FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:UBE2E3-METTL8 (FusionGDB2 ID:96075)

Fusion Gene Summary for UBE2E3-METTL8

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2E3-METTL8
Fusion gene ID: 96075
HgeneTgene
Gene symbol

UBE2E3

METTL8

Gene ID

10477

79828

Gene nameubiquitin conjugating enzyme E2 E3methyltransferase like 8
SynonymsUBCH9|UbcM2TIP
Cytomap

2q31.3

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 E3E2 ubiquitin-conjugating enzyme E3ubiquitin carrier protein E3ubiquitin conjugating enzyme E2E 3ubiquitin-conjugating enzyme E2-23 kDaubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)ubiquitin-conjugating emRNA N(3)-methylcytidine methyltransferase METTL8methyltransferase-like protein 8tension-induced/inhibited protein
Modification date2020031320200313
UniProtAcc.

Q9H825

Ensembl transtripts involved in fusion geneENST00000392415, ENST00000410062, 
ENST00000602475, ENST00000602632, 
ENST00000602710, ENST00000602959, 
ENST00000602837, 		ENST00000463392, 
ENST00000375258, 
Fusion gene scores* DoF score10 X 6 X 6=3604 X 3 X 4=48
# samples 104
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE2E3 [Title/Abstract] AND METTL8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBE2E3(181848820)-METTL8(172217023), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2E3

GO:0070534

protein K63-linked ubiquitination

20061386

HgeneUBE2E3

GO:0070936

protein K48-linked ubiquitination

20061386

HgeneUBE2E3

GO:0070979

protein K11-linked ubiquitination

20061386


check buttonFusion gene breakpoints across UBE2E3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across METTL8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A9FOUBE2E3chr2

181848820

+METTL8chr2

172217023

-


Top

Fusion Gene ORF analysis for UBE2E3-METTL8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000392415ENST00000463392UBE2E3chr2

181848820

+METTL8chr2

172217023

-
5CDS-intronENST00000410062ENST00000463392UBE2E3chr2

181848820

+METTL8chr2

172217023

-
5CDS-intronENST00000602475ENST00000463392UBE2E3chr2

181848820

+METTL8chr2

172217023

-
5CDS-intronENST00000602632ENST00000463392UBE2E3chr2

181848820

+METTL8chr2

172217023

-
5CDS-intronENST00000602710ENST00000463392UBE2E3chr2

181848820

+METTL8chr2

172217023

-
5CDS-intronENST00000602959ENST00000463392UBE2E3chr2

181848820

+METTL8chr2

172217023

-
In-frameENST00000392415ENST00000375258UBE2E3chr2

181848820

+METTL8chr2

172217023

-
In-frameENST00000410062ENST00000375258UBE2E3chr2

181848820

+METTL8chr2

172217023

-
In-frameENST00000602475ENST00000375258UBE2E3chr2

181848820

+METTL8chr2

172217023

-
In-frameENST00000602632ENST00000375258UBE2E3chr2

181848820

+METTL8chr2

172217023

-
In-frameENST00000602710ENST00000375258UBE2E3chr2

181848820

+METTL8chr2

172217023

-
In-frameENST00000602959ENST00000375258UBE2E3chr2

181848820

+METTL8chr2

172217023

-
intron-3CDSENST00000602837ENST00000375258UBE2E3chr2

181848820

+METTL8chr2

172217023

-
intron-intronENST00000602837ENST00000463392UBE2E3chr2

181848820

+METTL8chr2

172217023

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392415UBE2E3chr2181848820+ENST00000375258METTL8chr2172217023-8307463351456473
ENST00000410062UBE2E3chr2181848820+ENST00000375258METTL8chr2172217023-84826383931631412
ENST00000602710UBE2E3chr2181848820+ENST00000375258METTL8chr2172217023-84686243791617412
ENST00000602959UBE2E3chr2181848820+ENST00000375258METTL8chr2172217023-82333891441382412
ENST00000602475UBE2E3chr2181848820+ENST00000375258METTL8chr2172217023-82814371921430412
ENST00000602632UBE2E3chr2181848820+ENST00000375258METTL8chr2172217023-8109265201258412

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392415ENST00000375258UBE2E3chr2181848820+METTL8chr2172217023-0.0003682990.99963164
ENST00000410062ENST00000375258UBE2E3chr2181848820+METTL8chr2172217023-0.0003816280.9996183
ENST00000602710ENST00000375258UBE2E3chr2181848820+METTL8chr2172217023-0.0003614010.99963856
ENST00000602959ENST00000375258UBE2E3chr2181848820+METTL8chr2172217023-0.0003628010.9996371
ENST00000602475ENST00000375258UBE2E3chr2181848820+METTL8chr2172217023-0.0003634570.99963653
ENST00000602632ENST00000375258UBE2E3chr2181848820+METTL8chr2172217023-0.0003654440.9996345

Top

Fusion Genomic Features for UBE2E3-METTL8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for UBE2E3-METTL8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:181848820/chr2:172217023)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.METTL8

Q9H825

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs. {ECO:0000269|PubMed:28655767}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBE2E3chr2:181848820chr2:172217023ENST00000392415+3661_20781208.0DomainUBC core
HgeneUBE2E3chr2:181848820chr2:172217023ENST00000410062+3661_20781208.0DomainUBC core
HgeneUBE2E3chr2:181848820chr2:172217023ENST00000602710+3661_20781208.0DomainUBC core
HgeneUBE2E3chr2:181848820chr2:172217023ENST00000602959+4761_20781208.0DomainUBC core


Top

Fusion Gene Sequence for UBE2E3-METTL8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96075_96075_1_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000392415_METTL8_chr2_172217023_ENST00000375258_length(transcript)=8307nt_BP=463nt
GCAGGGGCCAGCCCGCCGGGTCCCCGCCGCGCTCTTTGTCCTGGCCGCGCGCGGGCGGACGCGTGCACCCCCAGGGTGAGGGGAGGTGTG
GAGAGCGCGCACGGGAGCGCGCGGGAACAGCTCGCGCCCGCCGGGCGTCGGCGGCGCGCGCCCCTCCGCCAGGCAAGCAGCGAGCACGCG
CGTCGCCGCCGAGTTTTCCAAGAGATAACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTG
GCAGTTCAGATGCGGACCAGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCCACCCAGCAGAAGAAAA
ACACCAAACTCTCTAGCAAAACCACTGCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTC
CTCCTAATTGCAGGGATCACATGCAGTGGTCTAAGGAAGAAGAAGCAGCAGCCAGAAAAAAAGTAAAAGAAAACTCAGCTGTGCGAGTCC
TTCTGGAAGAGCAAGTTAAGTATGAGAGAGAAGCTAGTAAATACTGGGACACATTTTACAAGATTCATAAGAATAAGTTTTTCAAGGATC
GTAATTGGCTGTTGAGGGAATTTCCTGAAATTCTTCCAGTTGATCAAAAACCTGAAGAGAAGGCGAGAGAATCATCATGGGATCATGTAA
AAACTAGTGCTACAAATCGTTTCTCAAGAATGCACTGTCCTACTGTGCCTGATGAAAAAAATCATTATGAGAAAAGTTCTGGTTCTTCAG
AAGGTCAAAGCAAAACAGAATCTGATTTTTCCAACCTAGACTCTGAAAAACACAAAAAAGGACCTATGGAGACTGGATTGTTTCCTGGTA
GCAATGCCACTTTCAGGATACTAGAGGTTGGTTGTGGAGCTGGAAATAGTGTGTTTCCAATTTTGAACACTTTGGAGAACTCTCCGGAGT
CCTTTCTGTATTGTTGTGATTTTGCTTCTGGAGCTGTGGAGCTCGTAAAGTCACACTCGTCCTACAGAGCAACCCAGTGTTTTGCCTTTG
TTCATGATGTATGTGATGATGGCTTACCTTACCCTTTTCCAGATGGGATCCTGGATGTCATTCTCCTTGTCTTTGTGCTCTCTTCTATTC
ATCCTGACAGGATGCAAGGTGTTGTAAACCGACTGTCCAAGTTACTGAAACCTGGGGGAATGCTGTTATTTCGAGACTATGGAAGATATG
ATAAGACTCAGCTTCGTTTTAAAAAGGGACATTGTTTATCTGAAAATTTTTATGTTCGAGGAGATGGTACCAGAGCATATTTCTTTACAA
AAGGGGAAGTCCACAGTATGTTCTGCAAAGCCAGTTTAGATGAAAAGCAAAATCTGGTTGATCGCCGCTTACAAGTTAATAGGAAAAAAC
AAGTGAAAATGCACTGAGTGTGGATTCAAGGCAAATTCCAGAAACCATTGCACCAGACTCAGAATAGCTCCAATATGGTATCTACACTCC
TTTCACAAGACTGAACTTTGTAACATGTTAAGGTACAAAGCCAGAGGACTGTGCTATTCAAGGACTACTGTAAGTCTATTGTTTCTCAAA
AGACAATGAGAAAAAAAGAAGAGAATTTGTATTTCCTGCCGTTTTGTCATAGGTGAGCTCCTTTGTGCATTTTAAGCACATGTAAGTGGT
TCAGCACAGTATGCCTTTTTCTGTGCTTTGAAAACTTGATATGCTCAAGCTTGTTTGAATTTATTACATCTAACCATTTTGCTTGTTCCT
TGATTTTTATAAGCATTCAATTAAGTTAGTATTATGTCAAGTAATTTTGAGAAAATGTAACTTGACATTTTTTGCAAGTAAAAAAAATTG
TTTATTTGTTTAGGCTTAGTAAACCAGTTCCCAAACACAGTCAGACTCTTCCCATTGTCATCTGATTGCAGAGAGAAAGCACACCTTATT
TCCAGGGAAAGCTACAACAAGCCCAAGGTCAAAGTGTATTATTTTTTGTCTTGTTGTTGTCTATTTTCTCCCAATTTTTTTTTGAAATTC
AGAGGCTCATATCTGAAATAGAATTTTAGTTCCTCTTTCCTTTCCTAAAATTGGGGAAGTACAGCCCATGCTGACATTATTTTCAGGCTA
TTCTTAGATATACAAGTTGTTAGGCCAGGTGCAATGGCTCGCACCTGTAATCCCAGCACTTTGGGGGGCTGAGGCAGGCAGATCGGTTGA
GCTCAGGAGTTCAAGACCAGCCTGGACAACATGGCAAAACCCTGTCTCTCCCAAGAATACAAAAATTAGCCAGGCATGGTGGCACACACC
TGTGGTCCCAGCTACTCAGGAGACTGAGGTGGGAGGATCGCTTGAGCCTCGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTACCACTGCG
CTCCAAACTGGGTGACATGGTGAGACCTTGTCTCCAAAAAAAAAAAAAAAAAAAAAAAAGGTATGTAAGCTGACAAGCTCTTGTATCAAG
GGCTTTTGAACCAGAGCAACTTCATCTTGAATAGGGACTGTGTAAAATGAAGCTGAGACCTACTAGGCTGCAATCCCAGGAGGTTAAGAC
ATTCTTAGTCACAGGATGAGATAGGAAGTCAGTACAAGATACAGGTCATACAGACCTTGCTGATAAAACAGGTTGCAGTGAAGAAGCCGG
CCAAATGCCACCAAAACCAAGATGGCAATGAGAGTGTCCTCTGGCTGTCCTCACTGCTACACTCCCACCAGTGCCATGATAGTTTACAAA
TGCCATGGCAACATCAGGAAGTTACCCATATGGTCTACAAAGGGGAGGCCTGAATAATCCACCCCTTGTGTAGCATATAATCAAGAAATA
ACCTTAAAAATGGGCAACCAGTAGCCCTTGGGGCTGCTCTGCCTATGGAGTAGCCATTCTTTATGTTTTACTTTTTTTTTTTTTTTTTTT
TTGAGATGGAGTCTTGCTCTGGCACCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCCAGCTCCACCTCCCGGGTTCACGCCAT
TCTCTTGCTTCAGCCTCCTGAGTAGCTGGGACTACAAGCACCCACCACCATGCCCAGCTAATTTTTTTTTTTTTTGTATTTTTAGTAGAG
ACGGGGTTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGG
TGTGAGCCACCGCGCCCAGCCTATTCTTTACTTAAACTTGTTTTCACTTTGCTGTATGGACTCAATTCTTTCTTGCACAAGATCCAAGAA
TCCTCTCTTGGCGTCTGGATCCAGACCCTTTCTGGTATCAGTGGTAAGCTCTGTTTAAGACAACTGTCATACCCAAGAGAATTCTTAAAT
TGTGGCAGTTAAAAATGTATTTATCCCCTCGAGGGCCGGGCGCAGTCGCTCAAGCCCGTAATCCCAGCACTTTGGGAGGCCGAGGAGGCG
GATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACACTGTGAAACCCTGTCTCTACTAAAAATACAAAAAAAATTAGCCAGGCGTGG
TGGTGGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATG
ACACCACTGCCCTCCAGCCTGGGTGACAGTTGTTAGACTGCGTATCAAAAAAAAAAAAAAAAATTTATTTACTCCCTTGCTTCAAAAAGG
ACATAAGTTGGCTTGCAAATCACATTTTGTAGAAATGAAGTTTTTAAGATTAGTCTCATACTCATTACATAATATTTATTGACTACTTAC
ATATTGAGTGCTAAATTCAGTGGAATAATATGAACAATAAAGACCCAGCCTTGTTTATGCTCTTCAGGGAGCATAAATAGAGTACAGCTG
GCAAAACAAAATGTGCATATCCCAAACCTGTAAATCATGATCTAAGACAATATACAAACACTCAAATAGGGAACTTACCAGCTAGCAGAC
TTTGATTATGAACCACAGAACCTAGAATAAATAAATACTCTCTTGAAAGAACCATCATTGGAATAATTAAGTTCCAACTGTTTTTTCTTT
CTGAATTCACTTAAAATCCAATTTCTAGAAGAATATCATTGGTCCAGCTTTAGTCATTGGTTCATCTCTTAACAGGCTGGGGCAGGGCAG
CTTAATTGATGATGCCACCAGAATGGGCAACATGGGAAAAACCCTATCTCTACCAAAAATACAAAAATTAGCCAGTGATGGTGGCACGCA
CCTGTTGTCCCAGCTACTCAGGAGGCTGAGCTGGGAGGATCTTTTGAGCCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTG
CACTCCAACCTGGAGTGGAAGGAAATTTCACTTCCTGGAATGGAAGAAAGTTCTTCAAAGGAAAATCAAGACACTGCTGTCAAAAAACAC
CAGGGGAGGGATGCTGTCCAGTCACAGCCAACACATCATATAGCAGTGGTAGCAGTAGTAATAGTATTTCCAGAGAGAGAGAGAGAGATT
AGCTCTGAAAAAGAATGGAGAAGAATCAGGTTTCTTGGGGGAGGTAGGTCTCAGGCTAGTTCTTGAATGTACATTCTCAGCAGATGGTGA
GAAGACAAGTGTGGTGTGGGACATTAATGATGAGGGATAGGTAGAAAAGATGGGAAGGGGGTCAGCTTGTAGATAACCTAGACTAGCAGG
TGTATGACTTCTAGTCTCTGAACTGGAGCCATCTGAGATCAGTTTGAGATATGGTGTCTTATAAATGTATTGAGAGAGGTTGAGGAGTTG
TCTATAGAATGGAATGGAGTGAGGTCAGAGATCAGTGGCAAGGAAGACCACATAAAGGTTTTTGCACAAACTTGCCTTGATGGCAAGTCC
TCAAAAGTACAATTATCAAGCTTTCTGTTTAAACATGCATAAGTCAGTAAATATAAACATTAAAATTTGCCCAAGACTCTTAACTCAGTT
GTATTTCATAATTAAAGTGTACATTAAAAAGCCAAACTAGTCATGAAAGTATTACATACAGCAAGGGCAGTTTAGATAAGTTAATGTTGC
TATGGGAACCCCAGCAGATCTCCTTGTGTCTCCGTTTAAAAATCATGGCCCAAGGTGGTTTCAAAAACAACAGAAGGTAAAATTATTCTC
ACATTCTCACACATGTAAATTGTACTGTCTCTCTCAGTTCTAAATAGCGGATTCAAGCCAGCCTCTTGACTGGCACAGTAAAATTCGGCT
TCGTGTCTTTCTATAATGTATTACAGCATGTGAGTTAACCTTTAGAAGCTTCAAAAATACATCAACCAAATTTGGACTGTGAGACACAAA
CTGGTCTCTTTTGGGCTCTGTCCAGCATAGCCTTCCTATTCCACATGGCTGCGCAGCAGGGCCATTTCCACCAGTGTCTTCTGCTTGCCT
GGTCAGTCTTTCTGTCTCTTAACCTACCTACAACAACTTCCTTCTCGGGGTTTGCTGCTAGATAGAAATGTAGATTTTGGCACAGAAAGA
AAAGGGAAAGACCTATTTGGAATTTTGTCTATAGATGTTAAGAAATCATGAAGCGTTGCAAATGTAACTGCTTGGGTATTAGTTTAAAAT
ATTTGATAACTGCATGAAATTCTAATTTACCCCTCACATCCATAAAGCTAGGACCAGTTGGTTAGGCAGAGTTTGATATTTAAAAATTCA
TCTTCTGAGAGAGCTGAATTTCAAAAGGACCATTTTCTTTCCAGGAGTAAAAGGTATATTCTTTCATCTTCTTACAGTACAGAAACAATG
GAATATATTGTTTAAATGCACCCTTCATTTTTTTCTCCATTTCTAAAAATTCACTTTTGAGCATCGTCCAAATGTAAAAATTCTCACACA
TGAGGAACTGTTTCCGAAGGTTGTGAGAAAGTCAAGATAACAGTTTCTATTATTAAAAGTTTTGCATTCGGTATGACACATTTGCCTGTA
TTGAAACACCCATTTAACATTGACTTCTGAGAACTTATTTGCTTTGCCTCTCTCGATTCCATATGCTTTGTCTACAAATTGTGAACACGT
CCCGGTTTCTACCCGTGTGTGATTCTAAGTCGTTGCTGTACTCTAGCTTGTACGTGAAAATTCACCCATATGCAGATAGCTGCCCTCTTG
GAGGCAAAACTTAAAGCTATCAGAACCATCTGGATTGTTAAACCCCAAAACTTCCAACTCATCAAAGTCCTGAAGCCTGAATAGATCACA
CATTGTTACTTCTAATTGGTTTTGATGTTTGTTATGCTCCTCACAAGTGCAGATAACTTCACATTTGCATCACTAATCGACCTCTTTCAA
AGCCTCTGCTCCTCCTGCTTCCTGCCTCTGTTAGTCATCAGGAGACTTAGTGTTGGCGTGGGTATTTTCCCCGCTTGTGAAAGTGCATTG
TCAATTCTAGAGCATTAAATATATGTGAGGTATTGTTATTAATCTACAAGGCAGTACACACAGTATTCCAGCAACAGTGACTTTTTCAAA
GGTTTTATGAGACATTGTAAGAAAGACAGTATCTTTCCATGGAAAAAAGTGTTGCCTCAGAGTCAAACAGGAAGCATGGGTCCTAGTTCC
TATTGAACTGCTTAGCTACTCTTAATTTAGCTCTGAATGCTAGATTTTGTGTATACTATACACATTATTTAATCCTCAAACTCCTAGGAA
TTCATTTTGATGATAACCATTTACAGAAGAGATGTTGGGTAACTTGCTCAGGATACCACATCTAGTAAGTAGCAGAGTCACAACTCGGAC
CCAGAACTCTCTGATTCCAAAACCTCTACTTGCTGCTCTTGTAATGGATGGGCCCAAATGCTGCTGGGAAAGGCACCAGGGAAGAAAGAG
CTTTCTGAGTCAAGCAGAAAACGATAGCAGTGGAGAGGAGTTTGTTTCAGACGACCTTCAAGGTTATGGCTCATTCTAGATCCAATCATT
CTAGCAAATAAGTAGGTTACACTTGTCCACAATTACAAATTGGAAAAGAAGAGAAGGAAAGGAACTGAGAGGAATGACAAAGCAAAAAGC
TTTCAATCAGTTCTTTTCAGCATTCTGCTTCTGCCTAGTTCTGCACTCGCCCCACCCCCTCAGGCTTCAGCCTTCCACTTGGCATCCCTC
CTCGCAGAGCACTCTCACTTGCATACTCCTCGCTTAAAGAAAAAAAGCATTCTGTACTGCAGTGGGGAAAAAAAACCCTTAAAATGTCTT
CAAAAGGATTCAGCTCTAGGGTAATGTAAAATATGTGAAATCAGGAGGTGTCCATAATAAAATATGAGTGAAAACATCGTTATTTAAAAC
ATTGTATGTACATTAATGCCACATTAATACCAATTCAGGCATGAAATGTTGAGCATTTCTTGGAATACGGTTTCTTGGAATATGGTTGGG
GATTTGAGAGGCGCAAAGGTACCCGCAAGATGGCTTTGGTGTAGTTATAAATATAAATAGAAGTAAAATAACAGTTGCATCTTCATTTAT
AATGAATCTATATTGTGGCCTCAAAGCTACAGAGAAAAGTGGATGCCAAAATCTGTCTTTCATTAACATATGTCTTAAATGACAAGGAAG
AGGTGTTGAAGATAAAATTACTTTTTCCTATGAGTATGAATCAGCAACATGCAGTAACAAGCAAGTAATAATAGTTCTGCGTGTGAGTGC
CTACAGAGGGTAAGAAAAATAGCATCAGATTGAAAAAGCAAGTGCACCTGCAGAAGGGACCCAGGAGGCTGCAGAGCACAGCTCCCTTGA
GCATCATCTCAAAGTGTCTCAGAGCACAGTGACCCTAATTCTGGCAAGTCAGGTTGGCATGAGATGGATGGAGCACACTGAAATCTCCAG
ATGGTCAGACAGCCCACCCTCAGCTGCCCCTGGAGCTCGGCAAAGGCAAGCTACAAGGCACTGCTACTTGGCCAAGAGTTTAAAACAACA
GCTTCTGATTCTACAGTGTCTGTGGTTTCACAACCACTTAACCTTAAGTAAGGAACAGCTAGAGTTAGCTGAATGAATAAATACACGTTA
ACGTTACATAAAGAGGGAAAAAAAGCAATACTTGAGCACATAGACTTCAAATAGTGTCCAGCTAGCTGTGTCCTTGGCATCCCAGTGATC
TGGGTCTTTATCTTTGATTTTCTCCAGCAGGTAGGCACTGAGTAGATCCAGGGCCCAGGGCGGGAAATGCTTCTGTATCAGATGTTACCT

>96075_96075_1_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000392415_METTL8_chr2_172217023_ENST00000375258_length(amino acids)=473AA_BP=142
MSWPRAGGRVHPQGEGRCGERARERAGTARARRASAARAPPPGKQRARASPPSFPRDNFTKMSSDRQRSDDESPSTSSGSSDADQRDPAA
PEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCRDHMQWSKEEEAAARKKVKENSAVRVLLEEQVKYEREA
SKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSN
LDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYP
FPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKAS

--------------------------------------------------------------
>96075_96075_2_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000410062_METTL8_chr2_172217023_ENST00000375258_length(transcript)=8482nt_BP=638nt
GAACTTGCTGACTGCGCGGCCGGGAGGAGCCGAGCCGGGCGGCGGCGGCGGGAGGCTACAGCGCGCGGGGGTCTCCCGCGTCCCCTCCGC
CTCGCCGGGAGCTCGCGCCCTCGCCCAGCCGAGCTCCCACCCCCGCTTTTTTCCGAAGGCGCTGGGCGGCGCCACCCTCCGGCCGGAGCC
CGGCACTGCACAACCCCCTCCGACTTTCAATGTTCCACACTCCCCGGCCAGAGCCTCCTCGGCTTCTTTTTTTCCCTCCCCCCCCTTCCC
CCCCCCACAGCTGCCTCCATTTCCTTAAGGAAGGGTTTTTTTCTCTCTCCCTCCCCCACACCGTAGCGGCGCGCGAGCGGGCCGGGCGGG
CGGCCGAGTTTTCCAAGAGATAACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTGGCAGT
TCAGATGCGGACCAGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCCACCCAGCAGAAGAAAAACACC
AAACTCTCTAGCAAAACCACTGCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCT
AATTGCAGGGATCACATGCAGTGGTCTAAGGAAGAAGAAGCAGCAGCCAGAAAAAAAGTAAAAGAAAACTCAGCTGTGCGAGTCCTTCTG
GAAGAGCAAGTTAAGTATGAGAGAGAAGCTAGTAAATACTGGGACACATTTTACAAGATTCATAAGAATAAGTTTTTCAAGGATCGTAAT
TGGCTGTTGAGGGAATTTCCTGAAATTCTTCCAGTTGATCAAAAACCTGAAGAGAAGGCGAGAGAATCATCATGGGATCATGTAAAAACT
AGTGCTACAAATCGTTTCTCAAGAATGCACTGTCCTACTGTGCCTGATGAAAAAAATCATTATGAGAAAAGTTCTGGTTCTTCAGAAGGT
CAAAGCAAAACAGAATCTGATTTTTCCAACCTAGACTCTGAAAAACACAAAAAAGGACCTATGGAGACTGGATTGTTTCCTGGTAGCAAT
GCCACTTTCAGGATACTAGAGGTTGGTTGTGGAGCTGGAAATAGTGTGTTTCCAATTTTGAACACTTTGGAGAACTCTCCGGAGTCCTTT
CTGTATTGTTGTGATTTTGCTTCTGGAGCTGTGGAGCTCGTAAAGTCACACTCGTCCTACAGAGCAACCCAGTGTTTTGCCTTTGTTCAT
GATGTATGTGATGATGGCTTACCTTACCCTTTTCCAGATGGGATCCTGGATGTCATTCTCCTTGTCTTTGTGCTCTCTTCTATTCATCCT
GACAGGATGCAAGGTGTTGTAAACCGACTGTCCAAGTTACTGAAACCTGGGGGAATGCTGTTATTTCGAGACTATGGAAGATATGATAAG
ACTCAGCTTCGTTTTAAAAAGGGACATTGTTTATCTGAAAATTTTTATGTTCGAGGAGATGGTACCAGAGCATATTTCTTTACAAAAGGG
GAAGTCCACAGTATGTTCTGCAAAGCCAGTTTAGATGAAAAGCAAAATCTGGTTGATCGCCGCTTACAAGTTAATAGGAAAAAACAAGTG
AAAATGCACTGAGTGTGGATTCAAGGCAAATTCCAGAAACCATTGCACCAGACTCAGAATAGCTCCAATATGGTATCTACACTCCTTTCA
CAAGACTGAACTTTGTAACATGTTAAGGTACAAAGCCAGAGGACTGTGCTATTCAAGGACTACTGTAAGTCTATTGTTTCTCAAAAGACA
ATGAGAAAAAAAGAAGAGAATTTGTATTTCCTGCCGTTTTGTCATAGGTGAGCTCCTTTGTGCATTTTAAGCACATGTAAGTGGTTCAGC
ACAGTATGCCTTTTTCTGTGCTTTGAAAACTTGATATGCTCAAGCTTGTTTGAATTTATTACATCTAACCATTTTGCTTGTTCCTTGATT
TTTATAAGCATTCAATTAAGTTAGTATTATGTCAAGTAATTTTGAGAAAATGTAACTTGACATTTTTTGCAAGTAAAAAAAATTGTTTAT
TTGTTTAGGCTTAGTAAACCAGTTCCCAAACACAGTCAGACTCTTCCCATTGTCATCTGATTGCAGAGAGAAAGCACACCTTATTTCCAG
GGAAAGCTACAACAAGCCCAAGGTCAAAGTGTATTATTTTTTGTCTTGTTGTTGTCTATTTTCTCCCAATTTTTTTTTGAAATTCAGAGG
CTCATATCTGAAATAGAATTTTAGTTCCTCTTTCCTTTCCTAAAATTGGGGAAGTACAGCCCATGCTGACATTATTTTCAGGCTATTCTT
AGATATACAAGTTGTTAGGCCAGGTGCAATGGCTCGCACCTGTAATCCCAGCACTTTGGGGGGCTGAGGCAGGCAGATCGGTTGAGCTCA
GGAGTTCAAGACCAGCCTGGACAACATGGCAAAACCCTGTCTCTCCCAAGAATACAAAAATTAGCCAGGCATGGTGGCACACACCTGTGG
TCCCAGCTACTCAGGAGACTGAGGTGGGAGGATCGCTTGAGCCTCGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTACCACTGCGCTCCA
AACTGGGTGACATGGTGAGACCTTGTCTCCAAAAAAAAAAAAAAAAAAAAAAAAGGTATGTAAGCTGACAAGCTCTTGTATCAAGGGCTT
TTGAACCAGAGCAACTTCATCTTGAATAGGGACTGTGTAAAATGAAGCTGAGACCTACTAGGCTGCAATCCCAGGAGGTTAAGACATTCT
TAGTCACAGGATGAGATAGGAAGTCAGTACAAGATACAGGTCATACAGACCTTGCTGATAAAACAGGTTGCAGTGAAGAAGCCGGCCAAA
TGCCACCAAAACCAAGATGGCAATGAGAGTGTCCTCTGGCTGTCCTCACTGCTACACTCCCACCAGTGCCATGATAGTTTACAAATGCCA
TGGCAACATCAGGAAGTTACCCATATGGTCTACAAAGGGGAGGCCTGAATAATCCACCCCTTGTGTAGCATATAATCAAGAAATAACCTT
AAAAATGGGCAACCAGTAGCCCTTGGGGCTGCTCTGCCTATGGAGTAGCCATTCTTTATGTTTTACTTTTTTTTTTTTTTTTTTTTTGAG
ATGGAGTCTTGCTCTGGCACCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCCAGCTCCACCTCCCGGGTTCACGCCATTCTCT
TGCTTCAGCCTCCTGAGTAGCTGGGACTACAAGCACCCACCACCATGCCCAGCTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGACGGG
GTTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGA
GCCACCGCGCCCAGCCTATTCTTTACTTAAACTTGTTTTCACTTTGCTGTATGGACTCAATTCTTTCTTGCACAAGATCCAAGAATCCTC
TCTTGGCGTCTGGATCCAGACCCTTTCTGGTATCAGTGGTAAGCTCTGTTTAAGACAACTGTCATACCCAAGAGAATTCTTAAATTGTGG
CAGTTAAAAATGTATTTATCCCCTCGAGGGCCGGGCGCAGTCGCTCAAGCCCGTAATCCCAGCACTTTGGGAGGCCGAGGAGGCGGATCA
TGAGGTCAGGAGTTCAAGACCAGCCTGACCAACACTGTGAAACCCTGTCTCTACTAAAAATACAAAAAAAATTAGCCAGGCGTGGTGGTG
GGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATGACACC
ACTGCCCTCCAGCCTGGGTGACAGTTGTTAGACTGCGTATCAAAAAAAAAAAAAAAAATTTATTTACTCCCTTGCTTCAAAAAGGACATA
AGTTGGCTTGCAAATCACATTTTGTAGAAATGAAGTTTTTAAGATTAGTCTCATACTCATTACATAATATTTATTGACTACTTACATATT
GAGTGCTAAATTCAGTGGAATAATATGAACAATAAAGACCCAGCCTTGTTTATGCTCTTCAGGGAGCATAAATAGAGTACAGCTGGCAAA
ACAAAATGTGCATATCCCAAACCTGTAAATCATGATCTAAGACAATATACAAACACTCAAATAGGGAACTTACCAGCTAGCAGACTTTGA
TTATGAACCACAGAACCTAGAATAAATAAATACTCTCTTGAAAGAACCATCATTGGAATAATTAAGTTCCAACTGTTTTTTCTTTCTGAA
TTCACTTAAAATCCAATTTCTAGAAGAATATCATTGGTCCAGCTTTAGTCATTGGTTCATCTCTTAACAGGCTGGGGCAGGGCAGCTTAA
TTGATGATGCCACCAGAATGGGCAACATGGGAAAAACCCTATCTCTACCAAAAATACAAAAATTAGCCAGTGATGGTGGCACGCACCTGT
TGTCCCAGCTACTCAGGAGGCTGAGCTGGGAGGATCTTTTGAGCCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTC
CAACCTGGAGTGGAAGGAAATTTCACTTCCTGGAATGGAAGAAAGTTCTTCAAAGGAAAATCAAGACACTGCTGTCAAAAAACACCAGGG
GAGGGATGCTGTCCAGTCACAGCCAACACATCATATAGCAGTGGTAGCAGTAGTAATAGTATTTCCAGAGAGAGAGAGAGAGATTAGCTC
TGAAAAAGAATGGAGAAGAATCAGGTTTCTTGGGGGAGGTAGGTCTCAGGCTAGTTCTTGAATGTACATTCTCAGCAGATGGTGAGAAGA
CAAGTGTGGTGTGGGACATTAATGATGAGGGATAGGTAGAAAAGATGGGAAGGGGGTCAGCTTGTAGATAACCTAGACTAGCAGGTGTAT
GACTTCTAGTCTCTGAACTGGAGCCATCTGAGATCAGTTTGAGATATGGTGTCTTATAAATGTATTGAGAGAGGTTGAGGAGTTGTCTAT
AGAATGGAATGGAGTGAGGTCAGAGATCAGTGGCAAGGAAGACCACATAAAGGTTTTTGCACAAACTTGCCTTGATGGCAAGTCCTCAAA
AGTACAATTATCAAGCTTTCTGTTTAAACATGCATAAGTCAGTAAATATAAACATTAAAATTTGCCCAAGACTCTTAACTCAGTTGTATT
TCATAATTAAAGTGTACATTAAAAAGCCAAACTAGTCATGAAAGTATTACATACAGCAAGGGCAGTTTAGATAAGTTAATGTTGCTATGG
GAACCCCAGCAGATCTCCTTGTGTCTCCGTTTAAAAATCATGGCCCAAGGTGGTTTCAAAAACAACAGAAGGTAAAATTATTCTCACATT
CTCACACATGTAAATTGTACTGTCTCTCTCAGTTCTAAATAGCGGATTCAAGCCAGCCTCTTGACTGGCACAGTAAAATTCGGCTTCGTG
TCTTTCTATAATGTATTACAGCATGTGAGTTAACCTTTAGAAGCTTCAAAAATACATCAACCAAATTTGGACTGTGAGACACAAACTGGT
CTCTTTTGGGCTCTGTCCAGCATAGCCTTCCTATTCCACATGGCTGCGCAGCAGGGCCATTTCCACCAGTGTCTTCTGCTTGCCTGGTCA
GTCTTTCTGTCTCTTAACCTACCTACAACAACTTCCTTCTCGGGGTTTGCTGCTAGATAGAAATGTAGATTTTGGCACAGAAAGAAAAGG
GAAAGACCTATTTGGAATTTTGTCTATAGATGTTAAGAAATCATGAAGCGTTGCAAATGTAACTGCTTGGGTATTAGTTTAAAATATTTG
ATAACTGCATGAAATTCTAATTTACCCCTCACATCCATAAAGCTAGGACCAGTTGGTTAGGCAGAGTTTGATATTTAAAAATTCATCTTC
TGAGAGAGCTGAATTTCAAAAGGACCATTTTCTTTCCAGGAGTAAAAGGTATATTCTTTCATCTTCTTACAGTACAGAAACAATGGAATA
TATTGTTTAAATGCACCCTTCATTTTTTTCTCCATTTCTAAAAATTCACTTTTGAGCATCGTCCAAATGTAAAAATTCTCACACATGAGG
AACTGTTTCCGAAGGTTGTGAGAAAGTCAAGATAACAGTTTCTATTATTAAAAGTTTTGCATTCGGTATGACACATTTGCCTGTATTGAA
ACACCCATTTAACATTGACTTCTGAGAACTTATTTGCTTTGCCTCTCTCGATTCCATATGCTTTGTCTACAAATTGTGAACACGTCCCGG
TTTCTACCCGTGTGTGATTCTAAGTCGTTGCTGTACTCTAGCTTGTACGTGAAAATTCACCCATATGCAGATAGCTGCCCTCTTGGAGGC
AAAACTTAAAGCTATCAGAACCATCTGGATTGTTAAACCCCAAAACTTCCAACTCATCAAAGTCCTGAAGCCTGAATAGATCACACATTG
TTACTTCTAATTGGTTTTGATGTTTGTTATGCTCCTCACAAGTGCAGATAACTTCACATTTGCATCACTAATCGACCTCTTTCAAAGCCT
CTGCTCCTCCTGCTTCCTGCCTCTGTTAGTCATCAGGAGACTTAGTGTTGGCGTGGGTATTTTCCCCGCTTGTGAAAGTGCATTGTCAAT
TCTAGAGCATTAAATATATGTGAGGTATTGTTATTAATCTACAAGGCAGTACACACAGTATTCCAGCAACAGTGACTTTTTCAAAGGTTT
TATGAGACATTGTAAGAAAGACAGTATCTTTCCATGGAAAAAAGTGTTGCCTCAGAGTCAAACAGGAAGCATGGGTCCTAGTTCCTATTG
AACTGCTTAGCTACTCTTAATTTAGCTCTGAATGCTAGATTTTGTGTATACTATACACATTATTTAATCCTCAAACTCCTAGGAATTCAT
TTTGATGATAACCATTTACAGAAGAGATGTTGGGTAACTTGCTCAGGATACCACATCTAGTAAGTAGCAGAGTCACAACTCGGACCCAGA
ACTCTCTGATTCCAAAACCTCTACTTGCTGCTCTTGTAATGGATGGGCCCAAATGCTGCTGGGAAAGGCACCAGGGAAGAAAGAGCTTTC
TGAGTCAAGCAGAAAACGATAGCAGTGGAGAGGAGTTTGTTTCAGACGACCTTCAAGGTTATGGCTCATTCTAGATCCAATCATTCTAGC
AAATAAGTAGGTTACACTTGTCCACAATTACAAATTGGAAAAGAAGAGAAGGAAAGGAACTGAGAGGAATGACAAAGCAAAAAGCTTTCA
ATCAGTTCTTTTCAGCATTCTGCTTCTGCCTAGTTCTGCACTCGCCCCACCCCCTCAGGCTTCAGCCTTCCACTTGGCATCCCTCCTCGC
AGAGCACTCTCACTTGCATACTCCTCGCTTAAAGAAAAAAAGCATTCTGTACTGCAGTGGGGAAAAAAAACCCTTAAAATGTCTTCAAAA
GGATTCAGCTCTAGGGTAATGTAAAATATGTGAAATCAGGAGGTGTCCATAATAAAATATGAGTGAAAACATCGTTATTTAAAACATTGT
ATGTACATTAATGCCACATTAATACCAATTCAGGCATGAAATGTTGAGCATTTCTTGGAATACGGTTTCTTGGAATATGGTTGGGGATTT
GAGAGGCGCAAAGGTACCCGCAAGATGGCTTTGGTGTAGTTATAAATATAAATAGAAGTAAAATAACAGTTGCATCTTCATTTATAATGA
ATCTATATTGTGGCCTCAAAGCTACAGAGAAAAGTGGATGCCAAAATCTGTCTTTCATTAACATATGTCTTAAATGACAAGGAAGAGGTG
TTGAAGATAAAATTACTTTTTCCTATGAGTATGAATCAGCAACATGCAGTAACAAGCAAGTAATAATAGTTCTGCGTGTGAGTGCCTACA
GAGGGTAAGAAAAATAGCATCAGATTGAAAAAGCAAGTGCACCTGCAGAAGGGACCCAGGAGGCTGCAGAGCACAGCTCCCTTGAGCATC
ATCTCAAAGTGTCTCAGAGCACAGTGACCCTAATTCTGGCAAGTCAGGTTGGCATGAGATGGATGGAGCACACTGAAATCTCCAGATGGT
CAGACAGCCCACCCTCAGCTGCCCCTGGAGCTCGGCAAAGGCAAGCTACAAGGCACTGCTACTTGGCCAAGAGTTTAAAACAACAGCTTC
TGATTCTACAGTGTCTGTGGTTTCACAACCACTTAACCTTAAGTAAGGAACAGCTAGAGTTAGCTGAATGAATAAATACACGTTAACGTT
ACATAAAGAGGGAAAAAAAGCAATACTTGAGCACATAGACTTCAAATAGTGTCCAGCTAGCTGTGTCCTTGGCATCCCAGTGATCTGGGT
CTTTATCTTTGATTTTCTCCAGCAGGTAGGCACTGAGTAGATCCAGGGCCCAGGGCGGGAAATGCTTCTGTATCAGATGTTACCTATCAA

>96075_96075_2_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000410062_METTL8_chr2_172217023_ENST00000375258_length(amino acids)=412AA_BP=81
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCRDHMQWSKE
EEAAARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSRMHC
PTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAV
ELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCL

--------------------------------------------------------------
>96075_96075_3_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000602475_METTL8_chr2_172217023_ENST00000375258_length(transcript)=8281nt_BP=437nt
GACTTTCAATGTTCCACACTCCCCGGCCAGAGCCTCCTCGGCTTCTTTTTTTCCCTCCCCCCCCTTCCCCCCCCCACAGCTGCCTCCATT
TCCTTAAGGAAGGGTTTTTTTCTCTCTCCCTCCCCCACACCGTAGCGGCGCGCGAGCGGGCCGGGCGGGCGGCCGAGTTTTCCAAGAGAT
AACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTGGCAGTTCAGATGCGGACCAGCGAGAC
CCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCCACCCAGCAGAAGAAAAACACCAAACTCTCTAGCAAAACCACT
GCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCTAATTGCAGGGATCACATGCAG
TGGTCTAAGGAAGAAGAAGCAGCAGCCAGAAAAAAAGTAAAAGAAAACTCAGCTGTGCGAGTCCTTCTGGAAGAGCAAGTTAAGTATGAG
AGAGAAGCTAGTAAATACTGGGACACATTTTACAAGATTCATAAGAATAAGTTTTTCAAGGATCGTAATTGGCTGTTGAGGGAATTTCCT
GAAATTCTTCCAGTTGATCAAAAACCTGAAGAGAAGGCGAGAGAATCATCATGGGATCATGTAAAAACTAGTGCTACAAATCGTTTCTCA
AGAATGCACTGTCCTACTGTGCCTGATGAAAAAAATCATTATGAGAAAAGTTCTGGTTCTTCAGAAGGTCAAAGCAAAACAGAATCTGAT
TTTTCCAACCTAGACTCTGAAAAACACAAAAAAGGACCTATGGAGACTGGATTGTTTCCTGGTAGCAATGCCACTTTCAGGATACTAGAG
GTTGGTTGTGGAGCTGGAAATAGTGTGTTTCCAATTTTGAACACTTTGGAGAACTCTCCGGAGTCCTTTCTGTATTGTTGTGATTTTGCT
TCTGGAGCTGTGGAGCTCGTAAAGTCACACTCGTCCTACAGAGCAACCCAGTGTTTTGCCTTTGTTCATGATGTATGTGATGATGGCTTA
CCTTACCCTTTTCCAGATGGGATCCTGGATGTCATTCTCCTTGTCTTTGTGCTCTCTTCTATTCATCCTGACAGGATGCAAGGTGTTGTA
AACCGACTGTCCAAGTTACTGAAACCTGGGGGAATGCTGTTATTTCGAGACTATGGAAGATATGATAAGACTCAGCTTCGTTTTAAAAAG
GGACATTGTTTATCTGAAAATTTTTATGTTCGAGGAGATGGTACCAGAGCATATTTCTTTACAAAAGGGGAAGTCCACAGTATGTTCTGC
AAAGCCAGTTTAGATGAAAAGCAAAATCTGGTTGATCGCCGCTTACAAGTTAATAGGAAAAAACAAGTGAAAATGCACTGAGTGTGGATT
CAAGGCAAATTCCAGAAACCATTGCACCAGACTCAGAATAGCTCCAATATGGTATCTACACTCCTTTCACAAGACTGAACTTTGTAACAT
GTTAAGGTACAAAGCCAGAGGACTGTGCTATTCAAGGACTACTGTAAGTCTATTGTTTCTCAAAAGACAATGAGAAAAAAAGAAGAGAAT
TTGTATTTCCTGCCGTTTTGTCATAGGTGAGCTCCTTTGTGCATTTTAAGCACATGTAAGTGGTTCAGCACAGTATGCCTTTTTCTGTGC
TTTGAAAACTTGATATGCTCAAGCTTGTTTGAATTTATTACATCTAACCATTTTGCTTGTTCCTTGATTTTTATAAGCATTCAATTAAGT
TAGTATTATGTCAAGTAATTTTGAGAAAATGTAACTTGACATTTTTTGCAAGTAAAAAAAATTGTTTATTTGTTTAGGCTTAGTAAACCA
GTTCCCAAACACAGTCAGACTCTTCCCATTGTCATCTGATTGCAGAGAGAAAGCACACCTTATTTCCAGGGAAAGCTACAACAAGCCCAA
GGTCAAAGTGTATTATTTTTTGTCTTGTTGTTGTCTATTTTCTCCCAATTTTTTTTTGAAATTCAGAGGCTCATATCTGAAATAGAATTT
TAGTTCCTCTTTCCTTTCCTAAAATTGGGGAAGTACAGCCCATGCTGACATTATTTTCAGGCTATTCTTAGATATACAAGTTGTTAGGCC
AGGTGCAATGGCTCGCACCTGTAATCCCAGCACTTTGGGGGGCTGAGGCAGGCAGATCGGTTGAGCTCAGGAGTTCAAGACCAGCCTGGA
CAACATGGCAAAACCCTGTCTCTCCCAAGAATACAAAAATTAGCCAGGCATGGTGGCACACACCTGTGGTCCCAGCTACTCAGGAGACTG
AGGTGGGAGGATCGCTTGAGCCTCGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTACCACTGCGCTCCAAACTGGGTGACATGGTGAGAC
CTTGTCTCCAAAAAAAAAAAAAAAAAAAAAAAAGGTATGTAAGCTGACAAGCTCTTGTATCAAGGGCTTTTGAACCAGAGCAACTTCATC
TTGAATAGGGACTGTGTAAAATGAAGCTGAGACCTACTAGGCTGCAATCCCAGGAGGTTAAGACATTCTTAGTCACAGGATGAGATAGGA
AGTCAGTACAAGATACAGGTCATACAGACCTTGCTGATAAAACAGGTTGCAGTGAAGAAGCCGGCCAAATGCCACCAAAACCAAGATGGC
AATGAGAGTGTCCTCTGGCTGTCCTCACTGCTACACTCCCACCAGTGCCATGATAGTTTACAAATGCCATGGCAACATCAGGAAGTTACC
CATATGGTCTACAAAGGGGAGGCCTGAATAATCCACCCCTTGTGTAGCATATAATCAAGAAATAACCTTAAAAATGGGCAACCAGTAGCC
CTTGGGGCTGCTCTGCCTATGGAGTAGCCATTCTTTATGTTTTACTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGGCACC
CAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCCAGCTCCACCTCCCGGGTTCACGCCATTCTCTTGCTTCAGCCTCCTGAGTAGC
TGGGACTACAAGCACCCACCACCATGCCCAGCTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGA
TGGTCTCAATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCCAGCCTATTC
TTTACTTAAACTTGTTTTCACTTTGCTGTATGGACTCAATTCTTTCTTGCACAAGATCCAAGAATCCTCTCTTGGCGTCTGGATCCAGAC
CCTTTCTGGTATCAGTGGTAAGCTCTGTTTAAGACAACTGTCATACCCAAGAGAATTCTTAAATTGTGGCAGTTAAAAATGTATTTATCC
CCTCGAGGGCCGGGCGCAGTCGCTCAAGCCCGTAATCCCAGCACTTTGGGAGGCCGAGGAGGCGGATCATGAGGTCAGGAGTTCAAGACC
AGCCTGACCAACACTGTGAAACCCTGTCTCTACTAAAAATACAAAAAAAATTAGCCAGGCGTGGTGGTGGGCACCTGTAATCCCAGCTAC
TCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATGACACCACTGCCCTCCAGCCTGGGTGA
CAGTTGTTAGACTGCGTATCAAAAAAAAAAAAAAAAATTTATTTACTCCCTTGCTTCAAAAAGGACATAAGTTGGCTTGCAAATCACATT
TTGTAGAAATGAAGTTTTTAAGATTAGTCTCATACTCATTACATAATATTTATTGACTACTTACATATTGAGTGCTAAATTCAGTGGAAT
AATATGAACAATAAAGACCCAGCCTTGTTTATGCTCTTCAGGGAGCATAAATAGAGTACAGCTGGCAAAACAAAATGTGCATATCCCAAA
CCTGTAAATCATGATCTAAGACAATATACAAACACTCAAATAGGGAACTTACCAGCTAGCAGACTTTGATTATGAACCACAGAACCTAGA
ATAAATAAATACTCTCTTGAAAGAACCATCATTGGAATAATTAAGTTCCAACTGTTTTTTCTTTCTGAATTCACTTAAAATCCAATTTCT
AGAAGAATATCATTGGTCCAGCTTTAGTCATTGGTTCATCTCTTAACAGGCTGGGGCAGGGCAGCTTAATTGATGATGCCACCAGAATGG
GCAACATGGGAAAAACCCTATCTCTACCAAAAATACAAAAATTAGCCAGTGATGGTGGCACGCACCTGTTGTCCCAGCTACTCAGGAGGC
TGAGCTGGGAGGATCTTTTGAGCCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAACCTGGAGTGGAAGGAAAT
TTCACTTCCTGGAATGGAAGAAAGTTCTTCAAAGGAAAATCAAGACACTGCTGTCAAAAAACACCAGGGGAGGGATGCTGTCCAGTCACA
GCCAACACATCATATAGCAGTGGTAGCAGTAGTAATAGTATTTCCAGAGAGAGAGAGAGAGATTAGCTCTGAAAAAGAATGGAGAAGAAT
CAGGTTTCTTGGGGGAGGTAGGTCTCAGGCTAGTTCTTGAATGTACATTCTCAGCAGATGGTGAGAAGACAAGTGTGGTGTGGGACATTA
ATGATGAGGGATAGGTAGAAAAGATGGGAAGGGGGTCAGCTTGTAGATAACCTAGACTAGCAGGTGTATGACTTCTAGTCTCTGAACTGG
AGCCATCTGAGATCAGTTTGAGATATGGTGTCTTATAAATGTATTGAGAGAGGTTGAGGAGTTGTCTATAGAATGGAATGGAGTGAGGTC
AGAGATCAGTGGCAAGGAAGACCACATAAAGGTTTTTGCACAAACTTGCCTTGATGGCAAGTCCTCAAAAGTACAATTATCAAGCTTTCT
GTTTAAACATGCATAAGTCAGTAAATATAAACATTAAAATTTGCCCAAGACTCTTAACTCAGTTGTATTTCATAATTAAAGTGTACATTA
AAAAGCCAAACTAGTCATGAAAGTATTACATACAGCAAGGGCAGTTTAGATAAGTTAATGTTGCTATGGGAACCCCAGCAGATCTCCTTG
TGTCTCCGTTTAAAAATCATGGCCCAAGGTGGTTTCAAAAACAACAGAAGGTAAAATTATTCTCACATTCTCACACATGTAAATTGTACT
GTCTCTCTCAGTTCTAAATAGCGGATTCAAGCCAGCCTCTTGACTGGCACAGTAAAATTCGGCTTCGTGTCTTTCTATAATGTATTACAG
CATGTGAGTTAACCTTTAGAAGCTTCAAAAATACATCAACCAAATTTGGACTGTGAGACACAAACTGGTCTCTTTTGGGCTCTGTCCAGC
ATAGCCTTCCTATTCCACATGGCTGCGCAGCAGGGCCATTTCCACCAGTGTCTTCTGCTTGCCTGGTCAGTCTTTCTGTCTCTTAACCTA
CCTACAACAACTTCCTTCTCGGGGTTTGCTGCTAGATAGAAATGTAGATTTTGGCACAGAAAGAAAAGGGAAAGACCTATTTGGAATTTT
GTCTATAGATGTTAAGAAATCATGAAGCGTTGCAAATGTAACTGCTTGGGTATTAGTTTAAAATATTTGATAACTGCATGAAATTCTAAT
TTACCCCTCACATCCATAAAGCTAGGACCAGTTGGTTAGGCAGAGTTTGATATTTAAAAATTCATCTTCTGAGAGAGCTGAATTTCAAAA
GGACCATTTTCTTTCCAGGAGTAAAAGGTATATTCTTTCATCTTCTTACAGTACAGAAACAATGGAATATATTGTTTAAATGCACCCTTC
ATTTTTTTCTCCATTTCTAAAAATTCACTTTTGAGCATCGTCCAAATGTAAAAATTCTCACACATGAGGAACTGTTTCCGAAGGTTGTGA
GAAAGTCAAGATAACAGTTTCTATTATTAAAAGTTTTGCATTCGGTATGACACATTTGCCTGTATTGAAACACCCATTTAACATTGACTT
CTGAGAACTTATTTGCTTTGCCTCTCTCGATTCCATATGCTTTGTCTACAAATTGTGAACACGTCCCGGTTTCTACCCGTGTGTGATTCT
AAGTCGTTGCTGTACTCTAGCTTGTACGTGAAAATTCACCCATATGCAGATAGCTGCCCTCTTGGAGGCAAAACTTAAAGCTATCAGAAC
CATCTGGATTGTTAAACCCCAAAACTTCCAACTCATCAAAGTCCTGAAGCCTGAATAGATCACACATTGTTACTTCTAATTGGTTTTGAT
GTTTGTTATGCTCCTCACAAGTGCAGATAACTTCACATTTGCATCACTAATCGACCTCTTTCAAAGCCTCTGCTCCTCCTGCTTCCTGCC
TCTGTTAGTCATCAGGAGACTTAGTGTTGGCGTGGGTATTTTCCCCGCTTGTGAAAGTGCATTGTCAATTCTAGAGCATTAAATATATGT
GAGGTATTGTTATTAATCTACAAGGCAGTACACACAGTATTCCAGCAACAGTGACTTTTTCAAAGGTTTTATGAGACATTGTAAGAAAGA
CAGTATCTTTCCATGGAAAAAAGTGTTGCCTCAGAGTCAAACAGGAAGCATGGGTCCTAGTTCCTATTGAACTGCTTAGCTACTCTTAAT
TTAGCTCTGAATGCTAGATTTTGTGTATACTATACACATTATTTAATCCTCAAACTCCTAGGAATTCATTTTGATGATAACCATTTACAG
AAGAGATGTTGGGTAACTTGCTCAGGATACCACATCTAGTAAGTAGCAGAGTCACAACTCGGACCCAGAACTCTCTGATTCCAAAACCTC
TACTTGCTGCTCTTGTAATGGATGGGCCCAAATGCTGCTGGGAAAGGCACCAGGGAAGAAAGAGCTTTCTGAGTCAAGCAGAAAACGATA
GCAGTGGAGAGGAGTTTGTTTCAGACGACCTTCAAGGTTATGGCTCATTCTAGATCCAATCATTCTAGCAAATAAGTAGGTTACACTTGT
CCACAATTACAAATTGGAAAAGAAGAGAAGGAAAGGAACTGAGAGGAATGACAAAGCAAAAAGCTTTCAATCAGTTCTTTTCAGCATTCT
GCTTCTGCCTAGTTCTGCACTCGCCCCACCCCCTCAGGCTTCAGCCTTCCACTTGGCATCCCTCCTCGCAGAGCACTCTCACTTGCATAC
TCCTCGCTTAAAGAAAAAAAGCATTCTGTACTGCAGTGGGGAAAAAAAACCCTTAAAATGTCTTCAAAAGGATTCAGCTCTAGGGTAATG
TAAAATATGTGAAATCAGGAGGTGTCCATAATAAAATATGAGTGAAAACATCGTTATTTAAAACATTGTATGTACATTAATGCCACATTA
ATACCAATTCAGGCATGAAATGTTGAGCATTTCTTGGAATACGGTTTCTTGGAATATGGTTGGGGATTTGAGAGGCGCAAAGGTACCCGC
AAGATGGCTTTGGTGTAGTTATAAATATAAATAGAAGTAAAATAACAGTTGCATCTTCATTTATAATGAATCTATATTGTGGCCTCAAAG
CTACAGAGAAAAGTGGATGCCAAAATCTGTCTTTCATTAACATATGTCTTAAATGACAAGGAAGAGGTGTTGAAGATAAAATTACTTTTT
CCTATGAGTATGAATCAGCAACATGCAGTAACAAGCAAGTAATAATAGTTCTGCGTGTGAGTGCCTACAGAGGGTAAGAAAAATAGCATC
AGATTGAAAAAGCAAGTGCACCTGCAGAAGGGACCCAGGAGGCTGCAGAGCACAGCTCCCTTGAGCATCATCTCAAAGTGTCTCAGAGCA
CAGTGACCCTAATTCTGGCAAGTCAGGTTGGCATGAGATGGATGGAGCACACTGAAATCTCCAGATGGTCAGACAGCCCACCCTCAGCTG
CCCCTGGAGCTCGGCAAAGGCAAGCTACAAGGCACTGCTACTTGGCCAAGAGTTTAAAACAACAGCTTCTGATTCTACAGTGTCTGTGGT
TTCACAACCACTTAACCTTAAGTAAGGAACAGCTAGAGTTAGCTGAATGAATAAATACACGTTAACGTTACATAAAGAGGGAAAAAAAGC
AATACTTGAGCACATAGACTTCAAATAGTGTCCAGCTAGCTGTGTCCTTGGCATCCCAGTGATCTGGGTCTTTATCTTTGATTTTCTCCA
GCAGGTAGGCACTGAGTAGATCCAGGGCCCAGGGCGGGAAATGCTTCTGTATCAGATGTTACCTATCAAATAAAATGAGCCTTTGATTGC

>96075_96075_3_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000602475_METTL8_chr2_172217023_ENST00000375258_length(amino acids)=412AA_BP=81
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCRDHMQWSKE
EEAAARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSRMHC
PTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAV
ELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCL

--------------------------------------------------------------
>96075_96075_4_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000602632_METTL8_chr2_172217023_ENST00000375258_length(transcript)=8109nt_BP=265nt
CAAGAGATAACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTGGCAGTTCAGATGCGGACC
AGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCCACCCAGCAGAAGAAAAACACCAAACTCTCTAGCA
AAACCACTGCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCTAATTGCAGGGATC
ACATGCAGTGGTCTAAGGAAGAAGAAGCAGCAGCCAGAAAAAAAGTAAAAGAAAACTCAGCTGTGCGAGTCCTTCTGGAAGAGCAAGTTA
AGTATGAGAGAGAAGCTAGTAAATACTGGGACACATTTTACAAGATTCATAAGAATAAGTTTTTCAAGGATCGTAATTGGCTGTTGAGGG
AATTTCCTGAAATTCTTCCAGTTGATCAAAAACCTGAAGAGAAGGCGAGAGAATCATCATGGGATCATGTAAAAACTAGTGCTACAAATC
GTTTCTCAAGAATGCACTGTCCTACTGTGCCTGATGAAAAAAATCATTATGAGAAAAGTTCTGGTTCTTCAGAAGGTCAAAGCAAAACAG
AATCTGATTTTTCCAACCTAGACTCTGAAAAACACAAAAAAGGACCTATGGAGACTGGATTGTTTCCTGGTAGCAATGCCACTTTCAGGA
TACTAGAGGTTGGTTGTGGAGCTGGAAATAGTGTGTTTCCAATTTTGAACACTTTGGAGAACTCTCCGGAGTCCTTTCTGTATTGTTGTG
ATTTTGCTTCTGGAGCTGTGGAGCTCGTAAAGTCACACTCGTCCTACAGAGCAACCCAGTGTTTTGCCTTTGTTCATGATGTATGTGATG
ATGGCTTACCTTACCCTTTTCCAGATGGGATCCTGGATGTCATTCTCCTTGTCTTTGTGCTCTCTTCTATTCATCCTGACAGGATGCAAG
GTGTTGTAAACCGACTGTCCAAGTTACTGAAACCTGGGGGAATGCTGTTATTTCGAGACTATGGAAGATATGATAAGACTCAGCTTCGTT
TTAAAAAGGGACATTGTTTATCTGAAAATTTTTATGTTCGAGGAGATGGTACCAGAGCATATTTCTTTACAAAAGGGGAAGTCCACAGTA
TGTTCTGCAAAGCCAGTTTAGATGAAAAGCAAAATCTGGTTGATCGCCGCTTACAAGTTAATAGGAAAAAACAAGTGAAAATGCACTGAG
TGTGGATTCAAGGCAAATTCCAGAAACCATTGCACCAGACTCAGAATAGCTCCAATATGGTATCTACACTCCTTTCACAAGACTGAACTT
TGTAACATGTTAAGGTACAAAGCCAGAGGACTGTGCTATTCAAGGACTACTGTAAGTCTATTGTTTCTCAAAAGACAATGAGAAAAAAAG
AAGAGAATTTGTATTTCCTGCCGTTTTGTCATAGGTGAGCTCCTTTGTGCATTTTAAGCACATGTAAGTGGTTCAGCACAGTATGCCTTT
TTCTGTGCTTTGAAAACTTGATATGCTCAAGCTTGTTTGAATTTATTACATCTAACCATTTTGCTTGTTCCTTGATTTTTATAAGCATTC
AATTAAGTTAGTATTATGTCAAGTAATTTTGAGAAAATGTAACTTGACATTTTTTGCAAGTAAAAAAAATTGTTTATTTGTTTAGGCTTA
GTAAACCAGTTCCCAAACACAGTCAGACTCTTCCCATTGTCATCTGATTGCAGAGAGAAAGCACACCTTATTTCCAGGGAAAGCTACAAC
AAGCCCAAGGTCAAAGTGTATTATTTTTTGTCTTGTTGTTGTCTATTTTCTCCCAATTTTTTTTTGAAATTCAGAGGCTCATATCTGAAA
TAGAATTTTAGTTCCTCTTTCCTTTCCTAAAATTGGGGAAGTACAGCCCATGCTGACATTATTTTCAGGCTATTCTTAGATATACAAGTT
GTTAGGCCAGGTGCAATGGCTCGCACCTGTAATCCCAGCACTTTGGGGGGCTGAGGCAGGCAGATCGGTTGAGCTCAGGAGTTCAAGACC
AGCCTGGACAACATGGCAAAACCCTGTCTCTCCCAAGAATACAAAAATTAGCCAGGCATGGTGGCACACACCTGTGGTCCCAGCTACTCA
GGAGACTGAGGTGGGAGGATCGCTTGAGCCTCGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTACCACTGCGCTCCAAACTGGGTGACAT
GGTGAGACCTTGTCTCCAAAAAAAAAAAAAAAAAAAAAAAAGGTATGTAAGCTGACAAGCTCTTGTATCAAGGGCTTTTGAACCAGAGCA
ACTTCATCTTGAATAGGGACTGTGTAAAATGAAGCTGAGACCTACTAGGCTGCAATCCCAGGAGGTTAAGACATTCTTAGTCACAGGATG
AGATAGGAAGTCAGTACAAGATACAGGTCATACAGACCTTGCTGATAAAACAGGTTGCAGTGAAGAAGCCGGCCAAATGCCACCAAAACC
AAGATGGCAATGAGAGTGTCCTCTGGCTGTCCTCACTGCTACACTCCCACCAGTGCCATGATAGTTTACAAATGCCATGGCAACATCAGG
AAGTTACCCATATGGTCTACAAAGGGGAGGCCTGAATAATCCACCCCTTGTGTAGCATATAATCAAGAAATAACCTTAAAAATGGGCAAC
CAGTAGCCCTTGGGGCTGCTCTGCCTATGGAGTAGCCATTCTTTATGTTTTACTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCT
CTGGCACCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCCAGCTCCACCTCCCGGGTTCACGCCATTCTCTTGCTTCAGCCTCC
TGAGTAGCTGGGACTACAAGCACCCACCACCATGCCCAGCTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTT
AGCCAGGATGGTCTCAATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCCA
GCCTATTCTTTACTTAAACTTGTTTTCACTTTGCTGTATGGACTCAATTCTTTCTTGCACAAGATCCAAGAATCCTCTCTTGGCGTCTGG
ATCCAGACCCTTTCTGGTATCAGTGGTAAGCTCTGTTTAAGACAACTGTCATACCCAAGAGAATTCTTAAATTGTGGCAGTTAAAAATGT
ATTTATCCCCTCGAGGGCCGGGCGCAGTCGCTCAAGCCCGTAATCCCAGCACTTTGGGAGGCCGAGGAGGCGGATCATGAGGTCAGGAGT
TCAAGACCAGCCTGACCAACACTGTGAAACCCTGTCTCTACTAAAAATACAAAAAAAATTAGCCAGGCGTGGTGGTGGGCACCTGTAATC
CCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATGACACCACTGCCCTCCAGC
CTGGGTGACAGTTGTTAGACTGCGTATCAAAAAAAAAAAAAAAAATTTATTTACTCCCTTGCTTCAAAAAGGACATAAGTTGGCTTGCAA
ATCACATTTTGTAGAAATGAAGTTTTTAAGATTAGTCTCATACTCATTACATAATATTTATTGACTACTTACATATTGAGTGCTAAATTC
AGTGGAATAATATGAACAATAAAGACCCAGCCTTGTTTATGCTCTTCAGGGAGCATAAATAGAGTACAGCTGGCAAAACAAAATGTGCAT
ATCCCAAACCTGTAAATCATGATCTAAGACAATATACAAACACTCAAATAGGGAACTTACCAGCTAGCAGACTTTGATTATGAACCACAG
AACCTAGAATAAATAAATACTCTCTTGAAAGAACCATCATTGGAATAATTAAGTTCCAACTGTTTTTTCTTTCTGAATTCACTTAAAATC
CAATTTCTAGAAGAATATCATTGGTCCAGCTTTAGTCATTGGTTCATCTCTTAACAGGCTGGGGCAGGGCAGCTTAATTGATGATGCCAC
CAGAATGGGCAACATGGGAAAAACCCTATCTCTACCAAAAATACAAAAATTAGCCAGTGATGGTGGCACGCACCTGTTGTCCCAGCTACT
CAGGAGGCTGAGCTGGGAGGATCTTTTGAGCCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAACCTGGAGTGG
AAGGAAATTTCACTTCCTGGAATGGAAGAAAGTTCTTCAAAGGAAAATCAAGACACTGCTGTCAAAAAACACCAGGGGAGGGATGCTGTC
CAGTCACAGCCAACACATCATATAGCAGTGGTAGCAGTAGTAATAGTATTTCCAGAGAGAGAGAGAGAGATTAGCTCTGAAAAAGAATGG
AGAAGAATCAGGTTTCTTGGGGGAGGTAGGTCTCAGGCTAGTTCTTGAATGTACATTCTCAGCAGATGGTGAGAAGACAAGTGTGGTGTG
GGACATTAATGATGAGGGATAGGTAGAAAAGATGGGAAGGGGGTCAGCTTGTAGATAACCTAGACTAGCAGGTGTATGACTTCTAGTCTC
TGAACTGGAGCCATCTGAGATCAGTTTGAGATATGGTGTCTTATAAATGTATTGAGAGAGGTTGAGGAGTTGTCTATAGAATGGAATGGA
GTGAGGTCAGAGATCAGTGGCAAGGAAGACCACATAAAGGTTTTTGCACAAACTTGCCTTGATGGCAAGTCCTCAAAAGTACAATTATCA
AGCTTTCTGTTTAAACATGCATAAGTCAGTAAATATAAACATTAAAATTTGCCCAAGACTCTTAACTCAGTTGTATTTCATAATTAAAGT
GTACATTAAAAAGCCAAACTAGTCATGAAAGTATTACATACAGCAAGGGCAGTTTAGATAAGTTAATGTTGCTATGGGAACCCCAGCAGA
TCTCCTTGTGTCTCCGTTTAAAAATCATGGCCCAAGGTGGTTTCAAAAACAACAGAAGGTAAAATTATTCTCACATTCTCACACATGTAA
ATTGTACTGTCTCTCTCAGTTCTAAATAGCGGATTCAAGCCAGCCTCTTGACTGGCACAGTAAAATTCGGCTTCGTGTCTTTCTATAATG
TATTACAGCATGTGAGTTAACCTTTAGAAGCTTCAAAAATACATCAACCAAATTTGGACTGTGAGACACAAACTGGTCTCTTTTGGGCTC
TGTCCAGCATAGCCTTCCTATTCCACATGGCTGCGCAGCAGGGCCATTTCCACCAGTGTCTTCTGCTTGCCTGGTCAGTCTTTCTGTCTC
TTAACCTACCTACAACAACTTCCTTCTCGGGGTTTGCTGCTAGATAGAAATGTAGATTTTGGCACAGAAAGAAAAGGGAAAGACCTATTT
GGAATTTTGTCTATAGATGTTAAGAAATCATGAAGCGTTGCAAATGTAACTGCTTGGGTATTAGTTTAAAATATTTGATAACTGCATGAA
ATTCTAATTTACCCCTCACATCCATAAAGCTAGGACCAGTTGGTTAGGCAGAGTTTGATATTTAAAAATTCATCTTCTGAGAGAGCTGAA
TTTCAAAAGGACCATTTTCTTTCCAGGAGTAAAAGGTATATTCTTTCATCTTCTTACAGTACAGAAACAATGGAATATATTGTTTAAATG
CACCCTTCATTTTTTTCTCCATTTCTAAAAATTCACTTTTGAGCATCGTCCAAATGTAAAAATTCTCACACATGAGGAACTGTTTCCGAA
GGTTGTGAGAAAGTCAAGATAACAGTTTCTATTATTAAAAGTTTTGCATTCGGTATGACACATTTGCCTGTATTGAAACACCCATTTAAC
ATTGACTTCTGAGAACTTATTTGCTTTGCCTCTCTCGATTCCATATGCTTTGTCTACAAATTGTGAACACGTCCCGGTTTCTACCCGTGT
GTGATTCTAAGTCGTTGCTGTACTCTAGCTTGTACGTGAAAATTCACCCATATGCAGATAGCTGCCCTCTTGGAGGCAAAACTTAAAGCT
ATCAGAACCATCTGGATTGTTAAACCCCAAAACTTCCAACTCATCAAAGTCCTGAAGCCTGAATAGATCACACATTGTTACTTCTAATTG
GTTTTGATGTTTGTTATGCTCCTCACAAGTGCAGATAACTTCACATTTGCATCACTAATCGACCTCTTTCAAAGCCTCTGCTCCTCCTGC
TTCCTGCCTCTGTTAGTCATCAGGAGACTTAGTGTTGGCGTGGGTATTTTCCCCGCTTGTGAAAGTGCATTGTCAATTCTAGAGCATTAA
ATATATGTGAGGTATTGTTATTAATCTACAAGGCAGTACACACAGTATTCCAGCAACAGTGACTTTTTCAAAGGTTTTATGAGACATTGT
AAGAAAGACAGTATCTTTCCATGGAAAAAAGTGTTGCCTCAGAGTCAAACAGGAAGCATGGGTCCTAGTTCCTATTGAACTGCTTAGCTA
CTCTTAATTTAGCTCTGAATGCTAGATTTTGTGTATACTATACACATTATTTAATCCTCAAACTCCTAGGAATTCATTTTGATGATAACC
ATTTACAGAAGAGATGTTGGGTAACTTGCTCAGGATACCACATCTAGTAAGTAGCAGAGTCACAACTCGGACCCAGAACTCTCTGATTCC
AAAACCTCTACTTGCTGCTCTTGTAATGGATGGGCCCAAATGCTGCTGGGAAAGGCACCAGGGAAGAAAGAGCTTTCTGAGTCAAGCAGA
AAACGATAGCAGTGGAGAGGAGTTTGTTTCAGACGACCTTCAAGGTTATGGCTCATTCTAGATCCAATCATTCTAGCAAATAAGTAGGTT
ACACTTGTCCACAATTACAAATTGGAAAAGAAGAGAAGGAAAGGAACTGAGAGGAATGACAAAGCAAAAAGCTTTCAATCAGTTCTTTTC
AGCATTCTGCTTCTGCCTAGTTCTGCACTCGCCCCACCCCCTCAGGCTTCAGCCTTCCACTTGGCATCCCTCCTCGCAGAGCACTCTCAC
TTGCATACTCCTCGCTTAAAGAAAAAAAGCATTCTGTACTGCAGTGGGGAAAAAAAACCCTTAAAATGTCTTCAAAAGGATTCAGCTCTA
GGGTAATGTAAAATATGTGAAATCAGGAGGTGTCCATAATAAAATATGAGTGAAAACATCGTTATTTAAAACATTGTATGTACATTAATG
CCACATTAATACCAATTCAGGCATGAAATGTTGAGCATTTCTTGGAATACGGTTTCTTGGAATATGGTTGGGGATTTGAGAGGCGCAAAG
GTACCCGCAAGATGGCTTTGGTGTAGTTATAAATATAAATAGAAGTAAAATAACAGTTGCATCTTCATTTATAATGAATCTATATTGTGG
CCTCAAAGCTACAGAGAAAAGTGGATGCCAAAATCTGTCTTTCATTAACATATGTCTTAAATGACAAGGAAGAGGTGTTGAAGATAAAAT
TACTTTTTCCTATGAGTATGAATCAGCAACATGCAGTAACAAGCAAGTAATAATAGTTCTGCGTGTGAGTGCCTACAGAGGGTAAGAAAA
ATAGCATCAGATTGAAAAAGCAAGTGCACCTGCAGAAGGGACCCAGGAGGCTGCAGAGCACAGCTCCCTTGAGCATCATCTCAAAGTGTC
TCAGAGCACAGTGACCCTAATTCTGGCAAGTCAGGTTGGCATGAGATGGATGGAGCACACTGAAATCTCCAGATGGTCAGACAGCCCACC
CTCAGCTGCCCCTGGAGCTCGGCAAAGGCAAGCTACAAGGCACTGCTACTTGGCCAAGAGTTTAAAACAACAGCTTCTGATTCTACAGTG
TCTGTGGTTTCACAACCACTTAACCTTAAGTAAGGAACAGCTAGAGTTAGCTGAATGAATAAATACACGTTAACGTTACATAAAGAGGGA
AAAAAAGCAATACTTGAGCACATAGACTTCAAATAGTGTCCAGCTAGCTGTGTCCTTGGCATCCCAGTGATCTGGGTCTTTATCTTTGAT
TTTCTCCAGCAGGTAGGCACTGAGTAGATCCAGGGCCCAGGGCGGGAAATGCTTCTGTATCAGATGTTACCTATCAAATAAAATGAGCCT

>96075_96075_4_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000602632_METTL8_chr2_172217023_ENST00000375258_length(amino acids)=412AA_BP=81
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCRDHMQWSKE
EEAAARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSRMHC
PTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAV
ELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCL

--------------------------------------------------------------
>96075_96075_5_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000602710_METTL8_chr2_172217023_ENST00000375258_length(transcript)=8468nt_BP=624nt
TCACTTGGCGCCCGGCGCGGCGAGCGCTACCCGCGGCCCCCGCGCGGCCCTCCCCACAAAGGGCCGCGGAGCTGCGTGGCCGCCGCCGCC
GGCCGTGGCTCGCCTCCGCGGGCGCGGAAATTTGTTGCACTTCTTGGGGCTTTGTTTATTTGTTTGTTTTTTCTCTGGGTTTCTTATTTT
TTTCGTTATTTTGGACAAAATGTCGGTCCGTGATATAAAAATTGAGCGAGGAACCTTGGTGGCATTGGGAGCTTTGCAGAAGGTGCAGTT
TGAATTCTGCTTTTCCCAGGGTGGCAGCTCGGTCTTGGCCGGATGAATCTTCGCTGCTGGCCGTGGAAACAGCTAGAGCAGCTCTTTTCC
AAGAGATAACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTGGCAGTTCAGATGCGGACCA
GCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCCACCCAGCAGAAGAAAAACACCAAACTCTCTAGCAA
AACCACTGCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCTAATTGCAGGGATCA
CATGCAGTGGTCTAAGGAAGAAGAAGCAGCAGCCAGAAAAAAAGTAAAAGAAAACTCAGCTGTGCGAGTCCTTCTGGAAGAGCAAGTTAA
GTATGAGAGAGAAGCTAGTAAATACTGGGACACATTTTACAAGATTCATAAGAATAAGTTTTTCAAGGATCGTAATTGGCTGTTGAGGGA
ATTTCCTGAAATTCTTCCAGTTGATCAAAAACCTGAAGAGAAGGCGAGAGAATCATCATGGGATCATGTAAAAACTAGTGCTACAAATCG
TTTCTCAAGAATGCACTGTCCTACTGTGCCTGATGAAAAAAATCATTATGAGAAAAGTTCTGGTTCTTCAGAAGGTCAAAGCAAAACAGA
ATCTGATTTTTCCAACCTAGACTCTGAAAAACACAAAAAAGGACCTATGGAGACTGGATTGTTTCCTGGTAGCAATGCCACTTTCAGGAT
ACTAGAGGTTGGTTGTGGAGCTGGAAATAGTGTGTTTCCAATTTTGAACACTTTGGAGAACTCTCCGGAGTCCTTTCTGTATTGTTGTGA
TTTTGCTTCTGGAGCTGTGGAGCTCGTAAAGTCACACTCGTCCTACAGAGCAACCCAGTGTTTTGCCTTTGTTCATGATGTATGTGATGA
TGGCTTACCTTACCCTTTTCCAGATGGGATCCTGGATGTCATTCTCCTTGTCTTTGTGCTCTCTTCTATTCATCCTGACAGGATGCAAGG
TGTTGTAAACCGACTGTCCAAGTTACTGAAACCTGGGGGAATGCTGTTATTTCGAGACTATGGAAGATATGATAAGACTCAGCTTCGTTT
TAAAAAGGGACATTGTTTATCTGAAAATTTTTATGTTCGAGGAGATGGTACCAGAGCATATTTCTTTACAAAAGGGGAAGTCCACAGTAT
GTTCTGCAAAGCCAGTTTAGATGAAAAGCAAAATCTGGTTGATCGCCGCTTACAAGTTAATAGGAAAAAACAAGTGAAAATGCACTGAGT
GTGGATTCAAGGCAAATTCCAGAAACCATTGCACCAGACTCAGAATAGCTCCAATATGGTATCTACACTCCTTTCACAAGACTGAACTTT
GTAACATGTTAAGGTACAAAGCCAGAGGACTGTGCTATTCAAGGACTACTGTAAGTCTATTGTTTCTCAAAAGACAATGAGAAAAAAAGA
AGAGAATTTGTATTTCCTGCCGTTTTGTCATAGGTGAGCTCCTTTGTGCATTTTAAGCACATGTAAGTGGTTCAGCACAGTATGCCTTTT
TCTGTGCTTTGAAAACTTGATATGCTCAAGCTTGTTTGAATTTATTACATCTAACCATTTTGCTTGTTCCTTGATTTTTATAAGCATTCA
ATTAAGTTAGTATTATGTCAAGTAATTTTGAGAAAATGTAACTTGACATTTTTTGCAAGTAAAAAAAATTGTTTATTTGTTTAGGCTTAG
TAAACCAGTTCCCAAACACAGTCAGACTCTTCCCATTGTCATCTGATTGCAGAGAGAAAGCACACCTTATTTCCAGGGAAAGCTACAACA
AGCCCAAGGTCAAAGTGTATTATTTTTTGTCTTGTTGTTGTCTATTTTCTCCCAATTTTTTTTTGAAATTCAGAGGCTCATATCTGAAAT
AGAATTTTAGTTCCTCTTTCCTTTCCTAAAATTGGGGAAGTACAGCCCATGCTGACATTATTTTCAGGCTATTCTTAGATATACAAGTTG
TTAGGCCAGGTGCAATGGCTCGCACCTGTAATCCCAGCACTTTGGGGGGCTGAGGCAGGCAGATCGGTTGAGCTCAGGAGTTCAAGACCA
GCCTGGACAACATGGCAAAACCCTGTCTCTCCCAAGAATACAAAAATTAGCCAGGCATGGTGGCACACACCTGTGGTCCCAGCTACTCAG
GAGACTGAGGTGGGAGGATCGCTTGAGCCTCGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTACCACTGCGCTCCAAACTGGGTGACATG
GTGAGACCTTGTCTCCAAAAAAAAAAAAAAAAAAAAAAAAGGTATGTAAGCTGACAAGCTCTTGTATCAAGGGCTTTTGAACCAGAGCAA
CTTCATCTTGAATAGGGACTGTGTAAAATGAAGCTGAGACCTACTAGGCTGCAATCCCAGGAGGTTAAGACATTCTTAGTCACAGGATGA
GATAGGAAGTCAGTACAAGATACAGGTCATACAGACCTTGCTGATAAAACAGGTTGCAGTGAAGAAGCCGGCCAAATGCCACCAAAACCA
AGATGGCAATGAGAGTGTCCTCTGGCTGTCCTCACTGCTACACTCCCACCAGTGCCATGATAGTTTACAAATGCCATGGCAACATCAGGA
AGTTACCCATATGGTCTACAAAGGGGAGGCCTGAATAATCCACCCCTTGTGTAGCATATAATCAAGAAATAACCTTAAAAATGGGCAACC
AGTAGCCCTTGGGGCTGCTCTGCCTATGGAGTAGCCATTCTTTATGTTTTACTTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTC
TGGCACCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCCAGCTCCACCTCCCGGGTTCACGCCATTCTCTTGCTTCAGCCTCCT
GAGTAGCTGGGACTACAAGCACCCACCACCATGCCCAGCTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTA
GCCAGGATGGTCTCAATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCCAG
CCTATTCTTTACTTAAACTTGTTTTCACTTTGCTGTATGGACTCAATTCTTTCTTGCACAAGATCCAAGAATCCTCTCTTGGCGTCTGGA
TCCAGACCCTTTCTGGTATCAGTGGTAAGCTCTGTTTAAGACAACTGTCATACCCAAGAGAATTCTTAAATTGTGGCAGTTAAAAATGTA
TTTATCCCCTCGAGGGCCGGGCGCAGTCGCTCAAGCCCGTAATCCCAGCACTTTGGGAGGCCGAGGAGGCGGATCATGAGGTCAGGAGTT
CAAGACCAGCCTGACCAACACTGTGAAACCCTGTCTCTACTAAAAATACAAAAAAAATTAGCCAGGCGTGGTGGTGGGCACCTGTAATCC
CAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATGACACCACTGCCCTCCAGCC
TGGGTGACAGTTGTTAGACTGCGTATCAAAAAAAAAAAAAAAAATTTATTTACTCCCTTGCTTCAAAAAGGACATAAGTTGGCTTGCAAA
TCACATTTTGTAGAAATGAAGTTTTTAAGATTAGTCTCATACTCATTACATAATATTTATTGACTACTTACATATTGAGTGCTAAATTCA
GTGGAATAATATGAACAATAAAGACCCAGCCTTGTTTATGCTCTTCAGGGAGCATAAATAGAGTACAGCTGGCAAAACAAAATGTGCATA
TCCCAAACCTGTAAATCATGATCTAAGACAATATACAAACACTCAAATAGGGAACTTACCAGCTAGCAGACTTTGATTATGAACCACAGA
ACCTAGAATAAATAAATACTCTCTTGAAAGAACCATCATTGGAATAATTAAGTTCCAACTGTTTTTTCTTTCTGAATTCACTTAAAATCC
AATTTCTAGAAGAATATCATTGGTCCAGCTTTAGTCATTGGTTCATCTCTTAACAGGCTGGGGCAGGGCAGCTTAATTGATGATGCCACC
AGAATGGGCAACATGGGAAAAACCCTATCTCTACCAAAAATACAAAAATTAGCCAGTGATGGTGGCACGCACCTGTTGTCCCAGCTACTC
AGGAGGCTGAGCTGGGAGGATCTTTTGAGCCTGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCACTCCAACCTGGAGTGGA
AGGAAATTTCACTTCCTGGAATGGAAGAAAGTTCTTCAAAGGAAAATCAAGACACTGCTGTCAAAAAACACCAGGGGAGGGATGCTGTCC
AGTCACAGCCAACACATCATATAGCAGTGGTAGCAGTAGTAATAGTATTTCCAGAGAGAGAGAGAGAGATTAGCTCTGAAAAAGAATGGA
GAAGAATCAGGTTTCTTGGGGGAGGTAGGTCTCAGGCTAGTTCTTGAATGTACATTCTCAGCAGATGGTGAGAAGACAAGTGTGGTGTGG
GACATTAATGATGAGGGATAGGTAGAAAAGATGGGAAGGGGGTCAGCTTGTAGATAACCTAGACTAGCAGGTGTATGACTTCTAGTCTCT
GAACTGGAGCCATCTGAGATCAGTTTGAGATATGGTGTCTTATAAATGTATTGAGAGAGGTTGAGGAGTTGTCTATAGAATGGAATGGAG
TGAGGTCAGAGATCAGTGGCAAGGAAGACCACATAAAGGTTTTTGCACAAACTTGCCTTGATGGCAAGTCCTCAAAAGTACAATTATCAA
GCTTTCTGTTTAAACATGCATAAGTCAGTAAATATAAACATTAAAATTTGCCCAAGACTCTTAACTCAGTTGTATTTCATAATTAAAGTG
TACATTAAAAAGCCAAACTAGTCATGAAAGTATTACATACAGCAAGGGCAGTTTAGATAAGTTAATGTTGCTATGGGAACCCCAGCAGAT
CTCCTTGTGTCTCCGTTTAAAAATCATGGCCCAAGGTGGTTTCAAAAACAACAGAAGGTAAAATTATTCTCACATTCTCACACATGTAAA
TTGTACTGTCTCTCTCAGTTCTAAATAGCGGATTCAAGCCAGCCTCTTGACTGGCACAGTAAAATTCGGCTTCGTGTCTTTCTATAATGT
ATTACAGCATGTGAGTTAACCTTTAGAAGCTTCAAAAATACATCAACCAAATTTGGACTGTGAGACACAAACTGGTCTCTTTTGGGCTCT
GTCCAGCATAGCCTTCCTATTCCACATGGCTGCGCAGCAGGGCCATTTCCACCAGTGTCTTCTGCTTGCCTGGTCAGTCTTTCTGTCTCT
TAACCTACCTACAACAACTTCCTTCTCGGGGTTTGCTGCTAGATAGAAATGTAGATTTTGGCACAGAAAGAAAAGGGAAAGACCTATTTG
GAATTTTGTCTATAGATGTTAAGAAATCATGAAGCGTTGCAAATGTAACTGCTTGGGTATTAGTTTAAAATATTTGATAACTGCATGAAA
TTCTAATTTACCCCTCACATCCATAAAGCTAGGACCAGTTGGTTAGGCAGAGTTTGATATTTAAAAATTCATCTTCTGAGAGAGCTGAAT
TTCAAAAGGACCATTTTCTTTCCAGGAGTAAAAGGTATATTCTTTCATCTTCTTACAGTACAGAAACAATGGAATATATTGTTTAAATGC
ACCCTTCATTTTTTTCTCCATTTCTAAAAATTCACTTTTGAGCATCGTCCAAATGTAAAAATTCTCACACATGAGGAACTGTTTCCGAAG
GTTGTGAGAAAGTCAAGATAACAGTTTCTATTATTAAAAGTTTTGCATTCGGTATGACACATTTGCCTGTATTGAAACACCCATTTAACA
TTGACTTCTGAGAACTTATTTGCTTTGCCTCTCTCGATTCCATATGCTTTGTCTACAAATTGTGAACACGTCCCGGTTTCTACCCGTGTG
TGATTCTAAGTCGTTGCTGTACTCTAGCTTGTACGTGAAAATTCACCCATATGCAGATAGCTGCCCTCTTGGAGGCAAAACTTAAAGCTA
TCAGAACCATCTGGATTGTTAAACCCCAAAACTTCCAACTCATCAAAGTCCTGAAGCCTGAATAGATCACACATTGTTACTTCTAATTGG
TTTTGATGTTTGTTATGCTCCTCACAAGTGCAGATAACTTCACATTTGCATCACTAATCGACCTCTTTCAAAGCCTCTGCTCCTCCTGCT
TCCTGCCTCTGTTAGTCATCAGGAGACTTAGTGTTGGCGTGGGTATTTTCCCCGCTTGTGAAAGTGCATTGTCAATTCTAGAGCATTAAA
TATATGTGAGGTATTGTTATTAATCTACAAGGCAGTACACACAGTATTCCAGCAACAGTGACTTTTTCAAAGGTTTTATGAGACATTGTA
AGAAAGACAGTATCTTTCCATGGAAAAAAGTGTTGCCTCAGAGTCAAACAGGAAGCATGGGTCCTAGTTCCTATTGAACTGCTTAGCTAC
TCTTAATTTAGCTCTGAATGCTAGATTTTGTGTATACTATACACATTATTTAATCCTCAAACTCCTAGGAATTCATTTTGATGATAACCA
TTTACAGAAGAGATGTTGGGTAACTTGCTCAGGATACCACATCTAGTAAGTAGCAGAGTCACAACTCGGACCCAGAACTCTCTGATTCCA
AAACCTCTACTTGCTGCTCTTGTAATGGATGGGCCCAAATGCTGCTGGGAAAGGCACCAGGGAAGAAAGAGCTTTCTGAGTCAAGCAGAA
AACGATAGCAGTGGAGAGGAGTTTGTTTCAGACGACCTTCAAGGTTATGGCTCATTCTAGATCCAATCATTCTAGCAAATAAGTAGGTTA
CACTTGTCCACAATTACAAATTGGAAAAGAAGAGAAGGAAAGGAACTGAGAGGAATGACAAAGCAAAAAGCTTTCAATCAGTTCTTTTCA
GCATTCTGCTTCTGCCTAGTTCTGCACTCGCCCCACCCCCTCAGGCTTCAGCCTTCCACTTGGCATCCCTCCTCGCAGAGCACTCTCACT
TGCATACTCCTCGCTTAAAGAAAAAAAGCATTCTGTACTGCAGTGGGGAAAAAAAACCCTTAAAATGTCTTCAAAAGGATTCAGCTCTAG
GGTAATGTAAAATATGTGAAATCAGGAGGTGTCCATAATAAAATATGAGTGAAAACATCGTTATTTAAAACATTGTATGTACATTAATGC
CACATTAATACCAATTCAGGCATGAAATGTTGAGCATTTCTTGGAATACGGTTTCTTGGAATATGGTTGGGGATTTGAGAGGCGCAAAGG
TACCCGCAAGATGGCTTTGGTGTAGTTATAAATATAAATAGAAGTAAAATAACAGTTGCATCTTCATTTATAATGAATCTATATTGTGGC
CTCAAAGCTACAGAGAAAAGTGGATGCCAAAATCTGTCTTTCATTAACATATGTCTTAAATGACAAGGAAGAGGTGTTGAAGATAAAATT
ACTTTTTCCTATGAGTATGAATCAGCAACATGCAGTAACAAGCAAGTAATAATAGTTCTGCGTGTGAGTGCCTACAGAGGGTAAGAAAAA
TAGCATCAGATTGAAAAAGCAAGTGCACCTGCAGAAGGGACCCAGGAGGCTGCAGAGCACAGCTCCCTTGAGCATCATCTCAAAGTGTCT
CAGAGCACAGTGACCCTAATTCTGGCAAGTCAGGTTGGCATGAGATGGATGGAGCACACTGAAATCTCCAGATGGTCAGACAGCCCACCC
TCAGCTGCCCCTGGAGCTCGGCAAAGGCAAGCTACAAGGCACTGCTACTTGGCCAAGAGTTTAAAACAACAGCTTCTGATTCTACAGTGT
CTGTGGTTTCACAACCACTTAACCTTAAGTAAGGAACAGCTAGAGTTAGCTGAATGAATAAATACACGTTAACGTTACATAAAGAGGGAA
AAAAAGCAATACTTGAGCACATAGACTTCAAATAGTGTCCAGCTAGCTGTGTCCTTGGCATCCCAGTGATCTGGGTCTTTATCTTTGATT
TTCTCCAGCAGGTAGGCACTGAGTAGATCCAGGGCCCAGGGCGGGAAATGCTTCTGTATCAGATGTTACCTATCAAATAAAATGAGCCTT

>96075_96075_5_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000602710_METTL8_chr2_172217023_ENST00000375258_length(amino acids)=412AA_BP=81
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCRDHMQWSKE
EEAAARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSRMHC
PTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAV
ELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCL

--------------------------------------------------------------
>96075_96075_6_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000602959_METTL8_chr2_172217023_ENST00000375258_length(transcript)=8233nt_BP=389nt
CGGCCAAGGGCGGCAGGGGCCAGCCCGCCGGGTCCCCGCCGCGCTCTTTGTCCTGGCCGCGCGCGGGCGGACGCGTGCACCCCCAGGCGG
CGCGCGAGCGGGCCGGGCGGGCGGCCGAGTTTTCCAAGAGATAACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGC
CCCAGCACCAGCAGTGGCAGTTCAGATGCGGACCAGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCC
ACCCAGCAGAAGAAAAACACCAAACTCTCTAGCAAAACCACTGCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAA
ATAACCCTTGATCCTCCTCCTAATTGCAGGGATCACATGCAGTGGTCTAAGGAAGAAGAAGCAGCAGCCAGAAAAAAAGTAAAAGAAAAC
TCAGCTGTGCGAGTCCTTCTGGAAGAGCAAGTTAAGTATGAGAGAGAAGCTAGTAAATACTGGGACACATTTTACAAGATTCATAAGAAT
AAGTTTTTCAAGGATCGTAATTGGCTGTTGAGGGAATTTCCTGAAATTCTTCCAGTTGATCAAAAACCTGAAGAGAAGGCGAGAGAATCA
TCATGGGATCATGTAAAAACTAGTGCTACAAATCGTTTCTCAAGAATGCACTGTCCTACTGTGCCTGATGAAAAAAATCATTATGAGAAA
AGTTCTGGTTCTTCAGAAGGTCAAAGCAAAACAGAATCTGATTTTTCCAACCTAGACTCTGAAAAACACAAAAAAGGACCTATGGAGACT
GGATTGTTTCCTGGTAGCAATGCCACTTTCAGGATACTAGAGGTTGGTTGTGGAGCTGGAAATAGTGTGTTTCCAATTTTGAACACTTTG
GAGAACTCTCCGGAGTCCTTTCTGTATTGTTGTGATTTTGCTTCTGGAGCTGTGGAGCTCGTAAAGTCACACTCGTCCTACAGAGCAACC
CAGTGTTTTGCCTTTGTTCATGATGTATGTGATGATGGCTTACCTTACCCTTTTCCAGATGGGATCCTGGATGTCATTCTCCTTGTCTTT
GTGCTCTCTTCTATTCATCCTGACAGGATGCAAGGTGTTGTAAACCGACTGTCCAAGTTACTGAAACCTGGGGGAATGCTGTTATTTCGA
GACTATGGAAGATATGATAAGACTCAGCTTCGTTTTAAAAAGGGACATTGTTTATCTGAAAATTTTTATGTTCGAGGAGATGGTACCAGA
GCATATTTCTTTACAAAAGGGGAAGTCCACAGTATGTTCTGCAAAGCCAGTTTAGATGAAAAGCAAAATCTGGTTGATCGCCGCTTACAA
GTTAATAGGAAAAAACAAGTGAAAATGCACTGAGTGTGGATTCAAGGCAAATTCCAGAAACCATTGCACCAGACTCAGAATAGCTCCAAT
ATGGTATCTACACTCCTTTCACAAGACTGAACTTTGTAACATGTTAAGGTACAAAGCCAGAGGACTGTGCTATTCAAGGACTACTGTAAG
TCTATTGTTTCTCAAAAGACAATGAGAAAAAAAGAAGAGAATTTGTATTTCCTGCCGTTTTGTCATAGGTGAGCTCCTTTGTGCATTTTA
AGCACATGTAAGTGGTTCAGCACAGTATGCCTTTTTCTGTGCTTTGAAAACTTGATATGCTCAAGCTTGTTTGAATTTATTACATCTAAC
CATTTTGCTTGTTCCTTGATTTTTATAAGCATTCAATTAAGTTAGTATTATGTCAAGTAATTTTGAGAAAATGTAACTTGACATTTTTTG
CAAGTAAAAAAAATTGTTTATTTGTTTAGGCTTAGTAAACCAGTTCCCAAACACAGTCAGACTCTTCCCATTGTCATCTGATTGCAGAGA
GAAAGCACACCTTATTTCCAGGGAAAGCTACAACAAGCCCAAGGTCAAAGTGTATTATTTTTTGTCTTGTTGTTGTCTATTTTCTCCCAA
TTTTTTTTTGAAATTCAGAGGCTCATATCTGAAATAGAATTTTAGTTCCTCTTTCCTTTCCTAAAATTGGGGAAGTACAGCCCATGCTGA
CATTATTTTCAGGCTATTCTTAGATATACAAGTTGTTAGGCCAGGTGCAATGGCTCGCACCTGTAATCCCAGCACTTTGGGGGGCTGAGG
CAGGCAGATCGGTTGAGCTCAGGAGTTCAAGACCAGCCTGGACAACATGGCAAAACCCTGTCTCTCCCAAGAATACAAAAATTAGCCAGG
CATGGTGGCACACACCTGTGGTCCCAGCTACTCAGGAGACTGAGGTGGGAGGATCGCTTGAGCCTCGGAGGCGGAGGTTGCAGTGAGCTG
AGATTGTACCACTGCGCTCCAAACTGGGTGACATGGTGAGACCTTGTCTCCAAAAAAAAAAAAAAAAAAAAAAAAGGTATGTAAGCTGAC
AAGCTCTTGTATCAAGGGCTTTTGAACCAGAGCAACTTCATCTTGAATAGGGACTGTGTAAAATGAAGCTGAGACCTACTAGGCTGCAAT
CCCAGGAGGTTAAGACATTCTTAGTCACAGGATGAGATAGGAAGTCAGTACAAGATACAGGTCATACAGACCTTGCTGATAAAACAGGTT
GCAGTGAAGAAGCCGGCCAAATGCCACCAAAACCAAGATGGCAATGAGAGTGTCCTCTGGCTGTCCTCACTGCTACACTCCCACCAGTGC
CATGATAGTTTACAAATGCCATGGCAACATCAGGAAGTTACCCATATGGTCTACAAAGGGGAGGCCTGAATAATCCACCCCTTGTGTAGC
ATATAATCAAGAAATAACCTTAAAAATGGGCAACCAGTAGCCCTTGGGGCTGCTCTGCCTATGGAGTAGCCATTCTTTATGTTTTACTTT
TTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTGGCACCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCCAGCTCCACCT
CCCGGGTTCACGCCATTCTCTTGCTTCAGCCTCCTGAGTAGCTGGGACTACAAGCACCCACCACCATGCCCAGCTAATTTTTTTTTTTTT
TGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGATCCGCCCGCCTCGGCCTCCCAAA
GTGCTGGGATTACAGGTGTGAGCCACCGCGCCCAGCCTATTCTTTACTTAAACTTGTTTTCACTTTGCTGTATGGACTCAATTCTTTCTT
GCACAAGATCCAAGAATCCTCTCTTGGCGTCTGGATCCAGACCCTTTCTGGTATCAGTGGTAAGCTCTGTTTAAGACAACTGTCATACCC
AAGAGAATTCTTAAATTGTGGCAGTTAAAAATGTATTTATCCCCTCGAGGGCCGGGCGCAGTCGCTCAAGCCCGTAATCCCAGCACTTTG
GGAGGCCGAGGAGGCGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGACCAACACTGTGAAACCCTGTCTCTACTAAAAATACAAAAAA
AATTAGCCAGGCGTGGTGGTGGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGGTT
GCAGTGAGCCGAGATGACACCACTGCCCTCCAGCCTGGGTGACAGTTGTTAGACTGCGTATCAAAAAAAAAAAAAAAAATTTATTTACTC
CCTTGCTTCAAAAAGGACATAAGTTGGCTTGCAAATCACATTTTGTAGAAATGAAGTTTTTAAGATTAGTCTCATACTCATTACATAATA
TTTATTGACTACTTACATATTGAGTGCTAAATTCAGTGGAATAATATGAACAATAAAGACCCAGCCTTGTTTATGCTCTTCAGGGAGCAT
AAATAGAGTACAGCTGGCAAAACAAAATGTGCATATCCCAAACCTGTAAATCATGATCTAAGACAATATACAAACACTCAAATAGGGAAC
TTACCAGCTAGCAGACTTTGATTATGAACCACAGAACCTAGAATAAATAAATACTCTCTTGAAAGAACCATCATTGGAATAATTAAGTTC
CAACTGTTTTTTCTTTCTGAATTCACTTAAAATCCAATTTCTAGAAGAATATCATTGGTCCAGCTTTAGTCATTGGTTCATCTCTTAACA
GGCTGGGGCAGGGCAGCTTAATTGATGATGCCACCAGAATGGGCAACATGGGAAAAACCCTATCTCTACCAAAAATACAAAAATTAGCCA
GTGATGGTGGCACGCACCTGTTGTCCCAGCTACTCAGGAGGCTGAGCTGGGAGGATCTTTTGAGCCTGGGAGGCAGAGGTTGCAGTGAGC
TGAGATCGCACCACTGCACTCCAACCTGGAGTGGAAGGAAATTTCACTTCCTGGAATGGAAGAAAGTTCTTCAAAGGAAAATCAAGACAC
TGCTGTCAAAAAACACCAGGGGAGGGATGCTGTCCAGTCACAGCCAACACATCATATAGCAGTGGTAGCAGTAGTAATAGTATTTCCAGA
GAGAGAGAGAGAGATTAGCTCTGAAAAAGAATGGAGAAGAATCAGGTTTCTTGGGGGAGGTAGGTCTCAGGCTAGTTCTTGAATGTACAT
TCTCAGCAGATGGTGAGAAGACAAGTGTGGTGTGGGACATTAATGATGAGGGATAGGTAGAAAAGATGGGAAGGGGGTCAGCTTGTAGAT
AACCTAGACTAGCAGGTGTATGACTTCTAGTCTCTGAACTGGAGCCATCTGAGATCAGTTTGAGATATGGTGTCTTATAAATGTATTGAG
AGAGGTTGAGGAGTTGTCTATAGAATGGAATGGAGTGAGGTCAGAGATCAGTGGCAAGGAAGACCACATAAAGGTTTTTGCACAAACTTG
CCTTGATGGCAAGTCCTCAAAAGTACAATTATCAAGCTTTCTGTTTAAACATGCATAAGTCAGTAAATATAAACATTAAAATTTGCCCAA
GACTCTTAACTCAGTTGTATTTCATAATTAAAGTGTACATTAAAAAGCCAAACTAGTCATGAAAGTATTACATACAGCAAGGGCAGTTTA
GATAAGTTAATGTTGCTATGGGAACCCCAGCAGATCTCCTTGTGTCTCCGTTTAAAAATCATGGCCCAAGGTGGTTTCAAAAACAACAGA
AGGTAAAATTATTCTCACATTCTCACACATGTAAATTGTACTGTCTCTCTCAGTTCTAAATAGCGGATTCAAGCCAGCCTCTTGACTGGC
ACAGTAAAATTCGGCTTCGTGTCTTTCTATAATGTATTACAGCATGTGAGTTAACCTTTAGAAGCTTCAAAAATACATCAACCAAATTTG
GACTGTGAGACACAAACTGGTCTCTTTTGGGCTCTGTCCAGCATAGCCTTCCTATTCCACATGGCTGCGCAGCAGGGCCATTTCCACCAG
TGTCTTCTGCTTGCCTGGTCAGTCTTTCTGTCTCTTAACCTACCTACAACAACTTCCTTCTCGGGGTTTGCTGCTAGATAGAAATGTAGA
TTTTGGCACAGAAAGAAAAGGGAAAGACCTATTTGGAATTTTGTCTATAGATGTTAAGAAATCATGAAGCGTTGCAAATGTAACTGCTTG
GGTATTAGTTTAAAATATTTGATAACTGCATGAAATTCTAATTTACCCCTCACATCCATAAAGCTAGGACCAGTTGGTTAGGCAGAGTTT
GATATTTAAAAATTCATCTTCTGAGAGAGCTGAATTTCAAAAGGACCATTTTCTTTCCAGGAGTAAAAGGTATATTCTTTCATCTTCTTA
CAGTACAGAAACAATGGAATATATTGTTTAAATGCACCCTTCATTTTTTTCTCCATTTCTAAAAATTCACTTTTGAGCATCGTCCAAATG
TAAAAATTCTCACACATGAGGAACTGTTTCCGAAGGTTGTGAGAAAGTCAAGATAACAGTTTCTATTATTAAAAGTTTTGCATTCGGTAT
GACACATTTGCCTGTATTGAAACACCCATTTAACATTGACTTCTGAGAACTTATTTGCTTTGCCTCTCTCGATTCCATATGCTTTGTCTA
CAAATTGTGAACACGTCCCGGTTTCTACCCGTGTGTGATTCTAAGTCGTTGCTGTACTCTAGCTTGTACGTGAAAATTCACCCATATGCA
GATAGCTGCCCTCTTGGAGGCAAAACTTAAAGCTATCAGAACCATCTGGATTGTTAAACCCCAAAACTTCCAACTCATCAAAGTCCTGAA
GCCTGAATAGATCACACATTGTTACTTCTAATTGGTTTTGATGTTTGTTATGCTCCTCACAAGTGCAGATAACTTCACATTTGCATCACT
AATCGACCTCTTTCAAAGCCTCTGCTCCTCCTGCTTCCTGCCTCTGTTAGTCATCAGGAGACTTAGTGTTGGCGTGGGTATTTTCCCCGC
TTGTGAAAGTGCATTGTCAATTCTAGAGCATTAAATATATGTGAGGTATTGTTATTAATCTACAAGGCAGTACACACAGTATTCCAGCAA
CAGTGACTTTTTCAAAGGTTTTATGAGACATTGTAAGAAAGACAGTATCTTTCCATGGAAAAAAGTGTTGCCTCAGAGTCAAACAGGAAG
CATGGGTCCTAGTTCCTATTGAACTGCTTAGCTACTCTTAATTTAGCTCTGAATGCTAGATTTTGTGTATACTATACACATTATTTAATC
CTCAAACTCCTAGGAATTCATTTTGATGATAACCATTTACAGAAGAGATGTTGGGTAACTTGCTCAGGATACCACATCTAGTAAGTAGCA
GAGTCACAACTCGGACCCAGAACTCTCTGATTCCAAAACCTCTACTTGCTGCTCTTGTAATGGATGGGCCCAAATGCTGCTGGGAAAGGC
ACCAGGGAAGAAAGAGCTTTCTGAGTCAAGCAGAAAACGATAGCAGTGGAGAGGAGTTTGTTTCAGACGACCTTCAAGGTTATGGCTCAT
TCTAGATCCAATCATTCTAGCAAATAAGTAGGTTACACTTGTCCACAATTACAAATTGGAAAAGAAGAGAAGGAAAGGAACTGAGAGGAA
TGACAAAGCAAAAAGCTTTCAATCAGTTCTTTTCAGCATTCTGCTTCTGCCTAGTTCTGCACTCGCCCCACCCCCTCAGGCTTCAGCCTT
CCACTTGGCATCCCTCCTCGCAGAGCACTCTCACTTGCATACTCCTCGCTTAAAGAAAAAAAGCATTCTGTACTGCAGTGGGGAAAAAAA
ACCCTTAAAATGTCTTCAAAAGGATTCAGCTCTAGGGTAATGTAAAATATGTGAAATCAGGAGGTGTCCATAATAAAATATGAGTGAAAA
CATCGTTATTTAAAACATTGTATGTACATTAATGCCACATTAATACCAATTCAGGCATGAAATGTTGAGCATTTCTTGGAATACGGTTTC
TTGGAATATGGTTGGGGATTTGAGAGGCGCAAAGGTACCCGCAAGATGGCTTTGGTGTAGTTATAAATATAAATAGAAGTAAAATAACAG
TTGCATCTTCATTTATAATGAATCTATATTGTGGCCTCAAAGCTACAGAGAAAAGTGGATGCCAAAATCTGTCTTTCATTAACATATGTC
TTAAATGACAAGGAAGAGGTGTTGAAGATAAAATTACTTTTTCCTATGAGTATGAATCAGCAACATGCAGTAACAAGCAAGTAATAATAG
TTCTGCGTGTGAGTGCCTACAGAGGGTAAGAAAAATAGCATCAGATTGAAAAAGCAAGTGCACCTGCAGAAGGGACCCAGGAGGCTGCAG
AGCACAGCTCCCTTGAGCATCATCTCAAAGTGTCTCAGAGCACAGTGACCCTAATTCTGGCAAGTCAGGTTGGCATGAGATGGATGGAGC
ACACTGAAATCTCCAGATGGTCAGACAGCCCACCCTCAGCTGCCCCTGGAGCTCGGCAAAGGCAAGCTACAAGGCACTGCTACTTGGCCA
AGAGTTTAAAACAACAGCTTCTGATTCTACAGTGTCTGTGGTTTCACAACCACTTAACCTTAAGTAAGGAACAGCTAGAGTTAGCTGAAT
GAATAAATACACGTTAACGTTACATAAAGAGGGAAAAAAAGCAATACTTGAGCACATAGACTTCAAATAGTGTCCAGCTAGCTGTGTCCT
TGGCATCCCAGTGATCTGGGTCTTTATCTTTGATTTTCTCCAGCAGGTAGGCACTGAGTAGATCCAGGGCCCAGGGCGGGAAATGCTTCT

>96075_96075_6_UBE2E3-METTL8_UBE2E3_chr2_181848820_ENST00000602959_METTL8_chr2_172217023_ENST00000375258_length(amino acids)=412AA_BP=81
MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCRDHMQWSKE
EEAAARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSRMHC
PTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAV
ELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UBE2E3-METTL8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for UBE2E3-METTL8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for UBE2E3-METTL8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource