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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UBQLN1-TLE1 (FusionGDB2 ID:96407)

Fusion Gene Summary for UBQLN1-TLE1

Fusion gene summary

Fusion gene information	Fusion gene name: UBQLN1-TLE1
	Fusion gene ID: 96407
		Hgene	Tgene
	Gene symbol	UBQLN1	TLE1
	Gene ID	29979	7088
	Gene name	ubiquilin 1	TLE family member 1, transcriptional corepressor
	Synonyms	DA41\|DSK2\|PLIC-1\|UBQN\|XDRP1	ESG\|ESG1\|GRG1
	Cytomap	9q21.32\|9q21.2-q21.3	9q21.32
	Type of gene	protein-coding	protein-coding
	Description	ubiquilin-1hPLIC-1protein linking IAP with cytoskeleton 1testicular tissue protein Li 219	transducin-like enhancer protein 1enhancer of split groucho-like protein 1transducin like enhancer of split 1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
	Modification date	20200327	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000257468, ENST00000376395,	ENST00000376472, ENST00000376463, ENST00000376484, ENST00000464999, ENST00000376499,
Fusion gene scores	* DoF score	14 X 12 X 8=1344	6 X 6 X 3=108
	# samples	16	6
	** MAII score	log2(16/1344*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UBQLN1 [Title/Abstract] AND TLE1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UBQLN1(86322414)-TLE1(84235472), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBQLN1	GO:0031396	regulation of protein ubiquitination	12634373
Hgene	UBQLN1	GO:0031398	positive regulation of protein ubiquitination	23307288
Hgene	UBQLN1	GO:0035973	aggrephagy	21143716
Tgene	TLE1	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	17680780
Tgene	TLE1	GO:0045892	negative regulation of transcription, DNA-templated	9751710

Fusion gene breakpoints across UBQLN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TLE1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	271N	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-

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Fusion Gene ORF analysis for UBQLN1-TLE1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000257468	ENST00000376472	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-
5CDS-5UTR	ENST00000376395	ENST00000376472	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-
5CDS-intron	ENST00000257468	ENST00000376463	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-
5CDS-intron	ENST00000257468	ENST00000376484	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-
5CDS-intron	ENST00000257468	ENST00000464999	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-
5CDS-intron	ENST00000376395	ENST00000376463	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-
5CDS-intron	ENST00000376395	ENST00000376484	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-
5CDS-intron	ENST00000376395	ENST00000464999	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-
In-frame	ENST00000257468	ENST00000376499	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-
In-frame	ENST00000376395	ENST00000376499	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000376395	UBQLN1	chr9	86322414	-	ENST00000376499	TLE1	chr9	84235472	-	2938	704	524	2422	632
ENST00000257468	UBQLN1	chr9	86322414	-	ENST00000376499	TLE1	chr9	84235472	-	2669	435	255	2153	632

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000376395	ENST00000376499	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-	0.003063664	0.9969363
ENST00000257468	ENST00000376499	UBQLN1	chr9	86322414	-	TLE1	chr9	84235472	-	0.003180296	0.99681973

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Fusion Genomic Features for UBQLN1-TLE1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBQLN1-TLE1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:86322414/chr9:84235472)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

225_228

198

771.0

Motif

Nuclear localization signal

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

200_268

198

771.0

Region

CcN domain

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

269_450

198

771.0

Region

SP domain

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

470_501

198

771.0

Repeat

Note=WD 1

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

528_558

198

771.0

Repeat

Note=WD 2

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

572_602

198

771.0

Repeat

Note=WD 3

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

614_644

198

771.0

Repeat

Note=WD 4

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

696_726

198

771.0

Repeat

Note=WD 5

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

737_767

198

771.0

Repeat

Note=WD 6

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000257468

182_210

562.0

Domain

STI1 1

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000257468

212_251

562.0

Domain

STI1 2

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000257468

37_111

562.0

Domain

Ubiquitin-like

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000257468

387_434

562.0

Domain

STI1 3

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000257468

438_470

562.0

Domain

STI1 4

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000257468

546_586

562.0

Domain

UBA

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000376395

182_210

590.0

Domain

STI1 1

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000376395

212_251

590.0

Domain

STI1 2

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000376395

37_111

590.0

Domain

Ubiquitin-like

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000376395

387_434

590.0

Domain

STI1 3

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000376395

438_470

590.0

Domain

STI1 4

Hgene

UBQLN1

chr9:86322414

chr9:84235472

ENST00000376395

546_586

590.0

Domain

UBA

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

132_199

198

771.0

Region

GP domain

Tgene

TLE1

chr9:86322414

chr9:84235472

ENST00000376499

1_131

198

771.0

Region

Q domain

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Fusion Gene Sequence for UBQLN1-TLE1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>96407_96407_1_UBQLN1-TLE1_UBQLN1_chr9_86322414_ENST00000257468_TLE1_chr9_84235472_ENST00000376499_length(transcript)=2669nt_BP=435nt
GCGGATGTCGGTGTGAGCGAGCGGCGCCTGAACACACGGCGGCTGCCGAGCGCCTGACCCGGGCCTGCGCCAGAGCCTGCACCGAGCTCC
GGGGCCCCACACCCGCTACGGTGGCCCTGCGCCCGTTGCTACTGAGGCGGCGTGCTCTGCATTCTTCGCTGTCCAGGCCTGCCGGCTCTG
GTGTCTGCTGGCTCCTCCTTGCTCGCCTGCTCCCTCCTGCTTGCCTGAGTCACCGCCGCCGCCGCCGCCACAGCCATGGCCGAGAGTGGT
GAAAGCGGCGGTCCTCCGGGCTCCCAGGATAGCGCCGCCGGAGCCGAAGGTGCTGGCGCCCCCGCGGCCGCTGCCTCCGCGGAGCCCAAA
ATCATGAAAGTCACCGTGAAGACCCCGAAGGAAAAGGAGGAATTCGCCGTGCCCGAGAATAGCTCCGTCCAGCAGAGTAATTCCCTCCTG
GTCCCAGACAGTCTAAGAGGCACAGATAAACGCAGAAATGGACCTGAATTTTCCAATGACATCAAGAAAAGGAAGGTGGATGATAAGGAC
TCCAGCCACTATGACAGTGATGGTGACAAAAGCGATGACAACTTAGTTGTGGATGTGTCTAATGAGGACCCTTCTTCTCCGCGAGCAAGC
CCTGCCCACTCGCCCCGGGAAAATGGAATCGACAAAAATCGCCTGCTAAAGAAGGATGCTTCTAGCAGTCCAGCTTCCACGGCCTCCTCG
GCAAGTTCCACTTCTTTGAAATCCAAAGAAATGAGCTTGCATGAAAAAGCCAGCACGCCTGTTCTGAAATCCAGCACACCAACGCCTCGG
AGCGACATGCCAACGCCGGGCACCAGCGCCACTCCAGGCCTCCGTCCAGGTCTCGGCAAGCCTCCAGCCATAGACCCCCTCGTTAACCAA
GCGGCAGCTGGCTTGAGGACACCCCTGGCAGTGCCCGGCCCATATCCTGCTCCTTTTGGGATGGTCCCCCACGCTGGCATGAACGGCGAG
CTGACCAGCCCAGGCGCTGCCTACGCCAGTTTACACAACATGTCGCCCCAGATGAGCGCCGCAGCCGCCGCGGCCGCCGTGGTGGCCTAC
GGGCGCTCCCCCATGGTGGGGTTTGATCCTCCCCCTCACATGAGAGTACCTACCATTCCTCCAAACCTGGCAGGAATCCCTGGGGGGAAA
CCTGCATACTCCTTCCACGTTACTGCAGACGGTCAGATGCAGCCTGTCCCTTTTCCCCCCGACGCCCTCATCGGACCCGGAATCCCCCGG
CATGCTCGCCAGATCAACACCCTCAACCACGGGGAGGTGGTGTGCGCTGTGACCATCAGCAACCCCACGAGACACGTGTACACAGGCGGG
AAGGGCTGCGTCAAGGTCTGGGACATCAGCCACCCTGGCAATAAGAGCCCTGTCTCCCAGCTCGACTGTCTGAACAGAGACAATTATATC
CGTTCCTGTAAATTGCTACCCGATGGCTGCACTCTCATAGTGGGAGGGGAAGCCAGTACTTTGTCCATTTGGGACCTGGCGGCTCCAACC
CCGCGCATCAAGGCGGAGCTGACGTCCTCGGCCCCCGCCTGCTACGCCCTGGCCATCAGCCCCGATTCCAAGGTCTGCTTCTCATGCTGC
AGCGACGGCAACATCGCTGTGTGGGATCTGCACAACCAGACACTAGTGAGGCAATTCCAGGGCCACACAGACGGAGCCAGCTGTATTGAC
ATTTCTAATGATGGCACCAAGCTCTGGACGGGTGGTTTGGACAACACAGTCAGGTCCTGGGACCTGCGCGAGGGGCGGCAGCTGCAGCAG
CACGACTTCACCTCCCAGATCTTCTCCCTGGGGTACTGCCCCACCGGGGAGTGGCTGGCAGTGGGCATGGAGAGCAGCAATGTGGAGGTG
CTGCACGTGAACAAGCCTGACAAGTACCAGCTGCACCTGCATGAGAGCTGCGTGCTGTCCCTGAAATTTGCTTACTGTGGTAAATGGTTT
GTGAGTACTGGAAAAGATAACCTCCTCAATGCTTGGCGGACCCCCTATGGAGCCAGCATATTCCAGTCCAAAGAGTCCTCGTCAGTGCTT
AGCTGTGACATCTCTGTGGATGATAAGTACATAGTCACTGGCTCGGGGGACAAGAAGGCTACAGTCTATGAAGTCATCTACTGAAAACAT
TATGTGGTTTAACGTTTATAGTTGAATTGGGCCAAAATGTTTCGAATTTATAGAAATAGAAAAGTTGTAACTTTAAAAGAGAAAAAAAAT
TACAAACACCTGTTTCCAAACCTTGACAGAAAACTACTTTGAGTCTACAAAGAGGAGGCGACAAGTCCATCAGCAGAAAGTCACCTGTCT
ACATAGACCAAATGGAGCACCAAGGCCAAGCGGACAGAGGGGCCATGGGTTGTAGGATTGAGGAACGGAATCTGCCGACTCACATGACAG
CCCATTCTTTCTTTCTGGGTGATCTGGGGATCACGCCTTGCCCAAGTGTGAGATTACCTTTCTGTTCCTTGCAGTTCACCTCACTTTCCG
TCCTTTGTAGAGCAGTGGTGTCTCCAATGAACTTGTTTCCTGGTTTTGCATCTTGTGAAATGTTTTTTTGTATTTTTGTTGAAGGTTAAA

>96407_96407_1_UBQLN1-TLE1_UBQLN1_chr9_86322414_ENST00000257468_TLE1_chr9_84235472_ENST00000376499_length(amino acids)=632AA_BP=57
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQSNSLLVPDSLRGTDKRRNGPEFSNDIKKRK
VDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASSTSLKSKEMSLHEKASTPVLKSS
TPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAA
AVVAYGRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRH
VYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKV
CFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMES
SNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEV

--------------------------------------------------------------
>96407_96407_2_UBQLN1-TLE1_UBQLN1_chr9_86322414_ENST00000376395_TLE1_chr9_84235472_ENST00000376499_length(transcript)=2938nt_BP=704nt
GGAAACTGCGATTTAGTTTTTGGTGAAAGGAGTGGAAAAAAACCATGAACTGACCTACCCCGCCCCATTTTGCTTTTAGTCCTTCACACT
GGCTTCGCCTGCACTTTGGGCAATGGAGCGGGAAAGGAAAAGGCACGCAGGCTGAGCTCAAAGTCGCGCCAGCCGGGGATGACTCGGCGA
CGCCGCCAGGCGCGTTACCCGGCGTGCTCCGCGCGGCGCCGGCGAAGGGACGTGGGGGAAGGGGCAGGGAGGAGGAAGCGGTGGCTGCTG
CGGATGTCGGTGTGAGCGAGCGGCGCCTGAACACACGGCGGCTGCCGAGCGCCTGACCCGGGCCTGCGCCAGAGCCTGCACCGAGCTCCG
GGGCCCCACACCCGCTACGGTGGCCCTGCGCCCGTTGCTACTGAGGCGGCGTGCTCTGCATTCTTCGCTGTCCAGGCCTGCCGGCTCTGG
TGTCTGCTGGCTCCTCCTTGCTCGCCTGCTCCCTCCTGCTTGCCTGAGTCACCGCCGCCGCCGCCGCCACAGCCATGGCCGAGAGTGGTG
AAAGCGGCGGTCCTCCGGGCTCCCAGGATAGCGCCGCCGGAGCCGAAGGTGCTGGCGCCCCCGCGGCCGCTGCCTCCGCGGAGCCCAAAA
TCATGAAAGTCACCGTGAAGACCCCGAAGGAAAAGGAGGAATTCGCCGTGCCCGAGAATAGCTCCGTCCAGCAGAGTAATTCCCTCCTGG
TCCCAGACAGTCTAAGAGGCACAGATAAACGCAGAAATGGACCTGAATTTTCCAATGACATCAAGAAAAGGAAGGTGGATGATAAGGACT
CCAGCCACTATGACAGTGATGGTGACAAAAGCGATGACAACTTAGTTGTGGATGTGTCTAATGAGGACCCTTCTTCTCCGCGAGCAAGCC
CTGCCCACTCGCCCCGGGAAAATGGAATCGACAAAAATCGCCTGCTAAAGAAGGATGCTTCTAGCAGTCCAGCTTCCACGGCCTCCTCGG
CAAGTTCCACTTCTTTGAAATCCAAAGAAATGAGCTTGCATGAAAAAGCCAGCACGCCTGTTCTGAAATCCAGCACACCAACGCCTCGGA
GCGACATGCCAACGCCGGGCACCAGCGCCACTCCAGGCCTCCGTCCAGGTCTCGGCAAGCCTCCAGCCATAGACCCCCTCGTTAACCAAG
CGGCAGCTGGCTTGAGGACACCCCTGGCAGTGCCCGGCCCATATCCTGCTCCTTTTGGGATGGTCCCCCACGCTGGCATGAACGGCGAGC
TGACCAGCCCAGGCGCTGCCTACGCCAGTTTACACAACATGTCGCCCCAGATGAGCGCCGCAGCCGCCGCGGCCGCCGTGGTGGCCTACG
GGCGCTCCCCCATGGTGGGGTTTGATCCTCCCCCTCACATGAGAGTACCTACCATTCCTCCAAACCTGGCAGGAATCCCTGGGGGGAAAC
CTGCATACTCCTTCCACGTTACTGCAGACGGTCAGATGCAGCCTGTCCCTTTTCCCCCCGACGCCCTCATCGGACCCGGAATCCCCCGGC
ATGCTCGCCAGATCAACACCCTCAACCACGGGGAGGTGGTGTGCGCTGTGACCATCAGCAACCCCACGAGACACGTGTACACAGGCGGGA
AGGGCTGCGTCAAGGTCTGGGACATCAGCCACCCTGGCAATAAGAGCCCTGTCTCCCAGCTCGACTGTCTGAACAGAGACAATTATATCC
GTTCCTGTAAATTGCTACCCGATGGCTGCACTCTCATAGTGGGAGGGGAAGCCAGTACTTTGTCCATTTGGGACCTGGCGGCTCCAACCC
CGCGCATCAAGGCGGAGCTGACGTCCTCGGCCCCCGCCTGCTACGCCCTGGCCATCAGCCCCGATTCCAAGGTCTGCTTCTCATGCTGCA
GCGACGGCAACATCGCTGTGTGGGATCTGCACAACCAGACACTAGTGAGGCAATTCCAGGGCCACACAGACGGAGCCAGCTGTATTGACA
TTTCTAATGATGGCACCAAGCTCTGGACGGGTGGTTTGGACAACACAGTCAGGTCCTGGGACCTGCGCGAGGGGCGGCAGCTGCAGCAGC
ACGACTTCACCTCCCAGATCTTCTCCCTGGGGTACTGCCCCACCGGGGAGTGGCTGGCAGTGGGCATGGAGAGCAGCAATGTGGAGGTGC
TGCACGTGAACAAGCCTGACAAGTACCAGCTGCACCTGCATGAGAGCTGCGTGCTGTCCCTGAAATTTGCTTACTGTGGTAAATGGTTTG
TGAGTACTGGAAAAGATAACCTCCTCAATGCTTGGCGGACCCCCTATGGAGCCAGCATATTCCAGTCCAAAGAGTCCTCGTCAGTGCTTA
GCTGTGACATCTCTGTGGATGATAAGTACATAGTCACTGGCTCGGGGGACAAGAAGGCTACAGTCTATGAAGTCATCTACTGAAAACATT
ATGTGGTTTAACGTTTATAGTTGAATTGGGCCAAAATGTTTCGAATTTATAGAAATAGAAAAGTTGTAACTTTAAAAGAGAAAAAAAATT
ACAAACACCTGTTTCCAAACCTTGACAGAAAACTACTTTGAGTCTACAAAGAGGAGGCGACAAGTCCATCAGCAGAAAGTCACCTGTCTA
CATAGACCAAATGGAGCACCAAGGCCAAGCGGACAGAGGGGCCATGGGTTGTAGGATTGAGGAACGGAATCTGCCGACTCACATGACAGC
CCATTCTTTCTTTCTGGGTGATCTGGGGATCACGCCTTGCCCAAGTGTGAGATTACCTTTCTGTTCCTTGCAGTTCACCTCACTTTCCGT
CCTTTGTAGAGCAGTGGTGTCTCCAATGAACTTGTTTCCTGGTTTTGCATCTTGTGAAATGTTTTTTTGTATTTTTGTTGAAGGTTAAAC

>96407_96407_2_UBQLN1-TLE1_UBQLN1_chr9_86322414_ENST00000376395_TLE1_chr9_84235472_ENST00000376499_length(amino acids)=632AA_BP=57
MAESGESGGPPGSQDSAAGAEGAGAPAAAASAEPKIMKVTVKTPKEKEEFAVPENSSVQQSNSLLVPDSLRGTDKRRNGPEFSNDIKKRK
VDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASSTSLKSKEMSLHEKASTPVLKSS
TPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAA
AVVAYGRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRH
VYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKV
CFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMES
SNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEV

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Fusion Gene PPI Analysis for UBQLN1-TLE1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	UBQLN1	chr9:86322414	chr9:84235472	ENST00000257468	-	1	10	178_428	60.0	562.0	UBXN4
Hgene	UBQLN1	chr9:86322414	chr9:84235472	ENST00000376395	-	1	11	178_428	60.0	590.0	UBXN4

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for UBQLN1-TLE1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for UBQLN1-TLE1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source