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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BDP1-KDM5A (FusionGDB2 ID:9568)

Fusion Gene Summary for BDP1-KDM5A

Fusion gene summary

Fusion gene information	Fusion gene name: BDP1-KDM5A
	Fusion gene ID: 9568
		Hgene	Tgene
	Gene symbol	BDP1	KDM5A
	Gene ID	55814	5927
	Gene name	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	lysine demethylase 5A
	Synonyms	DFNB112\|HSA238520\|TAF3B1\|TFC5\|TFIIIB''\|TFIIIB150\|TFIIIB90\|TFNR	RBBP-2\|RBBP2\|RBP2
	Cytomap	5q13.2	12p13.33
	Type of gene	protein-coding	protein-coding
	Description	transcription factor TFIIIB component B'' homologRNA polymerase III transcription initiation factor B''TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 1transcription factor IIIB 150transcription factor-like nuclear	lysine-specific demethylase 5AJumonji, AT rich interactive domain 1A (RBP2-like)histone demethylase JARID1Ajumonji/ARID domain-containing protein 1Alysine (K)-specific demethylase 5Aretinoblastoma binding protein 2
	Modification date	20200313	20200313
	UniProtAcc	A6H8Y1	P29375
	Ensembl transtripts involved in fusion gene	ENST00000358731, ENST00000380675,	ENST00000382815, ENST00000540838, ENST00000399788,
Fusion gene scores	* DoF score	8 X 8 X 5=320	10 X 11 X 4=440
	# samples	9	10
	** MAII score	log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/440*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BDP1 [Title/Abstract] AND KDM5A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BDP1(70811993)-KDM5A(402303), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KDM5A	GO:0034720	histone H3-K4 demethylation	18270511
Tgene	KDM5A	GO:0045893	positive regulation of transcription, DNA-templated	11358960

Fusion gene breakpoints across BDP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KDM5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CB119428	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-
ChiTaRS5.0	N/A	CB119529	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-

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Fusion Gene ORF analysis for BDP1-KDM5A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000358731	ENST00000382815	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-
5CDS-intron	ENST00000358731	ENST00000540838	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-
5UTR-3CDS	ENST00000380675	ENST00000399788	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-
5UTR-intron	ENST00000380675	ENST00000382815	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-
5UTR-intron	ENST00000380675	ENST00000540838	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-
In-frame	ENST00000358731	ENST00000399788	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000358731

BDP1

chr5

70811993

ENST00000399788

KDM5A

chr12

402303

10930

5017

263

4930

1555

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000358731	ENST00000399788	BDP1	chr5	70811993	+	KDM5A	chr12	402303	-	0.000142348	0.99985766

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Fusion Genomic Features for BDP1-KDM5A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BDP1-KDM5A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:70811993/chr12:402303)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BDP1 A6H8Y1	KDM5A P29375
FUNCTION: General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site. {ECO:0000269\|PubMed:11040218}.	FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228). {ECO:0000250\|UniProtKB:Q3UXZ9, ECO:0000269\|PubMed:11358960, ECO:0000269\|PubMed:15949438, ECO:0000269\|PubMed:17320160, ECO:0000269\|PubMed:17320161, ECO:0000269\|PubMed:17320163, ECO:0000269\|PubMed:18270511, ECO:0000269\|PubMed:19430464, ECO:0000269\|PubMed:27427228}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

1492_1587

1691.0

Compositional bias

Note=Lys-rich

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

19_60

1691.0

Domain

JmjN

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

437_603

1691.0

Domain

JmjC

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

84_174

1691.0

Domain

ARID

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

419_423

1691.0

Motif

GSGFP motif

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

1161_1218

1691.0

Zinc finger

PHD-type 2

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

1607_1661

1691.0

Zinc finger

PHD-type 3

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

293_343

1691.0

Zinc finger

PHD-type 1

Tgene

KDM5A

chr5:70811993

chr12:402303

ENST00000399788

676_728

1691.0

Zinc finger

C5HC2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1078_1103

2625.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1223_1284

2625.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

144_177

2625.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1078_1103

1360.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1223_1284

1360.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

144_177

1360.6666666666667

Coiled coil

Ontology_term=ECO:0000255

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

84_119

2625.0

Compositional bias

Note=Ser-rich

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

84_119

1360.6666666666667

Compositional bias

Note=Ser-rich

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

295_345

2625.0

Domain

Note=Myb-like

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

295_345

1360.6666666666667

Domain

Note=Myb-like

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

355_470

2625.0

Region

Note=Required for phosphorylation by CSNK2A1

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

823_1327

2625.0

Region

Note=9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N-G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R-E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X-D-L-E-E-T

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

355_470

1360.6666666666667

Region

Note=Required for phosphorylation by CSNK2A1

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

823_1327

1360.6666666666667

Region

Note=9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N-G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R-E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X-D-L-E-E-T

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1041_1094

2625.0

Repeat

Note=5

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1095_1148

2625.0

Repeat

Note=6

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1149_1203

2625.0

Repeat

Note=7

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1204_1257

2625.0

Repeat

Note=8%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

1258_1327

2625.0

Repeat

Note=9%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

823_877

2625.0

Repeat

Note=1%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

878_932

2625.0

Repeat

Note=2

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

933_987

2625.0

Repeat

Note=3

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000358731

988_1040

2625.0

Repeat

Note=4

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1041_1094

1360.6666666666667

Repeat

Note=5

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1095_1148

1360.6666666666667

Repeat

Note=6

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1149_1203

1360.6666666666667

Repeat

Note=7

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1204_1257

1360.6666666666667

Repeat

Note=8%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

1258_1327

1360.6666666666667

Repeat

Note=9%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

823_877

1360.6666666666667

Repeat

Note=1%3B approximate

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

878_932

1360.6666666666667

Repeat

Note=2

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

933_987

1360.6666666666667

Repeat

Note=3

Hgene

BDP1

chr5:70811993

chr12:402303

ENST00000380675

988_1040

1360.6666666666667

Repeat

Note=4

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Fusion Gene Sequence for BDP1-KDM5A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>9568_9568_1_BDP1-KDM5A_BDP1_chr5_70811993_ENST00000358731_KDM5A_chr12_402303_ENST00000399788_length(transcript)=10930nt_BP=5017nt
AGTTGCGGCGTCCTGTGAGCGCGGGGATGCTGGGAGGAGGGTGAAATTTAGCCATCGGTGTGTGGCAGGGTCATGAAAAAGCGGCGGCGG
CGGGAGAGAGGAGGAGGCGGCGGCGGGGCAGTGAAACTACGGTAGCTGCCCCCTGAGCTGGTGGTGTGGCTTTGTGGGGAGGGCGTAGTT
CCTAATCCCCTTTCCGGGCAGCCGCCGGGGCTCGGGGCTGTGAGCGGCCGTGAGGCTGCCTCCCCGGGCCCCCTGCCTCCGCCATGTTCC
GCAGGGCACGCCTTAGCGTGAAGCCGAATGTCAGGCCTGGTGTAGGCGCCAGGGGCTCCACAGCTTCCAATCCCCAGCGTGGACGGGAGT
CTCCCAGGCCGCCGGATCCTGCCACGGACTCTGCTTCCAAGCCCGCGGAGCCCACAGATGTGCCCACAGTCGATTTCGGTGGAGCGGAGC
CCCAAGAAAAGGCTCCTAGGAGCAGTACTGAAAAGACTGGTGGTGACAATGATGTTGAAGAATCCAGTAGATCTTCCTCTACTGTTTCAC
AGAGAAGAAAGCGAATATCAAGTACTTCTAGCCTGGTTAAGTCTAGTGTCAGTGTTCCTTCAGAATCTCATCCCTTATCTACAATTAATC
AAGAGGCTCCACAGCCAACTGCCACTTCAACAAAAGAGAAACAGCCATGCTCAGACAGATACCGAATATACAAAGCCCAGAAACTGAGGG
AAATGTTAAAAGAAGAATTGAGAAAAGAGAAGAAACAATGGAAAAACAAATATGCTATAAATGAAAGTCAGAGGCCACCAGATCGTTCAA
AAATGACTATGAGAGACTTCATATATTATCTACCAGATAATAATCCAATGACTTCTTCACTGGAACAAGAAAAGAAAACTGAAAAGCCAT
CGACTCCAGTCCAGACAAGAGAGCAAGAAGGTAAGAGTACTCCTAATGCTGAAGATAATGAAATGGAAGAAGAGACAGATGATGGGCCAT
TACTGGTTCCTCGAGTAAAAGTGGCAGAAGATGGTTCCATTATTTTGGATGAAGAAAGTTTAACTGTAGAAGTTTTAAGAACAAAAGGCC
CTTGTGTTGTTGAAGAAAATGACCCCATATTTGAGCGCGGTTCTACAACTACATACTCCAGCTTTAGGAAAAACTATTACTCTAAACCAT
GGTCAAATAAAGAAACAGATATGTTTTTTTTAGCCATCAGCATGGTAGGAACTGACTTTTCTATGATCGGACAACTTTTTCCTCACAGAG
CAAGGATAGAAATTAAGAATAAATTTAAACGGGAAGAGAAAACAAATGGATGGAGAATAGACAAAGCATTCCAGGAAAAGCGCCCTTTTG
ACTTCGATTTTTTTGCTCATTTGCTTCAGAAAGTTCTTGCTGAAGAAGAGAAAAGAAAACAAAAATCTGTTAAAAATCACAGTTTAAAGG
AGAAGAAATCCACCAAACCACGGAAAAATGTAAAAGTGAAAAAAGTTGCCTGTGAAGGAGTGAATAATGATCCAGATGAGTCTATGAGTT
CTAGAATTTCAGACACGGAAAGATCTCAGAAGGATGCTCAGACAGTTGAAGAAGAGTCTCTGACCTTATCAAGGGAGGATGCAGAGCAGG
TTGCATTAGAAGTAGACCTAAATCAAAAGAAAAGAAGGAGGAAGAAGCAAGATGGAGCTAATGAACTGGGAGTAAACAATCTTTTAGAAA
ATGCCACTGTTCAGGCGGGTCCTTCTAAAGGAGAAAAACACAAGAATAAATGTCAGGCTATAAGGCCTGAGCTAAAGGAAGGTGAATGCA
GTAAGGAGCAGATGCTTTCCTGCACACAAAACATAGATGGCATTGTGGGTTTTGCCTCCACTGAAAAAGTTGAGAAAAGAACTGACCCCA
TCCTTTCATTAAGTAATCAACAAGATGCCACATCAGTAGCAACTGAGTCTTCAGAATCAAGCACTTCAGATTTGCCTTCATTCGAAGTTG
GAATTAGAGCATTGTGTGAGGTGAATAATGCTGAGGGTAGTTGTATAGAAGAAAGAAATGTTGACCTAAAAAATAATTCACTGGAAATTG
ATCAAACAGAAAATGTTAAACCAATGTTGAGAGGTCGCTTCCAAAGACCTAAACCCAATTTGTCAAGGGCTGGGAAGAAATCAGTTCTTT
CACAAGGCAAAACAGAGTCAGAGAGCAAGAATTCACATTCAAAAACTTCAGTTGAAAAGAACCACGTGGAAAAAGATAAAATGAATACAT
TGGACATTTTGAGAATGGAGACTACAGAGAGAGAGAATCCAGAAGCTGAAACTGTATCTGTTTTGGGTGAAAAAAATTGTCTGCAGGAAG
GGAGTCAACTAAAGGCTTTAAGACCTGTACAAGTGAGGGGCCGATTGCAAAAGCCAAAGCCAAATGCAGGTAAAGCTGCTGAAAGAAAAG
AAATTCTCATATCACAGGAAGAAATTGGGGCCAATGTAGAGAAGAATGAAAATGAATCCTGTGCTGATAGAGATACTCCTCAACACATGG
AAGATCAATCGCGTAAAGATTTTGAAGAGGAAGATGTCATATTACAGCCTGAGAAAAATGATTCTTTTCAAAATGTGCAGCCAGATGAGC
CCAAGGTTCTTAATGAATGTCTAAGCGTTCAAGAGAATAATAAGGCAAATAAACTTAACCAAGTCCCAATTCTAAGGACTCGATTTCAGA
AACCAAAGCCAAATATAGGAAGAGGAACTGGAAGGAGAGAAATTTCCTCAAAGGAAGAGGTACTAGAGAAGATTCTTGTCTCTGGGGAAA
TGGCGGCAGCATTGAGAGAAACTGTAAGACTAGACACCTCACCAAAGGAGATGGTACCAGCAGAGATTAATACTAAAGAAATGCAGTCAG
ATTTAAAAGAAACTGGAAGAAGAGCCATTTCTCCCAGGGAGAAGATTCTAGATGTGATTGATGACACCATAGAAATGGAGACAGGTCTGA
AAGCAATGGGAAGAGAGATTTGTCTAAGGGAGAAGACGCCAGAGGTGATTGATGCCACTGAGGAAATAGACAAAGATTTGGAAGAAGCTG
GAAGAAGAGAAATATCCCCACAGAAAAATGGCCCAGAGGAGGTTAAGCCTCTAGGTGAAGTGGAGACAGATTTGAAAGCAACTGGAAATG
AGAGTTCCCCAAGGGAGAAGACACCAGAGGTGACTGATGCCACTGAGGAAATAGACAAAAATTTGGAAGAAACTGGAAGAAGAAAAATAT
CCCCAAGGGAAAATGGCCCAGAGGAGGTCAAGCCTGTAGATGAAATGGAGACAGATTTGAACGCAACTGGAAGAGAGAGTTCTCCAAGGG
AGAAGACACCAGAGGTGATTGATGCTACTGAGGAAATAGATTTGGAAGAAACTGAAAGAGAAGTATCCCCACAGGAAAATGGACTAGAGG
AGGTCAAGCCTCTAGGTGAAATGGAGACGGATTTGAAAGCAACTGGAAGAGACAGTTTCCCAAGGGGGAAGACACCAGAGGTGATTGATG
CCATTGAGGAAATAGAGATAGATTTGGAAGAAACTGAAAGAGAAATATCCCCACAGGAAAATGGCCTAGAGGAGGTTAAGCCTCTAGGTG
AAATGCAAACAGATTTGAAAGCAACCGGAAGGGAGATTTCCCCAAGGGAGAAGACACCAGAGGTGATTGATGCCACTGAGGAAATAGACA
AAGATCTGGAAGAAACTGGAAGAAGAGAAATATCCCCAGAGGAAAATGGCCCAGAGGAGGTCAAGCCTGTAGATGAAATGGAGACAGACT
TGAAAACAACTGGAAGAGAGGGTTCCTCAAGGGAGAAGACACGAGAGGTGATTGATGCTGCTGAGGTAATAGAGACAGATTTGGAAGAAA
CTGAAAGAGAAATATCGCCACAGGAAAATGGCCCAGAGGAGGTCAAGCCTGTAGGTAAAATGGAGACAGATTTGAAAGAAATTAGAGAAG
AAATTTCCCAAAGGGAAAAGGTGCTAGCAGAGTTCAGTGCTATAAGGGAAAAGGAGATTGATTTGAAAGAAACTGGAAAAAGAGACATTC
CCATCATGGAGAAAGTATCAGGAAAGATGGCTGTTGTTGAAGAAATGGAGGCAGATTTGAAAGAAACTGGAAAAGAAAATTTTAGAGAGA
GAGGATCTGAAGAGATCTGTGTTACTGAGGAAAAGGTGGCAGAATTGAAACAAACTGGAAAAACAGACATTTCTCCAAGGGAAAACGAGC
TAGAGGAGACCAGTACCTCAAGACAAACTGACACACATTTAATGCAGAGCGGTAGCAATGACTTCAGTGCTGTGCCTTCACTAGATATTC
AGAACATTAGCAGTGAAGTACTGTCGATGATGCATACACCTGTAGAAGAAAAAAGAAATTCTGAAAAAGAAGTATCAAGTCACTTCAGTC
ATTTCAAGATTTCTTCACAGACTCATGAATCTGATAAAACAGAAGTCCAGGGGATTCAATCTCCAGATGTTCCAGAGCAGTTTTCAGATA
TTAATTTAAGCAAATCTCTTCCTCAAGAACAGAAGCCACTTGAAATTAAACCAGCACCTTTTGTGAGGAGCCGATTCAAAAGACCAAAAC
CAAACTTAGCAAGAGCAGCTTTGAAGAGAGAGACTACAGAATCAGAAAAATATATATATGAGAAGAAATCAGAAACCAAGAAAATGGAGA
CTATTGTGATGCAAGAAAATAATGAACAAACTGATACTCTCCCTTCTCAACATGATGAAGCTTCCCTAATGATATCAAGAGAAAAAGACA
CATTAGGTCACAGGAATGAGGAGGCTGTGATATTGCCATGTACACAGACTGAAAGGAACCTTTCACCTTCAAATTCTTGTGAACCTAAAG
AGGAGTCTCAGTCAGCACCAGTCCAGAAAAATGACTCAGTTGTTTCTGTGGGACAGGACAGAGGCAAATAGTAGACAAAGGTGAAGCCAA
AGGCATAATTAAGGAAGGAAGAACGATATTACCAAAAGATGAAACTGAAAAGAAAGTCTTAACTGTGGTAGACTGGGTACAATGTGATGG
TGGCTGTGATGAGTGGTTTCATCAAGTTTGTGTGGGTGTATCTCCAGAAATGGCTGAAAATGAAGATTACATCTGTATAAACTGTGCAAA
GAAGCAGGGGCCAGTTAGCCCAGGTCCAGCACCACCTCCTTCCTTCATAATGAGCTACAAACTACCAATGGAGGATCTTAAAGAGACCAG
TTAGCAGATGCTTGGTTAGTTTGGGACATGGGGGGACATGGACCACATTGAGACCTTAGTCATCAAGTAGAGTGGTTTATATCCACTTGG
AATGTTGCTTCCAAAGATGAATGGCCTTCAGAGAAAGTCCCCTTAGTGCTGGCTTCCTCTTTGCATGGACTCTGTGGGTTACATTCTCTA
TCAACATATCTATGCAGAGGGTGTCTTCTTTGGTACAACAGCCAATATTTCATGTCTCCTTTGAGTGTGGTTTACTGCATTAAGGCCAGA
TGCTTAATTGAGCTCTAGGGTGGCTGGTTAGTATTAATACATTGGTGTGCTAACAGGGCATATAGGATGTGGCTTTTGTCCAGCTGATAG
TAGTTAGAGGCTTACAACTTAGGAGCAGCACCAACTGAAGGTGCTAATTGCTTGGATCTCCTTCATTGGGATAGTTGGAGAGGGATTGGA
GTACCACTTTCCTTCCACTGTTACCTGGTACTTAATGCCCTAAAGATACAACTAGGAGTAACAGGGCCAAAGTTATTTCTGTTAGACGTC
AAGGAATGGTATCACAGTCTATTGACCTCAGCGATTTGTGCTTGTTTGTGCTAGAAGAACATCCCAAATAGGAGAACCTCTCACAAGCTG
GGGCAGGTCACCTTATCTTTGTAAGATGAGGATATCATCTAGATCAGAAATCTGACTAGATTGGATTCTGAGGAGAAGAACCTACTACAA
GGCAAGGAGCCGTTTTTTGGCTTTGAAAAGTCTTGCTGTCTTGGGTCTACATTTTAGGGAAGAGCAGGTACATGGATCCAGGCTTCTGCC
AAAAAAAAAAAGAGAAGAAGATGACGATGATGACCAGTCGTACTATCTTACTGAGCCACAGTGATGCATGCTTTTCGGGGAAAACTTCAT
TCACAAGTATTCCAGACACCAGGCTTCAGGCATGGCCATGAGCAAGACCAGCAAATAACAGCTTTTTGCCTTGCAGCCCTGACCCCAATG
TCTGCTGTTTCCAACACTGGTGATTTCTAACTACGGCCCACAGCAGATGCTGTTGAATAACACCATGGCTTCATCAGAGGATGTGGGGTT
GTAGTACCTCTGGGTGATGAAGTTGTTTTAGTAAATCCATTTTTAAAAAAAAAAAAGGACTTGTTTTTACTTTTTTCTAAATGTCTCTGA
CTACTGACTGTTCTATACATAGATTATTTTTCCTTTTTTAATATACATATATGAATATATAAATATATATATTTACTGTTACCAGCAGCA
TATGACAGAGTTTCAACATCAAAAATCCATTTGGGGGCTTGCTTTTTCTTTTTTGCTTTAAAAAAAAAAATCCCATTCCTTCTTTGTAGT
ACAAGGAGTTAGCACTCCCTCCTCCATCCCAGCCTGACCAGATCTTCCATTTTGCTTTTGTTCATATAGATAATTATATGTCCTTTGTGT
GTTGGGACTTGTCCCTGTCTGTTGGGAAACTTGGTCTCACTCTAGTCTGTGCTGGCTCTTTTTTCTTTTGTGTGTGAATGTTTGAAACTA
TGGTGCTGTGTCCTCTTCCCTCCTGTTGTGTTCTCTGTTCTTCTTAAGGTATTAGGTAAGCTGTATGTAAACTCTTATTAGAAGGGGACT
AATTTTTTTTTAAAGGACAAAAAAAAAAATGACTAAAAATAGTGTTTTGTCATCACTGTCTGGTGTCTTTATTTTGGTTTAAAAAAATCT
GTGGTTTGACTTAAATTCATCAGTTTTCCTTTTAAAGGGGGGATTGGGGTGGACCTAGCAACAGCTTATAGTTTCCTCTTCCCTTTTTGC
CCCAGTCTCTTTTAAAGAACTGTCTTCTAGTAACTAGAAGTGAAATGTACTGTCCAGTTACAGTTTGAGTGGGTATGAGATTTAACTCAA
AAGGAATCTTACAAAAAAAAAGATGTTTTCTTATAAAATCCAATTTCTGTAAATGTTTTCTCTGAAGTTCATACTACCTACTTTTTATTC
ATTCTTAATACTGTATAACATTTTGAGTGTTTTGACTTGTTCAGAGGTTTGTTAGTGTTGCTGTGCATATGTCTTGAGGTCTCATCTGAA
GTAAGTTTGTGTATGATCGAAGATTTCAATGGATATTGCAAGGTAACTAATTAACTGATTTCATAAGTTTTCGTTTTGCCAAGCTAACGA
TTATCAATTAAGAATTTCCTCTGGTTGATGTTATACAAGAAAGCACAATATTTTTTGCCTGTTGATCTTCTTTGTAACAGTCTTCAGATA
TTTGTGGGTTAAAAATTGAATGTAATTTTAAGTGACAGATGCCTGGAATACATTTAAAATTTTTATTTTTCCTTCCTAATCATCCATTAA
CTATTCCACTATCAGTGGAGAGTCATGAGGATGCTGAGAAAGTATGAATAGCTTCCTGTCACCTTCTGACGTTTTGAAACTTAAATATGT
CTTTTCGTTGATACTGTGGGATTTTCTGTATTTACTTGACAGTCATGGAGGATTTGGTATGACTTGACCACAGGTTTAGACCAAGGCTGA
GAAGAACAGAAGGGAGAAATTAATGGCAAAACAAAAAATACACAAATCTGCGGTTTTGGAATTAATGAAACAAGATTCATCTATTTAAAG
AAATGTTGGTGTTCTAATACAAAGCATTATTTTCACTTAGAGAAAATTACTTACTTGCTCCCTTCTGTATTGTAATATTTTGTATTAAGA
CATGATTTAAAATGTCTTTCTACCCTTATCTCCTCTAAACTGCAACTGAAGTTGCAATTCTTCATCATTAGTATTTTAACTCTGGCAAAG
GTTATAGAAAGAAAAATGGAAATATGGTAGGCCTGTGGTATTCTTAAAAGCTAAGTCATTAGAACTATGCAGATCCCCAAGTTTAAAAGT
ACAAATACAGCACCAGTAGTTAGCTTTCTAGCTGGGGGAGAAGACAGGAGATTTTTCTTCCACAGATGTTTATTTTGCTTCCTGATAGGT
ACTGCAGCAAAGCCATGTTGATGTGTAGATGCATGACTTCCTCACTAAGCTGCTGCACACCAGCTTTGCCTGCATGATTCAAATTTGTGC
CTCAGTAAAATTATAAATTATTGCATGTCATACCTTGAATAATGGAAACGGCAAACATTAAACCTGTGATTACCCATAATGTACTTTAAT
AATAAAAAACATGGCAGCCAGGTGCAGTAGAGTGCACCTGTGGTCAGGAGGCTGAAGTGGGAAGATTGCTTCAACCTGTGAGTTTGAGTC
CCGCCTGGTCAACAGCGAGACCCCATGTGTCTGTCTGTCTCTCTCTTTTTTTAAAGGACAGAGGCTAAGCTGTAAGGTTAGCATGGTTCT
GCCTGGGCTTTGCTTCTGTGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCAGG
CTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGG
GCTTTGCTTCTGCGCTTCTGTGCTAGCAGGTGCCCACAAAATGTCTTTTTGAATTTCTTAATTTTTGGGTTCTGGATGCAATTCGTGCAC
GCCAAGAAACTACTTGCTTGTCAGTATTTTAATTCTGTAGTACATGTGTGTGAATATCAGCCAGTACTTACAGTAGGAGGATGAACAGAA
AAACTGAGAAGACCTGTCTTTCAAAAGATGGGTTTATCCACTTTTTAAGGGAAAAAGTGACAGTTTGGCATGGGATTTGAAAAGTGGAAA
TTGTGGAAAAATTGAGCTGTTGAAGTCCCACATATAACCAGATTTAATAAAGCTTCACATGTGAATTAGCTCCATATGTGTGTAGAAGGT
TGCTTTTATAGCAGGTCCTTAAGTACTCCTTTTGAAATTCCTCCTTTTTTTTTAAGTCATACCATTACTTCTTTGGATATGAATGTCCCA
AGTGGTATCTCCTACTGTAGTATGAGGAAGAATGGCTGTTAATGTATTTTTTGAATTTTGGTCTTGTCTTGGCCTGGATCATATCCAGTC
ACCACTATGCAACAAATGATGTGCACTGGGCAAGGATATGATGGGTTATGAAAGCTGTATCTTGTTTGTTTTTTCTTTTGCAGTACTCCA
AGTGGTCTAAACAGGAATGTCTTGTAAAACCTCAAGACTCCCTATTGATTATTCCCTTACATATTTATTTACAATTTATCAGGGTAATTG
GTGGTGCCTTATGAAAAGTATAACTCGATTTCTTGATCTTTGAGCATGTTTTGTGTTTCTTGTGTTTTCTAAAAGAATATTAGATATGGT
TAATTGCATTACATCTAAAAGATTTAAAAAATTGTGTGTATGCTCAGGTTCCCCACACCCATACCCACCCTAACCCCTGTCATTTACATT
GGTGGCAACTTTAAATGGTAACCAAGCAAAAGTACATTTTGATAATGAGTATTGATAATCCTGAGGAAAACTAGTGAGTATATGGGAGCC
ACCTTTGACCTGTGCCAAAGCAGTTTCTAATTTCATTTGCTAACTATAAAATAAAGAACTGAGCCAAAATAATTTGATCAGTGGTGTGAT
TAGCCTATTATCATTGCTGAGAATAGTGTTTTTGGAGTGTGAAGTGATTCCTGAAGATTTCACCTGCCTTCTGTTTCCAGCAAGAATCCA
GTGATGACCAACACATTTCCTCACTTTTGGTTCTTGAGAAGTTTATCCCTTTGCAACAAACCATTAATAGGGAAAACAAGGAAATGCTTT
CCCTTTCTCTTTGGCTTCTTAAAGCTCACAACCAATTCAGACCCCAAGTTACTTCAGAGAAGCAAATGGCACCTTTTCCCCATTGCCAAG
GATCCCAGCTTATGCAGATATGAAGGACGGATCATTTCTGAAAATGTTAAGACTCTGCTTGCAGTGGACTTGGCCTCAGTTTCATGAAAT
GTGTAACTCTGTATGTGTATGTTAGGAGGAGGGTTGGTTGAAAGAGCGGGGGCAGGGAGGGGAATCTGATTACCTCTTGGGAAATAATTT
TCTTGCCAACAAAAAGATACACTTGAAGTTTCTTAAGGTGGCAAGTCCATTAAAAAAAAAAATTGTGTTGGACCCTCCCAGTTTAGATCA
AGTATTTCTTGGGGGTCTTGCTATTGTGGTTGATACCAATAAATGGAAGATCCAGAATATTTTCATTTAAAGCTCAACCATTAATTGGAA
CATGGTGAAACATTGTACACATTGTAAAAGTAGGGAACAGTACAAAAGAATGGAATCAAATACTATATTATGTGAATAAACTAGAGTGAT
TTTGGAATTTCACTCTCTTCAGAAAGGAAAGGACTCTTCAGAGAAGAAACGGAAACGGAAGCTAGAAAAGGTAGAGCAACTTTTTGGAGA
AGGAAAACAGAAGTCCAAGGAGTTAAAGAAAATGGACAAACCTAGAAAGAAGAAATTAAAATTAGGTGCAGACAAATCAAAGGAGCTGAA
TAAACTGGCCAAGAAACTAGCAAAAGAAGAAGAGAGAAAGAAAAAGAAGGAGAAGGCTGCTGCAGCCAAAGTTGAACTTGTGAAAGAGAG
CACTGAAAAGAAAAGAGAGAAAAAGGTGCTGGACATCCCCTCAAAGTATGACTGGTCAGGAGCAGAGGAGTCTGATGATGAGAATGCTGT

>9568_9568_1_BDP1-KDM5A_BDP1_chr5_70811993_ENST00000358731_KDM5A_chr12_402303_ENST00000399788_length(amino acids)=1555AA_BP=
MFRRARLSVKPNVRPGVGARGSTASNPQRGRESPRPPDPATDSASKPAEPTDVPTVDFGGAEPQEKAPRSSTEKTGGDNDVEESSRSSST
VSQRRKRISSTSSLVKSSVSVPSESHPLSTINQEAPQPTATSTKEKQPCSDRYRIYKAQKLREMLKEELRKEKKQWKNKYAINESQRPPD
RSKMTMRDFIYYLPDNNPMTSSLEQEKKTEKPSTPVQTREQEGKSTPNAEDNEMEEETDDGPLLVPRVKVAEDGSIILDEESLTVEVLRT
KGPCVVEENDPIFERGSTTTYSSFRKNYYSKPWSNKETDMFFLAISMVGTDFSMIGQLFPHRARIEIKNKFKREEKTNGWRIDKAFQEKR
PFDFDFFAHLLQKVLAEEEKRKQKSVKNHSLKEKKSTKPRKNVKVKKVACEGVNNDPDESMSSRISDTERSQKDAQTVEEESLTLSREDA
EQVALEVDLNQKKRRRKKQDGANELGVNNLLENATVQAGPSKGEKHKNKCQAIRPELKEGECSKEQMLSCTQNIDGIVGFASTEKVEKRT
DPILSLSNQQDATSVATESSESSTSDLPSFEVGIRALCEVNNAEGSCIEERNVDLKNNSLEIDQTENVKPMLRGRFQRPKPNLSRAGKKS
VLSQGKTESESKNSHSKTSVEKNHVEKDKMNTLDILRMETTERENPEAETVSVLGEKNCLQEGSQLKALRPVQVRGRLQKPKPNAGKAAE
RKEILISQEEIGANVEKNENESCADRDTPQHMEDQSRKDFEEEDVILQPEKNDSFQNVQPDEPKVLNECLSVQENNKANKLNQVPILRTR
FQKPKPNIGRGTGRREISSKEEVLEKILVSGEMAAALRETVRLDTSPKEMVPAEINTKEMQSDLKETGRRAISPREKILDVIDDTIEMET
GLKAMGREICLREKTPEVIDATEEIDKDLEEAGRREISPQKNGPEEVKPLGEVETDLKATGNESSPREKTPEVTDATEEIDKNLEETGRR
KISPRENGPEEVKPVDEMETDLNATGRESSPREKTPEVIDATEEIDLEETEREVSPQENGLEEVKPLGEMETDLKATGRDSFPRGKTPEV
IDAIEEIEIDLEETEREISPQENGLEEVKPLGEMQTDLKATGREISPREKTPEVIDATEEIDKDLEETGRREISPEENGPEEVKPVDEME
TDLKTTGREGSSREKTREVIDAAEVIETDLEETEREISPQENGPEEVKPVGKMETDLKEIREEISQREKVLAEFSAIREKEIDLKETGKR
DIPIMEKVSGKMAVVEEMEADLKETGKENFRERGSEEICVTEEKVAELKQTGKTDISPRENELEETSTSRQTDTHLMQSGSNDFSAVPSL
DIQNISSEVLSMMHTPVEEKRNSEKEVSSHFSHFKISSQTHESDKTEVQGIQSPDVPEQFSDINLSKSLPQEQKPLEIKPAPFVRSRFKR
PKPNLARAALKRETTESEKYIYEKKSETKKMETIVMQENNEQTDTLPSQHDEASLMISREKDTLGHRNEEAVILPCTQTERNLSPSNSCE

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Fusion Gene PPI Analysis for BDP1-KDM5A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	BDP1	chr5:70811993	chr12:402303	ENST00000358731	+	1	39	1_299	0	2625.0	ZBTB43
Hgene	BDP1	chr5:70811993	chr12:402303	ENST00000380675	+	1	38	1_299	0	1360.6666666666667	ZBTB43

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BDP1-KDM5A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BDP1-KDM5A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source