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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:UBQLN4-AHCYL1 (FusionGDB2 ID:96412)

Fusion Gene Summary for UBQLN4-AHCYL1

Fusion gene summary

Fusion gene information	Fusion gene name: UBQLN4-AHCYL1
	Fusion gene ID: 96412
		Hgene	Tgene
	Gene symbol	UBQLN4	AHCYL1
	Gene ID	56893	10768
	Gene name	ubiquilin 4	adenosylhomocysteinase like 1
	Synonyms	A1U\|A1Up\|C1orf6\|CIP75\|UBIN	DCAL\|IRBIT\|PPP1R78\|PRO0233\|XPVKONA
	Cytomap	1q22	1p13.3
	Type of gene	protein-coding	protein-coding
	Description	ubiquilin-4ataxin-1 interacting ubiquitin-like proteinataxin-1 ubiquitin-like interacting proteinataxin-1 ubiquitin-like-interacting protein A1Uconnexin43-interacting protein of 75 kDa	S-adenosylhomocysteine hydrolase-like protein 1DC-expressed AHCY-like moleculeIP(3)Rs binding protein released with IP(3)S-adenosyl homocysteine hydrolase homologS-adenosyl-L-homocysteine hydrolase 2adenosylhomocysteinase 2adoHcyase 2dendritic cell
	Modification date	20200313	20200313
	UniProtAcc	.	O43865
	Ensembl transtripts involved in fusion gene	ENST00000368309, ENST00000472638,	ENST00000475081, ENST00000359172, ENST00000393614, ENST00000369799,
Fusion gene scores	* DoF score	4 X 5 X 4=80	11 X 13 X 4=572
	# samples	5	12
	** MAII score	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/572*10)=-2.25298074116987 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UBQLN4 [Title/Abstract] AND AHCYL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UBQLN4(156011275)-AHCYL1(110551655), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBQLN4	GO:0006974	cellular response to DNA damage stimulus	30612738
Hgene	UBQLN4	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	27113755
Hgene	UBQLN4	GO:2000042	negative regulation of double-strand break repair via homologous recombination	30612738
Tgene	AHCYL1	GO:0006378	mRNA polyadenylation	19224921
Tgene	AHCYL1	GO:0031440	regulation of mRNA 3'-end processing	19224921
Tgene	AHCYL1	GO:0038166	angiotensin-activated signaling pathway	20584908
Tgene	AHCYL1	GO:0051592	response to calcium ion	18829453

Fusion gene breakpoints across UBQLN4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across AHCYL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-VP-A87K	UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+
ChimerDB4	PRAD	TCGA-VP-A87K	UBQLN4	chr1	156011276	-	AHCYL1	chr1	110551656	+

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Fusion Gene ORF analysis for UBQLN4-AHCYL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000368309	ENST00000475081	UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+
5CDS-3UTR	ENST00000368309	ENST00000475081	UBQLN4	chr1	156011276	-	AHCYL1	chr1	110551656	+
5CDS-5UTR	ENST00000368309	ENST00000359172	UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+
5CDS-5UTR	ENST00000368309	ENST00000359172	UBQLN4	chr1	156011276	-	AHCYL1	chr1	110551656	+
5CDS-5UTR	ENST00000368309	ENST00000393614	UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+
5CDS-5UTR	ENST00000368309	ENST00000393614	UBQLN4	chr1	156011276	-	AHCYL1	chr1	110551656	+
In-frame	ENST00000368309	ENST00000369799	UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+
In-frame	ENST00000368309	ENST00000369799	UBQLN4	chr1	156011276	-	AHCYL1	chr1	110551656	+
intron-3CDS	ENST00000472638	ENST00000369799	UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+
intron-3CDS	ENST00000472638	ENST00000369799	UBQLN4	chr1	156011276	-	AHCYL1	chr1	110551656	+
intron-3UTR	ENST00000472638	ENST00000475081	UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+
intron-3UTR	ENST00000472638	ENST00000475081	UBQLN4	chr1	156011276	-	AHCYL1	chr1	110551656	+
intron-5UTR	ENST00000472638	ENST00000359172	UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+
intron-5UTR	ENST00000472638	ENST00000359172	UBQLN4	chr1	156011276	-	AHCYL1	chr1	110551656	+
intron-5UTR	ENST00000472638	ENST00000393614	UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+
intron-5UTR	ENST00000472638	ENST00000393614	UBQLN4	chr1	156011276	-	AHCYL1	chr1	110551656	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000368309

UBQLN4

chr1

156011275

ENST00000369799

AHCYL1

chr1

110551655

5274

1746

3218

1041

ENST00000368309

UBQLN4

chr1

156011276

ENST00000369799

AHCYL1

chr1

110551656

5274

1746

3218

1041

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000368309	ENST00000369799	UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+	0.001137937	0.998862
ENST00000368309	ENST00000369799	UBQLN4	chr1	156011276	-	AHCYL1	chr1	110551656	+	0.001137937	0.998862

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Fusion Genomic Features for UBQLN4-AHCYL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+	6.97E-07	0.9999993
UBQLN4	chr1	156011275	-	AHCYL1	chr1	110551655	+	6.97E-07	0.9999993

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBQLN4-AHCYL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:156011275/chr1:110551655)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	AHCYL1 O43865
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate, competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. Promotes the formation of contact points between the endoplasmic reticulum (ER) and mitochondria, facilitating transfer of Ca(2+) from the ER to mitochondria (PubMed:27995898). Under normal cellular conditions, functions cooperatively with BCL2L10 to limit ITPR1-mediated Ca(2+) release but, under apoptotic stress conditions, dephosphorylated which promotes dissociation of both AHCYL1 and BCL2L10 from mitochondria-associated endoplasmic reticulum membranes, inhibits BCL2L10 interaction with ITPR1 and leads to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548). When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates from ITPR1 to interact with CFTR and SLC26A6, mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity). Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3(-) secretion (PubMed:16769890). Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity). Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908). Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453). May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921). Acts as a (dATP)-dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103). In vitro does not exhibit any S-adenosyl-L-homocysteine hydrolase activity (By similarity). {ECO:0000250\|UniProtKB:B5DFN2, ECO:0000250\|UniProtKB:Q80SW1, ECO:0000269\|PubMed:16769890, ECO:0000269\|PubMed:16793548, ECO:0000269\|PubMed:18829453, ECO:0000269\|PubMed:19224921, ECO:0000269\|PubMed:20584908, ECO:0000269\|PubMed:25237103, ECO:0000269\|PubMed:27995898}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBQLN4

chr1:156011275

chr1:110551655

ENST00000368309

13_87

551

602.0

Domain

Ubiquitin-like

Hgene

UBQLN4

chr1:156011275

chr1:110551655

ENST00000368309

192_229

551

602.0

Domain

STI1 1

Hgene

UBQLN4

chr1:156011275

chr1:110551655

ENST00000368309

230_261

551

602.0

Domain

STI1 2

Hgene

UBQLN4

chr1:156011275

chr1:110551655

ENST00000368309

393_440

551

602.0

Domain

STI1 3

Hgene

UBQLN4

chr1:156011275

chr1:110551655

ENST00000368309

444_476

551

602.0

Domain

STI1 4

Hgene

UBQLN4

chr1:156011276

chr1:110551656

ENST00000368309

13_87

551

602.0

Domain

Ubiquitin-like

Hgene

UBQLN4

chr1:156011276

chr1:110551656

ENST00000368309

192_229

551

602.0

Domain

STI1 1

Hgene

UBQLN4

chr1:156011276

chr1:110551656

ENST00000368309

230_261

551

602.0

Domain

STI1 2

Hgene

UBQLN4

chr1:156011276

chr1:110551656

ENST00000368309

393_440

551

602.0

Domain

STI1 3

Hgene

UBQLN4

chr1:156011276

chr1:110551656

ENST00000368309

444_476

551

602.0

Domain

STI1 4

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000359172

318_322

484.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000359172

397_399

484.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000369799

318_322

531.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000369799

397_399

531.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000393614

318_322

484.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000393614

397_399

484.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000359172

318_322

484.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000359172

397_399

484.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000369799

318_322

531.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000369799

397_399

531.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000393614

318_322

484.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000393614

397_399

484.0

Nucleotide binding

NAD

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000359172

281_448

484.0

Region

NAD binding

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000359172

520_530

484.0

Region

PDZ-binding

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000359172

65_92

484.0

Region

PEST

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000369799

281_448

531.0

Region

NAD binding

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000369799

520_530

531.0

Region

PDZ-binding

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000369799

65_92

531.0

Region

PEST

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000393614

281_448

484.0

Region

NAD binding

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000393614

520_530

484.0

Region

PDZ-binding

Tgene

AHCYL1

chr1:156011275

chr1:110551655

ENST00000393614

65_92

484.0

Region

PEST

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000359172

281_448

484.0

Region

NAD binding

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000359172

520_530

484.0

Region

PDZ-binding

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000359172

65_92

484.0

Region

PEST

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000369799

281_448

531.0

Region

NAD binding

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000369799

520_530

531.0

Region

PDZ-binding

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000369799

65_92

531.0

Region

PEST

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000393614

281_448

484.0

Region

NAD binding

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000393614

520_530

484.0

Region

PDZ-binding

Tgene

AHCYL1

chr1:156011276

chr1:110551656

ENST00000393614

65_92

484.0

Region

PEST

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBQLN4

chr1:156011275

chr1:110551655

ENST00000368309

553_598

551

602.0

Domain

UBA

Hgene

UBQLN4

chr1:156011276

chr1:110551656

ENST00000368309

553_598

551

602.0

Domain

UBA

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Fusion Gene Sequence for UBQLN4-AHCYL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>96412_96412_1_UBQLN4-AHCYL1_UBQLN4_chr1_156011275_ENST00000368309_AHCYL1_chr1_110551655_ENST00000369799_length(transcript)=5274nt_BP=1746nt
GTTGGAGGCGCAGAAGCCGAGCCGGGCCGGCCGGGCGGGCGGGGAGGAGGAGGAGCCGGGCGGGCTGGCGGGCGGCCGGGTGGCGGCGGC
GGCATGGCGGAGCCGAGCGGGGCCGAGACGAGGCCCCCCATTCGGGTCACCGTCAAGACCCCCAAGGACAAGGAGGAAATTGTGATCTGC
GATCGAGCCTCGGTCAAGGAGTTCAAAGAGGAAATCTCCCGGAGGTTTAAGGCTCAGCAGGATCAGCTGGTCCTGATCTTCGCAGGCAAG
ATCCTCAAGGATGGGGACACACTGAACCAGCACGGAATCAAGGACGGGCTCACTGTCCATCTGGTCATCAAGACCCCTCAGAAGGCTCAA
GATCCAGCTGCTGCCACTGCTTCTTCCCCCTCCACACCTGACCCTGCCTCAGCACCCTCCACCACGCCTGCTTCACCCGCCACCCCTGCC
CAGCCCTCCACCTCTGGCAGTGCCTCTTCAGATGCTGGCAGTGGAAGCCGGAGGAGCAGTGGTGGGGGGCCCTCTCCGGGGGCTGGGGAG
GGATCCCCCAGTGCTACTGCGTCCATACTCTCTGGCTTTGGGGGCATCCTGGGGCTGGGCAGCCTAGGCCTGGGCTCTGCCAACTTCATG
GAGCTGCAGCAGCAGATGCAGCGGCAGCTGATGTCCAATCCTGAGATGCTGTCACAGATCATGGAGAACCCCCTGGTCCAGGATATGATG
TCTAACCCTGATCTGATGCGTCACATGATTATGGCCAACCCCCAGATGCAGCAGTTGATGGAGCGGAACCCTGAGATCAGCCACATGCTC
AATAACCCTGAACTCATGAGGCAGACAATGGAGCTTGCTCGGAATCCAGCCATGATGCAAGAGATGATGCGGAACCAGGACCGGGCCCTG
AGCAACCTTGAGAGCATCCCTGGAGGGTATAATGCCCTCCGCCGCATGTACACGGACATCCAGGAGCCCATGTTCAGTGCTGCCCGGGAA
CAGTTTGGCAACAATCCCTTCTCTTCCCTGGCCGGGAACTCCGACAGCTCATCCTCCCAGCCTCTGCGGACTGAGAATCGAGAGCCCCTC
CCTAACCCCTGGAGCCCCTCGCCCCCCACCTCCCAGGCCCCCGGGTCCGGTGGGGAGGGCACCGGAGGATCGGGGACCAGCCAGGTGCAC
CCGACAGTCTCGAACCCCTTTGGGATCAATGCGGCTAGCCTGGGGTCAGGGATGTTCAATAGCCCAGAAATGCAAGCCCTCCTCCAGCAG
ATCTCTGAGAACCCCCAGCTGATGCAGAATGTGATCTCAGCACCCTACATGCGCAGCATGATGCAGACGCTTGCCCAGAACCCCGACTTT
GCTGCTCAGATGATGGTGAATGTGCCGCTCTTCGCGGGGAACCCCCAACTGCAGGAGCAGCTCCGCCTGCAGCTCCCAGTCTTCCTGCAG
CAGATGCAGAACCCAGAGTCACTCTCCATCCTTACCAATCCCCGAGCCATGCAGGCATTGCTGCAGATCCAGCAGGGACTACAGACCTTG
CAGACCGAGGCCCCTGGGCTGGTACCCAGCCTTGGCTCCTTTGGGATATCCCGGACCCCAGCACCCTCAGCAGGCAGCAACGCAGGGTCT
ACGCCCGAGGCCCCCACTTCCTCACCAGCCACGCCAGCCACATCTTCTCCAACAGGGGCTTCCAGCGCCCAGCAGCAACTCATGCAGCAG
ATGATCCAGCTTTTGGCTGGAAGTGGAAACTCACAGCAAATCCAGTTTGCTGATGACATGCAGGAGTTCACCAAATTCCCCACCAAAACT
GGCCGAAGATCTTTGTCTCGCTCGATCTCACAGTCCTCCACTGACAGCTACAGTTCAGCTGCATCCTACACAGATAGCTCTGATGATGAG
GTTTCTCCCCGAGAGAAGCAGCAAACCAACTCCAAGGGCAGCAGCAATTTCTGTGTGAAGAACATCAAGCAGGCAGAATTTGGACGCCGG
GAGATTGAGATTGCAGAGCAAGACATGTCTGCTCTGATTTCACTCAGGAAACGTGCTCAGGGGGAGAAGCCCTTGGCTGGTGCTAAAATA
GTGGGCTGTACACACATCACAGCCCAGACAGCGGTGTTGATTGAGACACTCTGTGCCCTGGGGGCTCAGTGCCGCTGGTCTGCTTGTAAC
ATCTACTCAACTCAGAATGAAGTAGCTGCAGCACTGGCTGAGGCTGGAGTTGCAGTGTTCGCTTGGAAGGGCGAGTCAGAAGATGACTTC
TGGTGGTGTATTGACCGCTGTGTGAACATGGATGGGTGGCAGGCCAACATGATCCTGGATGATGGGGGAGACTTAACCCACTGGGTTTAT
AAGAAGTATCCAAACGTGTTTAAGAAGATCCGAGGCATTGTGGAAGAGAGCGTGACTGGTGTTCACAGGCTGTATCAGCTCTCCAAAGCT
GGGAAGCTCTGTGTTCCGGCCATGAACGTCAATGATTCTGTTACCAAACAGAAGTTTGATAACTTGTACTGCTGCCGAGAATCCATTTTG
GATGGCCTGAAGAGGACCACAGATGTGATGTTTGGTGGGAAACAAGTGGTGGTGTGTGGCTATGGTGAGGTAGGCAAGGGCTGCTGTGCT
GCTCTCAAAGCTCTTGGAGCAATTGTCTACATTACCGAAATCGACCCCATCTGTGCTCTGCAGGCCTGCATGGATGGGTTCAGGGTGGTA
AAGCTAAATGAAGTCATCCGGCAAGTCGATGTCGTAATAACTTGCACAGGAAATAAGAATGTAGTGACACGGGAGCACTTGGATCGCATG
AAAAACAGTTGTATCGTATGCAATATGGGCCACTCCAACACAGAAATCGATGTGACCAGCCTCCGCACTCCGGAGCTGACGTGGGAGCGA
GTACGTTCTCAGGTGGACCATGTCATCTGGCCAGATGGCAAACGAGTTGTCCTCCTGGCAGAGGGTCGTCTACTCAATTTGAGCTGCTCC
ACAGTTCCCACCTTTGTTCTGTCCATCACAGCCACAACACAGGCTTTGGCACTGATAGAACTCTATAATGCACCCGAGGGGCGATACAAG
CAGGATGTGTACTTGCTTCCTAAGAAAATGGATGAATACGTTGCCAGCTTGCATCTGCCATCATTTGATGCCCACCTTACAGAGCTGACA
GATGACCAAGCAAAATATCTGGGACTCAACAAAAATGGGCCATTCAAACCTAATTATTACAGATACTAATGGACCATACTACCAAGGACC
AGTCCACCTGAACCACACACTCTAAAGAAATATTTTTTAAGATAACTTTTATTTTCTTCTTACTCCTTTCCTCTTGATTTTTTTCCTATA
ATTTCATTCTTGTTTTTTCATCTCATTATCCAAGTTCTGCAGACCACACAGGAACTTGCTTCATGGCTCTTTAGATGAAATAGAAGTTCA
GGGTTCCTCACTCTAGTCACTAAAGAAGGATTTTACTCTCCCAGCCCAGAAAGGTGATTCTTTCTTTACCATTTCTGGGGACTTTAGTCT
TAATTAGGTACCTTATTAACAGGAAATGCTAAGGTACCTTCTCTGTGGAACAATCTGCAATGTCTAAATCGCCTTAAAAGAGCCCATTTC
TTAGCTGCTGAAATCAGTGCTCTTTCACTTCTTCAGAGAAGCAGGGATGGTACCTACCCGGCAGGTAGGTTAGATGTGGGTGGTGCATGT
TAATTTCCCTTAGAAGTTCCAAGCCCTGTTTCCTGCGTAAAGGTGGTATGTCCAGTTCAGAGATGTGTATAATGAGCATGGCTTGTTAAG
ATCAGGAGGCCCACTTGGATTTATAGTATAGCCCTTCCTCCACTCCCACCAGACTTGCTCATTTTTCGAGTTTTTAACTAGACTACACTC
TATTGAGTTTAATTTTGTCCTCTAGGATTTATTTCTGTTGTCCAAAAAAAAAAAAAAAGAAAAGAAAAATTAAGGAGAATTTTTGGTGTT
AATGCTGAGGAATTGCTTGAGTGGTTAGTTGTTACCAATTTCTCTTTTGAACCTTTGGAGCTAAGGATGCTGAGTCTAGAGAAATGCTAG
TCTCAAGCCCTGTTAAGTCCCTCTGTTTCTAGCCCGTAGTTCATAGCATCAGTGAACTGGAGCCACAACAGCAAATTCTATCAGCTGTGT
ACCATACAGCTTGTGCTGAAGGCGAATTTCTTGAGCCATTACTCAGTATAAAGCACTGAGTTCTATCTTTAGGATTTATCTTTAAGAGCA
AATTTCTGGTCAGCTGTGCTTCTGCAACCTAAAATATTTAAAGGGAGGTAGGTGTGGGCAGGAGGAGGAATGATAAATTGGGCCAGGGCA
AGAAAAATCTAGCTTCATATAATTTGTCTGGGACTATACACCCTATATAATGTTAGTTTTACAGAAGTAATATGACTTTTGATTGCTACA
TACCACAAAGAGTTTATGAACTGAGATCATAAAGGGCAACTGATGTGTGAAGAAAGTAGTCAGTACATCCTGGCTCATGCTCTGAAAGAA
TATCCAGAGAGGCTCTCTCAAAGATCAGGGAGATGTATTCCCATGCCATGCACCCTGCTTCCCAGCATTTCTGCATGGTCAAGTGAGCTT
TATGCTCATGAGCTTTAAGTATATAATTATCCAGGATTTTAAATCCTCAACTTGTTCTAGCTTGTGATCCCTCAAAGTTGGGTCATACGT
TAGTGCTAGATACTAGAAATTTTCACTTTTCCACTGATCAGAGAGACAGACATTAAAAACAAAAATAGAAGAAAGGAAAGCTTTCACCCT
GCAGCTTCTTAGCAGGGAACAATTGTCTTGCCAAAACTTTTTTCCCTTTTCTCTCCCATTTTCTTTTACCCAATCCCTTCTTACTCCTTG
CCAGTGTGACCATGCTTTCTTCTCTGTAGATGTTAACAGTTAAGGCCTATTTTCCTCGGGCACTTAACCAACCAATCAGAACACCACATC
TGTTAGGGGAGGTAACCTGGCCAACAGTGTATCCATCACGTTAGCCCTGCTGGAGGGAAGGGACCCACATTCACCTGCCCTCTGACCTGC
CCCTTGATCCCATATCTATTACCGTGTCCATAGGAATAATAGGTAAGGGCTCTGTCTCTGTCAAGCCATGTAACAAAGGACACTGTTAAA
AAAAAAAAAAAGTCTGGCATCAGAGGGAGCATGTGGAGAGCAACTTGGGAAGAACAAGTTCATTTTGTATTGAATGATTTTTAATGAATG

>96412_96412_1_UBQLN4-AHCYL1_UBQLN4_chr1_156011275_ENST00000368309_AHCYL1_chr1_110551655_ENST00000369799_length(amino acids)=1041AA_BP=551
MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKAQD
PAAATASSPSTPDPASAPSTTPASPATPAQPSTSGSASSDAGSGSRRSSGGGPSPGAGEGSPSATASILSGFGGILGLGSLGLGSANFME
LQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALS
NLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWSPSPPTSQAPGSGGEGTGGSGTSQVHP
TVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQ
MQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGISRTPAPSAGSNAGSTPEAPTSSPATPATSSPTGASSAQQQLMQQM
IQLLAGSGNSQQIQFADDMQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRRE
IEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFW
WCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILD
GLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMK
NSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQ

--------------------------------------------------------------
>96412_96412_2_UBQLN4-AHCYL1_UBQLN4_chr1_156011276_ENST00000368309_AHCYL1_chr1_110551656_ENST00000369799_length(transcript)=5274nt_BP=1746nt
GTTGGAGGCGCAGAAGCCGAGCCGGGCCGGCCGGGCGGGCGGGGAGGAGGAGGAGCCGGGCGGGCTGGCGGGCGGCCGGGTGGCGGCGGC
GGCATGGCGGAGCCGAGCGGGGCCGAGACGAGGCCCCCCATTCGGGTCACCGTCAAGACCCCCAAGGACAAGGAGGAAATTGTGATCTGC
GATCGAGCCTCGGTCAAGGAGTTCAAAGAGGAAATCTCCCGGAGGTTTAAGGCTCAGCAGGATCAGCTGGTCCTGATCTTCGCAGGCAAG
ATCCTCAAGGATGGGGACACACTGAACCAGCACGGAATCAAGGACGGGCTCACTGTCCATCTGGTCATCAAGACCCCTCAGAAGGCTCAA
GATCCAGCTGCTGCCACTGCTTCTTCCCCCTCCACACCTGACCCTGCCTCAGCACCCTCCACCACGCCTGCTTCACCCGCCACCCCTGCC
CAGCCCTCCACCTCTGGCAGTGCCTCTTCAGATGCTGGCAGTGGAAGCCGGAGGAGCAGTGGTGGGGGGCCCTCTCCGGGGGCTGGGGAG
GGATCCCCCAGTGCTACTGCGTCCATACTCTCTGGCTTTGGGGGCATCCTGGGGCTGGGCAGCCTAGGCCTGGGCTCTGCCAACTTCATG
GAGCTGCAGCAGCAGATGCAGCGGCAGCTGATGTCCAATCCTGAGATGCTGTCACAGATCATGGAGAACCCCCTGGTCCAGGATATGATG
TCTAACCCTGATCTGATGCGTCACATGATTATGGCCAACCCCCAGATGCAGCAGTTGATGGAGCGGAACCCTGAGATCAGCCACATGCTC
AATAACCCTGAACTCATGAGGCAGACAATGGAGCTTGCTCGGAATCCAGCCATGATGCAAGAGATGATGCGGAACCAGGACCGGGCCCTG
AGCAACCTTGAGAGCATCCCTGGAGGGTATAATGCCCTCCGCCGCATGTACACGGACATCCAGGAGCCCATGTTCAGTGCTGCCCGGGAA
CAGTTTGGCAACAATCCCTTCTCTTCCCTGGCCGGGAACTCCGACAGCTCATCCTCCCAGCCTCTGCGGACTGAGAATCGAGAGCCCCTC
CCTAACCCCTGGAGCCCCTCGCCCCCCACCTCCCAGGCCCCCGGGTCCGGTGGGGAGGGCACCGGAGGATCGGGGACCAGCCAGGTGCAC
CCGACAGTCTCGAACCCCTTTGGGATCAATGCGGCTAGCCTGGGGTCAGGGATGTTCAATAGCCCAGAAATGCAAGCCCTCCTCCAGCAG
ATCTCTGAGAACCCCCAGCTGATGCAGAATGTGATCTCAGCACCCTACATGCGCAGCATGATGCAGACGCTTGCCCAGAACCCCGACTTT
GCTGCTCAGATGATGGTGAATGTGCCGCTCTTCGCGGGGAACCCCCAACTGCAGGAGCAGCTCCGCCTGCAGCTCCCAGTCTTCCTGCAG
CAGATGCAGAACCCAGAGTCACTCTCCATCCTTACCAATCCCCGAGCCATGCAGGCATTGCTGCAGATCCAGCAGGGACTACAGACCTTG
CAGACCGAGGCCCCTGGGCTGGTACCCAGCCTTGGCTCCTTTGGGATATCCCGGACCCCAGCACCCTCAGCAGGCAGCAACGCAGGGTCT
ACGCCCGAGGCCCCCACTTCCTCACCAGCCACGCCAGCCACATCTTCTCCAACAGGGGCTTCCAGCGCCCAGCAGCAACTCATGCAGCAG
ATGATCCAGCTTTTGGCTGGAAGTGGAAACTCACAGCAAATCCAGTTTGCTGATGACATGCAGGAGTTCACCAAATTCCCCACCAAAACT
GGCCGAAGATCTTTGTCTCGCTCGATCTCACAGTCCTCCACTGACAGCTACAGTTCAGCTGCATCCTACACAGATAGCTCTGATGATGAG
GTTTCTCCCCGAGAGAAGCAGCAAACCAACTCCAAGGGCAGCAGCAATTTCTGTGTGAAGAACATCAAGCAGGCAGAATTTGGACGCCGG
GAGATTGAGATTGCAGAGCAAGACATGTCTGCTCTGATTTCACTCAGGAAACGTGCTCAGGGGGAGAAGCCCTTGGCTGGTGCTAAAATA
GTGGGCTGTACACACATCACAGCCCAGACAGCGGTGTTGATTGAGACACTCTGTGCCCTGGGGGCTCAGTGCCGCTGGTCTGCTTGTAAC
ATCTACTCAACTCAGAATGAAGTAGCTGCAGCACTGGCTGAGGCTGGAGTTGCAGTGTTCGCTTGGAAGGGCGAGTCAGAAGATGACTTC
TGGTGGTGTATTGACCGCTGTGTGAACATGGATGGGTGGCAGGCCAACATGATCCTGGATGATGGGGGAGACTTAACCCACTGGGTTTAT
AAGAAGTATCCAAACGTGTTTAAGAAGATCCGAGGCATTGTGGAAGAGAGCGTGACTGGTGTTCACAGGCTGTATCAGCTCTCCAAAGCT
GGGAAGCTCTGTGTTCCGGCCATGAACGTCAATGATTCTGTTACCAAACAGAAGTTTGATAACTTGTACTGCTGCCGAGAATCCATTTTG
GATGGCCTGAAGAGGACCACAGATGTGATGTTTGGTGGGAAACAAGTGGTGGTGTGTGGCTATGGTGAGGTAGGCAAGGGCTGCTGTGCT
GCTCTCAAAGCTCTTGGAGCAATTGTCTACATTACCGAAATCGACCCCATCTGTGCTCTGCAGGCCTGCATGGATGGGTTCAGGGTGGTA
AAGCTAAATGAAGTCATCCGGCAAGTCGATGTCGTAATAACTTGCACAGGAAATAAGAATGTAGTGACACGGGAGCACTTGGATCGCATG
AAAAACAGTTGTATCGTATGCAATATGGGCCACTCCAACACAGAAATCGATGTGACCAGCCTCCGCACTCCGGAGCTGACGTGGGAGCGA
GTACGTTCTCAGGTGGACCATGTCATCTGGCCAGATGGCAAACGAGTTGTCCTCCTGGCAGAGGGTCGTCTACTCAATTTGAGCTGCTCC
ACAGTTCCCACCTTTGTTCTGTCCATCACAGCCACAACACAGGCTTTGGCACTGATAGAACTCTATAATGCACCCGAGGGGCGATACAAG
CAGGATGTGTACTTGCTTCCTAAGAAAATGGATGAATACGTTGCCAGCTTGCATCTGCCATCATTTGATGCCCACCTTACAGAGCTGACA
GATGACCAAGCAAAATATCTGGGACTCAACAAAAATGGGCCATTCAAACCTAATTATTACAGATACTAATGGACCATACTACCAAGGACC
AGTCCACCTGAACCACACACTCTAAAGAAATATTTTTTAAGATAACTTTTATTTTCTTCTTACTCCTTTCCTCTTGATTTTTTTCCTATA
ATTTCATTCTTGTTTTTTCATCTCATTATCCAAGTTCTGCAGACCACACAGGAACTTGCTTCATGGCTCTTTAGATGAAATAGAAGTTCA
GGGTTCCTCACTCTAGTCACTAAAGAAGGATTTTACTCTCCCAGCCCAGAAAGGTGATTCTTTCTTTACCATTTCTGGGGACTTTAGTCT
TAATTAGGTACCTTATTAACAGGAAATGCTAAGGTACCTTCTCTGTGGAACAATCTGCAATGTCTAAATCGCCTTAAAAGAGCCCATTTC
TTAGCTGCTGAAATCAGTGCTCTTTCACTTCTTCAGAGAAGCAGGGATGGTACCTACCCGGCAGGTAGGTTAGATGTGGGTGGTGCATGT
TAATTTCCCTTAGAAGTTCCAAGCCCTGTTTCCTGCGTAAAGGTGGTATGTCCAGTTCAGAGATGTGTATAATGAGCATGGCTTGTTAAG
ATCAGGAGGCCCACTTGGATTTATAGTATAGCCCTTCCTCCACTCCCACCAGACTTGCTCATTTTTCGAGTTTTTAACTAGACTACACTC
TATTGAGTTTAATTTTGTCCTCTAGGATTTATTTCTGTTGTCCAAAAAAAAAAAAAAAGAAAAGAAAAATTAAGGAGAATTTTTGGTGTT
AATGCTGAGGAATTGCTTGAGTGGTTAGTTGTTACCAATTTCTCTTTTGAACCTTTGGAGCTAAGGATGCTGAGTCTAGAGAAATGCTAG
TCTCAAGCCCTGTTAAGTCCCTCTGTTTCTAGCCCGTAGTTCATAGCATCAGTGAACTGGAGCCACAACAGCAAATTCTATCAGCTGTGT
ACCATACAGCTTGTGCTGAAGGCGAATTTCTTGAGCCATTACTCAGTATAAAGCACTGAGTTCTATCTTTAGGATTTATCTTTAAGAGCA
AATTTCTGGTCAGCTGTGCTTCTGCAACCTAAAATATTTAAAGGGAGGTAGGTGTGGGCAGGAGGAGGAATGATAAATTGGGCCAGGGCA
AGAAAAATCTAGCTTCATATAATTTGTCTGGGACTATACACCCTATATAATGTTAGTTTTACAGAAGTAATATGACTTTTGATTGCTACA
TACCACAAAGAGTTTATGAACTGAGATCATAAAGGGCAACTGATGTGTGAAGAAAGTAGTCAGTACATCCTGGCTCATGCTCTGAAAGAA
TATCCAGAGAGGCTCTCTCAAAGATCAGGGAGATGTATTCCCATGCCATGCACCCTGCTTCCCAGCATTTCTGCATGGTCAAGTGAGCTT
TATGCTCATGAGCTTTAAGTATATAATTATCCAGGATTTTAAATCCTCAACTTGTTCTAGCTTGTGATCCCTCAAAGTTGGGTCATACGT
TAGTGCTAGATACTAGAAATTTTCACTTTTCCACTGATCAGAGAGACAGACATTAAAAACAAAAATAGAAGAAAGGAAAGCTTTCACCCT
GCAGCTTCTTAGCAGGGAACAATTGTCTTGCCAAAACTTTTTTCCCTTTTCTCTCCCATTTTCTTTTACCCAATCCCTTCTTACTCCTTG
CCAGTGTGACCATGCTTTCTTCTCTGTAGATGTTAACAGTTAAGGCCTATTTTCCTCGGGCACTTAACCAACCAATCAGAACACCACATC
TGTTAGGGGAGGTAACCTGGCCAACAGTGTATCCATCACGTTAGCCCTGCTGGAGGGAAGGGACCCACATTCACCTGCCCTCTGACCTGC
CCCTTGATCCCATATCTATTACCGTGTCCATAGGAATAATAGGTAAGGGCTCTGTCTCTGTCAAGCCATGTAACAAAGGACACTGTTAAA
AAAAAAAAAAAGTCTGGCATCAGAGGGAGCATGTGGAGAGCAACTTGGGAAGAACAAGTTCATTTTGTATTGAATGATTTTTAATGAATG

>96412_96412_2_UBQLN4-AHCYL1_UBQLN4_chr1_156011276_ENST00000368309_AHCYL1_chr1_110551656_ENST00000369799_length(amino acids)=1041AA_BP=551
MAEPSGAETRPPIRVTVKTPKDKEEIVICDRASVKEFKEEISRRFKAQQDQLVLIFAGKILKDGDTLNQHGIKDGLTVHLVIKTPQKAQD
PAAATASSPSTPDPASAPSTTPASPATPAQPSTSGSASSDAGSGSRRSSGGGPSPGAGEGSPSATASILSGFGGILGLGSLGLGSANFME
LQQQMQRQLMSNPEMLSQIMENPLVQDMMSNPDLMRHMIMANPQMQQLMERNPEISHMLNNPELMRQTMELARNPAMMQEMMRNQDRALS
NLESIPGGYNALRRMYTDIQEPMFSAAREQFGNNPFSSLAGNSDSSSSQPLRTENREPLPNPWSPSPPTSQAPGSGGEGTGGSGTSQVHP
TVSNPFGINAASLGSGMFNSPEMQALLQQISENPQLMQNVISAPYMRSMMQTLAQNPDFAAQMMVNVPLFAGNPQLQEQLRLQLPVFLQQ
MQNPESLSILTNPRAMQALLQIQQGLQTLQTEAPGLVPSLGSFGISRTPAPSAGSNAGSTPEAPTSSPATPATSSPTGASSAQQQLMQQM
IQLLAGSGNSQQIQFADDMQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGSSNFCVKNIKQAEFGRRE
IEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAVLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFW
WCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILD
GLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMK
NSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UBQLN4-AHCYL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	AHCYL1	chr1:156011275	chr1:110551655	ENST00000359172		0	17	138_201	0	484.0	BCL2L10
Tgene	AHCYL1	chr1:156011275	chr1:110551655	ENST00000369799		0	17	138_201	40.0	531.0	BCL2L10
Tgene	AHCYL1	chr1:156011275	chr1:110551655	ENST00000393614		0	17	138_201	0	484.0	BCL2L10
Tgene	AHCYL1	chr1:156011276	chr1:110551656	ENST00000359172		0	17	138_201	0	484.0	BCL2L10
Tgene	AHCYL1	chr1:156011276	chr1:110551656	ENST00000369799		0	17	138_201	40.0	531.0	BCL2L10
Tgene	AHCYL1	chr1:156011276	chr1:110551656	ENST00000393614		0	17	138_201	0	484.0	BCL2L10

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for UBQLN4-AHCYL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for UBQLN4-AHCYL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source