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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UBXN4-SVIL (FusionGDB2 ID:96526)

Fusion Gene Summary for UBXN4-SVIL

check button Fusion gene summary
Fusion gene informationFusion gene name: UBXN4-SVIL
Fusion gene ID: 96526
HgeneTgene
Gene symbol

UBXN4

SVIL

Gene ID

23190

6840

Gene nameUBX domain protein 4supervillin
SynonymsUBXD2|UBXDC1|erasin-
Cytomap

2q21.3

10p11.23

Type of geneprotein-codingprotein-coding
DescriptionUBX domain-containing protein 4UBX domain containing 2UBX domain-containing 1UBX domain-containing protein 2supervillinarchvillinmembrane-associated F-actin binding protein p205p205/p250
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000272638, ENST00000490163, 
ENST00000460007, ENST00000538146, 
ENST00000355867, ENST00000375398, 
ENST00000375400, ENST00000535393, 
Fusion gene scores* DoF score5 X 9 X 6=27022 X 18 X 7=2772
# samples 1124
** MAII scorelog2(11/270*10)=-1.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2772*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBXN4 [Title/Abstract] AND SVIL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUBXN4(136511137)-SVIL(29777685), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across UBXN4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SVIL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GT-01AUBXN4chr2

136511137

+SVILchr10

29777685

-


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Fusion Gene ORF analysis for UBXN4-SVIL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000272638ENST00000460007UBXN4chr2

136511137

+SVILchr10

29777685

-
5CDS-intronENST00000272638ENST00000538146UBXN4chr2

136511137

+SVILchr10

29777685

-
In-frameENST00000272638ENST00000355867UBXN4chr2

136511137

+SVILchr10

29777685

-
In-frameENST00000272638ENST00000375398UBXN4chr2

136511137

+SVILchr10

29777685

-
In-frameENST00000272638ENST00000375400UBXN4chr2

136511137

+SVILchr10

29777685

-
In-frameENST00000272638ENST00000535393UBXN4chr2

136511137

+SVILchr10

29777685

-
intron-3CDSENST00000490163ENST00000355867UBXN4chr2

136511137

+SVILchr10

29777685

-
intron-3CDSENST00000490163ENST00000375398UBXN4chr2

136511137

+SVILchr10

29777685

-
intron-3CDSENST00000490163ENST00000375400UBXN4chr2

136511137

+SVILchr10

29777685

-
intron-3CDSENST00000490163ENST00000535393UBXN4chr2

136511137

+SVILchr10

29777685

-
intron-intronENST00000490163ENST00000460007UBXN4chr2

136511137

+SVILchr10

29777685

-
intron-intronENST00000490163ENST00000538146UBXN4chr2

136511137

+SVILchr10

29777685

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000272638UBXN4chr2136511137+ENST00000375400SVILchr1029777685-38875251582977939
ENST00000272638UBXN4chr2136511137+ENST00000375398SVILchr1029777685-38775251582977939
ENST00000272638UBXN4chr2136511137+ENST00000355867SVILchr1029777685-31665251582977939
ENST00000272638UBXN4chr2136511137+ENST00000535393SVILchr1029777685-31125251582977939

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000272638ENST00000375400UBXN4chr2136511137+SVILchr1029777685-0.0014227210.99857724
ENST00000272638ENST00000375398UBXN4chr2136511137+SVILchr1029777685-0.0014239640.99857605
ENST00000272638ENST00000355867UBXN4chr2136511137+SVILchr1029777685-0.0033465010.9966535
ENST00000272638ENST00000535393UBXN4chr2136511137+SVILchr1029777685-0.0038566270.9961434

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Fusion Genomic Features for UBXN4-SVIL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UBXN4-SVIL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:136511137/chr10:29777685)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSVILchr2:136511137chr10:29777685ENST0000035586721382151_221413972215.0DomainHP
TgeneSVILchr2:136511137chr10:29777685ENST0000037539823402151_221413972215.0DomainHP
TgeneSVILchr2:136511137chr10:29777685ENST0000037540019362151_22149711789.0DomainHP
TgeneSVILchr2:136511137chr10:29777685ENST0000035586721381441_154013972215.0RepeatNote=Gelsolin-like 1
TgeneSVILchr2:136511137chr10:29777685ENST0000035586721381560_168213972215.0RepeatNote=Gelsolin-like 2
TgeneSVILchr2:136511137chr10:29777685ENST0000035586721381752_186213972215.0RepeatNote=Gelsolin-like 3
TgeneSVILchr2:136511137chr10:29777685ENST0000035586721381881_198213972215.0RepeatNote=Gelsolin-like 4
TgeneSVILchr2:136511137chr10:29777685ENST0000035586721382015_212213972215.0RepeatNote=Gelsolin-like 5
TgeneSVILchr2:136511137chr10:29777685ENST0000037539823401441_154013972215.0RepeatNote=Gelsolin-like 1
TgeneSVILchr2:136511137chr10:29777685ENST0000037539823401560_168213972215.0RepeatNote=Gelsolin-like 2
TgeneSVILchr2:136511137chr10:29777685ENST0000037539823401752_186213972215.0RepeatNote=Gelsolin-like 3
TgeneSVILchr2:136511137chr10:29777685ENST0000037539823401881_198213972215.0RepeatNote=Gelsolin-like 4
TgeneSVILchr2:136511137chr10:29777685ENST0000037539823402015_212213972215.0RepeatNote=Gelsolin-like 5
TgeneSVILchr2:136511137chr10:29777685ENST0000037540019361441_15409711789.0RepeatNote=Gelsolin-like 1
TgeneSVILchr2:136511137chr10:29777685ENST0000037540019361560_16829711789.0RepeatNote=Gelsolin-like 2
TgeneSVILchr2:136511137chr10:29777685ENST0000037540019361752_18629711789.0RepeatNote=Gelsolin-like 3
TgeneSVILchr2:136511137chr10:29777685ENST0000037540019361881_19829711789.0RepeatNote=Gelsolin-like 4
TgeneSVILchr2:136511137chr10:29777685ENST0000037540019362015_21229711789.0RepeatNote=Gelsolin-like 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUBXN4chr2:136511137chr10:29777685ENST00000272638+313315_39371509.0DomainUBX
HgeneUBXN4chr2:136511137chr10:29777685ENST00000272638+313414_43471509.0IntramembraneOntology_term=ECO:0000255
HgeneUBXN4chr2:136511137chr10:29777685ENST00000272638+3131_41371509.0Topological domainCytoplasmic
HgeneUBXN4chr2:136511137chr10:29777685ENST00000272638+313435_50871509.0Topological domainCytoplasmic


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Fusion Gene Sequence for UBXN4-SVIL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96526_96526_1_UBXN4-SVIL_UBXN4_chr2_136511137_ENST00000272638_SVIL_chr10_29777685_ENST00000355867_length(transcript)=3166nt_BP=525nt
TTCCTCCACTTCCTGGACTGCGCGACCGGAGGCCTAGCGGGCGCGCGCCCGCACCATCGACTCGCCAACGAGAGAAGGTCCTGGGGCACG
GACACCGACGGGTTGCGACTGTGACGTGAGGTGTTCTCGCGCGCGCTAGCGCGCGTCTCCGGGTGCCGCTGACGGGCGTGCGCGCTTGTG
CGGAGCCGGAGGTGGGGGCCGAACCAGCCAAGGTTGCGGGGGCCGCAGAGCCGGACGAAGACGGAGGGCGGAGCCGGCTTCGGGACTGCG
GAGACTACACACCGAGCGAGCGCCTGGGCCCGAAGGGAGCGATGCTGTGGTTCCAGGGCGCCATTCCGGCCGCCATCGCGACGGCCAAAA
GGAGCGGCGCGGTCTTCGTGGTGTTCGTGGCAGGTGATGATGAACAGTCTACACAGATGGCTGCAAGTTGGGAAGATGATAAAGTTACAG
AAGCATCTTCAAACAGTTTTGTTGCTATTAAAATCGATACCAAAAGTGAAGCCTGCCTACAGTTTTCACAAATCTTGTCTTCCAACTCCA
ACTTCTCAGAAGTCACCCTGGCGGGTTTAGCCAGTAAAGAAAACTTCAGCAACGTCAGCCTGCGGAGCGTCAACCTGACGGAACAGAACT
CTAACAACAGCGCCGTGCCCTACAAGAGGCTGATGCTGTTGCAGATTAAAGGAAGAAGACATGTGCAGACCAGGCTGGTGGAACCTCGAG
CTTCGGCGCTCAACAGTGGGGACTGCTTCCTCCTGCTCTCTCCCCACTGCTGCTTCCTGTGGGTAGGAGAGTTTGCAAACGTCATAGAAA
AGGCGAAGGCCTCAGAACTTGCAACTTTAATTCAGACAAAGAGGGAACTTGGTTGTAGAGCTACTTATATCCAAACCATTGAAGAAGGAA
TTAATACACACACTCATGCAGCCAAAGACTTCTGGAAGCTTCTGGGTGGCCAAACCAGTTACCAATCTGCTGGAGACCCAAAAGAAGATG
AACTCTATGAAGCAGCCATAATAGAAACTAACTGCATTTACCGTCTCATGGATGACAAACTTGTTCCTGATGACGACTACTGGGGGAAAA
TTCCGAAGTGCTCCCTTCTGCAACCCAAAGAGGTACTGGTGTTTGATTTTGGTAGTGAAGTTTACGTATGGCATGGGAAAGAAGTCACAT
TAGCACAACGAAAAATAGCATTTCAGCTGGCAAAGCACTTATGGAATGGAACCTTTGACTATGAGAACTGTGACATCAATCCCCTGGATC
CTGGAGAATGCAATCCGCTTATCCCCAGAAAAGGACAGGGGCGGCCCGACTGGGCGATATTTGGGAGACTTACTGAACACAATGAGACGA
TTTTGTTCAAAGAGAAGTTTCTGGATTGGACGGAACTGAAGAGATCGAATGAGAAGAACCCCGGGGAACTTGCCCAGCACAAGGAAGACC
CCAGGACTGATGTCAAGGCATACGATGTGACACGGATGGTGTCCATGCCCCAGACGACAGCAGGCACCATCCTGGACGGAGTGAACGTCG
GCCGTGGCTATGGCCTGGTGGAAGGACACGACAGGAGGCAGTTTGAGATCACCAGCGTTTCCGTGGATGTCTGGCACATCCTGGAATTCG
ACTATAGCAGGCTCCCCAAACAAAGCATCGGGCAGTTCCATGAGGGGGATGCCTATGTGGTCAAGTGGAAGTTCATGGTGAGCACGGCAG
TGGGAAGTCGCCAGAAGGGAGAGCACTCGGTGAGGGCAGCCGGCAAAGAGAAGTGCGTCTACTTCTTCTGGCAAGGCCGGCACTCCACCG
TGAGTGAGAAGGGCACGTCGGCGCTGATGACGGTGGAGCTGGACGAGGAAAGGGGGGCCCAGGTCCAGGTTCTCCAGGGAAAGGAGCCCC
CCTGTTTCCTGCAGTGTTTCCAGGGGGGGATGGTGGTGCACTCGGGGAGGCGGGAAGAGGAAGAAGAAAATGTGCAAAGTGAGTGGCGGC
TGTACTGCGTGCGTGGAGAGGTGCCCGTGGAAGGGAATTTGCTGGAAGTGGCCTGTCACTGTAGCAGCCTGAGGTCCAGAACTTCCATGG
TGGTGCTTAACGTCAACAAGGCCCTCATCTACCTGTGGCACGGATGCAAAGCCCAGGCCCACACGAAGGAGGTCGGAAGGACCGCTGCGA
ACAAGATCAAGGAACAATGTCCCCTGGAAGCAGGACTGCATAGTAGCAGCAAAGTCACAATACACGAGTGTGATGAAGGCTCCGAGCCAC
TCGGATTCTGGGATGCCTTAGGAAGGAGAGACAGGAAAGCCTACGATTGCATGCTTCAAGATCCTGGAAGTTTTAACTTCGCGCCCCGCC
TGTTCATCCTCAGCAGCTCCTCTGGGGATTTTGCAGCCACAGAGTTTGTGTACCCTGCCCGAGCCCCCTCTGTGGTCAGTTCCATGCCCT
TCCTGCAGGAAGATCTGTACAGCGCGCCCCAGCCAGCACTTTTCCTTGTTGACAATCACCACGAGGTGTACCTCTGGCAAGGCTGGTGGC
CCATCGAGAACAAGATCACTGGTTCCGCCCGCATCCGCTGGGCCTCCGACCGGAAGAGTGCGATGGAGACTGTGCTCCAGTACTGCAAAG
GAAAAAATCTCAAGAAACCAGCCCCCAAGTCTTACCTTATCCACGCTGGTCTGGAGCCCCTGACATTCACCAATATGTTTCCCAGCTGGG
AGCACAGAGAGGACATCGCTGAGATCACAGAGATGGACACGGAAGTTTCCAATCAGATCACCCTCGTGGAAGACGTCTTAGCCAAGCTCT
GTAAAACCATTTACCCGCTGGCCGACCTCCTGGCCAGGCCACTCCCGGAGGGGGTCGATCCTCTGAAGCTTGAGATCTATCTCACCGACG
AAGACTTCGAGTTTGCACTAGACATGACGAGGGATGAATACAACGCCCTGCCCGCCTGGAAGCAGGTGAACCTGAAGAAAGCAAAAGGCC
TGTTCTGAGTGGGGAGACGCCAGAGGAGCCTCACGGTCACGTCCAACAACACCACTGCACCAGGGAAATGGATATATATTTTTGGACTGG
TGTTTTTCACAAAGTATTTTTCAATCAGAGTTTTCAGAACCTGACATTGTTAAAGATACTGCTTGTCCCGGAGTTGTGTATTTTGTAAAT

>96526_96526_1_UBXN4-SVIL_UBXN4_chr2_136511137_ENST00000272638_SVIL_chr10_29777685_ENST00000355867_length(amino acids)=939AA_BP=123
MTGVRACAEPEVGAEPAKVAGAAEPDEDGGRSRLRDCGDYTPSERLGPKGAMLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAAS
WEDDKVTEASSNSFVAIKIDTKSEACLQFSQILSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQ
TRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQS
AGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYEN
CDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGT
ILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFF
WQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSS
LRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPG
SFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAME
TVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLK

--------------------------------------------------------------
>96526_96526_2_UBXN4-SVIL_UBXN4_chr2_136511137_ENST00000272638_SVIL_chr10_29777685_ENST00000375398_length(transcript)=3877nt_BP=525nt
TTCCTCCACTTCCTGGACTGCGCGACCGGAGGCCTAGCGGGCGCGCGCCCGCACCATCGACTCGCCAACGAGAGAAGGTCCTGGGGCACG
GACACCGACGGGTTGCGACTGTGACGTGAGGTGTTCTCGCGCGCGCTAGCGCGCGTCTCCGGGTGCCGCTGACGGGCGTGCGCGCTTGTG
CGGAGCCGGAGGTGGGGGCCGAACCAGCCAAGGTTGCGGGGGCCGCAGAGCCGGACGAAGACGGAGGGCGGAGCCGGCTTCGGGACTGCG
GAGACTACACACCGAGCGAGCGCCTGGGCCCGAAGGGAGCGATGCTGTGGTTCCAGGGCGCCATTCCGGCCGCCATCGCGACGGCCAAAA
GGAGCGGCGCGGTCTTCGTGGTGTTCGTGGCAGGTGATGATGAACAGTCTACACAGATGGCTGCAAGTTGGGAAGATGATAAAGTTACAG
AAGCATCTTCAAACAGTTTTGTTGCTATTAAAATCGATACCAAAAGTGAAGCCTGCCTACAGTTTTCACAAATCTTGTCTTCCAACTCCA
ACTTCTCAGAAGTCACCCTGGCGGGTTTAGCCAGTAAAGAAAACTTCAGCAACGTCAGCCTGCGGAGCGTCAACCTGACGGAACAGAACT
CTAACAACAGCGCCGTGCCCTACAAGAGGCTGATGCTGTTGCAGATTAAAGGAAGAAGACATGTGCAGACCAGGCTGGTGGAACCTCGAG
CTTCGGCGCTCAACAGTGGGGACTGCTTCCTCCTGCTCTCTCCCCACTGCTGCTTCCTGTGGGTAGGAGAGTTTGCAAACGTCATAGAAA
AGGCGAAGGCCTCAGAACTTGCAACTTTAATTCAGACAAAGAGGGAACTTGGTTGTAGAGCTACTTATATCCAAACCATTGAAGAAGGAA
TTAATACACACACTCATGCAGCCAAAGACTTCTGGAAGCTTCTGGGTGGCCAAACCAGTTACCAATCTGCTGGAGACCCAAAAGAAGATG
AACTCTATGAAGCAGCCATAATAGAAACTAACTGCATTTACCGTCTCATGGATGACAAACTTGTTCCTGATGACGACTACTGGGGGAAAA
TTCCGAAGTGCTCCCTTCTGCAACCCAAAGAGGTACTGGTGTTTGATTTTGGTAGTGAAGTTTACGTATGGCATGGGAAAGAAGTCACAT
TAGCACAACGAAAAATAGCATTTCAGCTGGCAAAGCACTTATGGAATGGAACCTTTGACTATGAGAACTGTGACATCAATCCCCTGGATC
CTGGAGAATGCAATCCGCTTATCCCCAGAAAAGGACAGGGGCGGCCCGACTGGGCGATATTTGGGAGACTTACTGAACACAATGAGACGA
TTTTGTTCAAAGAGAAGTTTCTGGATTGGACGGAACTGAAGAGATCGAATGAGAAGAACCCCGGGGAACTTGCCCAGCACAAGGAAGACC
CCAGGACTGATGTCAAGGCATACGATGTGACACGGATGGTGTCCATGCCCCAGACGACAGCAGGCACCATCCTGGACGGAGTGAACGTCG
GCCGTGGCTATGGCCTGGTGGAAGGACACGACAGGAGGCAGTTTGAGATCACCAGCGTTTCCGTGGATGTCTGGCACATCCTGGAATTCG
ACTATAGCAGGCTCCCCAAACAAAGCATCGGGCAGTTCCATGAGGGGGATGCCTATGTGGTCAAGTGGAAGTTCATGGTGAGCACGGCAG
TGGGAAGTCGCCAGAAGGGAGAGCACTCGGTGAGGGCAGCCGGCAAAGAGAAGTGCGTCTACTTCTTCTGGCAAGGCCGGCACTCCACCG
TGAGTGAGAAGGGCACGTCGGCGCTGATGACGGTGGAGCTGGACGAGGAAAGGGGGGCCCAGGTCCAGGTTCTCCAGGGAAAGGAGCCCC
CCTGTTTCCTGCAGTGTTTCCAGGGGGGGATGGTGGTGCACTCGGGGAGGCGGGAAGAGGAAGAAGAAAATGTGCAAAGTGAGTGGCGGC
TGTACTGCGTGCGTGGAGAGGTGCCCGTGGAAGGGAATTTGCTGGAAGTGGCCTGTCACTGTAGCAGCCTGAGGTCCAGAACTTCCATGG
TGGTGCTTAACGTCAACAAGGCCCTCATCTACCTGTGGCACGGATGCAAAGCCCAGGCCCACACGAAGGAGGTCGGAAGGACCGCTGCGA
ACAAGATCAAGGAACAATGTCCCCTGGAAGCAGGACTGCATAGTAGCAGCAAAGTCACAATACACGAGTGTGATGAAGGCTCCGAGCCAC
TCGGATTCTGGGATGCCTTAGGAAGGAGAGACAGGAAAGCCTACGATTGCATGCTTCAAGATCCTGGAAGTTTTAACTTCGCGCCCCGCC
TGTTCATCCTCAGCAGCTCCTCTGGGGATTTTGCAGCCACAGAGTTTGTGTACCCTGCCCGAGCCCCCTCTGTGGTCAGTTCCATGCCCT
TCCTGCAGGAAGATCTGTACAGCGCGCCCCAGCCAGCACTTTTCCTTGTTGACAATCACCACGAGGTGTACCTCTGGCAAGGCTGGTGGC
CCATCGAGAACAAGATCACTGGTTCCGCCCGCATCCGCTGGGCCTCCGACCGGAAGAGTGCGATGGAGACTGTGCTCCAGTACTGCAAAG
GAAAAAATCTCAAGAAACCAGCCCCCAAGTCTTACCTTATCCACGCTGGTCTGGAGCCCCTGACATTCACCAATATGTTTCCCAGCTGGG
AGCACAGAGAGGACATCGCTGAGATCACAGAGATGGACACGGAAGTTTCCAATCAGATCACCCTCGTGGAAGACGTCTTAGCCAAGCTCT
GTAAAACCATTTACCCGCTGGCCGACCTCCTGGCCAGGCCACTCCCGGAGGGGGTCGATCCTCTGAAGCTTGAGATCTATCTCACCGACG
AAGACTTCGAGTTTGCACTAGACATGACGAGGGATGAATACAACGCCCTGCCCGCCTGGAAGCAGGTGAACCTGAAGAAAGCAAAAGGCC
TGTTCTGAGTGGGGAGACGCCAGAGGAGCCTCACGGTCACGTCCAACAACACCACTGCACCAGGGAAATGGATATATATTTTTGGACTGG
TGTTTTTCACAAAGTATTTTTCAATCAGAGTTTTCAGAACCTGACATTGTTAAAGATACTGCTTGTCCCGGAGTTGTGTATTTTGTAAAT
GTTCAAGGGAACTGTTTGGAAACTTCTTTCCACCATTCAGGAGGTTATCAGAATTAATAAAAGTATCTGTTATGTGCACTTAAGCCGCAG
CTGCTATAGATAGCACTGCCTTCTTGTTCCAGCTAGGCAATGCCTTTTTTTTTTTTTTTTGAAGCAGTTCTCTTTATAAAGTGTTATTTT
GATAGTTTGTGGATTCTAAAATATATATATATTTATATAAACACCATATAAGTCAAATATGTATTTAACAAAGCAATATGTATTCATTCA
CTTTCAAGATTTGTTTTGGTGTCAAAATAACATGAAAAGGTAGATGGAGTTGCTTCTGTTGAATTAGCTCTGCCACCAATATGTATCTTC
ATACACGTTTGGAAATGTTTCCTGCAGCATTAGGTATGACTTGTTCTGAGTACTGCTTCCGGTGCTAAAATGAACAAAGAATTTGTACTT
AATGGCATGGACTCTGGAGAATCTATGCGAATCAACCTTTCTACCTTAATATCTCCCCAAAAATGTATAGTGCCTTGTTTTTATGTACAG
TTTATATACAGAAAAGTTTGCTCTGCATTTTTGATGATGGTTTGGAACATTATCTACAATTTTACTCTCAAATAGTCAAAATAAAAACAT
CTCAATTTCTAATACCGGTTGTAAACAGTACACATGTCATTTTGTGATATAGGACTCCCAAATAAAAGTATCAGAATAAACACAACAATT

>96526_96526_2_UBXN4-SVIL_UBXN4_chr2_136511137_ENST00000272638_SVIL_chr10_29777685_ENST00000375398_length(amino acids)=939AA_BP=123
MTGVRACAEPEVGAEPAKVAGAAEPDEDGGRSRLRDCGDYTPSERLGPKGAMLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAAS
WEDDKVTEASSNSFVAIKIDTKSEACLQFSQILSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQ
TRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQS
AGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYEN
CDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGT
ILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFF
WQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSS
LRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPG
SFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAME
TVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLK

--------------------------------------------------------------
>96526_96526_3_UBXN4-SVIL_UBXN4_chr2_136511137_ENST00000272638_SVIL_chr10_29777685_ENST00000375400_length(transcript)=3887nt_BP=525nt
TTCCTCCACTTCCTGGACTGCGCGACCGGAGGCCTAGCGGGCGCGCGCCCGCACCATCGACTCGCCAACGAGAGAAGGTCCTGGGGCACG
GACACCGACGGGTTGCGACTGTGACGTGAGGTGTTCTCGCGCGCGCTAGCGCGCGTCTCCGGGTGCCGCTGACGGGCGTGCGCGCTTGTG
CGGAGCCGGAGGTGGGGGCCGAACCAGCCAAGGTTGCGGGGGCCGCAGAGCCGGACGAAGACGGAGGGCGGAGCCGGCTTCGGGACTGCG
GAGACTACACACCGAGCGAGCGCCTGGGCCCGAAGGGAGCGATGCTGTGGTTCCAGGGCGCCATTCCGGCCGCCATCGCGACGGCCAAAA
GGAGCGGCGCGGTCTTCGTGGTGTTCGTGGCAGGTGATGATGAACAGTCTACACAGATGGCTGCAAGTTGGGAAGATGATAAAGTTACAG
AAGCATCTTCAAACAGTTTTGTTGCTATTAAAATCGATACCAAAAGTGAAGCCTGCCTACAGTTTTCACAAATCTTGTCTTCCAACTCCA
ACTTCTCAGAAGTCACCCTGGCGGGTTTAGCCAGTAAAGAAAACTTCAGCAACGTCAGCCTGCGGAGCGTCAACCTGACGGAACAGAACT
CTAACAACAGCGCCGTGCCCTACAAGAGGCTGATGCTGTTGCAGATTAAAGGAAGAAGACATGTGCAGACCAGGCTGGTGGAACCTCGAG
CTTCGGCGCTCAACAGTGGGGACTGCTTCCTCCTGCTCTCTCCCCACTGCTGCTTCCTGTGGGTAGGAGAGTTTGCAAACGTCATAGAAA
AGGCGAAGGCCTCAGAACTTGCAACTTTAATTCAGACAAAGAGGGAACTTGGTTGTAGAGCTACTTATATCCAAACCATTGAAGAAGGAA
TTAATACACACACTCATGCAGCCAAAGACTTCTGGAAGCTTCTGGGTGGCCAAACCAGTTACCAATCTGCTGGAGACCCAAAAGAAGATG
AACTCTATGAAGCAGCCATAATAGAAACTAACTGCATTTACCGTCTCATGGATGACAAACTTGTTCCTGATGACGACTACTGGGGGAAAA
TTCCGAAGTGCTCCCTTCTGCAACCCAAAGAGGTACTGGTGTTTGATTTTGGTAGTGAAGTTTACGTATGGCATGGGAAAGAAGTCACAT
TAGCACAACGAAAAATAGCATTTCAGCTGGCAAAGCACTTATGGAATGGAACCTTTGACTATGAGAACTGTGACATCAATCCCCTGGATC
CTGGAGAATGCAATCCGCTTATCCCCAGAAAAGGACAGGGGCGGCCCGACTGGGCGATATTTGGGAGACTTACTGAACACAATGAGACGA
TTTTGTTCAAAGAGAAGTTTCTGGATTGGACGGAACTGAAGAGATCGAATGAGAAGAACCCCGGGGAACTTGCCCAGCACAAGGAAGACC
CCAGGACTGATGTCAAGGCATACGATGTGACACGGATGGTGTCCATGCCCCAGACGACAGCAGGCACCATCCTGGACGGAGTGAACGTCG
GCCGTGGCTATGGCCTGGTGGAAGGACACGACAGGAGGCAGTTTGAGATCACCAGCGTTTCCGTGGATGTCTGGCACATCCTGGAATTCG
ACTATAGCAGGCTCCCCAAACAAAGCATCGGGCAGTTCCATGAGGGGGATGCCTATGTGGTCAAGTGGAAGTTCATGGTGAGCACGGCAG
TGGGAAGTCGCCAGAAGGGAGAGCACTCGGTGAGGGCAGCCGGCAAAGAGAAGTGCGTCTACTTCTTCTGGCAAGGCCGGCACTCCACCG
TGAGTGAGAAGGGCACGTCGGCGCTGATGACGGTGGAGCTGGACGAGGAAAGGGGGGCCCAGGTCCAGGTTCTCCAGGGAAAGGAGCCCC
CCTGTTTCCTGCAGTGTTTCCAGGGGGGGATGGTGGTGCACTCGGGGAGGCGGGAAGAGGAAGAAGAAAATGTGCAAAGTGAGTGGCGGC
TGTACTGCGTGCGTGGAGAGGTGCCCGTGGAAGGGAATTTGCTGGAAGTGGCCTGTCACTGTAGCAGCCTGAGGTCCAGAACTTCCATGG
TGGTGCTTAACGTCAACAAGGCCCTCATCTACCTGTGGCACGGATGCAAAGCCCAGGCCCACACGAAGGAGGTCGGAAGGACCGCTGCGA
ACAAGATCAAGGAACAATGTCCCCTGGAAGCAGGACTGCATAGTAGCAGCAAAGTCACAATACACGAGTGTGATGAAGGCTCCGAGCCAC
TCGGATTCTGGGATGCCTTAGGAAGGAGAGACAGGAAAGCCTACGATTGCATGCTTCAAGATCCTGGAAGTTTTAACTTCGCGCCCCGCC
TGTTCATCCTCAGCAGCTCCTCTGGGGATTTTGCAGCCACAGAGTTTGTGTACCCTGCCCGAGCCCCCTCTGTGGTCAGTTCCATGCCCT
TCCTGCAGGAAGATCTGTACAGCGCGCCCCAGCCAGCACTTTTCCTTGTTGACAATCACCACGAGGTGTACCTCTGGCAAGGCTGGTGGC
CCATCGAGAACAAGATCACTGGTTCCGCCCGCATCCGCTGGGCCTCCGACCGGAAGAGTGCGATGGAGACTGTGCTCCAGTACTGCAAAG
GAAAAAATCTCAAGAAACCAGCCCCCAAGTCTTACCTTATCCACGCTGGTCTGGAGCCCCTGACATTCACCAATATGTTTCCCAGCTGGG
AGCACAGAGAGGACATCGCTGAGATCACAGAGATGGACACGGAAGTTTCCAATCAGATCACCCTCGTGGAAGACGTCTTAGCCAAGCTCT
GTAAAACCATTTACCCGCTGGCCGACCTCCTGGCCAGGCCACTCCCGGAGGGGGTCGATCCTCTGAAGCTTGAGATCTATCTCACCGACG
AAGACTTCGAGTTTGCACTAGACATGACGAGGGATGAATACAACGCCCTGCCCGCCTGGAAGCAGGTGAACCTGAAGAAAGCAAAAGGCC
TGTTCTGAGTGGGGAGACGCCAGAGGAGCCTCACGGTCACGTCCAACAACACCACTGCACCAGGGAAATGGATATATATTTTTGGACTGG
TGTTTTTCACAAAGTATTTTTCAATCAGAGTTTTCAGAACCTGACATTGTTAAAGATACTGCTTGTCCCGGAGTTGTGTATTTTGTAAAT
GTTCAAGGGAACTGTTTGGAAACTTCTTTCCACCATTCAGGAGGTTATCAGAATTAATAAAAGTATCTGTTATGTGCACTTAAGCCGCAG
CTGCTATAGATAGCACTGCCTTCTTGTTCCAGCTAGGCAATGCCTTTTTTTTTTTTTTTTGAAGCAGTTCTCTTTATAAAGTGTTATTTT
GATAGTTTGTGGATTCTAAAATATATATATATTTATATAAACACCATATAAGTCAAATATGTATTTAACAAAGCAATATGTATTCATTCA
CTTTCAAGATTTGTTTTGGTGTCAAAATAACATGAAAAGGTAGATGGAGTTGCTTCTGTTGAATTAGCTCTGCCACCAATATGTATCTTC
ATACACGTTTGGAAATGTTTCCTGCAGCATTAGGTATGACTTGTTCTGAGTACTGCTTCCGGTGCTAAAATGAACAAAGAATTTGTACTT
AATGGCATGGACTCTGGAGAATCTATGCGAATCAACCTTTCTACCTTAATATCTCCCCAAAAATGTATAGTGCCTTGTTTTTATGTACAG
TTTATATACAGAAAAGTTTGCTCTGCATTTTTGATGATGGTTTGGAACATTATCTACAATTTTACTCTCAAATAGTCAAAATAAAAACAT
CTCAATTTCTAATACCGGTTGTAAACAGTACACATGTCATTTTGTGATATAGGACTCCCAAATAAAAGTATCAGAATAAACACAACAATT

>96526_96526_3_UBXN4-SVIL_UBXN4_chr2_136511137_ENST00000272638_SVIL_chr10_29777685_ENST00000375400_length(amino acids)=939AA_BP=123
MTGVRACAEPEVGAEPAKVAGAAEPDEDGGRSRLRDCGDYTPSERLGPKGAMLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAAS
WEDDKVTEASSNSFVAIKIDTKSEACLQFSQILSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQ
TRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQS
AGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYEN
CDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGT
ILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFF
WQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSS
LRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPG
SFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAME
TVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLK

--------------------------------------------------------------
>96526_96526_4_UBXN4-SVIL_UBXN4_chr2_136511137_ENST00000272638_SVIL_chr10_29777685_ENST00000535393_length(transcript)=3112nt_BP=525nt
TTCCTCCACTTCCTGGACTGCGCGACCGGAGGCCTAGCGGGCGCGCGCCCGCACCATCGACTCGCCAACGAGAGAAGGTCCTGGGGCACG
GACACCGACGGGTTGCGACTGTGACGTGAGGTGTTCTCGCGCGCGCTAGCGCGCGTCTCCGGGTGCCGCTGACGGGCGTGCGCGCTTGTG
CGGAGCCGGAGGTGGGGGCCGAACCAGCCAAGGTTGCGGGGGCCGCAGAGCCGGACGAAGACGGAGGGCGGAGCCGGCTTCGGGACTGCG
GAGACTACACACCGAGCGAGCGCCTGGGCCCGAAGGGAGCGATGCTGTGGTTCCAGGGCGCCATTCCGGCCGCCATCGCGACGGCCAAAA
GGAGCGGCGCGGTCTTCGTGGTGTTCGTGGCAGGTGATGATGAACAGTCTACACAGATGGCTGCAAGTTGGGAAGATGATAAAGTTACAG
AAGCATCTTCAAACAGTTTTGTTGCTATTAAAATCGATACCAAAAGTGAAGCCTGCCTACAGTTTTCACAAATCTTGTCTTCCAACTCCA
ACTTCTCAGAAGTCACCCTGGCGGGTTTAGCCAGTAAAGAAAACTTCAGCAACGTCAGCCTGCGGAGCGTCAACCTGACGGAACAGAACT
CTAACAACAGCGCCGTGCCCTACAAGAGGCTGATGCTGTTGCAGATTAAAGGAAGAAGACATGTGCAGACCAGGCTGGTGGAACCTCGAG
CTTCGGCGCTCAACAGTGGGGACTGCTTCCTCCTGCTCTCTCCCCACTGCTGCTTCCTGTGGGTAGGAGAGTTTGCAAACGTCATAGAAA
AGGCGAAGGCCTCAGAACTTGCAACTTTAATTCAGACAAAGAGGGAACTTGGTTGTAGAGCTACTTATATCCAAACCATTGAAGAAGGAA
TTAATACACACACTCATGCAGCCAAAGACTTCTGGAAGCTTCTGGGTGGCCAAACCAGTTACCAATCTGCTGGAGACCCAAAAGAAGATG
AACTCTATGAAGCAGCCATAATAGAAACTAACTGCATTTACCGTCTCATGGATGACAAACTTGTTCCTGATGACGACTACTGGGGGAAAA
TTCCGAAGTGCTCCCTTCTGCAACCCAAAGAGGTACTGGTGTTTGATTTTGGTAGTGAAGTTTACGTATGGCATGGGAAAGAAGTCACAT
TAGCACAACGAAAAATAGCATTTCAGCTGGCAAAGCACTTATGGAATGGAACCTTTGACTATGAGAACTGTGACATCAATCCCCTGGATC
CTGGAGAATGCAATCCGCTTATCCCCAGAAAAGGACAGGGGCGGCCCGACTGGGCGATATTTGGGAGACTTACTGAACACAATGAGACGA
TTTTGTTCAAAGAGAAGTTTCTGGATTGGACGGAACTGAAGAGATCGAATGAGAAGAACCCCGGGGAACTTGCCCAGCACAAGGAAGACC
CCAGGACTGATGTCAAGGCATACGATGTGACACGGATGGTGTCCATGCCCCAGACGACAGCAGGCACCATCCTGGACGGAGTGAACGTCG
GCCGTGGCTATGGCCTGGTGGAAGGACACGACAGGAGGCAGTTTGAGATCACCAGCGTTTCCGTGGATGTCTGGCACATCCTGGAATTCG
ACTATAGCAGGCTCCCCAAACAAAGCATCGGGCAGTTCCATGAGGGGGATGCCTATGTGGTCAAGTGGAAGTTCATGGTGAGCACGGCAG
TGGGAAGTCGCCAGAAGGGAGAGCACTCGGTGAGGGCAGCCGGCAAAGAGAAGTGCGTCTACTTCTTCTGGCAAGGCCGGCACTCCACCG
TGAGTGAGAAGGGCACGTCGGCGCTGATGACGGTGGAGCTGGACGAGGAAAGGGGGGCCCAGGTCCAGGTTCTCCAGGGAAAGGAGCCCC
CCTGTTTCCTGCAGTGTTTCCAGGGGGGGATGGTGGTGCACTCGGGGAGGCGGGAAGAGGAAGAAGAAAATGTGCAAAGTGAGTGGCGGC
TGTACTGCGTGCGTGGAGAGGTGCCCGTGGAAGGGAATTTGCTGGAAGTGGCCTGTCACTGTAGCAGCCTGAGGTCCAGAACTTCCATGG
TGGTGCTTAACGTCAACAAGGCCCTCATCTACCTGTGGCACGGATGCAAAGCCCAGGCCCACACGAAGGAGGTCGGAAGGACCGCTGCGA
ACAAGATCAAGGAACAATGTCCCCTGGAAGCAGGACTGCATAGTAGCAGCAAAGTCACAATACACGAGTGTGATGAAGGCTCCGAGCCAC
TCGGATTCTGGGATGCCTTAGGAAGGAGAGACAGGAAAGCCTACGATTGCATGCTTCAAGATCCTGGAAGTTTTAACTTCGCGCCCCGCC
TGTTCATCCTCAGCAGCTCCTCTGGGGATTTTGCAGCCACAGAGTTTGTGTACCCTGCCCGAGCCCCCTCTGTGGTCAGTTCCATGCCCT
TCCTGCAGGAAGATCTGTACAGCGCGCCCCAGCCAGCACTTTTCCTTGTTGACAATCACCACGAGGTGTACCTCTGGCAAGGCTGGTGGC
CCATCGAGAACAAGATCACTGGTTCCGCCCGCATCCGCTGGGCCTCCGACCGGAAGAGTGCGATGGAGACTGTGCTCCAGTACTGCAAAG
GAAAAAATCTCAAGAAACCAGCCCCCAAGTCTTACCTTATCCACGCTGGTCTGGAGCCCCTGACATTCACCAATATGTTTCCCAGCTGGG
AGCACAGAGAGGACATCGCTGAGATCACAGAGATGGACACGGAAGTTTCCAATCAGATCACCCTCGTGGAAGACGTCTTAGCCAAGCTCT
GTAAAACCATTTACCCGCTGGCCGACCTCCTGGCCAGGCCACTCCCGGAGGGGGTCGATCCTCTGAAGCTTGAGATCTATCTCACCGACG
AAGACTTCGAGTTTGCACTAGACATGACGAGGGATGAATACAACGCCCTGCCCGCCTGGAAGCAGGTGAACCTGAAGAAAGCAAAAGGCC
TGTTCTGAGTGGGGAGACGCCAGAGGAGCCTCACGGTCACGTCCAACAACACCACTGCACCAGGGAAATGGATATATATTTTTGGACTGG

>96526_96526_4_UBXN4-SVIL_UBXN4_chr2_136511137_ENST00000272638_SVIL_chr10_29777685_ENST00000535393_length(amino acids)=939AA_BP=123
MTGVRACAEPEVGAEPAKVAGAAEPDEDGGRSRLRDCGDYTPSERLGPKGAMLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAAS
WEDDKVTEASSNSFVAIKIDTKSEACLQFSQILSSNSNFSEVTLAGLASKENFSNVSLRSVNLTEQNSNNSAVPYKRLMLLQIKGRRHVQ
TRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQS
AGDPKEDELYEAAIIETNCIYRLMDDKLVPDDDYWGKIPKCSLLQPKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYEN
CDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGT
ILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGKEKCVYFF
WQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSS
LRSRTSMVVLNVNKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPG
SFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAME
TVLQYCKGKNLKKPAPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for UBXN4-SVIL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSVILchr2:136511137chr10:29777685ENST0000035586721381419_16871397.33333333333332215.0NEB
TgeneSVILchr2:136511137chr10:29777685ENST0000037539823401419_16871397.33333333333332215.0NEB
TgeneSVILchr2:136511137chr10:29777685ENST0000037540019361419_1687971.33333333333341789.0NEB


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneUBXN4chr2:136511137chr10:29777685ENST00000272638+3131_20071.33333333333333509.0UBQLN1
TgeneSVILchr2:136511137chr10:29777685ENST0000035586721381_1741397.33333333333332215.0MYLK
TgeneSVILchr2:136511137chr10:29777685ENST0000037539823401_1741397.33333333333332215.0MYLK
TgeneSVILchr2:136511137chr10:29777685ENST0000037540019361_174971.33333333333341789.0MYLK


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UBXN4-SVIL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UBXN4-SVIL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource