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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UBA5-RSU1 (FusionGDB2 ID:95863)

Fusion Gene Summary for UBA5-RSU1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBA5-RSU1
Fusion gene ID: 95863
HgeneTgene
Gene symbol

UBA5

RSU1

Gene ID

79876

6251

Gene nameubiquitin like modifier activating enzyme 5Ras suppressor protein 1
SynonymsEIEE44|SCAR24|THIFP1|UBE1DC1RSP-1
Cytomap

3q22.1

10p13

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-like modifier-activating enzyme 5UBA5, ubiquitin-activating enzyme E1 homologUFM1-activating enzymeubiquitin-activating enzyme 5ubiquitin-activating enzyme E1 domain-containing protein 1ubiquitin-activating enzyme E1-domain containing 1ras suppressor protein 1ras suppressor protein 1 variant 1ras suppressor protein 1 variant 2ras suppressor protein 1 variant 3ras suppressor protein 1 variant 5rsu-1
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000480955, ENST00000356232, 
ENST00000473651, ENST00000493720, 
ENST00000494238, ENST00000264991, 
ENST00000345264, ENST00000377921, 
ENST00000602389, ENST00000464074, 
Fusion gene scores* DoF score2 X 2 X 2=812 X 9 X 4=432
# samples 212
** MAII scorelog2(2/8*10)=1.32192809488736log2(12/432*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBA5 [Title/Abstract] AND RSU1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBA5(132379542)-RSU1(16635495), # samples:1
Anticipated loss of major functional domain due to fusion event.UBA5-RSU1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBA5

GO:0034976

response to endoplasmic reticulum stress

23152784

HgeneUBA5

GO:0071569

protein ufmylation

15071506

HgeneUBA5

GO:1990592

protein K69-linked ufmylation

25219498


check buttonFusion gene breakpoints across UBA5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RSU1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-8574-01AUBA5chr3

132379542

+RSU1chr10

16635495

-


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Fusion Gene ORF analysis for UBA5-RSU1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000480955ENST00000345264UBA5chr3

132379542

+RSU1chr10

16635495

-
3UTR-3CDSENST00000480955ENST00000377921UBA5chr3

132379542

+RSU1chr10

16635495

-
3UTR-3CDSENST00000480955ENST00000602389UBA5chr3

132379542

+RSU1chr10

16635495

-
3UTR-5UTRENST00000480955ENST00000464074UBA5chr3

132379542

+RSU1chr10

16635495

-
5CDS-5UTRENST00000356232ENST00000464074UBA5chr3

132379542

+RSU1chr10

16635495

-
5CDS-5UTRENST00000473651ENST00000464074UBA5chr3

132379542

+RSU1chr10

16635495

-
5CDS-5UTRENST00000493720ENST00000464074UBA5chr3

132379542

+RSU1chr10

16635495

-
5UTR-3CDSENST00000494238ENST00000345264UBA5chr3

132379542

+RSU1chr10

16635495

-
5UTR-3CDSENST00000494238ENST00000377921UBA5chr3

132379542

+RSU1chr10

16635495

-
5UTR-3CDSENST00000494238ENST00000602389UBA5chr3

132379542

+RSU1chr10

16635495

-
5UTR-5UTRENST00000494238ENST00000464074UBA5chr3

132379542

+RSU1chr10

16635495

-
Frame-shiftENST00000356232ENST00000345264UBA5chr3

132379542

+RSU1chr10

16635495

-
Frame-shiftENST00000356232ENST00000602389UBA5chr3

132379542

+RSU1chr10

16635495

-
Frame-shiftENST00000473651ENST00000345264UBA5chr3

132379542

+RSU1chr10

16635495

-
Frame-shiftENST00000473651ENST00000602389UBA5chr3

132379542

+RSU1chr10

16635495

-
Frame-shiftENST00000493720ENST00000345264UBA5chr3

132379542

+RSU1chr10

16635495

-
Frame-shiftENST00000493720ENST00000602389UBA5chr3

132379542

+RSU1chr10

16635495

-
In-frameENST00000356232ENST00000377921UBA5chr3

132379542

+RSU1chr10

16635495

-
In-frameENST00000473651ENST00000377921UBA5chr3

132379542

+RSU1chr10

16635495

-
In-frameENST00000493720ENST00000377921UBA5chr3

132379542

+RSU1chr10

16635495

-
intron-3CDSENST00000264991ENST00000345264UBA5chr3

132379542

+RSU1chr10

16635495

-
intron-3CDSENST00000264991ENST00000377921UBA5chr3

132379542

+RSU1chr10

16635495

-
intron-3CDSENST00000264991ENST00000602389UBA5chr3

132379542

+RSU1chr10

16635495

-
intron-5UTRENST00000264991ENST00000464074UBA5chr3

132379542

+RSU1chr10

16635495

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356232UBA5chr3132379542+ENST00000377921RSU1chr1016635495-411912337521201149
ENST00000493720UBA5chr3132379542+ENST00000377921RSU1chr1016635495-3639753272721149
ENST00000473651UBA5chr3132379542+ENST00000377921RSU1chr1016635495-322533915511928125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356232ENST00000377921UBA5chr3132379542+RSU1chr1016635495-0.525081460.47491857
ENST00000493720ENST00000377921UBA5chr3132379542+RSU1chr1016635495-0.60850740.39149264
ENST00000473651ENST00000377921UBA5chr3132379542+RSU1chr1016635495-0.604180160.3958198

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Fusion Genomic Features for UBA5-RSU1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBA5-RSU1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:132379542/chr10:16635495)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBA5chr3:132379542chr10:16635495ENST00000264991+112334_3460349.0MotifUFM1-interacting sequence (UIS)
HgeneUBA5chr3:132379542chr10:16635495ENST00000356232+112334_34653405.0MotifUFM1-interacting sequence (UIS)
HgeneUBA5chr3:132379542chr10:16635495ENST00000494238+112334_3460349.0MotifUFM1-interacting sequence (UIS)
TgeneRSU1chr3:132379542chr10:16635495ENST0000034526479110_133243278.0RepeatNote=LRR 4
TgeneRSU1chr3:132379542chr10:16635495ENST0000034526479135_156243278.0RepeatNote=LRR 5
TgeneRSU1chr3:132379542chr10:16635495ENST0000034526479158_179243278.0RepeatNote=LRR 6
TgeneRSU1chr3:132379542chr10:16635495ENST0000034526479181_202243278.0RepeatNote=LRR 7
TgeneRSU1chr3:132379542chr10:16635495ENST000003452647941_63243278.0RepeatNote=LRR 1
TgeneRSU1chr3:132379542chr10:16635495ENST000003452647964_85243278.0RepeatNote=LRR 2
TgeneRSU1chr3:132379542chr10:16635495ENST000003452647987_109243278.0RepeatNote=LRR 3
TgeneRSU1chr3:132379542chr10:16635495ENST0000037792168110_133243278.0RepeatNote=LRR 4
TgeneRSU1chr3:132379542chr10:16635495ENST0000037792168135_156243278.0RepeatNote=LRR 5
TgeneRSU1chr3:132379542chr10:16635495ENST0000037792168158_179243278.0RepeatNote=LRR 6
TgeneRSU1chr3:132379542chr10:16635495ENST0000037792168181_202243278.0RepeatNote=LRR 7
TgeneRSU1chr3:132379542chr10:16635495ENST000003779216841_63243278.0RepeatNote=LRR 1
TgeneRSU1chr3:132379542chr10:16635495ENST000003779216864_85243278.0RepeatNote=LRR 2
TgeneRSU1chr3:132379542chr10:16635495ENST000003779216887_109243278.0RepeatNote=LRR 3
TgeneRSU1chr3:132379542chr10:16635495ENST0000060238968110_133190225.0RepeatNote=LRR 4
TgeneRSU1chr3:132379542chr10:16635495ENST0000060238968135_156190225.0RepeatNote=LRR 5
TgeneRSU1chr3:132379542chr10:16635495ENST0000060238968158_179190225.0RepeatNote=LRR 6
TgeneRSU1chr3:132379542chr10:16635495ENST0000060238968181_202190225.0RepeatNote=LRR 7
TgeneRSU1chr3:132379542chr10:16635495ENST000006023896841_63190225.0RepeatNote=LRR 1
TgeneRSU1chr3:132379542chr10:16635495ENST000006023896864_85190225.0RepeatNote=LRR 2
TgeneRSU1chr3:132379542chr10:16635495ENST000006023896887_109190225.0RepeatNote=LRR 3


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Fusion Gene Sequence for UBA5-RSU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95863_95863_1_UBA5-RSU1_UBA5_chr3_132379542_ENST00000356232_RSU1_chr10_16635495_ENST00000377921_length(transcript)=4119nt_BP=1233nt
ATGCCTGTAGGGTGCGTCCACTGACTGCAGGAAAAGCAATCAGGGTGGGAGAAACTTAGGAAACCACCCAGGGCCAAAGGAAGGAAAACT
CAATGTACAAATTTTTTTCCGCTGGAGGCAAAGGCTGACATCCATACCTGTACTGGGCAATGGTCAGCGTAGCCTCACGTTCGGCCCCAA
AGCCAGACAAGTGCTGGTTTAGGTAGGCCTCCAGGGACTTGCTGTCGAACTTGTGCTGGGGCAGCACTTCGGCCAAATCGGACTCGCCAG
TAGCACCTGGCTTCATGATCACCCCCGCAGGCCACAGCAACGCGGCATCCACAGGTCTCGAGTGCCGAAGTCCTTCAGGATTGGGGCAAC
GTCCCCTCTAGAGCATGGGCCGAGGCCGGGGTGGGGTCTGGCTCCAGCCAACCGCACACAGCCTACGCGCCGTTGCTGAGCAACGCTTGC
CCGCTGAATCCCGAGGTTTTAGCTCTAGTCAAGTGCCAAAAGAGCCCAATGTGTGTTCGGGTTTCAATTCTCCAGTCAGCGTCAGAGTTG
GAGGCCTCAATTTTAAAGAAGGCAAAGCCATGGTCATCGTTGCGGGTAAGGAACAACGCAGAAGCCTCTTCCACCCCCAAATTTAATGCA
ACAGCAGGCGGAAGACCTGCAGGGTCCCGTTCAGAAAAAGGGCCGTCAGACTGTCGAGCCTAAGAATAAAAAGACCCTGTTTCTCTTAGA
TACCCGGTTAGCAAGGCAACATCGCTGGCCTCCTGCCCTGGACACTTATCACCCCGGTGCTGCTGCGGCCGGGTTTAGCCGGCCCAGCGA
GGAAGGAAGCCGAAAGAGCCAGGTTTTTGATGAGGGGGAGCGATGTCTGCGACGCACCGGAAGCGGCTCCGAGGAAGGCCTGTGGGAGTC
TCGGAGACGTGTCTGTCTGTGAGGCGCTGGGTGCACGTCCCCAGGGCTCTGGGCTAGGAAGGCAGCGGCGAGGTGCCTCCCCACGTACCC
CTCGCGGGCCCAGCCGAGCAACGTGGGGCGAAGGCGGCGGCGAAGGCCCGGGCTGGGAGCGTTGGCGGCCGGAGTCCCAGCCATGGCGGA
GTCTGTGGAGCGCCTGCAGCAGCGGGTCCAGGAGCTGGAGCGGGAACTTGCCCAGGAGAGGAGTCTGCAGGTCCCGAGGAGCGGCGACGG
AGGGGGCGGCCGGGTCCGCATCGAGAAGATGAGCTCAGAGGTGGTGGATTCGAATCCCTACAGCCTCTACGGCAGACACATGCAGGCCAA
CCCAGAACCACCGAAGAAGAATAATGACAAATCGAAAAAGATCAGCCGGAAACCCCTGGCAGCCAAGAACAGATAAGGAAGGGATTGGCA
TCGGCTGGCCTTCCAGCACCTTCTCTCTCCAACACTTCATTCTCTCTTGCCCTGTCTCTCAAATAAACCCAATGCTGCGTGTGAGGCCTT
TTTTATTTTTCTTTTCACTCTCTTTCTAATGCTTCCCACCTTACCTTTTAGATTCTTTTGCTAGGTGGGAGATTGTTATAAGGTCTTTAA
ACCATTTCCATTTGTTTCTTTAACATTACCAAAAGCAGGGAACAAAGCTCTTATTCAACTGCGAATTCCATAGTGGGCTCTGGCTTTTCT
TGAATAGATATCACAAGGTTGCTTATTATCAAAAGAATAATTAAAATCATGTAACCATTTAAATGTCACTGTTAACACTTTTCACTCTTT
CTGTTGATTCACCTAACTCATTATTTTGCTTTATTAAAAGTCTTCCTTCACCACCGAGATATGCTAATTTAACTTACAAATGATTTTAAT
AAAATCTTGAGTTTGTATCACATGTTACTTATTGACTCAGAATAAAAGAACAGTCTGATCTTGGGGTATAACACATTTTCATTTACTTTT
CTCCCCCAAAATCATCTTATCCAATTTTATTGGTTATACATGATAAACTTTTCATGAAAGAAATGCAAAATTAAATCACAGTTCGTTTCT
TCTCACATTAATTTGTCAAGTTTTTTTTTTCTTTGAAGACTTTCTAAATTAGGAAGCAGAAAAACAAATCTCTAGGAGATTCTGCCAAAG
GATTTTGGAAAGTAGCATTCCTTCGCCGAAGAAATGGTGATTTCTGCCAGGGGCTGGTAGACAAGAACTGTGAAAGAGAGAGAGAAAAAA
CCTCAACTGTGTATTTTGTCACGGCGGAAAATCTGCTCGCATCGAAGCATTCTTCTAAGCGACTTCGATGCCAAGGAAGTTGTGTAAATG
TGCACGCGCTACACCACACCCAGGGTGGAAACCACAGTTGCAGAGTCATTAAACAATCAATTGTTTGTTTAACATCTGTGATAGGCAGCT
TTCCTTCTTTTCAACAGTGATACCTACGAAAATCAAAATAAATGCAAGCTGAGGTTTTGTGCTCACTGAAAGGGCTGTCAACCCCAGAAG
GCCGACACAAAAAAAATGGTATGTGAAGATGCACCGTCTTTTCAAATGGCCTGGGAGAGTCAAATGGCCTGGGAGAGGGGGCCTGCCCTT
CTCTGCTGTGTCCTTTCGGCTTCCCAGTTGAGCTCCCAAGACCAGGACCCACTGGGGCATATAAAATCTCTGCTGTATCCTTTCGGCTTC
CCAGTTGAGCTCCCAAGACCAGGACCCACTGGGGCATATAAAAAAGTCAAAAATCAAAATCAAACAACAAGTTCTGAGTTACTTAGGAAA
CAGACTTCGCATTTCAATCAGAGAGGCCACAGAGCAAGGTCTAAACTTCTGGCTTCTAGACAAATTCCTGATAGAACATTTAAATGTGGG
AAGTGGCTTCCCCAGGTCCCATCCCCTGTTTAGGGATAGAGTTGATATCATTTTTATAGGTGCCATGTATGCCTCTGCCTGAATTTTTTT
AATTGACTTTTGAGCTTTTGAGATTGCACGAGGGAGAACAAGGCCTTTGCTGTTGTGGATAGGAAAGACTTAACCTAAAATTAAACCAGC
AAGAAAGCATTAGTAAAAATCTAACAATATGAAGGGCTCTTATGAGTCATTTTTTTCAAAAGATGAAAACTCCAGAAACGCACAGGAACG
AAATACCTCCCAGAAACATGAAGCAATCATCGAAGACTCACTGGTAATATTTTTAAAAAGTATACAGATCAAAGCAAAAAGAAGCCATGT
GTAACAAAGAGAAATGTGCAAATATTTTTTAAGGCAGTATTAAGTGCAAGAGGAGTAACATGAAATAAACATTCTTTCACATGGCTACTG
GGAATATAAATTTCGCTCCAGAAAGGCCGTAGCAGTTTGACGATAGGTGGCAAAACCTTAAGATTGTGTACTGGGGCCCAGAATTTTTAT
TTCTAGGAATGTATCCTGAGGAAATTATCCGAGATCCCCACAAACTGCAATGTTTAGGAATTGTCCTTATAGCATTGCATACACAAGAAA
AACAGAGAAAAGCCTGATCCCTGTCAGTGGAAAAGGGGTTCAATGAATTACGGTGTGTCTGCATGAGGCTTTTATGACATTAAAAATTGT
TGAACAACGGCCAGGCACAGTGGCTCATGCCTGTAATCCTAACACTTTGGGAGGCCAAGGTGGGAAGATTGCCTGAGCTCAGGAGTTTGA
GACCAGCCTGGGCAACACGGTGAAACCCCGTCTCTACTAAAATACAAAAAATTAGCCGGGCGTCGCAGCATGCGCCTGTAGTCCCAGCTG
CTCAGGAGGCTGAGGCAGGAGAATTGATTGAACCCGGGAGGCAGAGGTTGCACTGAGCTGAGATTAAGCCACCGCACTCCAGCCTGGGCG
ACAGAGCAAGATTCCGTTCCCAAGAAAAAAAAATTGTTCAACAATAAGGGCAAAGGGAGAGAATCATAACATCTGATTAAACAGAAAAAG
CAAGATTTTTAAAACTAACTATATAAGGATGGTCCCAGCTGTGTCAAAAGGAAGCTTGTTTGTAATACGTGTGCATAAAAATTAAATAGA
GGTGAACACAATTATTTTAAGGCAGTTAAATTATCTCTGTATTGTGAACTAAGACTTTCTAGAATTTTACTTATTCATTCTGTACTTAAA

>95863_95863_1_UBA5-RSU1_UBA5_chr3_132379542_ENST00000356232_RSU1_chr10_16635495_ENST00000377921_length(amino acids)=149AA_BP=
MPWTLITPVLLRPGLAGPARKEAERARFLMRGSDVCDAPEAAPRKACGSLGDVSVCEALGARPQGSGLGRQRRGASPRTPRGPSRATWGE

--------------------------------------------------------------
>95863_95863_2_UBA5-RSU1_UBA5_chr3_132379542_ENST00000473651_RSU1_chr10_16635495_ENST00000377921_length(transcript)=3225nt_BP=339nt
GGAGTCTCGGAGACGTGTCTGTCTGTGAGGCGCTGGGTGCACGTCCCCAGGGCTCTGGGCTAGGAAGGCAGCGGCGAGGTGCCTCCCCAC
GTACCCCTCGCGGGCCCAGCCGAGCAACGTGGGGCGAAGGCGGCGGCGAAGGCCCGGGCTGGGAGCGTTGGCGGCCGGAGTCCCAGCCAT
GGCGGAGTCTGTGGAGCGCCTGCAGCAGCGGGTCCAGGAGCTGGAGCGGGAACTTGCCCAGGAGAGGAGTCTGCAGGTCCCGAGGAGCGG
CGACGGAGGGGGCGGCCGGGTCCGCATCGAGAAGATGAGCTCAGAGGTGGTGGATTCGAATCCCTACAGCCTCTACGGCAGACACATGCA
GGCCAACCCAGAACCACCGAAGAAGAATAATGACAAATCGAAAAAGATCAGCCGGAAACCCCTGGCAGCCAAGAACAGATAAGGAAGGGA
TTGGCATCGGCTGGCCTTCCAGCACCTTCTCTCTCCAACACTTCATTCTCTCTTGCCCTGTCTCTCAAATAAACCCAATGCTGCGTGTGA
GGCCTTTTTTATTTTTCTTTTCACTCTCTTTCTAATGCTTCCCACCTTACCTTTTAGATTCTTTTGCTAGGTGGGAGATTGTTATAAGGT
CTTTAAACCATTTCCATTTGTTTCTTTAACATTACCAAAAGCAGGGAACAAAGCTCTTATTCAACTGCGAATTCCATAGTGGGCTCTGGC
TTTTCTTGAATAGATATCACAAGGTTGCTTATTATCAAAAGAATAATTAAAATCATGTAACCATTTAAATGTCACTGTTAACACTTTTCA
CTCTTTCTGTTGATTCACCTAACTCATTATTTTGCTTTATTAAAAGTCTTCCTTCACCACCGAGATATGCTAATTTAACTTACAAATGAT
TTTAATAAAATCTTGAGTTTGTATCACATGTTACTTATTGACTCAGAATAAAAGAACAGTCTGATCTTGGGGTATAACACATTTTCATTT
ACTTTTCTCCCCCAAAATCATCTTATCCAATTTTATTGGTTATACATGATAAACTTTTCATGAAAGAAATGCAAAATTAAATCACAGTTC
GTTTCTTCTCACATTAATTTGTCAAGTTTTTTTTTTCTTTGAAGACTTTCTAAATTAGGAAGCAGAAAAACAAATCTCTAGGAGATTCTG
CCAAAGGATTTTGGAAAGTAGCATTCCTTCGCCGAAGAAATGGTGATTTCTGCCAGGGGCTGGTAGACAAGAACTGTGAAAGAGAGAGAG
AAAAAACCTCAACTGTGTATTTTGTCACGGCGGAAAATCTGCTCGCATCGAAGCATTCTTCTAAGCGACTTCGATGCCAAGGAAGTTGTG
TAAATGTGCACGCGCTACACCACACCCAGGGTGGAAACCACAGTTGCAGAGTCATTAAACAATCAATTGTTTGTTTAACATCTGTGATAG
GCAGCTTTCCTTCTTTTCAACAGTGATACCTACGAAAATCAAAATAAATGCAAGCTGAGGTTTTGTGCTCACTGAAAGGGCTGTCAACCC
CAGAAGGCCGACACAAAAAAAATGGTATGTGAAGATGCACCGTCTTTTCAAATGGCCTGGGAGAGTCAAATGGCCTGGGAGAGGGGGCCT
GCCCTTCTCTGCTGTGTCCTTTCGGCTTCCCAGTTGAGCTCCCAAGACCAGGACCCACTGGGGCATATAAAATCTCTGCTGTATCCTTTC
GGCTTCCCAGTTGAGCTCCCAAGACCAGGACCCACTGGGGCATATAAAAAAGTCAAAAATCAAAATCAAACAACAAGTTCTGAGTTACTT
AGGAAACAGACTTCGCATTTCAATCAGAGAGGCCACAGAGCAAGGTCTAAACTTCTGGCTTCTAGACAAATTCCTGATAGAACATTTAAA
TGTGGGAAGTGGCTTCCCCAGGTCCCATCCCCTGTTTAGGGATAGAGTTGATATCATTTTTATAGGTGCCATGTATGCCTCTGCCTGAAT
TTTTTTAATTGACTTTTGAGCTTTTGAGATTGCACGAGGGAGAACAAGGCCTTTGCTGTTGTGGATAGGAAAGACTTAACCTAAAATTAA
ACCAGCAAGAAAGCATTAGTAAAAATCTAACAATATGAAGGGCTCTTATGAGTCATTTTTTTCAAAAGATGAAAACTCCAGAAACGCACA
GGAACGAAATACCTCCCAGAAACATGAAGCAATCATCGAAGACTCACTGGTAATATTTTTAAAAAGTATACAGATCAAAGCAAAAAGAAG
CCATGTGTAACAAAGAGAAATGTGCAAATATTTTTTAAGGCAGTATTAAGTGCAAGAGGAGTAACATGAAATAAACATTCTTTCACATGG
CTACTGGGAATATAAATTTCGCTCCAGAAAGGCCGTAGCAGTTTGACGATAGGTGGCAAAACCTTAAGATTGTGTACTGGGGCCCAGAAT
TTTTATTTCTAGGAATGTATCCTGAGGAAATTATCCGAGATCCCCACAAACTGCAATGTTTAGGAATTGTCCTTATAGCATTGCATACAC
AAGAAAAACAGAGAAAAGCCTGATCCCTGTCAGTGGAAAAGGGGTTCAATGAATTACGGTGTGTCTGCATGAGGCTTTTATGACATTAAA
AATTGTTGAACAACGGCCAGGCACAGTGGCTCATGCCTGTAATCCTAACACTTTGGGAGGCCAAGGTGGGAAGATTGCCTGAGCTCAGGA
GTTTGAGACCAGCCTGGGCAACACGGTGAAACCCCGTCTCTACTAAAATACAAAAAATTAGCCGGGCGTCGCAGCATGCGCCTGTAGTCC
CAGCTGCTCAGGAGGCTGAGGCAGGAGAATTGATTGAACCCGGGAGGCAGAGGTTGCACTGAGCTGAGATTAAGCCACCGCACTCCAGCC
TGGGCGACAGAGCAAGATTCCGTTCCCAAGAAAAAAAAATTGTTCAACAATAAGGGCAAAGGGAGAGAATCATAACATCTGATTAAACAG
AAAAAGCAAGATTTTTAAAACTAACTATATAAGGATGGTCCCAGCTGTGTCAAAAGGAAGCTTGTTTGTAATACGTGTGCATAAAAATTA
AATAGAGGTGAACACAATTATTTTAAGGCAGTTAAATTATCTCTGTATTGTGAACTAAGACTTTCTAGAATTTTACTTATTCATTCTGTA

>95863_95863_2_UBA5-RSU1_UBA5_chr3_132379542_ENST00000473651_RSU1_chr10_16635495_ENST00000377921_length(amino acids)=125AA_BP=
MVCEDAPSFQMAWESQMAWERGPALLCCVLSASQLSSQDQDPLGHIKSLLYPFGFPVELPRPGPTGAYKKVKNQNQTTSSELLRKQTSHF

--------------------------------------------------------------
>95863_95863_3_UBA5-RSU1_UBA5_chr3_132379542_ENST00000493720_RSU1_chr10_16635495_ENST00000377921_length(transcript)=3639nt_BP=753nt
AAGTGCCAAAAGAGCCCAATGTGTGTTCGGGTTTCAATTCTCCAGTCAGCGTCAGAGTTGGAGGCCTCAATTTTAAAGAAGGCAAAGCCA
TGGTCATCGTTGCGGGTAAGGAACAACGCAGAAGCCTCTTCCACCCCCAAATTTAATGCAACAGCAGGCGGAAGACCTGCAGGGTCCCGT
TCAGAAAAAGGGCCGTCAGACTGTCGAGCCTAAGAATAAAAAGACCCTGTTTCTCTTAGATACCCGGTTAGCAAGGCAACATCGCTGGCC
TCCTGCCCTGGACACTTATCACCCCGGTGCTGCTGCGGCCGGGTTTAGCCGGCCCAGCGAGGAAGGAAGCCGAAAGAGCCAGGTTTTTGA
TGAGGGGGAGCGATGTCTGCGACGCACCGGAAGCGGCTCCGAGGAAGGCCTGTGGGAGTCTCGGAGACGTGTCTGTCTGTGAGGCGCTGG
GTGCACGTCCCCAGGGCTCTGGGCTAGGAAGGCAGCGGCGAGGTGCCTCCCCACGTACCCCTCGCGGGCCCAGCCGAGCAACGTGGGGCG
AAGGCGGCGGCGAAGGCCCGGGCTGGGAGCGTTGGCGGCCGGAGTCCCAGCCATGGCGGAGTCTGTGGAGCGCCTGCAGCAGCGGGTCCA
GGAGCTGGAGCGGGAACTTGCCCAGGAGAGGAGTCTGCAGGTCCCGAGGAGCGGCGACGGAGGGGGCGGCCGGGTCCGCATCGAGAAGAT
GAGCTCAGAGGTGGTGGATTCGAATCCCTACAGCCTCTACGGCAGACACATGCAGGCCAACCCAGAACCACCGAAGAAGAATAATGACAA
ATCGAAAAAGATCAGCCGGAAACCCCTGGCAGCCAAGAACAGATAAGGAAGGGATTGGCATCGGCTGGCCTTCCAGCACCTTCTCTCTCC
AACACTTCATTCTCTCTTGCCCTGTCTCTCAAATAAACCCAATGCTGCGTGTGAGGCCTTTTTTATTTTTCTTTTCACTCTCTTTCTAAT
GCTTCCCACCTTACCTTTTAGATTCTTTTGCTAGGTGGGAGATTGTTATAAGGTCTTTAAACCATTTCCATTTGTTTCTTTAACATTACC
AAAAGCAGGGAACAAAGCTCTTATTCAACTGCGAATTCCATAGTGGGCTCTGGCTTTTCTTGAATAGATATCACAAGGTTGCTTATTATC
AAAAGAATAATTAAAATCATGTAACCATTTAAATGTCACTGTTAACACTTTTCACTCTTTCTGTTGATTCACCTAACTCATTATTTTGCT
TTATTAAAAGTCTTCCTTCACCACCGAGATATGCTAATTTAACTTACAAATGATTTTAATAAAATCTTGAGTTTGTATCACATGTTACTT
ATTGACTCAGAATAAAAGAACAGTCTGATCTTGGGGTATAACACATTTTCATTTACTTTTCTCCCCCAAAATCATCTTATCCAATTTTAT
TGGTTATACATGATAAACTTTTCATGAAAGAAATGCAAAATTAAATCACAGTTCGTTTCTTCTCACATTAATTTGTCAAGTTTTTTTTTT
CTTTGAAGACTTTCTAAATTAGGAAGCAGAAAAACAAATCTCTAGGAGATTCTGCCAAAGGATTTTGGAAAGTAGCATTCCTTCGCCGAA
GAAATGGTGATTTCTGCCAGGGGCTGGTAGACAAGAACTGTGAAAGAGAGAGAGAAAAAACCTCAACTGTGTATTTTGTCACGGCGGAAA
ATCTGCTCGCATCGAAGCATTCTTCTAAGCGACTTCGATGCCAAGGAAGTTGTGTAAATGTGCACGCGCTACACCACACCCAGGGTGGAA
ACCACAGTTGCAGAGTCATTAAACAATCAATTGTTTGTTTAACATCTGTGATAGGCAGCTTTCCTTCTTTTCAACAGTGATACCTACGAA
AATCAAAATAAATGCAAGCTGAGGTTTTGTGCTCACTGAAAGGGCTGTCAACCCCAGAAGGCCGACACAAAAAAAATGGTATGTGAAGAT
GCACCGTCTTTTCAAATGGCCTGGGAGAGTCAAATGGCCTGGGAGAGGGGGCCTGCCCTTCTCTGCTGTGTCCTTTCGGCTTCCCAGTTG
AGCTCCCAAGACCAGGACCCACTGGGGCATATAAAATCTCTGCTGTATCCTTTCGGCTTCCCAGTTGAGCTCCCAAGACCAGGACCCACT
GGGGCATATAAAAAAGTCAAAAATCAAAATCAAACAACAAGTTCTGAGTTACTTAGGAAACAGACTTCGCATTTCAATCAGAGAGGCCAC
AGAGCAAGGTCTAAACTTCTGGCTTCTAGACAAATTCCTGATAGAACATTTAAATGTGGGAAGTGGCTTCCCCAGGTCCCATCCCCTGTT
TAGGGATAGAGTTGATATCATTTTTATAGGTGCCATGTATGCCTCTGCCTGAATTTTTTTAATTGACTTTTGAGCTTTTGAGATTGCACG
AGGGAGAACAAGGCCTTTGCTGTTGTGGATAGGAAAGACTTAACCTAAAATTAAACCAGCAAGAAAGCATTAGTAAAAATCTAACAATAT
GAAGGGCTCTTATGAGTCATTTTTTTCAAAAGATGAAAACTCCAGAAACGCACAGGAACGAAATACCTCCCAGAAACATGAAGCAATCAT
CGAAGACTCACTGGTAATATTTTTAAAAAGTATACAGATCAAAGCAAAAAGAAGCCATGTGTAACAAAGAGAAATGTGCAAATATTTTTT
AAGGCAGTATTAAGTGCAAGAGGAGTAACATGAAATAAACATTCTTTCACATGGCTACTGGGAATATAAATTTCGCTCCAGAAAGGCCGT
AGCAGTTTGACGATAGGTGGCAAAACCTTAAGATTGTGTACTGGGGCCCAGAATTTTTATTTCTAGGAATGTATCCTGAGGAAATTATCC
GAGATCCCCACAAACTGCAATGTTTAGGAATTGTCCTTATAGCATTGCATACACAAGAAAAACAGAGAAAAGCCTGATCCCTGTCAGTGG
AAAAGGGGTTCAATGAATTACGGTGTGTCTGCATGAGGCTTTTATGACATTAAAAATTGTTGAACAACGGCCAGGCACAGTGGCTCATGC
CTGTAATCCTAACACTTTGGGAGGCCAAGGTGGGAAGATTGCCTGAGCTCAGGAGTTTGAGACCAGCCTGGGCAACACGGTGAAACCCCG
TCTCTACTAAAATACAAAAAATTAGCCGGGCGTCGCAGCATGCGCCTGTAGTCCCAGCTGCTCAGGAGGCTGAGGCAGGAGAATTGATTG
AACCCGGGAGGCAGAGGTTGCACTGAGCTGAGATTAAGCCACCGCACTCCAGCCTGGGCGACAGAGCAAGATTCCGTTCCCAAGAAAAAA
AAATTGTTCAACAATAAGGGCAAAGGGAGAGAATCATAACATCTGATTAAACAGAAAAAGCAAGATTTTTAAAACTAACTATATAAGGAT
GGTCCCAGCTGTGTCAAAAGGAAGCTTGTTTGTAATACGTGTGCATAAAAATTAAATAGAGGTGAACACAATTATTTTAAGGCAGTTAAA
TTATCTCTGTATTGTGAACTAAGACTTTCTAGAATTTTACTTATTCATTCTGTACTTAAATTTTTTCTAATGAACACATATACTTTTGTA

>95863_95863_3_UBA5-RSU1_UBA5_chr3_132379542_ENST00000493720_RSU1_chr10_16635495_ENST00000377921_length(amino acids)=149AA_BP=
MPWTLITPVLLRPGLAGPARKEAERARFLMRGSDVCDAPEAAPRKACGSLGDVSVCEALGARPQGSGLGRQRRGASPRTPRGPSRATWGE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for UBA5-RSU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UBA5-RSU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UBA5-RSU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource