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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UBB-STARD9 (FusionGDB2 ID:95966)

Fusion Gene Summary for UBB-STARD9

Fusion gene summary

Fusion gene information	Fusion gene name: UBB-STARD9
	Fusion gene ID: 95966
		Hgene	Tgene
	Gene symbol	UBB	STARD9
	Gene ID	7314	57519
	Gene name	ubiquitin B	StAR related lipid transfer domain containing 9
	Synonyms	HEL-S-50	KIF16A
	Cytomap	17p11.2	15q15.2
	Type of gene	protein-coding	protein-coding
	Description	polyubiquitin-Bepididymis secretory protein Li 50polyubiquitin B	stAR-related lipid transfer protein 9START domain-containing protein 9StAR-related lipid transfer (START) domain containing 9
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000535788, ENST00000578649, ENST00000302182, ENST00000395837, ENST00000395839,	ENST00000290607,
Fusion gene scores	* DoF score	7 X 8 X 3=168	6 X 6 X 6=216
	# samples	9	6
	** MAII score	log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/216*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UBB [Title/Abstract] AND STARD9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UBB(16286054)-STARD9(42986726), # samples:1
Anticipated loss of major functional domain due to fusion event.	UBB-STARD9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBB	GO:0031398	positive regulation of protein ubiquitination	24660806
Hgene	UBB	GO:0047497	mitochondrion transport along microtubule	17571083
Hgene	UBB	GO:0051881	regulation of mitochondrial membrane potential	17571083
Hgene	UBB	GO:0061136	regulation of proteasomal protein catabolic process	17571083
Hgene	UBB	GO:1901214	regulation of neuron death	17571083
Hgene	UBB	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	17571083

Fusion gene breakpoints across UBB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STARD9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-JV-A75J-01A	UBB	chr17	16286054	-	STARD9	chr15	42986726	+

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Fusion Gene ORF analysis for UBB-STARD9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000535788	ENST00000290607	UBB	chr17	16286054	-	STARD9	chr15	42986726	+
Frame-shift	ENST00000578649	ENST00000290607	UBB	chr17	16286054	-	STARD9	chr15	42986726	+
In-frame	ENST00000302182	ENST00000290607	UBB	chr17	16286054	-	STARD9	chr15	42986726	+
In-frame	ENST00000395837	ENST00000290607	UBB	chr17	16286054	-	STARD9	chr15	42986726	+
In-frame	ENST00000395839	ENST00000290607	UBB	chr17	16286054	-	STARD9	chr15	42986726	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000302182	UBB	chr17	16286054	-	ENST00000290607	STARD9	chr15	42986726	+	3971	1225	1316	2563	415
ENST00000395839	UBB	chr17	16286054	-	ENST00000290607	STARD9	chr15	42986726	+	3758	1012	1103	2350	415
ENST00000395837	UBB	chr17	16286054	-	ENST00000290607	STARD9	chr15	42986726	+	3760	1014	1105	2352	415

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000302182	ENST00000290607	UBB	chr17	16286054	-	STARD9	chr15	42986726	+	0.08969218	0.9103079
ENST00000395839	ENST00000290607	UBB	chr17	16286054	-	STARD9	chr15	42986726	+	0.089274704	0.9107253
ENST00000395837	ENST00000290607	UBB	chr17	16286054	-	STARD9	chr15	42986726	+	0.08609295	0.913907

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Fusion Genomic Features for UBB-STARD9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBB-STARD9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:16286054/chr15:42986726)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBB

chr17:16286054

chr15:42986726

ENST00000302182

153_228

277

230.0

Domain

Ubiquitin-like 3

Hgene

UBB

chr17:16286054

chr15:42986726

ENST00000302182

1_76

277

230.0

Domain

Ubiquitin-like 1

Hgene

UBB

chr17:16286054

chr15:42986726

ENST00000302182

77_152

277

230.0

Domain

Ubiquitin-like 2

Hgene

UBB

chr17:16286054

chr15:42986726

ENST00000395837

153_228

277

230.0

Domain

Ubiquitin-like 3

Hgene

UBB

chr17:16286054

chr15:42986726

ENST00000395837

1_76

277

230.0

Domain

Ubiquitin-like 1

Hgene

UBB

chr17:16286054

chr15:42986726

ENST00000395837

77_152

277

230.0

Domain

Ubiquitin-like 2

Hgene

UBB

chr17:16286054

chr15:42986726

ENST00000395839

153_228

277

230.0

Domain

Ubiquitin-like 3

Hgene

UBB

chr17:16286054

chr15:42986726

ENST00000395839

1_76

277

230.0

Domain

Ubiquitin-like 1

Hgene

UBB

chr17:16286054

chr15:42986726

ENST00000395839

77_152

277

230.0

Domain

Ubiquitin-like 2

Tgene

STARD9

chr17:16286054

chr15:42986726

ENST00000290607

4334_4387

4254

4701.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

STARD9

chr17:16286054

chr15:42986726

ENST00000290607

4483_4700

4254

4701.0

Domain

START

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

STARD9

chr17:16286054

chr15:42986726

ENST00000290607

1917_1920

4254

4701.0

Compositional bias

Note=Poly-Glu

Tgene

STARD9

chr17:16286054

chr15:42986726

ENST00000290607

2696_2699

4254

4701.0

Compositional bias

Note=Poly-Ser

Tgene

STARD9

chr17:16286054

chr15:42986726

ENST00000290607

649_711

4254

4701.0

Compositional bias

Note=Gln-rich

Tgene

STARD9

chr17:16286054

chr15:42986726

ENST00000290607

3_384

4254

4701.0

Domain

Kinesin motor

Tgene

STARD9

chr17:16286054

chr15:42986726

ENST00000290607

498_569

4254

4701.0

Domain

Note=FHA

Tgene

STARD9

chr17:16286054

chr15:42986726

ENST00000290607

103_110

4254

4701.0

Nucleotide binding

ATP

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Fusion Gene Sequence for UBB-STARD9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>95966_95966_1_UBB-STARD9_UBB_chr17_16286054_ENST00000302182_STARD9_chr15_42986726_ENST00000290607_length(transcript)=3971nt_BP=1225nt
GTTTCCAGAGCTTTCGAGGAAGGTTTCTTCAACTCAAATTCATCCGCCTGATAATTTTCTTATATTTTCCTAAAGAAGGAAGAGAAGCGC
ATAGAGGAGAAGGGAAATAATTTTTTAGGAGCCTTTCTTACGGCTATGAGGAATTTGGGGCTCAGTTGAAAAGCCTAAACTGCCTCTCGG
GAGGTTGGGCGCGGCGAACTACTTTCAGCGGCGCACGGAGACGGCGTCTACGTGAGGGGTGATAAGTGACGCAACACTCGTTGCATAAAT
TTGCGCTCCGCCAGCCCGGAGCATTTAGGGGCGGTTGGCTTTGTTGGGTGAGCTTGTTTGTGTCCCTGTGGGTGGACGTGGTTGGTGATT
GGCAGGATCCTGGTATCCGCTAACAGGTCAAAATGCAGATCTTCGTGAAAACCCTTACCGGCAAGACCATCACCCTTGAGGTGGAGCCCA
GTGACACCATCGAAAATGTGAAGGCCAAGATCCAGGATAAGGAAGGCATTCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGC
TGGAAGATGGCCGTACTCTTTCTGACTACAACATCCAGAAGGAGTCGACCCTGCACCTGGTCCTGCGTCTGAGAGGTGGTATGCAGATCT
TCGTGAAGACCCTGACCGGCAAGACCATCACCCTGGAAGTGGAGCCCAGTGACACCATCGAAAATGTGAAGGCCAAGATCCAGGATAAAG
AAGGCATCCCTCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCTGACTACAACATCCAGAAGG
AGTCGACCCTGCACCTGGTCCTGCGTCTGAGAGGTGGTATGCAGATCTTCGTGAAGACCCTGACCGGCAAGACCATCACTCTGGAGGTGG
AGCCCAGTGACACCATCGAAAATGTGAAGGCCAAGATCCAAGATAAAGAAGGCATCCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCA
AGCAGCTGGAAGATGGCCGCACTCTTTCTGACTACAACATCCAGAAAGAGTCGACCCTGCACCTGGTCCTGCGCCTGAGGGGTGGCTGTT
AATTCTTCAGTCATGGCATTCGCAGTGCCCAGTGATGGCATTACTCTGCACTATAGCCATTTGCCCCAACTTAAGTTTAGAAATTACAAG
TTTCAGTAATAGCTGAACCTGTTCAAAATGTTAATAAAGGTTTCGTTGCATGGTAGCAAAAAAAGGCCATTGAGACCCTCAGGAGAGAGC
GGGCTGAGCGACTTGGGAACTTCTGCCGGACGCGAAGCCTTAGCCCTCAGAAACAACTGAGCCTCCTGCCCAACAAAGATCTCTTCATCT
GGGATCTTGACTTGCCCAGCAGACGCCGAGAATACCTGCAGCAACTGAGGAAGGATGTTGTGGAGACCACCAGGAGCCCAGAGTCAGTGT
CAAGGTCAGCTCACACACCCTCTGACATAGAGTTGATGCTGCAAGACTACCAGCAGGCCCATGAGGAGGCCAAGGTGGAGATTGCCCGGG
CCCGAGACCAACTGCGGGAGCGGACTGAACAAGAGAAGCTGAGAATCCACCAGAAGATCATTTCCCAGCTATTGAAGGAAGAGGATAAAC
TACATACCTTGGCCAATTCCAGCTCCCTGTGCACCAGCTCTAATGGAAGCCTCTCGTCTGGCATGACCTCTGGCTATAATAGCAGCCCAG
CCTTGTCAGGCCAGCTCCAGTTCCCAGAGAATATGGGGCATACAAACTTGCCTGATTCCAGGGATGTATGGATAGGGGATGAGCGAGGAG
GCCATTCTGCAGTGAGGAAGAACTCTGCCTACAGCCACAGAGCCTCCCTGGGCAGTTGCTGCTGTTCACCATCCAGTCTGTCCAGCTTGG
GGACCTGCTTTTCCTCCTCCTACCAGGATTTGGCCAAGCATGTCGTGGACACTTCTATGGCTGATGTAATGGCTGCTTGTTCGGATAATT
TGCACAACCTCTTCAGCTGCCAGGCAACTGCTGGCTGGAACTATCAGGGTGAGGAGCAGGCGGTGCAGCTTTACTACAAGGTGTTTTCTC
CCACTCGGCATGGCTTCCTGGGGGCAGGTGTGGTGTCCCAGCCGCTGTCTCGTGTGTGGGCGGCTGTCAGTGACCCCACTGTGTGGCCCC
TGTATTACAAGCCCATCCAGACAGCAAGGCTGCATCAGCGAGTGACCAACAGCATCAGCCTGGTGTACTTGGTGTGCAACACCACCCTGT
GCGCACTGAAGCAGCCACGGGATTTCTGTTGTGTCTGCGTGGAAGCCAAAGAGGGTCACCTGTCTGTCATGGCAGCCCAGTCTGTGTATG
ATACATCCATGCCAAGACCCAGCAGAAAAATGGTTCGCGGGGAGATCCTGCCCAGTGCCTGGATCTTGCAGCCCATCACTGTGGAAGGGA
AGGAAGTCACCAGAGTCATCTACTTGGCCCAGGTGGAACTTGGTGCTCCAGGCTTCCCACCTCAGCTCCTGAGCTCTTTCATCAAACGGC
AGCCACTGGTTATAGCCAGACTGGCTTCCTTCCTTGGTAGGTAGCATCTCACCGTCAAGATGGTGCTGCTGAGATGCAGGCCCAGGCTGC
TCAAGAGAGACACTGTGGCAGCTCCTTGTTACTTTCCATACCACAGTGCAGGAAAAGCTGATGCTACCTGCTGTGGCCGATTGGGGCAGA
CAGCACTGGCCCAGGGATGCTAGCAAAGCCCAGTCAGTACTTGGTCACAGCTGGCACCAGTGCAGAGCAAACGGCCTGAGCTCCTGGCCC
AGACTATCCAGAGTGAATGCAGCTCCGCTCACCTTTTGGATTTCTCACCTTTCTTTCCTGTTTCTGGGACTCTGCGGCAGACAGGACACT
TAAGGACCAGGACTGGGCACAGCCAGCAGAGCCGGGGACTGCAGTGCTTTGGCAAGGTGCTTCCGCAGGCTGGTAGGGAAGCAGGCAGCC
ACTGGCCAAGACTCTGTTCTGAATCTACCTCCTCTAGCATTCAGCTCTACTGTGTGATGGGACGTTAAAAATACCAAAACAGAAAGAGGG
TTTAAAAAACAGCTGCACAAACCAGAACACCGATTCAGAATCTTTTCTCCCTCTTGAGTTTTTGCAAAATACTTTATTATTGATTTTTGC
TTTTTTTCTCCCTTTCCCTCCCAGGAGAAGACATTTGGGTCTTGGCCTGAGGCAGGGGTGTTGAGCGATGATGCTCTGATATGGAGCTGT
CACTCTAGAGCTCGGTCAGATGGAAGACACTATAGAACCAGGTTGGACAGATTTGGGGTCAGGGTTGGAGGCTGAGTTCTTTTGAGGACT
GGTTGGAGTGGCAGCCAGATGGTGGCTGCTGACAAGGCAAGAGGAATTTCAGAGATTAAACATTGTCCTTTGAGGAAGGGAGAGGAGGTG
AATGAACTCCCAGAGGAGGTGAGTGGCTTGTTGGGAGGAAGCTCAGTTCCAGAACTTACCTCAGTGCACTTGGGAGGGGTGGAGTCCTGA
GCATTCCATGATTTCTGCCCTGGCCCCACCTATCCTAGGATGGGGTGGGATGGAGAGTGGGTTCAGTTTTCTTGTACTTTAGCCTGGCTG
AACATGAACTTTGTGTTTACCTGGAAGTGGTAGGGGTGGGAGAGATTCTCATCTTTAGTTCTGGTGCCCAAAATCTTTGGTAGATGGAGG
GAACTGGGGATTCAGAAGATGTGGTAAAGGTCTATTTCTGTAGTGTGGCAGAGATGTGTTTTTCTAAAGTGTTTGCAGGGCATTTTTCCC
TCTTACCTCAGATTAAGTTATTTATATATTGTTGATTGAAGGTTTTTTAAAATTGCTTTTAAACTTCTATTTCTCGGGTAAATTTTTTGG
TGACATGATATATTTAACACCCTATTTATATACTCCTACCTCTTTTCATATAAATCTCTTACTAAGACTACTGACCAAAAAAGAACATTT

>95966_95966_1_UBB-STARD9_UBB_chr17_16286054_ENST00000302182_STARD9_chr15_42986726_ENST00000290607_length(amino acids)=415AA_BP=
MSLLPNKDLFIWDLDLPSRRREYLQQLRKDVVETTRSPESVSRSAHTPSDIELMLQDYQQAHEEAKVEIARARDQLRERTEQEKLRIHQK
IISQLLKEEDKLHTLANSSSLCTSSNGSLSSGMTSGYNSSPALSGQLQFPENMGHTNLPDSRDVWIGDERGGHSAVRKNSAYSHRASLGS
CCCSPSSLSSLGTCFSSSYQDLAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAVQLYYKVFSPTRHGFLGAGVVSQPLSRV
WAAVSDPTVWPLYYKPIQTARLHQRVTNSISLVYLVCNTTLCALKQPRDFCCVCVEAKEGHLSVMAAQSVYDTSMPRPSRKMVRGEILPS

--------------------------------------------------------------
>95966_95966_2_UBB-STARD9_UBB_chr17_16286054_ENST00000395837_STARD9_chr15_42986726_ENST00000290607_length(transcript)=3760nt_BP=1014nt
GGGCCTTGTTGACCTGAGGGGGGCGAGGGCGGTTGGCGCGCGCGCGCGTTGACGGAAACTAACGGACGCCTAACCGATCGGCGATTCTGT
CGAGTTTACTTCGCGGGGAAGGCGGAAAAGAGGTAGTTTGTGTGGTTTCTGGAAGCCTTTACTTTGGAATCCCAGTGTGAGAAAGGTCAA
AATGCAGATCTTCGTGAAAACCCTTACCGGCAAGACCATCACCCTTGAGGTGGAGCCCAGTGACACCATCGAAAATGTGAAGGCCAAGAT
CCAGGATAAGGAAGGCATTCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGTACTCTTTCTGACTACAA
CATCCAGAAGGAGTCGACCCTGCACCTGGTCCTGCGTCTGAGAGGTGGTATGCAGATCTTCGTGAAGACCCTGACCGGCAAGACCATCAC
CCTGGAAGTGGAGCCCAGTGACACCATCGAAAATGTGAAGGCCAAGATCCAGGATAAAGAAGGCATCCCTCCCGACCAGCAGAGGCTCAT
CTTTGCAGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCTGACTACAACATCCAGAAGGAGTCGACCCTGCACCTGGTCCTGCGTCTGAG
AGGTGGTATGCAGATCTTCGTGAAGACCCTGACCGGCAAGACCATCACTCTGGAGGTGGAGCCCAGTGACACCATCGAAAATGTGAAGGC
CAAGATCCAAGATAAAGAAGGCATCCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCTGA
CTACAACATCCAGAAAGAGTCGACCCTGCACCTGGTCCTGCGCCTGAGGGGTGGCTGTTAATTCTTCAGTCATGGCATTCGCAGTGCCCA
GTGATGGCATTACTCTGCACTATAGCCATTTGCCCCAACTTAAGTTTAGAAATTACAAGTTTCAGTAATAGCTGAACCTGTTCAAAATGT
TAATAAAGGTTTCGTTGCATGGTAGCAAAAAAAGGCCATTGAGACCCTCAGGAGAGAGCGGGCTGAGCGACTTGGGAACTTCTGCCGGAC
GCGAAGCCTTAGCCCTCAGAAACAACTGAGCCTCCTGCCCAACAAAGATCTCTTCATCTGGGATCTTGACTTGCCCAGCAGACGCCGAGA
ATACCTGCAGCAACTGAGGAAGGATGTTGTGGAGACCACCAGGAGCCCAGAGTCAGTGTCAAGGTCAGCTCACACACCCTCTGACATAGA
GTTGATGCTGCAAGACTACCAGCAGGCCCATGAGGAGGCCAAGGTGGAGATTGCCCGGGCCCGAGACCAACTGCGGGAGCGGACTGAACA
AGAGAAGCTGAGAATCCACCAGAAGATCATTTCCCAGCTATTGAAGGAAGAGGATAAACTACATACCTTGGCCAATTCCAGCTCCCTGTG
CACCAGCTCTAATGGAAGCCTCTCGTCTGGCATGACCTCTGGCTATAATAGCAGCCCAGCCTTGTCAGGCCAGCTCCAGTTCCCAGAGAA
TATGGGGCATACAAACTTGCCTGATTCCAGGGATGTATGGATAGGGGATGAGCGAGGAGGCCATTCTGCAGTGAGGAAGAACTCTGCCTA
CAGCCACAGAGCCTCCCTGGGCAGTTGCTGCTGTTCACCATCCAGTCTGTCCAGCTTGGGGACCTGCTTTTCCTCCTCCTACCAGGATTT
GGCCAAGCATGTCGTGGACACTTCTATGGCTGATGTAATGGCTGCTTGTTCGGATAATTTGCACAACCTCTTCAGCTGCCAGGCAACTGC
TGGCTGGAACTATCAGGGTGAGGAGCAGGCGGTGCAGCTTTACTACAAGGTGTTTTCTCCCACTCGGCATGGCTTCCTGGGGGCAGGTGT
GGTGTCCCAGCCGCTGTCTCGTGTGTGGGCGGCTGTCAGTGACCCCACTGTGTGGCCCCTGTATTACAAGCCCATCCAGACAGCAAGGCT
GCATCAGCGAGTGACCAACAGCATCAGCCTGGTGTACTTGGTGTGCAACACCACCCTGTGCGCACTGAAGCAGCCACGGGATTTCTGTTG
TGTCTGCGTGGAAGCCAAAGAGGGTCACCTGTCTGTCATGGCAGCCCAGTCTGTGTATGATACATCCATGCCAAGACCCAGCAGAAAAAT
GGTTCGCGGGGAGATCCTGCCCAGTGCCTGGATCTTGCAGCCCATCACTGTGGAAGGGAAGGAAGTCACCAGAGTCATCTACTTGGCCCA
GGTGGAACTTGGTGCTCCAGGCTTCCCACCTCAGCTCCTGAGCTCTTTCATCAAACGGCAGCCACTGGTTATAGCCAGACTGGCTTCCTT
CCTTGGTAGGTAGCATCTCACCGTCAAGATGGTGCTGCTGAGATGCAGGCCCAGGCTGCTCAAGAGAGACACTGTGGCAGCTCCTTGTTA
CTTTCCATACCACAGTGCAGGAAAAGCTGATGCTACCTGCTGTGGCCGATTGGGGCAGACAGCACTGGCCCAGGGATGCTAGCAAAGCCC
AGTCAGTACTTGGTCACAGCTGGCACCAGTGCAGAGCAAACGGCCTGAGCTCCTGGCCCAGACTATCCAGAGTGAATGCAGCTCCGCTCA
CCTTTTGGATTTCTCACCTTTCTTTCCTGTTTCTGGGACTCTGCGGCAGACAGGACACTTAAGGACCAGGACTGGGCACAGCCAGCAGAG
CCGGGGACTGCAGTGCTTTGGCAAGGTGCTTCCGCAGGCTGGTAGGGAAGCAGGCAGCCACTGGCCAAGACTCTGTTCTGAATCTACCTC
CTCTAGCATTCAGCTCTACTGTGTGATGGGACGTTAAAAATACCAAAACAGAAAGAGGGTTTAAAAAACAGCTGCACAAACCAGAACACC
GATTCAGAATCTTTTCTCCCTCTTGAGTTTTTGCAAAATACTTTATTATTGATTTTTGCTTTTTTTCTCCCTTTCCCTCCCAGGAGAAGA
CATTTGGGTCTTGGCCTGAGGCAGGGGTGTTGAGCGATGATGCTCTGATATGGAGCTGTCACTCTAGAGCTCGGTCAGATGGAAGACACT
ATAGAACCAGGTTGGACAGATTTGGGGTCAGGGTTGGAGGCTGAGTTCTTTTGAGGACTGGTTGGAGTGGCAGCCAGATGGTGGCTGCTG
ACAAGGCAAGAGGAATTTCAGAGATTAAACATTGTCCTTTGAGGAAGGGAGAGGAGGTGAATGAACTCCCAGAGGAGGTGAGTGGCTTGT
TGGGAGGAAGCTCAGTTCCAGAACTTACCTCAGTGCACTTGGGAGGGGTGGAGTCCTGAGCATTCCATGATTTCTGCCCTGGCCCCACCT
ATCCTAGGATGGGGTGGGATGGAGAGTGGGTTCAGTTTTCTTGTACTTTAGCCTGGCTGAACATGAACTTTGTGTTTACCTGGAAGTGGT
AGGGGTGGGAGAGATTCTCATCTTTAGTTCTGGTGCCCAAAATCTTTGGTAGATGGAGGGAACTGGGGATTCAGAAGATGTGGTAAAGGT
CTATTTCTGTAGTGTGGCAGAGATGTGTTTTTCTAAAGTGTTTGCAGGGCATTTTTCCCTCTTACCTCAGATTAAGTTATTTATATATTG
TTGATTGAAGGTTTTTTAAAATTGCTTTTAAACTTCTATTTCTCGGGTAAATTTTTTGGTGACATGATATATTTAACACCCTATTTATAT

>95966_95966_2_UBB-STARD9_UBB_chr17_16286054_ENST00000395837_STARD9_chr15_42986726_ENST00000290607_length(amino acids)=415AA_BP=
MSLLPNKDLFIWDLDLPSRRREYLQQLRKDVVETTRSPESVSRSAHTPSDIELMLQDYQQAHEEAKVEIARARDQLRERTEQEKLRIHQK
IISQLLKEEDKLHTLANSSSLCTSSNGSLSSGMTSGYNSSPALSGQLQFPENMGHTNLPDSRDVWIGDERGGHSAVRKNSAYSHRASLGS
CCCSPSSLSSLGTCFSSSYQDLAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAVQLYYKVFSPTRHGFLGAGVVSQPLSRV
WAAVSDPTVWPLYYKPIQTARLHQRVTNSISLVYLVCNTTLCALKQPRDFCCVCVEAKEGHLSVMAAQSVYDTSMPRPSRKMVRGEILPS

--------------------------------------------------------------
>95966_95966_3_UBB-STARD9_UBB_chr17_16286054_ENST00000395839_STARD9_chr15_42986726_ENST00000290607_length(transcript)=3758nt_BP=1012nt
GTGGGGGAGGGGAGGGCGAGGTGACGCGGCGCTGGGCCTTTCCGGGACAGTGGGCCTTGTTGACCTGAGGGGGGCGAGGGCGGTTGGCGC
GCGCGCGCGTTGACGGAAACTAACGGACGCCTAACCGATCGGCGATTCTGTCGAGTTTACTTCGCGGGGAAGGCGGAAAAGAGGTCAAAA
TGCAGATCTTCGTGAAAACCCTTACCGGCAAGACCATCACCCTTGAGGTGGAGCCCAGTGACACCATCGAAAATGTGAAGGCCAAGATCC
AGGATAAGGAAGGCATTCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGTACTCTTTCTGACTACAACA
TCCAGAAGGAGTCGACCCTGCACCTGGTCCTGCGTCTGAGAGGTGGTATGCAGATCTTCGTGAAGACCCTGACCGGCAAGACCATCACCC
TGGAAGTGGAGCCCAGTGACACCATCGAAAATGTGAAGGCCAAGATCCAGGATAAAGAAGGCATCCCTCCCGACCAGCAGAGGCTCATCT
TTGCAGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCTGACTACAACATCCAGAAGGAGTCGACCCTGCACCTGGTCCTGCGTCTGAGAG
GTGGTATGCAGATCTTCGTGAAGACCCTGACCGGCAAGACCATCACTCTGGAGGTGGAGCCCAGTGACACCATCGAAAATGTGAAGGCCA
AGATCCAAGATAAAGAAGGCATCCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCTGACT
ACAACATCCAGAAAGAGTCGACCCTGCACCTGGTCCTGCGCCTGAGGGGTGGCTGTTAATTCTTCAGTCATGGCATTCGCAGTGCCCAGT
GATGGCATTACTCTGCACTATAGCCATTTGCCCCAACTTAAGTTTAGAAATTACAAGTTTCAGTAATAGCTGAACCTGTTCAAAATGTTA
ATAAAGGTTTCGTTGCATGGTAGCAAAAAAAGGCCATTGAGACCCTCAGGAGAGAGCGGGCTGAGCGACTTGGGAACTTCTGCCGGACGC
GAAGCCTTAGCCCTCAGAAACAACTGAGCCTCCTGCCCAACAAAGATCTCTTCATCTGGGATCTTGACTTGCCCAGCAGACGCCGAGAAT
ACCTGCAGCAACTGAGGAAGGATGTTGTGGAGACCACCAGGAGCCCAGAGTCAGTGTCAAGGTCAGCTCACACACCCTCTGACATAGAGT
TGATGCTGCAAGACTACCAGCAGGCCCATGAGGAGGCCAAGGTGGAGATTGCCCGGGCCCGAGACCAACTGCGGGAGCGGACTGAACAAG
AGAAGCTGAGAATCCACCAGAAGATCATTTCCCAGCTATTGAAGGAAGAGGATAAACTACATACCTTGGCCAATTCCAGCTCCCTGTGCA
CCAGCTCTAATGGAAGCCTCTCGTCTGGCATGACCTCTGGCTATAATAGCAGCCCAGCCTTGTCAGGCCAGCTCCAGTTCCCAGAGAATA
TGGGGCATACAAACTTGCCTGATTCCAGGGATGTATGGATAGGGGATGAGCGAGGAGGCCATTCTGCAGTGAGGAAGAACTCTGCCTACA
GCCACAGAGCCTCCCTGGGCAGTTGCTGCTGTTCACCATCCAGTCTGTCCAGCTTGGGGACCTGCTTTTCCTCCTCCTACCAGGATTTGG
CCAAGCATGTCGTGGACACTTCTATGGCTGATGTAATGGCTGCTTGTTCGGATAATTTGCACAACCTCTTCAGCTGCCAGGCAACTGCTG
GCTGGAACTATCAGGGTGAGGAGCAGGCGGTGCAGCTTTACTACAAGGTGTTTTCTCCCACTCGGCATGGCTTCCTGGGGGCAGGTGTGG
TGTCCCAGCCGCTGTCTCGTGTGTGGGCGGCTGTCAGTGACCCCACTGTGTGGCCCCTGTATTACAAGCCCATCCAGACAGCAAGGCTGC
ATCAGCGAGTGACCAACAGCATCAGCCTGGTGTACTTGGTGTGCAACACCACCCTGTGCGCACTGAAGCAGCCACGGGATTTCTGTTGTG
TCTGCGTGGAAGCCAAAGAGGGTCACCTGTCTGTCATGGCAGCCCAGTCTGTGTATGATACATCCATGCCAAGACCCAGCAGAAAAATGG
TTCGCGGGGAGATCCTGCCCAGTGCCTGGATCTTGCAGCCCATCACTGTGGAAGGGAAGGAAGTCACCAGAGTCATCTACTTGGCCCAGG
TGGAACTTGGTGCTCCAGGCTTCCCACCTCAGCTCCTGAGCTCTTTCATCAAACGGCAGCCACTGGTTATAGCCAGACTGGCTTCCTTCC
TTGGTAGGTAGCATCTCACCGTCAAGATGGTGCTGCTGAGATGCAGGCCCAGGCTGCTCAAGAGAGACACTGTGGCAGCTCCTTGTTACT
TTCCATACCACAGTGCAGGAAAAGCTGATGCTACCTGCTGTGGCCGATTGGGGCAGACAGCACTGGCCCAGGGATGCTAGCAAAGCCCAG
TCAGTACTTGGTCACAGCTGGCACCAGTGCAGAGCAAACGGCCTGAGCTCCTGGCCCAGACTATCCAGAGTGAATGCAGCTCCGCTCACC
TTTTGGATTTCTCACCTTTCTTTCCTGTTTCTGGGACTCTGCGGCAGACAGGACACTTAAGGACCAGGACTGGGCACAGCCAGCAGAGCC
GGGGACTGCAGTGCTTTGGCAAGGTGCTTCCGCAGGCTGGTAGGGAAGCAGGCAGCCACTGGCCAAGACTCTGTTCTGAATCTACCTCCT
CTAGCATTCAGCTCTACTGTGTGATGGGACGTTAAAAATACCAAAACAGAAAGAGGGTTTAAAAAACAGCTGCACAAACCAGAACACCGA
TTCAGAATCTTTTCTCCCTCTTGAGTTTTTGCAAAATACTTTATTATTGATTTTTGCTTTTTTTCTCCCTTTCCCTCCCAGGAGAAGACA
TTTGGGTCTTGGCCTGAGGCAGGGGTGTTGAGCGATGATGCTCTGATATGGAGCTGTCACTCTAGAGCTCGGTCAGATGGAAGACACTAT
AGAACCAGGTTGGACAGATTTGGGGTCAGGGTTGGAGGCTGAGTTCTTTTGAGGACTGGTTGGAGTGGCAGCCAGATGGTGGCTGCTGAC
AAGGCAAGAGGAATTTCAGAGATTAAACATTGTCCTTTGAGGAAGGGAGAGGAGGTGAATGAACTCCCAGAGGAGGTGAGTGGCTTGTTG
GGAGGAAGCTCAGTTCCAGAACTTACCTCAGTGCACTTGGGAGGGGTGGAGTCCTGAGCATTCCATGATTTCTGCCCTGGCCCCACCTAT
CCTAGGATGGGGTGGGATGGAGAGTGGGTTCAGTTTTCTTGTACTTTAGCCTGGCTGAACATGAACTTTGTGTTTACCTGGAAGTGGTAG
GGGTGGGAGAGATTCTCATCTTTAGTTCTGGTGCCCAAAATCTTTGGTAGATGGAGGGAACTGGGGATTCAGAAGATGTGGTAAAGGTCT
ATTTCTGTAGTGTGGCAGAGATGTGTTTTTCTAAAGTGTTTGCAGGGCATTTTTCCCTCTTACCTCAGATTAAGTTATTTATATATTGTT
GATTGAAGGTTTTTTAAAATTGCTTTTAAACTTCTATTTCTCGGGTAAATTTTTTGGTGACATGATATATTTAACACCCTATTTATATAC

>95966_95966_3_UBB-STARD9_UBB_chr17_16286054_ENST00000395839_STARD9_chr15_42986726_ENST00000290607_length(amino acids)=415AA_BP=
MSLLPNKDLFIWDLDLPSRRREYLQQLRKDVVETTRSPESVSRSAHTPSDIELMLQDYQQAHEEAKVEIARARDQLRERTEQEKLRIHQK
IISQLLKEEDKLHTLANSSSLCTSSNGSLSSGMTSGYNSSPALSGQLQFPENMGHTNLPDSRDVWIGDERGGHSAVRKNSAYSHRASLGS
CCCSPSSLSSLGTCFSSSYQDLAKHVVDTSMADVMAACSDNLHNLFSCQATAGWNYQGEEQAVQLYYKVFSPTRHGFLGAGVVSQPLSRV
WAAVSDPTVWPLYYKPIQTARLHQRVTNSISLVYLVCNTTLCALKQPRDFCCVCVEAKEGHLSVMAAQSVYDTSMPRPSRKMVRGEILPS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UBB-STARD9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for UBB-STARD9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for UBB-STARD9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source