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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UBE2D3-SLC9B1 (FusionGDB2 ID:96037)

Fusion Gene Summary for UBE2D3-SLC9B1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2D3-SLC9B1
Fusion gene ID: 96037
HgeneTgene
Gene symbol

UBE2D3

SLC9B1

Gene ID

7323

150159

Gene nameubiquitin conjugating enzyme E2 D3solute carrier family 9 member B1
SynonymsE2(17)KB3|UBC4/5|UBCH5CNHA1|NHEDC1
Cytomap

4q24

4q24

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 D3(E3-independent) E2 ubiquitin-conjugating enzyme D3E2 ubiquitin-conjugating enzyme D3ubiquitin carrier protein D3ubiquitin conjugating enzyme E2D 3ubiquitin-conjugating enzyme E2(17)KB 3ubiquitin-conjugating enzyme sodium/hydrogen exchanger 9B1NHE domain-containing protein 1Na(+)/H(+) exchanger-like domain-containing protein 1sodium/hydrogen exchanger-like domain-containing protein 1solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000357194, ENST00000338145, 
ENST00000321805, ENST00000343106, 
ENST00000349311, ENST00000350435, 
ENST00000394801, ENST00000394803, 
ENST00000394804, ENST00000453744, 
ENST00000502404, ENST00000504211, 
ENST00000505207, ENST00000507845, 
ENST00000513098, 		ENST00000296422, 
ENST00000394789, ENST00000512651, 
Fusion gene scores* DoF score12 X 14 X 7=11763 X 4 X 3=36
# samples 175
** MAII scorelog2(17/1176*10)=-2.79028140869866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBE2D3 [Title/Abstract] AND SLC9B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBE2D3(103789872)-SLC9B1(103832694), # samples:3
Anticipated loss of major functional domain due to fusion event.UBE2D3-SLC9B1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
UBE2D3-SLC9B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
UBE2D3-SLC9B1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2D3

GO:0000209

protein polyubiquitination

14765125|16522193

HgeneUBE2D3

GO:0006513

protein monoubiquitination

20347421

HgeneUBE2D3

GO:0016567

protein ubiquitination

9990509|21532592

HgeneUBE2D3

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

HgeneUBE2D3

GO:0051865

protein autoubiquitination

21068390

HgeneUBE2D3

GO:0070936

protein K48-linked ubiquitination

20061386

HgeneUBE2D3

GO:0070979

protein K11-linked ubiquitination

20061386


check buttonFusion gene breakpoints across UBE2D3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC9B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GC-A3RB-01AUBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
ChimerDB4BRCATCGA-E9-A1NA-01AUBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
ChimerDB4BRCATCGA-E9-A1NAUBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
ChimerDB4LUSCTCGA-66-2771-01AUBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
ChimerDB4LUSCTCGA-66-2771UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-


Top

Fusion Gene ORF analysis for UBE2D3-SLC9B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000357194ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
5CDS-5UTRENST00000357194ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
5CDS-5UTRENST00000357194ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
5CDS-5UTRENST00000357194ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
5CDS-intronENST00000357194ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
5CDS-intronENST00000357194ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
5CDS-intronENST00000357194ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
5UTR-3CDSENST00000338145ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
5UTR-3CDSENST00000338145ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
5UTR-5UTRENST00000338145ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
5UTR-5UTRENST00000338145ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
5UTR-5UTRENST00000338145ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
5UTR-5UTRENST00000338145ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
5UTR-intronENST00000338145ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
5UTR-intronENST00000338145ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
5UTR-intronENST00000338145ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
Frame-shiftENST00000357194ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
Frame-shiftENST00000357194ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000321805ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000321805ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000343106ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000343106ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000349311ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000349311ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000350435ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000350435ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000394801ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000394801ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000394803ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000394803ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000394804ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000394804ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000453744ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000453744ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000502404ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000502404ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000504211ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000504211ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000505207ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000505207ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000507845ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000507845ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000513098ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-3CDSENST00000513098ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-5UTRENST00000321805ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000321805ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000321805ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000321805ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000343106ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000343106ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000343106ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000343106ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000349311ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000349311ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000349311ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000349311ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000350435ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000350435ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000350435ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000350435ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394801ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394801ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394801ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394801ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394803ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394803ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394803ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394803ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394804ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394804ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394804ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000394804ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000453744ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000453744ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000453744ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000453744ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000502404ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000502404ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000502404ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000502404ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000504211ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000504211ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000504211ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000504211ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000505207ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000505207ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000505207ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000505207ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000507845ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000507845ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000507845ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000507845ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000513098ENST00000296422UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000513098ENST00000296422UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-5UTRENST00000513098ENST00000394789UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-5UTRENST00000513098ENST00000394789UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000321805ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000321805ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000321805ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000343106ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000343106ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000343106ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000349311ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000349311ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000349311ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000350435ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000350435ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000350435ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000394801ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000394801ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000394801ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000394803ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000394803ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000394803ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000394804ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000394804ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000394804ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000453744ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000453744ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000453744ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000502404ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000502404ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000502404ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000504211ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000504211ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000504211ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000505207ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000505207ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000505207ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000507845ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000507845ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000507845ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-
intron-intronENST00000513098ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103832694

-
intron-intronENST00000513098ENST00000512651UBE2D3chr4

103789872

-SLC9B1chr4

103912869

-
intron-intronENST00000513098ENST00000512651UBE2D3chr4

103789871

-SLC9B1chr4

103912869

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for UBE2D3-SLC9B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBE2D3-SLC9B1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:103789872/:103832694)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for UBE2D3-SLC9B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for UBE2D3-SLC9B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UBE2D3-SLC9B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UBE2D3-SLC9B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource