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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UBR2-XPO5 (FusionGDB2 ID:96435)

Fusion Gene Summary for UBR2-XPO5

Fusion gene summary

Fusion gene information	Fusion gene name: UBR2-XPO5
	Fusion gene ID: 96435
		Hgene	Tgene
	Gene symbol	UBR2	XPO5
	Gene ID	23304	57510
	Gene name	ubiquitin protein ligase E3 component n-recognin 2	exportin 5
	Synonyms	C6orf133\|bA49A4.1\|dJ242G1.1\|dJ392M17.3	exp5
	Cytomap	6p21.1	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase UBR2RING-type E3 ubiquitin transferase UBR2ubiquitin-protein ligase E3-alpha-2ubiquitin-protein ligase E3-alpha-II	exportin-5ran-binding protein 21
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000372883, ENST00000372899, ENST00000372901, ENST00000372903,	ENST00000265351, ENST00000424378,
Fusion gene scores	* DoF score	9 X 9 X 6=486	3 X 4 X 3=36
	# samples	9	3
	** MAII score	log2(9/486*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UBR2 [Title/Abstract] AND XPO5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UBR2(42650849)-XPO5(43501744), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UBR2	GO:0071233	cellular response to leucine	20298436
Tgene	XPO5	GO:0006611	protein export from nucleus	11777942\|24209753
Tgene	XPO5	GO:0035281	pre-miRNA export from nucleus	15613540
Tgene	XPO5	GO:1900370	positive regulation of RNA interference	15613540

Fusion gene breakpoints across UBR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across XPO5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A59X-01A	UBR2	chr6	42650849	-	XPO5	chr6	43501744	-
ChimerDB4	PRAD	TCGA-KK-A59X-01A	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-

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Fusion Gene ORF analysis for UBR2-XPO5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000372883	ENST00000265351	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-
3UTR-intron	ENST00000372883	ENST00000424378	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-
5CDS-intron	ENST00000372899	ENST00000424378	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-
5CDS-intron	ENST00000372901	ENST00000424378	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-
In-frame	ENST00000372899	ENST00000265351	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-
In-frame	ENST00000372901	ENST00000265351	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-
intron-3CDS	ENST00000372903	ENST00000265351	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-
intron-intron	ENST00000372903	ENST00000424378	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000372899

UBR2

chr6

42650849

ENST00000265351

XPO5

chr6

43501744

7840

5033

258

6305

2015

ENST00000372901

UBR2

chr6

42650849

ENST00000265351

XPO5

chr6

43501744

7840

5033

258

6305

2015

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372899	ENST00000265351	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-	0.000523306	0.99947673
ENST00000372901	ENST00000265351	UBR2	chr6	42650849	+	XPO5	chr6	43501744	-	0.000504758	0.99949527

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Fusion Genomic Features for UBR2-XPO5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBR2-XPO5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:42650849/chr6:43501744)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372883

1019_1054

1054

662.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372899

1019_1054

1591

1756.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372901

1019_1054

1591

1756.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372883

1108_1214

1054

662.0

Zinc finger

Note=RING-type%3B atypical

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372883

97_168

1054

662.0

Zinc finger

UBR-type

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372899

1108_1214

1591

1756.0

Zinc finger

Note=RING-type%3B atypical

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372899

97_168

1591

1756.0

Zinc finger

UBR-type

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372901

1108_1214

1591

1756.0

Zinc finger

Note=RING-type%3B atypical

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372901

97_168

1591

1756.0

Zinc finger

UBR-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372903

1019_1054

440.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372903

1108_1214

440.0

Zinc finger

Note=RING-type%3B atypical

Hgene

UBR2

chr6:42650849

chr6:43501744

ENST00000372903

97_168

440.0

Zinc finger

UBR-type

Tgene

XPO5

chr6:42650849

chr6:43501744

ENST00000265351

641_642

780

1205.0

Region

Pre-miRNA binding

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Fusion Gene Sequence for UBR2-XPO5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>96435_96435_1_UBR2-XPO5_UBR2_chr6_42650849_ENST00000372899_XPO5_chr6_43501744_ENST00000265351_length(transcript)=7840nt_BP=5033nt
TTCTGTGTCCTTCCCTGGGTCAGGGACGAGCCAGTGACTTGACTCTTGGGCGCTAAGCTTGGGAGGGAGCGCAGGAGGCCGCTGTCCTTC
CTTTCCGGTTCACGTCACCCTTCTCTCCCTCTGTTGCTCCACCTGCAGCCACTTGGACGGCTCCGGGACTGATTGCCTGGGGCAGGGGTG
GCAGTCGAGGCCGCCGGGGCCGAGGTGAGGCTGCAGCTCTCCGGGCGGCGGTAGCGCTGGGGAGGAGGAGGAGAGAAGATGGCGTCGGAG
CTAGAGCCAGAGGTGCAGGCCATCGACCGGAGCTTGCTGGAATGTTCGGCCGAGGAGATTGCGGGGAAATGGCTGCAAGCAACTGACCTC
ACTAGAGAAGTGTACCAGCATTTAGCCCACTATGTACCCAAAATCTACTGCAGGGGTCCCAACCCTTTTCCACAGAAAGAAGACATGCTG
GCACAGCATGTTTTGTTGGGACCAATGGAATGGTACCTTTGTGGTGAAGATCCTGCATTTGGATTTCCAAAACTTGAGCAAGCAAACAAA
CCTTCTCATCTTTGTGGTCGTGTTTTTAAAGTAGGAGAGCCTACATATTCTTGCAGAGACTGTGCAGTTGATCCAACTTGTGTTTTGTGC
ATGGAGTGCTTTTTGGGAAGTATTCACAGAGATCATCGATATAGGATGACAACATCAGGAGGTGGAGGTTTCTGTGACTGTGGTGATACT
GAAGCCTGGAAAGAGGGTCCTTACTGTCAAAAACATGAACTTAACACCTCTGAAATTGAGGAAGAAGAGGATCCTCTTGTTCATTTATCA
GAAGATGTGATAGCAAGAACTTATAACATTTTTGCTATTACGTTTCGGTATGCAGTAGAAATATTAACCTGGGAAAAAGAAAGTGAATTG
CCAGCAGATTTAGAGATGGTAGAGAAGAGTGACACCTACTATTGCATGCTGTTTAATGATGAGGTTCACACCTATGAACAAGTTATTTAT
ACTCTTCAGAAAGCTGTTAACTGTACACAAAAAGAAGCTATTGGTTTTGCAACTACAGTAGATCGAGATGGGCGTAGGTCTGTTCGATAT
GGAGATTTTCAGTATTGTGAGCAAGCAAAATCAGTAATTGTGAGAAATACCAGTAGACAGACAAAGCCACTCAAAGTTCAAGTTATGCAT
TCGTCTATTGTCGCACATCAGAATTTTGGTTTGAAACTTTTGTCTTGGCTGGGAAGTATTATTGGATATTCAGATGGCCTTCGCCGGATT
TTATGTCAAGTTGGTTTACAAGAAGGGCCAGATGGTGAAAACTCTTCTCTAGTGGACAGACTGATGCTTAGTGATTCCAAATTATGGAAA
GGTGCTAGGAGTGTATATCATCAGTTGTTCATGAGCAGTCTGCTTATGGATTTGAAATACAAGAAACTATTTGCTGTTCGATTTGCAAAA
AATTACCAGCAGTTGCAGAGAGATTTTATGGAGGATGATCACGAGCGAGCAGTGTCGGTGACTGCTCTATCTGTCCAGTTCTTCACCGCA
CCTACTCTGGCTCGAATGCTCATCACAGAAGAAAACTTAATGAGCATTATCATTAAGACTTTTATGGATCATTTGAGACATCGAGATGCC
CAGGGCAGATTTCAGTTTGAACGATACACTGCTTTACAAGCCTTCAAATTTAGGAGAGTACAGAGCCTTATTTTAGATCTCAAGTATGTG
TTAATTAGCAAACCAACTGAATGGTCAGATGAGCTGAGGCAGAAGTTCCTAGAAGGGTTTGATGCCTTTTTGGAATTACTAAAATGTATG
CAGGGAATGGATCCAATTACACGTCAAGTAGGACAACATATTGAAATGGAACCAGAGTGGGAAGCAGCCTTCACACTACAAATGAAATTA
ACACATGTCATTTCAATGATGCAGGACTGGTGTGCTTCAGATGAAAAAGTGTTAATCGAAGCTTACAAGAAATGTCTCGCTGTACTGATG
CAGTGTCATGGTGGTTATACTGATGGTGAACAGCCAATCACACTAAGCATTTGTGGACATTCAGTGGAAACTATCAGATACTGTGTTTCC
CAAGAAAAAGTTAGCATTCACCTCCCAGTTTCTCGCTTACTTGCAGGTTTACATGTATTATTAAGCAAAAGTGAAGTGGCATATAAATTT
CCAGAGCTCCTACCTCTAAGTGAACTTAGCCCACCCATGTTGATAGAACACCCTCTTAGATGTCTTGTTCTGTGTGCCCAAGTACATGCC
GGAATGTGGAGAAGAAATGGGTTCTCTCTAGTAAACCAGATTTATTACTACCATAATGTGAAATGCAGACGTGAGATGTTTGACAAGGAT
GTAGTAATGCTTCAGACAGGTGTCTCCATGATGGATCCAAATCATTTCCTGATGATCATGCTCAGCCGCTTTGAACTTTATCAGATTTTC
AGTACTCCAGACTATGGAAAAAGATTTAGTTCTGAGATTACCCATAAGGATGTTGTTCAGCAGAACAATACTCTAATAGAAGAAATGCTA
TACCTCATTATAATGCTTGTTGGAGAGAGATTTAGTCCTGGAGTTGGACAGGTAAATGCTACAGATGAAATCAAGCGAGAGATTATCCAT
CAGTTGAGTATCAAGCCTATGGCTCATAGTGAATTGGTAAAGTCTTTACCTGAAGATGAGAACAAGGAGACTGGCATGGAGAGTGTAATC
GAAGCAGTTGCCCATTTCAAGAAACCTGGATTAACAGGACGAGGCATGTATGAACTGAAACCAGAATGTGCCAAAGAGTTCAACTTGTAT
TTCTATCACTTTTCAAGGGCAGAACAGTCCAAGGCAGAAGAAGCGCAACGGAAATTGAAAAGACAAAATAGAGAAGATACAGCACTCCCA
CCTCCGGTGTTGCCTCCATTCTGCCCTCTGTTTGCAAGCCTGGTTAACATTTTGCAGTCAGATGTCATGTTGTGCATCATGGGAACAATT
CTGCAATGGGCTGTGGAACATAATGGATATGCCTGGTCAGAGTCCATGCTGCAAAGGGTGTTACATTTAATTGGCATGGCACTACAAGAA
GAAAAACAACATTTAGAGAATGTCACGGAAGAGCATGTAGTAACATTTACCTTCACTCAGAAGATATCAAAACCTGGTGAAGCGCCAAAA
AATTCTCCTAGCATACTAGCTATGCTGGAAACACTACAAAATGCTCCCTACCTAGAAGTCCACAAAGACATGATTCGGTGGATATTGAAG
ACTTTTAATGCTGTTAAAAAGATGAGGGAGAGTTCACCTACCAGTCCCGTGGCAGAGACAGAAGGAACCATAATGGAAGAGAGTTCAAGG
GACAAAGACAAAGCTGAGAGGAAGAGAAAAGCAGAGATTGCCAGACTGCGCAGAGAAAAGATCATGGCTCAGATGTCTGAAATGCAGCGG
CATTTTATTGATGAAAACAAAGAACTCTTTCAGCAGACATTAGAACTGGATGCCTCAACCTCTGCTGTTCTTGATCATAGCCCTGTGGCT
TCAGATATGACACTTACAGCACTGGGCCCCGCACAAACTCAGGTTCCTGAACAAAGACAATTCGTTACATGTATATTGTGTCAAGAGGAG
CAAGAAGTTAAAGTGGAAAGCAGGGCAATGGTCTTGGCAGCATTTGTTCAGAGATCAACTGTATTATCAAAAAACAGAAGTAAATTTATT
CAAGATCCAGAAAAATATGATCCATTATTCATGCACCCTGATCTGTCTTGTGGAACACACACTAGTAGCTGTGGGCACATTATGCATGCC
CATTGTTGGCAAAGGTATTTTGATTCCGTTCAAGCTAAAGAACAGCGAAGGCAACAGAGATTACGCTTACATACGAGCTATGATGTAGAA
AACGGAGAATTCCTTTGCCCCCTTTGTGAATGCTTGAGTAATACTGTTATTCCTCTGCTGCTTCCTCCAAGAAATATTTTTAACAACAGG
TTAAATTTTTCAGACCAACCAAATCTGACTCAGTGGATTAGAACAATATCTCAGCAAATAAAAGCATTACAGTTTCTTAGGAAAGAAGAA
AGTACTCCTAATAATGCCTCTACAAAGAATTCAGAAAATGTGGATGAATTACAGCTCCCTGAAGGGTTCAGGCCTGATTTTCGTCCTAAG
ATCCCTTATTCTGAGAGCATAAAAGAAATGCTAACGACATTTGGAACTGCTACCTACAAGGTGGGACTAAAGGTTCATCCCAATGAAGAG
GATCCTCGTGTTCCCATAATGTGTTGGGGTAGCTGCGCGTACACCATCCAAAGCATAGAAAGAATTTTGAGTGATGAAGATAAACCATTG
TTTGGTCCTTTACCTTGCAGACTGGATGACTGTCTTAGGTCATTGACGAGATTTGCCGCAGCACACTGGACAGTGGCATCAGTTTCAGTG
GTGCAAGGACATTTTTGTAAACTTTTTGCATCACTGGTGCCTAATGACAGCCATGAGGAACTTCCATGCATATTAGATATTGACATGTTT
CATTTATTGGTGGGCTTGGTGCTTGCATTTCCTGCGTTGCAGTGTCAGGATTTTTCAGGGATCAGCCTTGGCACTGGAGACCTTCACATT
TTCCATCTGGTTACTATGGCACACATCATACAGATCTTACTTACCTCATGTACAGAAGAGAATGGCATGGATCAAGAAAATCCCCCTTGT
GAAGAAGAATCAGCAGTTCTTGCTTTGTATAAAACACTTCACCAGTATACGGGAAGTGCCTTGAAAGAAATACCATCCGGCTGGCATCTG
TGGAGGAGTGTCAGAGCTGGAATCATGCCTTTCCTGAAGTGTTCTGCTTTATTTTTTCATTACTTAAATGGAGTTCCTTCCCCACCCGAC
ATTCAAGTTCCTGGAACAAGCCATTTTGAACATTTATGTAGCTATCTTTCCCTACCAAACAACCTCATTTGCCTTTTTCAAGAAAATAGT
GAGATAATGAATTCACTGATTGAAAGTTGGTGCCGTAACAGTGAAGTTAAAAGATATCTAGAAGGTGAAAGAGATGCTATAAGAACCCAC
AATACATTATATGCACCAGAAATGCTAGCCAAAATGGCAGAGCCTTTCACCAAGGCTCTGGATATGCTTGACGCGGAAAAATCTGCTATA
TTAGGATTACCTCAACCTCTCTTGGAACTCAATGACTCTCCTGTCTTCAAAACCGTCTTGGAAAGAATGCAGCGTTTCTTCTCTACCCTC
TATGAAAACTGTTTTCATATCCTAGGGAAGGCAGGCCCTTCCATGCAGCAAGACTTCTATACTGTGGAGGACCTTGCTACCCAGCTTCTC
AGCTCAGCCTTTGTCAACTTGAACAATATTCCTGACTACCGACTCAGACCCATGCTTCGTGTCTTTGTAAAGCCTCTGGTGCTCTTCTGT
CCCCCAGAGCACTATGAAGCCCTGGTATCCCCCATCCTCGGACCTCTTTTCACCTACCTCCATATGAGGCTTTCTCAGAAATGGCAAGTT
ATCAACCAAAGGAGCCTGCTGTGTGGAGAAGATGAGGCTGCAGATGAAAACCCAGAGTCTCAAGAGATGCTGGAGGAGCAACTGGTGAGG
ATGTTAACCCGAGAAGTCATGGACCTAATCACGGTTTGCTGTGTTTCAAAGAAGGGTGCTGACCACAGTAGTGCTCCCCCAGCAGATGGA
GACGATGAAGAAATGATGGCCACAGAGGTCACCCCCTCAGCTATGGCAGAGCTTACAGACCTGGGCAAATGTCTGATGAAGCATGAGGAT
GTTTGTACAGCGCTATTAATTACAGCCTTCAATTCCCTGGCCTGGAAAGATACTCTGTCCTGCCAGAGGACAACCTCACAGCTCTGCTGG
CCTCTCCTCAAACAAGTGCTGTCAGGGACACTGCTCGCAGATGCAGTTACGTGGCTTTTCACCAGTGTGCTGAAAGGCTTACAGATGCAC
GGGCAGCACGACGGGTGCATGGCTTCCCTGGTCCATCTGGCCTTCCAGATATACGAGGCACTGCGCCCCAGGTACCTGGAGATAAGAGCT
GTAATGGAGCAAATCCCTGAAATACAGAAGGACTCACTGGACCAGTTTGACTGCAAGCTTTTAAACCCCTCCCTGCAGAAAGTGGCTGAC
AAGCGCCGAAAGGACCAATTCAAACGCCTCATTGCTGGTTGCATTGGGAAACCCTTGGGAGAGCAGTTCCGAAAAGAAGTTCACATTAAG
AATCTTCCCTCACTTTTCAAAAAAACAAAGCCAATGCTGGAGACGGAGGTGCTGGACAATGATGGGGGTGGCCTGGCCACCATCTTTGAA
CCCTGAATCAAGCTTTTGGGCATCCTTCCTCGGCCTTTCTTGTCATCTCTTCTTTCCCTTTGTAGCCGATCTCTAGGCCCTTCTTGCACT
GCCACCTCACTTTCCACCACTGTCAGCCTGGAAAGAGATCCAGGTCTGGAGCTGGAGAGAACAGGCCCTGTGCAGGACCAGAAGTAATTA
TACTAAAGTATCAAGAAAGGGAGTTAGGGCTTAAACTATTCTGTCTAGATGTCCCAGATAGTTCCCATTCTACTTGGAGATTTGGCTTTT
CCAAGAAAAGCTAGAGCAGAGCAGCCCTTCTCCCACAAGCCCTCCCACCCCCGTGCAGCCACATACCTGTACAGAATGGTAACTAAGGGT
GCTGTGCCCAACCCTGCGACTAGCAAGGCTCGCAGCAAGAGCACAGCCCTCAACTACTTGTGCCAGAGTTTCTCTTGGACCACTCCAACT
CCCACTGAGCCCTTTTGCTGCTGGGCTGGCAGGAAACTTTCCCCACTCCCTAAGGGGCATGTCTGGGTTAGGTGCTAAGTGCTGAAGAGA
ACTTGGTCAGTTCTCTCAACTTTGCTTTGGGCAAGAATCTGGTCACCTGATGGGATCCATGGTACAGGCTACTGCTAAACTTGGCACAGT
ATCAAGTATAGTACCTCCAAGGACCAGGGCTGGGAAGTCTTTAGTGCTAACATCCCCTTTAGAGTTCACACATCTTGCCCTTCCATGAAT
GACCCCTCAGTCTGGCCTCCCCAGCCTCAAGGTCCACTCAGGCACAAGAGCCACAGTACCCTAGATAGTGTCACATGACACCGTTGTCAT
CCAAGGATAATACAGACCAACTAGGCTACATCTGTGATGAGCAGCTAGCAAAGCCGCTGGTCTTCTCCTAGGACTAAGTCCAGGTGCCTT
CCACAATCTCATGGTCTTTCAGGTCCCTGGTTACTTTTCTCAAAGGCCATTTCCAAAAGAATACATGCCTTCACATCACAACCTGTACTG
TGAGTCCATTCTAGAGGTCACTGAAAGGCCCTGTAAAGAGAGGACATGGATACGGGACCTGGCCCTGAGGTTATTACTGGCCGTAAGGCA
GAGTTAATCCATACAGAAACCAGTGTGTCCATGTGCTCTGCACAAAAACAGACCTGTTGTCCATCCAGTCCACTGACAAGAGGGTTTCCC
CGAGAGCCGAAGTGGACTGAAGCTACAGTTTTTAGCTGGTGCGGGCCACAGGCAGGGTCAGATTGAGAAGAAGCAAAGCTGGGGAAGCAG
AAGTTGGGAGTCTTGTGTTGCTCCCTCTTCCTGTGTGGTGCTCTGGGTTTCTGTGGATCGTGAAGGCGATCTCAAGAGTGTTTCCCTCCA
AACCTGATAGCTGCCTATTCCTGTCTGGTTGGGGCTGTGGAGGATGTAGTTGTATTTATTGCATTGTAATATTTTTAACATCCTGTGACT
TCATGCTAGAAATTTTCTATTGTTTATAGAAACTTTTTGTAGAAACATTAACTCTAAAGCACATCTGCATGTCAGTAAAAATCTCAGTTT

>96435_96435_1_UBR2-XPO5_UBR2_chr6_42650849_ENST00000372899_XPO5_chr6_43501744_ENST00000265351_length(amino acids)=2015AA_BP=1591
MASELEPEVQAIDRSLLECSAEEIAGKWLQATDLTREVYQHLAHYVPKIYCRGPNPFPQKEDMLAQHVLLGPMEWYLCGEDPAFGFPKLE
QANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPL
VHLSEDVIARTYNIFAITFRYAVEILTWEKESELPADLEMVEKSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRR
SVRYGDFQYCEQAKSVIVRNTSRQTKPLKVQVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLSDS
KLWKGARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYQQLQRDFMEDDHERAVSVTALSVQFFTAPTLARMLITEENLMSIIIKTFMDHLR
HRDAQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKPTEWSDELRQKFLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTL
QMKLTHVISMMQDWCASDEKVLIEAYKKCLAVLMQCHGGYTDGEQPITLSICGHSVETIRYCVSQEKVSIHLPVSRLLAGLHVLLSKSEV
AYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDVVMLQTGVSMMDPNHFLMIMLSRFEL
YQIFSTPDYGKRFSSEITHKDVVQQNNTLIEEMLYLIIMLVGERFSPGVGQVNATDEIKREIIHQLSIKPMAHSELVKSLPEDENKETGM
ESVIEAVAHFKKPGLTGRGMYELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRQNREDTALPPPVLPPFCPLFASLVNILQSDVMLCI
MGTILQWAVEHNGYAWSESMLQRVLHLIGMALQEEKQHLENVTEEHVVTFTFTQKISKPGEAPKNSPSILAMLETLQNAPYLEVHKDMIR
WILKTFNAVKKMRESSPTSPVAETEGTIMEESSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDASTSAVLDH
SPVASDMTLTALGPAQTQVPEQRQFVTCILCQEEQEVKVESRAMVLAAFVQRSTVLSKNRSKFIQDPEKYDPLFMHPDLSCGTHTSSCGH
IMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRNIFNNRLNFSDQPNLTQWIRTISQQIKALQFL
RKEESTPNNASTKNSENVDELQLPEGFRPDFRPKIPYSESIKEMLTTFGTATYKVGLKVHPNEEDPRVPIMCWGSCAYTIQSIERILSDE
DKPLFGPLPCRLDDCLRSLTRFAAAHWTVASVSVVQGHFCKLFASLVPNDSHEELPCILDIDMFHLLVGLVLAFPALQCQDFSGISLGTG
DLHIFHLVTMAHIIQILLTSCTEENGMDQENPPCEEESAVLALYKTLHQYTGSALKEIPSGWHLWRSVRAGIMPFLKCSALFFHYLNGVP
SPPDIQVPGTSHFEHLCSYLSLPNNLICLFQENSEIMNSLIESWCRNSEVKRYLEGERDAIRTHNTLYAPEMLAKMAEPFTKALDMLDAE
KSAILGLPQPLLELNDSPVFKTVLERMQRFFSTLYENCFHILGKAGPSMQQDFYTVEDLATQLLSSAFVNLNNIPDYRLRPMLRVFVKPL
VLFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQLVRMLTREVMDLITVCCVSKKGADHSSAP
PADGDDEEMMATEVTPSAMAELTDLGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKG
LQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQKVADKRRKDQFKRLIAGCIGKPLGEQFRKE

--------------------------------------------------------------
>96435_96435_2_UBR2-XPO5_UBR2_chr6_42650849_ENST00000372901_XPO5_chr6_43501744_ENST00000265351_length(transcript)=7840nt_BP=5033nt
TTCTGTGTCCTTCCCTGGGTCAGGGACGAGCCAGTGACTTGACTCTTGGGCGCTAAGCTTGGGAGGGAGCGCAGGAGGCCGCTGTCCTTC
CTTTCCGGTTCACGTCACCCTTCTCTCCCTCTGTTGCTCCACCTGCAGCCACTTGGACGGCTCCGGGACTGATTGCCTGGGGCAGGGGTG
GCAGTCGAGGCCGCCGGGGCCGAGGTGAGGCTGCAGCTCTCCGGGCGGCGGTAGCGCTGGGGAGGAGGAGGAGAGAAGATGGCGTCGGAG
CTAGAGCCAGAGGTGCAGGCCATCGACCGGAGCTTGCTGGAATGTTCGGCCGAGGAGATTGCGGGGAAATGGCTGCAAGCAACTGACCTC
ACTAGAGAAGTGTACCAGCATTTAGCCCACTATGTACCCAAAATCTACTGCAGGGGTCCCAACCCTTTTCCACAGAAAGAAGACATGCTG
GCACAGCATGTTTTGTTGGGACCAATGGAATGGTACCTTTGTGGTGAAGATCCTGCATTTGGATTTCCAAAACTTGAGCAAGCAAACAAA
CCTTCTCATCTTTGTGGTCGTGTTTTTAAAGTAGGAGAGCCTACATATTCTTGCAGAGACTGTGCAGTTGATCCAACTTGTGTTTTGTGC
ATGGAGTGCTTTTTGGGAAGTATTCACAGAGATCATCGATATAGGATGACAACATCAGGAGGTGGAGGTTTCTGTGACTGTGGTGATACT
GAAGCCTGGAAAGAGGGTCCTTACTGTCAAAAACATGAACTTAACACCTCTGAAATTGAGGAAGAAGAGGATCCTCTTGTTCATTTATCA
GAAGATGTGATAGCAAGAACTTATAACATTTTTGCTATTACGTTTCGGTATGCAGTAGAAATATTAACCTGGGAAAAAGAAAGTGAATTG
CCAGCAGATTTAGAGATGGTAGAGAAGAGTGACACCTACTATTGCATGCTGTTTAATGATGAGGTTCACACCTATGAACAAGTTATTTAT
ACTCTTCAGAAAGCTGTTAACTGTACACAAAAAGAAGCTATTGGTTTTGCAACTACAGTAGATCGAGATGGGCGTAGGTCTGTTCGATAT
GGAGATTTTCAGTATTGTGAGCAAGCAAAATCAGTAATTGTGAGAAATACCAGTAGACAGACAAAGCCACTCAAAGTTCAAGTTATGCAT
TCGTCTATTGTCGCACATCAGAATTTTGGTTTGAAACTTTTGTCTTGGCTGGGAAGTATTATTGGATATTCAGATGGCCTTCGCCGGATT
TTATGTCAAGTTGGTTTACAAGAAGGGCCAGATGGTGAAAACTCTTCTCTAGTGGACAGACTGATGCTTAGTGATTCCAAATTATGGAAA
GGTGCTAGGAGTGTATATCATCAGTTGTTCATGAGCAGTCTGCTTATGGATTTGAAATACAAGAAACTATTTGCTGTTCGATTTGCAAAA
AACTATGAGCGTTTGCAGAGTGATTATGTGACAGATGACCACGACAGAGAGTTTTCAGTCGCAGACCTCTCGGTTCAGATATTCACGGTT
CCTTCACTTGCTCGAATGCTCATCACAGAAGAAAACTTAATGAGCATTATCATTAAGACTTTTATGGATCATTTGAGACATCGAGATGCC
CAGGGCAGATTTCAGTTTGAACGATACACTGCTTTACAAGCCTTCAAATTTAGGAGAGTACAGAGCCTTATTTTAGATCTCAAGTATGTG
TTAATTAGCAAACCAACTGAATGGTCAGATGAGCTGAGGCAGAAGTTCCTAGAAGGGTTTGATGCCTTTTTGGAATTACTAAAATGTATG
CAGGGAATGGATCCAATTACACGTCAAGTAGGACAACATATTGAAATGGAACCAGAGTGGGAAGCAGCCTTCACACTACAAATGAAATTA
ACACATGTCATTTCAATGATGCAGGACTGGTGTGCTTCAGATGAAAAAGTGTTAATCGAAGCTTACAAGAAATGTCTCGCTGTACTGATG
CAGTGTCATGGTGGTTATACTGATGGTGAACAGCCAATCACACTAAGCATTTGTGGACATTCAGTGGAAACTATCAGATACTGTGTTTCC
CAAGAAAAAGTTAGCATTCACCTCCCAGTTTCTCGCTTACTTGCAGGTTTACATGTATTATTAAGCAAAAGTGAAGTGGCATATAAATTT
CCAGAGCTCCTACCTCTAAGTGAACTTAGCCCACCCATGTTGATAGAACACCCTCTTAGATGTCTTGTTCTGTGTGCCCAAGTACATGCC
GGAATGTGGAGAAGAAATGGGTTCTCTCTAGTAAACCAGATTTATTACTACCATAATGTGAAATGCAGACGTGAGATGTTTGACAAGGAT
GTAGTAATGCTTCAGACAGGTGTCTCCATGATGGATCCAAATCATTTCCTGATGATCATGCTCAGCCGCTTTGAACTTTATCAGATTTTC
AGTACTCCAGACTATGGAAAAAGATTTAGTTCTGAGATTACCCATAAGGATGTTGTTCAGCAGAACAATACTCTAATAGAAGAAATGCTA
TACCTCATTATAATGCTTGTTGGAGAGAGATTTAGTCCTGGAGTTGGACAGGTAAATGCTACAGATGAAATCAAGCGAGAGATTATCCAT
CAGTTGAGTATCAAGCCTATGGCTCATAGTGAATTGGTAAAGTCTTTACCTGAAGATGAGAACAAGGAGACTGGCATGGAGAGTGTAATC
GAAGCAGTTGCCCATTTCAAGAAACCTGGATTAACAGGACGAGGCATGTATGAACTGAAACCAGAATGTGCCAAAGAGTTCAACTTGTAT
TTCTATCACTTTTCAAGGGCAGAACAGTCCAAGGCAGAAGAAGCGCAACGGAAATTGAAAAGACAAAATAGAGAAGATACAGCACTCCCA
CCTCCGGTGTTGCCTCCATTCTGCCCTCTGTTTGCAAGCCTGGTTAACATTTTGCAGTCAGATGTCATGTTGTGCATCATGGGAACAATT
CTGCAATGGGCTGTGGAACATAATGGATATGCCTGGTCAGAGTCCATGCTGCAAAGGGTGTTACATTTAATTGGCATGGCACTACAAGAA
GAAAAACAACATTTAGAGAATGTCACGGAAGAGCATGTAGTAACATTTACCTTCACTCAGAAGATATCAAAACCTGGTGAAGCGCCAAAA
AATTCTCCTAGCATACTAGCTATGCTGGAAACACTACAAAATGCTCCCTACCTAGAAGTCCACAAAGACATGATTCGGTGGATATTGAAG
ACTTTTAATGCTGTTAAAAAGATGAGGGAGAGTTCACCTACCAGTCCCGTGGCAGAGACAGAAGGAACCATAATGGAAGAGAGTTCAAGG
GACAAAGACAAAGCTGAGAGGAAGAGAAAAGCAGAGATTGCCAGACTGCGCAGAGAAAAGATCATGGCTCAGATGTCTGAAATGCAGCGG
CATTTTATTGATGAAAACAAAGAACTCTTTCAGCAGACATTAGAACTGGATGCCTCAACCTCTGCTGTTCTTGATCATAGCCCTGTGGCT
TCAGATATGACACTTACAGCACTGGGCCCCGCACAAACTCAGGTTCCTGAACAAAGACAATTCGTTACATGTATATTGTGTCAAGAGGAG
CAAGAAGTTAAAGTGGAAAGCAGGGCAATGGTCTTGGCAGCATTTGTTCAGAGATCAACTGTATTATCAAAAAACAGAAGTAAATTTATT
CAAGATCCAGAAAAATATGATCCATTATTCATGCACCCTGATCTGTCTTGTGGAACACACACTAGTAGCTGTGGGCACATTATGCATGCC
CATTGTTGGCAAAGGTATTTTGATTCCGTTCAAGCTAAAGAACAGCGAAGGCAACAGAGATTACGCTTACATACGAGCTATGATGTAGAA
AACGGAGAATTCCTTTGCCCCCTTTGTGAATGCTTGAGTAATACTGTTATTCCTCTGCTGCTTCCTCCAAGAAATATTTTTAACAACAGG
TTAAATTTTTCAGACCAACCAAATCTGACTCAGTGGATTAGAACAATATCTCAGCAAATAAAAGCATTACAGTTTCTTAGGAAAGAAGAA
AGTACTCCTAATAATGCCTCTACAAAGAATTCAGAAAATGTGGATGAATTACAGCTCCCTGAAGGGTTCAGGCCTGATTTTCGTCCTAAG
ATCCCTTATTCTGAGAGCATAAAAGAAATGCTAACGACATTTGGAACTGCTACCTACAAGGTGGGACTAAAGGTTCATCCCAATGAAGAG
GATCCTCGTGTTCCCATAATGTGTTGGGGTAGCTGCGCGTACACCATCCAAAGCATAGAAAGAATTTTGAGTGATGAAGATAAACCATTG
TTTGGTCCTTTACCTTGCAGACTGGATGACTGTCTTAGGTCATTGACGAGATTTGCCGCAGCACACTGGACAGTGGCATCAGTTTCAGTG
GTGCAAGGACATTTTTGTAAACTTTTTGCATCACTGGTGCCTAATGACAGCCATGAGGAACTTCCATGCATATTAGATATTGACATGTTT
CATTTATTGGTGGGCTTGGTGCTTGCATTTCCTGCGTTGCAGTGTCAGGATTTTTCAGGGATCAGCCTTGGCACTGGAGACCTTCACATT
TTCCATCTGGTTACTATGGCACACATCATACAGATCTTACTTACCTCATGTACAGAAGAGAATGGCATGGATCAAGAAAATCCCCCTTGT
GAAGAAGAATCAGCAGTTCTTGCTTTGTATAAAACACTTCACCAGTATACGGGAAGTGCCTTGAAAGAAATACCATCCGGCTGGCATCTG
TGGAGGAGTGTCAGAGCTGGAATCATGCCTTTCCTGAAGTGTTCTGCTTTATTTTTTCATTACTTAAATGGAGTTCCTTCCCCACCCGAC
ATTCAAGTTCCTGGAACAAGCCATTTTGAACATTTATGTAGCTATCTTTCCCTACCAAACAACCTCATTTGCCTTTTTCAAGAAAATAGT
GAGATAATGAATTCACTGATTGAAAGTTGGTGCCGTAACAGTGAAGTTAAAAGATATCTAGAAGGTGAAAGAGATGCTATAAGAACCCAC
AATACATTATATGCACCAGAAATGCTAGCCAAAATGGCAGAGCCTTTCACCAAGGCTCTGGATATGCTTGACGCGGAAAAATCTGCTATA
TTAGGATTACCTCAACCTCTCTTGGAACTCAATGACTCTCCTGTCTTCAAAACCGTCTTGGAAAGAATGCAGCGTTTCTTCTCTACCCTC
TATGAAAACTGTTTTCATATCCTAGGGAAGGCAGGCCCTTCCATGCAGCAAGACTTCTATACTGTGGAGGACCTTGCTACCCAGCTTCTC
AGCTCAGCCTTTGTCAACTTGAACAATATTCCTGACTACCGACTCAGACCCATGCTTCGTGTCTTTGTAAAGCCTCTGGTGCTCTTCTGT
CCCCCAGAGCACTATGAAGCCCTGGTATCCCCCATCCTCGGACCTCTTTTCACCTACCTCCATATGAGGCTTTCTCAGAAATGGCAAGTT
ATCAACCAAAGGAGCCTGCTGTGTGGAGAAGATGAGGCTGCAGATGAAAACCCAGAGTCTCAAGAGATGCTGGAGGAGCAACTGGTGAGG
ATGTTAACCCGAGAAGTCATGGACCTAATCACGGTTTGCTGTGTTTCAAAGAAGGGTGCTGACCACAGTAGTGCTCCCCCAGCAGATGGA
GACGATGAAGAAATGATGGCCACAGAGGTCACCCCCTCAGCTATGGCAGAGCTTACAGACCTGGGCAAATGTCTGATGAAGCATGAGGAT
GTTTGTACAGCGCTATTAATTACAGCCTTCAATTCCCTGGCCTGGAAAGATACTCTGTCCTGCCAGAGGACAACCTCACAGCTCTGCTGG
CCTCTCCTCAAACAAGTGCTGTCAGGGACACTGCTCGCAGATGCAGTTACGTGGCTTTTCACCAGTGTGCTGAAAGGCTTACAGATGCAC
GGGCAGCACGACGGGTGCATGGCTTCCCTGGTCCATCTGGCCTTCCAGATATACGAGGCACTGCGCCCCAGGTACCTGGAGATAAGAGCT
GTAATGGAGCAAATCCCTGAAATACAGAAGGACTCACTGGACCAGTTTGACTGCAAGCTTTTAAACCCCTCCCTGCAGAAAGTGGCTGAC
AAGCGCCGAAAGGACCAATTCAAACGCCTCATTGCTGGTTGCATTGGGAAACCCTTGGGAGAGCAGTTCCGAAAAGAAGTTCACATTAAG
AATCTTCCCTCACTTTTCAAAAAAACAAAGCCAATGCTGGAGACGGAGGTGCTGGACAATGATGGGGGTGGCCTGGCCACCATCTTTGAA
CCCTGAATCAAGCTTTTGGGCATCCTTCCTCGGCCTTTCTTGTCATCTCTTCTTTCCCTTTGTAGCCGATCTCTAGGCCCTTCTTGCACT
GCCACCTCACTTTCCACCACTGTCAGCCTGGAAAGAGATCCAGGTCTGGAGCTGGAGAGAACAGGCCCTGTGCAGGACCAGAAGTAATTA
TACTAAAGTATCAAGAAAGGGAGTTAGGGCTTAAACTATTCTGTCTAGATGTCCCAGATAGTTCCCATTCTACTTGGAGATTTGGCTTTT
CCAAGAAAAGCTAGAGCAGAGCAGCCCTTCTCCCACAAGCCCTCCCACCCCCGTGCAGCCACATACCTGTACAGAATGGTAACTAAGGGT
GCTGTGCCCAACCCTGCGACTAGCAAGGCTCGCAGCAAGAGCACAGCCCTCAACTACTTGTGCCAGAGTTTCTCTTGGACCACTCCAACT
CCCACTGAGCCCTTTTGCTGCTGGGCTGGCAGGAAACTTTCCCCACTCCCTAAGGGGCATGTCTGGGTTAGGTGCTAAGTGCTGAAGAGA
ACTTGGTCAGTTCTCTCAACTTTGCTTTGGGCAAGAATCTGGTCACCTGATGGGATCCATGGTACAGGCTACTGCTAAACTTGGCACAGT
ATCAAGTATAGTACCTCCAAGGACCAGGGCTGGGAAGTCTTTAGTGCTAACATCCCCTTTAGAGTTCACACATCTTGCCCTTCCATGAAT
GACCCCTCAGTCTGGCCTCCCCAGCCTCAAGGTCCACTCAGGCACAAGAGCCACAGTACCCTAGATAGTGTCACATGACACCGTTGTCAT
CCAAGGATAATACAGACCAACTAGGCTACATCTGTGATGAGCAGCTAGCAAAGCCGCTGGTCTTCTCCTAGGACTAAGTCCAGGTGCCTT
CCACAATCTCATGGTCTTTCAGGTCCCTGGTTACTTTTCTCAAAGGCCATTTCCAAAAGAATACATGCCTTCACATCACAACCTGTACTG
TGAGTCCATTCTAGAGGTCACTGAAAGGCCCTGTAAAGAGAGGACATGGATACGGGACCTGGCCCTGAGGTTATTACTGGCCGTAAGGCA
GAGTTAATCCATACAGAAACCAGTGTGTCCATGTGCTCTGCACAAAAACAGACCTGTTGTCCATCCAGTCCACTGACAAGAGGGTTTCCC
CGAGAGCCGAAGTGGACTGAAGCTACAGTTTTTAGCTGGTGCGGGCCACAGGCAGGGTCAGATTGAGAAGAAGCAAAGCTGGGGAAGCAG
AAGTTGGGAGTCTTGTGTTGCTCCCTCTTCCTGTGTGGTGCTCTGGGTTTCTGTGGATCGTGAAGGCGATCTCAAGAGTGTTTCCCTCCA
AACCTGATAGCTGCCTATTCCTGTCTGGTTGGGGCTGTGGAGGATGTAGTTGTATTTATTGCATTGTAATATTTTTAACATCCTGTGACT
TCATGCTAGAAATTTTCTATTGTTTATAGAAACTTTTTGTAGAAACATTAACTCTAAAGCACATCTGCATGTCAGTAAAAATCTCAGTTT

>96435_96435_2_UBR2-XPO5_UBR2_chr6_42650849_ENST00000372901_XPO5_chr6_43501744_ENST00000265351_length(amino acids)=2015AA_BP=1591
MASELEPEVQAIDRSLLECSAEEIAGKWLQATDLTREVYQHLAHYVPKIYCRGPNPFPQKEDMLAQHVLLGPMEWYLCGEDPAFGFPKLE
QANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPL
VHLSEDVIARTYNIFAITFRYAVEILTWEKESELPADLEMVEKSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRR
SVRYGDFQYCEQAKSVIVRNTSRQTKPLKVQVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLSDS
KLWKGARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYERLQSDYVTDDHDREFSVADLSVQIFTVPSLARMLITEENLMSIIIKTFMDHLR
HRDAQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKPTEWSDELRQKFLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTL
QMKLTHVISMMQDWCASDEKVLIEAYKKCLAVLMQCHGGYTDGEQPITLSICGHSVETIRYCVSQEKVSIHLPVSRLLAGLHVLLSKSEV
AYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDVVMLQTGVSMMDPNHFLMIMLSRFEL
YQIFSTPDYGKRFSSEITHKDVVQQNNTLIEEMLYLIIMLVGERFSPGVGQVNATDEIKREIIHQLSIKPMAHSELVKSLPEDENKETGM
ESVIEAVAHFKKPGLTGRGMYELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRQNREDTALPPPVLPPFCPLFASLVNILQSDVMLCI
MGTILQWAVEHNGYAWSESMLQRVLHLIGMALQEEKQHLENVTEEHVVTFTFTQKISKPGEAPKNSPSILAMLETLQNAPYLEVHKDMIR
WILKTFNAVKKMRESSPTSPVAETEGTIMEESSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDASTSAVLDH
SPVASDMTLTALGPAQTQVPEQRQFVTCILCQEEQEVKVESRAMVLAAFVQRSTVLSKNRSKFIQDPEKYDPLFMHPDLSCGTHTSSCGH
IMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRNIFNNRLNFSDQPNLTQWIRTISQQIKALQFL
RKEESTPNNASTKNSENVDELQLPEGFRPDFRPKIPYSESIKEMLTTFGTATYKVGLKVHPNEEDPRVPIMCWGSCAYTIQSIERILSDE
DKPLFGPLPCRLDDCLRSLTRFAAAHWTVASVSVVQGHFCKLFASLVPNDSHEELPCILDIDMFHLLVGLVLAFPALQCQDFSGISLGTG
DLHIFHLVTMAHIIQILLTSCTEENGMDQENPPCEEESAVLALYKTLHQYTGSALKEIPSGWHLWRSVRAGIMPFLKCSALFFHYLNGVP
SPPDIQVPGTSHFEHLCSYLSLPNNLICLFQENSEIMNSLIESWCRNSEVKRYLEGERDAIRTHNTLYAPEMLAKMAEPFTKALDMLDAE
KSAILGLPQPLLELNDSPVFKTVLERMQRFFSTLYENCFHILGKAGPSMQQDFYTVEDLATQLLSSAFVNLNNIPDYRLRPMLRVFVKPL
VLFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQLVRMLTREVMDLITVCCVSKKGADHSSAP
PADGDDEEMMATEVTPSAMAELTDLGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKG
LQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQKVADKRRKDQFKRLIAGCIGKPLGEQFRKE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UBR2-XPO5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for UBR2-XPO5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for UBR2-XPO5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source