FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:U3-SNORD3C (FusionGDB2 ID:95771)

Fusion Gene Summary for U3-SNORD3C

check button Fusion gene summary
Fusion gene informationFusion gene name: U3-SNORD3C
Fusion gene ID: 95771
HgeneTgene
Gene symbol

U3

SNORD3C

Gene ID

780851

780853

Gene namesmall nucleolar RNA, C/D box 3Asmall nucleolar RNA, C/D box 3C
SynonymsRNU3|U3RNU3-3|U3-3
Cytomap

17p11.2

17p11.2

Type of genesnoRNAsnoRNA
DescriptionRNA, U3 small nucleolarU3 small nucleolar RNA AU3 snoRNA AU3 small nucleolar RNA CU3 snoRNA C
Modification date2020031320200313
UniProtAcc

RRP9

.
Ensembl transtripts involved in fusion geneENST00000364459, ENST00000516490, 
ENST00000362500, ENST00000362796, 
ENST00000362857, ENST00000362899, 
ENST00000362981, ENST00000362986, 
ENST00000363057, ENST00000363172, 
ENST00000363352, ENST00000363448, 
ENST00000363622, ENST00000363668, 
ENST00000363675, ENST00000363823, 
ENST00000364476, ENST00000364498, 
ENST00000364804, ENST00000365363, 
ENST00000365398, ENST00000365612, 
ENST00000384034, ENST00000384391, 
ENST00000384486, ENST00000390863, 
ENST00000390880, ENST00000390893, 
ENST00000390909, ENST00000391019, 
ENST00000391065, ENST00000391120, 
ENST00000391132, ENST00000391177, 
ENST00000391209, ENST00000391236, 
ENST00000391237, ENST00000391249, 
ENST00000391296, ENST00000391308, 
ENST00000408113, ENST00000408116, 
ENST00000408117, ENST00000408198, 
ENST00000408325, ENST00000408405, 
ENST00000408418, ENST00000408473, 
ENST00000408528, ENST00000408534, 
ENST00000408569, ENST00000408706, 
ENST00000408711, ENST00000408746, 
ENST00000410734, ENST00000458938, 
ENST00000515940, ENST00000515984, 
ENST00000515991, ENST00000516027, 
ENST00000516121, ENST00000516135, 
ENST00000516170, ENST00000516239, 
ENST00000516366, ENST00000516380, 
ENST00000516432, ENST00000516631, 
ENST00000516727, ENST00000516734, 
ENST00000516860, ENST00000516874, 
ENST00000516900, ENST00000516983, 
ENST00000516996, ENST00000517112, 
ENST00000517172, ENST00000517200, 
ENST00000517205, ENST00000517243, 
ENST00000517282, ENST00000607547, 
ENST00000362428, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 3 X 2=12
# samples 43
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: U3 [Title/Abstract] AND SNORD3C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointU3(43233501)-SNORD3C(19093498), # samples:1
U3(90989256)-SNORD3C(19093486), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across U3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SNORD3C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3EL-01AU3chr9

90989256

+SNORD3Cchr17

19093486

-
ChimerDB4UCECTCGA-BK-A0CA-01BU3chr8

43233501

+SNORD3Cchr17

19093498

-


Top

Fusion Gene ORF analysis for U3-SNORD3C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000364459ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
3UTR-5UTRENST00000516490ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000362500ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000362500ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000362796ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000362796ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000362857ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000362857ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000362899ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000362899ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000362981ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000362981ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000362986ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000362986ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000363057ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000363057ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000363172ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000363172ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000363352ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000363352ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000363448ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000363448ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000363622ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000363622ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000363668ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000363668ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000363675ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000363675ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000363823ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000363823ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000364459ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000364476ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000364476ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000364498ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000364498ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000364804ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000364804ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000365363ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000365363ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000365398ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000365398ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000365612ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000365612ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000384034ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000384034ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000384391ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000384391ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000384486ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000384486ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000390863ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000390863ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000390880ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000390880ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000390893ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000390893ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000390909ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000390909ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391019ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391019ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391065ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391065ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391120ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391120ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391132ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391132ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391177ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391177ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391209ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391209ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391236ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391236ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391237ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391237ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391249ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391249ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391296ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391296ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000391308ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000391308ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408113ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408113ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408116ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408116ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408117ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408117ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408198ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408198ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408325ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408325ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408405ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408405ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408418ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408418ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408473ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408473ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408528ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408528ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408534ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408534ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408569ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408569ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408706ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408706ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408711ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408711ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000408746ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000408746ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000410734ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000410734ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000458938ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000458938ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000515940ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000515940ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000515984ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000515984ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000515991ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000515991ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516027ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516027ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516121ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516121ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516135ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516135ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516170ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516170ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516239ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516239ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516366ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516366ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516380ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516380ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516432ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516432ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516490ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516631ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516631ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516727ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516727ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516734ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516734ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516860ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516860ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516874ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516874ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516900ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516900ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516983ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516983ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000516996ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000516996ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000517112ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000517112ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000517172ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000517172ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000517200ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000517200ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000517205ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000517205ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000517243ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000517243ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000517282ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000517282ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-
intron-5UTRENST00000607547ENST00000362428U3chr9

90989256

+SNORD3Cchr17

19093486

-
intron-5UTRENST00000607547ENST00000362428U3chr8

43233501

+SNORD3Cchr17

19093498

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for U3-SNORD3C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for U3-SNORD3C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:43233501/:19093498)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
U3

RRP9

.
475FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for U3-SNORD3C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for U3-SNORD3C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for U3-SNORD3C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for U3-SNORD3C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource