1chr16

75127469

+
In-frameENST00000525621ENST00000320619TYK2chr19

10488889

-ZNRF1chr16

75127469

+
In-frameENST00000525621ENST00000335325TYK2chr19

10488889

-ZNRF1chr16

75127469

+
In-frameENST00000525621ENST00000566250TYK2chr19

10488889

-ZNRF1chr16

75127469

+
In-frameENST00000525621ENST00000567962TYK2chr19

10488889

-ZNRF1chr16

75127469

+
In-frameENST00000529370ENST00000320619TYK2chr19

10488889

-ZNRF1chr16

75127469

+
In-frameENST00000529370ENST00000335325TYK2chr19

10488889

-ZNRF1chr16

75127469

+
In-frameENST00000529370ENST00000566250TYK2chr19

10488889

-ZNRF1chr16

75127469

+
In-frameENST00000529370ENST00000567962TYK2chr19

10488889

-ZNRF1chr16

75127469

+
intron-3CDSENST00000524462ENST00000320619TYK2chr19

10488889

-ZNRF1chr16

75127469

+
intron-3CDSENST00000524462ENST00000335325TYK2chr19

10488889

-ZNRF1chr16

75127469

+
intron-3CDSENST00000524462ENST00000566250TYK2chr19

10488889

-ZNRF1chr16

75127469

+
intron-3CDSENST00000524462ENST00000567962TYK2chr19

10488889

-ZNRF1chr16

75127469

+
intron-3CDSENST00000529422ENST00000320619TYK2chr19

10488889

-ZNRF1chr16

75127469

+
intron-3CDSENST00000529422ENST00000335325TYK2chr19

10488889

-ZNRF1chr16

75127469

+
intron-3CDSENST00000529422ENST00000566250TYK2chr19

10488889

-ZNRF1chr16

75127469

+
intron-3CDSENST00000529422ENST00000567962TYK2chr19

10488889

-ZNRF1chr16

75127469

+
intron-3UTRENST00000524462ENST00000564320TYK2chr19

10488889

-ZNRF1chr16

75127469

+
intron-3UTRENST00000529422ENST00000564320TYK2chr19

10488889

-ZNRF1chr16

75127469

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000525621TYK2chr1910488889-ENST00000335325ZNRF1chr1675127469+422967521582625155
ENST00000525621TYK2chr1910488889-ENST00000320619ZNRF1chr1675127469+20956754821087201
ENST00000525621TYK2chr1910488889-ENST00000566250ZNRF1chr1675127469+993675482880132
ENST00000525621TYK2chr1910488889-ENST00000567962ZNRF1chr1675127469+1158675482934150
ENST00000529370TYK2chr1910488889-ENST00000335325ZNRF1chr1675127469+407852420072474155
ENST00000529370TYK2chr1910488889-ENST00000320619ZNRF1chr1675127469+1944524331936201
ENST00000529370TYK2chr1910488889-ENST00000566250ZNRF1chr1675127469+842524331729132
ENST00000529370TYK2chr1910488889-ENST00000567962ZNRF1chr1675127469+1007524331783150

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000525621ENST00000335325TYK2chr1910488889-ZNRF1chr1675127469+0.749502960.250497
ENST00000525621ENST00000320619TYK2chr1910488889-ZNRF1chr1675127469+0.181697120.8183029
ENST00000525621ENST00000566250TYK2chr1910488889-ZNRF1chr1675127469+0.06925510.9307449
ENST00000525621ENST00000567962TYK2chr1910488889-ZNRF1chr1675127469+0.0518035670.9481965
ENST00000529370ENST00000335325TYK2chr1910488889-ZNRF1chr1675127469+0.775382460.22461751
ENST00000529370ENST00000320619TYK2chr1910488889-ZNRF1chr1675127469+0.219774350.7802256
ENST00000529370ENST00000566250TYK2chr1910488889-ZNRF1chr1675127469+0.053443940.9465561
ENST00000529370ENST00000567962TYK2chr1910488889-ZNRF1chr1675127469+0.0503799770.94962

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Fusion Genomic Features for TYK2-ZNRF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TYK2chr1910488889-ZNRF1chr1675127469+0.0100480610.9899519
TYK2chr1910488889-ZNRF1chr1675127469+0.0100480610.9899519

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TYK2-ZNRF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10488889/chr16:75127469)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZNRF1chr19:10488889chr16:75127469ENST0000032061906184_225141251.0Zinc fingerRING-type%3B atypical
TgeneZNRF1chr19:10488889chr16:75127469ENST0000033532505184_225141960.0Zinc fingerRING-type%3B atypical
TgeneZNRF1chr19:10488889chr16:75127469ENST0000056796205184_22514141.333333333333336Zinc fingerRING-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTYK2chr19:10488889chr16:75127469ENST00000264818-12326_431641188.0DomainFERM
HgeneTYK2chr19:10488889chr16:75127469ENST00000264818-123450_529641188.0DomainNote=SH2%3B atypical
HgeneTYK2chr19:10488889chr16:75127469ENST00000264818-123589_875641188.0DomainProtein kinase 1
HgeneTYK2chr19:10488889chr16:75127469ENST00000264818-123897_1176641188.0DomainProtein kinase 2
HgeneTYK2chr19:10488889chr16:75127469ENST00000525621-32526_431641188.0DomainFERM
HgeneTYK2chr19:10488889chr16:75127469ENST00000525621-325450_529641188.0DomainNote=SH2%3B atypical
HgeneTYK2chr19:10488889chr16:75127469ENST00000525621-325589_875641188.0DomainProtein kinase 1
HgeneTYK2chr19:10488889chr16:75127469ENST00000525621-325897_1176641188.0DomainProtein kinase 2
HgeneTYK2chr19:10488889chr16:75127469ENST00000264818-123903_911641188.0Nucleotide bindingATP
HgeneTYK2chr19:10488889chr16:75127469ENST00000525621-325903_911641188.0Nucleotide bindingATP
TgeneZNRF1chr19:10488889chr16:75127469ENST00000320619062_10141251.0RegionNote=Required for endosomal and lysosomal localization and myristoylation
TgeneZNRF1chr19:10488889chr16:75127469ENST00000335325052_10141960.0RegionNote=Required for endosomal and lysosomal localization and myristoylation
TgeneZNRF1chr19:10488889chr16:75127469ENST00000567962052_1014141.333333333333336RegionNote=Required for endosomal and lysosomal localization and myristoylation


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Fusion Gene Sequence for TYK2-ZNRF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95660_95660_1_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000525621_ZNRF1_chr16_75127469_ENST00000320619_length(transcript)=2095nt_BP=675nt
AAAAAAAAAAAAATCCAATGGTGACGAGCAGGGAGAACAGAGCAGCTGCCAATGGGCGTGTGCGTTTCAGGCGGCCAATGGGAGGAGGCG
TCTCGGCGGGGGACAAGCAGTAGCTACCCGCGGGAGCGGGGAGGGGTCCGGGTTCGAGCTTGTGTTCCCCCGGAAGGGTGAGTCTGGACG
CGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCTTGACAGGCTGCACTTGGATGGGAGCACCT
GGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATATTGAAACATTACAACCATCTTTTGATGGC
AACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGCTTGCTTGAGTTGACACAGGGAGCTCCAGG
ACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCC
AGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCAT
CGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGGTTTCAAGTGCCCCATTTGCTCCAAGTCTGTGGCTTCTGACGAGA
TGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGGAAGAATACAAAGAAGCCTCAGAGGGGCTCAGCCTGAGA
AAACCTGGCTCTCAGGAAGAACTTTGCAAGAGCAGCCGTGGAGGACAGAGTGCTCTTGGGCCCCCATGGCCCAAATGCAGAGTTACCCCC
ACTGCCCTGTGGAGAACCGGGAAGATGATGTGCTGACTAAAGACGCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACA
CGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGCTGCATAGACTCGTGGTTTGAAGTGAACAGATCTTGTCCGGAACACCCTG
CGGACTGACCTGCGGGCTTGCTTGCTGACTCCTCTCAAAGGGACAGAGCGCCCCTGCTCCAGGGAGGAGGCTCACCGGACCCTGGGGCAG
AGCTGAGCTTGGGACACCAGCGGGAACAGGGCACCCCTTCTGCACTGACTTCCAGATCATGGTTCTCCCTTCCTCCCTGAGGACACCAAA
TTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTATCCTTCCCCTCACCCCTCAGCCCAGGAGGGAAAGGGCATTTTCTTTTT
CATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAAGTGTTTACAAAAAAAAATTATATAAAAAAAAAGTCTAGTGTCGACTGGTGTTTTCC
CTCGTGATGTTTACAGCTTGCTGTTTGCTGCCCAGCCATAACCCACTCAGTGACAGACGAACACAGCTAAGGCCTCGCTGCCAGCCTTCT
GACGGCGGGCGAGCACACGGTCTCTTCCCCTGCCCCAACTGGCCCTCTCCACCACCAACTTCTCTACTTTGGGTTTGTTTGGTTTTTTCC
CTCTATTTTTCTGGCTGGTTTTTTGCTCTTTTCTCCCCTTGAGACCCTAATATCTTGACTTCATTGCCAAAAAACAACCCATTGAGAACT
TTCTTCCTACTGATCCCATCTCTTTTCCCTTCTTTCCTCCTGGTTCCGGTCAGTTCAGAGGATTTAACAATCACAAGTGTCCTGCAAAAA
TGCCTGAACATTATTCTTAGGCCCTCGTGGATTTTTTTTTTCAGAAAACTTAAACAAAAAAAGACTTACTAAGAAATATGTACAGCTACC
CCTGTTTTCAGGCACTATGTTTGAGAACATTTTAGCCATTGATGTTCACACGTGGCATCAGCCCATGCAAGATAGGTTTCTGTATTTATA
TATTAAAATACAAAAAAAAACTTATAAAATGTTTAAAAAAATGTTCAAAGCTTGGGAGAAAAGCTTTCTTCATTAGTCAAGGTGTTTTGA

>95660_95660_1_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000525621_ZNRF1_chr16_75127469_ENST00000320619_length(amino acids)=201AA_BP=64
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGFKCPICSKSVASDEMEMHFIMCLSK
PRLSYNGRIQRSLRGAQPEKTWLSGRTLQEQPWRTECSWAPMAQMQSYPHCPVENREDDVLTKDAGECVICLEELLQGDTIARLPCLCIY

--------------------------------------------------------------
>95660_95660_2_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000525621_ZNRF1_chr16_75127469_ENST00000335325_length(transcript)=4229nt_BP=675nt
AAAAAAAAAAAAATCCAATGGTGACGAGCAGGGAGAACAGAGCAGCTGCCAATGGGCGTGTGCGTTTCAGGCGGCCAATGGGAGGAGGCG
TCTCGGCGGGGGACAAGCAGTAGCTACCCGCGGGAGCGGGGAGGGGTCCGGGTTCGAGCTTGTGTTCCCCCGGAAGGGTGAGTCTGGACG
CGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCTTGACAGGCTGCACTTGGATGGGAGCACCT
GGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATATTGAAACATTACAACCATCTTTTGATGGC
AACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGCTTGCTTGAGTTGACACAGGGAGCTCCAGG
ACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCC
AGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCAT
CGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGGTTTCAAGTGCCCCATTTGCTCCAAGTCTGTGGCTTCTGACGAGA
TGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCTGACTAAAGACGCGGGTGAGTGTGTGATCT
GCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGCTGCATAGACTCGTGGTTTGAAG
TGAACAGATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTCTCAAAGGGACAGAGCGCCCCTGCTCCAGG
GAGGAGGCTCACCGGACCCTGGGGCAGAGCTGAGCTTGGGACACCAGCGGGAACAGGGCACCCCTTCTGCACTGACTTCCAGATCATGGT
TCTCCCTTCCTCCCTGAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTATCCTTCCCCTCACCCCTCAGC
CCAGGAGGGAAAGGGCATTTTCTTTTTCATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAAGTGTTTACAAAAAAAAATTATATAAAAAA
AAAGTCTAGTGTCGACTGGTGTTTTCCCTCGTGATGTTTACAGCTTGCTGTTTGCTGCCCAGCCATAACCCACTCAGTGACAGACGAACA
CAGCTAAGGCCTCGCTGCCAGCCTTCTGACGGCGGGCGAGCACACGGTCTCTTCCCCTGCCCCAACTGGCCCTCTCCACCACCAACTTCT
CTACTTTGGGTTTGTTTGGTTTTTTCCCTCTATTTTTCTGGCTGGTTTTTTGCTCTTTTCTCCCCTTGAGACCCTAATATCTTGACTTCA
TTGCCAAAAAACAACCCATTGAGAACTTTCTTCCTACTGATCCCATCTCTTTTCCCTTCTTTCCTCCTGGTTCCGGTCAGTTCAGAGGAT
TTAACAATCACAAGTGTCCTGCAAAAATGCCTGAACATTATTCTTAGGCCCTCGTGGATTTTTTTTTTCAGAAAACTTAAACAAAAAAAG
ACTTACTAAGAAATATGTACAGCTACCCCTGTTTTCAGGCACTATGTTTGAGAACATTTTAGCCATTGATGTTCACACGTGGCATCAGCC
CATGCAAGATAGGTTTCTGTATTTATATATTAAAATACAAAAAAAAACTTATAAAATGTTTAAAAAAATGTTCAAAGCTTGGGAGAAAAG
CTTTCTTCATTAGTCAAGGTGTTTTGATATGGTATTAAAATGTCTAATAAAAGATGGCACTGCGTGATTTTATTTTAATGAAGTGTTATA
CAATCAAGAAATGGGGGCAAGGGCCTGCCCCCCACTCCCTCACCTACCTCCTTAGCATTCCTTCAGGCTGCTACTCGGGGCTCCAGGTGT
GTGAATTGGTCCTCAGATAGTCAGGCCTGGGTGGAGGGAGTGGCAAGTCAGGCGTGCCTCCTACAAGCTTCCTAACCTCTTAAGCATCAT
GGAACCAGTCAGCCCTCTGTGGAGTCATTGTGCTGGACCTCTGAAAAGATCTGCAGGGGCCAAGATGTTGCAGCCACCGGAGGCTGCAAG
GATGTGGGTTCTTCCAGGTGTGGGCCCAGCCCCCCTCCTTCCAGCCTTTGCTCCCCATCCCACGTTCCACTCGCCCTGCCTGTTGTTCAG
TTTGCGTCTCAGTGCTGACTCACGGGCATGCTTCATTGAGGCCCAGGAAGAGGCCCTGGTTTGGGGCTGTGCCAGCTCAGAGCCCTTGAA
CCAGAACCAACTGCTCAGGCTCACAAAAGTTGGCAAAATGCGGGCTGGGCAGGCAGCTCGGGGCAGGGAGCAGCAGTGCAGGCCTGGCCT
GTGTCCCCGTGCCCAGCGGGCTCCCGGAGCAGCATTCCAGAGCCTCCTGCAGAGCCAGCGAAGGAAAGCTCTAGAGGGAGACGACTCCAC
CGCCTCTCTGCTCTGACCCTTCTCAGGCCCGCCTGATGTGCTGGACCATCCCCCTGCTGCCACGGCCCCTGGCTCCGCAGTCACCCTCCA
TCAGATGCTTCCAGAAGCACCTACTCTGTGCAAGGGCATTCACAACAGGCCAGTGGGCAAACGTGAGCCAGGGCCAGCGGAGAAACACTA
AAGAAGACTCGGTGGTTCAGAGCCTGGGTCTCAGCGCGGGACCCGTCTGGGGTGAAGACCTTGGGGCTGTTGTGAGTCGGTGGCAGGAAC
GTGGGCTCTAGACTGTGCATTCAGGCTCTCCTACTTGGCAGAATGATCTTGGGGAAACGACTTCATCTGAACTTCAGATATTTCACATGT
GAAGCGGGGACAAAACCATGCAGCTCAGAGGTCCCTGTGGGGGCTGGGGGAGCTGCCCTGCAGGTCTTGGCACATGCACAGCAGGCTCCC
CATAGCTTTGTCACCACAAAGGGCACTGTTCTATTCACAGCACCTCCTGCTTCTGCCTGGCAACTGTGTCTCCCTGTGCTATATTTAATT
CCACCAGCAAAGCTGGCGAGGCAGGGCCCAGCCCTGAAGGAGATCTCCTTGCCTGACCCCTGGACCTGGAAATGGAGGCTTCATGTGCCC
GCCTTGGCGGCTTAAGCCTGCTGCTTTGGCAGTGCCATGGGTGAGCCGAGCAGCTGTGAGGTGGGTGGGGCAGGGCTGTAGCCCACGCCG
GGTGCTATTCCAGGCTCTAGGGGCTGGTGCTCATCCCCACCCCCAGCGACTTCCGTCCTACCTGGCATGCTGCAGCCCTCTGCCGGCTGT
GGTGTCCTCTGAATTTGGACCCAGGTTGCCTGCTCTTGTTGTGGGGGTGGGATTGGGGCTGTCTGTGTTTCCCAGGTGGAGCTCATGTTT
GTGATCCTCTATCTGGACAGCTCTCCAGAATCCTGTGTTGCCCCTGTTCTGCCTTTCTGGGATGGGAGAGAAGGTGAGGGAGCCGGCGAG
CAGGTTCTACCCTCTCTGCTAAGGGCCTAGCACACTTTGATGAGGTTCCTGGACGTGAGACCCTCACAAAGACCAACCATTCCTCTAATA
GCCATTTAACGGTACTGCAGTTCATGGGAAAATGTCCTCATTCTTAGGAGATAGATGCTGGATTATATAGGTGAATGCCTTCAAGAAATG
TGTAATTTAATTCCAAATAGTTCCCCCCAAAATACACAAAGCAAATAAGGCCAAAATGTTCATTGTTGAATCTGCAGTGGCTGGTATTTC
AGTGAACAGTGTACTTGTTCTTTCAACTTTTCTGTATGTTTGGAATTTTTCTTAATAAAAGATTGTGGGAAATGGTCATTTGCTGAGCGC
CTCCTAGTTGCCAGGCACTGGAGGGCGCATCAAAGAAGAGTCCTACCCAGGAGGGAGAGCGCAGCTGCTGCAGGATTCTCGCCTGGAAGA
GTGGGTGGCTGGCTGGCTGGCTGGAAGGGGAGGGGCGAGAGGGCTGTCTCGGTGATGAGCACACGCGTGCTGGGGTGGTTTGGGGAGAGG

>95660_95660_2_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000525621_ZNRF1_chr16_75127469_ENST00000335325_length(amino acids)=155AA_BP=
MEPVSPLWSHCAGPLKRSAGAKMLQPPEAARMWVLPGVGPAPLLPAFAPHPTFHSPCLLFSLRLSADSRACFIEAQEEALVWGCASSEPL

--------------------------------------------------------------
>95660_95660_3_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000525621_ZNRF1_chr16_75127469_ENST00000566250_length(transcript)=993nt_BP=675nt
AAAAAAAAAAAAATCCAATGGTGACGAGCAGGGAGAACAGAGCAGCTGCCAATGGGCGTGTGCGTTTCAGGCGGCCAATGGGAGGAGGCG
TCTCGGCGGGGGACAAGCAGTAGCTACCCGCGGGAGCGGGGAGGGGTCCGGGTTCGAGCTTGTGTTCCCCCGGAAGGGTGAGTCTGGACG
CGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCTTGACAGGCTGCACTTGGATGGGAGCACCT
GGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATATTGAAACATTACAACCATCTTTTGATGGC
AACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGCTTGCTTGAGTTGACACAGGGAGCTCCAGG
ACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCC
AGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCAT
CGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGGTTTCAAGTGCCCCATTTGCTCCAAGTCTGTGGCTTCTGACGAGA
TGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCTGACTAAAGACGCGGGTGAGTGTGTGATCT
GCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGGTAGGAGGGGTTGGCAAGGTAGC
TTAGTGCACCCCACCTCCCAGAGGGGCGGACCCCCATCTCCAGCCATTCTGTCTCCTTTGGTTATGGGATGACCTCTCCCCCGACCTCTG

>95660_95660_3_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000525621_ZNRF1_chr16_75127469_ENST00000566250_length(amino acids)=132AA_BP=64
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGFKCPICSKSVASDEMEMHFIMCLSK

--------------------------------------------------------------
>95660_95660_4_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000525621_ZNRF1_chr16_75127469_ENST00000567962_length(transcript)=1158nt_BP=675nt
AAAAAAAAAAAAATCCAATGGTGACGAGCAGGGAGAACAGAGCAGCTGCCAATGGGCGTGTGCGTTTCAGGCGGCCAATGGGAGGAGGCG
TCTCGGCGGGGGACAAGCAGTAGCTACCCGCGGGAGCGGGGAGGGGTCCGGGTTCGAGCTTGTGTTCCCCCGGAAGGGTGAGTCTGGACG
CGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCTTGACAGGCTGCACTTGGATGGGAGCACCT
GGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATATTGAAACATTACAACCATCTTTTGATGGC
AACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGCTTGCTTGAGTTGACACAGGGAGCTCCAGG
ACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAGGGGCAGTAAGCCCGTTGGGGATGGAGCCC
AGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGGGGAGCCCTGGGTCACTTTCAGTGAGTCAT
CGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGGTTTCAAGTGCCCCATTTGCTCCAAGTCTGTGGCTTCTGACGAGA
TGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCTGACTAAAGACGCGGGTGAGTGTGTGATCT
GCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGCTGCATAGACTCGTGGTTTGAAG
TGAACAGATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTCTCAAAGATCATGGTTCTCCCTTCCTCCCT
GAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTATCCTTCCCCTCACCCCTCAGCCCAGGAGGGAAAGGG

>95660_95660_4_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000525621_ZNRF1_chr16_75127469_ENST00000567962_length(amino acids)=150AA_BP=64
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGFKCPICSKSVASDEMEMHFIMCLSK

--------------------------------------------------------------
>95660_95660_5_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000529370_ZNRF1_chr16_75127469_ENST00000320619_length(transcript)=1944nt_BP=524nt
GTGTTCCCCCGGAAGGGTGAGTCTGGACGCGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCT
TGACAGGCTGCACTTGGATGGGAGCACCTGGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATA
TTGAAACATTACAACCATCTTTTGATGGCAACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGC
TTGCTTGAGTTGACACAGGGAGCTCCAGGACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAG
GGGCAGTAAGCCCGTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGG
GGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGGTTTCAAGTGCCCCAT
TTGCTCCAAGTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGGAAGAATACA
AAGAAGCCTCAGAGGGGCTCAGCCTGAGAAAACCTGGCTCTCAGGAAGAACTTTGCAAGAGCAGCCGTGGAGGACAGAGTGCTCTTGGGC
CCCCATGGCCCAAATGCAGAGTTACCCCCACTGCCCTGTGGAGAACCGGGAAGATGATGTGCTGACTAAAGACGCGGGTGAGTGTGTGAT
CTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCACAAAAGCTGCATAGACTCGTGGTTTGA
AGTGAACAGATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTCTCAAAGGGACAGAGCGCCCCTGCTCCA
GGGAGGAGGCTCACCGGACCCTGGGGCAGAGCTGAGCTTGGGACACCAGCGGGAACAGGGCACCCCTTCTGCACTGACTTCCAGATCATG
GTTCTCCCTTCCTCCCTGAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTATCCTTCCCCTCACCCCTCA
GCCCAGGAGGGAAAGGGCATTTTCTTTTTCATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAAGTGTTTACAAAAAAAAATTATATAAAA
AAAAAGTCTAGTGTCGACTGGTGTTTTCCCTCGTGATGTTTACAGCTTGCTGTTTGCTGCCCAGCCATAACCCACTCAGTGACAGACGAA
CACAGCTAAGGCCTCGCTGCCAGCCTTCTGACGGCGGGCGAGCACACGGTCTCTTCCCCTGCCCCAACTGGCCCTCTCCACCACCAACTT
CTCTACTTTGGGTTTGTTTGGTTTTTTCCCTCTATTTTTCTGGCTGGTTTTTTGCTCTTTTCTCCCCTTGAGACCCTAATATCTTGACTT
CATTGCCAAAAAACAACCCATTGAGAACTTTCTTCCTACTGATCCCATCTCTTTTCCCTTCTTTCCTCCTGGTTCCGGTCAGTTCAGAGG
ATTTAACAATCACAAGTGTCCTGCAAAAATGCCTGAACATTATTCTTAGGCCCTCGTGGATTTTTTTTTTCAGAAAACTTAAACAAAAAA
AGACTTACTAAGAAATATGTACAGCTACCCCTGTTTTCAGGCACTATGTTTGAGAACATTTTAGCCATTGATGTTCACACGTGGCATCAG
CCCATGCAAGATAGGTTTCTGTATTTATATATTAAAATACAAAAAAAAACTTATAAAATGTTTAAAAAAATGTTCAAAGCTTGGGAGAAA

>95660_95660_5_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000529370_ZNRF1_chr16_75127469_ENST00000320619_length(amino acids)=201AA_BP=64
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGFKCPICSKSVASDEMEMHFIMCLSK
PRLSYNGRIQRSLRGAQPEKTWLSGRTLQEQPWRTECSWAPMAQMQSYPHCPVENREDDVLTKDAGECVICLEELLQGDTIARLPCLCIY

--------------------------------------------------------------
>95660_95660_6_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000529370_ZNRF1_chr16_75127469_ENST00000335325_length(transcript)=4078nt_BP=524nt
GTGTTCCCCCGGAAGGGTGAGTCTGGACGCGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCT
TGACAGGCTGCACTTGGATGGGAGCACCTGGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATA
TTGAAACATTACAACCATCTTTTGATGGCAACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGC
TTGCTTGAGTTGACACAGGGAGCTCCAGGACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAG
GGGCAGTAAGCCCGTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGG
GGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGGTTTCAAGTGCCCCAT
TTGCTCCAAGTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCT
GACTAAAGACGCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCA
CAAAAGCTGCATAGACTCGTGGTTTGAAGTGAACAGATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTC
TCAAAGGGACAGAGCGCCCCTGCTCCAGGGAGGAGGCTCACCGGACCCTGGGGCAGAGCTGAGCTTGGGACACCAGCGGGAACAGGGCAC
CCCTTCTGCACTGACTTCCAGATCATGGTTCTCCCTTCCTCCCTGAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATC
AACTGCTATCCTTCCCCTCACCCCTCAGCCCAGGAGGGAAAGGGCATTTTCTTTTTCATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAA
GTGTTTACAAAAAAAAATTATATAAAAAAAAAGTCTAGTGTCGACTGGTGTTTTCCCTCGTGATGTTTACAGCTTGCTGTTTGCTGCCCA
GCCATAACCCACTCAGTGACAGACGAACACAGCTAAGGCCTCGCTGCCAGCCTTCTGACGGCGGGCGAGCACACGGTCTCTTCCCCTGCC
CCAACTGGCCCTCTCCACCACCAACTTCTCTACTTTGGGTTTGTTTGGTTTTTTCCCTCTATTTTTCTGGCTGGTTTTTTGCTCTTTTCT
CCCCTTGAGACCCTAATATCTTGACTTCATTGCCAAAAAACAACCCATTGAGAACTTTCTTCCTACTGATCCCATCTCTTTTCCCTTCTT
TCCTCCTGGTTCCGGTCAGTTCAGAGGATTTAACAATCACAAGTGTCCTGCAAAAATGCCTGAACATTATTCTTAGGCCCTCGTGGATTT
TTTTTTTCAGAAAACTTAAACAAAAAAAGACTTACTAAGAAATATGTACAGCTACCCCTGTTTTCAGGCACTATGTTTGAGAACATTTTA
GCCATTGATGTTCACACGTGGCATCAGCCCATGCAAGATAGGTTTCTGTATTTATATATTAAAATACAAAAAAAAACTTATAAAATGTTT
AAAAAAATGTTCAAAGCTTGGGAGAAAAGCTTTCTTCATTAGTCAAGGTGTTTTGATATGGTATTAAAATGTCTAATAAAAGATGGCACT
GCGTGATTTTATTTTAATGAAGTGTTATACAATCAAGAAATGGGGGCAAGGGCCTGCCCCCCACTCCCTCACCTACCTCCTTAGCATTCC
TTCAGGCTGCTACTCGGGGCTCCAGGTGTGTGAATTGGTCCTCAGATAGTCAGGCCTGGGTGGAGGGAGTGGCAAGTCAGGCGTGCCTCC
TACAAGCTTCCTAACCTCTTAAGCATCATGGAACCAGTCAGCCCTCTGTGGAGTCATTGTGCTGGACCTCTGAAAAGATCTGCAGGGGCC
AAGATGTTGCAGCCACCGGAGGCTGCAAGGATGTGGGTTCTTCCAGGTGTGGGCCCAGCCCCCCTCCTTCCAGCCTTTGCTCCCCATCCC
ACGTTCCACTCGCCCTGCCTGTTGTTCAGTTTGCGTCTCAGTGCTGACTCACGGGCATGCTTCATTGAGGCCCAGGAAGAGGCCCTGGTT
TGGGGCTGTGCCAGCTCAGAGCCCTTGAACCAGAACCAACTGCTCAGGCTCACAAAAGTTGGCAAAATGCGGGCTGGGCAGGCAGCTCGG
GGCAGGGAGCAGCAGTGCAGGCCTGGCCTGTGTCCCCGTGCCCAGCGGGCTCCCGGAGCAGCATTCCAGAGCCTCCTGCAGAGCCAGCGA
AGGAAAGCTCTAGAGGGAGACGACTCCACCGCCTCTCTGCTCTGACCCTTCTCAGGCCCGCCTGATGTGCTGGACCATCCCCCTGCTGCC
ACGGCCCCTGGCTCCGCAGTCACCCTCCATCAGATGCTTCCAGAAGCACCTACTCTGTGCAAGGGCATTCACAACAGGCCAGTGGGCAAA
CGTGAGCCAGGGCCAGCGGAGAAACACTAAAGAAGACTCGGTGGTTCAGAGCCTGGGTCTCAGCGCGGGACCCGTCTGGGGTGAAGACCT
TGGGGCTGTTGTGAGTCGGTGGCAGGAACGTGGGCTCTAGACTGTGCATTCAGGCTCTCCTACTTGGCAGAATGATCTTGGGGAAACGAC
TTCATCTGAACTTCAGATATTTCACATGTGAAGCGGGGACAAAACCATGCAGCTCAGAGGTCCCTGTGGGGGCTGGGGGAGCTGCCCTGC
AGGTCTTGGCACATGCACAGCAGGCTCCCCATAGCTTTGTCACCACAAAGGGCACTGTTCTATTCACAGCACCTCCTGCTTCTGCCTGGC
AACTGTGTCTCCCTGTGCTATATTTAATTCCACCAGCAAAGCTGGCGAGGCAGGGCCCAGCCCTGAAGGAGATCTCCTTGCCTGACCCCT
GGACCTGGAAATGGAGGCTTCATGTGCCCGCCTTGGCGGCTTAAGCCTGCTGCTTTGGCAGTGCCATGGGTGAGCCGAGCAGCTGTGAGG
TGGGTGGGGCAGGGCTGTAGCCCACGCCGGGTGCTATTCCAGGCTCTAGGGGCTGGTGCTCATCCCCACCCCCAGCGACTTCCGTCCTAC
CTGGCATGCTGCAGCCCTCTGCCGGCTGTGGTGTCCTCTGAATTTGGACCCAGGTTGCCTGCTCTTGTTGTGGGGGTGGGATTGGGGCTG
TCTGTGTTTCCCAGGTGGAGCTCATGTTTGTGATCCTCTATCTGGACAGCTCTCCAGAATCCTGTGTTGCCCCTGTTCTGCCTTTCTGGG
ATGGGAGAGAAGGTGAGGGAGCCGGCGAGCAGGTTCTACCCTCTCTGCTAAGGGCCTAGCACACTTTGATGAGGTTCCTGGACGTGAGAC
CCTCACAAAGACCAACCATTCCTCTAATAGCCATTTAACGGTACTGCAGTTCATGGGAAAATGTCCTCATTCTTAGGAGATAGATGCTGG
ATTATATAGGTGAATGCCTTCAAGAAATGTGTAATTTAATTCCAAATAGTTCCCCCCAAAATACACAAAGCAAATAAGGCCAAAATGTTC
ATTGTTGAATCTGCAGTGGCTGGTATTTCAGTGAACAGTGTACTTGTTCTTTCAACTTTTCTGTATGTTTGGAATTTTTCTTAATAAAAG
ATTGTGGGAAATGGTCATTTGCTGAGCGCCTCCTAGTTGCCAGGCACTGGAGGGCGCATCAAAGAAGAGTCCTACCCAGGAGGGAGAGCG
CAGCTGCTGCAGGATTCTCGCCTGGAAGAGTGGGTGGCTGGCTGGCTGGCTGGAAGGGGAGGGGCGAGAGGGCTGTCTCGGTGATGAGCA
CACGCGTGCTGGGGTGGTTTGGGGAGAGGGCTGAGATTTGTCACCAGTGAGCCCTTGGCACGGTCTCTGCTCCCCACCAGGGCAGCACGG

>95660_95660_6_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000529370_ZNRF1_chr16_75127469_ENST00000335325_length(amino acids)=155AA_BP=
MEPVSPLWSHCAGPLKRSAGAKMLQPPEAARMWVLPGVGPAPLLPAFAPHPTFHSPCLLFSLRLSADSRACFIEAQEEALVWGCASSEPL

--------------------------------------------------------------
>95660_95660_7_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000529370_ZNRF1_chr16_75127469_ENST00000566250_length(transcript)=842nt_BP=524nt
GTGTTCCCCCGGAAGGGTGAGTCTGGACGCGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCT
TGACAGGCTGCACTTGGATGGGAGCACCTGGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATA
TTGAAACATTACAACCATCTTTTGATGGCAACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGC
TTGCTTGAGTTGACACAGGGAGCTCCAGGACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAG
GGGCAGTAAGCCCGTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGG
GGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGGTTTCAAGTGCCCCAT
TTGCTCCAAGTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCT
GACTAAAGACGCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCA
CAAAAGGTAGGAGGGGTTGGCAAGGTAGCTTAGTGCACCCCACCTCCCAGAGGGGCGGACCCCCATCTCCAGCCATTCTGTCTCCTTTGG

>95660_95660_7_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000529370_ZNRF1_chr16_75127469_ENST00000566250_length(amino acids)=132AA_BP=64
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGFKCPICSKSVASDEMEMHFIMCLSK

--------------------------------------------------------------
>95660_95660_8_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000529370_ZNRF1_chr16_75127469_ENST00000567962_length(transcript)=1007nt_BP=524nt
GTGTTCCCCCGGAAGGGTGAGTCTGGACGCGGGCGCGGAAGGAGCGCGGCCGGAGGTCCTCAGGAAGAAGCCGCGGGGACTGGCTGCGCT
TGACAGGCTGCACTTGGATGGGAGCACCTGGTGCCTCGGGACTGCTCCGATGCCCGGGTCTGTGCTGAATGTGTAATATGCGGAACTATA
TTGAAACATTACAACCATCTTTTGATGGCAACACCCTGAGGACCTCCCTTTTCCAGATGGGGAAACTGAGGCCCAGAATTGCTAAGTGGC
TTGCTTGAGTTGACACAGGGAGCTCCAGGACTCACCCTCAGCTGAGCCACCTGCCGGGAGCATGCCTCTGCGCCACTGGGGGATGGCCAG
GGGCAGTAAGCCCGTTGGGGATGGAGCCCAGCCCATGGCTGCCATGGGAGGCCTGAAGGTGCTTCTGCACTGGGCTGGTCCAGGCGGCGG
GGAGCCCTGGGTCACTTTCAGTGAGTCATCGCTGACAGCTGAGGAAGTCTGCATCCACATTGCACATAAAGTTGGTTTCAAGTGCCCCAT
TTGCTCCAAGTCTGTGGCTTCTGACGAGATGGAAATGCACTTTATAATGTGTTTGAGCAAACCTCGCCTCTCCTACAACGATGATGTGCT
GACTAAAGACGCGGGTGAGTGTGTGATCTGCCTGGAGGAGCTGCTGCAGGGGGACACGATAGCCAGGCTGCCCTGCCTGTGCATCTATCA
CAAAAGCTGCATAGACTCGTGGTTTGAAGTGAACAGATCTTGTCCGGAACACCCTGCGGACTGACCTGCGGGCTTGCTTGCTGACTCCTC
TCAAAGATCATGGTTCTCCCTTCCTCCCTGAGGACACCAAATTGGATGAGAGCAAGTTTGAGAGAAGAATGAATCAACTGCTATCCTTCC
CCTCACCCCTCAGCCCAGGAGGGAAAGGGCATTTTCTTTTTCATCTTTGAAAGGCATTGTGGGTCTGTCTTTAAAGTGTTTACAAAAAAA

>95660_95660_8_TYK2-ZNRF1_TYK2_chr19_10488889_ENST00000529370_ZNRF1_chr16_75127469_ENST00000567962_length(amino acids)=150AA_BP=64
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGFKCPICSKSVASDEMEMHFIMCLSK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TYK2-ZNRF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TYK2-ZNRF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TYK2-ZNRF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource