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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TYMS-ENOSF1 (FusionGDB2 ID:95670)

Fusion Gene Summary for TYMS-ENOSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: TYMS-ENOSF1
Fusion gene ID: 95670
HgeneTgene
Gene symbol

TYMS

ENOSF1

Gene ID

7298

55556

Gene namethymidylate synthetaseenolase superfamily member 1
SynonymsHST422|TMS|TSFUCD|RTS|TYMSAS
Cytomap

18p11.32

18p11.32

Type of geneprotein-codingprotein-coding
Descriptionthymidylate synthaseTSasemitochondrial enolase superfamily member 1L-fuconate dehydrataseantisense RNA to thymidylate synthase
Modification date2020032220200313
UniProtAcc

TYMSOS,C18orf56

Q7L5Y1

Ensembl transtripts involved in fusion geneENST00000581920, ENST00000323250, 
ENST00000323274, ENST00000323224, 
ENST00000251101, ENST00000319815, 
ENST00000340116, ENST00000383578, 
ENST00000539164, ENST00000580982, 
ENST00000583973, 
Fusion gene scores* DoF score13 X 7 X 9=8195 X 5 X 2=50
# samples 135
** MAII scorelog2(13/819*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: TYMS [Title/Abstract] AND ENOSF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTYMS(669173)-ENOSF1(670692), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTYMS

GO:0006231

dTMP biosynthetic process

8845352|11278511|15093541

HgeneTYMS

GO:0017148

negative regulation of translation

1924359

HgeneTYMS

GO:0035999

tetrahydrofolate interconversion

15093541

TgeneENOSF1

GO:0044275

cellular carbohydrate catabolic process

24697329


check buttonFusion gene breakpoints across TYMS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ENOSF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF245161TYMSchr18

669173

+ENOSF1chr18

670692

+


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Fusion Gene ORF analysis for TYMS-ENOSF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000581920ENST00000251101TYMSchr18

669173

+ENOSF1chr18

670692

+
3UTR-intronENST00000581920ENST00000319815TYMSchr18

669173

+ENOSF1chr18

670692

+
3UTR-intronENST00000581920ENST00000340116TYMSchr18

669173

+ENOSF1chr18

670692

+
3UTR-intronENST00000581920ENST00000383578TYMSchr18

669173

+ENOSF1chr18

670692

+
3UTR-intronENST00000581920ENST00000539164TYMSchr18

669173

+ENOSF1chr18

670692

+
3UTR-intronENST00000581920ENST00000580982TYMSchr18

669173

+ENOSF1chr18

670692

+
3UTR-intronENST00000581920ENST00000583973TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323250ENST00000251101TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323250ENST00000319815TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323250ENST00000340116TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323250ENST00000383578TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323250ENST00000539164TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323250ENST00000580982TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323250ENST00000583973TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323274ENST00000251101TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323274ENST00000319815TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323274ENST00000340116TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323274ENST00000383578TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323274ENST00000539164TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323274ENST00000580982TYMSchr18

669173

+ENOSF1chr18

670692

+
5CDS-intronENST00000323274ENST00000583973TYMSchr18

669173

+ENOSF1chr18

670692

+
intron-intronENST00000323224ENST00000251101TYMSchr18

669173

+ENOSF1chr18

670692

+
intron-intronENST00000323224ENST00000319815TYMSchr18

669173

+ENOSF1chr18

670692

+
intron-intronENST00000323224ENST00000340116TYMSchr18

669173

+ENOSF1chr18

670692

+
intron-intronENST00000323224ENST00000383578TYMSchr18

669173

+ENOSF1chr18

670692

+
intron-intronENST00000323224ENST00000539164TYMSchr18

669173

+ENOSF1chr18

670692

+
intron-intronENST00000323224ENST00000580982TYMSchr18

669173

+ENOSF1chr18

670692

+
intron-intronENST00000323224ENST00000583973TYMSchr18

669173

+ENOSF1chr18

670692

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TYMS-ENOSF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TYMS-ENOSF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:669173/:670692)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TYMS

TYMSOS,C18orf56

ENOSF1

Q7L5Y1

123FUNCTION: Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329). {ECO:0000269|PubMed:24697329}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TYMS-ENOSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TYMS-ENOSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TYMS-ENOSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TYMS-ENOSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource