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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UBE2Q2-FBXO22 (FusionGDB2 ID:96205)

Fusion Gene Summary for UBE2Q2-FBXO22

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE2Q2-FBXO22
Fusion gene ID: 96205
HgeneTgene
Gene symbol

UBE2Q2

FBXO22

Gene ID

92912

26263

Gene nameubiquitin conjugating enzyme E2 Q2F-box protein 22
Synonyms-FBX22|FISTC1
Cytomap

15q24.2

15q24.2

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-conjugating enzyme E2 Q2E2 ubiquitin-conjugating enzyme Q2ubiquitin carrier protein Q2ubiquitin conjugating enzyme E2Q family member 2ubiquitin-protein ligase Q2F-box only protein 22F-box protein FBX22p44FIST domain containing 1
Modification date2020031420200329
UniProtAcc.

Q8NEZ5

Ensembl transtripts involved in fusion geneENST00000562635, ENST00000267938, 
ENST00000338677, ENST00000561851, 
ENST00000569423, 		ENST00000308275, 
ENST00000453211, ENST00000540507, 
ENST00000565131, 
Fusion gene scores* DoF score9 X 6 X 7=3782 X 3 X 3=18
# samples 114
** MAII scorelog2(11/378*10)=-1.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBE2Q2 [Title/Abstract] AND FBXO22 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBE2Q2(76146828)-FBXO22(76205543), # samples:1
UBE2Q2(76165909)-FBXO22(76222224), # samples:1
UBE2Q2(76136187)-FBXO22(76205543), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE2Q2

GO:0070936

protein K48-linked ubiquitination

20061386


check buttonFusion gene breakpoints across UBE2Q2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBXO22 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-21-5786UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
ChimerDB4LUSCTCGA-NC-A5HMUBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
ChimerDB4STADTCGA-CD-A486UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+


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Fusion Gene ORF analysis for UBE2Q2-FBXO22

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000562635ENST00000308275UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
3UTR-3CDSENST00000562635ENST00000453211UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
3UTR-5UTRENST00000562635ENST00000540507UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
3UTR-intronENST00000562635ENST00000565131UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
5CDS-5UTRENST00000267938ENST00000540507UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
5CDS-5UTRENST00000267938ENST00000540507UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
5CDS-5UTRENST00000338677ENST00000540507UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
5CDS-5UTRENST00000338677ENST00000540507UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
5CDS-5UTRENST00000561851ENST00000540507UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
5CDS-5UTRENST00000569423ENST00000540507UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
5CDS-5UTRENST00000569423ENST00000540507UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
5CDS-intronENST00000267938ENST00000565131UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
5CDS-intronENST00000267938ENST00000565131UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
5CDS-intronENST00000267938ENST00000565131UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
5CDS-intronENST00000338677ENST00000565131UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
5CDS-intronENST00000338677ENST00000565131UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
5CDS-intronENST00000338677ENST00000565131UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
5CDS-intronENST00000561851ENST00000565131UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
5CDS-intronENST00000561851ENST00000565131UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
5CDS-intronENST00000569423ENST00000565131UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
5CDS-intronENST00000569423ENST00000565131UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
5CDS-intronENST00000569423ENST00000565131UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
Frame-shiftENST00000267938ENST00000308275UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000267938ENST00000453211UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000267938ENST00000540507UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000338677ENST00000308275UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000338677ENST00000453211UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000338677ENST00000540507UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000561851ENST00000308275UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000561851ENST00000453211UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000561851ENST00000540507UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000569423ENST00000308275UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000569423ENST00000453211UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
Frame-shiftENST00000569423ENST00000540507UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
In-frameENST00000267938ENST00000308275UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
In-frameENST00000267938ENST00000308275UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
In-frameENST00000267938ENST00000453211UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
In-frameENST00000267938ENST00000453211UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
In-frameENST00000338677ENST00000308275UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
In-frameENST00000338677ENST00000308275UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
In-frameENST00000338677ENST00000453211UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
In-frameENST00000338677ENST00000453211UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
In-frameENST00000561851ENST00000308275UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
In-frameENST00000561851ENST00000453211UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
In-frameENST00000569423ENST00000308275UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
In-frameENST00000569423ENST00000308275UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
In-frameENST00000569423ENST00000453211UBE2Q2chr15

76146828

+FBXO22chr15

76205543

+
In-frameENST00000569423ENST00000453211UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
intron-3CDSENST00000561851ENST00000308275UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
intron-3CDSENST00000561851ENST00000453211UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
intron-3CDSENST00000562635ENST00000308275UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
intron-3CDSENST00000562635ENST00000308275UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
intron-3CDSENST00000562635ENST00000453211UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
intron-3CDSENST00000562635ENST00000453211UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
intron-3CDSENST00000562635ENST00000540507UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
intron-5UTRENST00000561851ENST00000540507UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
intron-5UTRENST00000562635ENST00000540507UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
intron-intronENST00000561851ENST00000565131UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+
intron-intronENST00000562635ENST00000565131UBE2Q2chr15

76165909

+FBXO22chr15

76222224

+
intron-intronENST00000562635ENST00000565131UBE2Q2chr15

76136187

+FBXO22chr15

76205543

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for UBE2Q2-FBXO22


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
UBE2Q2chr1576165909+FBXO22chr1576222224+6.25E-070.9999994
UBE2Q2chr1576146828+FBXO22chr1576205543+3.15E-070.99999964
UBE2Q2chr1576136187+FBXO22chr1576205543+1.47E-070.9999999
UBE2Q2chr1576165909+FBXO22chr1576222224+6.25E-070.9999994
UBE2Q2chr1576146828+FBXO22chr1576205543+3.15E-070.99999964
UBE2Q2chr1576136187+FBXO22chr1576205543+1.47E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for UBE2Q2-FBXO22


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:76146828/chr15:76205543)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FBXO22

Q8NEZ5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. {ECO:0000269|PubMed:22972877}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBXO22chr15:76136187chr15:76205543ENST000005405070621_670300.0DomainNote=F-box
TgeneFBXO22chr15:76146828chr15:76205543ENST000005405070621_670300.0DomainNote=F-box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBE2Q2chr15:76136187chr15:76205543ENST00000267938+113134_17860376.0Compositional biasNote=Glu-rich
HgeneUBE2Q2chr15:76136187chr15:76205543ENST00000561851+113134_1780360.0Compositional biasNote=Glu-rich
HgeneUBE2Q2chr15:76146828chr15:76205543ENST00000267938+213134_17894376.0Compositional biasNote=Glu-rich
HgeneUBE2Q2chr15:76146828chr15:76205543ENST00000561851+213134_17878360.0Compositional biasNote=Glu-rich
HgeneUBE2Q2chr15:76136187chr15:76205543ENST00000267938+113204_36860376.0DomainUBC core
HgeneUBE2Q2chr15:76136187chr15:76205543ENST00000561851+113204_3680360.0DomainUBC core
HgeneUBE2Q2chr15:76146828chr15:76205543ENST00000267938+213204_36894376.0DomainUBC core
HgeneUBE2Q2chr15:76146828chr15:76205543ENST00000561851+213204_36878360.0DomainUBC core
TgeneFBXO22chr15:76136187chr15:76205543ENST000003082751721_6793404.0DomainNote=F-box
TgeneFBXO22chr15:76136187chr15:76205543ENST000004532111621_6793277.0DomainNote=F-box
TgeneFBXO22chr15:76146828chr15:76205543ENST000003082751721_6793404.0DomainNote=F-box
TgeneFBXO22chr15:76146828chr15:76205543ENST000004532111621_6793277.0DomainNote=F-box


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Fusion Gene Sequence for UBE2Q2-FBXO22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for UBE2Q2-FBXO22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UBE2Q2-FBXO22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UBE2Q2-FBXO22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource