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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UBXN1-BSCL2 (FusionGDB2 ID:96509)

Fusion Gene Summary for UBXN1-BSCL2

check button Fusion gene summary
Fusion gene informationFusion gene name: UBXN1-BSCL2
Fusion gene ID: 96509
HgeneTgene
Gene symbol

UBXN1

BSCL2

Gene ID

51035

26580

Gene nameUBX domain protein 1BSCL2 lipid droplet biogenesis associated, seipin
Synonyms2B28|SAKS1|UBXD10GNG3LG|HMN5|PELD|SPG17
Cytomap

11q12.3

11q12.3

Type of geneprotein-codingprotein-coding
DescriptionUBX domain-containing protein 1SAPK substrate protein 1UBA/UBX 33.3 kDa proteinseipinBSCL2, seipin lipid droplet biogenesis associatedBerardinelli-Seip congenital lipodystrophy 2 (seipin)Bernardinelli-Seip congenital lipodystrophy type 2 protein
Modification date2020032020200327
UniProtAcc.

Q96G97

Ensembl transtripts involved in fusion geneENST00000294119, ENST00000301935, 
ENST00000529640, ENST00000533000, 
ENST00000524762, 		ENST00000537604, 
ENST00000278893, ENST00000360796, 
ENST00000403550, ENST00000405837, 
ENST00000407022, ENST00000421906, 
ENST00000433053, 
Fusion gene scores* DoF score4 X 4 X 3=4812 X 5 X 9=540
# samples 515
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/540*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBXN1 [Title/Abstract] AND BSCL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBXN1(62444990)-BSCL2(62460269), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBXN1

GO:0031397

negative regulation of protein ubiquitination

20351172

HgeneUBXN1

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

20351172

HgeneUBXN1

GO:1903094

negative regulation of protein K48-linked deubiquitination

21135095

HgeneUBXN1

GO:2000157

negative regulation of ubiquitin-specific protease activity

21135095


check buttonFusion gene breakpoints across UBXN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BSCL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A129-01AUBXN1chr11

62444990

-BSCL2chr11

62460269

-
ChimerDB4BRCATCGA-AO-A129UBXN1chr11

62444989

-BSCL2chr11

62460269

-


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Fusion Gene ORF analysis for UBXN1-BSCL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000294119ENST00000537604UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5CDS-intronENST00000294119ENST00000537604UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5CDS-intronENST00000301935ENST00000537604UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5CDS-intronENST00000301935ENST00000537604UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5CDS-intronENST00000529640ENST00000537604UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5CDS-intronENST00000529640ENST00000537604UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5CDS-intronENST00000533000ENST00000537604UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5CDS-intronENST00000533000ENST00000537604UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000278893UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000278893UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000360796UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000360796UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000403550UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000403550UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000405837UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000405837UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000407022UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000407022UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000421906UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000421906UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000433053UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5UTR-3CDSENST00000524762ENST00000433053UBXN1chr11

62444989

-BSCL2chr11

62460269

-
5UTR-intronENST00000524762ENST00000537604UBXN1chr11

62444990

-BSCL2chr11

62460269

-
5UTR-intronENST00000524762ENST00000537604UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000278893UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000278893UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000360796UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000360796UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000403550UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000403550UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000405837UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000405837UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000407022UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000407022UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000421906UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000421906UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000433053UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000294119ENST00000433053UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000278893UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000278893UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000360796UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000360796UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000403550UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000403550UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000405837UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000405837UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000407022UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000407022UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000421906UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000421906UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000433053UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000301935ENST00000433053UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000278893UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000278893UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000360796UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000360796UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000403550UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000403550UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000405837UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000405837UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000407022UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000407022UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000421906UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000421906UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000433053UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000529640ENST00000433053UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000278893UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000278893UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000360796UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000360796UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000403550UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000403550UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000405837UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000405837UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000407022UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000407022UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000421906UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000421906UBXN1chr11

62444989

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000433053UBXN1chr11

62444990

-BSCL2chr11

62460269

-
In-frameENST00000533000ENST00000433053UBXN1chr11

62444989

-BSCL2chr11

62460269

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for UBXN1-BSCL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBXN1-BSCL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:62444990/chr11:62460269)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BSCL2

Q96G97

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:19278620, PubMed:21533227, PubMed:31708432, PubMed:30293840). In association with TMEM159/LDAF1, defines the sites of LD formation in the ER (PubMed:31708432). Also required for growth and maturation of small nascent LDs into larger mature LDs (PubMed:27564575). Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs (PubMed:31178403, PubMed:27879284). Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts (PubMed:30970241). Binds anionic phospholipids including phosphatidic acid (PubMed:30293840). Plays an important role in the differentiation and development of adipocytes (By similarity). {ECO:0000250|UniProtKB:Q9Z2E9, ECO:0000269|PubMed:19278620, ECO:0000269|PubMed:21533227, ECO:0000269|PubMed:27564575, ECO:0000269|PubMed:27879284, ECO:0000269|PubMed:30293840, ECO:0000269|PubMed:30970241, ECO:0000269|PubMed:31178403, ECO:0000269|PubMed:31708432}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBXN1chr11:62444989chr11:62460269ENST00000294119-7887_172217313.0Coiled coilOntology_term=ECO:0000255
HgeneUBXN1chr11:62444989chr11:62460269ENST00000301935-7987_172217298.0Coiled coilOntology_term=ECO:0000255
HgeneUBXN1chr11:62444990chr11:62460269ENST00000294119-7887_172217313.0Coiled coilOntology_term=ECO:0000255
HgeneUBXN1chr11:62444990chr11:62460269ENST00000301935-7987_172217298.0Coiled coilOntology_term=ECO:0000255
HgeneUBXN1chr11:62444989chr11:62460269ENST00000294119-782_42217313.0DomainUBA
HgeneUBXN1chr11:62444989chr11:62460269ENST00000301935-792_42217298.0DomainUBA
HgeneUBXN1chr11:62444990chr11:62460269ENST00000294119-782_42217313.0DomainUBA
HgeneUBXN1chr11:62444990chr11:62460269ENST00000301935-792_42217298.0DomainUBA
TgeneBSCL2chr11:62444989chr11:62460269ENST00000278893310264_398146253.66666666666666Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST00000360796311264_398210463.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST00000403550311264_398146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST00000407022311264_398146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST00000421906311264_398146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST00000433053412264_398210463.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST00000278893310264_398146253.66666666666666Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST00000360796311264_398210463.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST00000403550311264_398146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST00000407022311264_398146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST00000421906311264_398146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST00000433053412264_398210463.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST00000278893310243_263146253.66666666666666TransmembraneHelical
TgeneBSCL2chr11:62444989chr11:62460269ENST00000360796311243_263210463.0TransmembraneHelical
TgeneBSCL2chr11:62444989chr11:62460269ENST00000403550311243_263146399.0TransmembraneHelical
TgeneBSCL2chr11:62444989chr11:62460269ENST00000407022311243_263146399.0TransmembraneHelical
TgeneBSCL2chr11:62444989chr11:62460269ENST00000421906311243_263146399.0TransmembraneHelical
TgeneBSCL2chr11:62444989chr11:62460269ENST00000433053412243_263210463.0TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST00000278893310243_263146253.66666666666666TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST00000360796311243_263210463.0TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST00000403550311243_263146399.0TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST00000407022311243_263146399.0TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST00000421906311243_263146399.0TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST00000433053412243_263210463.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBXN1chr11:62444989chr11:62460269ENST00000294119-78211_293217313.0DomainUBX
HgeneUBXN1chr11:62444989chr11:62460269ENST00000301935-79211_293217298.0DomainUBX
HgeneUBXN1chr11:62444990chr11:62460269ENST00000294119-78211_293217313.0DomainUBX
HgeneUBXN1chr11:62444990chr11:62460269ENST00000301935-79211_293217298.0DomainUBX
TgeneBSCL2chr11:62444989chr11:62460269ENST000002788933101_26146253.66666666666666Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST0000027889331048_242146253.66666666666666Topological domainLumenal
TgeneBSCL2chr11:62444989chr11:62460269ENST000003607963111_26210463.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST0000036079631148_242210463.0Topological domainLumenal
TgeneBSCL2chr11:62444989chr11:62460269ENST000004035503111_26146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST0000040355031148_242146399.0Topological domainLumenal
TgeneBSCL2chr11:62444989chr11:62460269ENST000004070223111_26146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST0000040702231148_242146399.0Topological domainLumenal
TgeneBSCL2chr11:62444989chr11:62460269ENST000004219063111_26146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST0000042190631148_242146399.0Topological domainLumenal
TgeneBSCL2chr11:62444989chr11:62460269ENST000004330534121_26210463.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444989chr11:62460269ENST0000043305341248_242210463.0Topological domainLumenal
TgeneBSCL2chr11:62444990chr11:62460269ENST000002788933101_26146253.66666666666666Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST0000027889331048_242146253.66666666666666Topological domainLumenal
TgeneBSCL2chr11:62444990chr11:62460269ENST000003607963111_26210463.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST0000036079631148_242210463.0Topological domainLumenal
TgeneBSCL2chr11:62444990chr11:62460269ENST000004035503111_26146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST0000040355031148_242146399.0Topological domainLumenal
TgeneBSCL2chr11:62444990chr11:62460269ENST000004070223111_26146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST0000040702231148_242146399.0Topological domainLumenal
TgeneBSCL2chr11:62444990chr11:62460269ENST000004219063111_26146399.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST0000042190631148_242146399.0Topological domainLumenal
TgeneBSCL2chr11:62444990chr11:62460269ENST000004330534121_26210463.0Topological domainCytoplasmic
TgeneBSCL2chr11:62444990chr11:62460269ENST0000043305341248_242210463.0Topological domainLumenal
TgeneBSCL2chr11:62444989chr11:62460269ENST0000027889331027_47146253.66666666666666TransmembraneHelical
TgeneBSCL2chr11:62444989chr11:62460269ENST0000036079631127_47210463.0TransmembraneHelical
TgeneBSCL2chr11:62444989chr11:62460269ENST0000040355031127_47146399.0TransmembraneHelical
TgeneBSCL2chr11:62444989chr11:62460269ENST0000040702231127_47146399.0TransmembraneHelical
TgeneBSCL2chr11:62444989chr11:62460269ENST0000042190631127_47146399.0TransmembraneHelical
TgeneBSCL2chr11:62444989chr11:62460269ENST0000043305341227_47210463.0TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST0000027889331027_47146253.66666666666666TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST0000036079631127_47210463.0TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST0000040355031127_47146399.0TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST0000040702231127_47146399.0TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST0000042190631127_47146399.0TransmembraneHelical
TgeneBSCL2chr11:62444990chr11:62460269ENST0000043305341227_47210463.0TransmembraneHelical


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Fusion Gene Sequence for UBXN1-BSCL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for UBXN1-BSCL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneUBXN1chr11:62444989chr11:62460269ENST00000294119-7843_297217.0313.0BRCA1
HgeneUBXN1chr11:62444989chr11:62460269ENST00000301935-7943_297217.0298.0BRCA1
HgeneUBXN1chr11:62444990chr11:62460269ENST00000294119-7843_297217.0313.0BRCA1
HgeneUBXN1chr11:62444990chr11:62460269ENST00000301935-7943_297217.0298.0BRCA1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UBXN1-BSCL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UBXN1-BSCL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource