FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:UBB-SLC15A2 (FusionGDB2 ID:95964)

Fusion Gene Summary for UBB-SLC15A2

check button Fusion gene summary
Fusion gene informationFusion gene name: UBB-SLC15A2
Fusion gene ID: 95964
HgeneTgene
Gene symbol

UBB

SLC15A2

Gene ID

7314

6565

Gene nameubiquitin Bsolute carrier family 15 member 2
SynonymsHEL-S-50PEPT2
Cytomap

17p11.2

3q13.33

Type of geneprotein-codingprotein-coding
Descriptionpolyubiquitin-Bepididymis secretory protein Li 50polyubiquitin Bsolute carrier family 15 member 2kidney H(+)/peptide cotransporteroligopeptide transporter, kidney isoformpeptide transporter 2solute carrier family 15 (H+/peptide transporter), member 2solute carrier family 15 (oligopeptide transporter), member 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000578649, ENST00000302182, 
ENST00000395837, ENST00000395839, 
ENST00000535788, 		ENST00000295605, 
ENST00000489711, ENST00000465060, 
Fusion gene scores* DoF score7 X 8 X 3=1684 X 3 X 2=24
# samples 93
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBB [Title/Abstract] AND SLC15A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBB(16285728)-SLC15A2(121659775), # samples:1
Anticipated loss of major functional domain due to fusion event.UBB-SLC15A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
UBB-SLC15A2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBB

GO:0031398

positive regulation of protein ubiquitination

24660806

HgeneUBB

GO:0047497

mitochondrion transport along microtubule

17571083

HgeneUBB

GO:0051881

regulation of mitochondrial membrane potential

17571083

HgeneUBB

GO:0061136

regulation of proteasomal protein catabolic process

17571083

HgeneUBB

GO:1901214

regulation of neuron death

17571083

HgeneUBB

GO:1902255

positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

17571083


check buttonFusion gene breakpoints across UBB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC15A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA451552UBBchr17

16285728

+SLC15A2chr3

121659775

+


Top

Fusion Gene ORF analysis for UBB-SLC15A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000578649ENST00000295605UBBchr17

16285728

+SLC15A2chr3

121659775

+
3UTR-3CDSENST00000578649ENST00000489711UBBchr17

16285728

+SLC15A2chr3

121659775

+
3UTR-intronENST00000578649ENST00000465060UBBchr17

16285728

+SLC15A2chr3

121659775

+
5CDS-intronENST00000302182ENST00000465060UBBchr17

16285728

+SLC15A2chr3

121659775

+
5CDS-intronENST00000395837ENST00000465060UBBchr17

16285728

+SLC15A2chr3

121659775

+
5CDS-intronENST00000395839ENST00000465060UBBchr17

16285728

+SLC15A2chr3

121659775

+
5CDS-intronENST00000535788ENST00000465060UBBchr17

16285728

+SLC15A2chr3

121659775

+
Frame-shiftENST00000302182ENST00000295605UBBchr17

16285728

+SLC15A2chr3

121659775

+
Frame-shiftENST00000302182ENST00000489711UBBchr17

16285728

+SLC15A2chr3

121659775

+
Frame-shiftENST00000395837ENST00000295605UBBchr17

16285728

+SLC15A2chr3

121659775

+
Frame-shiftENST00000395837ENST00000489711UBBchr17

16285728

+SLC15A2chr3

121659775

+
Frame-shiftENST00000395839ENST00000295605UBBchr17

16285728

+SLC15A2chr3

121659775

+
Frame-shiftENST00000395839ENST00000489711UBBchr17

16285728

+SLC15A2chr3

121659775

+
In-frameENST00000535788ENST00000295605UBBchr17

16285728

+SLC15A2chr3

121659775

+
In-frameENST00000535788ENST00000489711UBBchr17

16285728

+SLC15A2chr3

121659775

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535788UBBchr1716285728+ENST00000489711SLC15A2chr3121659775+382264830312561156
ENST00000535788UBBchr1716285728+ENST00000295605SLC15A2chr3121659775+972648544227105

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535788ENST00000489711UBBchr1716285728+SLC15A2chr3121659775+0.033969550.9660304
ENST00000535788ENST00000295605UBBchr1716285728+SLC15A2chr3121659775+0.0658422560.9341578

Top

Fusion Genomic Features for UBB-SLC15A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for UBB-SLC15A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:16285728/chr3:121659775)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021402_6110699.0RegionExtracellular domain (ECD)
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022402_6110730.0RegionExtracellular domain (ECD)
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021105_1130699.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021135_1390699.0Topological domainExtracellular
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021161_1830699.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST000002956050211_570699.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021205_2170699.0Topological domainExtracellular
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021239_2950699.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021317_3430699.0Topological domainExtracellular
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021365_3800699.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021633_6430699.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021665_6740699.0Topological domainExtracellular
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021696_7290699.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST0000029560502179_830699.0Topological domainExtracellular
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022105_1130730.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022135_1390730.0Topological domainExtracellular
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022161_1830730.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST000004897110221_570730.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022205_2170730.0Topological domainExtracellular
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022239_2950730.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022317_3430730.0Topological domainExtracellular
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022365_3800730.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022633_6430730.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022665_6740730.0Topological domainExtracellular
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022696_7290730.0Topological domainCytoplasmic
TgeneSLC15A2chr17:16285728chr3:121659775ENST0000048971102279_830730.0Topological domainExtracellular
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021114_1340699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021140_1600699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021184_2040699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021218_2380699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021296_3160699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021344_3640699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021381_4010699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST0000029560502158_780699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021612_6320699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021644_6640699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000295605021675_6950699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST0000029560502184_1040699.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022114_1340730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022140_1600730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022184_2040730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022218_2380730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022296_3160730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022344_3640730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022381_4010730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST0000048971102258_780730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022612_6320730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022644_6640730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST00000489711022675_6950730.0TransmembraneHelical
TgeneSLC15A2chr17:16285728chr3:121659775ENST0000048971102284_1040730.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBBchr17:16285728chr3:121659775ENST00000302182+12153_2280230.0DomainUbiquitin-like 3
HgeneUBBchr17:16285728chr3:121659775ENST00000302182+121_760230.0DomainUbiquitin-like 1
HgeneUBBchr17:16285728chr3:121659775ENST00000302182+1277_1520230.0DomainUbiquitin-like 2
HgeneUBBchr17:16285728chr3:121659775ENST00000395837+12153_2280230.0DomainUbiquitin-like 3
HgeneUBBchr17:16285728chr3:121659775ENST00000395837+121_760230.0DomainUbiquitin-like 1
HgeneUBBchr17:16285728chr3:121659775ENST00000395837+1277_1520230.0DomainUbiquitin-like 2
HgeneUBBchr17:16285728chr3:121659775ENST00000395839+12153_2280230.0DomainUbiquitin-like 3
HgeneUBBchr17:16285728chr3:121659775ENST00000395839+121_760230.0DomainUbiquitin-like 1
HgeneUBBchr17:16285728chr3:121659775ENST00000395839+1277_1520230.0DomainUbiquitin-like 2


Top

Fusion Gene Sequence for UBB-SLC15A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>95964_95964_1_UBB-SLC15A2_UBB_chr17_16285728_ENST00000535788_SLC15A2_chr3_121659775_ENST00000295605_length(transcript)=972nt_BP=648nt
ATTTAGGGGCGGTTGGCTTTGTTGGGTGAGCTTGTTTGTGTCCCTGTGGGTGGACGTGGTTGGTGATTGGCAGGATCCTGGTATCCGCTA
ACAGGTCAAAATGCAGATCTTCGTGAAAACCCTTACCGGCAAGACCATCACCCTTGAGGTGGAGCCCAGTGACACCATCGAAAATGTGAA
GGCCAAGATCCAGGATAAGGAAGGCATTCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGTACTCTTTC
TGACTACAACATCCAGAAGGAGTCGACCCTGCACCTGGTCCTGCGTCTGAGAGGAGCCCAGTGACACCATCGAAAATGTGAAGGCCAAGA
TCCAAGATAAAGAAGGCATCCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCTGACTACA
ACATCCAGAAAGAGTCGACCCTGCACCTGGTCCTGCGCCTGAGGGGTGGCTGTTAATTCTTCAGTCATGGCATTCGCAGTGCCCAGTGAT
GGCATTACTCTGCACTATAGCCATTTGCCCCAACTTAAGTTTAGAAATTACAAGTTTCAGTAATAGCTGAACCTGTTCAAAATGTTAATA
AAGGTTTCGTTGCATGGTGCGGGGTCCAGCAGATAAGCACATTCCTCACATCCAGGGGAACATGATCAAACTAGAGACCAAGAAGACAAA
ACTCTGATGACTCCCTAGATTCTGTCCTGACCCCAATTCCTGGCCCTGTCTTGAAGCATTTTTTTTCTTCTACTGGATTAGACAAGAGAG
ATAGCAGCATATCAGAGCTGATCTCCTCCACCTTTCTCCAATGACAGAAGTTCCAGGACTGGTTTTCCAGTACATCTTTAAACAAGGCCC

>95964_95964_1_UBB-SLC15A2_UBB_chr17_16285728_ENST00000535788_SLC15A2_chr3_121659775_ENST00000295605_length(amino acids)=105AA_BP=
MPSLGTANAMTEELTATPQAQDQVQGRLFLDVVVRKSAAIFQLLACKDEPLLVGGDAFFILDLGLHIFDGVTGLLSDAGPGAGSTPSGCC

--------------------------------------------------------------
>95964_95964_2_UBB-SLC15A2_UBB_chr17_16285728_ENST00000535788_SLC15A2_chr3_121659775_ENST00000489711_length(transcript)=3822nt_BP=648nt
ATTTAGGGGCGGTTGGCTTTGTTGGGTGAGCTTGTTTGTGTCCCTGTGGGTGGACGTGGTTGGTGATTGGCAGGATCCTGGTATCCGCTA
ACAGGTCAAAATGCAGATCTTCGTGAAAACCCTTACCGGCAAGACCATCACCCTTGAGGTGGAGCCCAGTGACACCATCGAAAATGTGAA
GGCCAAGATCCAGGATAAGGAAGGCATTCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGTACTCTTTC
TGACTACAACATCCAGAAGGAGTCGACCCTGCACCTGGTCCTGCGTCTGAGAGGAGCCCAGTGACACCATCGAAAATGTGAAGGCCAAGA
TCCAAGATAAAGAAGGCATCCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCTGACTACA
ACATCCAGAAAGAGTCGACCCTGCACCTGGTCCTGCGCCTGAGGGGTGGCTGTTAATTCTTCAGTCATGGCATTCGCAGTGCCCAGTGAT
GGCATTACTCTGCACTATAGCCATTTGCCCCAACTTAAGTTTAGAAATTACAAGTTTCAGTAATAGCTGAACCTGTTCAAAATGTTAATA
AAGGTTTCGTTGCATGGTGCGGGGTCCAGCAGATAAGCACATTCCTCACATCCAGGGGAACATGATCAAACTAGAGACCAAGAAGACAAA
ACTCTGATGACTCCCTAGATTCTGTCCTGACCCCAATTCCTGGCCCTGTCTTGAAGCATTTTTTTTCTTCTACTGGATTAGACAAGAGAG
ATAGCAGCATATCAGAGCTGATCTCCTCCACCTTTCTCCAATGACAGAAGTTCCAGGACTGGTTTTCCAGTACATCTTTAAACAAGGCCC
CAGAGACTCTATGTCTGCCCGTCCATCAGTGAACTCATTAAAACTTGTGCAGTGTTGCTGGAGCTGGCCTGGTGTCTCCAAATGACCATG
AAAATACACACGTATAATGGAGATCATTCTCTGTGGGTATGCAAAGTTATGGGAATTCCTTTATAGGTAACTGCCATTTAGGACTGATGG
CCCTAATTTTTGAGGTGCTGATTTAGAGGCAAAATTGCAGAATAACAAAGAAATGGTATTTCAAGTTTTTTTTTTTATAAGCAATGTAAT
TATGCTATTCACAGGGGCCTCAAGAATTGGTATGTATGATGTGATCTGGTCCAGCCAGGGCCTGGCTTGTCAGCTCTCTAGGTTTGATAT
GACTTTAGTAAATTTGTCAATATAGATGGTAGGAAGCAGAATGCCATTTTATTAAAACACAGGAGAAGTTATATCTCTCTGATTATGATA
GTATTTTATTTACTTATCCAAACCCTCCTTTCTCAGTATGGATAGATCATGGAAACCAGATTAGAGATAGTAAGCATTAGTAAACATTGT
TCTGGAGAACAGGAACAGGTGTAAGTTGTAGAAATCCTGAAGAGCCAGTCATTCTTTTACAGAGTACATTCTTCTTAGCCTCTATGGCGC
TGGTCTATGCCCTTCAGTGAACAGTTGTATAAACAATAATTATAATTTGCAACCTTGTCTTGTCAACCTTGCTGATCCAGCTTTTTCTTA
TTATTACACCTTGTCTTGCTTATTGCAGCAAATATTCAATAACAACAATGTTTCTATAAGTCCAACTTCCTTTATTAATGTTTCCATTTA
GCCTCAAAAATATCAAAGTAGTTCCTTTTTGATGTTGTTTTCCTGATTTACTTTTCCCATAAGTTTTAAATACCATTTCTGCCTTGAAGC
CTAGAAATTTTCTTTTTATTCAAAAAAAGTTACATTAATGCTCTAGGTTTGAGGTTCTAAAATGGAAATGTCAATAGAGGAGCATGGTCC
TATGTGAGGTTCCTATCAAAATTTGTGGGAGTAGGGATGGTAGAGCATGAGGGTTTTGTTTGTGTATGTGTATGGTCATGAAAAAAAATT
GAGAAACATTACCTCATACACAATGAATGAATCAGAGGACAGACACGGGAATGGCACGACTGTGCAGTGTGTTACTAGGAAAAAAGTTCA
GAATCACTGTTCTAGAGAGCTTCATTTCCATTGGTTTTAAAACATTATTCTCATGTAGAACAGTGTTGGGTCTCATACTGTTAATGTTAA
TACGTAACAATGTTCATGTTAACAGGCACCTGTTAATATTAACAGATAATGTTACTGTTAACAGGTAAGAGAAATTGCTCTAAGTGCCCA
AACTTTATATACTTCAGTTTTAATGACAAGCATTTCAGAAATATAAGAGCGGCAGCCAGACCAACCAGTTTTTCCAGATATCTTGATGTG
AACCTGACCCTACTCCTTTAGAAGACAGCCTGTTCATTTTTAAATAGCTTTAACCCAAACTGTTCTATGACCATTGTTTCAAGAGACATT
AACACAGTTCTGTAAATAGAAGTGTCTATGGACAAATAAGTTTGGGAAATGTGGCATACTGTATCCTTTTCTTAACATTTGCATATTAAA
GACTCTGAGATATCCTGCAGTAAAGACACAAGATACCTTGTTTAAATTAACATGTACGCTGCAGAACATTGGTTTGGAAAAAACTGTTGA
GCAGTTCTTCCTTGTAAGTGCTGAGCTTCCTCTCTGAAACCTCCTACCATTGTTTTTTTTCCCCTGTAGCTAACAAGAATAAGTATAACA
GCCGGCCAGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGACAGGTGGATCACCTGAGGTCAGGAGTTCGAGACCA
GCCTGGCCAACATGGTGAAACCGTGTCTCTACTAAAAGTACAAAAATTAGCCAGGTGTGATGGCAGGTGCCTGTAATCCCAGCTACTCGG
GAGGCTGAAGCAGAAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAATGAGCCGAGATCACGCCATCACACTCTAGCCTGGGGGACAAG
AGTGAGACTTCATCTAAAAAAAAAAAGAAAAGAATATGTATACCCCCTTTTTCATGTGGCAGATGTTTAGCTATTTGGGGAGAACTTTCA
TGGCTCTTCCCTAATCATCAAGTATTCAAGGTAAAGATTCTCGGTTCCTGTAATGGTTCCTCACCAGGCATAATTTGTCCTTTTACCATC
CTACTTTCTGTCTTCTGAAAAACATTCTTTATCTGAAATACAGCAATTAATATTAAGATATCTTAATATGAAGTGCCTGGAGTCAAATAT
AACATTCCAAAGTAGTCTGACTGGAAGAACTAGCACCTGCCTTTCTTCAAACAATGCACTTCTGTTAATGCAGTGTAAGGTAACATGAGT
TGTTTTTGGAAACTACATCATAATGTGGGCTTACATTCTAGCACTTATCACTTAATGACAGGGATACATTTGAGGAATGCATTGTTAGGC
AATTTTGTCATTATGCAAACATCATAGAGTGTACTTACACAAACCTATGGTATAGCCTACTACACATCTAAGTTATATGGTATAGACTGT
TTCTCCAGCTATATGGTGTAGACTGTTTCTCCTAGGCTACAAACCTGCACAGCATGTTACTGTATTAAATGCTGTAGGCAATTGTAACAC
AATGGTATTTTTATACTTAAACATATCTAAACATAGAAACGGTACAAAAAACTTTACACATTATATAGATGTATCAAATTATTCATATGT
GCTCTGAAAATGTCTATATCTGTTATGTATCAATTTTTTAAAAAGTGAATGACATAATTCATTTGAAAAAATGTGGACACACAAATTGGA

>95964_95964_2_UBB-SLC15A2_UBB_chr17_16285728_ENST00000535788_SLC15A2_chr3_121659775_ENST00000489711_length(amino acids)=156AA_BP=
MPHEKGGIHILFFFFLDEVSLLSPRLECDGVISAHCNLCLPGSSNSSASASRVAGITGTCHHTWLIFVLLVETRFHHVGQAGLELLTSGD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UBB-SLC15A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for UBB-SLC15A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for UBB-SLC15A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource