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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UBE2E3-SLC9A7 (FusionGDB2 ID:96076)

Fusion Gene Summary for UBE2E3-SLC9A7

Fusion gene summary

Fusion gene information	Fusion gene name: UBE2E3-SLC9A7
	Fusion gene ID: 96076
		Hgene	Tgene
	Gene symbol	UBE2E3	SLC9A7
	Gene ID	10477	84679
	Gene name	ubiquitin conjugating enzyme E2 E3	solute carrier family 9 member A7
	Synonyms	UBCH9\|UbcM2	MRX108\|NHE-7\|NHE7\|SLC9A6
	Cytomap	2q31.3	Xp11.3\|Xp11.3
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin-conjugating enzyme E2 E3E2 ubiquitin-conjugating enzyme E3ubiquitin carrier protein E3ubiquitin conjugating enzyme E2E 3ubiquitin-conjugating enzyme E2-23 kDaubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)ubiquitin-conjugating e	sodium/hydrogen exchanger 7Na(+)/H(+) exchanger 7nonselective sodium potassium/proton exchangersolute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000392415, ENST00000410062, ENST00000602475, ENST00000602632, ENST00000602710, ENST00000602959, ENST00000602837,	ENST00000464933, ENST00000328306,
Fusion gene scores	* DoF score	10 X 6 X 6=360	6 X 6 X 3=108
	# samples	10	7
	** MAII score	log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UBE2E3 [Title/Abstract] AND SLC9A7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UBE2E3(181848820)-SLC9A7(46466638), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBE2E3	GO:0070534	protein K63-linked ubiquitination	20061386
Hgene	UBE2E3	GO:0070936	protein K48-linked ubiquitination	20061386
Hgene	UBE2E3	GO:0070979	protein K11-linked ubiquitination	20061386
Tgene	SLC9A7	GO:0006885	regulation of pH	11279194

Fusion gene breakpoints across UBE2E3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC9A7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GN-01A	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-

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Fusion Gene ORF analysis for UBE2E3-SLC9A7

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000392415	ENST00000464933	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
5CDS-5UTR	ENST00000410062	ENST00000464933	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
5CDS-5UTR	ENST00000602475	ENST00000464933	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
5CDS-5UTR	ENST00000602632	ENST00000464933	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
5CDS-5UTR	ENST00000602710	ENST00000464933	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
5CDS-5UTR	ENST00000602959	ENST00000464933	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
In-frame	ENST00000392415	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
In-frame	ENST00000410062	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
In-frame	ENST00000602475	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
In-frame	ENST00000602632	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
In-frame	ENST00000602710	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
In-frame	ENST00000602959	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
intron-3CDS	ENST00000602837	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-
intron-5UTR	ENST00000602837	ENST00000464933	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000392415	UBE2E3	chr2	181848820	+	ENST00000328306	SLC9A7	chrX	46466638	-	2349	463	35	478	147
ENST00000410062	UBE2E3	chr2	181848820	+	ENST00000328306	SLC9A7	chrX	46466638	-	2524	638	11	382	123
ENST00000602710	UBE2E3	chr2	181848820	+	ENST00000328306	SLC9A7	chrX	46466638	-	2510	624	221	589	122
ENST00000602959	UBE2E3	chr2	181848820	+	ENST00000328306	SLC9A7	chrX	46466638	-	2275	389	52	354	100
ENST00000602475	UBE2E3	chr2	181848820	+	ENST00000328306	SLC9A7	chrX	46466638	-	2323	437	192	452	86
ENST00000602632	UBE2E3	chr2	181848820	+	ENST00000328306	SLC9A7	chrX	46466638	-	2151	265	20	280	86

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000392415	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-	0.09644967	0.9035503
ENST00000410062	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-	0.07883944	0.9211606
ENST00000602710	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-	0.024749601	0.97525036
ENST00000602959	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-	0.015883092	0.984117
ENST00000602475	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-	0.13331778	0.86668223
ENST00000602632	ENST00000328306	UBE2E3	chr2	181848820	+	SLC9A7	chrX	46466638	-	0.10436212	0.89563787

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Fusion Genomic Features for UBE2E3-SLC9A7

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBE2E3-SLC9A7

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:181848820/chrX:46466638)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBE2E3

chr2:181848820

chrX:46466638

ENST00000392415

61_207

208.0

Domain

UBC core

Hgene

UBE2E3

chr2:181848820

chrX:46466638

ENST00000410062

61_207

208.0

Domain

UBC core

Hgene

UBE2E3

chr2:181848820

chrX:46466638

ENST00000602710

61_207

208.0

Domain

UBC core

Hgene

UBE2E3

chr2:181848820

chrX:46466638

ENST00000602959

61_207

208.0

Domain

UBC core

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

117_175

642

726.0

Topological domain

Lumenal

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

197_210

642

726.0

Topological domain

Cytoplasmic

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

1_21

642

726.0

Topological domain

Cytoplasmic

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

232_251

642

726.0

Topological domain

Lumenal

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

273_277

642

726.0

Topological domain

Cytoplasmic

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

299_322

642

726.0

Topological domain

Lumenal

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

344_349

642

726.0

Topological domain

Cytoplasmic

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

392_414

642

726.0

Topological domain

Cytoplasmic

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

436_442

642

726.0

Topological domain

Lumenal

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

43_70

642

726.0

Topological domain

Lumenal

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

464_474

642

726.0

Topological domain

Cytoplasmic

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

498_513

642

726.0

Topological domain

Lumenal

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

535_725

642

726.0

Topological domain

Cytoplasmic

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

92_95

642

726.0

Topological domain

Cytoplasmic

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

176_196

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

211_231

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

22_42

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

252_272

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

278_298

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

323_343

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

350_370

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

371_391

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

415_435

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

443_463

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

475_497

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

514_534

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

71_91

642

726.0

Transmembrane

Helical

Tgene

SLC9A7

chr2:181848820

chrX:46466638

ENST00000328306

96_116

642

726.0

Transmembrane

Helical

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Fusion Gene Sequence for UBE2E3-SLC9A7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>96076_96076_1_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000392415_SLC9A7_chrX_46466638_ENST00000328306_length(transcript)=2349nt_BP=463nt
GCAGGGGCCAGCCCGCCGGGTCCCCGCCGCGCTCTTTGTCCTGGCCGCGCGCGGGCGGACGCGTGCACCCCCAGGGTGAGGGGAGGTGTG
GAGAGCGCGCACGGGAGCGCGCGGGAACAGCTCGCGCCCGCCGGGCGTCGGCGGCGCGCGCCCCTCCGCCAGGCAAGCAGCGAGCACGCG
CGTCGCCGCCGAGTTTTCCAAGAGATAACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTG
GCAGTTCAGATGCGGACCAGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCCACCCAGCAGAAGAAAA
ACACCAAACTCTCTAGCAAAACCACTGCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTC
CTCCTAATTGCAGAACCAAGAGCCACTGAGAGAGGAAGACTCTGATTTCATCCTGACCGAAGGCGACCTGACATTGACCTACGGGGACAG
CACAGTGACTGCAAATGGCTCCTCAAGTTCGCACACCGCCTCCACGAGTCTGGAGGGCAGCCGGAGAACGAAGAGCAGCTCGGAGGAAGT
GCTGGAGCGAGACCTGGGAATGGGAGACCAGAAGGTTTCGAGCCGGGGCACCCGCCTAGTGTTTCCCCTGGAAGATAATGCTTGACTTTC
CCCCCAAGCCCTGGCGCGATGGGGTAGGCTCCCGATGGGGTGAGGACAGCTGCAAGCCCTAGTGTTGTTGGAGGTGGGGCAGTGACTAGA
TTGAACTAACTCTTCTATTTTATTGGGGTCTGAAGCTATTGTAACACTTAAAATTTAACTCACAATGCAGATGGTGAGGCAAAAGTGTCT
CTAAATTCAGACAAACGTAGACCTATTCCCACTTTTTTCACATAGTAGTGCGCTGTTTCAGAGTTAAACAAACAAAAAAAAATAGCATGC
TTTAATGGTCTCCTAATTCATTCACCTGCAGTATCTGAACAAGGCGAGGCAGGTGCTGGGTGGGGGGATTCCTCCCATGAGAGGCTGCAT
CTCAGTACACAGCAGTGCAAGTCAAGCTGACCATAGAATTATCAAGTTAAAGAGAAGGAAGGCAATTGAGATCGGAACTCCAAGGATTAT
GGGAAACTTGGTGTTAAATGGGACAGAAAACATGAAAAAGCAATTTGGAGGCTCTGGCAACGAAGTCTGCTTGACTGCAACCTCATATCA
GGATTCCTGACTTTATGCTGCCTGTGTTTTTTCTAGACTGAAGATTTGAAAATACATCCACGAACATTTCAACATGGAACGAAGAATTAT
AGTTCCTTCTCTGGCTATATCCATAAAGAAGTAGTTATGAAATGTTTAAAACCAAAGGCAAATAGTGTTATACTCTTATTTTTTGATTAA
TCTGAGGAAAGGAGGTATTTAGAAACTGATGATGGTATCACTGCAAAAAGCATTCAACTTTTTTTTTTTGTTGAGATGGTGTTTCACTCT
GTCACCCAGGCTGGAGTGCAGTGGCGTGGTCTTGGCTCACTGCAACCTCTGCCTCACGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTG
ATTAGCTGGGATTACAGGTGCCCACCACCATGCCCAGCTAATTTTTTGTATTTTTGGTAGAGATGGGGTTTCACCATGTTGCCCAGGCTG
GTGTCAAACTCCTGACCTCGTGATCCACCTCCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCAGCATTC
AACTTTTGAGGGCTACCATATGAGCTGACAGCCTAGGGAAATAATCACTAGGACTGAAGTATCTACTCTGGGTTTAGAAATAACACCAAA
TTTTGTAGGATGCTATTATCTGGGAAAGGGAAGGCAGCAAGAAACCTACAAGGCACCAGGCTAGAATTCAGAGGGAAAGAAATCTCAATG
CAAAAAAATTACTGCAAAGAAATACAAGATAGTAGTCTCAAGACTAGGTAGAATTCCAAACTTTGAGCCGACGAATGCATGAGATTTCAG
TGGCCACCTGAGGAATCAGAGGGCAAACAATGGAACATTAAGTATTTTCAGCCCACTAGAAAGCTCTGTCTTCTATAAGCTTAAGAGTCC
GAGTGTCTTTACACCACTGAGTGCCATGCAGAGAAGGGTCATTTTCCTTGTATCTGGGGAGGCTGCTGCACCAGCTTAACATGTGGGTGT
GATTTGAAAGTTAGGTTTTCAGTTTGGATTCTTTCTGGATGAGCTGTTCTGTCTGCCCACACCTGTAGTGCTGAAATACAGAAAGACCTC

>96076_96076_1_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000392415_SLC9A7_chrX_46466638_ENST00000328306_length(amino acids)=147AA_BP=
MSWPRAGGRVHPQGEGRCGERARERAGTARARRASAARAPPPGKQRARASPPSFPRDNFTKMSSDRQRSDDESPSTSSGSSDADQRDPAA

--------------------------------------------------------------
>96076_96076_2_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000410062_SLC9A7_chrX_46466638_ENST00000328306_length(transcript)=2524nt_BP=638nt
GAACTTGCTGACTGCGCGGCCGGGAGGAGCCGAGCCGGGCGGCGGCGGCGGGAGGCTACAGCGCGCGGGGGTCTCCCGCGTCCCCTCCGC
CTCGCCGGGAGCTCGCGCCCTCGCCCAGCCGAGCTCCCACCCCCGCTTTTTTCCGAAGGCGCTGGGCGGCGCCACCCTCCGGCCGGAGCC
CGGCACTGCACAACCCCCTCCGACTTTCAATGTTCCACACTCCCCGGCCAGAGCCTCCTCGGCTTCTTTTTTTCCCTCCCCCCCCTTCCC
CCCCCCACAGCTGCCTCCATTTCCTTAAGGAAGGGTTTTTTTCTCTCTCCCTCCCCCACACCGTAGCGGCGCGCGAGCGGGCCGGGCGGG
CGGCCGAGTTTTCCAAGAGATAACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTGGCAGT
TCAGATGCGGACCAGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCCACCCAGCAGAAGAAAAACACC
AAACTCTCTAGCAAAACCACTGCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCT
AATTGCAGAACCAAGAGCCACTGAGAGAGGAAGACTCTGATTTCATCCTGACCGAAGGCGACCTGACATTGACCTACGGGGACAGCACAG
TGACTGCAAATGGCTCCTCAAGTTCGCACACCGCCTCCACGAGTCTGGAGGGCAGCCGGAGAACGAAGAGCAGCTCGGAGGAAGTGCTGG
AGCGAGACCTGGGAATGGGAGACCAGAAGGTTTCGAGCCGGGGCACCCGCCTAGTGTTTCCCCTGGAAGATAATGCTTGACTTTCCCCCC
AAGCCCTGGCGCGATGGGGTAGGCTCCCGATGGGGTGAGGACAGCTGCAAGCCCTAGTGTTGTTGGAGGTGGGGCAGTGACTAGATTGAA
CTAACTCTTCTATTTTATTGGGGTCTGAAGCTATTGTAACACTTAAAATTTAACTCACAATGCAGATGGTGAGGCAAAAGTGTCTCTAAA
TTCAGACAAACGTAGACCTATTCCCACTTTTTTCACATAGTAGTGCGCTGTTTCAGAGTTAAACAAACAAAAAAAAATAGCATGCTTTAA
TGGTCTCCTAATTCATTCACCTGCAGTATCTGAACAAGGCGAGGCAGGTGCTGGGTGGGGGGATTCCTCCCATGAGAGGCTGCATCTCAG
TACACAGCAGTGCAAGTCAAGCTGACCATAGAATTATCAAGTTAAAGAGAAGGAAGGCAATTGAGATCGGAACTCCAAGGATTATGGGAA
ACTTGGTGTTAAATGGGACAGAAAACATGAAAAAGCAATTTGGAGGCTCTGGCAACGAAGTCTGCTTGACTGCAACCTCATATCAGGATT
CCTGACTTTATGCTGCCTGTGTTTTTTCTAGACTGAAGATTTGAAAATACATCCACGAACATTTCAACATGGAACGAAGAATTATAGTTC
CTTCTCTGGCTATATCCATAAAGAAGTAGTTATGAAATGTTTAAAACCAAAGGCAAATAGTGTTATACTCTTATTTTTTGATTAATCTGA
GGAAAGGAGGTATTTAGAAACTGATGATGGTATCACTGCAAAAAGCATTCAACTTTTTTTTTTTGTTGAGATGGTGTTTCACTCTGTCAC
CCAGGCTGGAGTGCAGTGGCGTGGTCTTGGCTCACTGCAACCTCTGCCTCACGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGATTAG
CTGGGATTACAGGTGCCCACCACCATGCCCAGCTAATTTTTTGTATTTTTGGTAGAGATGGGGTTTCACCATGTTGCCCAGGCTGGTGTC
AAACTCCTGACCTCGTGATCCACCTCCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCAGCATTCAACTT
TTGAGGGCTACCATATGAGCTGACAGCCTAGGGAAATAATCACTAGGACTGAAGTATCTACTCTGGGTTTAGAAATAACACCAAATTTTG
TAGGATGCTATTATCTGGGAAAGGGAAGGCAGCAAGAAACCTACAAGGCACCAGGCTAGAATTCAGAGGGAAAGAAATCTCAATGCAAAA
AAATTACTGCAAAGAAATACAAGATAGTAGTCTCAAGACTAGGTAGAATTCCAAACTTTGAGCCGACGAATGCATGAGATTTCAGTGGCC
ACCTGAGGAATCAGAGGGCAAACAATGGAACATTAAGTATTTTCAGCCCACTAGAAAGCTCTGTCTTCTATAAGCTTAAGAGTCCGAGTG
TCTTTACACCACTGAGTGCCATGCAGAGAAGGGTCATTTTCCTTGTATCTGGGGAGGCTGCTGCACCAGCTTAACATGTGGGTGTGATTT
GAAAGTTAGGTTTTCAGTTTGGATTCTTTCTGGATGAGCTGTTCTGTCTGCCCACACCTGTAGTGCTGAAATACAGAAAGACCTCTCGGG

>96076_96076_2_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000410062_SLC9A7_chrX_46466638_ENST00000328306_length(amino acids)=123AA_BP=
MRGREEPSRAAAAGGYSARGSPASPPPRRELAPSPSRAPTPAFFRRRWAAPPSGRSPALHNPLRLSMFHTPRPEPPRLLFFPPPPSPPHS

--------------------------------------------------------------
>96076_96076_3_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000602475_SLC9A7_chrX_46466638_ENST00000328306_length(transcript)=2323nt_BP=437nt
GACTTTCAATGTTCCACACTCCCCGGCCAGAGCCTCCTCGGCTTCTTTTTTTCCCTCCCCCCCCTTCCCCCCCCCACAGCTGCCTCCATT
TCCTTAAGGAAGGGTTTTTTTCTCTCTCCCTCCCCCACACCGTAGCGGCGCGCGAGCGGGCCGGGCGGGCGGCCGAGTTTTCCAAGAGAT
AACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTGGCAGTTCAGATGCGGACCAGCGAGAC
CCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCCACCCAGCAGAAGAAAAACACCAAACTCTCTAGCAAAACCACT
GCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCTAATTGCAGAACCAAGAGCCAC
TGAGAGAGGAAGACTCTGATTTCATCCTGACCGAAGGCGACCTGACATTGACCTACGGGGACAGCACAGTGACTGCAAATGGCTCCTCAA
GTTCGCACACCGCCTCCACGAGTCTGGAGGGCAGCCGGAGAACGAAGAGCAGCTCGGAGGAAGTGCTGGAGCGAGACCTGGGAATGGGAG
ACCAGAAGGTTTCGAGCCGGGGCACCCGCCTAGTGTTTCCCCTGGAAGATAATGCTTGACTTTCCCCCCAAGCCCTGGCGCGATGGGGTA
GGCTCCCGATGGGGTGAGGACAGCTGCAAGCCCTAGTGTTGTTGGAGGTGGGGCAGTGACTAGATTGAACTAACTCTTCTATTTTATTGG
GGTCTGAAGCTATTGTAACACTTAAAATTTAACTCACAATGCAGATGGTGAGGCAAAAGTGTCTCTAAATTCAGACAAACGTAGACCTAT
TCCCACTTTTTTCACATAGTAGTGCGCTGTTTCAGAGTTAAACAAACAAAAAAAAATAGCATGCTTTAATGGTCTCCTAATTCATTCACC
TGCAGTATCTGAACAAGGCGAGGCAGGTGCTGGGTGGGGGGATTCCTCCCATGAGAGGCTGCATCTCAGTACACAGCAGTGCAAGTCAAG
CTGACCATAGAATTATCAAGTTAAAGAGAAGGAAGGCAATTGAGATCGGAACTCCAAGGATTATGGGAAACTTGGTGTTAAATGGGACAG
AAAACATGAAAAAGCAATTTGGAGGCTCTGGCAACGAAGTCTGCTTGACTGCAACCTCATATCAGGATTCCTGACTTTATGCTGCCTGTG
TTTTTTCTAGACTGAAGATTTGAAAATACATCCACGAACATTTCAACATGGAACGAAGAATTATAGTTCCTTCTCTGGCTATATCCATAA
AGAAGTAGTTATGAAATGTTTAAAACCAAAGGCAAATAGTGTTATACTCTTATTTTTTGATTAATCTGAGGAAAGGAGGTATTTAGAAAC
TGATGATGGTATCACTGCAAAAAGCATTCAACTTTTTTTTTTTGTTGAGATGGTGTTTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCG
TGGTCTTGGCTCACTGCAACCTCTGCCTCACGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGATTAGCTGGGATTACAGGTGCCCACC
ACCATGCCCAGCTAATTTTTTGTATTTTTGGTAGAGATGGGGTTTCACCATGTTGCCCAGGCTGGTGTCAAACTCCTGACCTCGTGATCC
ACCTCCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCAGCATTCAACTTTTGAGGGCTACCATATGAGCT
GACAGCCTAGGGAAATAATCACTAGGACTGAAGTATCTACTCTGGGTTTAGAAATAACACCAAATTTTGTAGGATGCTATTATCTGGGAA
AGGGAAGGCAGCAAGAAACCTACAAGGCACCAGGCTAGAATTCAGAGGGAAAGAAATCTCAATGCAAAAAAATTACTGCAAAGAAATACA
AGATAGTAGTCTCAAGACTAGGTAGAATTCCAAACTTTGAGCCGACGAATGCATGAGATTTCAGTGGCCACCTGAGGAATCAGAGGGCAA
ACAATGGAACATTAAGTATTTTCAGCCCACTAGAAAGCTCTGTCTTCTATAAGCTTAAGAGTCCGAGTGTCTTTACACCACTGAGTGCCA
TGCAGAGAAGGGTCATTTTCCTTGTATCTGGGGAGGCTGCTGCACCAGCTTAACATGTGGGTGTGATTTGAAAGTTAGGTTTTCAGTTTG

>96076_96076_3_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000602475_SLC9A7_chrX_46466638_ENST00000328306_length(amino acids)=86AA_BP=

--------------------------------------------------------------
>96076_96076_4_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000602632_SLC9A7_chrX_46466638_ENST00000328306_length(transcript)=2151nt_BP=265nt
CAAGAGATAACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTGGCAGTTCAGATGCGGACC
AGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCCACCCAGCAGAAGAAAAACACCAAACTCTCTAGCA
AAACCACTGCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCTAATTGCAGAACCA
AGAGCCACTGAGAGAGGAAGACTCTGATTTCATCCTGACCGAAGGCGACCTGACATTGACCTACGGGGACAGCACAGTGACTGCAAATGG
CTCCTCAAGTTCGCACACCGCCTCCACGAGTCTGGAGGGCAGCCGGAGAACGAAGAGCAGCTCGGAGGAAGTGCTGGAGCGAGACCTGGG
AATGGGAGACCAGAAGGTTTCGAGCCGGGGCACCCGCCTAGTGTTTCCCCTGGAAGATAATGCTTGACTTTCCCCCCAAGCCCTGGCGCG
ATGGGGTAGGCTCCCGATGGGGTGAGGACAGCTGCAAGCCCTAGTGTTGTTGGAGGTGGGGCAGTGACTAGATTGAACTAACTCTTCTAT
TTTATTGGGGTCTGAAGCTATTGTAACACTTAAAATTTAACTCACAATGCAGATGGTGAGGCAAAAGTGTCTCTAAATTCAGACAAACGT
AGACCTATTCCCACTTTTTTCACATAGTAGTGCGCTGTTTCAGAGTTAAACAAACAAAAAAAAATAGCATGCTTTAATGGTCTCCTAATT
CATTCACCTGCAGTATCTGAACAAGGCGAGGCAGGTGCTGGGTGGGGGGATTCCTCCCATGAGAGGCTGCATCTCAGTACACAGCAGTGC
AAGTCAAGCTGACCATAGAATTATCAAGTTAAAGAGAAGGAAGGCAATTGAGATCGGAACTCCAAGGATTATGGGAAACTTGGTGTTAAA
TGGGACAGAAAACATGAAAAAGCAATTTGGAGGCTCTGGCAACGAAGTCTGCTTGACTGCAACCTCATATCAGGATTCCTGACTTTATGC
TGCCTGTGTTTTTTCTAGACTGAAGATTTGAAAATACATCCACGAACATTTCAACATGGAACGAAGAATTATAGTTCCTTCTCTGGCTAT
ATCCATAAAGAAGTAGTTATGAAATGTTTAAAACCAAAGGCAAATAGTGTTATACTCTTATTTTTTGATTAATCTGAGGAAAGGAGGTAT
TTAGAAACTGATGATGGTATCACTGCAAAAAGCATTCAACTTTTTTTTTTTGTTGAGATGGTGTTTCACTCTGTCACCCAGGCTGGAGTG
CAGTGGCGTGGTCTTGGCTCACTGCAACCTCTGCCTCACGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGATTAGCTGGGATTACAGG
TGCCCACCACCATGCCCAGCTAATTTTTTGTATTTTTGGTAGAGATGGGGTTTCACCATGTTGCCCAGGCTGGTGTCAAACTCCTGACCT
CGTGATCCACCTCCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCAGCATTCAACTTTTGAGGGCTACCA
TATGAGCTGACAGCCTAGGGAAATAATCACTAGGACTGAAGTATCTACTCTGGGTTTAGAAATAACACCAAATTTTGTAGGATGCTATTA
TCTGGGAAAGGGAAGGCAGCAAGAAACCTACAAGGCACCAGGCTAGAATTCAGAGGGAAAGAAATCTCAATGCAAAAAAATTACTGCAAA
GAAATACAAGATAGTAGTCTCAAGACTAGGTAGAATTCCAAACTTTGAGCCGACGAATGCATGAGATTTCAGTGGCCACCTGAGGAATCA
GAGGGCAAACAATGGAACATTAAGTATTTTCAGCCCACTAGAAAGCTCTGTCTTCTATAAGCTTAAGAGTCCGAGTGTCTTTACACCACT
GAGTGCCATGCAGAGAAGGGTCATTTTCCTTGTATCTGGGGAGGCTGCTGCACCAGCTTAACATGTGGGTGTGATTTGAAAGTTAGGTTT

>96076_96076_4_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000602632_SLC9A7_chrX_46466638_ENST00000328306_length(amino acids)=86AA_BP=

--------------------------------------------------------------
>96076_96076_5_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000602710_SLC9A7_chrX_46466638_ENST00000328306_length(transcript)=2510nt_BP=624nt
TCACTTGGCGCCCGGCGCGGCGAGCGCTACCCGCGGCCCCCGCGCGGCCCTCCCCACAAAGGGCCGCGGAGCTGCGTGGCCGCCGCCGCC
GGCCGTGGCTCGCCTCCGCGGGCGCGGAAATTTGTTGCACTTCTTGGGGCTTTGTTTATTTGTTTGTTTTTTCTCTGGGTTTCTTATTTT
TTTCGTTATTTTGGACAAAATGTCGGTCCGTGATATAAAAATTGAGCGAGGAACCTTGGTGGCATTGGGAGCTTTGCAGAAGGTGCAGTT
TGAATTCTGCTTTTCCCAGGGTGGCAGCTCGGTCTTGGCCGGATGAATCTTCGCTGCTGGCCGTGGAAACAGCTAGAGCAGCTCTTTTCC
AAGAGATAACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGCCCCAGCACCAGCAGTGGCAGTTCAGATGCGGACCA
GCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCCACCCAGCAGAAGAAAAACACCAAACTCTCTAGCAA
AACCACTGCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAAATAACCCTTGATCCTCCTCCTAATTGCAGAACCAA
GAGCCACTGAGAGAGGAAGACTCTGATTTCATCCTGACCGAAGGCGACCTGACATTGACCTACGGGGACAGCACAGTGACTGCAAATGGC
TCCTCAAGTTCGCACACCGCCTCCACGAGTCTGGAGGGCAGCCGGAGAACGAAGAGCAGCTCGGAGGAAGTGCTGGAGCGAGACCTGGGA
ATGGGAGACCAGAAGGTTTCGAGCCGGGGCACCCGCCTAGTGTTTCCCCTGGAAGATAATGCTTGACTTTCCCCCCAAGCCCTGGCGCGA
TGGGGTAGGCTCCCGATGGGGTGAGGACAGCTGCAAGCCCTAGTGTTGTTGGAGGTGGGGCAGTGACTAGATTGAACTAACTCTTCTATT
TTATTGGGGTCTGAAGCTATTGTAACACTTAAAATTTAACTCACAATGCAGATGGTGAGGCAAAAGTGTCTCTAAATTCAGACAAACGTA
GACCTATTCCCACTTTTTTCACATAGTAGTGCGCTGTTTCAGAGTTAAACAAACAAAAAAAAATAGCATGCTTTAATGGTCTCCTAATTC
ATTCACCTGCAGTATCTGAACAAGGCGAGGCAGGTGCTGGGTGGGGGGATTCCTCCCATGAGAGGCTGCATCTCAGTACACAGCAGTGCA
AGTCAAGCTGACCATAGAATTATCAAGTTAAAGAGAAGGAAGGCAATTGAGATCGGAACTCCAAGGATTATGGGAAACTTGGTGTTAAAT
GGGACAGAAAACATGAAAAAGCAATTTGGAGGCTCTGGCAACGAAGTCTGCTTGACTGCAACCTCATATCAGGATTCCTGACTTTATGCT
GCCTGTGTTTTTTCTAGACTGAAGATTTGAAAATACATCCACGAACATTTCAACATGGAACGAAGAATTATAGTTCCTTCTCTGGCTATA
TCCATAAAGAAGTAGTTATGAAATGTTTAAAACCAAAGGCAAATAGTGTTATACTCTTATTTTTTGATTAATCTGAGGAAAGGAGGTATT
TAGAAACTGATGATGGTATCACTGCAAAAAGCATTCAACTTTTTTTTTTTGTTGAGATGGTGTTTCACTCTGTCACCCAGGCTGGAGTGC
AGTGGCGTGGTCTTGGCTCACTGCAACCTCTGCCTCACGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTGATTAGCTGGGATTACAGGT
GCCCACCACCATGCCCAGCTAATTTTTTGTATTTTTGGTAGAGATGGGGTTTCACCATGTTGCCCAGGCTGGTGTCAAACTCCTGACCTC
GTGATCCACCTCCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCAGCATTCAACTTTTGAGGGCTACCAT
ATGAGCTGACAGCCTAGGGAAATAATCACTAGGACTGAAGTATCTACTCTGGGTTTAGAAATAACACCAAATTTTGTAGGATGCTATTAT
CTGGGAAAGGGAAGGCAGCAAGAAACCTACAAGGCACCAGGCTAGAATTCAGAGGGAAAGAAATCTCAATGCAAAAAAATTACTGCAAAG
AAATACAAGATAGTAGTCTCAAGACTAGGTAGAATTCCAAACTTTGAGCCGACGAATGCATGAGATTTCAGTGGCCACCTGAGGAATCAG
AGGGCAAACAATGGAACATTAAGTATTTTCAGCCCACTAGAAAGCTCTGTCTTCTATAAGCTTAAGAGTCCGAGTGTCTTTACACCACTG
AGTGCCATGCAGAGAAGGGTCATTTTCCTTGTATCTGGGGAGGCTGCTGCACCAGCTTAACATGTGGGTGTGATTTGAAAGTTAGGTTTT

>96076_96076_5_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000602710_SLC9A7_chrX_46466638_ENST00000328306_length(amino acids)=122AA_BP=
MSEEPWWHWELCRRCSLNSAFPRVAARSWPDESSLLAVETARAALFQEITSPRCPVIGKGPMMRAPAPAVAVQMRTSETQPLQSLKNKRK

--------------------------------------------------------------
>96076_96076_6_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000602959_SLC9A7_chrX_46466638_ENST00000328306_length(transcript)=2275nt_BP=389nt
CGGCCAAGGGCGGCAGGGGCCAGCCCGCCGGGTCCCCGCCGCGCTCTTTGTCCTGGCCGCGCGCGGGCGGACGCGTGCACCCCCAGGCGG
CGCGCGAGCGGGCCGGGCGGGCGGCCGAGTTTTCCAAGAGATAACTTCACCAAGATGTCCAGTGATAGGCAAAGGTCCGATGATGAGAGC
CCCAGCACCAGCAGTGGCAGTTCAGATGCGGACCAGCGAGACCCAGCCGCTCCAGAGCCTGAAGAACAAGAGGAAAGAAAACCTTCTGCC
ACCCAGCAGAAGAAAAACACCAAACTCTCTAGCAAAACCACTGCTAAGTTATCCACTAGTGCTAAAAGAATTCAGAAGGAGCTAGCTGAA
ATAACCCTTGATCCTCCTCCTAATTGCAGAACCAAGAGCCACTGAGAGAGGAAGACTCTGATTTCATCCTGACCGAAGGCGACCTGACAT
TGACCTACGGGGACAGCACAGTGACTGCAAATGGCTCCTCAAGTTCGCACACCGCCTCCACGAGTCTGGAGGGCAGCCGGAGAACGAAGA
GCAGCTCGGAGGAAGTGCTGGAGCGAGACCTGGGAATGGGAGACCAGAAGGTTTCGAGCCGGGGCACCCGCCTAGTGTTTCCCCTGGAAG
ATAATGCTTGACTTTCCCCCCAAGCCCTGGCGCGATGGGGTAGGCTCCCGATGGGGTGAGGACAGCTGCAAGCCCTAGTGTTGTTGGAGG
TGGGGCAGTGACTAGATTGAACTAACTCTTCTATTTTATTGGGGTCTGAAGCTATTGTAACACTTAAAATTTAACTCACAATGCAGATGG
TGAGGCAAAAGTGTCTCTAAATTCAGACAAACGTAGACCTATTCCCACTTTTTTCACATAGTAGTGCGCTGTTTCAGAGTTAAACAAACA
AAAAAAAATAGCATGCTTTAATGGTCTCCTAATTCATTCACCTGCAGTATCTGAACAAGGCGAGGCAGGTGCTGGGTGGGGGGATTCCTC
CCATGAGAGGCTGCATCTCAGTACACAGCAGTGCAAGTCAAGCTGACCATAGAATTATCAAGTTAAAGAGAAGGAAGGCAATTGAGATCG
GAACTCCAAGGATTATGGGAAACTTGGTGTTAAATGGGACAGAAAACATGAAAAAGCAATTTGGAGGCTCTGGCAACGAAGTCTGCTTGA
CTGCAACCTCATATCAGGATTCCTGACTTTATGCTGCCTGTGTTTTTTCTAGACTGAAGATTTGAAAATACATCCACGAACATTTCAACA
TGGAACGAAGAATTATAGTTCCTTCTCTGGCTATATCCATAAAGAAGTAGTTATGAAATGTTTAAAACCAAAGGCAAATAGTGTTATACT
CTTATTTTTTGATTAATCTGAGGAAAGGAGGTATTTAGAAACTGATGATGGTATCACTGCAAAAAGCATTCAACTTTTTTTTTTTGTTGA
GATGGTGTTTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGGTCTTGGCTCACTGCAACCTCTGCCTCACGGGTTCAAGTGATTCTC
CTGCCTCAGCCTCCTGATTAGCTGGGATTACAGGTGCCCACCACCATGCCCAGCTAATTTTTTGTATTTTTGGTAGAGATGGGGTTTCAC
CATGTTGCCCAGGCTGGTGTCAAACTCCTGACCTCGTGATCCACCTCCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTG
CACCTGGCCAGCATTCAACTTTTGAGGGCTACCATATGAGCTGACAGCCTAGGGAAATAATCACTAGGACTGAAGTATCTACTCTGGGTT
TAGAAATAACACCAAATTTTGTAGGATGCTATTATCTGGGAAAGGGAAGGCAGCAAGAAACCTACAAGGCACCAGGCTAGAATTCAGAGG
GAAAGAAATCTCAATGCAAAAAAATTACTGCAAAGAAATACAAGATAGTAGTCTCAAGACTAGGTAGAATTCCAAACTTTGAGCCGACGA
ATGCATGAGATTTCAGTGGCCACCTGAGGAATCAGAGGGCAAACAATGGAACATTAAGTATTTTCAGCCCACTAGAAAGCTCTGTCTTCT
ATAAGCTTAAGAGTCCGAGTGTCTTTACACCACTGAGTGCCATGCAGAGAAGGGTCATTTTCCTTGTATCTGGGGAGGCTGCTGCACCAG
CTTAACATGTGGGTGTGATTTGAAAGTTAGGTTTTCAGTTTGGATTCTTTCTGGATGAGCTGTTCTGTCTGCCCACACCTGTAGTGCTGA

>96076_96076_6_UBE2E3-SLC9A7_UBE2E3_chr2_181848820_ENST00000602959_SLC9A7_chrX_46466638_ENST00000328306_length(amino acids)=100AA_BP=
MAARGRTRAPPGGARAGRAGGRVFQEITSPRCPVIGKGPMMRAPAPAVAVQMRTSETQPLQSLKNKRKENLLPPSRRKTPNSLAKPLLSY

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UBE2E3-SLC9A7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for UBE2E3-SLC9A7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for UBE2E3-SLC9A7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source