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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UBE2C-CDH26 (FusionGDB2 ID:95994)

Fusion Gene Summary for UBE2C-CDH26

Fusion gene summary

Fusion gene information	Fusion gene name: UBE2C-CDH26
	Fusion gene ID: 95994
		Hgene	Tgene
	Gene symbol	UBE2C	CDH26
	Gene ID	11065	60437
	Gene name	ubiquitin conjugating enzyme E2 C	cadherin 26
	Synonyms	UBCH10\|dJ447F3.2	VR20
	Cytomap	20q13.12	20q13.33
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin-conjugating enzyme E2 C(E3-independent) E2 ubiquitin-conjugating enzyme CE2 ubiquitin-conjugating enzyme Ccyclin-selective ubiquitin carrier proteinmitotic-specific ubiquitin-conjugating enzymeubiquitin conjugating enzyme E2Cubiquitin-prot	cadherin-like protein 26cadherin-like 26cadherin-like protein VR20
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000496085, ENST00000335046, ENST00000356455, ENST00000372568, ENST00000405520, ENST00000243893, ENST00000352551,	ENST00000244047, ENST00000244049, ENST00000348616, ENST00000350849, ENST00000497614,
Fusion gene scores	* DoF score	8 X 6 X 3=144	3 X 4 X 2=24
	# samples	8	3
	** MAII score	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/24*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: UBE2C [Title/Abstract] AND CDH26 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UBE2C(44443109)-CDH26(58544022), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBE2C	GO:0006511	ubiquitin-dependent protein catabolic process	9122200\|18485873
Hgene	UBE2C	GO:0010994	free ubiquitin chain polymerization	19822757
Hgene	UBE2C	GO:0016567	protein ubiquitination	9122200
Hgene	UBE2C	GO:0031145	anaphase-promoting complex-dependent catabolic process	9122200\|19822757
Hgene	UBE2C	GO:0070936	protein K48-linked ubiquitination	20061386
Hgene	UBE2C	GO:0070979	protein K11-linked ubiquitination	18485873\|19822757\|20061386
Tgene	CDH26	GO:0035710	CD4-positive, alpha-beta T cell activation	28051089

Fusion gene breakpoints across UBE2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDH26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AN-A0FY-01A	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+

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Fusion Gene ORF analysis for UBE2C-CDH26

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000496085	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
3UTR-intron	ENST00000496085	ENST00000244049	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
3UTR-intron	ENST00000496085	ENST00000348616	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
3UTR-intron	ENST00000496085	ENST00000350849	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
3UTR-intron	ENST00000496085	ENST00000497614	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000335046	ENST00000244049	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000335046	ENST00000348616	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000335046	ENST00000350849	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000335046	ENST00000497614	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000356455	ENST00000244049	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000356455	ENST00000348616	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000356455	ENST00000350849	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000356455	ENST00000497614	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000372568	ENST00000244049	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000372568	ENST00000348616	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000372568	ENST00000350849	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000372568	ENST00000497614	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000405520	ENST00000244049	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000405520	ENST00000348616	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000405520	ENST00000350849	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
5CDS-intron	ENST00000405520	ENST00000497614	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
In-frame	ENST00000335046	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
In-frame	ENST00000356455	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
In-frame	ENST00000372568	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
In-frame	ENST00000405520	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
intron-3CDS	ENST00000243893	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
intron-3CDS	ENST00000352551	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
intron-intron	ENST00000243893	ENST00000244049	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
intron-intron	ENST00000243893	ENST00000348616	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
intron-intron	ENST00000243893	ENST00000350849	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
intron-intron	ENST00000243893	ENST00000497614	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
intron-intron	ENST00000352551	ENST00000244049	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
intron-intron	ENST00000352551	ENST00000348616	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
intron-intron	ENST00000352551	ENST00000350849	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+
intron-intron	ENST00000352551	ENST00000497614	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000356455

UBE2C

chr20

44443109

ENST00000244047

CDH26

chr20

58544022

2826

336

2825

939

ENST00000405520

UBE2C

chr20

44443109

ENST00000244047

CDH26

chr20

58544022

3426

936

834

3425

863

ENST00000335046

UBE2C

chr20

44443109

ENST00000244047

CDH26

chr20

58544022

2767

277

2766

920

ENST00000372568

UBE2C

chr20

44443109

ENST00000244047

CDH26

chr20

58544022

2890

400

274

2889

872

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356455	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+	0.001067794	0.9989322
ENST00000405520	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+	0.001372358	0.99862766
ENST00000335046	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+	0.001178167	0.9988218
ENST00000372568	ENST00000244047	UBE2C	chr20	44443109	+	CDH26	chr20	58544022	+	0.001157907	0.9988422

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Fusion Genomic Features for UBE2C-CDH26

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
UBE2C	chr20	44443109	+	CDH26	chr20	58544021	+	0.04116962	0.9588304
UBE2C	chr20	44443109	+	CDH26	chr20	58544021	+	0.04116962	0.9588304

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBE2C-CDH26

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:44443109/chr20:58544022)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244047

166_275

853.0

Domain

Cadherin 2

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244047

276_396

853.0

Domain

Cadherin 3

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244047

35_165

853.0

Domain

Cadherin 1

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244047

397_500

853.0

Domain

Cadherin 4

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244049

166_275

125.0

Domain

Cadherin 2

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244049

276_396

125.0

Domain

Cadherin 3

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244049

35_165

125.0

Domain

Cadherin 1

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244049

397_500

125.0

Domain

Cadherin 4

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000348616

166_275

833.0

Domain

Cadherin 2

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000348616

276_396

833.0

Domain

Cadherin 3

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000348616

35_165

833.0

Domain

Cadherin 1

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000348616

397_500

833.0

Domain

Cadherin 4

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000350849

166_275

166.0

Domain

Cadherin 2

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000350849

276_396

166.0

Domain

Cadherin 3

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000350849

35_165

166.0

Domain

Cadherin 1

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000350849

397_500

166.0

Domain

Cadherin 4

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244047

28_614

853.0

Topological domain

Extracellular

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244047

636_832

853.0

Topological domain

Cytoplasmic

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244049

28_614

125.0

Topological domain

Extracellular

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244049

636_832

125.0

Topological domain

Cytoplasmic

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000348616

28_614

833.0

Topological domain

Extracellular

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000348616

636_832

833.0

Topological domain

Cytoplasmic

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000350849

28_614

166.0

Topological domain

Extracellular

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000350849

636_832

166.0

Topological domain

Cytoplasmic

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244047

615_635

853.0

Transmembrane

Helical

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000244049

615_635

125.0

Transmembrane

Helical

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000348616

615_635

833.0

Transmembrane

Helical

Tgene

CDH26

chr20:44443109

chr20:58544022

ENST00000350849

615_635

166.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBE2C

chr20:44443109

chr20:58544022

ENST00000335046

30_175

162.0

Domain

UBC core

Hgene

UBE2C

chr20:44443109

chr20:58544022

ENST00000352551

30_175

151.0

Domain

UBC core

Hgene

UBE2C

chr20:44443109

chr20:58544022

ENST00000356455

30_175

180.0

Domain

UBC core

Hgene

UBE2C

chr20:44443109

chr20:58544022

ENST00000372568

30_175

141.0

Domain

UBC core

Hgene

UBE2C

chr20:44443109

chr20:58544022

ENST00000405520

30_175

141.0

Domain

UBC core

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Fusion Gene Sequence for UBE2C-CDH26

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>95994_95994_1_UBE2C-CDH26_UBE2C_chr20_44443109_ENST00000335046_CDH26_chr20_58544022_ENST00000244047_length(transcript)=2767nt_BP=277nt
CGCAGTCCTGCAGTTGCAGTCGTGTTCTCCGAGTTCCTGTCTCTCTGCCAACGCCGCCCGGATGGCTTCCCAAAACCGCGACCCAGCCGC
CACTAGCGTCGCCGCCGCCCGTAAAGGAGCTGAGCCGAGCGGGGGCGCCGCCCGGGGTCCGGTGGGCAAAAGGCTACAGCAGGAGCTGAT
GACCCTCATGATGTCTGGCGATAAAGGGATTTCTGCCTTCCCTGAATCAGACAACCTTTTCAAATGGGTAGGGACCATCCATGGAGCAGC
TGGAACAGTCAGTATCATTGACAGTGTTCAACAGGAAACAGATGATCTTACTAAGCAAACAAAGGAAAAGATCTACCAGCCTCTACGGCG
ATCCAAGAGAAGATGGGTTATCACCACCTTGGAGCTGGAGGAGGAAGACCCGGGACCCTTTCCCAAACTCATTGGTGAGCTGTTCAATAA
TATGTCTTATAACATGTCACTAATGTATCTAATCAGTGGACCTGGTGTGGATGAATATCCAGAGATTGGTTTGTTTTCTCTAGAAGATCA
TGAGAACGGAAGGATATATGTTCACCGCCCTGTCGATCGAGAAATGACACCATCTTTCACGGTTTATTTTGATGTTGTGGAGCGCTCAAC
AGGAAAAATTGTGGATACATCCTTGATTTTCAACATTAGGATCAGTGATGTGAATGATCATGCACCCCAGTTTCCAGAGAAGGAATTTAA
CATCACTGTGCAAGAAAACCAATCTGCAGGGCAACCTATTTTTCAGATGTTAGCAGTCGATTTGGATGAAGAAAACACTCCAAATTCTCA
AGTCCTTTACTTCCTCATTTCTCAAACACCATTACTGAAAGAAAGTGGTTTCCGGGTTGATCGCCTTAGTGGAGAAATACGACTCTCTGG
CTGCTTAGATTATGAGACCGCTCCTCAGTTTACACTGCTAATCAGAGCCAGGGACTGTGGAGAACCGTCACTGTCATCCACGACCACCGT
TCACGTGGATGTGCAAGAAGGCAACAACCACAGGCCTGCATTTACCCAGGAGAACTATAAGGTTCAGATTCCTGAAGGCCGAGCCAGCCA
GGGCGTGTTGCGTCTCCTGGTTCAAGATCGAGATTCTCCATTTACATCAGCTTGGAGAGCAAAATTCAACATATTGCATGGCAATGAAGA
GGGGCATTTTGACATTTCGACTGACCCTGAGACCAACGAAGGGATATTAAATGTTATCAAGCCTTTGGATTATGAGACTCGCCCAGCGCA
AAGCCTCATCATTGTCGTGGAGAATGAGGAGAGGCTCGTCTTCTGTGAGAGAGGAAAGCTTCAGCCGCCAAGGAAGGCAGCAGCCAGCGC
CACTGTGAGTGTGCAGGTGACAGACGCCAACGACCCACCAGCCTTTCACCCCCAGAGCTTCATTGTCAATAAAGAGGAGGGCGCCAGGCC
TGGGACCCTGTTGGGAACTTTTAATGCCATGGATCCAGACAGCCAGATAAGATATGAACTGGTTCATGACCCAGCAAATTGGGTCAGCGT
CGACAAAAACTCCGGAGTGGTCATCACCGTGGAGCCAATTGACCGAGAATCCCCTCATGTAAATAACAGTTTTTATGTAATCATCATTCA
CGCTGTTGATGATGGCTTCCCACCGCAGACTGCTACAGGGACCCTAATGCTCTTCCTGTCTGACATCAATGACAACGTCCCGACTCTCCG
GCCACGTTCCCGCTACATGGAGGTCTGTGAGTCTGCTGTGCATGAGCCCCTCCACATCGAGGCAGAGGATCCGGACCTGGAGCCGTTCTC
TGACCCATTTACATTTGAATTGGACAATACCTGGGGAAATGCGGAGGACACATGGAAGTTGGGGAGAAATTGGGGTCAATCAGTTGAACT
TTTAACCTTGAGAAGCCTGCCACGTGGTAATTACTTGGTGCCACTCTTCATTGGAGACAAACAGGGACTTTCCCAGAAGCAAACTGTCCA
TGTAAGGATCTGCCCCTGTGCCAGTGGGCTCACATGTGTGGAGCTTGCAGATGCAGAAGTGGGGCTTCATGTGGGGGCCCTGTTCCCTGT
CTGTGCAGCATTTGTGGCTCTGGCAGTGGCTCTGCTTTTTCTGTTGCGATGCTATTTTGTGCTTGAACCTAAGAGGCATGGATGCTCTGT
ATCCAATGATGAAGGCCACCAAACACTGGTCATGTATAATGCGGAGAGCAAAGGCACTTCAGCCCAGACATGGTCAGATGTTGAAGGCCA
GAGGCCGGCTCTGCTCATCTGCACAGCTGCAGCAGGACCCACGCAGGGAGTTAAGGCTTACCCAGATGCCACAATGCACAGACAACTCCT
GGCTCCGGTGGAAGGAAGGATGGCAGAGACATTGAATCAGTCTAAAGAGAGAAATCGCTTCAGCCTCAGCAGGGGCTGCATCATCCCCCA
GGGAAGAGCCACAGCTGGGCGAGGATTGCCACAAGACATTTACAAGGAGATGATGCCACGGAGACTAACGCAGACTGGTAAACGGAAACA
CGGGGCTTTGGCTCGAACACCCTCTTTCAAGAAAGTTGTTTATGACCACAAGGAAGATGAGGAGAACAAGGCTGGGAGAAAGCAAAGGAG
CCACTTGTTTAAGGTTATGCAGCTGAGAAATGAACAAGGTGGGGTTCGAGTCCAGAGTGCGCATTCCCCATCACCCCTTAACAAAAAGGC

>95994_95994_1_UBE2C-CDH26_UBE2C_chr20_44443109_ENST00000335046_CDH26_chr20_58544022_ENST00000244047_length(amino acids)=920AA_BP=90
MQLQSCSPSSCLSANAARMASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGT
VSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPFPKLIGELFNNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHEN
GRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVL
YFLISQTPLLKESGFRVDRLSGEIRLSGCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGV
LRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATV
SVQVTDANDPPAFHPQSFIVNKEEGARPGTLLGTFNAMDPDSQIRYELVHDPANWVSVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAV
DDGFPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDLEPFSDPFTFELDNTWGNAEDTWKLGRNWGQSVELLT
LRSLPRGNYLVPLFIGDKQGLSQKQTVHVRICPCASGLTCVELADAEVGLHVGALFPVCAAFVALAVALLFLLRCYFVLEPKRHGCSVSN
DEGHQTLVMYNAESKGTSAQTWSDVEGQRPALLICTAAAGPTQGVKAYPDATMHRQLLAPVEGRMAETLNQSKERNRFSLSRGCIIPQGR
ATAGRGLPQDIYKEMMPRRLTQTGKRKHGALARTPSFKKVVYDHKEDEENKAGRKQRSHLFKVMQLRNEQGGVRVQSAHSPSPLNKKACF

--------------------------------------------------------------
>95994_95994_2_UBE2C-CDH26_UBE2C_chr20_44443109_ENST00000356455_CDH26_chr20_58544022_ENST00000244047_length(transcript)=2826nt_BP=336nt
GAGCCATTGATTGGTCGACGCCCCCAGAGGGTTACAATTCAAACGCGGGCGGGCGGGCCCGCAGTCCTGCAGTTGCAGTCGTGTTCTCCG
AGTTCCTGTCTCTCTGCCAACGCCGCCCGGATGGCTTCCCAAAACCGCGACCCAGCCGCCACTAGCGTCGCCGCCGCCCGTAAAGGAGCT
GAGCCGAGCGGGGGCGCCGCCCGGGGTCCGGTGGGCAAAAGGCTACAGCAGGAGCTGATGACCCTCATGATGTCTGGCGATAAAGGGATT
TCTGCCTTCCCTGAATCAGACAACCTTTTCAAATGGGTAGGGACCATCCATGGAGCAGCTGGAACAGTCAGTATCATTGACAGTGTTCAA
CAGGAAACAGATGATCTTACTAAGCAAACAAAGGAAAAGATCTACCAGCCTCTACGGCGATCCAAGAGAAGATGGGTTATCACCACCTTG
GAGCTGGAGGAGGAAGACCCGGGACCCTTTCCCAAACTCATTGGTGAGCTGTTCAATAATATGTCTTATAACATGTCACTAATGTATCTA
ATCAGTGGACCTGGTGTGGATGAATATCCAGAGATTGGTTTGTTTTCTCTAGAAGATCATGAGAACGGAAGGATATATGTTCACCGCCCT
GTCGATCGAGAAATGACACCATCTTTCACGGTTTATTTTGATGTTGTGGAGCGCTCAACAGGAAAAATTGTGGATACATCCTTGATTTTC
AACATTAGGATCAGTGATGTGAATGATCATGCACCCCAGTTTCCAGAGAAGGAATTTAACATCACTGTGCAAGAAAACCAATCTGCAGGG
CAACCTATTTTTCAGATGTTAGCAGTCGATTTGGATGAAGAAAACACTCCAAATTCTCAAGTCCTTTACTTCCTCATTTCTCAAACACCA
TTACTGAAAGAAAGTGGTTTCCGGGTTGATCGCCTTAGTGGAGAAATACGACTCTCTGGCTGCTTAGATTATGAGACCGCTCCTCAGTTT
ACACTGCTAATCAGAGCCAGGGACTGTGGAGAACCGTCACTGTCATCCACGACCACCGTTCACGTGGATGTGCAAGAAGGCAACAACCAC
AGGCCTGCATTTACCCAGGAGAACTATAAGGTTCAGATTCCTGAAGGCCGAGCCAGCCAGGGCGTGTTGCGTCTCCTGGTTCAAGATCGA
GATTCTCCATTTACATCAGCTTGGAGAGCAAAATTCAACATATTGCATGGCAATGAAGAGGGGCATTTTGACATTTCGACTGACCCTGAG
ACCAACGAAGGGATATTAAATGTTATCAAGCCTTTGGATTATGAGACTCGCCCAGCGCAAAGCCTCATCATTGTCGTGGAGAATGAGGAG
AGGCTCGTCTTCTGTGAGAGAGGAAAGCTTCAGCCGCCAAGGAAGGCAGCAGCCAGCGCCACTGTGAGTGTGCAGGTGACAGACGCCAAC
GACCCACCAGCCTTTCACCCCCAGAGCTTCATTGTCAATAAAGAGGAGGGCGCCAGGCCTGGGACCCTGTTGGGAACTTTTAATGCCATG
GATCCAGACAGCCAGATAAGATATGAACTGGTTCATGACCCAGCAAATTGGGTCAGCGTCGACAAAAACTCCGGAGTGGTCATCACCGTG
GAGCCAATTGACCGAGAATCCCCTCATGTAAATAACAGTTTTTATGTAATCATCATTCACGCTGTTGATGATGGCTTCCCACCGCAGACT
GCTACAGGGACCCTAATGCTCTTCCTGTCTGACATCAATGACAACGTCCCGACTCTCCGGCCACGTTCCCGCTACATGGAGGTCTGTGAG
TCTGCTGTGCATGAGCCCCTCCACATCGAGGCAGAGGATCCGGACCTGGAGCCGTTCTCTGACCCATTTACATTTGAATTGGACAATACC
TGGGGAAATGCGGAGGACACATGGAAGTTGGGGAGAAATTGGGGTCAATCAGTTGAACTTTTAACCTTGAGAAGCCTGCCACGTGGTAAT
TACTTGGTGCCACTCTTCATTGGAGACAAACAGGGACTTTCCCAGAAGCAAACTGTCCATGTAAGGATCTGCCCCTGTGCCAGTGGGCTC
ACATGTGTGGAGCTTGCAGATGCAGAAGTGGGGCTTCATGTGGGGGCCCTGTTCCCTGTCTGTGCAGCATTTGTGGCTCTGGCAGTGGCT
CTGCTTTTTCTGTTGCGATGCTATTTTGTGCTTGAACCTAAGAGGCATGGATGCTCTGTATCCAATGATGAAGGCCACCAAACACTGGTC
ATGTATAATGCGGAGAGCAAAGGCACTTCAGCCCAGACATGGTCAGATGTTGAAGGCCAGAGGCCGGCTCTGCTCATCTGCACAGCTGCA
GCAGGACCCACGCAGGGAGTTAAGGCTTACCCAGATGCCACAATGCACAGACAACTCCTGGCTCCGGTGGAAGGAAGGATGGCAGAGACA
TTGAATCAGTCTAAAGAGAGAAATCGCTTCAGCCTCAGCAGGGGCTGCATCATCCCCCAGGGAAGAGCCACAGCTGGGCGAGGATTGCCA
CAAGACATTTACAAGGAGATGATGCCACGGAGACTAACGCAGACTGGTAAACGGAAACACGGGGCTTTGGCTCGAACACCCTCTTTCAAG
AAAGTTGTTTATGACCACAAGGAAGATGAGGAGAACAAGGCTGGGAGAAAGCAAAGGAGCCACTTGTTTAAGGTTATGCAGCTGAGAAAT
GAACAAGGTGGGGTTCGAGTCCAGAGTGCGCATTCCCCATCACCCCTTAACAAAAAGGCATGTTTCCCAGGAGACTACAGAGGAGAATCG

>95994_95994_2_UBE2C-CDH26_UBE2C_chr20_44443109_ENST00000356455_CDH26_chr20_58544022_ENST00000244047_length(amino acids)=939AA_BP=110
MIGRRPQRVTIQTRAGGPAVLQLQSCSPSSCLSANAARMASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISA
FPESDNLFKWVGTIHGAAGTVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPFPKLIGELFNNMSYNMSLMYLIS
GPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAGQP
IFQMLAVDLDEENTPNSQVLYFLISQTPLLKESGFRVDRLSGEIRLSGCLDYETAPQFTLLIRARDCGEPSLSSTTTVHVDVQEGNNHRP
AFTQENYKVQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVENEERL
VFCERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIVNKEEGARPGTLLGTFNAMDPDSQIRYELVHDPANWVSVDKNSGVVITVEP
IDRESPHVNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDLEPFSDPFTFELDNTWG
NAEDTWKLGRNWGQSVELLTLRSLPRGNYLVPLFIGDKQGLSQKQTVHVRICPCASGLTCVELADAEVGLHVGALFPVCAAFVALAVALL
FLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKGTSAQTWSDVEGQRPALLICTAAAGPTQGVKAYPDATMHRQLLAPVEGRMAETLN
QSKERNRFSLSRGCIIPQGRATAGRGLPQDIYKEMMPRRLTQTGKRKHGALARTPSFKKVVYDHKEDEENKAGRKQRSHLFKVMQLRNEQ

--------------------------------------------------------------
>95994_95994_3_UBE2C-CDH26_UBE2C_chr20_44443109_ENST00000372568_CDH26_chr20_58544022_ENST00000244047_length(transcript)=2890nt_BP=400nt
GGTGAGATTCGAGAGATGGGGGACAGGCCAGGAGCTCAGACCGCTCTTTGAGACTCTCCCGAAGGAGAATGGGAGGGTAGGGGCGCTGCC
AGACTCCTTCCCTGGTGGGCCTAGATGAAGACGCTCAAGGACCCTCGTGACTTGGCCGAGACAGGGGAAGGGAGAAGTTGAGTCGGGCAA
GGAAGAGATGCTAAAGCCTGGGGAATTAAGAACATGCCAGAATCATCCCGAGGGAGTCTGGAATTAGGGAGGGTGAGGACTCGCTAGGAT
CGTCCTGTGGATCTGGCTACAGCAGGAGCTGATGACCCTCATGATGTCTGGCGATAAAGGGATTTCTGCCTTCCCTGAATCAGACAACCT
TTTCAAATGGGTAGGGACCATCCATGGAGCAGCTGGAACAGTCAGTATCATTGACAGTGTTCAACAGGAAACAGATGATCTTACTAAGCA
AACAAAGGAAAAGATCTACCAGCCTCTACGGCGATCCAAGAGAAGATGGGTTATCACCACCTTGGAGCTGGAGGAGGAAGACCCGGGACC
CTTTCCCAAACTCATTGGTGAGCTGTTCAATAATATGTCTTATAACATGTCACTAATGTATCTAATCAGTGGACCTGGTGTGGATGAATA
TCCAGAGATTGGTTTGTTTTCTCTAGAAGATCATGAGAACGGAAGGATATATGTTCACCGCCCTGTCGATCGAGAAATGACACCATCTTT
CACGGTTTATTTTGATGTTGTGGAGCGCTCAACAGGAAAAATTGTGGATACATCCTTGATTTTCAACATTAGGATCAGTGATGTGAATGA
TCATGCACCCCAGTTTCCAGAGAAGGAATTTAACATCACTGTGCAAGAAAACCAATCTGCAGGGCAACCTATTTTTCAGATGTTAGCAGT
CGATTTGGATGAAGAAAACACTCCAAATTCTCAAGTCCTTTACTTCCTCATTTCTCAAACACCATTACTGAAAGAAAGTGGTTTCCGGGT
TGATCGCCTTAGTGGAGAAATACGACTCTCTGGCTGCTTAGATTATGAGACCGCTCCTCAGTTTACACTGCTAATCAGAGCCAGGGACTG
TGGAGAACCGTCACTGTCATCCACGACCACCGTTCACGTGGATGTGCAAGAAGGCAACAACCACAGGCCTGCATTTACCCAGGAGAACTA
TAAGGTTCAGATTCCTGAAGGCCGAGCCAGCCAGGGCGTGTTGCGTCTCCTGGTTCAAGATCGAGATTCTCCATTTACATCAGCTTGGAG
AGCAAAATTCAACATATTGCATGGCAATGAAGAGGGGCATTTTGACATTTCGACTGACCCTGAGACCAACGAAGGGATATTAAATGTTAT
CAAGCCTTTGGATTATGAGACTCGCCCAGCGCAAAGCCTCATCATTGTCGTGGAGAATGAGGAGAGGCTCGTCTTCTGTGAGAGAGGAAA
GCTTCAGCCGCCAAGGAAGGCAGCAGCCAGCGCCACTGTGAGTGTGCAGGTGACAGACGCCAACGACCCACCAGCCTTTCACCCCCAGAG
CTTCATTGTCAATAAAGAGGAGGGCGCCAGGCCTGGGACCCTGTTGGGAACTTTTAATGCCATGGATCCAGACAGCCAGATAAGATATGA
ACTGGTTCATGACCCAGCAAATTGGGTCAGCGTCGACAAAAACTCCGGAGTGGTCATCACCGTGGAGCCAATTGACCGAGAATCCCCTCA
TGTAAATAACAGTTTTTATGTAATCATCATTCACGCTGTTGATGATGGCTTCCCACCGCAGACTGCTACAGGGACCCTAATGCTCTTCCT
GTCTGACATCAATGACAACGTCCCGACTCTCCGGCCACGTTCCCGCTACATGGAGGTCTGTGAGTCTGCTGTGCATGAGCCCCTCCACAT
CGAGGCAGAGGATCCGGACCTGGAGCCGTTCTCTGACCCATTTACATTTGAATTGGACAATACCTGGGGAAATGCGGAGGACACATGGAA
GTTGGGGAGAAATTGGGGTCAATCAGTTGAACTTTTAACCTTGAGAAGCCTGCCACGTGGTAATTACTTGGTGCCACTCTTCATTGGAGA
CAAACAGGGACTTTCCCAGAAGCAAACTGTCCATGTAAGGATCTGCCCCTGTGCCAGTGGGCTCACATGTGTGGAGCTTGCAGATGCAGA
AGTGGGGCTTCATGTGGGGGCCCTGTTCCCTGTCTGTGCAGCATTTGTGGCTCTGGCAGTGGCTCTGCTTTTTCTGTTGCGATGCTATTT
TGTGCTTGAACCTAAGAGGCATGGATGCTCTGTATCCAATGATGAAGGCCACCAAACACTGGTCATGTATAATGCGGAGAGCAAAGGCAC
TTCAGCCCAGACATGGTCAGATGTTGAAGGCCAGAGGCCGGCTCTGCTCATCTGCACAGCTGCAGCAGGACCCACGCAGGGAGTTAAGGC
TTACCCAGATGCCACAATGCACAGACAACTCCTGGCTCCGGTGGAAGGAAGGATGGCAGAGACATTGAATCAGTCTAAAGAGAGAAATCG
CTTCAGCCTCAGCAGGGGCTGCATCATCCCCCAGGGAAGAGCCACAGCTGGGCGAGGATTGCCACAAGACATTTACAAGGAGATGATGCC
ACGGAGACTAACGCAGACTGGTAAACGGAAACACGGGGCTTTGGCTCGAACACCCTCTTTCAAGAAAGTTGTTTATGACCACAAGGAAGA
TGAGGAGAACAAGGCTGGGAGAAAGCAAAGGAGCCACTTGTTTAAGGTTATGCAGCTGAGAAATGAACAAGGTGGGGTTCGAGTCCAGAG
TGCGCATTCCCCATCACCCCTTAACAAAAAGGCATGTTTCCCAGGAGACTACAGAGGAGAATCGGCAGGTGGTCACAATTGCAGGGCTGT

>95994_95994_3_UBE2C-CDH26_UBE2C_chr20_44443109_ENST00000372568_CDH26_chr20_58544022_ENST00000244047_length(amino acids)=872AA_BP=42
MWIWLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPF
PKLIGELFNNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDH
APQFPEKEFNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKESGFRVDRLSGEIRLSGCLDYETAPQFTLLIRARDCG
EPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIK
PLDYETRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIVNKEEGARPGTLLGTFNAMDPDSQIRYEL
VHDPANWVSVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIE
AEDPDLEPFSDPFTFELDNTWGNAEDTWKLGRNWGQSVELLTLRSLPRGNYLVPLFIGDKQGLSQKQTVHVRICPCASGLTCVELADAEV
GLHVGALFPVCAAFVALAVALLFLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKGTSAQTWSDVEGQRPALLICTAAAGPTQGVKAY
PDATMHRQLLAPVEGRMAETLNQSKERNRFSLSRGCIIPQGRATAGRGLPQDIYKEMMPRRLTQTGKRKHGALARTPSFKKVVYDHKEDE

--------------------------------------------------------------
>95994_95994_4_UBE2C-CDH26_UBE2C_chr20_44443109_ENST00000405520_CDH26_chr20_58544022_ENST00000244047_length(transcript)=3426nt_BP=936nt
AAACGCGGGCGGGCGGGCCCGCAGTCCTGCAGTTGCAGTCGTGTTCTCCGAGTTCCTGTCTCTCTGCCAACGCCGCCCGGATGGCTTCCC
AAAACCGCGACCCAGCCGCCACTAGCGTCGCCGCCGCCCGTAAAGGAGCTGAGCCGAGCGGGGGCGCCGCCCGGGGTCCGGTGGGCAAAA
GGTGAGTGATGCGGCCTACCACTCGCCGGGCCTGCCATGCCCTAGGCATTGGTACCCAGAGCAAAGATTTCTAGGACCACCCCCCGCCGC
CACCTCCTGGAGCGGGAGATCTGCGGGTGCAGGAGAACACACCAGGAGCTCGGGGCCTGGCATTCCCCTGGGCATGGGTGTCGAGGGCGG
AGACTTCCGGGACTCCCACCTCCTTGCGCGGGTGAGATTCGAGAGATGGGGGACAGGCCAGGAGCTCAGACCGCTCTTTGAGACTCTCCC
GAAGGAGAATGGGAGGGTAGGGGCGCTGCCAGACTCCTTCCCTGGTGGGCCTAGATGAAGACGCTCAAGGACCCTCGTGACTTGGCCGAG
ACAGGGGAAGGGAGAAGTTGAGTCGGGCAAGGAAGAGATGCTAAAGCCTGGGGAATTAAGAACATGCCAGAATCATCCCGAGGGAGTCTG
GAATTAGGGAGGGTGAGGACTCGCTAGGATCGTCCTGTGGATCTGGTGAGTATACCCTGAGCTGAGCCTGACCTTGGTGATGTGGGGAGC
CTCCATGACGGCTCCCCCTGAGATTCAGGTGGGAGAAGATGCACCGTCTGGAGGCCTGGCCCATCCAGACTCCCAGGTAACCCCGAATAC
TCTTTTTTCAGGCTACAGCAGGAGCTGATGACCCTCATGATGTCTGGCGATAAAGGGATTTCTGCCTTCCCTGAATCAGACAACCTTTTC
AAATGGGTAGGGACCATCCATGGAGCAGCTGGAACAGTCAGTATCATTGACAGTGTTCAACAGGAAACAGATGATCTTACTAAGCAAACA
AAGGAAAAGATCTACCAGCCTCTACGGCGATCCAAGAGAAGATGGGTTATCACCACCTTGGAGCTGGAGGAGGAAGACCCGGGACCCTTT
CCCAAACTCATTGGTGAGCTGTTCAATAATATGTCTTATAACATGTCACTAATGTATCTAATCAGTGGACCTGGTGTGGATGAATATCCA
GAGATTGGTTTGTTTTCTCTAGAAGATCATGAGAACGGAAGGATATATGTTCACCGCCCTGTCGATCGAGAAATGACACCATCTTTCACG
GTTTATTTTGATGTTGTGGAGCGCTCAACAGGAAAAATTGTGGATACATCCTTGATTTTCAACATTAGGATCAGTGATGTGAATGATCAT
GCACCCCAGTTTCCAGAGAAGGAATTTAACATCACTGTGCAAGAAAACCAATCTGCAGGGCAACCTATTTTTCAGATGTTAGCAGTCGAT
TTGGATGAAGAAAACACTCCAAATTCTCAAGTCCTTTACTTCCTCATTTCTCAAACACCATTACTGAAAGAAAGTGGTTTCCGGGTTGAT
CGCCTTAGTGGAGAAATACGACTCTCTGGCTGCTTAGATTATGAGACCGCTCCTCAGTTTACACTGCTAATCAGAGCCAGGGACTGTGGA
GAACCGTCACTGTCATCCACGACCACCGTTCACGTGGATGTGCAAGAAGGCAACAACCACAGGCCTGCATTTACCCAGGAGAACTATAAG
GTTCAGATTCCTGAAGGCCGAGCCAGCCAGGGCGTGTTGCGTCTCCTGGTTCAAGATCGAGATTCTCCATTTACATCAGCTTGGAGAGCA
AAATTCAACATATTGCATGGCAATGAAGAGGGGCATTTTGACATTTCGACTGACCCTGAGACCAACGAAGGGATATTAAATGTTATCAAG
CCTTTGGATTATGAGACTCGCCCAGCGCAAAGCCTCATCATTGTCGTGGAGAATGAGGAGAGGCTCGTCTTCTGTGAGAGAGGAAAGCTT
CAGCCGCCAAGGAAGGCAGCAGCCAGCGCCACTGTGAGTGTGCAGGTGACAGACGCCAACGACCCACCAGCCTTTCACCCCCAGAGCTTC
ATTGTCAATAAAGAGGAGGGCGCCAGGCCTGGGACCCTGTTGGGAACTTTTAATGCCATGGATCCAGACAGCCAGATAAGATATGAACTG
GTTCATGACCCAGCAAATTGGGTCAGCGTCGACAAAAACTCCGGAGTGGTCATCACCGTGGAGCCAATTGACCGAGAATCCCCTCATGTA
AATAACAGTTTTTATGTAATCATCATTCACGCTGTTGATGATGGCTTCCCACCGCAGACTGCTACAGGGACCCTAATGCTCTTCCTGTCT
GACATCAATGACAACGTCCCGACTCTCCGGCCACGTTCCCGCTACATGGAGGTCTGTGAGTCTGCTGTGCATGAGCCCCTCCACATCGAG
GCAGAGGATCCGGACCTGGAGCCGTTCTCTGACCCATTTACATTTGAATTGGACAATACCTGGGGAAATGCGGAGGACACATGGAAGTTG
GGGAGAAATTGGGGTCAATCAGTTGAACTTTTAACCTTGAGAAGCCTGCCACGTGGTAATTACTTGGTGCCACTCTTCATTGGAGACAAA
CAGGGACTTTCCCAGAAGCAAACTGTCCATGTAAGGATCTGCCCCTGTGCCAGTGGGCTCACATGTGTGGAGCTTGCAGATGCAGAAGTG
GGGCTTCATGTGGGGGCCCTGTTCCCTGTCTGTGCAGCATTTGTGGCTCTGGCAGTGGCTCTGCTTTTTCTGTTGCGATGCTATTTTGTG
CTTGAACCTAAGAGGCATGGATGCTCTGTATCCAATGATGAAGGCCACCAAACACTGGTCATGTATAATGCGGAGAGCAAAGGCACTTCA
GCCCAGACATGGTCAGATGTTGAAGGCCAGAGGCCGGCTCTGCTCATCTGCACAGCTGCAGCAGGACCCACGCAGGGAGTTAAGGCTTAC
CCAGATGCCACAATGCACAGACAACTCCTGGCTCCGGTGGAAGGAAGGATGGCAGAGACATTGAATCAGTCTAAAGAGAGAAATCGCTTC
AGCCTCAGCAGGGGCTGCATCATCCCCCAGGGAAGAGCCACAGCTGGGCGAGGATTGCCACAAGACATTTACAAGGAGATGATGCCACGG
AGACTAACGCAGACTGGTAAACGGAAACACGGGGCTTTGGCTCGAACACCCTCTTTCAAGAAAGTTGTTTATGACCACAAGGAAGATGAG
GAGAACAAGGCTGGGAGAAAGCAAAGGAGCCACTTGTTTAAGGTTATGCAGCTGAGAAATGAACAAGGTGGGGTTCGAGTCCAGAGTGCG
CATTCCCCATCACCCCTTAACAAAAAGGCATGTTTCCCAGGAGACTACAGAGGAGAATCGGCAGGTGGTCACAATTGCAGGGCTGTCTCA

>95994_95994_4_UBE2C-CDH26_UBE2C_chr20_44443109_ENST00000405520_CDH26_chr20_58544022_ENST00000244047_length(amino acids)=863AA_BP=34
MMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVSIIDSVQQETDDLTKQTKEKIYQPLRRSKRRWVITTLELEEEDPGPFPKLIGELF
NNMSYNMSLMYLISGPGVDEYPEIGLFSLEDHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKE
FNITVQENQSAGQPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKESGFRVDRLSGEIRLSGCLDYETAPQFTLLIRARDCGEPSLSSTT
TVHVDVQEGNNHRPAFTQENYKVQIPEGRASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRP
AQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDANDPPAFHPQSFIVNKEEGARPGTLLGTFNAMDPDSQIRYELVHDPANWV
SVDKNSGVVITVEPIDRESPHVNNSFYVIIIHAVDDGFPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAVHEPLHIEAEDPDLEP
FSDPFTFELDNTWGNAEDTWKLGRNWGQSVELLTLRSLPRGNYLVPLFIGDKQGLSQKQTVHVRICPCASGLTCVELADAEVGLHVGALF
PVCAAFVALAVALLFLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKGTSAQTWSDVEGQRPALLICTAAAGPTQGVKAYPDATMHRQ
LLAPVEGRMAETLNQSKERNRFSLSRGCIIPQGRATAGRGLPQDIYKEMMPRRLTQTGKRKHGALARTPSFKKVVYDHKEDEENKAGRKQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UBE2C-CDH26

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for UBE2C-CDH26

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for UBE2C-CDH26

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source