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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UCHL5-SLC6A17 (FusionGDB2 ID:96556)

Fusion Gene Summary for UCHL5-SLC6A17

check button Fusion gene summary
Fusion gene informationFusion gene name: UCHL5-SLC6A17
Fusion gene ID: 96556
HgeneTgene
Gene symbol

UCHL5

SLC6A17

Gene ID

51377

388662

Gene nameubiquitin C-terminal hydrolase L5solute carrier family 6 member 17
SynonymsCGI-70|INO80R|UCH-L5|UCH37MRT48|NTT4
Cytomap

1q31.2

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin carboxyl-terminal hydrolase isozyme L5INO80 complex subunit Rubiquitin C-terminal hydrolase UCH37ubiquitin carboxyl-terminal esterase L5ubiquitin carboxyl-terminal hydrolase L5ubiquitin thioesterase L5sodium-dependent neutral amino acid transporter SLC6A17orphan sodium- and chloride-dependent neurotransmitter transporter NTT4
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000367448, ENST00000367449, 
ENST00000367451, ENST00000367454, 
ENST00000367455, ENST00000367452, 
ENST00000483156, ENST00000530098, 
ENST00000465159, ENST00000331565, 
Fusion gene scores* DoF score6 X 5 X 5=1502 X 2 X 2=8
# samples 72
** MAII scorelog2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: UCHL5 [Title/Abstract] AND SLC6A17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUCHL5(193018875)-SLC6A17(110734593), # samples:1
Anticipated loss of major functional domain due to fusion event.UCHL5-SLC6A17 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
UCHL5-SLC6A17 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
UCHL5-SLC6A17 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
UCHL5-SLC6A17 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUCHL5

GO:0016579

protein deubiquitination

18922472


check buttonFusion gene breakpoints across UCHL5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC6A17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EOUCHL5chr1

193018875

-SLC6A17chr1

110734593

+


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Fusion Gene ORF analysis for UCHL5-SLC6A17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000367448ENST00000465159UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
5CDS-intronENST00000367449ENST00000465159UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
5CDS-intronENST00000367451ENST00000465159UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
5CDS-intronENST00000367454ENST00000465159UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
5CDS-intronENST00000367455ENST00000465159UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
5UTR-3CDSENST00000367452ENST00000331565UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
5UTR-intronENST00000367452ENST00000465159UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
Frame-shiftENST00000367448ENST00000331565UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
In-frameENST00000367449ENST00000331565UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
In-frameENST00000367451ENST00000331565UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
In-frameENST00000367454ENST00000331565UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
In-frameENST00000367455ENST00000331565UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
intron-3CDSENST00000483156ENST00000331565UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
intron-3CDSENST00000530098ENST00000331565UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
intron-intronENST00000483156ENST00000465159UCHL5chr1

193018875

-SLC6A17chr1

110734593

+
intron-intronENST00000530098ENST00000465159UCHL5chr1

193018875

-SLC6A17chr1

110734593

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367455UCHL5chr1193018875-ENST00000331565SLC6A17chr1110734593+5560482111801596
ENST00000367454UCHL5chr1193018875-ENST00000331565SLC6A17chr1110734593+5560482111801596
ENST00000367451UCHL5chr1193018875-ENST00000331565SLC6A17chr1110734593+541333551654549
ENST00000367449UCHL5chr1193018875-ENST00000331565SLC6A17chr1110734593+5473395141714566

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367455ENST00000331565UCHL5chr1193018875-SLC6A17chr1110734593+0.0028912140.99710876
ENST00000367454ENST00000331565UCHL5chr1193018875-SLC6A17chr1110734593+0.0028912140.99710876
ENST00000367451ENST00000331565UCHL5chr1193018875-SLC6A17chr1110734593+0.0056124230.99438757
ENST00000367449ENST00000331565UCHL5chr1193018875-SLC6A17chr1110734593+0.0054505260.99454945

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Fusion Genomic Features for UCHL5-SLC6A17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
UCHL5chr1193018875-SLC6A17chr1110734593+2.39E-091
UCHL5chr1193018875-SLC6A17chr1110734593+2.39E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for UCHL5-SLC6A17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:193018875/chr1:110734593)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512322_334288728.0Topological domainCytoplasmic
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512356_460288728.0Topological domainExtracellular
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512482_490288728.0Topological domainCytoplasmic
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512512_527288728.0Topological domainExtracellular
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512549_573288728.0Topological domainCytoplasmic
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512595_617288728.0Topological domainExtracellular
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512639_727288728.0Topological domainCytoplasmic
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512301_321288728.0TransmembraneHelical%3B Name%3D6
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512335_355288728.0TransmembraneHelical%3B Name%3D7
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512461_481288728.0TransmembraneHelical%3B Name%3D8
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512491_511288728.0TransmembraneHelical%3B Name%3D9
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512528_548288728.0TransmembraneHelical%3B Name%3D10
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512574_594288728.0TransmembraneHelical%3B Name%3D11
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512618_638288728.0TransmembraneHelical%3B Name%3D12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512117_147288728.0Topological domainCytoplasmic
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512169_222288728.0Topological domainExtracellular
TgeneSLC6A17chr1:193018875chr1:110734593ENST000003315655121_69288728.0Topological domainCytoplasmic
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512244_253288728.0Topological domainCytoplasmic
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512275_300288728.0Topological domainExtracellular
TgeneSLC6A17chr1:193018875chr1:110734593ENST0000033156551291_95288728.0Topological domainExtracellular
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512148_168288728.0TransmembraneHelical%3B Name%3D3
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512223_243288728.0TransmembraneHelical%3B Name%3D4
TgeneSLC6A17chr1:193018875chr1:110734593ENST00000331565512254_274288728.0TransmembraneHelical%3B Name%3D5
TgeneSLC6A17chr1:193018875chr1:110734593ENST0000033156551270_90288728.0TransmembraneHelical%3B Name%3D1
TgeneSLC6A17chr1:193018875chr1:110734593ENST0000033156551296_116288728.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for UCHL5-SLC6A17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96556_96556_1_UCHL5-SLC6A17_UCHL5_chr1_193018875_ENST00000367449_SLC6A17_chr1_110734593_ENST00000331565_length(transcript)=5473nt_BP=395nt
ACGGCGCCCGGAGGCTGTCGGGAAGTAGGCGGGGTGACGTGTGGTTGACGAGCTCGGCGGCGGGTTTGCTGAGATCTGTGGCCGGCGGCA
GCTGGTGCGGGGGGCAGCTGAGAGCGAGAGGTGGATCGGGGCGGTGTGTGGCCAGGGCCATGACGGGCAATGCCGGGGAGTGGTGCCTCA
TGGAAAGCGACCCCGGGGTCTTCACCGAGCTCATTAAAGGATTCGGTTGCCGAGGAGCCCAAGTAGAAGAAATATGGAGTTTAGAGCCTG
AGAATTTTGAAAAATTAAAGCCAGTTCATGGGTTAATTTTTCTTTTCAAGTGGCAGCCAGGAGAAGAACCAGCAGGCTCTGTGGTTCAGG
ACTCCCGACTTGACACGATATTTTTTGCTAAGCAGCTGGACAAGATGCTGGACCCCCAGGTGTGGCGGGAGGCAGCTACCCAGGTCTTCT
TTGCCTTGGGCCTGGGCTTTGGTGGTGTCATTGCCTTCTCCAGCTACAATAAGCAGGACAACAACTGCCACTTCGATGCCGCCCTGGTGT
CCTTCATCAACTTCTTCACGTCAGTGTTGGCCACCCTCGTGGTGTTTGCTGTGCTGGGCTTCAAGGCCAACATCATGAATGAGAAGTGTG
TGGTCGAGAATGCTGAGAAAATCCTAGGGTACCTTAACACCAACGTCCTGAGCCGGGACCTCATCCCACCCCACGTCAACTTCTCCCACC
TGACCACAAAGGACTACATGGAGATGTACAATGTCATCATGACCGTGAAGGAGGACCAGTTCTCAGCCCTGGGCCTTGACCCCTGCCTTC
TGGAGGACGAGCTGGACAAGTCCGTGCAGGGCACAGGCCTGGCCTTCATCGCCTTCACTGAGGCCATGACGCACTTCCCCGCCTCCCCGT
TCTGGTCCGTCATGTTCTTCTTGATGCTTATCAACCTGGGCCTGGGCAGCATGATCGGGACCATGGCAGGCATCACCACGCCCATCATCG
ACACCTTCAAGGTGCCCAAGGAGATGTTCACAGTGGGCTGCTGTGTCTTTGCATTCCTCGTGGGGCTGTTGTTCGTCCAGCGCTCCGGAA
ACTACTTTGTCACCATGTTCGATGACTACTCGGCCACCCTGCCACTCACTCTCATCGTCATCCTTGAGAACATCGCTGTGGCCTGGATTT
ATGGAACCAAGAAGTTCATGCAGGAGCTGACGGAGATGCTGGGCTTCCGCCCCTACCGCTTCTATTTCTACATGTGGAAGTTCGTGTCTC
CACTATGCATGGCTGTGCTCACCACAGCCAGCATCATCCAGCTGGGGGTCACGCCCCCGGGCTACAGCGCCTGGATCAAGGAGGAGGCTG
CCGAGCGCTACCTGTATTTCCCCAACTGGGCCATGGCACTCCTGATCACCCTCATCGTCGTGGCGACGCTGCCCATCCCTGTGGTGTTCG
TCCTGCGGCACTTCCACCTGCTCTCTGATGGCTCCAACACCCTCTCCGTGTCCTACAAGAAGGGCCGCATGATGAAGGACATCTCCAACC
TGGAGGAGAACGATGAGACCCGCTTCATCCTCAGCAAGGTGCCCAGTGAGGCACCTTCCCCCATGCCCACTCACCGTTCCTATCTGGGGC
CCGGCAGCACATCACCCCTGGAGACCAGCGGTAACCCCAATGGACGCTATGGGAGCGGCTACCTGCTGGCCAGCACCCCTGAGTCGGAGC
TGTGACCACTGCCCAAGCCCTGCCCGCCTCTCCCCCCACGCTCAACCTGCCCACTTGTCCAGGCCTGGCCTCTTTCTTGAGGTGGCCACC
AGGCCCAGGCCAGGCCCTTTGCCCAAGAAGAGAGGGTCTGCCCTGCCTCACTCCCCTCTTCAGTCCCAGTAGACTCTGCTCCCTAGCCCT
GAGCAGGAGGCTGGGAGCAGCTCTGTTTCCTAATTCAGGACCCCACTCATCTAGCCCTCCAAGAGCCTCCGCCAAATTGTAGCCATGTAA
TTGGAACAACCCATAAGGCCTGCTTCCCAGTCCATGGGAGATTCCAAGTGGCCACTGCAGGAGTCACTCACCTCCCTCTCTCCCTGTAAC
TTGCCACCTGCAGTTCTTAGGGCTGTGGGGTCAGATGGTGGTGGTGAGAGGCCTTGGGGCTGGGGAAGGAGAGTGGACTTTGGCTCACTC
TGCCATGAGAACAGGACACCATCCTGCCCAGCCCAGACGGGGTTGCTCCTGGTCCAAGAGGCTACCTGCTCCAAGGCGGAGGGTGGGAGC
AGGTGTGCCAGGGCTCAGGGCTCAGACTTGGGAGGGCCTAGGCAGAAGCCCCAAGTTCTGTTTTCTGAGGTATGTGCTGCCCTTGGCTTC
AGCATGAGCCTTGGTAGCAGAAGGTGAGGAACCTCCTCTGCCCTGGTCCCTGGGTGGAATCTTCCCATGTCCTTGGCCCTGCCTGGGGTG
TGTGGTGTGTGCTCCTGCATCTTGTCTGGGAGTGCAGTGACCGGGACCAGAACCTTCCCCACCTCAATTAGGGCTTAGCCATCTCCCTGT
CCCCAGCACCCCTCCCCAGCCCACAGTGGTGGCCTCTGCCTCTTTCCTGGAGAGAGAAGGACAGTGCACGGAGAGGTTTCCAGAGCACAA
ATTGTTGGTTCCTAGCACAAATTAGATGGTTTGGAGCACAATGGTGAAGCACACTCCCCTCCCTCCTCACCTGGGGTCCAATGTTCTGTC
TAGTGGCAGCTTTTCCCCTGGAACAGGGGTCCCTGGAGTTCACAGGCTTATCCCCAGGAAGCCTCACTCCTGGGGAAAGACAGATAATTT
CACTGCCCCTTTGAGCCACCACTCACTCTCCTTATTACACAAGCACAGCCGCCCAGTGTGCACATCATGTGCAGACACCTTGGAAACCTT
TCCCAAGCCTTCCTGGCCCACAGTGGCCAGTGCCATAGGCAGTGCTGTGGACAGTAGAGGCTGCCAAAGGCAAGGGCTGGTCTTCAGGAT
GGAGGCCAGCCTGTGCAGAAGGCTGCAGCTGACAACAGCGACCCCACCTGCCATTACCTTCAGGGCCTCCTCTGGAAGAGAACCCATTCT
CAGAGTGCAGCCAGGGAGGAACCTGACCCAAGAGTAAATGTCTGCAGAGAGATGGATGGATGGATGGATAGATGGATGGATGGGTTGGGG
AGTGGGGGTGGATGGATGGATAGATGGATGGATGGATGGATGGATGGGTTGGGGGGTGGGGGTGGATGGATAGATGGATGGATGGATGGA
CGGATGGGGTGGGGGAAGGAAGGAAAGGAGGGAGAAAGGAGGGAATACTGGCTCCATCTTTGAGAGCTCTGGTGGGCAGGGCAGAAACAG
GCCACAGTGCTCAACCCGGACACCCTCACGAAGGGTCGCAAGTCACTCTTGTGGCTCAGATTGCTCTTAGGACCTGGAGGGACAGACCAG
AATCAGGGTCCCCTCCTTTACCCCTGAGTTCCTTACTGTTCCCCCAAGCCTGGGAGCAGTCTATCCCCCAACCCTGCCATCTCCCTTACT
CATCCCTCTTCCACAGCTTCCCCTTTCTAGCCCCCTCTGCCCTACCTGTCTTTCCTGAGTGTTTGAGGGGAGAGAGAGACCCACATCTCC
CCAAAGAGATGAGCTTTTGGGGCACAACATCCCACCGCAGTCCCCCTCACCCGACAACACCTCCTACCTGGCCCCTTGCCAAATCCCAAG
CAGAATTAGCAACAGGAAAAGCAGAGCCCCAGGAGAGACACTCTACTATATATACTCTTCTATATATTCTGTTTCTATTGTATATTCACT
CTGTACATGTGGGTGTAAATGCTGTTAAATGACAAACCCAATATTATACTGTGGCTGGTGGACTATTTTCATCCTCAGTGCTGTACAGAT
CTATTTTCATTGTATATTTGATATATTTTTAATTTTGTAGCGTGTGGCTGGGCCAGGCCCCAGCGGGAGGGGCTGAGCTGGGGCTGTGTG
CTTGCTAGGTGTGGGCGCGCTAGTGCTCGTTGTAGCCTTTTGCTGTGTCTTCGCTGTGTGTTAGACGTAGGGCCTAGAGCTCGGGGTGTG
TGTGTGCGTGCTGTGTGTATGGTGTGCACATACGTGAGTGTGGGTGTGTGTAGCGTGCTGATCTGTGACTCCCAGTGTTCACCACCTTCC
TGAAGACCACGCTCCCTCCCCCTGCCTCCTCCTCCTCCTCTTGGCTCTATTGGGAGCCTCAGGGCCGGCAGGGTGCTTCGGGAGCCCCCT
GCTACGGGGAAAGGCATGTGTTTCTTGCTGGTGACTCATTGCCTTCACACCACTGGGTTTGCCAGAAACAGGGAAGGAGGGCGTTAAGGG
AAAAAAAAAATCCTCAAATTTATTTACCAGTCAGCTTCTTGCTGTTCCCAGTAGAATCGCTAGCTCTTCTCCAGAGGAAAAGTACTAGGA
TTCTTAAGATGGCGAGACCCCAAGAGGGATCTCATAGCACTGCTGCATTTGCCGTTGACGCAGTCCTGACAGTGTTTGAAAAGGGCCGCC
TGCCCCCTCCCCACTGTGCTTTTGATGCCTTTGGAGTCAAAGGCAGGTGGGGTCACCTGATGAGCTAAGATCCAGCCCCAGAATCCTGGA
GGAGCAGGAGGTAGCAGGAGAGGACCAGGTCCCCAAGTCCCTTCACAGGGTCCCCACCCCCACTGGCTTTGGTGCTGTCCACACAGTGCC
CACCAGAAGGCAGAGGGAACTCCAGGGCAGGGATGTGCCTGAAAGAGTCAACAGTCCCCTGATCCCCTACCTCTGCCTGCCCTCCAGCCC
CATCACCAGCTTCTTGCTCAGGGAGACTTCCGCCCTCCTCACTGAGGCAACATGAAGCCCGAGGCCCAGATGGGGGCTGAACAGGTAGGG
CACATCAGTTAATGCCAGTGAGGTCAGCTTCTGCCCTCCAGCAATACATGTGCAGGGGTTGCTGCTTTCCCAGTGCCAGGAGAACCCCCG
CTCCGAGTCAGCCTGTGTGGGTCATGAGGCTGGGGCCCAGGAGACACGGTCCCAGGCACTGCACAGGCCTGCAGTATTACCAGGCGGAGG
GGCTGCTTTTCTGCCCTTCCTCACCCCCACGCCCCACCCCACTCCCCCAGAGTACTCCCCACTGTGAAAAGAGCTGGAAACTAAACTGGT
TAGAATGAACCTGGCTCCCTGAGCATCCCTGGATCCTTCAAATAGGCCCTGAGATGTGAGGTCTGCTGCTTCACTGGGGCCCGATGACTT
TGGCTGGGGGAGGGGGCCTAGGGCCTCTTCTCATTGAAAGCTCTGCTTTATACAGACCCAAGCATACACACCAGGCCGTCACTTTGGGTT
CTGGCATAAGTTCAGAACAATTCAAGTCCATGTGTCCCATGGCTGGTCAGAGCCCTGGGTCAAAACCACTCAGCCCAGGGGAGGGGATGA

>96556_96556_1_UCHL5-SLC6A17_UCHL5_chr1_193018875_ENST00000367449_SLC6A17_chr1_110734593_ENST00000331565_length(amino acids)=566AA_BP=127
MSGSRRGDVWLTSSAAGLLRSVAGGSWCGGQLRARGGSGRCVARAMTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEK
LKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINF
FTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDEL
DKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVT
MFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYL
YFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTS

--------------------------------------------------------------
>96556_96556_2_UCHL5-SLC6A17_UCHL5_chr1_193018875_ENST00000367451_SLC6A17_chr1_110734593_ENST00000331565_length(transcript)=5413nt_BP=335nt
CGGGTTTGCTGAGATCTGTGGCCGGCGGCAGCTGGTGCGGGGGGCAGCTGAGAGCGAGAGGTGGATCGGGGCGGTGTGTGGCCAGGGCCA
TGACGGGCAATGCCGGGGAGTGGTGCCTCATGGAAAGCGACCCCGGGGTCTTCACCGAGCTCATTAAAGGATTCGGTTGCCGAGGAGCCC
AAGTAGAAGAAATATGGAGTTTAGAGCCTGAGAATTTTGAAAAATTAAAGCCAGTTCATGGGTTAATTTTTCTTTTCAAGTGGCAGCCAG
GAGAAGAACCAGCAGGCTCTGTGGTTCAGGACTCCCGACTTGACACGATATTTTTTGCTAAGCAGCTGGACAAGATGCTGGACCCCCAGG
TGTGGCGGGAGGCAGCTACCCAGGTCTTCTTTGCCTTGGGCCTGGGCTTTGGTGGTGTCATTGCCTTCTCCAGCTACAATAAGCAGGACA
ACAACTGCCACTTCGATGCCGCCCTGGTGTCCTTCATCAACTTCTTCACGTCAGTGTTGGCCACCCTCGTGGTGTTTGCTGTGCTGGGCT
TCAAGGCCAACATCATGAATGAGAAGTGTGTGGTCGAGAATGCTGAGAAAATCCTAGGGTACCTTAACACCAACGTCCTGAGCCGGGACC
TCATCCCACCCCACGTCAACTTCTCCCACCTGACCACAAAGGACTACATGGAGATGTACAATGTCATCATGACCGTGAAGGAGGACCAGT
TCTCAGCCCTGGGCCTTGACCCCTGCCTTCTGGAGGACGAGCTGGACAAGTCCGTGCAGGGCACAGGCCTGGCCTTCATCGCCTTCACTG
AGGCCATGACGCACTTCCCCGCCTCCCCGTTCTGGTCCGTCATGTTCTTCTTGATGCTTATCAACCTGGGCCTGGGCAGCATGATCGGGA
CCATGGCAGGCATCACCACGCCCATCATCGACACCTTCAAGGTGCCCAAGGAGATGTTCACAGTGGGCTGCTGTGTCTTTGCATTCCTCG
TGGGGCTGTTGTTCGTCCAGCGCTCCGGAAACTACTTTGTCACCATGTTCGATGACTACTCGGCCACCCTGCCACTCACTCTCATCGTCA
TCCTTGAGAACATCGCTGTGGCCTGGATTTATGGAACCAAGAAGTTCATGCAGGAGCTGACGGAGATGCTGGGCTTCCGCCCCTACCGCT
TCTATTTCTACATGTGGAAGTTCGTGTCTCCACTATGCATGGCTGTGCTCACCACAGCCAGCATCATCCAGCTGGGGGTCACGCCCCCGG
GCTACAGCGCCTGGATCAAGGAGGAGGCTGCCGAGCGCTACCTGTATTTCCCCAACTGGGCCATGGCACTCCTGATCACCCTCATCGTCG
TGGCGACGCTGCCCATCCCTGTGGTGTTCGTCCTGCGGCACTTCCACCTGCTCTCTGATGGCTCCAACACCCTCTCCGTGTCCTACAAGA
AGGGCCGCATGATGAAGGACATCTCCAACCTGGAGGAGAACGATGAGACCCGCTTCATCCTCAGCAAGGTGCCCAGTGAGGCACCTTCCC
CCATGCCCACTCACCGTTCCTATCTGGGGCCCGGCAGCACATCACCCCTGGAGACCAGCGGTAACCCCAATGGACGCTATGGGAGCGGCT
ACCTGCTGGCCAGCACCCCTGAGTCGGAGCTGTGACCACTGCCCAAGCCCTGCCCGCCTCTCCCCCCACGCTCAACCTGCCCACTTGTCC
AGGCCTGGCCTCTTTCTTGAGGTGGCCACCAGGCCCAGGCCAGGCCCTTTGCCCAAGAAGAGAGGGTCTGCCCTGCCTCACTCCCCTCTT
CAGTCCCAGTAGACTCTGCTCCCTAGCCCTGAGCAGGAGGCTGGGAGCAGCTCTGTTTCCTAATTCAGGACCCCACTCATCTAGCCCTCC
AAGAGCCTCCGCCAAATTGTAGCCATGTAATTGGAACAACCCATAAGGCCTGCTTCCCAGTCCATGGGAGATTCCAAGTGGCCACTGCAG
GAGTCACTCACCTCCCTCTCTCCCTGTAACTTGCCACCTGCAGTTCTTAGGGCTGTGGGGTCAGATGGTGGTGGTGAGAGGCCTTGGGGC
TGGGGAAGGAGAGTGGACTTTGGCTCACTCTGCCATGAGAACAGGACACCATCCTGCCCAGCCCAGACGGGGTTGCTCCTGGTCCAAGAG
GCTACCTGCTCCAAGGCGGAGGGTGGGAGCAGGTGTGCCAGGGCTCAGGGCTCAGACTTGGGAGGGCCTAGGCAGAAGCCCCAAGTTCTG
TTTTCTGAGGTATGTGCTGCCCTTGGCTTCAGCATGAGCCTTGGTAGCAGAAGGTGAGGAACCTCCTCTGCCCTGGTCCCTGGGTGGAAT
CTTCCCATGTCCTTGGCCCTGCCTGGGGTGTGTGGTGTGTGCTCCTGCATCTTGTCTGGGAGTGCAGTGACCGGGACCAGAACCTTCCCC
ACCTCAATTAGGGCTTAGCCATCTCCCTGTCCCCAGCACCCCTCCCCAGCCCACAGTGGTGGCCTCTGCCTCTTTCCTGGAGAGAGAAGG
ACAGTGCACGGAGAGGTTTCCAGAGCACAAATTGTTGGTTCCTAGCACAAATTAGATGGTTTGGAGCACAATGGTGAAGCACACTCCCCT
CCCTCCTCACCTGGGGTCCAATGTTCTGTCTAGTGGCAGCTTTTCCCCTGGAACAGGGGTCCCTGGAGTTCACAGGCTTATCCCCAGGAA
GCCTCACTCCTGGGGAAAGACAGATAATTTCACTGCCCCTTTGAGCCACCACTCACTCTCCTTATTACACAAGCACAGCCGCCCAGTGTG
CACATCATGTGCAGACACCTTGGAAACCTTTCCCAAGCCTTCCTGGCCCACAGTGGCCAGTGCCATAGGCAGTGCTGTGGACAGTAGAGG
CTGCCAAAGGCAAGGGCTGGTCTTCAGGATGGAGGCCAGCCTGTGCAGAAGGCTGCAGCTGACAACAGCGACCCCACCTGCCATTACCTT
CAGGGCCTCCTCTGGAAGAGAACCCATTCTCAGAGTGCAGCCAGGGAGGAACCTGACCCAAGAGTAAATGTCTGCAGAGAGATGGATGGA
TGGATGGATAGATGGATGGATGGGTTGGGGAGTGGGGGTGGATGGATGGATAGATGGATGGATGGATGGATGGATGGGTTGGGGGGTGGG
GGTGGATGGATAGATGGATGGATGGATGGACGGATGGGGTGGGGGAAGGAAGGAAAGGAGGGAGAAAGGAGGGAATACTGGCTCCATCTT
TGAGAGCTCTGGTGGGCAGGGCAGAAACAGGCCACAGTGCTCAACCCGGACACCCTCACGAAGGGTCGCAAGTCACTCTTGTGGCTCAGA
TTGCTCTTAGGACCTGGAGGGACAGACCAGAATCAGGGTCCCCTCCTTTACCCCTGAGTTCCTTACTGTTCCCCCAAGCCTGGGAGCAGT
CTATCCCCCAACCCTGCCATCTCCCTTACTCATCCCTCTTCCACAGCTTCCCCTTTCTAGCCCCCTCTGCCCTACCTGTCTTTCCTGAGT
GTTTGAGGGGAGAGAGAGACCCACATCTCCCCAAAGAGATGAGCTTTTGGGGCACAACATCCCACCGCAGTCCCCCTCACCCGACAACAC
CTCCTACCTGGCCCCTTGCCAAATCCCAAGCAGAATTAGCAACAGGAAAAGCAGAGCCCCAGGAGAGACACTCTACTATATATACTCTTC
TATATATTCTGTTTCTATTGTATATTCACTCTGTACATGTGGGTGTAAATGCTGTTAAATGACAAACCCAATATTATACTGTGGCTGGTG
GACTATTTTCATCCTCAGTGCTGTACAGATCTATTTTCATTGTATATTTGATATATTTTTAATTTTGTAGCGTGTGGCTGGGCCAGGCCC
CAGCGGGAGGGGCTGAGCTGGGGCTGTGTGCTTGCTAGGTGTGGGCGCGCTAGTGCTCGTTGTAGCCTTTTGCTGTGTCTTCGCTGTGTG
TTAGACGTAGGGCCTAGAGCTCGGGGTGTGTGTGTGCGTGCTGTGTGTATGGTGTGCACATACGTGAGTGTGGGTGTGTGTAGCGTGCTG
ATCTGTGACTCCCAGTGTTCACCACCTTCCTGAAGACCACGCTCCCTCCCCCTGCCTCCTCCTCCTCCTCTTGGCTCTATTGGGAGCCTC
AGGGCCGGCAGGGTGCTTCGGGAGCCCCCTGCTACGGGGAAAGGCATGTGTTTCTTGCTGGTGACTCATTGCCTTCACACCACTGGGTTT
GCCAGAAACAGGGAAGGAGGGCGTTAAGGGAAAAAAAAAATCCTCAAATTTATTTACCAGTCAGCTTCTTGCTGTTCCCAGTAGAATCGC
TAGCTCTTCTCCAGAGGAAAAGTACTAGGATTCTTAAGATGGCGAGACCCCAAGAGGGATCTCATAGCACTGCTGCATTTGCCGTTGACG
CAGTCCTGACAGTGTTTGAAAAGGGCCGCCTGCCCCCTCCCCACTGTGCTTTTGATGCCTTTGGAGTCAAAGGCAGGTGGGGTCACCTGA
TGAGCTAAGATCCAGCCCCAGAATCCTGGAGGAGCAGGAGGTAGCAGGAGAGGACCAGGTCCCCAAGTCCCTTCACAGGGTCCCCACCCC
CACTGGCTTTGGTGCTGTCCACACAGTGCCCACCAGAAGGCAGAGGGAACTCCAGGGCAGGGATGTGCCTGAAAGAGTCAACAGTCCCCT
GATCCCCTACCTCTGCCTGCCCTCCAGCCCCATCACCAGCTTCTTGCTCAGGGAGACTTCCGCCCTCCTCACTGAGGCAACATGAAGCCC
GAGGCCCAGATGGGGGCTGAACAGGTAGGGCACATCAGTTAATGCCAGTGAGGTCAGCTTCTGCCCTCCAGCAATACATGTGCAGGGGTT
GCTGCTTTCCCAGTGCCAGGAGAACCCCCGCTCCGAGTCAGCCTGTGTGGGTCATGAGGCTGGGGCCCAGGAGACACGGTCCCAGGCACT
GCACAGGCCTGCAGTATTACCAGGCGGAGGGGCTGCTTTTCTGCCCTTCCTCACCCCCACGCCCCACCCCACTCCCCCAGAGTACTCCCC
ACTGTGAAAAGAGCTGGAAACTAAACTGGTTAGAATGAACCTGGCTCCCTGAGCATCCCTGGATCCTTCAAATAGGCCCTGAGATGTGAG
GTCTGCTGCTTCACTGGGGCCCGATGACTTTGGCTGGGGGAGGGGGCCTAGGGCCTCTTCTCATTGAAAGCTCTGCTTTATACAGACCCA
AGCATACACACCAGGCCGTCACTTTGGGTTCTGGCATAAGTTCAGAACAATTCAAGTCCATGTGTCCCATGGCTGGTCAGAGCCCTGGGT
CAAAACCACTCAGCCCAGGGGAGGGGATGAGGCATTGTCACCCTAGACCCCTCTTCCTCTCTCCCCCACCATAGTGTGCAATAAAGTGTC

>96556_96556_2_UCHL5-SLC6A17_UCHL5_chr1_193018875_ENST00000367451_SLC6A17_chr1_110734593_ENST00000331565_length(amino acids)=549AA_BP=110
MLRSVAGGSWCGGQLRARGGSGRCVARAMTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGE
EPAGSVVQDSRLDTIFFAKQLDKMLDPQVWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFK
ANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEA
MTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVIL
ENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVA
TLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRMMKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLETSGNPNGRYGSGYL

--------------------------------------------------------------
>96556_96556_3_UCHL5-SLC6A17_UCHL5_chr1_193018875_ENST00000367454_SLC6A17_chr1_110734593_ENST00000331565_length(transcript)=5560nt_BP=482nt
CGCTACGGGTGCTGCAAGGCCTGGGAAGAGTTTCGATGTCTCTAGGGTGGCTAGAGCGTCCTCCCGCGCTCAGTCGCGCTGCAGGTGACG
GCGCCCGGAGGCTGTCGGGAAGTAGGCGGGGTGACGTGTGGTTGACGAGCTCGGCGGCGGGTTTGCTGAGATCTGTGGCCGGCGGCAGCT
GGTGCGGGGGGCAGCTGAGAGCGAGAGGTGGATCGGGGCGGTGTGTGGCCAGGGCCATGACGGGCAATGCCGGGGAGTGGTGCCTCATGG
AAAGCGACCCCGGGGTCTTCACCGAGCTCATTAAAGGATTCGGTTGCCGAGGAGCCCAAGTAGAAGAAATATGGAGTTTAGAGCCTGAGA
ATTTTGAAAAATTAAAGCCAGTTCATGGGTTAATTTTTCTTTTCAAGTGGCAGCCAGGAGAAGAACCAGCAGGCTCTGTGGTTCAGGACT
CCCGACTTGACACGATATTTTTTGCTAAGCAGCTGGACAAGATGCTGGACCCCCAGGTGTGGCGGGAGGCAGCTACCCAGGTCTTCTTTG
CCTTGGGCCTGGGCTTTGGTGGTGTCATTGCCTTCTCCAGCTACAATAAGCAGGACAACAACTGCCACTTCGATGCCGCCCTGGTGTCCT
TCATCAACTTCTTCACGTCAGTGTTGGCCACCCTCGTGGTGTTTGCTGTGCTGGGCTTCAAGGCCAACATCATGAATGAGAAGTGTGTGG
TCGAGAATGCTGAGAAAATCCTAGGGTACCTTAACACCAACGTCCTGAGCCGGGACCTCATCCCACCCCACGTCAACTTCTCCCACCTGA
CCACAAAGGACTACATGGAGATGTACAATGTCATCATGACCGTGAAGGAGGACCAGTTCTCAGCCCTGGGCCTTGACCCCTGCCTTCTGG
AGGACGAGCTGGACAAGTCCGTGCAGGGCACAGGCCTGGCCTTCATCGCCTTCACTGAGGCCATGACGCACTTCCCCGCCTCCCCGTTCT
GGTCCGTCATGTTCTTCTTGATGCTTATCAACCTGGGCCTGGGCAGCATGATCGGGACCATGGCAGGCATCACCACGCCCATCATCGACA
CCTTCAAGGTGCCCAAGGAGATGTTCACAGTGGGCTGCTGTGTCTTTGCATTCCTCGTGGGGCTGTTGTTCGTCCAGCGCTCCGGAAACT
ACTTTGTCACCATGTTCGATGACTACTCGGCCACCCTGCCACTCACTCTCATCGTCATCCTTGAGAACATCGCTGTGGCCTGGATTTATG
GAACCAAGAAGTTCATGCAGGAGCTGACGGAGATGCTGGGCTTCCGCCCCTACCGCTTCTATTTCTACATGTGGAAGTTCGTGTCTCCAC
TATGCATGGCTGTGCTCACCACAGCCAGCATCATCCAGCTGGGGGTCACGCCCCCGGGCTACAGCGCCTGGATCAAGGAGGAGGCTGCCG
AGCGCTACCTGTATTTCCCCAACTGGGCCATGGCACTCCTGATCACCCTCATCGTCGTGGCGACGCTGCCCATCCCTGTGGTGTTCGTCC
TGCGGCACTTCCACCTGCTCTCTGATGGCTCCAACACCCTCTCCGTGTCCTACAAGAAGGGCCGCATGATGAAGGACATCTCCAACCTGG
AGGAGAACGATGAGACCCGCTTCATCCTCAGCAAGGTGCCCAGTGAGGCACCTTCCCCCATGCCCACTCACCGTTCCTATCTGGGGCCCG
GCAGCACATCACCCCTGGAGACCAGCGGTAACCCCAATGGACGCTATGGGAGCGGCTACCTGCTGGCCAGCACCCCTGAGTCGGAGCTGT
GACCACTGCCCAAGCCCTGCCCGCCTCTCCCCCCACGCTCAACCTGCCCACTTGTCCAGGCCTGGCCTCTTTCTTGAGGTGGCCACCAGG
CCCAGGCCAGGCCCTTTGCCCAAGAAGAGAGGGTCTGCCCTGCCTCACTCCCCTCTTCAGTCCCAGTAGACTCTGCTCCCTAGCCCTGAG
CAGGAGGCTGGGAGCAGCTCTGTTTCCTAATTCAGGACCCCACTCATCTAGCCCTCCAAGAGCCTCCGCCAAATTGTAGCCATGTAATTG
GAACAACCCATAAGGCCTGCTTCCCAGTCCATGGGAGATTCCAAGTGGCCACTGCAGGAGTCACTCACCTCCCTCTCTCCCTGTAACTTG
CCACCTGCAGTTCTTAGGGCTGTGGGGTCAGATGGTGGTGGTGAGAGGCCTTGGGGCTGGGGAAGGAGAGTGGACTTTGGCTCACTCTGC
CATGAGAACAGGACACCATCCTGCCCAGCCCAGACGGGGTTGCTCCTGGTCCAAGAGGCTACCTGCTCCAAGGCGGAGGGTGGGAGCAGG
TGTGCCAGGGCTCAGGGCTCAGACTTGGGAGGGCCTAGGCAGAAGCCCCAAGTTCTGTTTTCTGAGGTATGTGCTGCCCTTGGCTTCAGC
ATGAGCCTTGGTAGCAGAAGGTGAGGAACCTCCTCTGCCCTGGTCCCTGGGTGGAATCTTCCCATGTCCTTGGCCCTGCCTGGGGTGTGT
GGTGTGTGCTCCTGCATCTTGTCTGGGAGTGCAGTGACCGGGACCAGAACCTTCCCCACCTCAATTAGGGCTTAGCCATCTCCCTGTCCC
CAGCACCCCTCCCCAGCCCACAGTGGTGGCCTCTGCCTCTTTCCTGGAGAGAGAAGGACAGTGCACGGAGAGGTTTCCAGAGCACAAATT
GTTGGTTCCTAGCACAAATTAGATGGTTTGGAGCACAATGGTGAAGCACACTCCCCTCCCTCCTCACCTGGGGTCCAATGTTCTGTCTAG
TGGCAGCTTTTCCCCTGGAACAGGGGTCCCTGGAGTTCACAGGCTTATCCCCAGGAAGCCTCACTCCTGGGGAAAGACAGATAATTTCAC
TGCCCCTTTGAGCCACCACTCACTCTCCTTATTACACAAGCACAGCCGCCCAGTGTGCACATCATGTGCAGACACCTTGGAAACCTTTCC
CAAGCCTTCCTGGCCCACAGTGGCCAGTGCCATAGGCAGTGCTGTGGACAGTAGAGGCTGCCAAAGGCAAGGGCTGGTCTTCAGGATGGA
GGCCAGCCTGTGCAGAAGGCTGCAGCTGACAACAGCGACCCCACCTGCCATTACCTTCAGGGCCTCCTCTGGAAGAGAACCCATTCTCAG
AGTGCAGCCAGGGAGGAACCTGACCCAAGAGTAAATGTCTGCAGAGAGATGGATGGATGGATGGATAGATGGATGGATGGGTTGGGGAGT
GGGGGTGGATGGATGGATAGATGGATGGATGGATGGATGGATGGGTTGGGGGGTGGGGGTGGATGGATAGATGGATGGATGGATGGACGG
ATGGGGTGGGGGAAGGAAGGAAAGGAGGGAGAAAGGAGGGAATACTGGCTCCATCTTTGAGAGCTCTGGTGGGCAGGGCAGAAACAGGCC
ACAGTGCTCAACCCGGACACCCTCACGAAGGGTCGCAAGTCACTCTTGTGGCTCAGATTGCTCTTAGGACCTGGAGGGACAGACCAGAAT
CAGGGTCCCCTCCTTTACCCCTGAGTTCCTTACTGTTCCCCCAAGCCTGGGAGCAGTCTATCCCCCAACCCTGCCATCTCCCTTACTCAT
CCCTCTTCCACAGCTTCCCCTTTCTAGCCCCCTCTGCCCTACCTGTCTTTCCTGAGTGTTTGAGGGGAGAGAGAGACCCACATCTCCCCA
AAGAGATGAGCTTTTGGGGCACAACATCCCACCGCAGTCCCCCTCACCCGACAACACCTCCTACCTGGCCCCTTGCCAAATCCCAAGCAG
AATTAGCAACAGGAAAAGCAGAGCCCCAGGAGAGACACTCTACTATATATACTCTTCTATATATTCTGTTTCTATTGTATATTCACTCTG
TACATGTGGGTGTAAATGCTGTTAAATGACAAACCCAATATTATACTGTGGCTGGTGGACTATTTTCATCCTCAGTGCTGTACAGATCTA
TTTTCATTGTATATTTGATATATTTTTAATTTTGTAGCGTGTGGCTGGGCCAGGCCCCAGCGGGAGGGGCTGAGCTGGGGCTGTGTGCTT
GCTAGGTGTGGGCGCGCTAGTGCTCGTTGTAGCCTTTTGCTGTGTCTTCGCTGTGTGTTAGACGTAGGGCCTAGAGCTCGGGGTGTGTGT
GTGCGTGCTGTGTGTATGGTGTGCACATACGTGAGTGTGGGTGTGTGTAGCGTGCTGATCTGTGACTCCCAGTGTTCACCACCTTCCTGA
AGACCACGCTCCCTCCCCCTGCCTCCTCCTCCTCCTCTTGGCTCTATTGGGAGCCTCAGGGCCGGCAGGGTGCTTCGGGAGCCCCCTGCT
ACGGGGAAAGGCATGTGTTTCTTGCTGGTGACTCATTGCCTTCACACCACTGGGTTTGCCAGAAACAGGGAAGGAGGGCGTTAAGGGAAA
AAAAAAATCCTCAAATTTATTTACCAGTCAGCTTCTTGCTGTTCCCAGTAGAATCGCTAGCTCTTCTCCAGAGGAAAAGTACTAGGATTC
TTAAGATGGCGAGACCCCAAGAGGGATCTCATAGCACTGCTGCATTTGCCGTTGACGCAGTCCTGACAGTGTTTGAAAAGGGCCGCCTGC
CCCCTCCCCACTGTGCTTTTGATGCCTTTGGAGTCAAAGGCAGGTGGGGTCACCTGATGAGCTAAGATCCAGCCCCAGAATCCTGGAGGA
GCAGGAGGTAGCAGGAGAGGACCAGGTCCCCAAGTCCCTTCACAGGGTCCCCACCCCCACTGGCTTTGGTGCTGTCCACACAGTGCCCAC
CAGAAGGCAGAGGGAACTCCAGGGCAGGGATGTGCCTGAAAGAGTCAACAGTCCCCTGATCCCCTACCTCTGCCTGCCCTCCAGCCCCAT
CACCAGCTTCTTGCTCAGGGAGACTTCCGCCCTCCTCACTGAGGCAACATGAAGCCCGAGGCCCAGATGGGGGCTGAACAGGTAGGGCAC
ATCAGTTAATGCCAGTGAGGTCAGCTTCTGCCCTCCAGCAATACATGTGCAGGGGTTGCTGCTTTCCCAGTGCCAGGAGAACCCCCGCTC
CGAGTCAGCCTGTGTGGGTCATGAGGCTGGGGCCCAGGAGACACGGTCCCAGGCACTGCACAGGCCTGCAGTATTACCAGGCGGAGGGGC
TGCTTTTCTGCCCTTCCTCACCCCCACGCCCCACCCCACTCCCCCAGAGTACTCCCCACTGTGAAAAGAGCTGGAAACTAAACTGGTTAG
AATGAACCTGGCTCCCTGAGCATCCCTGGATCCTTCAAATAGGCCCTGAGATGTGAGGTCTGCTGCTTCACTGGGGCCCGATGACTTTGG
CTGGGGGAGGGGGCCTAGGGCCTCTTCTCATTGAAAGCTCTGCTTTATACAGACCCAAGCATACACACCAGGCCGTCACTTTGGGTTCTG
GCATAAGTTCAGAACAATTCAAGTCCATGTGTCCCATGGCTGGTCAGAGCCCTGGGTCAAAACCACTCAGCCCAGGGGAGGGGATGAGGC

>96556_96556_3_UCHL5-SLC6A17_UCHL5_chr1_193018875_ENST00000367454_SLC6A17_chr1_110734593_ENST00000331565_length(amino acids)=596AA_BP=157
MQGLGRVSMSLGWLERPPALSRAAGDGARRLSGSRRGDVWLTSSAAGLLRSVAGGSWCGGQLRARGGSGRCVARAMTGNAGEWCLMESDP
GVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQLDKMLDPQVWREAATQVFFALGL
GFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKD
YMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKV
PKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMA
VLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRMMKDISNLEEND

--------------------------------------------------------------
>96556_96556_4_UCHL5-SLC6A17_UCHL5_chr1_193018875_ENST00000367455_SLC6A17_chr1_110734593_ENST00000331565_length(transcript)=5560nt_BP=482nt
CGCTACGGGTGCTGCAAGGCCTGGGAAGAGTTTCGATGTCTCTAGGGTGGCTAGAGCGTCCTCCCGCGCTCAGTCGCGCTGCAGGTGACG
GCGCCCGGAGGCTGTCGGGAAGTAGGCGGGGTGACGTGTGGTTGACGAGCTCGGCGGCGGGTTTGCTGAGATCTGTGGCCGGCGGCAGCT
GGTGCGGGGGGCAGCTGAGAGCGAGAGGTGGATCGGGGCGGTGTGTGGCCAGGGCCATGACGGGCAATGCCGGGGAGTGGTGCCTCATGG
AAAGCGACCCCGGGGTCTTCACCGAGCTCATTAAAGGATTCGGTTGCCGAGGAGCCCAAGTAGAAGAAATATGGAGTTTAGAGCCTGAGA
ATTTTGAAAAATTAAAGCCAGTTCATGGGTTAATTTTTCTTTTCAAGTGGCAGCCAGGAGAAGAACCAGCAGGCTCTGTGGTTCAGGACT
CCCGACTTGACACGATATTTTTTGCTAAGCAGCTGGACAAGATGCTGGACCCCCAGGTGTGGCGGGAGGCAGCTACCCAGGTCTTCTTTG
CCTTGGGCCTGGGCTTTGGTGGTGTCATTGCCTTCTCCAGCTACAATAAGCAGGACAACAACTGCCACTTCGATGCCGCCCTGGTGTCCT
TCATCAACTTCTTCACGTCAGTGTTGGCCACCCTCGTGGTGTTTGCTGTGCTGGGCTTCAAGGCCAACATCATGAATGAGAAGTGTGTGG
TCGAGAATGCTGAGAAAATCCTAGGGTACCTTAACACCAACGTCCTGAGCCGGGACCTCATCCCACCCCACGTCAACTTCTCCCACCTGA
CCACAAAGGACTACATGGAGATGTACAATGTCATCATGACCGTGAAGGAGGACCAGTTCTCAGCCCTGGGCCTTGACCCCTGCCTTCTGG
AGGACGAGCTGGACAAGTCCGTGCAGGGCACAGGCCTGGCCTTCATCGCCTTCACTGAGGCCATGACGCACTTCCCCGCCTCCCCGTTCT
GGTCCGTCATGTTCTTCTTGATGCTTATCAACCTGGGCCTGGGCAGCATGATCGGGACCATGGCAGGCATCACCACGCCCATCATCGACA
CCTTCAAGGTGCCCAAGGAGATGTTCACAGTGGGCTGCTGTGTCTTTGCATTCCTCGTGGGGCTGTTGTTCGTCCAGCGCTCCGGAAACT
ACTTTGTCACCATGTTCGATGACTACTCGGCCACCCTGCCACTCACTCTCATCGTCATCCTTGAGAACATCGCTGTGGCCTGGATTTATG
GAACCAAGAAGTTCATGCAGGAGCTGACGGAGATGCTGGGCTTCCGCCCCTACCGCTTCTATTTCTACATGTGGAAGTTCGTGTCTCCAC
TATGCATGGCTGTGCTCACCACAGCCAGCATCATCCAGCTGGGGGTCACGCCCCCGGGCTACAGCGCCTGGATCAAGGAGGAGGCTGCCG
AGCGCTACCTGTATTTCCCCAACTGGGCCATGGCACTCCTGATCACCCTCATCGTCGTGGCGACGCTGCCCATCCCTGTGGTGTTCGTCC
TGCGGCACTTCCACCTGCTCTCTGATGGCTCCAACACCCTCTCCGTGTCCTACAAGAAGGGCCGCATGATGAAGGACATCTCCAACCTGG
AGGAGAACGATGAGACCCGCTTCATCCTCAGCAAGGTGCCCAGTGAGGCACCTTCCCCCATGCCCACTCACCGTTCCTATCTGGGGCCCG
GCAGCACATCACCCCTGGAGACCAGCGGTAACCCCAATGGACGCTATGGGAGCGGCTACCTGCTGGCCAGCACCCCTGAGTCGGAGCTGT
GACCACTGCCCAAGCCCTGCCCGCCTCTCCCCCCACGCTCAACCTGCCCACTTGTCCAGGCCTGGCCTCTTTCTTGAGGTGGCCACCAGG
CCCAGGCCAGGCCCTTTGCCCAAGAAGAGAGGGTCTGCCCTGCCTCACTCCCCTCTTCAGTCCCAGTAGACTCTGCTCCCTAGCCCTGAG
CAGGAGGCTGGGAGCAGCTCTGTTTCCTAATTCAGGACCCCACTCATCTAGCCCTCCAAGAGCCTCCGCCAAATTGTAGCCATGTAATTG
GAACAACCCATAAGGCCTGCTTCCCAGTCCATGGGAGATTCCAAGTGGCCACTGCAGGAGTCACTCACCTCCCTCTCTCCCTGTAACTTG
CCACCTGCAGTTCTTAGGGCTGTGGGGTCAGATGGTGGTGGTGAGAGGCCTTGGGGCTGGGGAAGGAGAGTGGACTTTGGCTCACTCTGC
CATGAGAACAGGACACCATCCTGCCCAGCCCAGACGGGGTTGCTCCTGGTCCAAGAGGCTACCTGCTCCAAGGCGGAGGGTGGGAGCAGG
TGTGCCAGGGCTCAGGGCTCAGACTTGGGAGGGCCTAGGCAGAAGCCCCAAGTTCTGTTTTCTGAGGTATGTGCTGCCCTTGGCTTCAGC
ATGAGCCTTGGTAGCAGAAGGTGAGGAACCTCCTCTGCCCTGGTCCCTGGGTGGAATCTTCCCATGTCCTTGGCCCTGCCTGGGGTGTGT
GGTGTGTGCTCCTGCATCTTGTCTGGGAGTGCAGTGACCGGGACCAGAACCTTCCCCACCTCAATTAGGGCTTAGCCATCTCCCTGTCCC
CAGCACCCCTCCCCAGCCCACAGTGGTGGCCTCTGCCTCTTTCCTGGAGAGAGAAGGACAGTGCACGGAGAGGTTTCCAGAGCACAAATT
GTTGGTTCCTAGCACAAATTAGATGGTTTGGAGCACAATGGTGAAGCACACTCCCCTCCCTCCTCACCTGGGGTCCAATGTTCTGTCTAG
TGGCAGCTTTTCCCCTGGAACAGGGGTCCCTGGAGTTCACAGGCTTATCCCCAGGAAGCCTCACTCCTGGGGAAAGACAGATAATTTCAC
TGCCCCTTTGAGCCACCACTCACTCTCCTTATTACACAAGCACAGCCGCCCAGTGTGCACATCATGTGCAGACACCTTGGAAACCTTTCC
CAAGCCTTCCTGGCCCACAGTGGCCAGTGCCATAGGCAGTGCTGTGGACAGTAGAGGCTGCCAAAGGCAAGGGCTGGTCTTCAGGATGGA
GGCCAGCCTGTGCAGAAGGCTGCAGCTGACAACAGCGACCCCACCTGCCATTACCTTCAGGGCCTCCTCTGGAAGAGAACCCATTCTCAG
AGTGCAGCCAGGGAGGAACCTGACCCAAGAGTAAATGTCTGCAGAGAGATGGATGGATGGATGGATAGATGGATGGATGGGTTGGGGAGT
GGGGGTGGATGGATGGATAGATGGATGGATGGATGGATGGATGGGTTGGGGGGTGGGGGTGGATGGATAGATGGATGGATGGATGGACGG
ATGGGGTGGGGGAAGGAAGGAAAGGAGGGAGAAAGGAGGGAATACTGGCTCCATCTTTGAGAGCTCTGGTGGGCAGGGCAGAAACAGGCC
ACAGTGCTCAACCCGGACACCCTCACGAAGGGTCGCAAGTCACTCTTGTGGCTCAGATTGCTCTTAGGACCTGGAGGGACAGACCAGAAT
CAGGGTCCCCTCCTTTACCCCTGAGTTCCTTACTGTTCCCCCAAGCCTGGGAGCAGTCTATCCCCCAACCCTGCCATCTCCCTTACTCAT
CCCTCTTCCACAGCTTCCCCTTTCTAGCCCCCTCTGCCCTACCTGTCTTTCCTGAGTGTTTGAGGGGAGAGAGAGACCCACATCTCCCCA
AAGAGATGAGCTTTTGGGGCACAACATCCCACCGCAGTCCCCCTCACCCGACAACACCTCCTACCTGGCCCCTTGCCAAATCCCAAGCAG
AATTAGCAACAGGAAAAGCAGAGCCCCAGGAGAGACACTCTACTATATATACTCTTCTATATATTCTGTTTCTATTGTATATTCACTCTG
TACATGTGGGTGTAAATGCTGTTAAATGACAAACCCAATATTATACTGTGGCTGGTGGACTATTTTCATCCTCAGTGCTGTACAGATCTA
TTTTCATTGTATATTTGATATATTTTTAATTTTGTAGCGTGTGGCTGGGCCAGGCCCCAGCGGGAGGGGCTGAGCTGGGGCTGTGTGCTT
GCTAGGTGTGGGCGCGCTAGTGCTCGTTGTAGCCTTTTGCTGTGTCTTCGCTGTGTGTTAGACGTAGGGCCTAGAGCTCGGGGTGTGTGT
GTGCGTGCTGTGTGTATGGTGTGCACATACGTGAGTGTGGGTGTGTGTAGCGTGCTGATCTGTGACTCCCAGTGTTCACCACCTTCCTGA
AGACCACGCTCCCTCCCCCTGCCTCCTCCTCCTCCTCTTGGCTCTATTGGGAGCCTCAGGGCCGGCAGGGTGCTTCGGGAGCCCCCTGCT
ACGGGGAAAGGCATGTGTTTCTTGCTGGTGACTCATTGCCTTCACACCACTGGGTTTGCCAGAAACAGGGAAGGAGGGCGTTAAGGGAAA
AAAAAAATCCTCAAATTTATTTACCAGTCAGCTTCTTGCTGTTCCCAGTAGAATCGCTAGCTCTTCTCCAGAGGAAAAGTACTAGGATTC
TTAAGATGGCGAGACCCCAAGAGGGATCTCATAGCACTGCTGCATTTGCCGTTGACGCAGTCCTGACAGTGTTTGAAAAGGGCCGCCTGC
CCCCTCCCCACTGTGCTTTTGATGCCTTTGGAGTCAAAGGCAGGTGGGGTCACCTGATGAGCTAAGATCCAGCCCCAGAATCCTGGAGGA
GCAGGAGGTAGCAGGAGAGGACCAGGTCCCCAAGTCCCTTCACAGGGTCCCCACCCCCACTGGCTTTGGTGCTGTCCACACAGTGCCCAC
CAGAAGGCAGAGGGAACTCCAGGGCAGGGATGTGCCTGAAAGAGTCAACAGTCCCCTGATCCCCTACCTCTGCCTGCCCTCCAGCCCCAT
CACCAGCTTCTTGCTCAGGGAGACTTCCGCCCTCCTCACTGAGGCAACATGAAGCCCGAGGCCCAGATGGGGGCTGAACAGGTAGGGCAC
ATCAGTTAATGCCAGTGAGGTCAGCTTCTGCCCTCCAGCAATACATGTGCAGGGGTTGCTGCTTTCCCAGTGCCAGGAGAACCCCCGCTC
CGAGTCAGCCTGTGTGGGTCATGAGGCTGGGGCCCAGGAGACACGGTCCCAGGCACTGCACAGGCCTGCAGTATTACCAGGCGGAGGGGC
TGCTTTTCTGCCCTTCCTCACCCCCACGCCCCACCCCACTCCCCCAGAGTACTCCCCACTGTGAAAAGAGCTGGAAACTAAACTGGTTAG
AATGAACCTGGCTCCCTGAGCATCCCTGGATCCTTCAAATAGGCCCTGAGATGTGAGGTCTGCTGCTTCACTGGGGCCCGATGACTTTGG
CTGGGGGAGGGGGCCTAGGGCCTCTTCTCATTGAAAGCTCTGCTTTATACAGACCCAAGCATACACACCAGGCCGTCACTTTGGGTTCTG
GCATAAGTTCAGAACAATTCAAGTCCATGTGTCCCATGGCTGGTCAGAGCCCTGGGTCAAAACCACTCAGCCCAGGGGAGGGGATGAGGC

>96556_96556_4_UCHL5-SLC6A17_UCHL5_chr1_193018875_ENST00000367455_SLC6A17_chr1_110734593_ENST00000331565_length(amino acids)=596AA_BP=157
MQGLGRVSMSLGWLERPPALSRAAGDGARRLSGSRRGDVWLTSSAAGLLRSVAGGSWCGGQLRARGGSGRCVARAMTGNAGEWCLMESDP
GVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQLDKMLDPQVWREAATQVFFALGL
GFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKD
YMEMYNVIMTVKEDQFSALGLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAGITTPIIDTFKV
PKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILENIAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMA
VLTTASIIQLGVTPPGYSAWIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRMMKDISNLEEND

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Fusion Gene PPI Analysis for UCHL5-SLC6A17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneUCHL5chr1:193018875chr1:110734593ENST00000367448-312313_32982.0410.3333333333333ADRM1
HgeneUCHL5chr1:193018875chr1:110734593ENST00000367449-311313_32982.0317.0ADRM1
HgeneUCHL5chr1:193018875chr1:110734593ENST00000367454-311313_32982.0329.0ADRM1
HgeneUCHL5chr1:193018875chr1:110734593ENST00000367455-311313_32982.0330.0ADRM1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UCHL5-SLC6A17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UCHL5-SLC6A17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource