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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BGN-MYL6 (FusionGDB2 ID:9645)

Fusion Gene Summary for BGN-MYL6

check button Fusion gene summary
Fusion gene informationFusion gene name: BGN-MYL6
Fusion gene ID: 9645
HgeneTgene
Gene symbol

BGN

MYL6

Gene ID

633

4637

Gene namebiglycanmyosin light chain 6
SynonymsDSPG1|MRLS|PG-S1|PGI|SEMDX|SLRR1AESMLC|LC17|LC17-GI|LC17-NM|LC17A|LC17B|MLC-3|MLC1SM|MLC3NM|MLC3SM
Cytomap

Xq28

12q13.2

Type of geneprotein-codingprotein-coding
Descriptionbiglycanbone/cartilage proteoglycan-Idermatan sulphate proteoglycan Ismall leucine-rich protein 1Amyosin light polypeptide 617 kDa myosin light chainmyosin light chain A3myosin light chain alkali 3myosin, light chain 6, alkali, smooth muscle and non-musclemyosin, light polypeptide 6, alkali, smooth muscle and non-muscle
Modification date2020032020200313
UniProtAcc

P21810

P14649

Ensembl transtripts involved in fusion geneENST00000480756, ENST00000331595, 
ENST00000293422, ENST00000348108, 
ENST00000548580, ENST00000550697, 
ENST00000536128, ENST00000547408, 
ENST00000547649, ENST00000548293, 
ENST00000548400, ENST00000549017, 
ENST00000549566, ENST00000551589, 
ENST00000551954, 
Fusion gene scores* DoF score18 X 9 X 12=194417 X 20 X 7=2380
# samples 1820
** MAII scorelog2(18/1944*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/2380*10)=-3.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BGN [Title/Abstract] AND MYL6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBGN(152772643)-MYL6(56552467), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BGN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-HZ-7926BGNchrX

152772643

+MYL6chr12

56552467

+


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Fusion Gene ORF analysis for BGN-MYL6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000480756ENST00000293422BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-3CDSENST00000480756ENST00000348108BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-3CDSENST00000480756ENST00000548580BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-3CDSENST00000480756ENST00000550697BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-5UTRENST00000480756ENST00000536128BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-5UTRENST00000480756ENST00000547408BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-5UTRENST00000480756ENST00000547649BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-5UTRENST00000480756ENST00000548293BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-5UTRENST00000480756ENST00000548400BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-5UTRENST00000480756ENST00000549017BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-5UTRENST00000480756ENST00000549566BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-5UTRENST00000480756ENST00000551589BGNchrX

152772643

+MYL6chr12

56552467

+
3UTR-intronENST00000480756ENST00000551954BGNchrX

152772643

+MYL6chr12

56552467

+
5CDS-5UTRENST00000331595ENST00000536128BGNchrX

152772643

+MYL6chr12

56552467

+
5CDS-5UTRENST00000331595ENST00000547408BGNchrX

152772643

+MYL6chr12

56552467

+
5CDS-5UTRENST00000331595ENST00000547649BGNchrX

152772643

+MYL6chr12

56552467

+
5CDS-5UTRENST00000331595ENST00000548293BGNchrX

152772643

+MYL6chr12

56552467

+
5CDS-5UTRENST00000331595ENST00000548400BGNchrX

152772643

+MYL6chr12

56552467

+
5CDS-5UTRENST00000331595ENST00000549017BGNchrX

152772643

+MYL6chr12

56552467

+
5CDS-5UTRENST00000331595ENST00000549566BGNchrX

152772643

+MYL6chr12

56552467

+
5CDS-5UTRENST00000331595ENST00000551589BGNchrX

152772643

+MYL6chr12

56552467

+
5CDS-intronENST00000331595ENST00000551954BGNchrX

152772643

+MYL6chr12

56552467

+
In-frameENST00000331595ENST00000293422BGNchrX

152772643

+MYL6chr12

56552467

+
In-frameENST00000331595ENST00000348108BGNchrX

152772643

+MYL6chr12

56552467

+
In-frameENST00000331595ENST00000548580BGNchrX

152772643

+MYL6chr12

56552467

+
In-frameENST00000331595ENST00000550697BGNchrX

152772643

+MYL6chr12

56552467

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000331595BGNchrX152772643+ENST00000550697MYL6chr1256552467+175210951861547453
ENST00000331595BGNchrX152772643+ENST00000548580MYL6chr1256552467+156410951861403405
ENST00000331595BGNchrX152772643+ENST00000293422MYL6chr1256552467+171010951861550454
ENST00000331595BGNchrX152772643+ENST00000348108MYL6chr1256552467+176810951861550454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000331595ENST00000550697BGNchrX152772643+MYL6chr1256552467+0.0044282160.99557173
ENST00000331595ENST00000548580BGNchrX152772643+MYL6chr1256552467+0.0040915250.9959085
ENST00000331595ENST00000293422BGNchrX152772643+MYL6chr1256552467+0.0047512750.99524873
ENST00000331595ENST00000348108BGNchrX152772643+MYL6chr1256552467+0.0042654020.99573463

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Fusion Genomic Features for BGN-MYL6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BGNchrX152772643+MYL6chr1256552464+0.86182680.1381733
BGNchrX152772643+MYL6chr1256552464+0.86182680.1381733

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BGN-MYL6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:152772643/chr12:56552467)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BGN

P21810

MYL6

P14649

FUNCTION: May be involved in collagen fiber assembly. {ECO:0000250}.FUNCTION: Regulatory light chain of myosin. Does not bind calcium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+7863_76303369.0Compositional biasNote=Cys-rich
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78103_126303369.0RepeatNote=LRR 2
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78127_150303369.0RepeatNote=LRR 3
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78151_171303369.0RepeatNote=LRR 4
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78172_195303369.0RepeatNote=LRR 5
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78196_220303369.0RepeatNote=LRR 6
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78221_241303369.0RepeatNote=LRR 7
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78242_265303369.0RepeatNote=LRR 8
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78266_289303369.0RepeatNote=LRR 9
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+7882_102303369.0RepeatNote=LRR 1
TgeneMYL6chrX:152772643chr12:56552467ENST0000054764906119_1511152.0DomainEF-hand 3
TgeneMYL6chrX:152772643chr12:56552467ENST00000547649067_421152.0DomainEF-hand 1
TgeneMYL6chrX:152772643chr12:56552467ENST000005476490684_1191152.0DomainEF-hand 2
TgeneMYL6chrX:152772643chr12:56552467ENST0000054829306119_1511152.0DomainEF-hand 3
TgeneMYL6chrX:152772643chr12:56552467ENST00000548293067_421152.0DomainEF-hand 1
TgeneMYL6chrX:152772643chr12:56552467ENST000005482930684_1191152.0DomainEF-hand 2
TgeneMYL6chrX:152772643chr12:56552467ENST0000055069707119_1511133.33333333333334DomainEF-hand 3
TgeneMYL6chrX:152772643chr12:56552467ENST00000550697077_421133.33333333333334DomainEF-hand 1
TgeneMYL6chrX:152772643chr12:56552467ENST000005506970784_1191133.33333333333334DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78290_312303369.0RepeatNote=LRR 10
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78313_342303369.0RepeatNote=LRR 11
HgeneBGNchrX:152772643chr12:56552467ENST00000331595+78343_368303369.0RepeatNote=LRR 12


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Fusion Gene Sequence for BGN-MYL6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9645_9645_1_BGN-MYL6_BGN_chrX_152772643_ENST00000331595_MYL6_chr12_56552467_ENST00000293422_length(transcript)=1710nt_BP=1095nt
CCTGCCCAGCCTTTAGCCTCCCGCCCGCCGCCTCTGTCTCCCTCTCTCCACAAACTGCCCAGGAGTGAGTAGCTGCTTTCGGTCCGCCGG
ACACACCGGACAGATAGACGTGCGGACGGCCCACCACCCCAGCCCGCCAACTAGTCAGCCTGCGCCTGGCGCCTCCCCTCTCCAGGTCCA
TCCGCCATGTGGCCCCTGTGGCGCCTCGTGTCTCTGCTGGCCCTGAGCCAGGCCCTGCCCTTTGAGCAGAGAGGCTTCTGGGACTTCACC
CTGGACGATGGGCCATTCATGATGAACGATGAGGAAGCTTCGGGCGCTGACACCTCGGGCGTCCTGGACCCGGACTCTGTCACACCCACC
TACAGCGCCATGTGTCCTTTCGGCTGCCACTGCCACCTGCGGGTGGTTCAGTGCTCCGACCTGGGTCTGAAGTCTGTGCCCAAAGAGATC
TCCCCTGACACCACGCTGCTGGACCTGCAGAACAACGACATCTCCGAGCTCCGCAAGGATGACTTCAAGGGTCTCCAGCACCTCTACGCC
CTCGTCCTGGTGAACAACAAGATCTCCAAGATCCATGAGAAGGCCTTCAGCCCACTGCGGAAGCTGCAGAAGCTCTACATCTCCAAGAAC
CACCTGGTGGAGATCCCGCCCAACCTACCCAGCTCCCTGGTGGAGCTCCGCATCCACGACAACCGCATCCGCAAGGTGCCCAAGGGAGTG
TTCAGCGGGCTCCGGAACATGAACTGCATCGAGATGGGCGGGAACCCACTGGAGAACAGTGGCTTTGAACCTGGAGCCTTCGATGGCCTG
AAGCTCAACTACCTGCGCATCTCAGAGGCCAAGCTGACTGGCATCCCCAAAGACCTCCCTGAGACCCTGAATGAACTCCACCTAGACCAC
AACAAAATCCAGGCCATCGAACTGGAGGACCTGCTTCGCTACTCCAAGCTGTACAGGCTGGGCCTAGGCCACAACCAGATCAGGATGATC
GAGAACGGGAGCCTGAGCTTCCTGCCCACCCTCCGGGAGCTCCACTTGGACAACAACAAGTTGGCCAGGGTGCCCTCAGGGCTCCCAGAC
CTCAAGCTCCTCCAGCAGTGTGACTTCACCGAAGACCAGACCGCAGAGTTCAAGGAGGCCTTCCAGCTGTTTGACCGAACAGGTGATGGC
AAGATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCC
AAGAGTGATGAGATGAATGTGAAGGTGCTGGACTTTGAGCACTTTCTGCCCATGCTGCAGACAGTGGCCAAGAACAAGGACCAGGGCACC
TATGAGGATTATGTCGAAGGACTTCGGGTGTTTGACAAGGAAGGAAATGGCACCGTCATGGGTGCTGAAATCCGGCATGTTCTTGTCACA
CTGGGTGAGAAGATGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATGAGGACAGCAATGGTTGTATCAACTATGAAGAGCTCGTC
CGCATGGTGCTGAATGGCTGAGGACCTTCCCAGTCTCCCCAGAGTCCGTGCCTTTCCCTGTGTGAATTTTGTATCTAGCCTAAAGTTTCC
CTAGGCTTTCTTGTCTCAGCAACTTTCCCATCTTGTCTCTCTTGGATGATGTTTGCCGTCAGCATTCACCAAATAAACTTGCTCTCTGGG

>9645_9645_1_BGN-MYL6_BGN_chrX_152772643_ENST00000331595_MYL6_chr12_56552467_ENST00000293422_length(amino acids)=454AA_BP=303
MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISP
DTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFS
GLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIEN
GSLSFLPTLRELHLDNNKLARVPSGLPDLKLLQQCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKS
DEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEELVRM

--------------------------------------------------------------
>9645_9645_2_BGN-MYL6_BGN_chrX_152772643_ENST00000331595_MYL6_chr12_56552467_ENST00000348108_length(transcript)=1768nt_BP=1095nt
CCTGCCCAGCCTTTAGCCTCCCGCCCGCCGCCTCTGTCTCCCTCTCTCCACAAACTGCCCAGGAGTGAGTAGCTGCTTTCGGTCCGCCGG
ACACACCGGACAGATAGACGTGCGGACGGCCCACCACCCCAGCCCGCCAACTAGTCAGCCTGCGCCTGGCGCCTCCCCTCTCCAGGTCCA
TCCGCCATGTGGCCCCTGTGGCGCCTCGTGTCTCTGCTGGCCCTGAGCCAGGCCCTGCCCTTTGAGCAGAGAGGCTTCTGGGACTTCACC
CTGGACGATGGGCCATTCATGATGAACGATGAGGAAGCTTCGGGCGCTGACACCTCGGGCGTCCTGGACCCGGACTCTGTCACACCCACC
TACAGCGCCATGTGTCCTTTCGGCTGCCACTGCCACCTGCGGGTGGTTCAGTGCTCCGACCTGGGTCTGAAGTCTGTGCCCAAAGAGATC
TCCCCTGACACCACGCTGCTGGACCTGCAGAACAACGACATCTCCGAGCTCCGCAAGGATGACTTCAAGGGTCTCCAGCACCTCTACGCC
CTCGTCCTGGTGAACAACAAGATCTCCAAGATCCATGAGAAGGCCTTCAGCCCACTGCGGAAGCTGCAGAAGCTCTACATCTCCAAGAAC
CACCTGGTGGAGATCCCGCCCAACCTACCCAGCTCCCTGGTGGAGCTCCGCATCCACGACAACCGCATCCGCAAGGTGCCCAAGGGAGTG
TTCAGCGGGCTCCGGAACATGAACTGCATCGAGATGGGCGGGAACCCACTGGAGAACAGTGGCTTTGAACCTGGAGCCTTCGATGGCCTG
AAGCTCAACTACCTGCGCATCTCAGAGGCCAAGCTGACTGGCATCCCCAAAGACCTCCCTGAGACCCTGAATGAACTCCACCTAGACCAC
AACAAAATCCAGGCCATCGAACTGGAGGACCTGCTTCGCTACTCCAAGCTGTACAGGCTGGGCCTAGGCCACAACCAGATCAGGATGATC
GAGAACGGGAGCCTGAGCTTCCTGCCCACCCTCCGGGAGCTCCACTTGGACAACAACAAGTTGGCCAGGGTGCCCTCAGGGCTCCCAGAC
CTCAAGCTCCTCCAGCAGTGTGACTTCACCGAAGACCAGACCGCAGAGTTCAAGGAGGCCTTCCAGCTGTTTGACCGAACAGGTGATGGC
AAGATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCC
AAGAGTGATGAGATGAATGTGAAGGTGCTGGACTTTGAGCACTTTCTGCCCATGCTGCAGACAGTGGCCAAGAACAAGGACCAGGGCACC
TATGAGGATTATGTCGAAGGACTTCGGGTGTTTGACAAGGAAGGAAATGGCACCGTCATGGGTGCTGAAATCCGGCATGTTCTTGTCACA
CTGGGTGAGAAGATGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATGAGGACAGCAATGGTTGTATCAACTATGAAGCGTTTGTG
AGGCATATCCTGTCGGGGTGACGGGCCCATGGGGCGGAGCTCGTCCGCATGGTGCTGAATGGCTGAGGACCTTCCCAGTCTCCCCAGAGT
CCGTGCCTTTCCCTGTGTGAATTTTGTATCTAGCCTAAAGTTTCCCTAGGCTTTCTTGTCTCAGCAACTTTCCCATCTTGTCTCTCTTGG

>9645_9645_2_BGN-MYL6_BGN_chrX_152772643_ENST00000331595_MYL6_chr12_56552467_ENST00000348108_length(amino acids)=454AA_BP=303
MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISP
DTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFS
GLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIEN
GSLSFLPTLRELHLDNNKLARVPSGLPDLKLLQQCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKS
DEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRH

--------------------------------------------------------------
>9645_9645_3_BGN-MYL6_BGN_chrX_152772643_ENST00000331595_MYL6_chr12_56552467_ENST00000548580_length(transcript)=1564nt_BP=1095nt
CCTGCCCAGCCTTTAGCCTCCCGCCCGCCGCCTCTGTCTCCCTCTCTCCACAAACTGCCCAGGAGTGAGTAGCTGCTTTCGGTCCGCCGG
ACACACCGGACAGATAGACGTGCGGACGGCCCACCACCCCAGCCCGCCAACTAGTCAGCCTGCGCCTGGCGCCTCCCCTCTCCAGGTCCA
TCCGCCATGTGGCCCCTGTGGCGCCTCGTGTCTCTGCTGGCCCTGAGCCAGGCCCTGCCCTTTGAGCAGAGAGGCTTCTGGGACTTCACC
CTGGACGATGGGCCATTCATGATGAACGATGAGGAAGCTTCGGGCGCTGACACCTCGGGCGTCCTGGACCCGGACTCTGTCACACCCACC
TACAGCGCCATGTGTCCTTTCGGCTGCCACTGCCACCTGCGGGTGGTTCAGTGCTCCGACCTGGGTCTGAAGTCTGTGCCCAAAGAGATC
TCCCCTGACACCACGCTGCTGGACCTGCAGAACAACGACATCTCCGAGCTCCGCAAGGATGACTTCAAGGGTCTCCAGCACCTCTACGCC
CTCGTCCTGGTGAACAACAAGATCTCCAAGATCCATGAGAAGGCCTTCAGCCCACTGCGGAAGCTGCAGAAGCTCTACATCTCCAAGAAC
CACCTGGTGGAGATCCCGCCCAACCTACCCAGCTCCCTGGTGGAGCTCCGCATCCACGACAACCGCATCCGCAAGGTGCCCAAGGGAGTG
TTCAGCGGGCTCCGGAACATGAACTGCATCGAGATGGGCGGGAACCCACTGGAGAACAGTGGCTTTGAACCTGGAGCCTTCGATGGCCTG
AAGCTCAACTACCTGCGCATCTCAGAGGCCAAGCTGACTGGCATCCCCAAAGACCTCCCTGAGACCCTGAATGAACTCCACCTAGACCAC
AACAAAATCCAGGCCATCGAACTGGAGGACCTGCTTCGCTACTCCAAGCTGTACAGGCTGGGCCTAGGCCACAACCAGATCAGGATGATC
GAGAACGGGAGCCTGAGCTTCCTGCCCACCCTCCGGGAGCTCCACTTGGACAACAACAAGTTGGCCAGGGTGCCCTCAGGGCTCCCAGAC
CTCAAGCTCCTCCAGTGTGACTTCACCGAAGACCAGACCGCAGAGATGAATGTGAAGGTGCTGGACTTTGAGCACTTTCTGCCCATGCTG
CAGACAGTGGCCAAGAACAAGGACCAGGGCACCTATGAGGATTATGTCGAAGGACTTCGGGTGTTTGACAAGGAAGGAAATGGCACCGTC
ATGGGTGCTGAAATCCGGCATGTTCTTGTCACACTGGGTGAGAAGATGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATGAGGAC
AGCAATGGTTGTATCAACTATGAAGAGCTCGTCCGCATGGTGCTGAATGGCTGAGGACCTTCCCAGTCTCCCCAGAGTCCGTGCCTTTCC
CTGTGTGAATTTTGTATCTAGCCTAAAGTTTCCCTAGGCTTTCTTGTCTCAGCAACTTTCCCATCTTGTCTCTCTTGGATGATGTTTGCC

>9645_9645_3_BGN-MYL6_BGN_chrX_152772643_ENST00000331595_MYL6_chr12_56552467_ENST00000548580_length(amino acids)=405AA_BP=302
MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISP
DTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFS
GLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIEN
GSLSFLPTLRELHLDNNKLARVPSGLPDLKLLQCDFTEDQTAEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMG

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>9645_9645_4_BGN-MYL6_BGN_chrX_152772643_ENST00000331595_MYL6_chr12_56552467_ENST00000550697_length(transcript)=1752nt_BP=1095nt
CCTGCCCAGCCTTTAGCCTCCCGCCCGCCGCCTCTGTCTCCCTCTCTCCACAAACTGCCCAGGAGTGAGTAGCTGCTTTCGGTCCGCCGG
ACACACCGGACAGATAGACGTGCGGACGGCCCACCACCCCAGCCCGCCAACTAGTCAGCCTGCGCCTGGCGCCTCCCCTCTCCAGGTCCA
TCCGCCATGTGGCCCCTGTGGCGCCTCGTGTCTCTGCTGGCCCTGAGCCAGGCCCTGCCCTTTGAGCAGAGAGGCTTCTGGGACTTCACC
CTGGACGATGGGCCATTCATGATGAACGATGAGGAAGCTTCGGGCGCTGACACCTCGGGCGTCCTGGACCCGGACTCTGTCACACCCACC
TACAGCGCCATGTGTCCTTTCGGCTGCCACTGCCACCTGCGGGTGGTTCAGTGCTCCGACCTGGGTCTGAAGTCTGTGCCCAAAGAGATC
TCCCCTGACACCACGCTGCTGGACCTGCAGAACAACGACATCTCCGAGCTCCGCAAGGATGACTTCAAGGGTCTCCAGCACCTCTACGCC
CTCGTCCTGGTGAACAACAAGATCTCCAAGATCCATGAGAAGGCCTTCAGCCCACTGCGGAAGCTGCAGAAGCTCTACATCTCCAAGAAC
CACCTGGTGGAGATCCCGCCCAACCTACCCAGCTCCCTGGTGGAGCTCCGCATCCACGACAACCGCATCCGCAAGGTGCCCAAGGGAGTG
TTCAGCGGGCTCCGGAACATGAACTGCATCGAGATGGGCGGGAACCCACTGGAGAACAGTGGCTTTGAACCTGGAGCCTTCGATGGCCTG
AAGCTCAACTACCTGCGCATCTCAGAGGCCAAGCTGACTGGCATCCCCAAAGACCTCCCTGAGACCCTGAATGAACTCCACCTAGACCAC
AACAAAATCCAGGCCATCGAACTGGAGGACCTGCTTCGCTACTCCAAGCTGTACAGGCTGGGCCTAGGCCACAACCAGATCAGGATGATC
GAGAACGGGAGCCTGAGCTTCCTGCCCACCCTCCGGGAGCTCCACTTGGACAACAACAAGTTGGCCAGGGTGCCCTCAGGGCTCCCAGAC
CTCAAGCTCCTCCAGTGTGACTTCACCGAAGACCAGACCGCAGAGTTCAAGGAGGCCTTCCAGCTGTTTGACCGAACAGGTGATGGCAAG
ATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAAG
AGTGATGAGATGAATGTGAAGGTGCTGGACTTTGAGCACTTTCTGCCCATGCTGCAGACAGTGGCCAAGAACAAGGACCAGGGCACCTAT
GAGGATTATGTCGAAGGACTTCGGGTGTTTGACAAGGAAGGAAATGGCACCGTCATGGGTGCTGAAATCCGGCATGTTCTTGTCACACTG
GGTGAGAAGATGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATGAGGACAGCAATGGTTGTATCAACTATGAAGCGTTTGTGAGG
CATATCCTGTCGGGGTGACGGGCCCATGGGGCGGAGCTCGTCCGCATGGTGCTGAATGGCTGAGGACCTTCCCAGTCTCCCCAGAGTCCG
TGCCTTTCCCTGTGTGAATTTTGTATCTAGCCTAAAGTTTCCCTAGGCTTTCTTGTCTCAGCAACTTTCCCATCTTGTCTCTCTTGGATG

>9645_9645_4_BGN-MYL6_BGN_chrX_152772643_ENST00000331595_MYL6_chr12_56552467_ENST00000550697_length(amino acids)=453AA_BP=302
MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISP
DTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFS
GLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIEN
GSLSFLPTLRELHLDNNKLARVPSGLPDLKLLQCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSD
EMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHI

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Fusion Gene PPI Analysis for BGN-MYL6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BGN-MYL6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BGN-MYL6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource