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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UBE2G1-GABPB2 (FusionGDB2 ID:96093)

Fusion Gene Summary for UBE2G1-GABPB2

Fusion gene summary

Fusion gene information	Fusion gene name: UBE2G1-GABPB2
	Fusion gene ID: 96093
		Hgene	Tgene
	Gene symbol	UBE2G1	GABPB2
	Gene ID	7326	126626
	Gene name	ubiquitin conjugating enzyme E2 G1	GA binding protein transcription factor subunit beta 2
	Synonyms	E217K\|UBC7\|UBE2G	GABPB-2
	Cytomap	17p13.2	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin-conjugating enzyme E2 G1E2 ubiquitin-conjugating enzyme G1ubiquitin carrier protein G1ubiquitin conjugating enzyme E2G 1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)ub	GA-binding protein subunit beta-2GA binding protein transcription factor beta subunit 2GABP subunit beta-2
	Modification date	20200313	20200313
	UniProtAcc	.	Q8TAK5
	Ensembl transtripts involved in fusion gene	ENST00000396981, ENST00000572484,	ENST00000467551, ENST00000368916, ENST00000368917, ENST00000368918,
Fusion gene scores	* DoF score	18 X 9 X 10=1620	5 X 4 X 4=80
	# samples	27	5
	** MAII score	log2(27/1620*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UBE2G1 [Title/Abstract] AND GABPB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UBE2G1(4269566)-GABPB2(151060666), # samples:1
Anticipated loss of major functional domain due to fusion event.	UBE2G1-GABPB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBE2G1	GO:0070534	protein K63-linked ubiquitination	20061386
Hgene	UBE2G1	GO:0070936	protein K48-linked ubiquitination	14593114\|20061386
Tgene	GABPB2	GO:0045944	positive regulation of transcription by RNA polymerase II	9857059

Fusion gene breakpoints across UBE2G1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GABPB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GJ-01A	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+

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Fusion Gene ORF analysis for UBE2G1-GABPB2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000396981	ENST00000467551	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+
5UTR-3CDS	ENST00000572484	ENST00000368916	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+
5UTR-3CDS	ENST00000572484	ENST00000368917	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+
5UTR-3CDS	ENST00000572484	ENST00000368918	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+
5UTR-intron	ENST00000572484	ENST00000467551	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+
Frame-shift	ENST00000396981	ENST00000368916	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+
In-frame	ENST00000396981	ENST00000368917	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+
In-frame	ENST00000396981	ENST00000368918	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000396981

UBE2G1

chr17

4269566

ENST00000368917

GABPB2

chr1

151060666

3109

212

1444

410

ENST00000396981

UBE2G1

chr17

4269566

ENST00000368918

GABPB2

chr1

151060666

8845

212

1558

448

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000396981	ENST00000368917	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+	0.001039719	0.99896026
ENST00000396981	ENST00000368918	UBE2G1	chr17	4269566	-	GABPB2	chr1	151060666	+	0.000451931	0.999548

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Fusion Genomic Features for UBE2G1-GABPB2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
UBE2G1	chr17	4269565	-	GABPB2	chr1	151060665	+	5.60E-09	1
UBE2G1	chr17	4269565	-	GABPB2	chr1	151060665	+	5.60E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBE2G1-GABPB2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:4269566/chr1:151060666)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GABPB2 Q8TAK5
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May function as transcription factor capable of interacting with purine rich repeats (GA repeats). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GABPB2

chr17:4269566

chr1:151060666

ENST00000368918

345_395

449.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GABPB2

chr17:4269566

chr1:151060666

ENST00000368918

103_132

449.0

Repeat

Note=ANK 4

Tgene

GABPB2

chr17:4269566

chr1:151060666

ENST00000368918

136_166

449.0

Repeat

Note=ANK 5

Tgene

GABPB2

chr17:4269566

chr1:151060666

ENST00000368918

37_66

449.0

Repeat

Note=ANK 2

Tgene

GABPB2

chr17:4269566

chr1:151060666

ENST00000368918

5_34

449.0

Repeat

Note=ANK 1

Tgene

GABPB2

chr17:4269566

chr1:151060666

ENST00000368918

70_99

449.0

Repeat

Note=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBE2G1

chr17:4269566

chr1:151060666

ENST00000396981

5_166

1193.3333333333333

Domain

UBC core

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Fusion Gene Sequence for UBE2G1-GABPB2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>96093_96093_1_UBE2G1-GABPB2_UBE2G1_chr17_4269566_ENST00000396981_GABPB2_chr1_151060666_ENST00000368917_length(transcript)=3109nt_BP=212nt
ACCGGCAGCGAGGCGCCGCTCCCGCCGCCTCAGCCCGGCCTTCCTCGGCTCCGGCGCTCCGGTCGCGGGGCCCGGGTTCCTCGGCACACC
CCGCTCCAGCCGCCCCCAGAGCCTGTCCCCAGCCCTTCGGAAGCCCCGGCGCCAGCCCGGGCCCTCGGCAGGGAGGATGACGGAGCTGCA
GTCGGCACTGCTACTGCGAAGACAGCTGGCAGATGTCTTTGGTGGACTTGGGAAAGAGGTTGCTAGAAGCAGCAAGAAAAGGCCAAGATG
ATGAAGTGAGAACGTTGATGGCAAATGGCGCCCCATTCACCACAGACTGGCTTGGAACATCACCCCTCCACCTTGCAGCTCAATATGGTC
ATTATTCCACAGCAGAAGTACTCCTTCGAGCAGGTGTTAGCAGGGATGCCCGGACTAAAGTAGACAGGACCCCCTTGCACATGGCTGCAG
CCGATGGACATGCGCACATCGTGGAACTGCTTGTTCGGAATGGTGCAGATGTGAATGCCAAGGACATGCTGAAGATGACAGCTTTGCATT
GGGCCACAGAGCGCCACCATCGAGATGTCGTAGAGTTACTTATCAAATATGGAGCTGATGTCCATGCTTTCAGCAAATTTGATAAATCAG
CCTTTGACATAGCTCTGGAGAAAAACAATGCTGAGATTTTGGTCATCCTCCAGGAAGCAATGCAGAATCAGGTGAATGTTAATCCAGAGA
GAGCCAACCCTGTGACTGACCCTGTGAGTATGGCTGCTCCATTCATCTTCACGTCGGGTGAGGTTGTTAACCTCGCAAGCCTTATTTCTT
CAACCAACACCAAAACAACCTCAGCCAATACAGAGGAAATTATAGAAGGAAATTCCGTTGACTCATCAATCCAGCAAGTAATGGGGAGTG
GAGGCCAGAGGGTCATCACCATAGTGACTGATGGAGTCCCTCTGGGTAATATCCAAACTTCAATCCCTACTGGAGGCATTGGCCAGCCAT
TTATTGTAACTGTGCAAGATGGACAGCAAGTTCTAACTGTACCTGCTGGTAAGGTTGCAGAGGAGACTGTAATTAAAGAGGAAGAAGAAG
AGAAGTTGCCACTAACAAAGAAACCAAGGATAGGAGAGAAGACAAACAGTGTGGAGGAAAGCAAGGAAGGCAATGAAAGAGAGCTACTAC
AGCAACAACTCCAGGAGGCCAATCGAAGAGCCCAGGAATACCGACACCAGCTCCTAAAGAAAGAGCAGGAAGCAGAACAGTACCGTCTTA
AGCTGGAGGCCATAGCCCGACAGCAGCCCAATGGAGTTGATTTCACCATGGTTGAAGAGGTGGCTGAGGTAGATGCTGTAGTAGTCACAG
AGGGGGAGTTGGAAGAGAGAGAGACAAAAGTGACTGGGTCAGCAGGGACCACAGAGCCTCACACTAGAGTTTCCATGGCAACTGTTTCAT
CTTAATATGCAAGGGCCACAATTTGCACTGTGTTCATATTAATCCTCTTTTAAAAAAGGAAATATACAGAAGACAAACATTGTATAAAAA
CTAAGAGTGTCTTTAAGAAGAAAACTATAGCAGGGTACAATGCTTGGGCTCAGGAAGTTTCTCTGTGCAACTAGAAAATTCAAAGCCATA
TTTAGGGAACATTTTTTCTGAGGGGCCAAAAGAATAAAGGACCAAATTTCTTAGCTCATATCATTGCTTTAAACATAGAAGTAAAAGAAT
ACTGCATGTTGTGGGTTGATTTTTTTTTTTTAAATAACTGACTTTCTCACAAAAGATTTTAAGATAACATTTCTAATATATATGCACCAA
TATATATGCCTTTAATAATTATACCATCAAGTGACCTGAAAATGCCCCTTAGATTTATGATGCGTATCTGTTGGAAAAACCAATTGGAAG
GGAAGTTAGACAAGCTTTGGGGAAGAGAAAAGGAATATAGTCCATTTCCAAAGGAGCAGGAACTCCCAACCTTAAGTTAATTTCACTGAA
GAGAATTTTCCCTTTTTTTTTTTTTTTTTGAGACACGGTCTGACTCTGTCACCCAGGCTAGAGTACAGTGGTGCAATCTTGGCTCACTGC
AACCTCCGCCTCCAGGGCGCAGCCTCCTGAGTAGCTGGGAGGACAGGCATATGCCACCACATCACTGAGAAGAAATTTTTGATTGTCTGA
CAGATACTTATCCATTATGTGTCTATAGTTCAGATGCTTGTGTAAGAAACTGAAATAAGCTGCGTGTGGTGGCTCACACCTGTAATCCCA
ACACTTTGGGACGTTGAAATGGGAGAATTGCTTGAGTCCAGGAGTTTGAGATGCGCCTGGGCAACATAGAAACCTGTGTCTACAAAAAAT
TTAAAAATTAGCCAAGTATGGTGACAGGCACCTATGGTTCCAGCTACTCAGGAGGCTGAGGTGGGAGGATCGCTTGTGCCTTGGAGGTCA
AAACTGCAGTGAGCCATGGTTGCACCACTGCTCTCCAGGCTTGAGTGACAGAGCAAGACTGTATCTCAAAGGAAAAAGGAAACTAGGCCA
GGCGTGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGATCAAGAACATCCTGGCTAACAC
GGTGAAACTCCATCTCTACTAAAAATACAAAAAATTGGCCGGGCGCAGCGGCTCACGCCTGTAATCCCAGCACTTTCGGAGGCAGAGGCA
GGCGGATCACAAGGTCAAGAGATTAAGATCATCCTGGCCAACATGGTGACACCCCGTCTCTACTAAAAATACAAAAATTACCCAGGCATA
GTGGCACACGCCTGTAGTCCCAGTTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCAAGAT
CGTGCCACTGCACTCCAGCCTGGCGACACAGTGAGACTCTGTCTCAAAAAAACAAAACAAACAAACAAAAATACAAAAAATTAGCCGGGC
GTGGTGGCACCTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGA

>96093_96093_1_UBE2G1-GABPB2_UBE2G1_chr17_4269566_ENST00000396981_GABPB2_chr1_151060666_ENST00000368917_length(amino acids)=410AA_BP=0
MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELL
VRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM
AAPFIFTSGEVVNLASLISSTNTKTTSANTEEIIEGNSVDSSIQQVMGSGGQRVITIVTDGVPLGNIQTSIPTGGIGQPFIVTVQDGQQV
LTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPN

--------------------------------------------------------------
>96093_96093_2_UBE2G1-GABPB2_UBE2G1_chr17_4269566_ENST00000396981_GABPB2_chr1_151060666_ENST00000368918_length(transcript)=8845nt_BP=212nt
ACCGGCAGCGAGGCGCCGCTCCCGCCGCCTCAGCCCGGCCTTCCTCGGCTCCGGCGCTCCGGTCGCGGGGCCCGGGTTCCTCGGCACACC
CCGCTCCAGCCGCCCCCAGAGCCTGTCCCCAGCCCTTCGGAAGCCCCGGCGCCAGCCCGGGCCCTCGGCAGGGAGGATGACGGAGCTGCA
GTCGGCACTGCTACTGCGAAGACAGCTGGCAGATGTCTTTGGTGGACTTGGGAAAGAGGTTGCTAGAAGCAGCAAGAAAAGGCCAAGATG
ATGAAGTGAGAACGTTGATGGCAAATGGCGCCCCATTCACCACAGACTGGCTTGGAACATCACCCCTCCACCTTGCAGCTCAATATGGTC
ATTATTCCACAGCAGAAGTACTCCTTCGAGCAGGTGTTAGCAGGGATGCCCGGACTAAAGTAGACAGGACCCCCTTGCACATGGCTGCAG
CCGATGGACATGCGCACATCGTGGAACTGCTTGTTCGGAATGGTGCAGATGTGAATGCCAAGGACATGCTGAAGATGACAGCTTTGCATT
GGGCCACAGAGCGCCACCATCGAGATGTCGTAGAGTTACTTATCAAATATGGAGCTGATGTCCATGCTTTCAGCAAATTTGATAAATCAG
CCTTTGACATAGCTCTGGAGAAAAACAATGCTGAGATTTTGGTCATCCTCCAGGAAGCAATGCAGAATCAGGTGAATGTTAATCCAGAGA
GAGCCAACCCTGTGACTGACCCTGTGAGTATGGCTGCTCCATTCATCTTCACGTCGGGTGAGGTTGTTAACCTCGCAAGCCTTATTTCTT
CAACCAACACCAAAACAACCTCAGGTGACCCCCATGCCTCAACAGTACAGTTTTCAAATTCTACCACCTCAGTGCTGGCTACCCTTGCAG
CTCTTGCTGAGGCATCAGTCCCCCTCTCCAACTCACACAGAGCCACAGCCAATACAGAGGAAATTATAGAAGGAAATTCCGTTGACTCAT
CAATCCAGCAAGTAATGGGGAGTGGAGGCCAGAGGGTCATCACCATAGTGACTGATGGAGTCCCTCTGGGTAATATCCAAACTTCAATCC
CTACTGGAGGCATTGGCCAGCCATTTATTGTAACTGTGCAAGATGGACAGCAAGTTCTAACTGTACCTGCTGGTAAGGTTGCAGAGGAGA
CTGTAATTAAAGAGGAAGAAGAAGAGAAGTTGCCACTAACAAAGAAACCAAGGATAGGAGAGAAGACAAACAGTGTGGAGGAAAGCAAGG
AAGGCAATGAAAGAGAGCTACTACAGCAACAACTCCAGGAGGCCAATCGAAGAGCCCAGGAATACCGACACCAGCTCCTAAAGAAAGAGC
AGGAAGCAGAACAGTACCGTCTTAAGCTGGAGGCCATAGCCCGACAGCAGCCCAATGGAGTTGATTTCACCATGGTTGAAGAGGTGGCTG
AGGTAGATGCTGTAGTAGTCACAGAGGGGGAGTTGGAAGAGAGAGAGACAAAAGTGACTGGGTCAGCAGGGACCACAGAGCCTCACACTA
GAGTTTCCATGGCAACTGTTTCATCTTAATATGCAAGGGCCACAATTTGCACTGTGTTCATATTAATCCTCTTTTAAAAAAGGAAATATA
CAGAAGACAAACATTGTATAAAAACTAAGAGTGTCTTTAAGAAGAAAACTATAGCAGGGTACAATGCTTGGGCTCAGGAAGTTTCTCTGT
GCAACTAGAAAATTCAAAGCCATATTTAGGGAACATTTTTTCTGAGGGGCCAAAAGAATAAAGGACCAAATTTCTTAGCTCATATCATTG
CTTTAAACATAGAAGTAAAAGAATACTGCATGTTGTGGGTTGATTTTTTTTTTTTAAATAACTGACTTTCTCACAAAAGATTTTAAGATA
ACATTTCTAATATATATGCACCAATATATATGCCTTTAATAATTATACCATCAAGTGACCTGAAAATGCCCCTTAGATTTATGATGCGTA
TCTGTTGGAAAAACCAATTGGAAGGGAAGTTAGACAAGCTTTGGGGAAGAGAAAAGGAATATAGTCCATTTCCAAAGGAGCAGGAACTCC
CAACCTTAAGTTAATTTCACTGAAGAGAATTTTCCCTTTTTTTTTTTTTTTTTGAGACACGGTCTGACTCTGTCACCCAGGCTAGAGTAC
AGTGGTGCAATCTTGGCTCACTGCAACCTCCGCCTCCAGGGCGCAGCCTCCTGAGTAGCTGGGAGGACAGGCATATGCCACCACATCACT
GAGAAGAAATTTTTGATTGTCTGACAGATACTTATCCATTATGTGTCTATAGTTCAGATGCTTGTGTAAGAAACTGAAATAAGCTGCGTG
TGGTGGCTCACACCTGTAATCCCAACACTTTGGGACGTTGAAATGGGAGAATTGCTTGAGTCCAGGAGTTTGAGATGCGCCTGGGCAACA
TAGAAACCTGTGTCTACAAAAAATTTAAAAATTAGCCAAGTATGGTGACAGGCACCTATGGTTCCAGCTACTCAGGAGGCTGAGGTGGGA
GGATCGCTTGTGCCTTGGAGGTCAAAACTGCAGTGAGCCATGGTTGCACCACTGCTCTCCAGGCTTGAGTGACAGAGCAAGACTGTATCT
CAAAGGAAAAAGGAAACTAGGCCAGGCGTGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCA
GATCAAGAACATCCTGGCTAACACGGTGAAACTCCATCTCTACTAAAAATACAAAAAATTGGCCGGGCGCAGCGGCTCACGCCTGTAATC
CCAGCACTTTCGGAGGCAGAGGCAGGCGGATCACAAGGTCAAGAGATTAAGATCATCCTGGCCAACATGGTGACACCCCGTCTCTACTAA
AAATACAAAAATTACCCAGGCATAGTGGCACACGCCTGTAGTCCCAGTTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAG
GTGGAGGTTGCAGTGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGCGACACAGTGAGACTCTGTCTCAAAAAAACAAAACAAACAAAC
AAAAATACAAAAAATTAGCCGGGCGTGGTGGCACCTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGG
GAGGCGGAGGTTGCAGTGAGCTGAGATCGCACCATTACACTCCAGCCTGGGCAACAGAGCCAGACTCTGTCTCAAAAAAAAAAAAAAAGG
AAATTGAAATAGAGTTTTTAAAAACTGAACTGGAAAGCCGAGGCGAGCGGATCACCTGAGGCCAGGAGTTCCAGACCAGCCTGACCAACA
TGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGGGCCAGACCCGGCAGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGT
GGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGGCCGAGATGGTGAAACCCTACTAAAAATACAAAAATTCACCTGGCGAGGTGGC
AGGCACCTGGAATCCCAGCTACTCGGGAGGCTGAGGCGGTAGAATCACTTGAACCCAGGTGACAGAGGTTGCAGTGATCCAAGATCATGC
CACTGCACTCCAGCCTGGGCGATAGAGTGAGACTCTGTCTCAAACAAACAAAACAAAACAAAATTAGCTGGGTGTGGTGGCACATGCCTG
TAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCGGCAGTTGCAATGAGCCGAGATGGCACCATTGCACT
CCAACCTGGGCAACAAGAGTGAAACTCAATTAAAAAAAAAATAGAAAAGAAAGAAAACTTGTTTATGTGGGAGGAGTATATATAAAACCA
AAATCCAGGCTGTGTTTCCACAGTGCTGGGAAGTGGCCAGAAAAAGGCTTATAGGGGCTATGAAACTCTGGTCTTGACATATAAACTTTG
CTCTGACTGGATTTCATAAAATTACAGTGAGGAGGGTAGTCTCTTGTCAGAAAAACTTGTTTCCAAACATTTATGTAATGTCAAGCTCAG
TCTCTCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCAACTCACCGCAA
CTTCCACCTCCCGGTTTCAAGCTATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACGCGCCACCACGCCCGGCTAATTTT
GTATATTCAGTAGAGACAGGGTTTCTCTATGTTGGTCAGGCTGGTCTGGAACTCCTGGCCTCAGGTGATCCACCCGCCTTGGCCTCCCAA
AATGCTGAGATTACAGGCGTGAGCCACCCCGCGCACAGCCTAGACTCTAATTTTATAAAACTTTGTTGAATTTTCTAAGTGTCATTTAGG
ACATATTGTGCTTTTCTGTGGAGCTTATATCTTATCCTCTTATGTGCAACAAAAAGGGGGTCGGAGGTAAATGCTGATGATGTTGTTTAG
TTTTATTTCCTTTTGATCTGGCATGAGTAAATTGCTCTGTTTCCTTAAGCTTGGGTCTGTTACAGAGCTTTGTGCCTTATAGGGTGCTCA
GTGTGTGTTGACAAAGGGAATAAGAACTGTCAGTGCCATAAAGAACCAAAGATTCTGGCTACTTTGTCTTCTTCCTTTCTCTCCCACTAT
GCCTACACTTCCTCTGCCCAGACACTTTTGGAAAGTGTTTAACTGCTGGGTTTTCTTTTTCTTTTTCTTTTTTTTTTTGAGACGGAGTTT
CACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTTGGCTCACCGCAACCTCTACCTCCTGGGTTCAAGTGATTCTCCTGCCTCAG
CCTCCCGAGTAGCTGGGACTACAGGCATGCGCCACAATGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTAGTCG
GGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCTGTCTCGACCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACTGCGCCTGACC
ACCTACCTGCTGGGTTTTCTTTGTATGTCAGCATGGAGTTTTTCCCAAAGAAAGGGAATATGGATGGAGAGAGAGAGGTTATGAACAGGT
TATGTTACAGAGGTTATTGCCTTTGAAACTGGGCCCTCATCATTCTAGACTTGCTTGCTTTGTTATAAATTAGAAGAAACCAGAGGGAGA
TGTGCCAAGTAAACATTCGAATGACTGTTTAGAATATGGTTTTCTTAATTAGCAGTCATGGGGAAAACATGCATTTTTAATTTGGAAAAA
ACCTGACAGTTAACATGGTTCTGTTTACCTTGATTAGTGAAGTAATTTGCTGCAGTGTTACAGAGGAGCAGAATCACTTGGGTCTCAAAA
TAGACTGAAAATTTAACTCCCCAAACCAAATTTAACAAACAGAATTGGTTATTAGAGATTTATAGGCAAAAATATCAGTTTGGAAATTAA
CCTTGGCTACTGGCCACCTTAGCTAGGTTTTCTCCACAGATCTGTTTTCTCCACAGATCTGAGTACTTAACACTTCCCAGATGATTGGAG
AATATTCTGGGCTGTTGGGGATGACAGGAAAATGTGAGGGGGAGTAGCCTAGGTAAGGGTGATGATGAAATTGTTCTATCTGCTGTCAAA
TAATCTTTTCCTGTTTGCAATGTTTTTATTTTTTCTGAGTCCCTTTGGGAACCAGGTGCTAACAAGAAGCTGTTATGTGTGGGATTTCGG
AGCCTTACTTTAACGATAGAGGAACCAAGTATCATTTTAGATATCTTTTATTTATGTTCTCGGTGCATATGTTGACTTTAATCCCTCTTC
CCCCACACCTCGCCCATTAAGGGGAAGGAGGTTAACTCTGCAGATGATATTCAGGCCCAACCAGCTCACTCTCTGGGGTGGCTACTGACT
AAAGGCAGAGAATGTCCATCCAACATGCCCTTCTGACTATACAGTCACCACTTTTTTGGGGGAATTCTTTAGCAGATCTTATTGTTCTTT
CTGCAGAAGCTATCATTCCTACCTCCCCAACCCCCAAAATCTCTAATACAGGCCAAGTCATTTTTTATGATGGGTCTCTGAGATAGGGCA
GTTTGTTAGAGGAGAGGCTAGGGTAGAGAGGGAGAGAATGGAGGTATCTGAAAATAAGTAAGAAAAAGGCATTGATTTTTATTTACTCGG
AACGGTCCTCTTGGCATCCCAGATAAGGGAAATAGGATTTGATCTCCAATTGTATTGCCATGGAGAGAATGGCAGGTGAGGATGCTTTGA
AGTAGTTAGAAATTAAATATTGAATACATTAATGGCAATACCATTTCATGACTTTGCATATCTTTCTGGATTAGTCATGGAAGTTGGGGA
AATATTGCTTAGATCTTCTGGGTTAGAGGATTCCAACTGTTTATTGGCAAGGTTGGATTATTAAGAATCAAATAGCAGACAAAAATGGCT
GGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCTGAGGTGGGTAGATCACTTGAGGTGAGGAGTTCGAGACCAGCCTGGC
CGACATGGCAAAACCCTGTCTCTACCAAAATACAAAAATTAGTTGGGCATGATGGCATACGCCTGTAGTCCCAGCTACTCTGGAGGCTGA
AACAGGAGAATTGCTTGAACCCAAAAGGTGGAGTTTACAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAATAGAGCGAGACT
CTGTCTCAAAAAAAAAAAAAAAAGAAGGAAAGAAAGAAAAAACAGACAAATGGATCAGAATTGGTGCTTGAGCAAGAGAAACTTCGAGCT
TAGGATGGTTGTCTACTTTAAAATAAAGCTGCTGGCCGGGCACAGTGGCTCACGCCTGTAACCTCAGCACTTTGGGAGGCCAAGGCAGGT
GGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCTGGCCCTACTAAAAATACAAAAAATTAGCCGGGCGTGGT
GGTGGGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGACGTGAACCCAGGAGGCAGAGCTTGCAGTGAGCTGAGATCG
CCCCACTGCAACAGATCGCCTGGGCAACAGAATGAGACTCGGTCTCAAAAAATAAAATAAAATAAAATAAAATAAAATAAGTAAAGCTGC
TGGCCAGACATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGATGGGAGGATCACTTGAGGCCAGGCCAGCGTGGTGAAA
CTCAGTCTCTACTAAAAATACAAAAATTAGCCGGGGGTGGTGGCGCATCATCATACTGGTGAGAAAAAAAAAAAAAAAAAAGAGGCCGGG
CGCGGTGGCTCACAAAAAAAAAAAAAAGAAAGAAAAAGGAAAAAAAGAAATATCAGTTTGAGAAATGATTTTTTTTTCTTTTTTCTTTTC
TTTTTTTTTTTTTAAACAGAGTCTCTCTCTGTCACCCAGGCTGGAGCGCAGTGGCATGATCTTGGCTCATTGCAACCTCTGTCTCCCGGG
TTCAAGCGATTCTTCTGCCTCAGCCTCTGAAGTAGCTGGGATTACAGGCACGCGCTAATTTTTGTATTTTTAGTACAGACGGGATTTCAC
CATATTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCCTCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCA
CGCCCAGCCTCTTTTTTTTTTTTTTTTTCTCACCAGTATGATGATGACCATTTTAAGAAAGCTTGTGTGGCTCTCTCCTATCATTACAGA
CCTCCAGAGCTGGAAAATTTGATGCATTTACTGAACTCTTCCTGAAAGTTTAATATGGAGTGGGAATCAGTTTTTGTCCTAATTTATTAG
AGAAGGCTTCCTCTTCTCTACTCCTTGTGCAAACCCATCTCTGGATAGCTAGAAAAGGAACTTCAGAATGGACTATATGTGATGACCACC
TGTATGCACTCTAGGCTCTTATCTGTCTCTATTTTATGTGGTGACTATATCTCAGAAGTACTACCCCTTCTGAGTAGTACTATTATTTCC
TATGCCAATTTTTTTTAAGTCTCTGATGCTGCCCTTTTTAAATTTTTGTCTTATTTTTTAGCCTCTTTAGTATTAGGGGGTGAGGTGACA
TTCCTAGACTCTACAGTAGCAGTTTGGCATGTTAGTGACAGGAAATTGTGATTCCCTATCTCCCCCTCCTCCTACCTTTTCTGCTTTTGT
GATTCCATTGTTCCTATCTCATTGAGGCTTTCCCAGGCATTCGAATTTAGTTAGTAGGTCATTTCTAATCTCTGGGCCTTGTCTTTTCTC
TCTCCGTTCCCCTCCTTCCCTACCACATATTTTTTGTTTATTCTGAGGTGGTTTGTTTCTGAAAGTTAATCTAGGTCACCTTCTATATCC
TGTGCTTTCTAGTTGGCTTTAGACATCTTGTTCTAGCAACAATGATGGTAGCAGCTCTCTCCCTGACCTTGCCCCATGTGCTGTCCTTCT
GTCAAGGCCATTTGTGTGTGTACTGCGGCAGGTGTGTGTGTGGGGGGATGCGCCCAGACTGTTCTCACAATGTCCTCAGTTTTTCAGGTT
GTCTGACAGCTTTATGTACAGCGTATTTTTAGAAAAACTTAAATATACTTCTTTATTTAGGGTTTTATTCTGATGAGCAAGTTTGTGTGT
ATATGTGTGTATGAGCATTTGTATGTATATATACTTATACAGATCTATATTATATATACAGTTTTTGTACTATCATTTAAAATAAAAATG

>96093_96093_2_UBE2G1-GABPB2_UBE2G1_chr17_4269566_ENST00000396981_GABPB2_chr1_151060666_ENST00000368918_length(amino acids)=448AA_BP=0
MSLVDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHMAAADGHAHIVELL
VRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADVHAFSKFDKSAFDIALEKNNAEILVILQEAMQNQVNVNPERANPVTDPVSM
AAPFIFTSGEVVNLASLISSTNTKTTSGDPHASTVQFSNSTTSVLATLAALAEASVPLSNSHRATANTEEIIEGNSVDSSIQQVMGSGGQ
RVITIVTDGVPLGNIQTSIPTGGIGQPFIVTVQDGQQVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKEGNERELLQQQ

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Fusion Gene PPI Analysis for UBE2G1-GABPB2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for UBE2G1-GABPB2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for UBE2G1-GABPB2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source