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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UBE4B-ASCC3 (FusionGDB2 ID:96320)

Fusion Gene Summary for UBE4B-ASCC3

check button Fusion gene summary
Fusion gene informationFusion gene name: UBE4B-ASCC3
Fusion gene ID: 96320
HgeneTgene
Gene symbol

UBE4B

ASCC3

Gene ID

10277

10973

Gene nameubiquitination factor E4Bactivating signal cointegrator 1 complex subunit 3
SynonymsE4|HDNB1|UBOX3|UFD2|UFD2AASC1p200|HELIC1|RNAH
Cytomap

1p36.22

6q16.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin conjugation factor E4 BRING-type E3 ubiquitin transferase E4 BUFD2A-III/UBE4B-III splice isoformhomologous to yeast UFD2homozygously deleted in neuroblastoma-1ubiquitin-fusion degradation protein 2ubiquitination factor E4B (UFD2 homolog, yactivating signal cointegrator 1 complex subunit 3ASC-1 complex subunit P200RNA helicase familyhelicase, ATP binding 1trip4 complex subunit p200
Modification date2020031320200313
UniProtAcc.

Q8N3C0

Ensembl transtripts involved in fusion geneENST00000253251, ENST00000343090, 
ENST00000377153, ENST00000377157, 
ENST00000475795, 		ENST00000369143, 
ENST00000522650, ENST00000369162, 
Fusion gene scores* DoF score18 X 13 X 10=234014 X 10 X 11=1540
# samples 2318
** MAII scorelog2(23/2340*10)=-3.34680276352639
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1540*10)=-3.09686153925259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBE4B [Title/Abstract] AND ASCC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBE4B(10093752)-ASCC3(101127628), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBE4B

GO:0008626

granzyme-mediated apoptotic signaling pathway

11802788

HgeneUBE4B

GO:0009411

response to UV

11802788

HgeneUBE4B

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

23509263

TgeneASCC3

GO:0006307

DNA dealkylation involved in DNA repair

22055184

TgeneASCC3

GO:0032508

DNA duplex unwinding

22055184


check buttonFusion gene breakpoints across UBE4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASCC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BQ-7046-11AUBE4Bchr1

10093752

+ASCC3chr6

101127628

-


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Fusion Gene ORF analysis for UBE4B-ASCC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000253251ENST00000369143UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
5CDS-intronENST00000253251ENST00000522650UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
5CDS-intronENST00000343090ENST00000369143UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
5CDS-intronENST00000343090ENST00000522650UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
5CDS-intronENST00000377153ENST00000369143UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
5CDS-intronENST00000377153ENST00000522650UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
5UTR-3CDSENST00000377157ENST00000369162UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
5UTR-intronENST00000377157ENST00000369143UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
5UTR-intronENST00000377157ENST00000522650UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
In-frameENST00000253251ENST00000369162UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
In-frameENST00000343090ENST00000369162UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
In-frameENST00000377153ENST00000369162UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
intron-3CDSENST00000475795ENST00000369162UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
intron-intronENST00000475795ENST00000369143UBE4Bchr1

10093752

+ASCC3chr6

101127628

-
intron-intronENST00000475795ENST00000522650UBE4Bchr1

10093752

+ASCC3chr6

101127628

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253251UBE4Bchr110093752+ENST00000369162ASCC3chr6101127628-651386383953201493
ENST00000343090UBE4Bchr110093752+ENST00000369162ASCC3chr6101127628-5749997545561493
ENST00000377153UBE4Bchr110093752+ENST00000369162ASCC3chr6101127628-607142139748781493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253251ENST00000369162UBE4Bchr110093752+ASCC3chr6101127628-0.0008279620.9991721
ENST00000343090ENST00000369162UBE4Bchr110093752+ASCC3chr6101127628-0.000301280.99969876
ENST00000377153ENST00000369162UBE4Bchr110093752+ASCC3chr6101127628-0.0005057880.9994942

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Fusion Genomic Features for UBE4B-ASCC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBE4B-ASCC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:10093752/chr6:101127628)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASCC3

Q8N3C0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). {ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:22055184}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneASCC3chr1:10093752chr6:101127628ENST000003691430418_790112.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr1:10093752chr6:101127628ENST0000036914304328_3560112.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr1:10093752chr6:101127628ENST0000052265001318_790732.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr1:10093752chr6:101127628ENST00000522650013328_3560732.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr1:10093752chr6:101127628ENST00000369143041336_15110112.0DomainHelicase ATP-binding 2
TgeneASCC3chr1:10093752chr6:101127628ENST00000369143041544_17390112.0DomainHelicase C-terminal 2
TgeneASCC3chr1:10093752chr6:101127628ENST00000369143041812_21760112.0DomainNote=SEC63 2
TgeneASCC3chr1:10093752chr6:101127628ENST0000036914304486_6690112.0DomainHelicase ATP-binding 1
TgeneASCC3chr1:10093752chr6:101127628ENST0000036914304728_9140112.0DomainHelicase C-terminal 1
TgeneASCC3chr1:10093752chr6:101127628ENST0000036914304978_12870112.0DomainNote=SEC63 1
TgeneASCC3chr1:10093752chr6:101127628ENST0000036916212421336_15117172203.0DomainHelicase ATP-binding 2
TgeneASCC3chr1:10093752chr6:101127628ENST0000036916212421544_17397172203.0DomainHelicase C-terminal 2
TgeneASCC3chr1:10093752chr6:101127628ENST0000036916212421812_21767172203.0DomainNote=SEC63 2
TgeneASCC3chr1:10093752chr6:101127628ENST000003691621242728_9147172203.0DomainHelicase C-terminal 1
TgeneASCC3chr1:10093752chr6:101127628ENST000003691621242978_12877172203.0DomainNote=SEC63 1
TgeneASCC3chr1:10093752chr6:101127628ENST000005226500131336_15110732.0DomainHelicase ATP-binding 2
TgeneASCC3chr1:10093752chr6:101127628ENST000005226500131544_17390732.0DomainHelicase C-terminal 2
TgeneASCC3chr1:10093752chr6:101127628ENST000005226500131812_21760732.0DomainNote=SEC63 2
TgeneASCC3chr1:10093752chr6:101127628ENST00000522650013486_6690732.0DomainHelicase ATP-binding 1
TgeneASCC3chr1:10093752chr6:101127628ENST00000522650013728_9140732.0DomainHelicase C-terminal 1
TgeneASCC3chr1:10093752chr6:101127628ENST00000522650013978_12870732.0DomainNote=SEC63 1
TgeneASCC3chr1:10093752chr6:101127628ENST00000369143041453_14560112.0MotifNote=DEIH box
TgeneASCC3chr1:10093752chr6:101127628ENST0000036914304611_6140112.0MotifNote=DEVH box
TgeneASCC3chr1:10093752chr6:101127628ENST0000036916212421453_14567172203.0MotifNote=DEIH box
TgeneASCC3chr1:10093752chr6:101127628ENST000005226500131453_14560732.0MotifNote=DEIH box
TgeneASCC3chr1:10093752chr6:101127628ENST00000522650013611_6140732.0MotifNote=DEVH box
TgeneASCC3chr1:10093752chr6:101127628ENST00000369143041349_13560112.0Nucleotide bindingATP
TgeneASCC3chr1:10093752chr6:101127628ENST0000036914304499_5060112.0Nucleotide bindingATP
TgeneASCC3chr1:10093752chr6:101127628ENST0000036916212421349_13567172203.0Nucleotide bindingATP
TgeneASCC3chr1:10093752chr6:101127628ENST000005226500131349_13560732.0Nucleotide bindingATP
TgeneASCC3chr1:10093752chr6:101127628ENST00000522650013499_5060732.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBE4Bchr1:10093752chr6:101127628ENST00000253251+1271227_130081174.0DomainNote=U-box
HgeneUBE4Bchr1:10093752chr6:101127628ENST00000343090+1281227_130081303.0DomainNote=U-box
HgeneUBE4Bchr1:10093752chr6:101127628ENST00000377157+1271227_130001062.0DomainNote=U-box
TgeneASCC3chr1:10093752chr6:101127628ENST00000369162124218_797172203.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr1:10093752chr6:101127628ENST000003691621242328_3567172203.0Coiled coilOntology_term=ECO:0000255
TgeneASCC3chr1:10093752chr6:101127628ENST000003691621242486_6697172203.0DomainHelicase ATP-binding 1
TgeneASCC3chr1:10093752chr6:101127628ENST000003691621242611_6147172203.0MotifNote=DEVH box
TgeneASCC3chr1:10093752chr6:101127628ENST000003691621242499_5067172203.0Nucleotide bindingATP


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Fusion Gene Sequence for UBE4B-ASCC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96320_96320_1_UBE4B-ASCC3_UBE4B_chr1_10093752_ENST00000253251_ASCC3_chr6_101127628_ENST00000369162_length(transcript)=6513nt_BP=863nt
GACGGGGTGGGACGGAGGCGGGGAGAGGACGCAGGCGAGAGGAACTCGGCGGCGCGGCGCCCGCGGCCTATTGGCTGCCACGTCCCGGCG
CCAGAAGCCCCGCCTCCCTGACGGGGGTCACGTGATCCCTTTCAAAGATGGCCGCCCTGTTGTTTTGATGAATAATACTTGGTGGGGCGA
GGGGGAAAGAGTAGGGGTGGAGGGGTAGGAGGATTTACTCTTCCAGCGAGAGCTACGCGCATCCCATCCTCCCCCTCCCCCCTACCCGGG
CTCCGGCGTGGAGGCGGGGCGTGGCCGGCCTGCTTTGGGAGGGGAGGGGCTTCCCTTACAGTGCTGGGCTCTGCCAGGACGGCTGTGGGG
TCGCCTTACCTCGGGGTATCCACTCTGCAGTCGACCAGTTCCCGCCAGGAGCAAAGGGTAGGAAGGAGAGCAGGATCTGCTGTAGGAACG
CAGCTACCGCGCCACTATCACGAAGAAACAGCAGGCTCGGGGCACGAGACGAACTGGAGACCGCGCTGCCTAGCTGGGTAACCTGGGAAG
CAGAGGGTAATAAGTGGCGCCTTAAGACAACCCTGTAGCAGCAGCAGTGGCGGCCAAAGGAGGCTGCTCAGGGAACAAGCGGCTGTAGTA
GTCTGTGGGGCGACTGGAGTGACCGAAGCCAAGGCAGTTTAGTGCCTCTCGTGTTCTTATTTTTTAACCTCTGACTATGCAATTCTGAAA
CCTCCCCCATTCGGGGGACCAGACAGCCTGATAGACACCTTCCACTCTCCTTCCTCCCGCCGTGGTCTCGAGAACAGAAGGATCTCTCCT
TAACGCCTTTCACCATTAAGAGGAAAGCGATGGAGGAGCTGAGCGCTGATGAGGTGATGGTGTTTGTACATGCTCGAAATGCCACTGTAA
GAACAGCTATGTCTCTAATAGAAAGAGCAAAAAATTGTGGCCATATTCCCTTCTTTTTTCCTACCCAAGGACATGACTATGTACTTGCAG
AAAAACAGGTACAAAGGTCGAGAAATAAGCAAGTACGAGAATTATTCCCAGATGGTTTTAGTATTCATCATGCAGGAATGCTTCGGCAGG
ACAGAAATTTAGTTGAAAACTTGTTTTCTAATGGGCATATCAAAGTCCTAGTGTGTACAGCTACGTTAGCCTGGGGTGTCAATCTTCCCG
CCCATGCTGTTATTATTAAGGGAACACAAATATATGCTGCAAAAAGAGGCTCCTTTGTTGACCTTGGAATTTTAGATGTCATGCAGATAT
TTGGTCGAGCTGGACGACCACAATTTGACAAATTTGGGGAAGGAATAATTATAACAACGCATGATAAACTCAGCCATTACCTCACTTTGC
TCACTCAACGAAACCCAATTGAGAGTCAGTTTCTGGAAAGCCTTGCAGATAACCTAAATGCAGAGATTGCTCTGGGAACAGTTACTAATG
TGGAAGAAGCAGTGAAGTGGATAAGTTACACTTATCTTTATGTACGGATGAGAGCAAATCCATTAGCATATGGCATCAGTCACAAGGCTT
ATCAGATTGACCCAACATTAAGAAAGCATCGAGAACAGTTGGTCATTGAAGTTGGACGAAAACTAGACAAAGCTCAGATGATTCGTTTTG
AGGAGCGAACTGGATATTTTTCCTCAACTGATTTGGGTAGAACTGCCAGCCATTACTATATTAAATACAACACCATTGAGACCTTTAATG
AACTCTTTGATGCTCACAAAACAGAAGGTGATATCTTTGCCATAGTCTCCAAAGCTGAAGAATTTGATCAAATTAAGGTCAGAGAAGAGG
AAATAGAGGAGTTAGATACCTTATTAAGCAATTTTTGTGAACTCTCCACTCCTGGAGGTGTAGAGAATAGTTATGGGAAAATAAACATCT
TACTTCAAACTTATATCAGCCGAGGAGAAATGGACAGTTTCTCCCTTATATCAGATTCTGCATATGTTGCACAGAATGCAGCTAGAATTG
TCCGTGCTCTTTTTGAAATTGCTCTGAGGAAACGTTGGCCTACCATGACCTACAGGCTCCTGAATCTTAGTAAAGTCATTGACAAGAGGC
TTTGGGGTTGGGCTAGCCCTTTGAGACAATTTTCAATCCTACCACCACACATCCTAACAAGATTAGAAGAAAAAAAGCTTACTGTGGATA
AGCTGAAAGACATGAGGAAAGATGAAATAGGTCACATTTTACATCATGTGAATATTGGACTGAAGGTCAAACAATGTGTTCATCAGATTC
CTTCTGTTATGATGGAAGCATCCATTCAGCCTATCACAAGGACTGTCCTCCGAGTGACACTCAGCATCTATGCTGATTTCACTTGGAATG
ATCAGGTACATGGGACAGTAGGAGAACCTTGGTGGATTTGGGTAGAAGATCCTACAAATGATCATATTTATCATTCAGAGTATTTTCTAG
CTCTAAAAAAACAAGTCATTAGTAAAGAAGCCCAACTACTGGTATTTACAATCCCTATTTTTGAGCCTTTGCCTTCCCAATACTACATCC
GAGCAGTGTCTGATAGATGGTTGGGTGCTGAGGCAGTATGTATTATCAACTTTCAACATCTAATTCTACCAGAGAGACATCCTCCTCATA
CAGAATTACTGGATCTTCAGCCTTTACCAATCACAGCTTTGGGATGTAAAGCATATGAAGCCCTGTACAACTTCAGCCACTTTAACCCTG
TACAGACACAAATATTTCATACATTGTATCACACGGATTGTAATGTCCTACTTGGAGCACCTACTGGATCGGGAAAGACTGTTGCAGCTG
AATTAGCCATTTTCAGAGTCTTCAACAAATACCCTACTTCAAAGGCGGTATATATTGCACCCCTAAAAGCCCTAGTACGTGAAAGAATGG
ATGATTGGAAAGTTAGAATAGAAGAAAAACTTGGTAAAAAAGTTATTGAACTAACAGGGGATGTGACTCCTGATATGAAATCCATTGCCA
AGGCTGACCTTATCGTCACTACGCCAGAGAAGTGGGATGGAGTCAGCAGAAGCTGGCAAAATAGGAACTATGTTCAGCAAGTCACTATTC
TCATCATAGATGAGATCCATCTGCTTGGGGAGGAAAGAGGCCCTGTTCTAGAGGTCATTGTATCTCGAACAAATTTTATCTCATCACACA
CAGAAAAGCCTGTTAGAATAGTTGGACTATCTACTGCATTAGCTAATGCCAGAGACCTTGCTGATTGGCTCAATATTAAGCAGATGGGCT
TGTTTAACTTCCGACCATCAGTACGCCCAGTTCCACTGGAAGTTCACATTCAAGGCTTTCCAGGTCAACATTACTGTCCTCGTATGGCTA
GTATGAACAAGCCTGCATTTCAGGCAATTAGAAGCCATTCTCCAGCCAAACCTGTTTTGATATTTGTCTCATCAAGACGTCAAACTCGTC
TTACTGCTTTGGAATTGATCGCCTTCCTGGCTACTGAAGAAGATCCAAAGCAGTGGTTAAACATGGATGAAAGAGAGATGGAGAACATCA
TTGCAACAGTAAGAGATTCCAACCTCAAGCTGACCCTTGCTTTCGGGATAGGAATGCATCATGCTGGACTACATGAGAGGGACCGAAAAA
CAGTAGAGGAACTATTTGTAAACTGTAAAGTTCAGGTTCTTATTGCTACAAGCACATTAGCCTGGGGTGTAAACTTTCCAGCTCATTTAG
TAATTATTAAGGGAACAGAATACTATGATGGAAAAACAAGACGTTATGTGGATTTTCCCATTACAGATGTCCTCCAGATGATGGGGCGTG
CTGGGAGGCCGCAGTTCGATGACCAAGGCAAAGCTGTAATTCTAGTTCATGACATAAAGAAAGACTTTTATAAAAAATTTCTTTATGAAC
CTTTCCCAGTAGAATCAAGTTTATTAGGAGTGCTCTCTGACCACTTAAATGCAGAGATTGCTGGTGGTACAATTACATCTAAGCAAGATG
CATTGGATTATATCACCTGGACTTACTTTTTCCGACGTCTTATCATGAATCCCAGCTATTACAATTTGGGTGATGTGAGCCATGATTCTG
TGAACAAGTTTCTGTCCCATCTGATTGAGAAGTCCCTGATTGAATTGGAACTTTCCTACTGTATTGAAATTGGAGAGGATAATCGCAGCA
TTGAACCTCTAACTTATGGCCGAATTGCCTCCTATTACTATTTGAAGCATCAAACAGTTAAAATGTTCAAGGACCGCTTGAAGCCTGAAT
GCAGTACTGAAGAACTGCTTTCAATTCTAAGTGATGCAGAAGAATATACAGATTTGCCAGTGAGACACAATGAAGATCATATGAATAGTG
AACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCATTTGACAGCCCTCACACCAAAGCACATCTCCTGCTACAGGCACATCTCA
GCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACCAAAACAGTCTTGGACCAAGCTCTCAGAGTATGTCAGGCAATGCTGGACG
TGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATCACCAACCTGATTCAGATGGTGATCCAGGGTCGGTGGTTAAAGGACTCTT
CTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCACCTTTTCAAGAAATGGAAGCCGATTATGAAGGGCCCACATGCTAGGGGTC
GGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGTGGAGGGAAAGACCATGTATTTAGCTCCATGGTAGAAAGTGAGCTACATG
CTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTGCCAGTGATAAATGTTGGCATAAGTGTTAAAGGCTCGTGGGATGACTTAG
TTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCAGACAAACGAGATGACAACAAATGGATCAAATTGCATGCTGACCAAGAGT
ATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTCCACAAGGGAAAGCCAGAGAGCTGTGCAGTTACTCCTCGATTTCCCAAAT
CAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGATAAGAGAGAACTTATTGCTTTGAAAAGAGTAGGATATATTCGAAATCATC
ATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGAAGGTATATCTACACATTATATTTCATGAGTGACTGCTACCTTGGCCTGG
ACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGTCTTTCTGCACAGGTCAACACCAAGGTCTCTGATTCCCTGACTGACCTGG
CATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGTGGCTAAGAATTCTCTCTGTTCAGTCATCTAGACAAATCGAATTACTTGA
TGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCAGGAAATTGACAGTGGCTGCAGTATTGACTCCAGTGACATAAAGTTAACC
ACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATCTTTATGAGTTTCTTGATATGTAAGATGAAAAAGCATTTAGAATAATCTT
TTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAATCAAATTTTACATCTCACAATGTACTGTTTACATGGATATTGGCTGCTT
TTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGACTTGTCACAGATTTCTAACTCTGCCGCATAAACTATAAATCTGTAAGGT
GGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATATGATCACATGTAGAAGTAGCTTCAAGAATTTCTTGTAGTCATAAATGTT
TAATAATATATGATGTAAAATTATATTATGGAGCCTAATGATGATAACAAAGAAAACAATATACTGATCTTAGAAAATGTAGACATGGTT
AACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCTGACTCAATGTTTTCTTCTGCTTCCTTTAAATAATATCCCCTTACTCATC
TGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTCTATTATCTTTCTGACATATTTATTTACAGAAGTAGAGAAGTATAATCTA
ATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATTTGTCTTTATGCTCTCCAGGAAAAATCTGAGACAGAAAATTTTTCACCCC
TATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTATGTCCAAACAAATTCCTTCTTGAAAAATACTTTTTCAAACTAAAAACTTG
TTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATGAAATTCTACCTTTGTGAAATAATTTCAGTTTTCTTAGCCCTAAAATGAA
TTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTAGAATTTAAGTGTTTCTGAAATTGGAATGTATTGCTTGTATATATCCTTT

>96320_96320_1_UBE4B-ASCC3_UBE4B_chr1_10093752_ENST00000253251_ASCC3_chr6_101127628_ENST00000369162_length(amino acids)=1493AA_BP=735
MEELSADEVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFS
NGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQ
FLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTGYFSST
DLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGE
MDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKLKDMRKDEI
GHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKE
AQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYNFSHFNPVQTQIFHTLY
HTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPE
KWDGVSRSWQNRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRP
VPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLK
LTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQG
KAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIE
KSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIES
NPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIEN
HHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVS
TLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTP

--------------------------------------------------------------
>96320_96320_2_UBE4B-ASCC3_UBE4B_chr1_10093752_ENST00000343090_ASCC3_chr6_101127628_ENST00000369162_length(transcript)=5749nt_BP=99nt
CTCTCCTTCCTCCCGCCGTGGTCTCGAGAACAGAAGGATCTCTCCTTAACGCCTTTCACCATTAAGAGGAAAGCGATGGAGGAGCTGAGC
GCTGATGAGGTGATGGTGTTTGTACATGCTCGAAATGCCACTGTAAGAACAGCTATGTCTCTAATAGAAAGAGCAAAAAATTGTGGCCAT
ATTCCCTTCTTTTTTCCTACCCAAGGACATGACTATGTACTTGCAGAAAAACAGGTACAAAGGTCGAGAAATAAGCAAGTACGAGAATTA
TTCCCAGATGGTTTTAGTATTCATCATGCAGGAATGCTTCGGCAGGACAGAAATTTAGTTGAAAACTTGTTTTCTAATGGGCATATCAAA
GTCCTAGTGTGTACAGCTACGTTAGCCTGGGGTGTCAATCTTCCCGCCCATGCTGTTATTATTAAGGGAACACAAATATATGCTGCAAAA
AGAGGCTCCTTTGTTGACCTTGGAATTTTAGATGTCATGCAGATATTTGGTCGAGCTGGACGACCACAATTTGACAAATTTGGGGAAGGA
ATAATTATAACAACGCATGATAAACTCAGCCATTACCTCACTTTGCTCACTCAACGAAACCCAATTGAGAGTCAGTTTCTGGAAAGCCTT
GCAGATAACCTAAATGCAGAGATTGCTCTGGGAACAGTTACTAATGTGGAAGAAGCAGTGAAGTGGATAAGTTACACTTATCTTTATGTA
CGGATGAGAGCAAATCCATTAGCATATGGCATCAGTCACAAGGCTTATCAGATTGACCCAACATTAAGAAAGCATCGAGAACAGTTGGTC
ATTGAAGTTGGACGAAAACTAGACAAAGCTCAGATGATTCGTTTTGAGGAGCGAACTGGATATTTTTCCTCAACTGATTTGGGTAGAACT
GCCAGCCATTACTATATTAAATACAACACCATTGAGACCTTTAATGAACTCTTTGATGCTCACAAAACAGAAGGTGATATCTTTGCCATA
GTCTCCAAAGCTGAAGAATTTGATCAAATTAAGGTCAGAGAAGAGGAAATAGAGGAGTTAGATACCTTATTAAGCAATTTTTGTGAACTC
TCCACTCCTGGAGGTGTAGAGAATAGTTATGGGAAAATAAACATCTTACTTCAAACTTATATCAGCCGAGGAGAAATGGACAGTTTCTCC
CTTATATCAGATTCTGCATATGTTGCACAGAATGCAGCTAGAATTGTCCGTGCTCTTTTTGAAATTGCTCTGAGGAAACGTTGGCCTACC
ATGACCTACAGGCTCCTGAATCTTAGTAAAGTCATTGACAAGAGGCTTTGGGGTTGGGCTAGCCCTTTGAGACAATTTTCAATCCTACCA
CCACACATCCTAACAAGATTAGAAGAAAAAAAGCTTACTGTGGATAAGCTGAAAGACATGAGGAAAGATGAAATAGGTCACATTTTACAT
CATGTGAATATTGGACTGAAGGTCAAACAATGTGTTCATCAGATTCCTTCTGTTATGATGGAAGCATCCATTCAGCCTATCACAAGGACT
GTCCTCCGAGTGACACTCAGCATCTATGCTGATTTCACTTGGAATGATCAGGTACATGGGACAGTAGGAGAACCTTGGTGGATTTGGGTA
GAAGATCCTACAAATGATCATATTTATCATTCAGAGTATTTTCTAGCTCTAAAAAAACAAGTCATTAGTAAAGAAGCCCAACTACTGGTA
TTTACAATCCCTATTTTTGAGCCTTTGCCTTCCCAATACTACATCCGAGCAGTGTCTGATAGATGGTTGGGTGCTGAGGCAGTATGTATT
ATCAACTTTCAACATCTAATTCTACCAGAGAGACATCCTCCTCATACAGAATTACTGGATCTTCAGCCTTTACCAATCACAGCTTTGGGA
TGTAAAGCATATGAAGCCCTGTACAACTTCAGCCACTTTAACCCTGTACAGACACAAATATTTCATACATTGTATCACACGGATTGTAAT
GTCCTACTTGGAGCACCTACTGGATCGGGAAAGACTGTTGCAGCTGAATTAGCCATTTTCAGAGTCTTCAACAAATACCCTACTTCAAAG
GCGGTATATATTGCACCCCTAAAAGCCCTAGTACGTGAAAGAATGGATGATTGGAAAGTTAGAATAGAAGAAAAACTTGGTAAAAAAGTT
ATTGAACTAACAGGGGATGTGACTCCTGATATGAAATCCATTGCCAAGGCTGACCTTATCGTCACTACGCCAGAGAAGTGGGATGGAGTC
AGCAGAAGCTGGCAAAATAGGAACTATGTTCAGCAAGTCACTATTCTCATCATAGATGAGATCCATCTGCTTGGGGAGGAAAGAGGCCCT
GTTCTAGAGGTCATTGTATCTCGAACAAATTTTATCTCATCACACACAGAAAAGCCTGTTAGAATAGTTGGACTATCTACTGCATTAGCT
AATGCCAGAGACCTTGCTGATTGGCTCAATATTAAGCAGATGGGCTTGTTTAACTTCCGACCATCAGTACGCCCAGTTCCACTGGAAGTT
CACATTCAAGGCTTTCCAGGTCAACATTACTGTCCTCGTATGGCTAGTATGAACAAGCCTGCATTTCAGGCAATTAGAAGCCATTCTCCA
GCCAAACCTGTTTTGATATTTGTCTCATCAAGACGTCAAACTCGTCTTACTGCTTTGGAATTGATCGCCTTCCTGGCTACTGAAGAAGAT
CCAAAGCAGTGGTTAAACATGGATGAAAGAGAGATGGAGAACATCATTGCAACAGTAAGAGATTCCAACCTCAAGCTGACCCTTGCTTTC
GGGATAGGAATGCATCATGCTGGACTACATGAGAGGGACCGAAAAACAGTAGAGGAACTATTTGTAAACTGTAAAGTTCAGGTTCTTATT
GCTACAAGCACATTAGCCTGGGGTGTAAACTTTCCAGCTCATTTAGTAATTATTAAGGGAACAGAATACTATGATGGAAAAACAAGACGT
TATGTGGATTTTCCCATTACAGATGTCCTCCAGATGATGGGGCGTGCTGGGAGGCCGCAGTTCGATGACCAAGGCAAAGCTGTAATTCTA
GTTCATGACATAAAGAAAGACTTTTATAAAAAATTTCTTTATGAACCTTTCCCAGTAGAATCAAGTTTATTAGGAGTGCTCTCTGACCAC
TTAAATGCAGAGATTGCTGGTGGTACAATTACATCTAAGCAAGATGCATTGGATTATATCACCTGGACTTACTTTTTCCGACGTCTTATC
ATGAATCCCAGCTATTACAATTTGGGTGATGTGAGCCATGATTCTGTGAACAAGTTTCTGTCCCATCTGATTGAGAAGTCCCTGATTGAA
TTGGAACTTTCCTACTGTATTGAAATTGGAGAGGATAATCGCAGCATTGAACCTCTAACTTATGGCCGAATTGCCTCCTATTACTATTTG
AAGCATCAAACAGTTAAAATGTTCAAGGACCGCTTGAAGCCTGAATGCAGTACTGAAGAACTGCTTTCAATTCTAAGTGATGCAGAAGAA
TATACAGATTTGCCAGTGAGACACAATGAAGATCATATGAATAGTGAACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCATTT
GACAGCCCTCACACCAAAGCACATCTCCTGCTACAGGCACATCTCAGCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACCAAA
ACAGTCTTGGACCAAGCTCTCAGAGTATGTCAGGCAATGCTGGACGTGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATCACC
AACCTGATTCAGATGGTGATCCAGGGTCGGTGGTTAAAGGACTCTTCTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCACCTT
TTCAAGAAATGGAAGCCGATTATGAAGGGCCCACATGCTAGGGGTCGGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGTGGA
GGGAAAGACCATGTATTTAGCTCCATGGTAGAAAGTGAGCTACATGCTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTGCCA
GTGATAAATGTTGGCATAAGTGTTAAAGGCTCGTGGGATGACTTAGTTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCAGAC
AAACGAGATGACAACAAATGGATCAAATTGCATGCTGACCAAGAGTATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTCCAC
AAGGGAAAGCCAGAGAGCTGTGCAGTTACTCCTCGATTTCCCAAATCAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGATAAG
AGAGAACTTATTGCTTTGAAAAGAGTAGGATATATTCGAAATCATCATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGAAGG
TATATCTACACATTATATTTCATGAGTGACTGCTACCTTGGCCTGGACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGTCTT
TCTGCACAGGTCAACACCAAGGTCTCTGATTCCCTGACTGACCTGGCATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGTGGC
TAAGAATTCTCTCTGTTCAGTCATCTAGACAAATCGAATTACTTGATGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCAGGA
AATTGACAGTGGCTGCAGTATTGACTCCAGTGACATAAAGTTAACCACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATCTTT
ATGAGTTTCTTGATATGTAAGATGAAAAAGCATTTAGAATAATCTTTTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAATCA
AATTTTACATCTCACAATGTACTGTTTACATGGATATTGGCTGCTTTTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGACTT
GTCACAGATTTCTAACTCTGCCGCATAAACTATAAATCTGTAAGGTGGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATATGA
TCACATGTAGAAGTAGCTTCAAGAATTTCTTGTAGTCATAAATGTTTAATAATATATGATGTAAAATTATATTATGGAGCCTAATGATGA
TAACAAAGAAAACAATATACTGATCTTAGAAAATGTAGACATGGTTAACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCTGAC
TCAATGTTTTCTTCTGCTTCCTTTAAATAATATCCCCTTACTCATCTGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTCTAT
TATCTTTCTGACATATTTATTTACAGAAGTAGAGAAGTATAATCTAATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATTTGT
CTTTATGCTCTCCAGGAAAAATCTGAGACAGAAAATTTTTCACCCCTATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTATGTC
CAAACAAATTCCTTCTTGAAAAATACTTTTTCAAACTAAAAACTTGTTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATGAAA
TTCTACCTTTGTGAAATAATTTCAGTTTTCTTAGCCCTAAAATGAATTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTAGAA

>96320_96320_2_UBE4B-ASCC3_UBE4B_chr1_10093752_ENST00000343090_ASCC3_chr6_101127628_ENST00000369162_length(amino acids)=1493AA_BP=735
MEELSADEVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFS
NGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQ
FLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTGYFSST
DLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGE
MDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKLKDMRKDEI
GHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKE
AQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYNFSHFNPVQTQIFHTLY
HTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPE
KWDGVSRSWQNRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRP
VPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLK
LTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQG
KAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIE
KSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIES
NPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIEN
HHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVS
TLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTP

--------------------------------------------------------------
>96320_96320_3_UBE4B-ASCC3_UBE4B_chr1_10093752_ENST00000377153_ASCC3_chr6_101127628_ENST00000369162_length(transcript)=6071nt_BP=421nt
TAGGAACGCAGCTACCGCGCCACTATCACGAAGAAACAGCAGGCTCGGGGCACGAGACGAACTGGAGACCGCGCTGCCTAGCTGGGTAAC
CTGGGAAGCAGAGGGTAATAAGTGGCGCCTTAAGACAACCCTGTAGCAGCAGCAGTGGCGGCCAAAGGAGGCTGCTCAGGGAACAAGCGG
CTGTAGTAGTCTGTGGGGCGACTGGAGTGACCGAAGCCAAGGCAGTTTAGTGCCTCTCGTGTTCTTATTTTTTAACCTCTGACTATGCAA
TTCTGAAACCTCCCCCATTCGGGGGACCAGACAGCCTGATAGACACCTTCCACTCTCCTTCCTCCCGCCGTGGTCTCGAGAACAGAAGGA
TCTCTCCTTAACGCCTTTCACCATTAAGAGGAAAGCGATGGAGGAGCTGAGCGCTGATGAGGTGATGGTGTTTGTACATGCTCGAAATGC
CACTGTAAGAACAGCTATGTCTCTAATAGAAAGAGCAAAAAATTGTGGCCATATTCCCTTCTTTTTTCCTACCCAAGGACATGACTATGT
ACTTGCAGAAAAACAGGTACAAAGGTCGAGAAATAAGCAAGTACGAGAATTATTCCCAGATGGTTTTAGTATTCATCATGCAGGAATGCT
TCGGCAGGACAGAAATTTAGTTGAAAACTTGTTTTCTAATGGGCATATCAAAGTCCTAGTGTGTACAGCTACGTTAGCCTGGGGTGTCAA
TCTTCCCGCCCATGCTGTTATTATTAAGGGAACACAAATATATGCTGCAAAAAGAGGCTCCTTTGTTGACCTTGGAATTTTAGATGTCAT
GCAGATATTTGGTCGAGCTGGACGACCACAATTTGACAAATTTGGGGAAGGAATAATTATAACAACGCATGATAAACTCAGCCATTACCT
CACTTTGCTCACTCAACGAAACCCAATTGAGAGTCAGTTTCTGGAAAGCCTTGCAGATAACCTAAATGCAGAGATTGCTCTGGGAACAGT
TACTAATGTGGAAGAAGCAGTGAAGTGGATAAGTTACACTTATCTTTATGTACGGATGAGAGCAAATCCATTAGCATATGGCATCAGTCA
CAAGGCTTATCAGATTGACCCAACATTAAGAAAGCATCGAGAACAGTTGGTCATTGAAGTTGGACGAAAACTAGACAAAGCTCAGATGAT
TCGTTTTGAGGAGCGAACTGGATATTTTTCCTCAACTGATTTGGGTAGAACTGCCAGCCATTACTATATTAAATACAACACCATTGAGAC
CTTTAATGAACTCTTTGATGCTCACAAAACAGAAGGTGATATCTTTGCCATAGTCTCCAAAGCTGAAGAATTTGATCAAATTAAGGTCAG
AGAAGAGGAAATAGAGGAGTTAGATACCTTATTAAGCAATTTTTGTGAACTCTCCACTCCTGGAGGTGTAGAGAATAGTTATGGGAAAAT
AAACATCTTACTTCAAACTTATATCAGCCGAGGAGAAATGGACAGTTTCTCCCTTATATCAGATTCTGCATATGTTGCACAGAATGCAGC
TAGAATTGTCCGTGCTCTTTTTGAAATTGCTCTGAGGAAACGTTGGCCTACCATGACCTACAGGCTCCTGAATCTTAGTAAAGTCATTGA
CAAGAGGCTTTGGGGTTGGGCTAGCCCTTTGAGACAATTTTCAATCCTACCACCACACATCCTAACAAGATTAGAAGAAAAAAAGCTTAC
TGTGGATAAGCTGAAAGACATGAGGAAAGATGAAATAGGTCACATTTTACATCATGTGAATATTGGACTGAAGGTCAAACAATGTGTTCA
TCAGATTCCTTCTGTTATGATGGAAGCATCCATTCAGCCTATCACAAGGACTGTCCTCCGAGTGACACTCAGCATCTATGCTGATTTCAC
TTGGAATGATCAGGTACATGGGACAGTAGGAGAACCTTGGTGGATTTGGGTAGAAGATCCTACAAATGATCATATTTATCATTCAGAGTA
TTTTCTAGCTCTAAAAAAACAAGTCATTAGTAAAGAAGCCCAACTACTGGTATTTACAATCCCTATTTTTGAGCCTTTGCCTTCCCAATA
CTACATCCGAGCAGTGTCTGATAGATGGTTGGGTGCTGAGGCAGTATGTATTATCAACTTTCAACATCTAATTCTACCAGAGAGACATCC
TCCTCATACAGAATTACTGGATCTTCAGCCTTTACCAATCACAGCTTTGGGATGTAAAGCATATGAAGCCCTGTACAACTTCAGCCACTT
TAACCCTGTACAGACACAAATATTTCATACATTGTATCACACGGATTGTAATGTCCTACTTGGAGCACCTACTGGATCGGGAAAGACTGT
TGCAGCTGAATTAGCCATTTTCAGAGTCTTCAACAAATACCCTACTTCAAAGGCGGTATATATTGCACCCCTAAAAGCCCTAGTACGTGA
AAGAATGGATGATTGGAAAGTTAGAATAGAAGAAAAACTTGGTAAAAAAGTTATTGAACTAACAGGGGATGTGACTCCTGATATGAAATC
CATTGCCAAGGCTGACCTTATCGTCACTACGCCAGAGAAGTGGGATGGAGTCAGCAGAAGCTGGCAAAATAGGAACTATGTTCAGCAAGT
CACTATTCTCATCATAGATGAGATCCATCTGCTTGGGGAGGAAAGAGGCCCTGTTCTAGAGGTCATTGTATCTCGAACAAATTTTATCTC
ATCACACACAGAAAAGCCTGTTAGAATAGTTGGACTATCTACTGCATTAGCTAATGCCAGAGACCTTGCTGATTGGCTCAATATTAAGCA
GATGGGCTTGTTTAACTTCCGACCATCAGTACGCCCAGTTCCACTGGAAGTTCACATTCAAGGCTTTCCAGGTCAACATTACTGTCCTCG
TATGGCTAGTATGAACAAGCCTGCATTTCAGGCAATTAGAAGCCATTCTCCAGCCAAACCTGTTTTGATATTTGTCTCATCAAGACGTCA
AACTCGTCTTACTGCTTTGGAATTGATCGCCTTCCTGGCTACTGAAGAAGATCCAAAGCAGTGGTTAAACATGGATGAAAGAGAGATGGA
GAACATCATTGCAACAGTAAGAGATTCCAACCTCAAGCTGACCCTTGCTTTCGGGATAGGAATGCATCATGCTGGACTACATGAGAGGGA
CCGAAAAACAGTAGAGGAACTATTTGTAAACTGTAAAGTTCAGGTTCTTATTGCTACAAGCACATTAGCCTGGGGTGTAAACTTTCCAGC
TCATTTAGTAATTATTAAGGGAACAGAATACTATGATGGAAAAACAAGACGTTATGTGGATTTTCCCATTACAGATGTCCTCCAGATGAT
GGGGCGTGCTGGGAGGCCGCAGTTCGATGACCAAGGCAAAGCTGTAATTCTAGTTCATGACATAAAGAAAGACTTTTATAAAAAATTTCT
TTATGAACCTTTCCCAGTAGAATCAAGTTTATTAGGAGTGCTCTCTGACCACTTAAATGCAGAGATTGCTGGTGGTACAATTACATCTAA
GCAAGATGCATTGGATTATATCACCTGGACTTACTTTTTCCGACGTCTTATCATGAATCCCAGCTATTACAATTTGGGTGATGTGAGCCA
TGATTCTGTGAACAAGTTTCTGTCCCATCTGATTGAGAAGTCCCTGATTGAATTGGAACTTTCCTACTGTATTGAAATTGGAGAGGATAA
TCGCAGCATTGAACCTCTAACTTATGGCCGAATTGCCTCCTATTACTATTTGAAGCATCAAACAGTTAAAATGTTCAAGGACCGCTTGAA
GCCTGAATGCAGTACTGAAGAACTGCTTTCAATTCTAAGTGATGCAGAAGAATATACAGATTTGCCAGTGAGACACAATGAAGATCATAT
GAATAGTGAACTGGCAAAATGTCTTCCCATTGAATCAAATCCTCATTCATTTGACAGCCCTCACACCAAAGCACATCTCCTGCTACAGGC
ACATCTCAGCCGAGCCATGCTACCCTGCCCAGATTATGACACTGATACCAAAACAGTCTTGGACCAAGCTCTCAGAGTATGTCAGGCAAT
GCTGGACGTGGCTGCAAACCAGGGCTGGCTGGTGACTGTCCTGAATATCACCAACCTGATTCAGATGGTGATCCAGGGTCGGTGGTTAAA
GGACTCTTCTCTTCTTACACTACCAAACATAGAAAACCATCATCTTCACCTTTTCAAGAAATGGAAGCCGATTATGAAGGGCCCACATGC
TAGGGGTCGGACCTCCATCGAGTCCCTTCCTGAACTGATCCATGCCTGTGGAGGGAAAGACCATGTATTTAGCTCCATGGTAGAAAGTGA
GCTACATGCTGCAAAAACGAAACAGGCATGGAATTTCTTATCTCACTTGCCAGTGATAAATGTTGGCATAAGTGTTAAAGGCTCGTGGGA
TGACTTAGTTGAAGGACATAATGAACTCTCTGTCTCAACTCTGACTGCAGACAAACGAGATGACAACAAATGGATCAAATTGCATGCTGA
CCAAGAGTATGTGCTTCAAGTGAGCTTGCAGAGAGTCCACTTTGGGTTCCACAAGGGAAAGCCAGAGAGCTGTGCAGTTACTCCTCGATT
TCCCAAATCAAAAGACGAAGGATGGTTTTTGATATTAGGAGAAGTGGATAAGAGAGAACTTATTGCTTTGAAAAGAGTAGGATATATTCG
AAATCATCATGTTGCTTCCCTTTCTTTTTATACCCCTGAAATACCTGGAAGGTATATCTACACATTATATTTCATGAGTGACTGCTACCT
TGGCCTGGACCAGCAGTATGACATCTATCTCAACGTTACACAAGCGAGTCTTTCTGCACAGGTCAACACCAAGGTCTCTGATTCCCTGAC
TGACCTGGCATTAAAGTAACTTGACCTGAACAATCCATTTGAAAGGAGTGGCTAAGAATTCTCTCTGTTCAGTCATCTAGACAAATCGAA
TTACTTGATGTTTGCCTTGAAAGAATCAACTTCTAACCTCAACCATCCAGGAAATTGACAGTGGCTGCAGTATTGACTCCAGTGACATAA
AGTTAACCACAGTGGCCTTTTAACAAATGTTGCCTTTTATAATGTTATCTTTATGAGTTTCTTGATATGTAAGATGAAAAAGCATTTAGA
ATAATCTTTTAATTTGTGTATATTTGGGATGATATTTAGGAGCTATCAATCAAATTTTACATCTCACAATGTACTGTTTACATGGATATT
GGCTGCTTTTTTTAAGGAAAACCACATTGAGATGTGACAAGTGTTAGGACTTGTCACAGATTTCTAACTCTGCCGCATAAACTATAAATC
TGTAAGGTGGTACACAGCGTGTCTTGTTAGCAAAATTTATACTTTGATATGATCACATGTAGAAGTAGCTTCAAGAATTTCTTGTAGTCA
TAAATGTTTAATAATATATGATGTAAAATTATATTATGGAGCCTAATGATGATAACAAAGAAAACAATATACTGATCTTAGAAAATGTAG
ACATGGTTAACTGGGAAATAAAATATAGAGTGGCACTTCAAGACAAGCTGACTCAATGTTTTCTTCTGCTTCCTTTAAATAATATCCCCT
TACTCATCTGTTCTTCTTTTCTTTCCCTTCTACTTCAAGGCTTTATTTCTATTATCTTTCTGACATATTTATTTACAGAAGTAGAGAAGT
ATAATCTAATTCATGTTGTAGCACTTACAGATCATATAGTACAATTATTTGTCTTTATGCTCTCCAGGAAAAATCTGAGACAGAAAATTT
TTCACCCCTATGGATAGGTTTTCACCTGTAATAAAGAAAATTTCTCTATGTCCAAACAAATTCCTTCTTGAAAAATACTTTTTCAAACTA
AAAACTTGTTAAAATTCAATGTTCATATAATATGCATTCTAGTGGAATGAAATTCTACCTTTGTGAAATAATTTCAGTTTTCTTAGCCCT
AAAATGAATTATTTTAAAACATTTTCCAATGTCATTGTTACAAATACTAGAATTTAAGTGTTTCTGAAATTGGAATGTATTGCTTGTATA

>96320_96320_3_UBE4B-ASCC3_UBE4B_chr1_10093752_ENST00000377153_ASCC3_chr6_101127628_ENST00000369162_length(amino acids)=1493AA_BP=735
MEELSADEVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFS
NGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQ
FLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTGYFSST
DLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGE
MDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKLKDMRKDEI
GHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKE
AQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYNFSHFNPVQTQIFHTLY
HTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPE
KWDGVSRSWQNRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRP
VPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLK
LTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQG
KAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIE
KSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIES
NPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIEN
HHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVS
TLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTP

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Fusion Gene PPI Analysis for UBE4B-ASCC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UBE4B-ASCC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UBE4B-ASCC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource