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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UBAP1-UNC13B (FusionGDB2 ID:95915)

Fusion Gene Summary for UBAP1-UNC13B

Fusion gene summary

Fusion gene information	Fusion gene name: UBAP1-UNC13B
	Fusion gene ID: 95915
		Hgene	Tgene
	Gene symbol	UBAP1	UNC13B
	Gene ID	51271	10497
	Gene name	ubiquitin associated protein 1	unc-13 homolog B
	Synonyms	NAG20\|SPG80\|UAP\|UBAP\|UBAP-1	MUNC13\|UNC13\|Unc13h2\|munc13-2
	Cytomap	9p13.3	9p13.3
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin-associated protein 1nasopharyngeal carcinoma-associated gene 20 protein	protein unc-13 homolog Bhomolog of rat Munc13 (diacylglycerol-binding)unc-13-like
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000297661, ENST00000359544, ENST00000379186, ENST00000536252, ENST00000540348, ENST00000543944, ENST00000545103,	ENST00000481299, ENST00000378495, ENST00000378496, ENST00000396787,
Fusion gene scores	* DoF score	16 X 12 X 7=1344	12 X 10 X 7=840
	# samples	18	13
	** MAII score	log2(18/1344*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/840*10)=-2.69187770463767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UBAP1 [Title/Abstract] AND UNC13B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UBAP1(34220946)-UNC13B(35258990), # samples:3
Anticipated loss of major functional domain due to fusion event.	UBAP1-UNC13B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	UNC13B	GO:0043065	positive regulation of apoptotic process	10233166
Tgene	UNC13B	GO:0050714	positive regulation of protein secretion	19641095
Tgene	UNC13B	GO:0060478	acrosomal vesicle exocytosis	22248876
Tgene	UNC13B	GO:0071333	cellular response to glucose stimulus	19641095

Fusion gene breakpoints across UBAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UNC13B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-O2-A5IB-01A	UBAP1	chr9	34220946	-	UNC13B	chr9	35258990	+
ChimerDB4	LUSC	TCGA-O2-A5IB-01A	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
ChimerDB4	LUSC	TCGA-O2-A5IB	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+

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Fusion Gene ORF analysis for UBAP1-UNC13B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000297661	ENST00000481299	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
5CDS-intron	ENST00000359544	ENST00000481299	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
5CDS-intron	ENST00000379186	ENST00000481299	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
5CDS-intron	ENST00000536252	ENST00000481299	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
5CDS-intron	ENST00000540348	ENST00000481299	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
5CDS-intron	ENST00000543944	ENST00000481299	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000297661	ENST00000378495	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000297661	ENST00000378496	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000297661	ENST00000396787	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000359544	ENST00000378495	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000359544	ENST00000378496	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000359544	ENST00000396787	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000379186	ENST00000378495	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000379186	ENST00000378496	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000379186	ENST00000396787	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000536252	ENST00000378495	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000536252	ENST00000378496	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000536252	ENST00000396787	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000540348	ENST00000378495	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000540348	ENST00000378496	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
Frame-shift	ENST00000540348	ENST00000396787	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
In-frame	ENST00000543944	ENST00000378495	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
In-frame	ENST00000543944	ENST00000378496	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
In-frame	ENST00000543944	ENST00000396787	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
intron-3CDS	ENST00000545103	ENST00000378495	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
intron-3CDS	ENST00000545103	ENST00000378496	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
intron-3CDS	ENST00000545103	ENST00000396787	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+
intron-intron	ENST00000545103	ENST00000481299	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000543944

UBAP1

chr9

34220946

ENST00000396787

UNC13B

chr9

35258990

4820

277

4677

1555

ENST00000543944

UBAP1

chr9

34220946

ENST00000378495

UNC13B

chr9

35258990

5890

277

4584

1524

ENST00000543944

UBAP1

chr9

34220946

ENST00000378496

UNC13B

chr9

35258990

4663

277

4641

1543

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000543944	ENST00000396787	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+	0.001334412	0.9986656
ENST00000543944	ENST00000378495	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+	0.002084703	0.9979153
ENST00000543944	ENST00000378496	UBAP1	chr9	34220946	+	UNC13B	chr9	35258990	+	0.001385483	0.99861455

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Fusion Genomic Features for UBAP1-UNC13B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
UBAP1	chr9	34220946	+	UNC13B	chr9	35258989	+	8.49E-05	0.9999151
UBAP1	chr9	34220946	+	UNC13B	chr9	35258989	+	8.49E-05	0.9999151
UBAP1	chr9	34220946	+	UNC13B	chr9	35258989	+	8.49E-05	0.9999151
UBAP1	chr9	34220946	+	UNC13B	chr9	35258989	+	8.49E-05	0.9999151

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBAP1-UNC13B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:34220946/chr9:35258990)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000543944

17_63

539.0

Domain

UMA

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

1172_1202

156

1592.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

1013_1156

156

1592.0

Domain

MHD1

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

1263_1405

156

1592.0

Domain

MHD2

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

1419_1546

156

1592.0

Domain

C2 3

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

583_707

156

1592.0

Domain

C2 2

Tgene

UNC13B

chr9:34220946

chr9:35258990

ENST00000378495

477_527

156

1592.0

Zinc finger

Phorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000297661

17_63

503.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000297661

389_430

503.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000297661

451_498

503.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000359544

17_63

503.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000359544

389_430

503.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000359544

451_498

503.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000379186

17_63

442.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000379186

389_430

442.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000379186

451_498

442.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000536252

17_63

503.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000536252

389_430

503.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000536252

451_498

503.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000540348

17_63

503.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000540348

389_430

503.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000540348

451_498

503.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000543944

389_430

539.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000543944

451_498

539.0

Domain

UBA 2

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000545103

17_63

567.0

Domain

UMA

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000545103

389_430

567.0

Domain

UBA 1

Hgene

UBAP1

chr9:34220946

chr9:35258990

ENST00000545103

451_498

567.0

Domain

UBA 2

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Fusion Gene Sequence for UBAP1-UNC13B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>95915_95915_1_UBAP1-UNC13B_UBAP1_chr9_34220946_ENST00000543944_UNC13B_chr9_35258990_ENST00000378495_length(transcript)=5890nt_BP=277nt
AGACGCCCAAATGAGTGGGGCGGTGAGGGGAAGGAGGAGGGAAGTAGGACTTCAACATGGCGGCTGCGGCACTGGCGGTGGCTACGGTGA
CGGCCTGGCCCGGAGCGGGCAGAGTTGGAGGTGGTGGCGTTCGCTCTCCCTAGGGGCTGTCGGGAGCTCAGCGGGGACCGAGCCTGGGAG
GCCGGCCGGTGCCAGCACCTTTCGGCTTCTGAGACGGCGGCAGCAGCGGCATTCAGGTTCTAAATGGCTTCTAAGAAGTTGGGTGCAGAT
TTTCATGTATTCTAGTCAAGAAGAAAGCCAGAGGAAGCCATTGCCCACTGCTGCCGCCCAGTGTTCTTTTGAAGACCCTGATAGTGCCGT
CGATGACCGAGATAGTGACTATCGCAGTGAGACCAGCAACAGCTTCCCACCTCCTTACCATACAGCTTCCCAGCCCAACGCTTCTGTGCA
CCAGTTCCCTGTGCCGGTGCGATCGCCACAGCAGCTGCTACTTCAAGGCAGTTCCCGGGACTCTTGTAATGACTCTATGCAAAGTTATGA
CCTTGATTATCCAGAGCGGCGGGCTATCAGCCCCACCAGCAGCAGTAGGTATGGCTCCTCCTGTAATGTGAGTCAAGGAAGCTCTCAGCT
AAGTGAACTAGACCAGTATCACGAACAAGATGACGACCATCGGGAGACGGACTCGATTCATTCTTGCCACAGCTCTCACAGCCTGTCCAG
AGATGGCCAAGCAGGTTTTGGAGAACAAGAGAAACCCTTGGAGGTGACAGGTCAAGCAGAGAAGGAGGCAGCATGTGAACCCAAGGAGAT
GAAAGAAGATGCCACAACCCACCCTCCCCCAGATCTGGTGCTGCAAAAAGACCACTTCCTAGGTCCCCAGGAGAGTTTTCCTGAGGAGAA
TGCATCTTCACCATTTACCCAAGCCAGAGCACATTGGATCCGAGCAGTTACCAAGGTTCGACTCCAGCTGCAGGAGATTCCAGATGATGG
TGACCCCTCTCTGCCTCAGTGGCTCCCGGAAGGGCCAGCCGGAGGGCTCTATGGCATTGACAGCATGCCAGATTTACGCAGAAAGAAGCC
ACTGCCACTTGTCAGTGATCTGTCACTGGTCCAGTCTCGGAAGGCAGGAATCACTTCTGCAATGGCTACACGCACTTCTCTTAAGGACGA
AGAGCTGAAATCCCACGTGTATAAGAAAACCCTGCAGGCCTTAATCTACCCCATTTCGTGCACCACTCCTCATAACTTTGAGGTCTGGAC
GGCCACTACCCCAACCTACTGCTATGAGTGTGAAGGCCTGCTCTGGGGCATTGCCCGGCAGGGCATGCGCTGCAGCGAATGTGGAGTCAA
GTGCCATGAGAAGTGCCAGGATCTGCTCAATGCTGACTGCCTGCAGCGGGCTGCAGAAAAGAGCTGTAAACATGGAGCTGAGGACCGGAC
CCAGAACATTATCATGGCCATGAAGGACCGCATGAAGATCCGAGAGCGAAATAAGCCAGAGATCTTTGAAGTTATCCGGGACGTCTTCAC
AGTGAACAAAGCTGCCCATGTGCAGCAGATGAAAACAGTGAAGCAGAGTGTACTGGATGGCACCTCCAAATGGTCAGCCAAGATCACCAT
TACTGTGGTGTGTGCCCAGGGCCTACAAGCCAAGGACAAAACAGGATCCAGTGACCCTTACGTGACTGTGCAAGTCAGCAAAACTAAGAA
GCGTACCAAGACCATTTTTGGAAACTTGAATCCTGTTTGGGAGGAGAAGTTCCATTTTGAGTGCCACAACTCCTCTGACCGCATTAAGGT
GCGTGTATGGGATGAGGATGATGACATCAAGTCAAGAGTAAAGCAACGCCTAAAGCGAGAGTCTGATGATTTCCTTGGCCAAACCATCAT
TGAGGTTCGGACCCTAAGTGGCGAGATGGACGTCTGGTACAACTTGGAGAAGAGGACAGACAAATCAGCCGTCTCAGGGGCTATCCGACT
ACAAATCAGTGTGGAGATCAAGGGGGAGGAGAAAGTAGCCCCATACCACGTGCAGTATACATGTCTCCATGAGAATCTTTTCCATTACCT
CACAGACATTCAGGGCAGTGGAGGAGTCCGCATCCCTGAAGCTCGAGGAGACGATGCCTGGAAGGTGTACTTTGATGAGACAGCCCAAGA
AATTGTGGATGAATTTGCCATGCGTTATGGCATTGAGTCCATATATCAGGCCATGACGCACTTTGCATGTTTATCATCCAAGTACATGTG
TCCTGGTGTGCCAGCAGTGATGAGCACCTTACTGGCCAACATCAACGCCTACTATGCCCACACAACTGCCTCTACCAATGTCTCTGCATC
TGATCGCTTTGCAGCCTCCAACTTTGGGAAAGAGAGATTTGTAAAACTGCTGGACCAGCTACACAACTCACTGAGGATCGACCTCTCTAC
ATACAGGAATAATTTCCCTGCTGGGAGTCCTGAACGGCTTCAGGACTTAAAATCCACAGTGGATTTGCTGACCAGCATTACTTTCTTCAG
AATGAAGGTACAAGAACTGCAAAGCCCTCCAAGAGCCAGCCAGGTGGTAAAGGATTGTGTGAAGGCCTGTTTGAACTCCACATATGAATA
TATCTTCAACAACTGCCACGACTTATACAGCCGCCAGTACCAGCTGAAGCAGGAGCTACCTCCAGAGGAACAAGGGCCCAGCATTCGGAA
CCTGGATTTCTGGCCCAAGCTCATCACACTCATCGTGTCAATCATAGAGGAAGATAAGAATTCCTACACACCTGTTCTGAACCAGTTTCC
TCAGGAGTTGAATGTGGGAAAAGTCAGCGCAGAAGTGATGTGGCATTTGTTTGCCCAAGACATGAAATATGCATTGGAGGAGCATGAGAA
AGACCACCTGTGTAAAAGTGCTGACTACATGAACCTGCACTTCAAGGTGAAGTGGCTCCACAATGAATACGTGCGGGATCTGCCTGTCCT
CCAGGGGCAGGTGCCTGAGTACCCAGCGTGGTTTGAGCAGTTCGTGCTACAATGGCTGGATGAGAATGAGGATGTATCCCTGGAATTCCT
GCGTGGGGCCCTGGAACGAGATAAGAAGGATGGATTCCAGCAGACATCAGAGCATGCACTCTTTTCCTGCTCTGTGGTGGATGTCTTCAC
ACAACTCAATCAGAGCTTTGAGATCATCCGGAAGCTGGAATGCCCAGACCCCAGCATCCTTGCCCACTACATGAGGAGGTTTGCTAAGAC
CATCGGGAAGGTGCTGATGCAGTATGCAGACATCTTGTCAAAGGACTTCCCAGCCTATTGCACAAAGGAGAAACTGCCCTGCATCCTGAT
GAACAACGTGCAGCAACTGAGGGTCCAGCTGGAGAAAATGTTTGAGGCCATGGGAGGCAAGGAGCTGGACCTTGAAGCTGCAGACAGTCT
GAAGGAGCTGCAGGTGAAACTGAATACGGTTCTGGATGAGCTCAGCATGGTGTTTGGAAACAGTTTCCAGGTACGGATTGATGAGTGTGT
TCGACAAATGGCCGACATCCTGGGCCAGGTTCGGGGCACAGGGAATGCATCTCCAGACGCCAGGGCCTCAGCGGCTCAGGATGCAGATAG
CGTACTCCGGCCTCTCATGGACTTCCTGGATGGCAACCTCACCCTCTTTGCCACTGTGTGTGAGAAGACGGTTCTGAAGCGTGTACTGAA
GGAGCTCTGGCGCGTGGTGATGAACACAATGGAGAGGATGATTGTTCTGCCCCCACTCACTGACCAGACGGGCACCCAGCTGATCTTCAC
TGCTGCCAAGGAGCTGAGCCATCTTTCCAAACTCAAGGATCACATGGTACGAGAGGAAACACGGAATCTCACTCCAAAGCAGTGTGCAGT
CCTTGACCTCGCCCTGGACACCATCAAGCAATACTTCCATGCAGGAGGCAATGGGCTGAAGAAAACCTTCCTGGAGAAGAGCCCAGATCT
GCAGTCTCTACGCTATGCCCTGTCTCTGTACACACAGACTACTGACACTCTCATCAAGACCTTTGTGCGCTCGCAGACCACCCAAGGGTC
TGGTGTGGACGATCCTGTGGGAGAAGTCTCTATTCAGGTGGACTTGTTTACACACCCTGGTACTGGGGAGCACAAGGTCACAGTGAAAGT
GGTGGCTGCCAATGACCTCAAGTGGCAGACAGCGGGTATGTTCCGGCCTTTCGTGGAGGTGACTATGGTTGGCCCACACCAAAGTGATAA
GAAGAGGAAGTTCACAACCAAATCCAAAAGCAACAACTGGGCCCCCAAGTACAATGAGACATTCCACTTCCTCCTGGGAAATGAGGAGGG
GCCCGAGTCCTATGAGTTGCAGATATGCGTGAAGGATTACTGCTTTGCCCGGGAAGATCGCGTGCTAGGGCTGGCTGTGATGCCTCTGAG
GGATGTCACAGCCAAGGGCAGCTGTGCCTGCTGGTGCCCCTTGGGCCGGAAGATCCATATGGATGAGACAGGCCTGACCATTCTCCGGAT
TTTATCTCAGAGGAGCAATGACGAGGTGGCCCGAGAATTTGTGAAACTCAAATCAGAGTCTCGTTCCACGGAGGAGGGGAGCTGAACACC
TTCGACTCCTGTGCCAATCAGGCAGCAGCAATTTCACAAATCAGGGCCAGTGGGAGTTAGCTGTGTAACCGGCTTAGGGTCTTTGCAGTC
AAGAGGCTGACCCCTTCAGTTAAAGATATTTAAGGAAAAATTTGGGGTGGTGATAATATGGCTTTTCACAGAAAGGGTCATGAAGCCCTG
GCCCAACAGGACTGTGGTACTAGGGGCTGGGATGTGGGGTTACCACATGGAGAGATTTTCCATTAAGAGAGAAGGACAAACATTTCTGAG
AGTGTCAGCCATTCTTGGTAGACACCTCTCCACTCCTCATCCCACCTCTACCCATCTCCATGCCACACCTTATCCAGTTAGACACATACA
TACCAATCATTAGAAGAACAAGTTTAGAAGGTGTGGAACTTGTGCCTGGCTGGCTGGGTAGTCAGCTGAGCCTGTTGCTGAGCCCGGTGG
TCTGGATTGGAGTATGGCCAGGGCAGGAGTACACAGAATAGAATTTAGACTGTCCCTTGAGTAGAATCCACTGATTTTCTGTGGCTCCAG
TGAGAACAAGGCTTTGAAACTGAACAAGATAACTTCTAGAAATGAACTGTACTAATCCCTTTCCCCAGATTGTATCATGAGTAGAATCAG
GTTCACGTGGTGCTTCAAAGCCCTGAGAAGAATATTTCTTTGGACCCCAGGCACTAGGGGCCACCTGCCTGGGAGTCTCCCTGCCTCACT
CCTCTAGGCAGGGGAGTGATGCTTCAGGACGTGACAGGCTGTTCTAACATGTGTCTACCTGAGGGCTAGTTGAAGGATCCAGGAGTATTT
TCTTCTTGGGTGGGCCCTGAACAAAGCCAAAAATTGTAGAAACCAGTCTAGAAAAAGTCCTGCTCATCTGTGGCCACTGCCTTCTAGCCG
TCCTCCACCTTGCAGAAAGAATCTAGCCTTTGGTCTCTCTCTCTCTCATCGGGGTCATTTGCTATTCCCCTCTGATATTCAACCCTATAG
AAGGAGCCTGGACTCTGATCCCTCTGTACAGGCTGGATGGAAGGGGCCCTCCACACTTCCTGGGAGGTCAGAGACAAACTGTTTCAGAGA
GTCAGATGGACTTCCCAAGACTTGTTGAGAGATGTGACATGGTTCTTGGATTTCCTCTGTAGCAGCCTCCTGGACTTCCTGAGGACTCGA
CATTGTCCACAGATGTACTGGCCATTACATGAAACAAGAAACCAAGCATCTTTGCTGTTGTTAATTATTATATGTGCCATTGTTACAGGA

>95915_95915_1_UBAP1-UNC13B_UBAP1_chr9_34220946_ENST00000543944_UNC13B_chr9_35258990_ENST00000378495_length(amino acids)=1524AA_BP=87
MSGAVRGRRREVGLQHGGCGTGGGYGDGLARSGQSWRWWRSLSLGAVGSSAGTEPGRPAGASTFRLLRRRQQRHSGSKWLLRSWVQIFMY
SSQEESQRKPLPTAAAQCSFEDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSMQSYDLDY
PERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKED
ATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPL
VSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHE
KCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVV
CAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVR
TLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIVD
EFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRN
NFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSIRNLDF
WPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQ
VPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGK
VLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQM
ADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIFTAAK
ELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQGSGVD
DPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWAPKYNETFHFLLGNEEGPES

--------------------------------------------------------------
>95915_95915_2_UBAP1-UNC13B_UBAP1_chr9_34220946_ENST00000543944_UNC13B_chr9_35258990_ENST00000378496_length(transcript)=4663nt_BP=277nt
AGACGCCCAAATGAGTGGGGCGGTGAGGGGAAGGAGGAGGGAAGTAGGACTTCAACATGGCGGCTGCGGCACTGGCGGTGGCTACGGTGA
CGGCCTGGCCCGGAGCGGGCAGAGTTGGAGGTGGTGGCGTTCGCTCTCCCTAGGGGCTGTCGGGAGCTCAGCGGGGACCGAGCCTGGGAG
GCCGGCCGGTGCCAGCACCTTTCGGCTTCTGAGACGGCGGCAGCAGCGGCATTCAGGTTCTAAATGGCTTCTAAGAAGTTGGGTGCAGAT
TTTCATGTATTCTAGTCAAGAAGAAAGCCAGAGGAAGCCATTGCCCACTGCTGCCGCCCAGTGTTCTTTTGAAGACCCTGATAGTGCCGT
CGATGACCGAGATAGTGACTATCGCAGTGAGACCAGCAACAGCTTCCCACCTCCTTACCATACAGCTTCCCAGCCCAACGCTTCTGTGCA
CCAGTTCCCTGTGCCGGTGCGATCGCCACAGCAGCTGCTACTTCAAGGCAGTTCCCGGGACTCTTGTAATGACTCTATGCAAAGTTATGA
CCTTGATTATCCAGAGCGGCGGGCTATCAGCCCCACCAGCAGCAGTAGGTATGGCTCCTCCTGTAATGTGAGTCAAGGAAGCTCTCAGCT
AAGTGAACTAGACCAGTATCACGAACAAGATGACGACCATCGGGAGACGGACTCGATTCATTCTTGCCACAGCTCTCACAGCCTGTCCAG
AGATGGCCAAGCAGGTTTTGGAGAACAAGAGAAACCCTTGGAGGTGACAGGTCAAGCAGAGAAGGAGGCAGCATGTGAACCCAAGGAGAT
GAAAGAAGATGCCACAACCCACCCTCCCCCAGATCTGGTGCTGCAAAAAGACCACTTCCTAGGTCCCCAGGAGAGTTTTCCTGAGGAGAA
TGCATCTTCACCATTTACCCAAGCCAGAGCACATTGGATCCGAGCAGTTACCAAGGTTCGACTCCAGCTGCAGGAGATTCCAGATGATGG
TGACCCCTCTCTGCCTCAGTGGCTCCCGGAAGGGCCAGCCGGAGGGCTCTATGGCATTGACAGCATGCCAGATTTACGCAGAAAGAAGCC
ACTGCCACTTGTCAGTGATCTGTCACTGGTCCAGTCTCGGAAGGCAGGAATCACTTCTGCAATGGCTACACGCACTTCTCTTAAGGACGA
AGAGCTGAAATCCCACGTGTATAAGAAAACCCTGCAGGCCTTAATCTACCCCATTTCGTGCACCACTCCTCATAACTTTGAGGTCTGGAC
GGCCACTACCCCAACCTACTGCTATGAGTGTGAAGGCCTGCTCTGGGGCATTGCCCGGCAGGGCATGCGCTGCAGCGAATGTGGAGTCAA
GTGCCATGAGAAGTGCCAGGATCTGCTCAATGCTGACTGCCTGCAGCGGGCTGCAGAAAAGAGCTGTAAACATGGAGCTGAGGACCGGAC
CCAGAACATTATCATGGCCATGAAGGACCGCATGAAGATCCGAGAGCGAAATAAGCCAGAGATCTTTGAAGTTATCCGGGACGTCTTCAC
AGTGAACAAAGCTGCCCATGTGCAGCAGATGAAAACAGTGAAGCAGAGTGTACTGGATGGCACCTCCAAATGGTCAGCCAAGATCACCAT
TACTGTGGTGTGTGCCCAGGGCCTACAAGCCAAGGACAAAACAGGATCCAGTGACCCTTACGTGACTGTGCAAGTCAGCAAAACTAAGAA
GCGTACCAAGACCATTTTTGGAAACTTGAATCCTGTTTGGGAGGAGAAGTTCCATTTTGAGTGCCACAACTCCTCTGACCGCATTAAGGT
GCGTGTATGGGATGAGGATGATGACATCAAGTCAAGAGTAAAGCAACGCCTAAAGCGAGAGTCTGATGATTTCCTTGGCCAAACCATCAT
TGAGGTTCGGACCCTAAGTGGCGAGATGGACGTCTGGTACAACTTGGAGAAGAGGACAGACAAATCAGCCGTCTCAGGGGCTATCCGACT
ACAAATCAGTGTGGAGATCAAGGGGGAGGAGAAAGTAGCCCCATACCACGTGCAGTATACATGTCTCCATGAGAATCTTTTCCATTACCT
CACAGACATTCAGGGCAGTGGAGGAGTCCGCATCCCTGAAGCTCGAGGAGACGATGCCTGGAAGGTGTACTTTGATGAGACAGCCCAAGA
AATTGTGGATGAATTTGCCATGCGTTATGGCATTGAGTCCATATATCAGGCCATGACGCACTTTGCATGTTTATCATCCAAGTACATGTG
TCCTGGTGTGCCAGCAGTGATGAGCACCTTACTGGCCAACATCAACGCCTACTATGCCCACACAACTGCCTCTACCAATGTCTCTGCATC
TGATCGCTTTGCAGCCTCCAACTTTGGGAAAGAGAGATTTGTAAAACTGCTGGACCAGCTACACAACTCACTGAGGATCGACCTCTCTAC
ATACAGGAATAATTTCCCTGCTGGGAGTCCTGAACGGCTTCAGGACTTAAAATCCACAGTGGATTTGCTGACCAGCATTACTTTCTTCAG
AATGAAGGTACAAGAACTGCAAAGCCCTCCAAGAGCCAGCCAGGTGGTAAAGGATTGTGTGAAGGCCTGTTTGAACTCCACATATGAATA
TATCTTCAACAACTGCCACGACTTATACAGCCGCCAGTACCAGCTGAAGCAGGAGCTACCTCCAGAGGAACAAGGGCCCAGCATTCGGAA
CCTGGATTTCTGGCCCAAGCTCATCACACTCATCGTGTCAATCATAGAGGAAGATAAGAATTCCTACACACCTGTTCTGAACCAGTTTCC
TCAGGAGTTGAATGTGGGAAAAGTCAGCGCAGAAGTGATGTGGCATTTGTTTGCCCAAGACATGAAATATGCATTGGAGGAGCATGAGAA
AGACCACCTGTGTAAAAGTGCTGACTACATGAACCTGCACTTCAAGGTGAAGTGGCTCCACAATGAATACGTGCGGGATCTGCCTGTCCT
CCAGGGGCAGGTGCCTGAGTACCCAGCGTGGTTTGAGCAGTTCGTGCTACAATGGCTGGATGAGAATGAGGATGTATCCCTGGAATTCCT
GCGTGGGGCCCTGGAACGAGATAAGAAGGATGGATTCCAGCAGACATCAGAGCATGCACTCTTTTCCTGCTCTGTGGTGGATGTCTTCAC
ACAACTCAATCAGAGCTTTGAGATCATCCGGAAGCTGGAATGCCCAGACCCCAGCATCCTTGCCCACTACATGAGGAGGTTTGCTAAGAC
CATCGGGAAGGTGCTGATGCAGTATGCAGACATCTTGTCAAAGGACTTCCCAGCCTATTGCACAAAGGAGAAACTGCCCTGCATCCTGAT
GAACAACGTGCAGCAACTGAGGGTCCAGCTGGAGAAAATGTTTGAGGCCATGGGAGGCAAGGAGCTGGACCTTGAAGCTGCAGACAGTCT
GAAGGAGCTGCAGGTGAAACTGAATACGGTTCTGGATGAGCTCAGCATGGTGTTTGGAAACAGTTTCCAGGTACGGATTGATGAGTGTGT
TCGACAAATGGCCGACATCCTGGGCCAGGTTCGGGGCACAGGGAATGCATCTCCAGACGCCAGGGCCTCAGCGGCTCAGGATGCAGATAG
CGTACTCCGGCCTCTCATGGACTTCCTGGATGGCAACCTCACCCTCTTTGCCACTGTGTGTGAGAAGACGGTTCTGAAGCGTGTACTGAA
GGAGCTCTGGCGCGTGGTGATGAACACAATGGAGAGGATGATTGTTCTGCCCCCACTCACTGACCAGACGGGCACCCAGCTGATCTTCAC
TGCTGCCAAGGAGCTGAGCCATCTTTCCAAACTCAAGGATCACATGGTACGAGAGGAAACACGGAATCTCACTCCAAAGCAGTGTGCAGT
CCTTGACCTCGCCCTGGACACCATCAAGCAATACTTCCATGCAGGAGGCAATGGGCTGAAGAAAACCTTCCTGGAGAAGAGCCCAGATCT
GCAGTCTCTACGCTATGCCCTGTCTCTGTACACACAGACTACTGACACTCTCATCAAGACCTTTGTGCGCTCGCAGACCACCCAAGTGCA
TGATGGGAAAGGTATTAGATTTACTGCTAATGAGGACATTCGTCCGGAAAAGGGGTCTGGTGTGGACGATCCTGTGGGAGAAGTCTCTAT
TCAGGTGGACTTGTTTACACACCCTGGTACTGGGGAGCACAAGGTCACAGTGAAAGTGGTGGCTGCCAATGACCTCAAGTGGCAGACAGC
GGGTATGTTCCGGCCTTTCGTGGAGGTGACTATGGTTGGCCCACACCAAAGTGATAAGAAGAGGAAGTTCACAACCAAATCCAAAAGCAA
CAACTGGGCCCCCAAGTACAATGAGACATTCCACTTCCTCCTGGGAAATGAGGAGGGGCCCGAGTCCTATGAGTTGCAGATATGCGTGAA
GGATTACTGCTTTGCCCGGGAAGATCGCGTGCTAGGGCTGGCTGTGATGCCTCTGAGGGATGTCACAGCCAAGGGCAGCTGTGCCTGCTG
GTGCCCCTTGGGCCGGAAGATCCATATGGATGAGACAGGCCTGACCATTCTCCGGATTTTATCTCAGAGGAGCAATGACGAGGTGGCCCG

>95915_95915_2_UBAP1-UNC13B_UBAP1_chr9_34220946_ENST00000543944_UNC13B_chr9_35258990_ENST00000378496_length(amino acids)=1543AA_BP=87
MSGAVRGRRREVGLQHGGCGTGGGYGDGLARSGQSWRWWRSLSLGAVGSSAGTEPGRPAGASTFRLLRRRQQRHSGSKWLLRSWVQIFMY
SSQEESQRKPLPTAAAQCSFEDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDSCNDSMQSYDLDY
PERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEKEAACEPKEMKED
ATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDSMPDLRRKKPLPL
VSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCSECGVKCHE
KCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGTSKWSAKITITVV
CAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVR
TLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWKVYFDETAQEIVD
EFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSTYRN
NFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPPEEQGPSIRNLDF
WPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHNEYVRDLPVLQGQ
VPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILAHYMRRFAKTIGK
VLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNSFQVRIDECVRQM
ADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTDQTGTQLIFTAAK
ELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTFVRSQTTQVHDGK
GIRFTANEDIRPEKGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKRKFTTKSKSNNWA
PKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILSQRSNDEVAREFV

--------------------------------------------------------------
>95915_95915_3_UBAP1-UNC13B_UBAP1_chr9_34220946_ENST00000543944_UNC13B_chr9_35258990_ENST00000396787_length(transcript)=4820nt_BP=277nt
AGACGCCCAAATGAGTGGGGCGGTGAGGGGAAGGAGGAGGGAAGTAGGACTTCAACATGGCGGCTGCGGCACTGGCGGTGGCTACGGTGA
CGGCCTGGCCCGGAGCGGGCAGAGTTGGAGGTGGTGGCGTTCGCTCTCCCTAGGGGCTGTCGGGAGCTCAGCGGGGACCGAGCCTGGGAG
GCCGGCCGGTGCCAGCACCTTTCGGCTTCTGAGACGGCGGCAGCAGCGGCATTCAGGTTCTAAATGGCTTCTAAGAAGTTGGGTGCAGAT
TTTCATGTATTCTAGTCAAGAAGAAAGCCAGAGGAAGCCATTGCCCACTGCTGCCGCCCAGTGTTGTCACTGGACCTATTTGGGCTGGGG
AGAACAACAGACTTTTGAAGACCCTGATAGTGCCGTCGATGACCGAGATAGTGACTATCGCAGTGAGACCAGCAACAGCTTCCCACCTCC
TTACCATACAGCTTCCCAGCCCAACGCTTCTGTGCACCAGTTCCCTGTGCCGGTGCGATCGCCACAGCAGCTGCTACTTCAAGGCAGTTC
CCGGGACTCTTGTAATGACTCTATGCAAAGTTATGACCTTGATTATCCAGAGCGGCGGGCTATCAGCCCCACCAGCAGCAGTAGGTATGG
CTCCTCCTGTAATGTGAGTCAAGGAAGCTCTCAGCTAAGTGAACTAGACCAGTATCACGAACAAGATGACGACCATCGGGAGACGGACTC
GATTCATTCTTGCCACAGCTCTCACAGCCTGTCCAGAGATGGCCAAGCAGGTTTTGGAGAACAAGAGAAACCCTTGGAGGTGACAGGTCA
AGCAGAGAAGGAGGCAGCATGTGAACCCAAGGAGATGAAAGAAGATGCCACAACCCACCCTCCCCCAGATCTGGTGCTGCAAAAAGACCA
CTTCCTAGGTCCCCAGGAGAGTTTTCCTGAGGAGAATGCATCTTCACCATTTACCCAAGCCAGAGCACATTGGATCCGAGCAGTTACCAA
GGTTCGACTCCAGCTGCAGGAGATTCCAGATGATGGTGACCCCTCTCTGCCTCAGTGGCTCCCGGAAGGGCCAGCCGGAGGGCTCTATGG
CATTGACAGCATGCCAGATTTACGCAGAAAGAAGCCACTGCCACTTGTCAGTGATCTGTCACTGGTCCAGTCTCGGAAGGCAGGAATCAC
TTCTGCAATGGCTACACGCACTTCTCTTAAGGACGAAGAGCTGAAATCCCACGTGTATAAGAAAACCCTGCAGGCCTTAATCTACCCCAT
TTCGTGCACCACTCCTCATAACTTTGAGGTCTGGACGGCCACTACCCCAACCTACTGCTATGAGTGTGAAGGCCTGCTCTGGGGCATTGC
CCGGCAGGGCATGCGCTGCAGCGAATGTGGAGTCAAGTGCCATGAGAAGTGCCAGGATCTGCTCAATGCTGACTGCCTGCAGCGGGCTGC
AGAAAAGAGCTGTAAACATGGAGCTGAGGACCGGACCCAGAACATTATCATGGCCATGAAGGACCGCATGAAGATCCGAGAGCGAAATAA
GCCAGAGATCTTTGAAGTTATCCGGGACGTCTTCACAGTGAACAAAGCTGCCCATGTGCAGCAGATGAAAACAGTGAAGCAGAGTGTACT
GGATGGCACCTCCAAATGGTCAGCCAAGATCACCATTACTGTGGTGTGTGCCCAGGGCCTACAAGCCAAGGACAAAACAGGATCCAGTGA
CCCTTACGTGACTGTGCAAGTCAGCAAAACTAAGAAGCGTACCAAGACCATTTTTGGAAACTTGAATCCTGTTTGGGAGGAGAAGTTCCA
TTTTGAGTGCCACAACTCCTCTGACCGCATTAAGGTGCGTGTATGGGATGAGGATGATGACATCAAGTCAAGAGTAAAGCAACGCCTAAA
GCGAGAGTCTGATGATTTCCTTGGCCAAACCATCATTGAGGTTCGGACCCTAAGTGGCGAGATGGACGTCTGGTACAACTTGGAGAAGAG
GACAGACAAATCAGCCGTCTCAGGGGCTATCCGACTACAAATCAGTGTGGAGATCAAGGGGGAGGAGAAAGTAGCCCCATACCACGTGCA
GTATACATGTCTCCATGAGAATCTTTTCCATTACCTCACAGACATTCAGGGCAGTGGAGGAGTCCGCATCCCTGAAGCTCGAGGAGACGA
TGCCTGGAAGGTGTACTTTGATGAGACAGCCCAAGAAATTGTGGATGAATTTGCCATGCGTTATGGCATTGAGTCCATATATCAGGCCAT
GACGCACTTTGCATGTTTATCATCCAAGTACATGTGTCCTGGTGTGCCAGCAGTGATGAGCACCTTACTGGCCAACATCAACGCCTACTA
TGCCCACACAACTGCCTCTACCAATGTCTCTGCATCTGATCGCTTTGCAGCCTCCAACTTTGGGAAAGAGAGATTTGTAAAACTGCTGGA
CCAGCTACACAACTCACTGAGGATCGACCTCTCTACATACAGGAATAATTTCCCTGCTGGGAGTCCTGAACGGCTTCAGGACTTAAAATC
CACAGTGGATTTGCTGACCAGCATTACTTTCTTCAGAATGAAGGTACAAGAACTGCAAAGCCCTCCAAGAGCCAGCCAGGTGGTAAAGGA
TTGTGTGAAGGCCTGTTTGAACTCCACATATGAATATATCTTCAACAACTGCCACGACTTATACAGCCGCCAGTACCAGCTGAAGCAGGA
GCTACCTCCAGAGGAACAAGGGCCCAGCATTCGGAACCTGGATTTCTGGCCCAAGCTCATCACACTCATCGTGTCAATCATAGAGGAAGA
TAAGAATTCCTACACACCTGTTCTGAACCAGTTTCCTCAGGAGTTGAATGTGGGAAAAGTCAGCGCAGAAGTGATGTGGCATTTGTTTGC
CCAAGACATGAAATATGCATTGGAGGAGCATGAGAAAGACCACCTGTGTAAAAGTGCTGACTACATGAACCTGCACTTCAAGGTGAAGTG
GCTCCACAATGAATACGTGCGGGATCTGCCTGTCCTCCAGGGGCAGGTGCCTGAGTACCCAGCGTGGTTTGAGCAGTTCGTGCTACAATG
GCTGGATGAGAATGAGGATGTATCCCTGGAATTCCTGCGTGGGGCCCTGGAACGAGATAAGAAGGATGGATTCCAGCAGACATCAGAGCA
TGCACTCTTTTCCTGCTCTGTGGTGGATGTCTTCACACAACTCAATCAGAGCTTTGAGATCATCCGGAAGCTGGAATGCCCAGACCCCAG
CATCCTTGCCCACTACATGAGGAGGTTTGCTAAGACCATCGGGAAGGTGCTGATGCAGTATGCAGACATCTTGTCAAAGGACTTCCCAGC
CTATTGCACAAAGGAGAAACTGCCCTGCATCCTGATGAACAACGTGCAGCAACTGAGGGTCCAGCTGGAGAAAATGTTTGAGGCCATGGG
AGGCAAGGAGCTGGACCTTGAAGCTGCAGACAGTCTGAAGGAGCTGCAGGTGAAACTGAATACGGTTCTGGATGAGCTCAGCATGGTGTT
TGGAAACAGTTTCCAGGTACGGATTGATGAGTGTGTTCGACAAATGGCCGACATCCTGGGCCAGGTTCGGGGCACAGGGAATGCATCTCC
AGACGCCAGGGCCTCAGCGGCTCAGGATGCAGATAGCGTACTCCGGCCTCTCATGGACTTCCTGGATGGCAACCTCACCCTCTTTGCCAC
TGTGTGTGAGAAGACGGTTCTGAAGCGTGTACTGAAGGAGCTCTGGCGCGTGGTGATGAACACAATGGAGAGGATGATTGTTCTGCCCCC
ACTCACTGACCAGACGGGCACCCAGCTGATCTTCACTGCTGCCAAGGAGCTGAGCCATCTTTCCAAACTCAAGGATCACATGGTACGAGA
GGAAACACGGAATCTCACTCCAAAGCAGTGTGCAGTCCTTGACCTCGCCCTGGACACCATCAAGCAATACTTCCATGCAGGAGGCAATGG
GCTGAAGAAAACCTTCCTGGAGAAGAGCCCAGATCTGCAGTCTCTACGCTATGCCCTGTCTCTGTACACACAGACTACTGACACTCTCAT
CAAGACCTTTGTGCGCTCGCAGACCACCCAAGTGCATGATGGGAAAGGTATTAGATTTACTGCTAATGAGGACATTCGTCCGGAAAAGGG
GTCTGGTGTGGACGATCCTGTGGGAGAAGTCTCTATTCAGGTGGACTTGTTTACACACCCTGGTACTGGGGAGCACAAGGTCACAGTGAA
AGTGGTGGCTGCCAATGACCTCAAGTGGCAGACAGCGGGTATGTTCCGGCCTTTCGTGGAGGTGACTATGGTTGGCCCACACCAAAGTGA
TAAGAAGAGGAAGTTCACAACCAAATCCAAAAGCAACAACTGGGCCCCCAAGTACAATGAGACATTCCACTTCCTCCTGGGAAATGAGGA
GGGGCCCGAGTCCTATGAGTTGCAGATATGCGTGAAGGATTACTGCTTTGCCCGGGAAGATCGCGTGCTAGGGCTGGCTGTGATGCCTCT
GAGGGATGTCACAGCCAAGGGCAGCTGTGCCTGCTGGTGCCCCTTGGGCCGGAAGATCCATATGGATGAGACAGGCCTGACCATTCTCCG
GATTTTATCTCAGAGGAGCAATGACGAGGTGGCCCGAGAATTTGTGAAACTCAAATCAGAGTCTCGTTCCACGGAGGAGGGGAGCTGAAC
ACCTTCGACTCCTGTGCCAATCAGGCAGCAGCAATTTCACAAATCAGGGCCAGTGGGAGTTAGCTGTGTAACCGGCTTAGGGTCTTTGCA

>95915_95915_3_UBAP1-UNC13B_UBAP1_chr9_34220946_ENST00000543944_UNC13B_chr9_35258990_ENST00000396787_length(amino acids)=1555AA_BP=87
MSGAVRGRRREVGLQHGGCGTGGGYGDGLARSGQSWRWWRSLSLGAVGSSAGTEPGRPAGASTFRLLRRRQQRHSGSKWLLRSWVQIFMY
SSQEESQRKPLPTAAAQCCHWTYLGWGEQQTFEDPDSAVDDRDSDYRSETSNSFPPPYHTASQPNASVHQFPVPVRSPQQLLLQGSSRDS
CNDSMQSYDLDYPERRAISPTSSSRYGSSCNVSQGSSQLSELDQYHEQDDDHRETDSIHSCHSSHSLSRDGQAGFGEQEKPLEVTGQAEK
EAACEPKEMKEDATTHPPPDLVLQKDHFLGPQESFPEENASSPFTQARAHWIRAVTKVRLQLQEIPDDGDPSLPQWLPEGPAGGLYGIDS
MPDLRRKKPLPLVSDLSLVQSRKAGITSAMATRTSLKDEELKSHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQG
MRCSECGVKCHEKCQDLLNADCLQRAAEKSCKHGAEDRTQNIIMAMKDRMKIRERNKPEIFEVIRDVFTVNKAAHVQQMKTVKQSVLDGT
SKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDRIKVRVWDEDDDIKSRVKQRLKRES
DDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLQISVEIKGEEKVAPYHVQYTCLHENLFHYLTDIQGSGGVRIPEARGDDAWK
VYFDETAQEIVDEFAMRYGIESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLH
NSLRIDLSTYRNNFPAGSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHDLYSRQYQLKQELPP
EEQGPSIRNLDFWPKLITLIVSIIEEDKNSYTPVLNQFPQELNVGKVSAEVMWHLFAQDMKYALEEHEKDHLCKSADYMNLHFKVKWLHN
EYVRDLPVLQGQVPEYPAWFEQFVLQWLDENEDVSLEFLRGALERDKKDGFQQTSEHALFSCSVVDVFTQLNQSFEIIRKLECPDPSILA
HYMRRFAKTIGKVLMQYADILSKDFPAYCTKEKLPCILMNNVQQLRVQLEKMFEAMGGKELDLEAADSLKELQVKLNTVLDELSMVFGNS
FQVRIDECVRQMADILGQVRGTGNASPDARASAAQDADSVLRPLMDFLDGNLTLFATVCEKTVLKRVLKELWRVVMNTMERMIVLPPLTD
QTGTQLIFTAAKELSHLSKLKDHMVREETRNLTPKQCAVLDLALDTIKQYFHAGGNGLKKTFLEKSPDLQSLRYALSLYTQTTDTLIKTF
VRSQTTQVHDGKGIRFTANEDIRPEKGSGVDDPVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTAGMFRPFVEVTMVGPHQSDKKR
KFTTKSKSNNWAPKYNETFHFLLGNEEGPESYELQICVKDYCFAREDRVLGLAVMPLRDVTAKGSCACWCPLGRKIHMDETGLTILRILS

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Fusion Gene PPI Analysis for UBAP1-UNC13B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000297661	+	2	7	1_95	11.333333333333334	503.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000359544	+	2	7	1_95	11.333333333333334	503.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000379186	+	2	6	1_95	11.333333333333334	442.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000536252	+	3	8	1_95	11.333333333333334	503.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000540348	+	3	8	1_95	11.333333333333334	503.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000543944	+	2	6	1_95	89.0	539.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000545103	+	1	6	1_95	0	567.0	ESCRT-I
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000297661	+	2	7	260_290	11.333333333333334	503.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000359544	+	2	7	260_290	11.333333333333334	503.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000379186	+	2	6	260_290	11.333333333333334	442.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000536252	+	3	8	260_290	11.333333333333334	503.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000540348	+	3	8	260_290	11.333333333333334	503.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000543944	+	2	6	260_290	89.0	539.0	PTPN23
Hgene	UBAP1	chr9:34220946	chr9:35258990	ENST00000545103	+	1	6	260_290	0	567.0	PTPN23

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for UBAP1-UNC13B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for UBAP1-UNC13B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source