FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:UBQLN1-NLRP5 (FusionGDB2 ID:96404)

Fusion Gene Summary for UBQLN1-NLRP5

check button Fusion gene summary
Fusion gene informationFusion gene name: UBQLN1-NLRP5
Fusion gene ID: 96404
HgeneTgene
Gene symbol

UBQLN1

NLRP5

Gene ID

29979

126206

Gene nameubiquilin 1NLR family pyrin domain containing 5
SynonymsDA41|DSK2|PLIC-1|UBQN|XDRP1CLR19.8|MATER|NALP5|PAN11|PYPAF8
Cytomap

9q21.32|9q21.2-q21.3

19q13.43

Type of geneprotein-codingprotein-coding
Descriptionubiquilin-1hPLIC-1protein linking IAP with cytoskeleton 1testicular tissue protein Li 219NACHT, LRR and PYD domains-containing protein 5NACHT, leucine rich repeat and PYD containing 5mater protein homologmaternal antigen that embryos requirenucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000257468, ENST00000376395, 
ENST00000390649, 
Fusion gene scores* DoF score14 X 12 X 8=13444 X 6 X 3=72
# samples 165
** MAII scorelog2(16/1344*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBQLN1 [Title/Abstract] AND NLRP5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBQLN1(86292642)-NLRP5(56531741), # samples:1
UBQLN1(86292641)-NLRP5(56530707), # samples:1
UBQLN1(86292641)-NLRP5(56531740), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBQLN1

GO:0031396

regulation of protein ubiquitination

12634373

HgeneUBQLN1

GO:0031398

positive regulation of protein ubiquitination

23307288

HgeneUBQLN1

GO:0035973

aggrephagy

21143716


check buttonFusion gene breakpoints across UBQLN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NLRP5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6YR-01AUBQLN1chr9

86292642

-NLRP5chr19

56531741

+
ChimerDB4SARCTCGA-DX-A6YRUBQLN1chr9

86292641

-NLRP5chr19

56530707

+
ChimerDB4SARCTCGA-DX-A6YRUBQLN1chr9

86292641

-NLRP5chr19

56531740

+


Top

Fusion Gene ORF analysis for UBQLN1-NLRP5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000257468ENST00000390649UBQLN1chr9

86292642

-NLRP5chr19

56531741

+
In-frameENST00000257468ENST00000390649UBQLN1chr9

86292641

-NLRP5chr19

56530707

+
In-frameENST00000257468ENST00000390649UBQLN1chr9

86292641

-NLRP5chr19

56531740

+
In-frameENST00000376395ENST00000390649UBQLN1chr9

86292642

-NLRP5chr19

56531741

+
In-frameENST00000376395ENST00000390649UBQLN1chr9

86292641

-NLRP5chr19

56530707

+
In-frameENST00000376395ENST00000390649UBQLN1chr9

86292641

-NLRP5chr19

56531740

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376395UBQLN1chr986292642-ENST00000390649NLRP5chr1956531741+4895162952446091361
ENST00000257468UBQLN1chr986292642-ENST00000390649NLRP5chr1956531741+4626136025543401361
ENST00000376395UBQLN1chr986292641-ENST00000390649NLRP5chr1956530707+4952162952446661380
ENST00000257468UBQLN1chr986292641-ENST00000390649NLRP5chr1956530707+4683136025543971380
ENST00000376395UBQLN1chr986292641-ENST00000390649NLRP5chr1956531740+4895162952446091361
ENST00000257468UBQLN1chr986292641-ENST00000390649NLRP5chr1956531740+4626136025543401361

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376395ENST00000390649UBQLN1chr986292642-NLRP5chr1956531741+0.0014615130.9985385
ENST00000257468ENST00000390649UBQLN1chr986292642-NLRP5chr1956531741+0.0011033940.9988966
ENST00000376395ENST00000390649UBQLN1chr986292641-NLRP5chr1956530707+0.0015746860.99842536
ENST00000257468ENST00000390649UBQLN1chr986292641-NLRP5chr1956530707+0.0011840220.998816
ENST00000376395ENST00000390649UBQLN1chr986292641-NLRP5chr1956531740+0.0014615130.9985385
ENST00000257468ENST00000390649UBQLN1chr986292641-NLRP5chr1956531740+0.0011033940.9988966

Top

Fusion Genomic Features for UBQLN1-NLRP5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
UBQLN1chr986292641-NLRP5chr1956531740+1.42E-081
UBQLN1chr986292641-NLRP5chr1956530707+3.44E-101
UBQLN1chr986292641-NLRP5chr1956531740+1.42E-081
UBQLN1chr986292641-NLRP5chr1956531740+1.42E-081
UBQLN1chr986292641-NLRP5chr1956530707+3.44E-101
UBQLN1chr986292641-NLRP5chr1956531740+1.42E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for UBQLN1-NLRP5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:86292642/chr19:56531741)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610182_210368562.0DomainSTI1 1
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610212_251368562.0DomainSTI1 2
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-61037_111368562.0DomainUbiquitin-like
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611182_210368590.0DomainSTI1 1
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611212_251368590.0DomainSTI1 2
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-61137_111368590.0DomainUbiquitin-like
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610182_210368562.0DomainSTI1 1
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610212_251368562.0DomainSTI1 2
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-61037_111368562.0DomainUbiquitin-like
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611182_210368590.0DomainSTI1 1
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611212_251368590.0DomainSTI1 2
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-61137_111368590.0DomainUbiquitin-like
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610182_210368562.0DomainSTI1 1
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610212_251368562.0DomainSTI1 2
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-61037_111368562.0DomainUbiquitin-like
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611182_210368590.0DomainSTI1 1
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611212_251368590.0DomainSTI1 2
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-61137_111368590.0DomainUbiquitin-like
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315280_6021881201.0DomainNACHT
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415280_6022071201.0DomainNACHT
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415280_6022071201.0DomainNACHT
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315286_2931881201.0Nucleotide bindingATP
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415286_2932071201.0Nucleotide bindingATP
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415286_2932071201.0Nucleotide bindingATP
TgeneNLRP5chr9:86292641chr19:56530707ENST000003906493151007_10341881201.0RepeatNote=LRR 10
TgeneNLRP5chr9:86292641chr19:56530707ENST000003906493151036_10591881201.0RepeatNote=LRR 11
TgeneNLRP5chr9:86292641chr19:56530707ENST000003906493151064_10921881201.0RepeatNote=LRR 12
TgeneNLRP5chr9:86292641chr19:56530707ENST000003906493151121_11421881201.0RepeatNote=LRR 13
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315704_7271881201.0RepeatNote=LRR 1
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315730_7531881201.0RepeatNote=LRR 2
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315780_8031881201.0RepeatNote=LRR 3
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315809_8321881201.0RepeatNote=LRR 4
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315836_8631881201.0RepeatNote=LRR 5
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315865_8921881201.0RepeatNote=LRR 6
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315893_9161881201.0RepeatNote=LRR 7
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315950_9731881201.0RepeatNote=LRR 8
TgeneNLRP5chr9:86292641chr19:56530707ENST00000390649315979_10021881201.0RepeatNote=LRR 9
TgeneNLRP5chr9:86292641chr19:56531740ENST000003906494151007_10342071201.0RepeatNote=LRR 10
TgeneNLRP5chr9:86292641chr19:56531740ENST000003906494151036_10592071201.0RepeatNote=LRR 11
TgeneNLRP5chr9:86292641chr19:56531740ENST000003906494151064_10922071201.0RepeatNote=LRR 12
TgeneNLRP5chr9:86292641chr19:56531740ENST000003906494151121_11422071201.0RepeatNote=LRR 13
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415704_7272071201.0RepeatNote=LRR 1
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415730_7532071201.0RepeatNote=LRR 2
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415780_8032071201.0RepeatNote=LRR 3
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415809_8322071201.0RepeatNote=LRR 4
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415836_8632071201.0RepeatNote=LRR 5
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415865_8922071201.0RepeatNote=LRR 6
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415893_9162071201.0RepeatNote=LRR 7
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415950_9732071201.0RepeatNote=LRR 8
TgeneNLRP5chr9:86292641chr19:56531740ENST00000390649415979_10022071201.0RepeatNote=LRR 9
TgeneNLRP5chr9:86292642chr19:56531741ENST000003906494151007_10342071201.0RepeatNote=LRR 10
TgeneNLRP5chr9:86292642chr19:56531741ENST000003906494151036_10592071201.0RepeatNote=LRR 11
TgeneNLRP5chr9:86292642chr19:56531741ENST000003906494151064_10922071201.0RepeatNote=LRR 12
TgeneNLRP5chr9:86292642chr19:56531741ENST000003906494151121_11422071201.0RepeatNote=LRR 13
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415704_7272071201.0RepeatNote=LRR 1
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415730_7532071201.0RepeatNote=LRR 2
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415780_8032071201.0RepeatNote=LRR 3
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415809_8322071201.0RepeatNote=LRR 4
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415836_8632071201.0RepeatNote=LRR 5
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415865_8922071201.0RepeatNote=LRR 6
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415893_9162071201.0RepeatNote=LRR 7
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415950_9732071201.0RepeatNote=LRR 8
TgeneNLRP5chr9:86292642chr19:56531741ENST00000390649415979_10022071201.0RepeatNote=LRR 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610387_434368562.0DomainSTI1 3
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610438_470368562.0DomainSTI1 4
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610546_586368562.0DomainUBA
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611387_434368590.0DomainSTI1 3
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611438_470368590.0DomainSTI1 4
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611546_586368590.0DomainUBA
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610387_434368562.0DomainSTI1 3
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610438_470368562.0DomainSTI1 4
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610546_586368562.0DomainUBA
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611387_434368590.0DomainSTI1 3
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611438_470368590.0DomainSTI1 4
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611546_586368590.0DomainUBA
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610387_434368562.0DomainSTI1 3
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610438_470368562.0DomainSTI1 4
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610546_586368562.0DomainUBA
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611387_434368590.0DomainSTI1 3
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611438_470368590.0DomainSTI1 4
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611546_586368590.0DomainUBA
TgeneNLRP5chr9:86292641chr19:56530707ENST0000039064931557_1481881201.0DomainPyrin
TgeneNLRP5chr9:86292641chr19:56531740ENST0000039064941557_1482071201.0DomainPyrin
TgeneNLRP5chr9:86292642chr19:56531741ENST0000039064941557_1482071201.0DomainPyrin


Top

Fusion Gene Sequence for UBQLN1-NLRP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96404_96404_1_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000257468_NLRP5_chr19_56530707_ENST00000390649_length(transcript)=4683nt_BP=1360nt
GCGGATGTCGGTGTGAGCGAGCGGCGCCTGAACACACGGCGGCTGCCGAGCGCCTGACCCGGGCCTGCGCCAGAGCCTGCACCGAGCTCC
GGGGCCCCACACCCGCTACGGTGGCCCTGCGCCCGTTGCTACTGAGGCGGCGTGCTCTGCATTCTTCGCTGTCCAGGCCTGCCGGCTCTG
GTGTCTGCTGGCTCCTCCTTGCTCGCCTGCTCCCTCCTGCTTGCCTGAGTCACCGCCGCCGCCGCCGCCACAGCCATGGCCGAGAGTGGT
GAAAGCGGCGGTCCTCCGGGCTCCCAGGATAGCGCCGCCGGAGCCGAAGGTGCTGGCGCCCCCGCGGCCGCTGCCTCCGCGGAGCCCAAA
ATCATGAAAGTCACCGTGAAGACCCCGAAGGAAAAGGAGGAATTCGCCGTGCCCGAGAATAGCTCCGTCCAGCAGTTTAAGGAAGAAATC
TCTAAACGTTTTAAATCACATACTGACCAACTTGTGTTGATATTTGCTGGAAAAATTTTGAAAGATCAAGATACCTTGAGTCAGCATGGA
ATTCATGATGGACTTACTGTTCACCTTGTCATTAAAACACAAAACAGGCCTCAGGATCATTCAGCTCAGCAAACAAATACAGCTGGAAGC
AATGTTACTACATCATCAACTCCTAATAGTAACTCTACATCTGGTTCTGCTACTAGCAACCCTTTTGGTTTAGGTGGCCTTGGGGGACTT
GCAGGTCTGAGTAGCTTGGGTTTGAATACTACCAACTTCTCTGAACTACAGAGTCAGATGCAGCGACAACTTTTGTCTAACCCTGAAATG
ATGGTCCAGATCATGGAAAATCCCTTTGTTCAGAGCATGCTCTCAAATCCTGACCTGATGAGACAGTTAATTATGGCCAATCCACAAATG
CAGCAGTTGATACAGAGAAATCCAGAAATTAGTCATATGTTGAATAATCCAGATATAATGAGACAAACGTTGGAACTTGCCAGGAATCCA
GCAATGATGCAGGAGATGATGAGGAACCAGGACCGAGCTTTGAGCAACCTAGAAAGCATCCCAGGGGGATATAATGCTTTAAGGCGCATG
TACACAGATATTCAGGAACCAATGCTGAGTGCTGCACAAGAGCAGTTTGGTGGTAATCCATTTGCTTCCTTGGTGAGCAATACATCCTCT
GGTGAAGGTAGTCAACCTTCCCGTACAGAAAATAGAGATCCACTACCCAATCCATGGGCTCCACAGACTTCCCAGAGTTCATCAGCTTCC
AGCGGCACTGCCAGCACTGTGGGTGGCACTACTGGTAGTACTGCCAGTGGCACTTCTGGGCAGAGTACTACTGCGCCAAATTTGGTGCCT
GGAGTAGGAGAAATTTCACAAGCTATGGAACAAGAAGGTGCCACAGCAGCAGAGACAGAAGAACAAGAAATTTCACAAGCTATGGAACAA
GAAGGTGCCACAGCAGCAGAGACAGAAGAACAAGGACATGGAGGTGACACATGGGACTACAAGAGTCACGTGATGACCAAATTCGCTGAG
GAGGAGGATGTACGTCGTAGTTTTGAAAACACTGCTGCTGACTGGCCGGAAATGCAAACGTTGGCTGGTGCTTTTGATTCAGACCGGTGG
GGCTTCCGGCCTCGCACGGTGGTTCTGCACGGAAAGTCAGGAATTGGGAAATCGGCTCTAGCCAGAAGGATCGTGCTGTGCTGGGCGCAA
GGTGGACTCTACCAGGGAATGTTCTCCTACGTCTTCTTCCTCCCCGTTAGAGAGATGCAGCGGAAGAAGGAGAGCAGTGTCACAGAGTTC
ATCTCCAGGGAGTGGCCAGACTCCCAGGCTCCGGTGACGGAGATCATGTCCCGACCAGAAAGGCTGTTGTTCATCATTGACGGTTTCGAT
GACCTGGGCTCTGTCCTCAACAATGACACAAAGCTCTGCAAAGACTGGGCTGAGAAGCAGCCTCCGTTCACCCTCATACGCAGTCTGCTG
AGGAAGGTCCTGCTCCCTGAGTCCTTCCTGATCGTCACCGTCAGAGACGTGGGCACAGAGAAGCTCAAGTCAGAGGTCGTGTCTCCCCGT
TACCTGTTAGTTAGAGGAATCTCCGGGGAACAAAGAATCCACTTGCTCCTTGAGCGCGGGATTGGTGAGCATCAGAAGACACAAGGGTTG
CGTGCGATCATGAACAACCGTGAGCTGCTCGACCAGTGCCAGGTGCCCGCCGTGGGCTCTCTCATCTGCGTGGCCCTGCAGCTGCAGGAC
GTGGTGGGGGAGAGCGTCGCCCCCTTCAACCAAACGCTCACAGGCCTGCACGCCGCTTTTGTGTTTCATCAGCTCACCCCTCGAGGCGTG
GTCCGGCGCTGTCTCAATCTGGAGGAAAGAGTTGTCCTGAAGCGCTTCTGCCGTATGGCTGTGGAGGGAGTGTGGAATAGGAAGTCAGTG
TTTGACGGTGACGACCTCATGGTTCAAGGACTCGGGGAGTCTGAGCTCCGTGCTCTGTTTCACATGAACATCCTTCTCCCAGACAGCCAC
TGTGAGGAGTACTACACCTTCTTCCACCTCAGTCTCCAGGACTTCTGTGCCGCCTTGTACTACGTGTTAGAGGGCCTGGAAATCGAGCCA
GCTCTCTGCCCTCTGTACGTTGAGAAGACAAAGAGGTCCATGGAGCTTAAACAGGCAGGCTTCCATATCCACTCGCTTTGGATGAAGCGT
TTCTTGTTTGGCCTCGTGAGCGAAGACGTAAGGAGGCCACTGGAGGTCCTGCTGGGCTGTCCCGTTCCCCTGGGGGTGAAGCAGAAGCTT
CTGCACTGGGTCTCTCTGTTGGGTCAGCAGCCTAATGCCACCACCCCAGGAGACACCCTGGACGCCTTCCACTGTCTTTTCGAGACTCAA
GACAAAGAGTTTGTTCGCTTGGCATTAAACAGCTTCCAAGAAGTGTGGCTTCCGATTAACCAGAACCTGGACTTGATAGCATCTTCCTTC
TGCCTCCAGCACTGTCCGTATTTGCGGAAAATTCGGGTGGATGTCAAAGGGATCTTCCCAAGAGATGAGTCCGCTGAGGCATGTCCTGTG
GTCCCTCTATGGATGCGGGATAAGACCCTCATTGAGGAGCAGTGGGAAGATTTCTGCTCCATGCTTGGCACCCACCCACACCTGCGGCAG
CTGGACCTGGGCAGCAGCATCCTGACAGAGCGGGCCATGAAGACCCTGTGTGCCAAGCTGAGGCATCCCACCTGCAAGATACAGACCCTG
ATGTTTAGAAATGCACAGATTACCCCTGGTGTGCAGCACCTCTGGAGAATCGTCATGGCCAACCGTAACCTAAGATCCCTCAACTTGGGA
GGCACCCACCTGAAGGAAGAGGATGTAAGGATGGCGTGTGAAGCCTTAAAACACCCAAAATGTTTGTTGGAGTCTTTGAGGCTGGATTGC
TGTGGATTGACCCATGCCTGTTACCTGAAGATCTCCCAAATCCTTACGACCTCCCCCAGCCTGAAATCTCTGAGCCTGGCAGGAAACAAG
GTGACAGACCAGGGAGTAATGCCTCTCAGTGATGCCTTGAGAGTCTCCCAGTGCGCCCTGCAGAAGCTGATACTGGAGGACTGTGGCATC
ACAGCCACGGGTTGCCAGAGTCTGGCCTCAGCCCTCGTCAGCAACCGGAGCTTGACACACCTGTGCCTATCCAACAACAGCCTGGGGAAC
GAAGGTGTAAATCTACTGTGTCGATCCATGAGGCTTCCCCACTGTAGTCTGCAGAGGCTGATGCTGAATCAGTGCCACCTGGACACGGCT
GGCTGTGGTTTTCTTGCACTTGCGCTTATGGGTAACTCATGGCTGACGCACCTGAGCCTTAGCATGAACCCTGTGGAAGACAATGGCGTG
AAGCTTCTGTGCGAGGTCATGAGAGAACCATCTTGTCATCTCCAGGACCTGGAGTTGGTAAAGTGTCATCTCACCGCCGCGTGCTGTGAG
AGTCTGTCCTGTGTGATCTCGAGGAGCAGACACCTGAAGAGCCTGGATCTCACGGACAATGCCCTGGGTGACGGTGGGGTTGCTGCGCTG
TGCGAGGGACTGAAGCAAAAGAACAGTGTTCTGGCGAGACTCGGGTTGAAGGCATGTGGACTGACTTCTGATTGCTGTGAGGCACTCTCC
TTGGCCCTTTCCTGCAACCGGCATCTGACCAGTCTAAACCTGGTGCAGAATAACTTCAGTCCCAAAGGAATGATGAAGCTGTGTTCGGCC
TTTGCCTGTCCCACGTCTAACTTACAGATAATTGGGCTGTGGAAATGGCAGTACCCTGTGCAAATAAGGAAGCTGCTGGAGGAAGTGCAG
CTACTCAAGCCCCGAGTCGTAATTGACGGTAGTTGGCATTCTTTTGATGAAGATGACCGGTACTGGTGGAAAAACTGAAGATACGGAAAC
CTGCCCCACTCACACCCATCTGATGGAGGAACTTTAAACGCTGTTTTCTCAGAGCAAGCTATGCACCTGGGAGTTCCTTCTCAAAGATGG
AGAATGATTTCTGATTCTCACAAAGCCCTCAATGGTAGTGATTCTTCTGTGTTCACTCTACGTTGGTTACTGGATTTGAAGGCTAGAGAC
CTTCAAGTCATAGGACTCAGTATCTGTGAAATGTCCGTCATATCTCAGAGCATATAGAGGGAATTAAATAAACACAAAGCATTTGGAAAA

>96404_96404_1_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000257468_NLRP5_chr19_56530707_ENST00000390649_length(amino acids)=1380AA_BP=387
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAF
DSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFI
IDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQ
KTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW
NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHS
LWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDL
IASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC
KIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLS
LAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQC
HLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDG
GVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKL

--------------------------------------------------------------
>96404_96404_2_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000257468_NLRP5_chr19_56531740_ENST00000390649_length(transcript)=4626nt_BP=1360nt
GCGGATGTCGGTGTGAGCGAGCGGCGCCTGAACACACGGCGGCTGCCGAGCGCCTGACCCGGGCCTGCGCCAGAGCCTGCACCGAGCTCC
GGGGCCCCACACCCGCTACGGTGGCCCTGCGCCCGTTGCTACTGAGGCGGCGTGCTCTGCATTCTTCGCTGTCCAGGCCTGCCGGCTCTG
GTGTCTGCTGGCTCCTCCTTGCTCGCCTGCTCCCTCCTGCTTGCCTGAGTCACCGCCGCCGCCGCCGCCACAGCCATGGCCGAGAGTGGT
GAAAGCGGCGGTCCTCCGGGCTCCCAGGATAGCGCCGCCGGAGCCGAAGGTGCTGGCGCCCCCGCGGCCGCTGCCTCCGCGGAGCCCAAA
ATCATGAAAGTCACCGTGAAGACCCCGAAGGAAAAGGAGGAATTCGCCGTGCCCGAGAATAGCTCCGTCCAGCAGTTTAAGGAAGAAATC
TCTAAACGTTTTAAATCACATACTGACCAACTTGTGTTGATATTTGCTGGAAAAATTTTGAAAGATCAAGATACCTTGAGTCAGCATGGA
ATTCATGATGGACTTACTGTTCACCTTGTCATTAAAACACAAAACAGGCCTCAGGATCATTCAGCTCAGCAAACAAATACAGCTGGAAGC
AATGTTACTACATCATCAACTCCTAATAGTAACTCTACATCTGGTTCTGCTACTAGCAACCCTTTTGGTTTAGGTGGCCTTGGGGGACTT
GCAGGTCTGAGTAGCTTGGGTTTGAATACTACCAACTTCTCTGAACTACAGAGTCAGATGCAGCGACAACTTTTGTCTAACCCTGAAATG
ATGGTCCAGATCATGGAAAATCCCTTTGTTCAGAGCATGCTCTCAAATCCTGACCTGATGAGACAGTTAATTATGGCCAATCCACAAATG
CAGCAGTTGATACAGAGAAATCCAGAAATTAGTCATATGTTGAATAATCCAGATATAATGAGACAAACGTTGGAACTTGCCAGGAATCCA
GCAATGATGCAGGAGATGATGAGGAACCAGGACCGAGCTTTGAGCAACCTAGAAAGCATCCCAGGGGGATATAATGCTTTAAGGCGCATG
TACACAGATATTCAGGAACCAATGCTGAGTGCTGCACAAGAGCAGTTTGGTGGTAATCCATTTGCTTCCTTGGTGAGCAATACATCCTCT
GGTGAAGGTAGTCAACCTTCCCGTACAGAAAATAGAGATCCACTACCCAATCCATGGGCTCCACAGACTTCCCAGAGTTCATCAGCTTCC
AGCGGCACTGCCAGCACTGTGGGTGGCACTACTGGTAGTACTGCCAGTGGCACTTCTGGGCAGAGTACTACTGCGCCAAATTTGGTGCCT
GGAGTAGGAGAAATTTCACAAGCTATGGAACAAGAAGGTGCCACAGCAGCAGAGACAGAAGAACAAGGACATGGAGGTGACACATGGGAC
TACAAGAGTCACGTGATGACCAAATTCGCTGAGGAGGAGGATGTACGTCGTAGTTTTGAAAACACTGCTGCTGACTGGCCGGAAATGCAA
ACGTTGGCTGGTGCTTTTGATTCAGACCGGTGGGGCTTCCGGCCTCGCACGGTGGTTCTGCACGGAAAGTCAGGAATTGGGAAATCGGCT
CTAGCCAGAAGGATCGTGCTGTGCTGGGCGCAAGGTGGACTCTACCAGGGAATGTTCTCCTACGTCTTCTTCCTCCCCGTTAGAGAGATG
CAGCGGAAGAAGGAGAGCAGTGTCACAGAGTTCATCTCCAGGGAGTGGCCAGACTCCCAGGCTCCGGTGACGGAGATCATGTCCCGACCA
GAAAGGCTGTTGTTCATCATTGACGGTTTCGATGACCTGGGCTCTGTCCTCAACAATGACACAAAGCTCTGCAAAGACTGGGCTGAGAAG
CAGCCTCCGTTCACCCTCATACGCAGTCTGCTGAGGAAGGTCCTGCTCCCTGAGTCCTTCCTGATCGTCACCGTCAGAGACGTGGGCACA
GAGAAGCTCAAGTCAGAGGTCGTGTCTCCCCGTTACCTGTTAGTTAGAGGAATCTCCGGGGAACAAAGAATCCACTTGCTCCTTGAGCGC
GGGATTGGTGAGCATCAGAAGACACAAGGGTTGCGTGCGATCATGAACAACCGTGAGCTGCTCGACCAGTGCCAGGTGCCCGCCGTGGGC
TCTCTCATCTGCGTGGCCCTGCAGCTGCAGGACGTGGTGGGGGAGAGCGTCGCCCCCTTCAACCAAACGCTCACAGGCCTGCACGCCGCT
TTTGTGTTTCATCAGCTCACCCCTCGAGGCGTGGTCCGGCGCTGTCTCAATCTGGAGGAAAGAGTTGTCCTGAAGCGCTTCTGCCGTATG
GCTGTGGAGGGAGTGTGGAATAGGAAGTCAGTGTTTGACGGTGACGACCTCATGGTTCAAGGACTCGGGGAGTCTGAGCTCCGTGCTCTG
TTTCACATGAACATCCTTCTCCCAGACAGCCACTGTGAGGAGTACTACACCTTCTTCCACCTCAGTCTCCAGGACTTCTGTGCCGCCTTG
TACTACGTGTTAGAGGGCCTGGAAATCGAGCCAGCTCTCTGCCCTCTGTACGTTGAGAAGACAAAGAGGTCCATGGAGCTTAAACAGGCA
GGCTTCCATATCCACTCGCTTTGGATGAAGCGTTTCTTGTTTGGCCTCGTGAGCGAAGACGTAAGGAGGCCACTGGAGGTCCTGCTGGGC
TGTCCCGTTCCCCTGGGGGTGAAGCAGAAGCTTCTGCACTGGGTCTCTCTGTTGGGTCAGCAGCCTAATGCCACCACCCCAGGAGACACC
CTGGACGCCTTCCACTGTCTTTTCGAGACTCAAGACAAAGAGTTTGTTCGCTTGGCATTAAACAGCTTCCAAGAAGTGTGGCTTCCGATT
AACCAGAACCTGGACTTGATAGCATCTTCCTTCTGCCTCCAGCACTGTCCGTATTTGCGGAAAATTCGGGTGGATGTCAAAGGGATCTTC
CCAAGAGATGAGTCCGCTGAGGCATGTCCTGTGGTCCCTCTATGGATGCGGGATAAGACCCTCATTGAGGAGCAGTGGGAAGATTTCTGC
TCCATGCTTGGCACCCACCCACACCTGCGGCAGCTGGACCTGGGCAGCAGCATCCTGACAGAGCGGGCCATGAAGACCCTGTGTGCCAAG
CTGAGGCATCCCACCTGCAAGATACAGACCCTGATGTTTAGAAATGCACAGATTACCCCTGGTGTGCAGCACCTCTGGAGAATCGTCATG
GCCAACCGTAACCTAAGATCCCTCAACTTGGGAGGCACCCACCTGAAGGAAGAGGATGTAAGGATGGCGTGTGAAGCCTTAAAACACCCA
AAATGTTTGTTGGAGTCTTTGAGGCTGGATTGCTGTGGATTGACCCATGCCTGTTACCTGAAGATCTCCCAAATCCTTACGACCTCCCCC
AGCCTGAAATCTCTGAGCCTGGCAGGAAACAAGGTGACAGACCAGGGAGTAATGCCTCTCAGTGATGCCTTGAGAGTCTCCCAGTGCGCC
CTGCAGAAGCTGATACTGGAGGACTGTGGCATCACAGCCACGGGTTGCCAGAGTCTGGCCTCAGCCCTCGTCAGCAACCGGAGCTTGACA
CACCTGTGCCTATCCAACAACAGCCTGGGGAACGAAGGTGTAAATCTACTGTGTCGATCCATGAGGCTTCCCCACTGTAGTCTGCAGAGG
CTGATGCTGAATCAGTGCCACCTGGACACGGCTGGCTGTGGTTTTCTTGCACTTGCGCTTATGGGTAACTCATGGCTGACGCACCTGAGC
CTTAGCATGAACCCTGTGGAAGACAATGGCGTGAAGCTTCTGTGCGAGGTCATGAGAGAACCATCTTGTCATCTCCAGGACCTGGAGTTG
GTAAAGTGTCATCTCACCGCCGCGTGCTGTGAGAGTCTGTCCTGTGTGATCTCGAGGAGCAGACACCTGAAGAGCCTGGATCTCACGGAC
AATGCCCTGGGTGACGGTGGGGTTGCTGCGCTGTGCGAGGGACTGAAGCAAAAGAACAGTGTTCTGGCGAGACTCGGGTTGAAGGCATGT
GGACTGACTTCTGATTGCTGTGAGGCACTCTCCTTGGCCCTTTCCTGCAACCGGCATCTGACCAGTCTAAACCTGGTGCAGAATAACTTC
AGTCCCAAAGGAATGATGAAGCTGTGTTCGGCCTTTGCCTGTCCCACGTCTAACTTACAGATAATTGGGCTGTGGAAATGGCAGTACCCT
GTGCAAATAAGGAAGCTGCTGGAGGAAGTGCAGCTACTCAAGCCCCGAGTCGTAATTGACGGTAGTTGGCATTCTTTTGATGAAGATGAC
CGGTACTGGTGGAAAAACTGAAGATACGGAAACCTGCCCCACTCACACCCATCTGATGGAGGAACTTTAAACGCTGTTTTCTCAGAGCAA
GCTATGCACCTGGGAGTTCCTTCTCAAAGATGGAGAATGATTTCTGATTCTCACAAAGCCCTCAATGGTAGTGATTCTTCTGTGTTCACT
CTACGTTGGTTACTGGATTTGAAGGCTAGAGACCTTCAAGTCATAGGACTCAGTATCTGTGAAATGTCCGTCATATCTCAGAGCATATAG

>96404_96404_2_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000257468_NLRP5_chr19_56531740_ENST00000390649_length(amino acids)=1361AA_BP=368
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSG
IGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCK
DWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQ
VPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGES
ELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPL
EVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVD
VKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHL
WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALR
VSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSW
LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARL
GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHS

--------------------------------------------------------------
>96404_96404_3_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000376395_NLRP5_chr19_56530707_ENST00000390649_length(transcript)=4952nt_BP=1629nt
GGAAACTGCGATTTAGTTTTTGGTGAAAGGAGTGGAAAAAAACCATGAACTGACCTACCCCGCCCCATTTTGCTTTTAGTCCTTCACACT
GGCTTCGCCTGCACTTTGGGCAATGGAGCGGGAAAGGAAAAGGCACGCAGGCTGAGCTCAAAGTCGCGCCAGCCGGGGATGACTCGGCGA
CGCCGCCAGGCGCGTTACCCGGCGTGCTCCGCGCGGCGCCGGCGAAGGGACGTGGGGGAAGGGGCAGGGAGGAGGAAGCGGTGGCTGCTG
CGGATGTCGGTGTGAGCGAGCGGCGCCTGAACACACGGCGGCTGCCGAGCGCCTGACCCGGGCCTGCGCCAGAGCCTGCACCGAGCTCCG
GGGCCCCACACCCGCTACGGTGGCCCTGCGCCCGTTGCTACTGAGGCGGCGTGCTCTGCATTCTTCGCTGTCCAGGCCTGCCGGCTCTGG
TGTCTGCTGGCTCCTCCTTGCTCGCCTGCTCCCTCCTGCTTGCCTGAGTCACCGCCGCCGCCGCCGCCACAGCCATGGCCGAGAGTGGTG
AAAGCGGCGGTCCTCCGGGCTCCCAGGATAGCGCCGCCGGAGCCGAAGGTGCTGGCGCCCCCGCGGCCGCTGCCTCCGCGGAGCCCAAAA
TCATGAAAGTCACCGTGAAGACCCCGAAGGAAAAGGAGGAATTCGCCGTGCCCGAGAATAGCTCCGTCCAGCAGTTTAAGGAAGAAATCT
CTAAACGTTTTAAATCACATACTGACCAACTTGTGTTGATATTTGCTGGAAAAATTTTGAAAGATCAAGATACCTTGAGTCAGCATGGAA
TTCATGATGGACTTACTGTTCACCTTGTCATTAAAACACAAAACAGGCCTCAGGATCATTCAGCTCAGCAAACAAATACAGCTGGAAGCA
ATGTTACTACATCATCAACTCCTAATAGTAACTCTACATCTGGTTCTGCTACTAGCAACCCTTTTGGTTTAGGTGGCCTTGGGGGACTTG
CAGGTCTGAGTAGCTTGGGTTTGAATACTACCAACTTCTCTGAACTACAGAGTCAGATGCAGCGACAACTTTTGTCTAACCCTGAAATGA
TGGTCCAGATCATGGAAAATCCCTTTGTTCAGAGCATGCTCTCAAATCCTGACCTGATGAGACAGTTAATTATGGCCAATCCACAAATGC
AGCAGTTGATACAGAGAAATCCAGAAATTAGTCATATGTTGAATAATCCAGATATAATGAGACAAACGTTGGAACTTGCCAGGAATCCAG
CAATGATGCAGGAGATGATGAGGAACCAGGACCGAGCTTTGAGCAACCTAGAAAGCATCCCAGGGGGATATAATGCTTTAAGGCGCATGT
ACACAGATATTCAGGAACCAATGCTGAGTGCTGCACAAGAGCAGTTTGGTGGTAATCCATTTGCTTCCTTGGTGAGCAATACATCCTCTG
GTGAAGGTAGTCAACCTTCCCGTACAGAAAATAGAGATCCACTACCCAATCCATGGGCTCCACAGACTTCCCAGAGTTCATCAGCTTCCA
GCGGCACTGCCAGCACTGTGGGTGGCACTACTGGTAGTACTGCCAGTGGCACTTCTGGGCAGAGTACTACTGCGCCAAATTTGGTGCCTG
GAGTAGGAGAAATTTCACAAGCTATGGAACAAGAAGGTGCCACAGCAGCAGAGACAGAAGAACAAGAAATTTCACAAGCTATGGAACAAG
AAGGTGCCACAGCAGCAGAGACAGAAGAACAAGGACATGGAGGTGACACATGGGACTACAAGAGTCACGTGATGACCAAATTCGCTGAGG
AGGAGGATGTACGTCGTAGTTTTGAAAACACTGCTGCTGACTGGCCGGAAATGCAAACGTTGGCTGGTGCTTTTGATTCAGACCGGTGGG
GCTTCCGGCCTCGCACGGTGGTTCTGCACGGAAAGTCAGGAATTGGGAAATCGGCTCTAGCCAGAAGGATCGTGCTGTGCTGGGCGCAAG
GTGGACTCTACCAGGGAATGTTCTCCTACGTCTTCTTCCTCCCCGTTAGAGAGATGCAGCGGAAGAAGGAGAGCAGTGTCACAGAGTTCA
TCTCCAGGGAGTGGCCAGACTCCCAGGCTCCGGTGACGGAGATCATGTCCCGACCAGAAAGGCTGTTGTTCATCATTGACGGTTTCGATG
ACCTGGGCTCTGTCCTCAACAATGACACAAAGCTCTGCAAAGACTGGGCTGAGAAGCAGCCTCCGTTCACCCTCATACGCAGTCTGCTGA
GGAAGGTCCTGCTCCCTGAGTCCTTCCTGATCGTCACCGTCAGAGACGTGGGCACAGAGAAGCTCAAGTCAGAGGTCGTGTCTCCCCGTT
ACCTGTTAGTTAGAGGAATCTCCGGGGAACAAAGAATCCACTTGCTCCTTGAGCGCGGGATTGGTGAGCATCAGAAGACACAAGGGTTGC
GTGCGATCATGAACAACCGTGAGCTGCTCGACCAGTGCCAGGTGCCCGCCGTGGGCTCTCTCATCTGCGTGGCCCTGCAGCTGCAGGACG
TGGTGGGGGAGAGCGTCGCCCCCTTCAACCAAACGCTCACAGGCCTGCACGCCGCTTTTGTGTTTCATCAGCTCACCCCTCGAGGCGTGG
TCCGGCGCTGTCTCAATCTGGAGGAAAGAGTTGTCCTGAAGCGCTTCTGCCGTATGGCTGTGGAGGGAGTGTGGAATAGGAAGTCAGTGT
TTGACGGTGACGACCTCATGGTTCAAGGACTCGGGGAGTCTGAGCTCCGTGCTCTGTTTCACATGAACATCCTTCTCCCAGACAGCCACT
GTGAGGAGTACTACACCTTCTTCCACCTCAGTCTCCAGGACTTCTGTGCCGCCTTGTACTACGTGTTAGAGGGCCTGGAAATCGAGCCAG
CTCTCTGCCCTCTGTACGTTGAGAAGACAAAGAGGTCCATGGAGCTTAAACAGGCAGGCTTCCATATCCACTCGCTTTGGATGAAGCGTT
TCTTGTTTGGCCTCGTGAGCGAAGACGTAAGGAGGCCACTGGAGGTCCTGCTGGGCTGTCCCGTTCCCCTGGGGGTGAAGCAGAAGCTTC
TGCACTGGGTCTCTCTGTTGGGTCAGCAGCCTAATGCCACCACCCCAGGAGACACCCTGGACGCCTTCCACTGTCTTTTCGAGACTCAAG
ACAAAGAGTTTGTTCGCTTGGCATTAAACAGCTTCCAAGAAGTGTGGCTTCCGATTAACCAGAACCTGGACTTGATAGCATCTTCCTTCT
GCCTCCAGCACTGTCCGTATTTGCGGAAAATTCGGGTGGATGTCAAAGGGATCTTCCCAAGAGATGAGTCCGCTGAGGCATGTCCTGTGG
TCCCTCTATGGATGCGGGATAAGACCCTCATTGAGGAGCAGTGGGAAGATTTCTGCTCCATGCTTGGCACCCACCCACACCTGCGGCAGC
TGGACCTGGGCAGCAGCATCCTGACAGAGCGGGCCATGAAGACCCTGTGTGCCAAGCTGAGGCATCCCACCTGCAAGATACAGACCCTGA
TGTTTAGAAATGCACAGATTACCCCTGGTGTGCAGCACCTCTGGAGAATCGTCATGGCCAACCGTAACCTAAGATCCCTCAACTTGGGAG
GCACCCACCTGAAGGAAGAGGATGTAAGGATGGCGTGTGAAGCCTTAAAACACCCAAAATGTTTGTTGGAGTCTTTGAGGCTGGATTGCT
GTGGATTGACCCATGCCTGTTACCTGAAGATCTCCCAAATCCTTACGACCTCCCCCAGCCTGAAATCTCTGAGCCTGGCAGGAAACAAGG
TGACAGACCAGGGAGTAATGCCTCTCAGTGATGCCTTGAGAGTCTCCCAGTGCGCCCTGCAGAAGCTGATACTGGAGGACTGTGGCATCA
CAGCCACGGGTTGCCAGAGTCTGGCCTCAGCCCTCGTCAGCAACCGGAGCTTGACACACCTGTGCCTATCCAACAACAGCCTGGGGAACG
AAGGTGTAAATCTACTGTGTCGATCCATGAGGCTTCCCCACTGTAGTCTGCAGAGGCTGATGCTGAATCAGTGCCACCTGGACACGGCTG
GCTGTGGTTTTCTTGCACTTGCGCTTATGGGTAACTCATGGCTGACGCACCTGAGCCTTAGCATGAACCCTGTGGAAGACAATGGCGTGA
AGCTTCTGTGCGAGGTCATGAGAGAACCATCTTGTCATCTCCAGGACCTGGAGTTGGTAAAGTGTCATCTCACCGCCGCGTGCTGTGAGA
GTCTGTCCTGTGTGATCTCGAGGAGCAGACACCTGAAGAGCCTGGATCTCACGGACAATGCCCTGGGTGACGGTGGGGTTGCTGCGCTGT
GCGAGGGACTGAAGCAAAAGAACAGTGTTCTGGCGAGACTCGGGTTGAAGGCATGTGGACTGACTTCTGATTGCTGTGAGGCACTCTCCT
TGGCCCTTTCCTGCAACCGGCATCTGACCAGTCTAAACCTGGTGCAGAATAACTTCAGTCCCAAAGGAATGATGAAGCTGTGTTCGGCCT
TTGCCTGTCCCACGTCTAACTTACAGATAATTGGGCTGTGGAAATGGCAGTACCCTGTGCAAATAAGGAAGCTGCTGGAGGAAGTGCAGC
TACTCAAGCCCCGAGTCGTAATTGACGGTAGTTGGCATTCTTTTGATGAAGATGACCGGTACTGGTGGAAAAACTGAAGATACGGAAACC
TGCCCCACTCACACCCATCTGATGGAGGAACTTTAAACGCTGTTTTCTCAGAGCAAGCTATGCACCTGGGAGTTCCTTCTCAAAGATGGA
GAATGATTTCTGATTCTCACAAAGCCCTCAATGGTAGTGATTCTTCTGTGTTCACTCTACGTTGGTTACTGGATTTGAAGGCTAGAGACC
TTCAAGTCATAGGACTCAGTATCTGTGAAATGTCCGTCATATCTCAGAGCATATAGAGGGAATTAAATAAACACAAAGCATTTGGAAAAG

>96404_96404_3_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000376395_NLRP5_chr19_56530707_ENST00000390649_length(amino acids)=1380AA_BP=387
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAF
DSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFI
IDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQ
KTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW
NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHS
LWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDL
IASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC
KIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLS
LAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQC
HLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDG
GVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKL

--------------------------------------------------------------
>96404_96404_4_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000376395_NLRP5_chr19_56531740_ENST00000390649_length(transcript)=4895nt_BP=1629nt
GGAAACTGCGATTTAGTTTTTGGTGAAAGGAGTGGAAAAAAACCATGAACTGACCTACCCCGCCCCATTTTGCTTTTAGTCCTTCACACT
GGCTTCGCCTGCACTTTGGGCAATGGAGCGGGAAAGGAAAAGGCACGCAGGCTGAGCTCAAAGTCGCGCCAGCCGGGGATGACTCGGCGA
CGCCGCCAGGCGCGTTACCCGGCGTGCTCCGCGCGGCGCCGGCGAAGGGACGTGGGGGAAGGGGCAGGGAGGAGGAAGCGGTGGCTGCTG
CGGATGTCGGTGTGAGCGAGCGGCGCCTGAACACACGGCGGCTGCCGAGCGCCTGACCCGGGCCTGCGCCAGAGCCTGCACCGAGCTCCG
GGGCCCCACACCCGCTACGGTGGCCCTGCGCCCGTTGCTACTGAGGCGGCGTGCTCTGCATTCTTCGCTGTCCAGGCCTGCCGGCTCTGG
TGTCTGCTGGCTCCTCCTTGCTCGCCTGCTCCCTCCTGCTTGCCTGAGTCACCGCCGCCGCCGCCGCCACAGCCATGGCCGAGAGTGGTG
AAAGCGGCGGTCCTCCGGGCTCCCAGGATAGCGCCGCCGGAGCCGAAGGTGCTGGCGCCCCCGCGGCCGCTGCCTCCGCGGAGCCCAAAA
TCATGAAAGTCACCGTGAAGACCCCGAAGGAAAAGGAGGAATTCGCCGTGCCCGAGAATAGCTCCGTCCAGCAGTTTAAGGAAGAAATCT
CTAAACGTTTTAAATCACATACTGACCAACTTGTGTTGATATTTGCTGGAAAAATTTTGAAAGATCAAGATACCTTGAGTCAGCATGGAA
TTCATGATGGACTTACTGTTCACCTTGTCATTAAAACACAAAACAGGCCTCAGGATCATTCAGCTCAGCAAACAAATACAGCTGGAAGCA
ATGTTACTACATCATCAACTCCTAATAGTAACTCTACATCTGGTTCTGCTACTAGCAACCCTTTTGGTTTAGGTGGCCTTGGGGGACTTG
CAGGTCTGAGTAGCTTGGGTTTGAATACTACCAACTTCTCTGAACTACAGAGTCAGATGCAGCGACAACTTTTGTCTAACCCTGAAATGA
TGGTCCAGATCATGGAAAATCCCTTTGTTCAGAGCATGCTCTCAAATCCTGACCTGATGAGACAGTTAATTATGGCCAATCCACAAATGC
AGCAGTTGATACAGAGAAATCCAGAAATTAGTCATATGTTGAATAATCCAGATATAATGAGACAAACGTTGGAACTTGCCAGGAATCCAG
CAATGATGCAGGAGATGATGAGGAACCAGGACCGAGCTTTGAGCAACCTAGAAAGCATCCCAGGGGGATATAATGCTTTAAGGCGCATGT
ACACAGATATTCAGGAACCAATGCTGAGTGCTGCACAAGAGCAGTTTGGTGGTAATCCATTTGCTTCCTTGGTGAGCAATACATCCTCTG
GTGAAGGTAGTCAACCTTCCCGTACAGAAAATAGAGATCCACTACCCAATCCATGGGCTCCACAGACTTCCCAGAGTTCATCAGCTTCCA
GCGGCACTGCCAGCACTGTGGGTGGCACTACTGGTAGTACTGCCAGTGGCACTTCTGGGCAGAGTACTACTGCGCCAAATTTGGTGCCTG
GAGTAGGAGAAATTTCACAAGCTATGGAACAAGAAGGTGCCACAGCAGCAGAGACAGAAGAACAAGGACATGGAGGTGACACATGGGACT
ACAAGAGTCACGTGATGACCAAATTCGCTGAGGAGGAGGATGTACGTCGTAGTTTTGAAAACACTGCTGCTGACTGGCCGGAAATGCAAA
CGTTGGCTGGTGCTTTTGATTCAGACCGGTGGGGCTTCCGGCCTCGCACGGTGGTTCTGCACGGAAAGTCAGGAATTGGGAAATCGGCTC
TAGCCAGAAGGATCGTGCTGTGCTGGGCGCAAGGTGGACTCTACCAGGGAATGTTCTCCTACGTCTTCTTCCTCCCCGTTAGAGAGATGC
AGCGGAAGAAGGAGAGCAGTGTCACAGAGTTCATCTCCAGGGAGTGGCCAGACTCCCAGGCTCCGGTGACGGAGATCATGTCCCGACCAG
AAAGGCTGTTGTTCATCATTGACGGTTTCGATGACCTGGGCTCTGTCCTCAACAATGACACAAAGCTCTGCAAAGACTGGGCTGAGAAGC
AGCCTCCGTTCACCCTCATACGCAGTCTGCTGAGGAAGGTCCTGCTCCCTGAGTCCTTCCTGATCGTCACCGTCAGAGACGTGGGCACAG
AGAAGCTCAAGTCAGAGGTCGTGTCTCCCCGTTACCTGTTAGTTAGAGGAATCTCCGGGGAACAAAGAATCCACTTGCTCCTTGAGCGCG
GGATTGGTGAGCATCAGAAGACACAAGGGTTGCGTGCGATCATGAACAACCGTGAGCTGCTCGACCAGTGCCAGGTGCCCGCCGTGGGCT
CTCTCATCTGCGTGGCCCTGCAGCTGCAGGACGTGGTGGGGGAGAGCGTCGCCCCCTTCAACCAAACGCTCACAGGCCTGCACGCCGCTT
TTGTGTTTCATCAGCTCACCCCTCGAGGCGTGGTCCGGCGCTGTCTCAATCTGGAGGAAAGAGTTGTCCTGAAGCGCTTCTGCCGTATGG
CTGTGGAGGGAGTGTGGAATAGGAAGTCAGTGTTTGACGGTGACGACCTCATGGTTCAAGGACTCGGGGAGTCTGAGCTCCGTGCTCTGT
TTCACATGAACATCCTTCTCCCAGACAGCCACTGTGAGGAGTACTACACCTTCTTCCACCTCAGTCTCCAGGACTTCTGTGCCGCCTTGT
ACTACGTGTTAGAGGGCCTGGAAATCGAGCCAGCTCTCTGCCCTCTGTACGTTGAGAAGACAAAGAGGTCCATGGAGCTTAAACAGGCAG
GCTTCCATATCCACTCGCTTTGGATGAAGCGTTTCTTGTTTGGCCTCGTGAGCGAAGACGTAAGGAGGCCACTGGAGGTCCTGCTGGGCT
GTCCCGTTCCCCTGGGGGTGAAGCAGAAGCTTCTGCACTGGGTCTCTCTGTTGGGTCAGCAGCCTAATGCCACCACCCCAGGAGACACCC
TGGACGCCTTCCACTGTCTTTTCGAGACTCAAGACAAAGAGTTTGTTCGCTTGGCATTAAACAGCTTCCAAGAAGTGTGGCTTCCGATTA
ACCAGAACCTGGACTTGATAGCATCTTCCTTCTGCCTCCAGCACTGTCCGTATTTGCGGAAAATTCGGGTGGATGTCAAAGGGATCTTCC
CAAGAGATGAGTCCGCTGAGGCATGTCCTGTGGTCCCTCTATGGATGCGGGATAAGACCCTCATTGAGGAGCAGTGGGAAGATTTCTGCT
CCATGCTTGGCACCCACCCACACCTGCGGCAGCTGGACCTGGGCAGCAGCATCCTGACAGAGCGGGCCATGAAGACCCTGTGTGCCAAGC
TGAGGCATCCCACCTGCAAGATACAGACCCTGATGTTTAGAAATGCACAGATTACCCCTGGTGTGCAGCACCTCTGGAGAATCGTCATGG
CCAACCGTAACCTAAGATCCCTCAACTTGGGAGGCACCCACCTGAAGGAAGAGGATGTAAGGATGGCGTGTGAAGCCTTAAAACACCCAA
AATGTTTGTTGGAGTCTTTGAGGCTGGATTGCTGTGGATTGACCCATGCCTGTTACCTGAAGATCTCCCAAATCCTTACGACCTCCCCCA
GCCTGAAATCTCTGAGCCTGGCAGGAAACAAGGTGACAGACCAGGGAGTAATGCCTCTCAGTGATGCCTTGAGAGTCTCCCAGTGCGCCC
TGCAGAAGCTGATACTGGAGGACTGTGGCATCACAGCCACGGGTTGCCAGAGTCTGGCCTCAGCCCTCGTCAGCAACCGGAGCTTGACAC
ACCTGTGCCTATCCAACAACAGCCTGGGGAACGAAGGTGTAAATCTACTGTGTCGATCCATGAGGCTTCCCCACTGTAGTCTGCAGAGGC
TGATGCTGAATCAGTGCCACCTGGACACGGCTGGCTGTGGTTTTCTTGCACTTGCGCTTATGGGTAACTCATGGCTGACGCACCTGAGCC
TTAGCATGAACCCTGTGGAAGACAATGGCGTGAAGCTTCTGTGCGAGGTCATGAGAGAACCATCTTGTCATCTCCAGGACCTGGAGTTGG
TAAAGTGTCATCTCACCGCCGCGTGCTGTGAGAGTCTGTCCTGTGTGATCTCGAGGAGCAGACACCTGAAGAGCCTGGATCTCACGGACA
ATGCCCTGGGTGACGGTGGGGTTGCTGCGCTGTGCGAGGGACTGAAGCAAAAGAACAGTGTTCTGGCGAGACTCGGGTTGAAGGCATGTG
GACTGACTTCTGATTGCTGTGAGGCACTCTCCTTGGCCCTTTCCTGCAACCGGCATCTGACCAGTCTAAACCTGGTGCAGAATAACTTCA
GTCCCAAAGGAATGATGAAGCTGTGTTCGGCCTTTGCCTGTCCCACGTCTAACTTACAGATAATTGGGCTGTGGAAATGGCAGTACCCTG
TGCAAATAAGGAAGCTGCTGGAGGAAGTGCAGCTACTCAAGCCCCGAGTCGTAATTGACGGTAGTTGGCATTCTTTTGATGAAGATGACC
GGTACTGGTGGAAAAACTGAAGATACGGAAACCTGCCCCACTCACACCCATCTGATGGAGGAACTTTAAACGCTGTTTTCTCAGAGCAAG
CTATGCACCTGGGAGTTCCTTCTCAAAGATGGAGAATGATTTCTGATTCTCACAAAGCCCTCAATGGTAGTGATTCTTCTGTGTTCACTC
TACGTTGGTTACTGGATTTGAAGGCTAGAGACCTTCAAGTCATAGGACTCAGTATCTGTGAAATGTCCGTCATATCTCAGAGCATATAGA

>96404_96404_4_UBQLN1-NLRP5_UBQLN1_chr9_86292641_ENST00000376395_NLRP5_chr19_56531740_ENST00000390649_length(amino acids)=1361AA_BP=368
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSG
IGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCK
DWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQ
VPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGES
ELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPL
EVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVD
VKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHL
WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALR
VSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSW
LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARL
GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHS

--------------------------------------------------------------
>96404_96404_5_UBQLN1-NLRP5_UBQLN1_chr9_86292642_ENST00000257468_NLRP5_chr19_56531741_ENST00000390649_length(transcript)=4626nt_BP=1360nt
GCGGATGTCGGTGTGAGCGAGCGGCGCCTGAACACACGGCGGCTGCCGAGCGCCTGACCCGGGCCTGCGCCAGAGCCTGCACCGAGCTCC
GGGGCCCCACACCCGCTACGGTGGCCCTGCGCCCGTTGCTACTGAGGCGGCGTGCTCTGCATTCTTCGCTGTCCAGGCCTGCCGGCTCTG
GTGTCTGCTGGCTCCTCCTTGCTCGCCTGCTCCCTCCTGCTTGCCTGAGTCACCGCCGCCGCCGCCGCCACAGCCATGGCCGAGAGTGGT
GAAAGCGGCGGTCCTCCGGGCTCCCAGGATAGCGCCGCCGGAGCCGAAGGTGCTGGCGCCCCCGCGGCCGCTGCCTCCGCGGAGCCCAAA
ATCATGAAAGTCACCGTGAAGACCCCGAAGGAAAAGGAGGAATTCGCCGTGCCCGAGAATAGCTCCGTCCAGCAGTTTAAGGAAGAAATC
TCTAAACGTTTTAAATCACATACTGACCAACTTGTGTTGATATTTGCTGGAAAAATTTTGAAAGATCAAGATACCTTGAGTCAGCATGGA
ATTCATGATGGACTTACTGTTCACCTTGTCATTAAAACACAAAACAGGCCTCAGGATCATTCAGCTCAGCAAACAAATACAGCTGGAAGC
AATGTTACTACATCATCAACTCCTAATAGTAACTCTACATCTGGTTCTGCTACTAGCAACCCTTTTGGTTTAGGTGGCCTTGGGGGACTT
GCAGGTCTGAGTAGCTTGGGTTTGAATACTACCAACTTCTCTGAACTACAGAGTCAGATGCAGCGACAACTTTTGTCTAACCCTGAAATG
ATGGTCCAGATCATGGAAAATCCCTTTGTTCAGAGCATGCTCTCAAATCCTGACCTGATGAGACAGTTAATTATGGCCAATCCACAAATG
CAGCAGTTGATACAGAGAAATCCAGAAATTAGTCATATGTTGAATAATCCAGATATAATGAGACAAACGTTGGAACTTGCCAGGAATCCA
GCAATGATGCAGGAGATGATGAGGAACCAGGACCGAGCTTTGAGCAACCTAGAAAGCATCCCAGGGGGATATAATGCTTTAAGGCGCATG
TACACAGATATTCAGGAACCAATGCTGAGTGCTGCACAAGAGCAGTTTGGTGGTAATCCATTTGCTTCCTTGGTGAGCAATACATCCTCT
GGTGAAGGTAGTCAACCTTCCCGTACAGAAAATAGAGATCCACTACCCAATCCATGGGCTCCACAGACTTCCCAGAGTTCATCAGCTTCC
AGCGGCACTGCCAGCACTGTGGGTGGCACTACTGGTAGTACTGCCAGTGGCACTTCTGGGCAGAGTACTACTGCGCCAAATTTGGTGCCT
GGAGTAGGAGAAATTTCACAAGCTATGGAACAAGAAGGTGCCACAGCAGCAGAGACAGAAGAACAAGGACATGGAGGTGACACATGGGAC
TACAAGAGTCACGTGATGACCAAATTCGCTGAGGAGGAGGATGTACGTCGTAGTTTTGAAAACACTGCTGCTGACTGGCCGGAAATGCAA
ACGTTGGCTGGTGCTTTTGATTCAGACCGGTGGGGCTTCCGGCCTCGCACGGTGGTTCTGCACGGAAAGTCAGGAATTGGGAAATCGGCT
CTAGCCAGAAGGATCGTGCTGTGCTGGGCGCAAGGTGGACTCTACCAGGGAATGTTCTCCTACGTCTTCTTCCTCCCCGTTAGAGAGATG
CAGCGGAAGAAGGAGAGCAGTGTCACAGAGTTCATCTCCAGGGAGTGGCCAGACTCCCAGGCTCCGGTGACGGAGATCATGTCCCGACCA
GAAAGGCTGTTGTTCATCATTGACGGTTTCGATGACCTGGGCTCTGTCCTCAACAATGACACAAAGCTCTGCAAAGACTGGGCTGAGAAG
CAGCCTCCGTTCACCCTCATACGCAGTCTGCTGAGGAAGGTCCTGCTCCCTGAGTCCTTCCTGATCGTCACCGTCAGAGACGTGGGCACA
GAGAAGCTCAAGTCAGAGGTCGTGTCTCCCCGTTACCTGTTAGTTAGAGGAATCTCCGGGGAACAAAGAATCCACTTGCTCCTTGAGCGC
GGGATTGGTGAGCATCAGAAGACACAAGGGTTGCGTGCGATCATGAACAACCGTGAGCTGCTCGACCAGTGCCAGGTGCCCGCCGTGGGC
TCTCTCATCTGCGTGGCCCTGCAGCTGCAGGACGTGGTGGGGGAGAGCGTCGCCCCCTTCAACCAAACGCTCACAGGCCTGCACGCCGCT
TTTGTGTTTCATCAGCTCACCCCTCGAGGCGTGGTCCGGCGCTGTCTCAATCTGGAGGAAAGAGTTGTCCTGAAGCGCTTCTGCCGTATG
GCTGTGGAGGGAGTGTGGAATAGGAAGTCAGTGTTTGACGGTGACGACCTCATGGTTCAAGGACTCGGGGAGTCTGAGCTCCGTGCTCTG
TTTCACATGAACATCCTTCTCCCAGACAGCCACTGTGAGGAGTACTACACCTTCTTCCACCTCAGTCTCCAGGACTTCTGTGCCGCCTTG
TACTACGTGTTAGAGGGCCTGGAAATCGAGCCAGCTCTCTGCCCTCTGTACGTTGAGAAGACAAAGAGGTCCATGGAGCTTAAACAGGCA
GGCTTCCATATCCACTCGCTTTGGATGAAGCGTTTCTTGTTTGGCCTCGTGAGCGAAGACGTAAGGAGGCCACTGGAGGTCCTGCTGGGC
TGTCCCGTTCCCCTGGGGGTGAAGCAGAAGCTTCTGCACTGGGTCTCTCTGTTGGGTCAGCAGCCTAATGCCACCACCCCAGGAGACACC
CTGGACGCCTTCCACTGTCTTTTCGAGACTCAAGACAAAGAGTTTGTTCGCTTGGCATTAAACAGCTTCCAAGAAGTGTGGCTTCCGATT
AACCAGAACCTGGACTTGATAGCATCTTCCTTCTGCCTCCAGCACTGTCCGTATTTGCGGAAAATTCGGGTGGATGTCAAAGGGATCTTC
CCAAGAGATGAGTCCGCTGAGGCATGTCCTGTGGTCCCTCTATGGATGCGGGATAAGACCCTCATTGAGGAGCAGTGGGAAGATTTCTGC
TCCATGCTTGGCACCCACCCACACCTGCGGCAGCTGGACCTGGGCAGCAGCATCCTGACAGAGCGGGCCATGAAGACCCTGTGTGCCAAG
CTGAGGCATCCCACCTGCAAGATACAGACCCTGATGTTTAGAAATGCACAGATTACCCCTGGTGTGCAGCACCTCTGGAGAATCGTCATG
GCCAACCGTAACCTAAGATCCCTCAACTTGGGAGGCACCCACCTGAAGGAAGAGGATGTAAGGATGGCGTGTGAAGCCTTAAAACACCCA
AAATGTTTGTTGGAGTCTTTGAGGCTGGATTGCTGTGGATTGACCCATGCCTGTTACCTGAAGATCTCCCAAATCCTTACGACCTCCCCC
AGCCTGAAATCTCTGAGCCTGGCAGGAAACAAGGTGACAGACCAGGGAGTAATGCCTCTCAGTGATGCCTTGAGAGTCTCCCAGTGCGCC
CTGCAGAAGCTGATACTGGAGGACTGTGGCATCACAGCCACGGGTTGCCAGAGTCTGGCCTCAGCCCTCGTCAGCAACCGGAGCTTGACA
CACCTGTGCCTATCCAACAACAGCCTGGGGAACGAAGGTGTAAATCTACTGTGTCGATCCATGAGGCTTCCCCACTGTAGTCTGCAGAGG
CTGATGCTGAATCAGTGCCACCTGGACACGGCTGGCTGTGGTTTTCTTGCACTTGCGCTTATGGGTAACTCATGGCTGACGCACCTGAGC
CTTAGCATGAACCCTGTGGAAGACAATGGCGTGAAGCTTCTGTGCGAGGTCATGAGAGAACCATCTTGTCATCTCCAGGACCTGGAGTTG
GTAAAGTGTCATCTCACCGCCGCGTGCTGTGAGAGTCTGTCCTGTGTGATCTCGAGGAGCAGACACCTGAAGAGCCTGGATCTCACGGAC
AATGCCCTGGGTGACGGTGGGGTTGCTGCGCTGTGCGAGGGACTGAAGCAAAAGAACAGTGTTCTGGCGAGACTCGGGTTGAAGGCATGT
GGACTGACTTCTGATTGCTGTGAGGCACTCTCCTTGGCCCTTTCCTGCAACCGGCATCTGACCAGTCTAAACCTGGTGCAGAATAACTTC
AGTCCCAAAGGAATGATGAAGCTGTGTTCGGCCTTTGCCTGTCCCACGTCTAACTTACAGATAATTGGGCTGTGGAAATGGCAGTACCCT
GTGCAAATAAGGAAGCTGCTGGAGGAAGTGCAGCTACTCAAGCCCCGAGTCGTAATTGACGGTAGTTGGCATTCTTTTGATGAAGATGAC
CGGTACTGGTGGAAAAACTGAAGATACGGAAACCTGCCCCACTCACACCCATCTGATGGAGGAACTTTAAACGCTGTTTTCTCAGAGCAA
GCTATGCACCTGGGAGTTCCTTCTCAAAGATGGAGAATGATTTCTGATTCTCACAAAGCCCTCAATGGTAGTGATTCTTCTGTGTTCACT
CTACGTTGGTTACTGGATTTGAAGGCTAGAGACCTTCAAGTCATAGGACTCAGTATCTGTGAAATGTCCGTCATATCTCAGAGCATATAG

>96404_96404_5_UBQLN1-NLRP5_UBQLN1_chr9_86292642_ENST00000257468_NLRP5_chr19_56531741_ENST00000390649_length(amino acids)=1361AA_BP=368
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSG
IGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCK
DWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQ
VPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGES
ELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPL
EVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVD
VKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHL
WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALR
VSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSW
LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARL
GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHS

--------------------------------------------------------------
>96404_96404_6_UBQLN1-NLRP5_UBQLN1_chr9_86292642_ENST00000376395_NLRP5_chr19_56531741_ENST00000390649_length(transcript)=4895nt_BP=1629nt
GGAAACTGCGATTTAGTTTTTGGTGAAAGGAGTGGAAAAAAACCATGAACTGACCTACCCCGCCCCATTTTGCTTTTAGTCCTTCACACT
GGCTTCGCCTGCACTTTGGGCAATGGAGCGGGAAAGGAAAAGGCACGCAGGCTGAGCTCAAAGTCGCGCCAGCCGGGGATGACTCGGCGA
CGCCGCCAGGCGCGTTACCCGGCGTGCTCCGCGCGGCGCCGGCGAAGGGACGTGGGGGAAGGGGCAGGGAGGAGGAAGCGGTGGCTGCTG
CGGATGTCGGTGTGAGCGAGCGGCGCCTGAACACACGGCGGCTGCCGAGCGCCTGACCCGGGCCTGCGCCAGAGCCTGCACCGAGCTCCG
GGGCCCCACACCCGCTACGGTGGCCCTGCGCCCGTTGCTACTGAGGCGGCGTGCTCTGCATTCTTCGCTGTCCAGGCCTGCCGGCTCTGG
TGTCTGCTGGCTCCTCCTTGCTCGCCTGCTCCCTCCTGCTTGCCTGAGTCACCGCCGCCGCCGCCGCCACAGCCATGGCCGAGAGTGGTG
AAAGCGGCGGTCCTCCGGGCTCCCAGGATAGCGCCGCCGGAGCCGAAGGTGCTGGCGCCCCCGCGGCCGCTGCCTCCGCGGAGCCCAAAA
TCATGAAAGTCACCGTGAAGACCCCGAAGGAAAAGGAGGAATTCGCCGTGCCCGAGAATAGCTCCGTCCAGCAGTTTAAGGAAGAAATCT
CTAAACGTTTTAAATCACATACTGACCAACTTGTGTTGATATTTGCTGGAAAAATTTTGAAAGATCAAGATACCTTGAGTCAGCATGGAA
TTCATGATGGACTTACTGTTCACCTTGTCATTAAAACACAAAACAGGCCTCAGGATCATTCAGCTCAGCAAACAAATACAGCTGGAAGCA
ATGTTACTACATCATCAACTCCTAATAGTAACTCTACATCTGGTTCTGCTACTAGCAACCCTTTTGGTTTAGGTGGCCTTGGGGGACTTG
CAGGTCTGAGTAGCTTGGGTTTGAATACTACCAACTTCTCTGAACTACAGAGTCAGATGCAGCGACAACTTTTGTCTAACCCTGAAATGA
TGGTCCAGATCATGGAAAATCCCTTTGTTCAGAGCATGCTCTCAAATCCTGACCTGATGAGACAGTTAATTATGGCCAATCCACAAATGC
AGCAGTTGATACAGAGAAATCCAGAAATTAGTCATATGTTGAATAATCCAGATATAATGAGACAAACGTTGGAACTTGCCAGGAATCCAG
CAATGATGCAGGAGATGATGAGGAACCAGGACCGAGCTTTGAGCAACCTAGAAAGCATCCCAGGGGGATATAATGCTTTAAGGCGCATGT
ACACAGATATTCAGGAACCAATGCTGAGTGCTGCACAAGAGCAGTTTGGTGGTAATCCATTTGCTTCCTTGGTGAGCAATACATCCTCTG
GTGAAGGTAGTCAACCTTCCCGTACAGAAAATAGAGATCCACTACCCAATCCATGGGCTCCACAGACTTCCCAGAGTTCATCAGCTTCCA
GCGGCACTGCCAGCACTGTGGGTGGCACTACTGGTAGTACTGCCAGTGGCACTTCTGGGCAGAGTACTACTGCGCCAAATTTGGTGCCTG
GAGTAGGAGAAATTTCACAAGCTATGGAACAAGAAGGTGCCACAGCAGCAGAGACAGAAGAACAAGGACATGGAGGTGACACATGGGACT
ACAAGAGTCACGTGATGACCAAATTCGCTGAGGAGGAGGATGTACGTCGTAGTTTTGAAAACACTGCTGCTGACTGGCCGGAAATGCAAA
CGTTGGCTGGTGCTTTTGATTCAGACCGGTGGGGCTTCCGGCCTCGCACGGTGGTTCTGCACGGAAAGTCAGGAATTGGGAAATCGGCTC
TAGCCAGAAGGATCGTGCTGTGCTGGGCGCAAGGTGGACTCTACCAGGGAATGTTCTCCTACGTCTTCTTCCTCCCCGTTAGAGAGATGC
AGCGGAAGAAGGAGAGCAGTGTCACAGAGTTCATCTCCAGGGAGTGGCCAGACTCCCAGGCTCCGGTGACGGAGATCATGTCCCGACCAG
AAAGGCTGTTGTTCATCATTGACGGTTTCGATGACCTGGGCTCTGTCCTCAACAATGACACAAAGCTCTGCAAAGACTGGGCTGAGAAGC
AGCCTCCGTTCACCCTCATACGCAGTCTGCTGAGGAAGGTCCTGCTCCCTGAGTCCTTCCTGATCGTCACCGTCAGAGACGTGGGCACAG
AGAAGCTCAAGTCAGAGGTCGTGTCTCCCCGTTACCTGTTAGTTAGAGGAATCTCCGGGGAACAAAGAATCCACTTGCTCCTTGAGCGCG
GGATTGGTGAGCATCAGAAGACACAAGGGTTGCGTGCGATCATGAACAACCGTGAGCTGCTCGACCAGTGCCAGGTGCCCGCCGTGGGCT
CTCTCATCTGCGTGGCCCTGCAGCTGCAGGACGTGGTGGGGGAGAGCGTCGCCCCCTTCAACCAAACGCTCACAGGCCTGCACGCCGCTT
TTGTGTTTCATCAGCTCACCCCTCGAGGCGTGGTCCGGCGCTGTCTCAATCTGGAGGAAAGAGTTGTCCTGAAGCGCTTCTGCCGTATGG
CTGTGGAGGGAGTGTGGAATAGGAAGTCAGTGTTTGACGGTGACGACCTCATGGTTCAAGGACTCGGGGAGTCTGAGCTCCGTGCTCTGT
TTCACATGAACATCCTTCTCCCAGACAGCCACTGTGAGGAGTACTACACCTTCTTCCACCTCAGTCTCCAGGACTTCTGTGCCGCCTTGT
ACTACGTGTTAGAGGGCCTGGAAATCGAGCCAGCTCTCTGCCCTCTGTACGTTGAGAAGACAAAGAGGTCCATGGAGCTTAAACAGGCAG
GCTTCCATATCCACTCGCTTTGGATGAAGCGTTTCTTGTTTGGCCTCGTGAGCGAAGACGTAAGGAGGCCACTGGAGGTCCTGCTGGGCT
GTCCCGTTCCCCTGGGGGTGAAGCAGAAGCTTCTGCACTGGGTCTCTCTGTTGGGTCAGCAGCCTAATGCCACCACCCCAGGAGACACCC
TGGACGCCTTCCACTGTCTTTTCGAGACTCAAGACAAAGAGTTTGTTCGCTTGGCATTAAACAGCTTCCAAGAAGTGTGGCTTCCGATTA
ACCAGAACCTGGACTTGATAGCATCTTCCTTCTGCCTCCAGCACTGTCCGTATTTGCGGAAAATTCGGGTGGATGTCAAAGGGATCTTCC
CAAGAGATGAGTCCGCTGAGGCATGTCCTGTGGTCCCTCTATGGATGCGGGATAAGACCCTCATTGAGGAGCAGTGGGAAGATTTCTGCT
CCATGCTTGGCACCCACCCACACCTGCGGCAGCTGGACCTGGGCAGCAGCATCCTGACAGAGCGGGCCATGAAGACCCTGTGTGCCAAGC
TGAGGCATCCCACCTGCAAGATACAGACCCTGATGTTTAGAAATGCACAGATTACCCCTGGTGTGCAGCACCTCTGGAGAATCGTCATGG
CCAACCGTAACCTAAGATCCCTCAACTTGGGAGGCACCCACCTGAAGGAAGAGGATGTAAGGATGGCGTGTGAAGCCTTAAAACACCCAA
AATGTTTGTTGGAGTCTTTGAGGCTGGATTGCTGTGGATTGACCCATGCCTGTTACCTGAAGATCTCCCAAATCCTTACGACCTCCCCCA
GCCTGAAATCTCTGAGCCTGGCAGGAAACAAGGTGACAGACCAGGGAGTAATGCCTCTCAGTGATGCCTTGAGAGTCTCCCAGTGCGCCC
TGCAGAAGCTGATACTGGAGGACTGTGGCATCACAGCCACGGGTTGCCAGAGTCTGGCCTCAGCCCTCGTCAGCAACCGGAGCTTGACAC
ACCTGTGCCTATCCAACAACAGCCTGGGGAACGAAGGTGTAAATCTACTGTGTCGATCCATGAGGCTTCCCCACTGTAGTCTGCAGAGGC
TGATGCTGAATCAGTGCCACCTGGACACGGCTGGCTGTGGTTTTCTTGCACTTGCGCTTATGGGTAACTCATGGCTGACGCACCTGAGCC
TTAGCATGAACCCTGTGGAAGACAATGGCGTGAAGCTTCTGTGCGAGGTCATGAGAGAACCATCTTGTCATCTCCAGGACCTGGAGTTGG
TAAAGTGTCATCTCACCGCCGCGTGCTGTGAGAGTCTGTCCTGTGTGATCTCGAGGAGCAGACACCTGAAGAGCCTGGATCTCACGGACA
ATGCCCTGGGTGACGGTGGGGTTGCTGCGCTGTGCGAGGGACTGAAGCAAAAGAACAGTGTTCTGGCGAGACTCGGGTTGAAGGCATGTG
GACTGACTTCTGATTGCTGTGAGGCACTCTCCTTGGCCCTTTCCTGCAACCGGCATCTGACCAGTCTAAACCTGGTGCAGAATAACTTCA
GTCCCAAAGGAATGATGAAGCTGTGTTCGGCCTTTGCCTGTCCCACGTCTAACTTACAGATAATTGGGCTGTGGAAATGGCAGTACCCTG
TGCAAATAAGGAAGCTGCTGGAGGAAGTGCAGCTACTCAAGCCCCGAGTCGTAATTGACGGTAGTTGGCATTCTTTTGATGAAGATGACC
GGTACTGGTGGAAAAACTGAAGATACGGAAACCTGCCCCACTCACACCCATCTGATGGAGGAACTTTAAACGCTGTTTTCTCAGAGCAAG
CTATGCACCTGGGAGTTCCTTCTCAAAGATGGAGAATGATTTCTGATTCTCACAAAGCCCTCAATGGTAGTGATTCTTCTGTGTTCACTC
TACGTTGGTTACTGGATTTGAAGGCTAGAGACCTTCAAGTCATAGGACTCAGTATCTGTGAAATGTCCGTCATATCTCAGAGCATATAGA

>96404_96404_6_UBQLN1-NLRP5_UBQLN1_chr9_86292642_ENST00000376395_NLRP5_chr19_56531741_ENST00000390649_length(amino acids)=1361AA_BP=368
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQFKEEISKRFKSHTDQLVLIFAGKILKDQDT
LSQHGIHDGLTVHLVIKTQNRPQDHSAQQTNTAGSNVTTSSTPNSNSTSGSATSNPFGLGGLGGLAGLSSLGLNTTNFSELQSQMQRQLL
SNPEMMVQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHMLNNPDIMRQTLELARNPAMMQEMMRNQDRALSNLESIPGGYN
ALRRMYTDIQEPMLSAAQEQFGGNPFASLVSNTSSGEGSQPSRTENRDPLPNPWAPQTSQSSSASSGTASTVGGTTGSTASGTSGQSTTA
PNLVPGVGEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFAEEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSG
IGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCK
DWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQ
VPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGES
ELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPL
EVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVD
VKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHL
WRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALR
VSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSW
LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARL
GLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVIDGSWHS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UBQLN1-NLRP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000257468-610178_428368.3333333333333562.0UBXN4
HgeneUBQLN1chr9:86292641chr19:56530707ENST00000376395-611178_428368.3333333333333590.0UBXN4
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000257468-610178_428368.3333333333333562.0UBXN4
HgeneUBQLN1chr9:86292641chr19:56531740ENST00000376395-611178_428368.3333333333333590.0UBXN4
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000257468-610178_428368.3333333333333562.0UBXN4
HgeneUBQLN1chr9:86292642chr19:56531741ENST00000376395-611178_428368.3333333333333590.0UBXN4


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for UBQLN1-NLRP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for UBQLN1-NLRP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource