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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:U2AF2-KCNK1 (FusionGDB2 ID:95751)

Fusion Gene Summary for U2AF2-KCNK1

check button Fusion gene summary
Fusion gene informationFusion gene name: U2AF2-KCNK1
Fusion gene ID: 95751
HgeneTgene
Gene symbol

U2AF2

KCNK1

Gene ID

11338

3775

Gene nameU2 small nuclear RNA auxiliary factor 2potassium two pore domain channel subfamily K member 1
SynonymsU2AF65DPK|HOHO|K2P1|K2p1.1|KCNO1|TWIK-1|TWIK1
Cytomap

19q13.42

1q42.2

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor U2AF 65 kDa subunitU2 (RNU2) small nuclear RNA auxiliary factor 2U2 auxiliary factor 65 kDa subunitU2 small nuclear ribonucleoprotein auxiliary factor (65kD)U2 snRNP auxiliary factor large subunithU2AF65potassium channel subfamily K member 1inward rectifying potassium channel protein TWIK-1potassium channel K2P1potassium channel KCNO1potassium channel, two pore domain subfamily K, member 1potassium inwardly-rectifying channel, subfamily K, member 1
Modification date2020031320200320
UniProtAcc.

Q96T54

Ensembl transtripts involved in fusion geneENST00000308924, ENST00000450554, 
ENST00000590551, 		ENST00000366620, 
ENST00000472190, ENST00000366621, 
Fusion gene scores* DoF score12 X 12 X 6=8646 X 3 X 5=90
# samples 136
** MAII scorelog2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: U2AF2 [Title/Abstract] AND KCNK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointU2AF2(56171916)-KCNK1(233802441), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneU2AF2

GO:0000398

mRNA splicing, via spliceosome

1824937

HgeneU2AF2

GO:0031397

negative regulation of protein ubiquitination

24389012

HgeneU2AF2

GO:0033120

positive regulation of RNA splicing

21536736

HgeneU2AF2

GO:0048025

negative regulation of mRNA splicing, via spliceosome

15009664

TgeneKCNK1

GO:0035725

sodium ion transmembrane transport

21653227

TgeneKCNK1

GO:0071805

potassium ion transmembrane transport

21653227|22282804


check buttonFusion gene breakpoints across U2AF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADB472673U2AF2chr19

56171916

+KCNK1chr1

233802441

+


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Fusion Gene ORF analysis for U2AF2-KCNK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000308924ENST00000366620U2AF2chr19

56171916

+KCNK1chr1

233802441

+
5CDS-3UTRENST00000308924ENST00000472190U2AF2chr19

56171916

+KCNK1chr1

233802441

+
5CDS-3UTRENST00000450554ENST00000366620U2AF2chr19

56171916

+KCNK1chr1

233802441

+
5CDS-3UTRENST00000450554ENST00000472190U2AF2chr19

56171916

+KCNK1chr1

233802441

+
In-frameENST00000308924ENST00000366621U2AF2chr19

56171916

+KCNK1chr1

233802441

+
In-frameENST00000450554ENST00000366621U2AF2chr19

56171916

+KCNK1chr1

233802441

+
intron-3CDSENST00000590551ENST00000366621U2AF2chr19

56171916

+KCNK1chr1

233802441

+
intron-3UTRENST00000590551ENST00000366620U2AF2chr19

56171916

+KCNK1chr1

233802441

+
intron-3UTRENST00000590551ENST00000472190U2AF2chr19

56171916

+KCNK1chr1

233802441

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000450554U2AF2chr1956171916+ENST00000366621KCNK1chr1233802441+2795125812191812197
ENST00000308924U2AF2chr1956171916+ENST00000366621KCNK1chr1233802441+1876339300893197

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000450554ENST00000366621U2AF2chr1956171916+KCNK1chr1233802441+0.360754550.63924545
ENST00000308924ENST00000366621U2AF2chr1956171916+KCNK1chr1233802441+0.0222947080.9777053

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Fusion Genomic Features for U2AF2-KCNK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for U2AF2-KCNK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:56171916/chr1:233802441)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KCNK1

Q96T54

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103104_1160337.0IntramembraneHelical%3B Name%3DPore helix 1
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103212_2240337.0IntramembraneHelical%3B Name%3DPore helix 2
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103225_2310337.0IntramembraneOntology_term=ECO:0000269
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103117_1220337.0RegionSelectivity filter 1
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103225_2300337.0RegionSelectivity filter 2
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103293_2990337.0RegionImportant for intracellular retention in recycling endosomes
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103123_1320337.0Topological domainExtracellular
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103157_1810337.0Topological domainCytoplasmic
TgeneKCNK1chr19:56171916chr1:233802441ENST00000366621031_200337.0Topological domainCytoplasmic
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103203_2110337.0Topological domainExtracellular
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103232_2430337.0Topological domainExtracellular
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103268_3360337.0Topological domainCytoplasmic
TgeneKCNK1chr19:56171916chr1:233802441ENST000003666210342_1030337.0Topological domainExtracellular
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103133_1560337.0TransmembraneHelical
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103182_2020337.0TransmembraneHelical
TgeneKCNK1chr19:56171916chr1:233802441ENST000003666210321_410337.0TransmembraneHelical
TgeneKCNK1chr19:56171916chr1:233802441ENST0000036662103244_2670337.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneU2AF2chr19:56171916chr1:233802441ENST00000308924+11227_620476.0Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneU2AF2chr19:56171916chr1:233802441ENST00000450554+11227_620472.0Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneU2AF2chr19:56171916chr1:233802441ENST00000308924+112149_2310476.0DomainRRM 1
HgeneU2AF2chr19:56171916chr1:233802441ENST00000308924+112259_3370476.0DomainRRM 2
HgeneU2AF2chr19:56171916chr1:233802441ENST00000308924+112385_4660476.0DomainRRM 3
HgeneU2AF2chr19:56171916chr1:233802441ENST00000450554+112149_2310472.0DomainRRM 1
HgeneU2AF2chr19:56171916chr1:233802441ENST00000450554+112259_3370472.0DomainRRM 2
HgeneU2AF2chr19:56171916chr1:233802441ENST00000450554+112385_4660472.0DomainRRM 3
HgeneU2AF2chr19:56171916chr1:233802441ENST00000308924+11217_470476.0RegionNecessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner
HgeneU2AF2chr19:56171916chr1:233802441ENST00000450554+11217_470472.0RegionNecessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner


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Fusion Gene Sequence for U2AF2-KCNK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95751_95751_1_U2AF2-KCNK1_U2AF2_chr19_56171916_ENST00000308924_KCNK1_chr1_233802441_ENST00000366621_length(transcript)=1876nt_BP=339nt
GAGGCGAAAGCTGCACAGGGCCCTACGCGGCCGCCTCAGCATGTCGGACTTCGACGAGTTCGAGCGGCAGCTCAACGAGAATAAACAAGA
GCGGGACAAGGAGAACCGGCATCGGAAGCGCAGCCACAGCCGCTCTCGGAGCCGGGACCGCAAACGCCGGAGCCGGAGCCGCGACCGGCG
CAACCGGGACCAGCGGAGCGCCTCCCGGGACAGGCGACGACGCAGCAAACCTTTGACCAGAGGCGCTAAAGAGGAGCACGGTGGACTGAT
GTAAATACTGGGACGTGCCACCCCCAGGCTTTGAGCACATCACCCCAATGCAGTACAAGGCCATGCAAGGTCCAGCGCATCACCGTGCAC
GTCACCCGCAGGCCGGTCCTCTACTTCCACATCCGCTGGGGCTTCTCCAAGCAGGTGGTGGCCATCGTCCATGCCGTGCTCCTTGGGTTT
GTCACTGTGTCCTGCTTCTTCTTCATCCCGGCCGCTGTCTTCTCAGTCCTGGAGGATGACTGGAACTTCCTGGAATCCTTTTATTTTTGT
TTTATTTCCCTGAGCACCATTGGCCTGGGGGATTATGTGCCTGGGGAAGGCTACAATCAAAAATTCAGAGAGCTCTATAAGATTGGGATC
ACGTGTTACCTGCTACTTGGCCTTATTGCCATGTTGGTAGTTCTGGAAACCTTCTGTGAACTCCATGAGCTGAAAAAATTCAGAAAAATG
TTCTATGTGAAGAAGGACAAGGACGAGGATCAGGTGCACATCATAGAGCATGACCAACTGTCCTTCTCCTCGATCACAGACCAGGCAGCT
GGCATGAAAGAGGACCAGAAGCAAAATGAGCCTTTTGTGGCCACCCAGTCATCTGCCTGCGTGGATGGCCCTGCAAACCATTGAGCGTAG
GATTTGTTGCATTATGCTAGAGCACCAGGGTCAGGGTGCAAGGAAGAGGCTTAAGTATGTTCATTTTTATCAGAATGCAAAAGCGAAAAT
TATGTCACTTTAAGAAATAGCTACTGTTTGCAATGTCTTATTAAAAAACAACAAAAAAAGACAAATGGAACAAAGAAGCTGTGACCCCAG
CAGGATGTCTAATATGTGAGGAAATGAGATGTCCACCTAAAATTCATATGTGACAAAATTATCTCGACCTTACATAGGAGGAGAATACTT
GAAGCAGTATGCTGCTGTGGTTAGAAGCAGATTTTATACTTTTAACTGGAAACTTTGGGGTTTGCATTTAGATCATTTAGCTGATGGCTA
AATAGCAAAATTTATATTTAGAAGCAAAAAAAAAAAGCATAGAGATGTGTTTTATAAATAGGTTTATGTGTACTGGTTTGCATGTACCCA
CCCAAAATGATTATTTTTGTAGAATCTAAGTTAAACTTACTATTTATAATGCATAGGTAACCATTAACTATGTACATATAAAGTATAAAT
ATGTTTATATTCTGTACATATGGTTTAGGTCACCAGATCCTAGTGTAGTTCTGAAACTAAGACTATAGATATTTTGTTTCTTTTGATTTC
TCTTTATACTAAAGAATCCAGAGTTGCTACAATAAAATAAGGGGAATAATAAACTTGAGAGTGAATAACCATAGTATTCTGCTGCAATAA
ATGTTTCTACCCTCTTGCGATAGAATGGTGTCAGATGTCTAACATGTTTATAAACATTTTTTTGAATTGAACAGGTTATGAAAAGGATTT
ATTAAAAGGTTAAGATACTTTGTTTTGAAAGTACATTGTGATTTGCAGCCACCTAGCACTAAAGCATAGAACTTAAACACGAATCCCTAA

>95751_95751_1_U2AF2-KCNK1_U2AF2_chr19_56171916_ENST00000308924_KCNK1_chr1_233802441_ENST00000366621_length(amino acids)=197AA_BP=13
MSTSPQCSTRPCKVQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLG
DYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNE

--------------------------------------------------------------
>95751_95751_2_U2AF2-KCNK1_U2AF2_chr19_56171916_ENST00000450554_KCNK1_chr1_233802441_ENST00000366621_length(transcript)=2795nt_BP=1258nt
GCAACCTCCGCAGCGGTCGCGCGCACCCTTCATCCCTCTTGCTGCTTTTGTCTGGCACAACCTTCTCAGGCCCTCCGCGAGGCCGGCCCT
TTTTTTCTTTCACTTTCCCCACCCGGAGAGCCAGGTGCCGAGAACTAGGACCTCGTCCCCTTCTCTATCCCTTCCCCTGATCCATCTCGT
CTCTGTTCTCCTTCCCTTTTCCGTTCCCGAAGCCGGAAGGAGCCGAGGTACCCACGGAAAAAGTCGAAGCTGTCCCCGGAGAGTGAGGCC
TTCACGAAGCGGTGGCGGAAGGAGCCGAAGTTCTCTGATCGGAGGCGTGAGCAAGTGGCATCTCCGGAAAGAGCCGAAACACGGACTCGA
GCTTAATCCCAGGAGGGGCCCGAGGGCGAGATCCGGAAATCTCCGGAAAGAGCCGAAGGCCGGGACGGTTAGGATTGTCGGAAGTGGCCG
ATTGCTTGGACAGGGCCGGCGGAGAAGATCGGAGCAAGTCCGTGGAAGAAGCCAAAGACTGGGACGGATTGAATTGTTGGAAGAACCCGA
ACTCGCAGAGGGGACTGGGCGCAGTGGCACACGAGGACACACGGAAACCTCCGAACGTTGAGGAGATAATCTCGGAAAAGTTACGGAAAC
CTGGGAAGTCGGCGAAACCCTACGTTCGGGTGTTTTCGGAAGCAGCCGAAGCGGCCGCCTGCTTCGCCTTCGTCCAGTATCCGGAGATAG
CCGAGGCGCTTCGGAGCCAGGCTCGGGGGGAGGGGCAAGCTCGCGGGCGGGCGGGCGGGTGAGGGGGCGGAGCCCGGGCGGGGCGGGGAG
GGCTGCCGGAGGCTTGATTAGGTAGGAGGTGGCGAAGCGCCGGCGGCGGCCGGAAGTAGCCGAAGCCAGCGGCGGAAGTAGCCGAAGCGG
CTGGAGCGGGCGGCAAGGCGAGGCGAAAGCTGCACAGGGCCCTACGCGGCCGCCTCAGCATGTCGGACTTCGACGAGTTCGAGCGGCAGC
TCAACGAGAATAAACAAGAGCGGGACAAGGAGAACCGGCATCGGAAGCGCAGCCACAGCCGCTCTCGGAGCCGGGACCGCAAACGCCGGA
GCCGGAGCCGCGACCGGCGCAACCGGGACCAGCGGAGCGCCTCCCGGGACAGGCGACGACGCAGCAAACCTTTGACCAGAGGCGCTAAAG
AGGAGCACGGTGGACTGATGTAAATACTGGGACGTGCCACCCCCAGGCTTTGAGCACATCACCCCAATGCAGTACAAGGCCATGCAAGGT
CCAGCGCATCACCGTGCACGTCACCCGCAGGCCGGTCCTCTACTTCCACATCCGCTGGGGCTTCTCCAAGCAGGTGGTGGCCATCGTCCA
TGCCGTGCTCCTTGGGTTTGTCACTGTGTCCTGCTTCTTCTTCATCCCGGCCGCTGTCTTCTCAGTCCTGGAGGATGACTGGAACTTCCT
GGAATCCTTTTATTTTTGTTTTATTTCCCTGAGCACCATTGGCCTGGGGGATTATGTGCCTGGGGAAGGCTACAATCAAAAATTCAGAGA
GCTCTATAAGATTGGGATCACGTGTTACCTGCTACTTGGCCTTATTGCCATGTTGGTAGTTCTGGAAACCTTCTGTGAACTCCATGAGCT
GAAAAAATTCAGAAAAATGTTCTATGTGAAGAAGGACAAGGACGAGGATCAGGTGCACATCATAGAGCATGACCAACTGTCCTTCTCCTC
GATCACAGACCAGGCAGCTGGCATGAAAGAGGACCAGAAGCAAAATGAGCCTTTTGTGGCCACCCAGTCATCTGCCTGCGTGGATGGCCC
TGCAAACCATTGAGCGTAGGATTTGTTGCATTATGCTAGAGCACCAGGGTCAGGGTGCAAGGAAGAGGCTTAAGTATGTTCATTTTTATC
AGAATGCAAAAGCGAAAATTATGTCACTTTAAGAAATAGCTACTGTTTGCAATGTCTTATTAAAAAACAACAAAAAAAGACAAATGGAAC
AAAGAAGCTGTGACCCCAGCAGGATGTCTAATATGTGAGGAAATGAGATGTCCACCTAAAATTCATATGTGACAAAATTATCTCGACCTT
ACATAGGAGGAGAATACTTGAAGCAGTATGCTGCTGTGGTTAGAAGCAGATTTTATACTTTTAACTGGAAACTTTGGGGTTTGCATTTAG
ATCATTTAGCTGATGGCTAAATAGCAAAATTTATATTTAGAAGCAAAAAAAAAAAGCATAGAGATGTGTTTTATAAATAGGTTTATGTGT
ACTGGTTTGCATGTACCCACCCAAAATGATTATTTTTGTAGAATCTAAGTTAAACTTACTATTTATAATGCATAGGTAACCATTAACTAT
GTACATATAAAGTATAAATATGTTTATATTCTGTACATATGGTTTAGGTCACCAGATCCTAGTGTAGTTCTGAAACTAAGACTATAGATA
TTTTGTTTCTTTTGATTTCTCTTTATACTAAAGAATCCAGAGTTGCTACAATAAAATAAGGGGAATAATAAACTTGAGAGTGAATAACCA
TAGTATTCTGCTGCAATAAATGTTTCTACCCTCTTGCGATAGAATGGTGTCAGATGTCTAACATGTTTATAAACATTTTTTTGAATTGAA
CAGGTTATGAAAAGGATTTATTAAAAGGTTAAGATACTTTGTTTTGAAAGTACATTGTGATTTGCAGCCACCTAGCACTAAAGCATAGAA
CTTAAACACGAATCCCTAAATGAACAGATTATGTTACATTAATCTGAGAATTTTAAATTTAGAAGCTAAAATAAATAAAAATCACAGCTG

>95751_95751_2_U2AF2-KCNK1_U2AF2_chr19_56171916_ENST00000450554_KCNK1_chr1_233802441_ENST00000366621_length(amino acids)=197AA_BP=13
MSTSPQCSTRPCKVQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLG
DYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for U2AF2-KCNK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for U2AF2-KCNK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for U2AF2-KCNK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource