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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UCK2-USP10 (FusionGDB2 ID:96575)

Fusion Gene Summary for UCK2-USP10

Fusion gene summary

Fusion gene information	Fusion gene name: UCK2-USP10
	Fusion gene ID: 96575
		Hgene	Tgene
	Gene symbol	UCK2	USP10
	Gene ID	7371	84669
	Gene name	uridine-cytidine kinase 2	ubiquitin specific peptidase 32
	Synonyms	TSA903\|UK\|UMPK	NY-REN-60\|USP10
	Cytomap	1q24.1	17q23.1-q23.2
	Type of gene	protein-coding	protein-coding
	Description	uridine-cytidine kinase 2cytidine monophosphokinase 2testis-specific protein TSA903uridine kinaseuridine monophosphate kinaseuridine monophosphokinase 2	ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000367879, ENST00000372212, ENST00000462329, ENST00000469256, ENST00000470820,	ENST00000562743, ENST00000219473, ENST00000570191,
Fusion gene scores	* DoF score	17 X 9 X 9=1377	17 X 15 X 9=2295
	# samples	20	19
	** MAII score	log2(20/1377*10)=-2.78345665436024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2295*10)=-3.59442282997022 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UCK2 [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UCK2(165797169)-USP10(84767041), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across UCK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across USP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AC-A6IW-01A	UCK2	chr1	165797169	+	USP10	chr16	84767041	+

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Fusion Gene ORF analysis for UCK2-USP10

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000367879	ENST00000562743	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
5CDS-3UTR	ENST00000372212	ENST00000562743	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
In-frame	ENST00000367879	ENST00000219473	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
In-frame	ENST00000367879	ENST00000570191	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
In-frame	ENST00000372212	ENST00000219473	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
In-frame	ENST00000372212	ENST00000570191	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
intron-3CDS	ENST00000462329	ENST00000219473	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
intron-3CDS	ENST00000462329	ENST00000570191	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
intron-3CDS	ENST00000469256	ENST00000219473	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
intron-3CDS	ENST00000469256	ENST00000570191	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
intron-3CDS	ENST00000470820	ENST00000219473	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
intron-3CDS	ENST00000470820	ENST00000570191	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
intron-3UTR	ENST00000462329	ENST00000562743	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
intron-3UTR	ENST00000469256	ENST00000562743	UCK2	chr1	165797169	+	USP10	chr16	84767041	+
intron-3UTR	ENST00000470820	ENST00000562743	UCK2	chr1	165797169	+	USP10	chr16	84767041	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000367879

UCK2

chr1

165797169

ENST00000219473

USP10

chr16

84767041

3277

402

120

2777

885

ENST00000367879

UCK2

chr1

165797169

ENST00000570191

USP10

chr16

84767041

2890

402

120

2777

885

ENST00000372212

UCK2

chr1

165797169

ENST00000219473

USP10

chr16

84767041

2986

111

2486

824

ENST00000372212

UCK2

chr1

165797169

ENST00000570191

USP10

chr16

84767041

2599

111

2486

824

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367879	ENST00000219473	UCK2	chr1	165797169	+	USP10	chr16	84767041	+	0.00176197	0.99823797
ENST00000367879	ENST00000570191	UCK2	chr1	165797169	+	USP10	chr16	84767041	+	0.002833831	0.9971662
ENST00000372212	ENST00000219473	UCK2	chr1	165797169	+	USP10	chr16	84767041	+	0.001267488	0.9987325
ENST00000372212	ENST00000570191	UCK2	chr1	165797169	+	USP10	chr16	84767041	+	0.002047145	0.9979528

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Fusion Genomic Features for UCK2-USP10

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
UCK2	chr1	165797169	+	USP10	chr16	84767040	+	7.86E-08	0.9999999
UCK2	chr1	165797169	+	USP10	chr16	84767040	+	7.86E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UCK2-USP10

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:165797169/chr16:84767041)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UCK2

chr1:165797169

chr16:84767041

ENST00000367879

27_35

262.0

Nucleotide binding

Note=ATP

Tgene

USP10

chr1:165797169

chr16:84767041

ENST00000219473

415_795

799.0

Domain

Note=USP

Tgene

USP10

chr1:165797169

chr16:84767041

ENST00000570191

415_795

803.0

Domain

Note=USP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for UCK2-USP10

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>96575_96575_1_UCK2-USP10_UCK2_chr1_165797169_ENST00000367879_USP10_chr16_84767041_ENST00000219473_length(transcript)=3277nt_BP=402nt
CTCGCCGCCTCCGCCTCGGCGAATAGCAGCGCGCTGCCCGCCCGGATTGGAGCAGCAGCATCACGCTGACCTCTGCCTGGGATGTAAACC
GGACCAGCCGCTGCGGGCAAAGGAAGGCTCTTGGCTCCTTCGGGAAACCCAGCCCCGTCACCGGGCTCCGAGCGGCTCGCAGGCGAGCGA
CAGCGGCCTCAGCCCCGGCAGCGCCCAGCGGCGGCTGCGGAAAGCGGAGGGAGTCCGACGCGGGCGCGGGCGGGGAGCGTGCGTCCGTTC
GCACAGGCAGCGGGAGGAGGGGCGGCGCGAACCATGGCCGGGGACAGCGAGCAGACCCTGCAGAACCACCAGCAGCCCAACGGCGGCGAG
CCCTTCCTTATAGGCGTCAGCGGGGGAACAGCTAGCGGCAAGTATATTTTTGGAGATTTTAGCCCTGATGAATTCAATCAATTCTTTGTG
ACTCCTCGATCTTCAGTTGAGCTTCCTCCATACAGTGGAACAGTTCTGTGTGGCACACAGGCTGTGGATAAACTACCTGATGGACAAGAA
TATCAGAGAATTGAGTTTGGTGTCGATGAAGTCATTGAACCCAGTGACACTTTGCCGAGAACCCCCAGCTACAGTATTTCAAGCACACTG
AACCCTCAGGCCCCTGAATTTATTCTCGGTTGTACAGCTTCCAAAATAACCCCTGATGGTATCACTAAAGAAGCAAGCTATGGCTCCATC
GACTGCCAGTACCCAGGCTCTGCCCTCGCTTTGGATGGAAGTTCTAATGTGGAGGCGGAAGTTTTGGAAAATGATGGTGTCTCAGGTGGT
CTTGGACAAAGGGAGCGTAAAAAGAAGAAAAAGCGGCCACCTGGATATTACAGCTATTTGAAAGATGGTGGCGATGATAGTATCTCCACA
GAAGCCCTGGTCAATGGCCATGCCAATTCAGCAGTCCCGAACAGTGTCAGTGCAGAGGATGCAGAATTTATGGGTGACATGCCCCCGTCA
GTTACGCCCAGGACTTGTAACAGCCCCCAGAACTCCACAGACTCTGTCAGTGACATTGTGCCTGACAGTCCTTTCCCCGGAGCACTCGGC
AGTGACACCAGGACTGCAGGGCAGCCAGAGGGGGGCCCCGGGGCTGATTTTGGTCAGTCCTGCTTCCCTGCAGAGGCTGGCAGAGACACC
CTGTCAAGGACAGCTGGGGCTCAGCCCTGCGTTGGTACCGATACTACTGAAAACCTTGGAGTTGCTAATGGACAAATACTTGAATCCTCG
GGTGAGGGCACAGCTACCAACGGGGTGGAGTTGCACACCACGGAAAGCATAGACTTGGACCCAACCAAACCCGAGAGTGCATCACCTCCT
GCTGACGGCACGGGCTCTGCATCAGGCACCCTTCCTGTCAGCCAGCCCAAGTCCTGGGCCAGCCTCTTTCATGATTCTAAGCCCTCTTCC
TCCTCGCCGGTGGCCTATGTGGAAACTAAGTATTCCCCTCCCGCCATATCTCCCCTGGTTTCTGAAAAGCAGGTTGAAGTCAAAGAAGGG
CTTGTTCCGGTTTCAGAGGATCCTGTAGCCATAAAGATTGCAGAGTTGCTGGAGAATGTAACCCTAATCCATAAACCAGTGTCGTTGCAA
CCCCGTGGGCTGATCAATAAAGGGAACTGGTGCTACATTAATGCTACACTGCAGGCATTGGTTGCTTGCCCGCCGATGTACCACCTGATG
AAGTTCATTCCTCTGTATTCCAAAGTGCAAAGGCCTTGTACGTCAACACCCATGATAGACAGCTTTGTTCGGCTAATGAATGAGTTCACT
AATATGCCAGTACCTCCAAAACCCCGACAAGCTCTTGGAGATAAAATCGTGAGGGATATTCGCCCTGGAGCTGCCTTTGAGCCCACATAT
ATTTACAGACTCCTGACAGTTAACAAGTCAAGCCTGTCTGAAAAGGGTCGACAAGAAGATGCTGAGGAATACTTAGGCTTCATTCTAAAT
GGACTTCATGAGGAAATGTTGAACCTAAAGAAGCTTCTCTCACCAAGTAATGAAAAACTTACGATTTCCAACGGCCCCAAAAACCACTCG
GTCAATGAAGAAGAGCAGGAAGAACAAGGTGAAGGAAGCGAGGATGAATGGGAACAAGTGGGCCCCCGGAACAAGACTTCCGTCACCCGC
CAGGCGGATTTTGTTCAGACTCCAATCACCGGCATTTTTGGTGGACACATCAGGTCTGTGGTTTACCAGCAGAGTTCAAAAGAATCTGCC
ACTTTGCAGCCATTTTTCACGTTGCAGTTGGATATCCAGTCAGACAAGATACGCACAGTCCAGGATGCACTGGAGAGCTTGGTGGCAAGA
GAATCTGTCCAAGGTTATACCACAAAAACCAAACAAGAGGTTGAGATAAGTCGAAGAGTGACTCTGGAAAAACTCCCTCCTGTCCTCGTG
CTGCACCTGAAACGATTCGTTTATGAGAAGACTGGTGGGTGCCAGAAGCTTATCAAAAATATTGAATATCCTGTGGACTTGGAAATTAGT
AAAGAACTGCTTTCTCCAGGGGTTAAAAATAAGAATTTTAAATGCCACCGAACCTATCGGCTCTTTGCAGTGGTCTACCATCACGGCAAC
AGTGCGACGGGCGGCCATTACACTACAGACGTCTTCCAGATCGGTCTGAATGGCTGGCTGCGCATCGATGACCAGACAGTCAAGGTGATC
AACCAGTACCAGGTGGTGAAACCAACTGCTGAACGCACAGCCTACCTCCTGTATTACCGCCGAGTGGACCTGCTGTAAACCCTGTGTGCG
CTGTGTGTGCGCCCAGTGCCCGCTTCGTAGGACACCACCTCACACTCACTTCCCGCCTCTCTTTAGTGGCTCTTTAGAGAGAAACTCTTT
CTCCCTTTGCAAAAATGGGCTAGAATGAAAAGGAGATGCCTTGGGGTTCGTGCACAACACAGCTTCTGTTGACTCTAACTTCCAAATCAA
AATCATTTGGTTGAAACAGACTGTTGCTTGATTTTAGAAAATACACAAAAACCCATATTTCTGAAATAATGCTGATTCCTGAGATAAGAA
AGTGGATTTGATCCCCAGTCTCATTGCTTAGTAGAATAAATCCTGCACCAGCAACAACACTTGTAAATTTGTGAAAATGAATTTTATCTT
TCCTTAAAAAAGAAATTTTTTAATCCATCACACTTTTCTTCCCTACCCTTTAGTTTTTGATAAATGATAAAAATGAGCCAGTTATCAAAG

>96575_96575_1_UCK2-USP10_UCK2_chr1_165797169_ENST00000367879_USP10_chr16_84767041_ENST00000219473_length(amino acids)=885AA_BP=94
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISSTLNPQAPEFILG
CTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGHANS
AVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPC
VGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYVETK
YSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQ
RPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLK
KLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPFFTLQL
DIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKN

--------------------------------------------------------------
>96575_96575_2_UCK2-USP10_UCK2_chr1_165797169_ENST00000367879_USP10_chr16_84767041_ENST00000570191_length(transcript)=2890nt_BP=402nt
CTCGCCGCCTCCGCCTCGGCGAATAGCAGCGCGCTGCCCGCCCGGATTGGAGCAGCAGCATCACGCTGACCTCTGCCTGGGATGTAAACC
GGACCAGCCGCTGCGGGCAAAGGAAGGCTCTTGGCTCCTTCGGGAAACCCAGCCCCGTCACCGGGCTCCGAGCGGCTCGCAGGCGAGCGA
CAGCGGCCTCAGCCCCGGCAGCGCCCAGCGGCGGCTGCGGAAAGCGGAGGGAGTCCGACGCGGGCGCGGGCGGGGAGCGTGCGTCCGTTC
GCACAGGCAGCGGGAGGAGGGGCGGCGCGAACCATGGCCGGGGACAGCGAGCAGACCCTGCAGAACCACCAGCAGCCCAACGGCGGCGAG
CCCTTCCTTATAGGCGTCAGCGGGGGAACAGCTAGCGGCAAGTATATTTTTGGAGATTTTAGCCCTGATGAATTCAATCAATTCTTTGTG
ACTCCTCGATCTTCAGTTGAGCTTCCTCCATACAGTGGAACAGTTCTGTGTGGCACACAGGCTGTGGATAAACTACCTGATGGACAAGAA
TATCAGAGAATTGAGTTTGGTGTCGATGAAGTCATTGAACCCAGTGACACTTTGCCGAGAACCCCCAGCTACAGTATTTCAAGCACACTG
AACCCTCAGGCCCCTGAATTTATTCTCGGTTGTACAGCTTCCAAAATAACCCCTGATGGTATCACTAAAGAAGCAAGCTATGGCTCCATC
GACTGCCAGTACCCAGGCTCTGCCCTCGCTTTGGATGGAAGTTCTAATGTGGAGGCGGAAGTTTTGGAAAATGATGGTGTCTCAGGTGGT
CTTGGACAAAGGGAGCGTAAAAAGAAGAAAAAGCGGCCACCTGGATATTACAGCTATTTGAAAGATGGTGGCGATGATAGTATCTCCACA
GAAGCCCTGGTCAATGGCCATGCCAATTCAGCAGTCCCGAACAGTGTCAGTGCAGAGGATGCAGAATTTATGGGTGACATGCCCCCGTCA
GTTACGCCCAGGACTTGTAACAGCCCCCAGAACTCCACAGACTCTGTCAGTGACATTGTGCCTGACAGTCCTTTCCCCGGAGCACTCGGC
AGTGACACCAGGACTGCAGGGCAGCCAGAGGGGGGCCCCGGGGCTGATTTTGGTCAGTCCTGCTTCCCTGCAGAGGCTGGCAGAGACACC
CTGTCAAGGACAGCTGGGGCTCAGCCCTGCGTTGGTACCGATACTACTGAAAACCTTGGAGTTGCTAATGGACAAATACTTGAATCCTCG
GGTGAGGGCACAGCTACCAACGGGGTGGAGTTGCACACCACGGAAAGCATAGACTTGGACCCAACCAAACCCGAGAGTGCATCACCTCCT
GCTGACGGCACGGGCTCTGCATCAGGCACCCTTCCTGTCAGCCAGCCCAAGTCCTGGGCCAGCCTCTTTCATGATTCTAAGCCCTCTTCC
TCCTCGCCGGTGGCCTATGTGGAAACTAAGTATTCCCCTCCCGCCATATCTCCCCTGGTTTCTGAAAAGCAGGTTGAAGTCAAAGAAGGG
CTTGTTCCGGTTTCAGAGGATCCTGTAGCCATAAAGATTGCAGAGTTGCTGGAGAATGTAACCCTAATCCATAAACCAGTGTCGTTGCAA
CCCCGTGGGCTGATCAATAAAGGGAACTGGTGCTACATTAATGCTACACTGCAGGCATTGGTTGCTTGCCCGCCGATGTACCACCTGATG
AAGTTCATTCCTCTGTATTCCAAAGTGCAAAGGCCTTGTACGTCAACACCCATGATAGACAGCTTTGTTCGGCTAATGAATGAGTTCACT
AATATGCCAGTACCTCCAAAACCCCGACAAGCTCTTGGAGATAAAATCGTGAGGGATATTCGCCCTGGAGCTGCCTTTGAGCCCACATAT
ATTTACAGACTCCTGACAGTTAACAAGTCAAGCCTGTCTGAAAAGGGTCGACAAGAAGATGCTGAGGAATACTTAGGCTTCATTCTAAAT
GGACTTCATGAGGAAATGTTGAACCTAAAGAAGCTTCTCTCACCAAGTAATGAAAAACTTACGATTTCCAACGGCCCCAAAAACCACTCG
GTCAATGAAGAAGAGCAGGAAGAACAAGGTGAAGGAAGCGAGGATGAATGGGAACAAGTGGGCCCCCGGAACAAGACTTCCGTCACCCGC
CAGGCGGATTTTGTTCAGACTCCAATCACCGGCATTTTTGGTGGACACATCAGGTCTGTGGTTTACCAGCAGAGTTCAAAAGAATCTGCC
ACTTTGCAGCCATTTTTCACGTTGCAGTTGGATATCCAGTCAGACAAGATACGCACAGTCCAGGATGCACTGGAGAGCTTGGTGGCAAGA
GAATCTGTCCAAGGTTATACCACAAAAACCAAACAAGAGGTTGAGATAAGTCGAAGAGTGACTCTGGAAAAACTCCCTCCTGTCCTCGTG
CTGCACCTGAAACGATTCGTTTATGAGAAGACTGGTGGGTGCCAGAAGCTTATCAAAAATATTGAATATCCTGTGGACTTGGAAATTAGT
AAAGAACTGCTTTCTCCAGGGGTTAAAAATAAGAATTTTAAATGCCACCGAACCTATCGGCTCTTTGCAGTGGTCTACCATCACGGCAAC
AGTGCGACGGGCGGCCATTACACTACAGACGTCTTCCAGATCGGTCTGAATGGCTGGCTGCGCATCGATGACCAGACAGTCAAGGTGATC
AACCAGTACCAGGTGGTGAAACCAACTGCTGAACGCACAGCCTACCTCCTGTATTACCGCCGAGTGGACCTGCTGTAAACCCTGTGTGCG
CTGTGTGTGCGCCCAGTGCCCGCTTCGTAGGACACCACCTCACACTCACTTCCCGCCTCTCTTTAGTGGCTCTTTAGAGAGAAACTCTTT

>96575_96575_2_UCK2-USP10_UCK2_chr1_165797169_ENST00000367879_USP10_chr16_84767041_ENST00000570191_length(amino acids)=885AA_BP=94
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFGVDEVIEPSDTLPRTPSYSISSTLNPQAPEFILG
CTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKKRPPGYYSYLKDGGDDSISTEALVNGHANS
AVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAGQPEGGPGADFGQSCFPAEAGRDTLSRTAGAQPC
VGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGSASGTLPVSQPKSWASLFHDSKPSSSSPVAYVETK
YSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWCYINATLQALVACPPMYHLMKFIPLYSKVQ
RPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSSLSEKGRQEDAEEYLGFILNGLHEEMLNLK
KLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITGIFGGHIRSVVYQQSSKESATLQPFFTLQL
DIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKN

--------------------------------------------------------------
>96575_96575_3_UCK2-USP10_UCK2_chr1_165797169_ENST00000372212_USP10_chr16_84767041_ENST00000219473_length(transcript)=2986nt_BP=111nt
GCGGCGCGAACCATGGCCGGGGACAGCGAGCAGACCCTGCAGAACCACCAGCAGCCCAACGGCGGCGAGCCCTTCCTTATAGGCGTCAGC
GGGGGAACAGCTAGCGGCAAGTATATTTTTGGAGATTTTAGCCCTGATGAATTCAATCAATTCTTTGTGACTCCTCGATCTTCAGTTGAG
CTTCCTCCATACAGTGGAACAGTTCTGTGTGGCACACAGGCTGTGGATAAACTACCTGATGGACAAGAATATCAGAGAATTGAGTTTGGT
GTCGATGAAGTCATTGAACCCAGTGACACTTTGCCGAGAACCCCCAGCTACAGTATTTCAAGCACACTGAACCCTCAGGCCCCTGAATTT
ATTCTCGGTTGTACAGCTTCCAAAATAACCCCTGATGGTATCACTAAAGAAGCAAGCTATGGCTCCATCGACTGCCAGTACCCAGGCTCT
GCCCTCGCTTTGGATGGAAGTTCTAATGTGGAGGCGGAAGTTTTGGAAAATGATGGTGTCTCAGGTGGTCTTGGACAAAGGGAGCGTAAA
AAGAAGAAAAAGCGGCCACCTGGATATTACAGCTATTTGAAAGATGGTGGCGATGATAGTATCTCCACAGAAGCCCTGGTCAATGGCCAT
GCCAATTCAGCAGTCCCGAACAGTGTCAGTGCAGAGGATGCAGAATTTATGGGTGACATGCCCCCGTCAGTTACGCCCAGGACTTGTAAC
AGCCCCCAGAACTCCACAGACTCTGTCAGTGACATTGTGCCTGACAGTCCTTTCCCCGGAGCACTCGGCAGTGACACCAGGACTGCAGGG
CAGCCAGAGGGGGGCCCCGGGGCTGATTTTGGTCAGTCCTGCTTCCCTGCAGAGGCTGGCAGAGACACCCTGTCAAGGACAGCTGGGGCT
CAGCCCTGCGTTGGTACCGATACTACTGAAAACCTTGGAGTTGCTAATGGACAAATACTTGAATCCTCGGGTGAGGGCACAGCTACCAAC
GGGGTGGAGTTGCACACCACGGAAAGCATAGACTTGGACCCAACCAAACCCGAGAGTGCATCACCTCCTGCTGACGGCACGGGCTCTGCA
TCAGGCACCCTTCCTGTCAGCCAGCCCAAGTCCTGGGCCAGCCTCTTTCATGATTCTAAGCCCTCTTCCTCCTCGCCGGTGGCCTATGTG
GAAACTAAGTATTCCCCTCCCGCCATATCTCCCCTGGTTTCTGAAAAGCAGGTTGAAGTCAAAGAAGGGCTTGTTCCGGTTTCAGAGGAT
CCTGTAGCCATAAAGATTGCAGAGTTGCTGGAGAATGTAACCCTAATCCATAAACCAGTGTCGTTGCAACCCCGTGGGCTGATCAATAAA
GGGAACTGGTGCTACATTAATGCTACACTGCAGGCATTGGTTGCTTGCCCGCCGATGTACCACCTGATGAAGTTCATTCCTCTGTATTCC
AAAGTGCAAAGGCCTTGTACGTCAACACCCATGATAGACAGCTTTGTTCGGCTAATGAATGAGTTCACTAATATGCCAGTACCTCCAAAA
CCCCGACAAGCTCTTGGAGATAAAATCGTGAGGGATATTCGCCCTGGAGCTGCCTTTGAGCCCACATATATTTACAGACTCCTGACAGTT
AACAAGTCAAGCCTGTCTGAAAAGGGTCGACAAGAAGATGCTGAGGAATACTTAGGCTTCATTCTAAATGGACTTCATGAGGAAATGTTG
AACCTAAAGAAGCTTCTCTCACCAAGTAATGAAAAACTTACGATTTCCAACGGCCCCAAAAACCACTCGGTCAATGAAGAAGAGCAGGAA
GAACAAGGTGAAGGAAGCGAGGATGAATGGGAACAAGTGGGCCCCCGGAACAAGACTTCCGTCACCCGCCAGGCGGATTTTGTTCAGACT
CCAATCACCGGCATTTTTGGTGGACACATCAGGTCTGTGGTTTACCAGCAGAGTTCAAAAGAATCTGCCACTTTGCAGCCATTTTTCACG
TTGCAGTTGGATATCCAGTCAGACAAGATACGCACAGTCCAGGATGCACTGGAGAGCTTGGTGGCAAGAGAATCTGTCCAAGGTTATACC
ACAAAAACCAAACAAGAGGTTGAGATAAGTCGAAGAGTGACTCTGGAAAAACTCCCTCCTGTCCTCGTGCTGCACCTGAAACGATTCGTT
TATGAGAAGACTGGTGGGTGCCAGAAGCTTATCAAAAATATTGAATATCCTGTGGACTTGGAAATTAGTAAAGAACTGCTTTCTCCAGGG
GTTAAAAATAAGAATTTTAAATGCCACCGAACCTATCGGCTCTTTGCAGTGGTCTACCATCACGGCAACAGTGCGACGGGCGGCCATTAC
ACTACAGACGTCTTCCAGATCGGTCTGAATGGCTGGCTGCGCATCGATGACCAGACAGTCAAGGTGATCAACCAGTACCAGGTGGTGAAA
CCAACTGCTGAACGCACAGCCTACCTCCTGTATTACCGCCGAGTGGACCTGCTGTAAACCCTGTGTGCGCTGTGTGTGCGCCCAGTGCCC
GCTTCGTAGGACACCACCTCACACTCACTTCCCGCCTCTCTTTAGTGGCTCTTTAGAGAGAAACTCTTTCTCCCTTTGCAAAAATGGGCT
AGAATGAAAAGGAGATGCCTTGGGGTTCGTGCACAACACAGCTTCTGTTGACTCTAACTTCCAAATCAAAATCATTTGGTTGAAACAGAC
TGTTGCTTGATTTTAGAAAATACACAAAAACCCATATTTCTGAAATAATGCTGATTCCTGAGATAAGAAAGTGGATTTGATCCCCAGTCT
CATTGCTTAGTAGAATAAATCCTGCACCAGCAACAACACTTGTAAATTTGTGAAAATGAATTTTATCTTTCCTTAAAAAAGAAATTTTTT
AATCCATCACACTTTTCTTCCCTACCCTTTAGTTTTTGATAAATGATAAAAATGAGCCAGTTATCAAAGAAGAACTAGTTCTTACTTCAA

>96575_96575_3_UCK2-USP10_UCK2_chr1_165797169_ENST00000372212_USP10_chr16_84767041_ENST00000219473_length(amino acids)=824AA_BP=33
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFGVDEV
IEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKK
RPPGYYSYLKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAGQPEG
GPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGSASGTL
PVSQPKSWASLFHDSKPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWC
YINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSS
LSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITG
IFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKT
GGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVKPTAE

--------------------------------------------------------------
>96575_96575_4_UCK2-USP10_UCK2_chr1_165797169_ENST00000372212_USP10_chr16_84767041_ENST00000570191_length(transcript)=2599nt_BP=111nt
GCGGCGCGAACCATGGCCGGGGACAGCGAGCAGACCCTGCAGAACCACCAGCAGCCCAACGGCGGCGAGCCCTTCCTTATAGGCGTCAGC
GGGGGAACAGCTAGCGGCAAGTATATTTTTGGAGATTTTAGCCCTGATGAATTCAATCAATTCTTTGTGACTCCTCGATCTTCAGTTGAG
CTTCCTCCATACAGTGGAACAGTTCTGTGTGGCACACAGGCTGTGGATAAACTACCTGATGGACAAGAATATCAGAGAATTGAGTTTGGT
GTCGATGAAGTCATTGAACCCAGTGACACTTTGCCGAGAACCCCCAGCTACAGTATTTCAAGCACACTGAACCCTCAGGCCCCTGAATTT
ATTCTCGGTTGTACAGCTTCCAAAATAACCCCTGATGGTATCACTAAAGAAGCAAGCTATGGCTCCATCGACTGCCAGTACCCAGGCTCT
GCCCTCGCTTTGGATGGAAGTTCTAATGTGGAGGCGGAAGTTTTGGAAAATGATGGTGTCTCAGGTGGTCTTGGACAAAGGGAGCGTAAA
AAGAAGAAAAAGCGGCCACCTGGATATTACAGCTATTTGAAAGATGGTGGCGATGATAGTATCTCCACAGAAGCCCTGGTCAATGGCCAT
GCCAATTCAGCAGTCCCGAACAGTGTCAGTGCAGAGGATGCAGAATTTATGGGTGACATGCCCCCGTCAGTTACGCCCAGGACTTGTAAC
AGCCCCCAGAACTCCACAGACTCTGTCAGTGACATTGTGCCTGACAGTCCTTTCCCCGGAGCACTCGGCAGTGACACCAGGACTGCAGGG
CAGCCAGAGGGGGGCCCCGGGGCTGATTTTGGTCAGTCCTGCTTCCCTGCAGAGGCTGGCAGAGACACCCTGTCAAGGACAGCTGGGGCT
CAGCCCTGCGTTGGTACCGATACTACTGAAAACCTTGGAGTTGCTAATGGACAAATACTTGAATCCTCGGGTGAGGGCACAGCTACCAAC
GGGGTGGAGTTGCACACCACGGAAAGCATAGACTTGGACCCAACCAAACCCGAGAGTGCATCACCTCCTGCTGACGGCACGGGCTCTGCA
TCAGGCACCCTTCCTGTCAGCCAGCCCAAGTCCTGGGCCAGCCTCTTTCATGATTCTAAGCCCTCTTCCTCCTCGCCGGTGGCCTATGTG
GAAACTAAGTATTCCCCTCCCGCCATATCTCCCCTGGTTTCTGAAAAGCAGGTTGAAGTCAAAGAAGGGCTTGTTCCGGTTTCAGAGGAT
CCTGTAGCCATAAAGATTGCAGAGTTGCTGGAGAATGTAACCCTAATCCATAAACCAGTGTCGTTGCAACCCCGTGGGCTGATCAATAAA
GGGAACTGGTGCTACATTAATGCTACACTGCAGGCATTGGTTGCTTGCCCGCCGATGTACCACCTGATGAAGTTCATTCCTCTGTATTCC
AAAGTGCAAAGGCCTTGTACGTCAACACCCATGATAGACAGCTTTGTTCGGCTAATGAATGAGTTCACTAATATGCCAGTACCTCCAAAA
CCCCGACAAGCTCTTGGAGATAAAATCGTGAGGGATATTCGCCCTGGAGCTGCCTTTGAGCCCACATATATTTACAGACTCCTGACAGTT
AACAAGTCAAGCCTGTCTGAAAAGGGTCGACAAGAAGATGCTGAGGAATACTTAGGCTTCATTCTAAATGGACTTCATGAGGAAATGTTG
AACCTAAAGAAGCTTCTCTCACCAAGTAATGAAAAACTTACGATTTCCAACGGCCCCAAAAACCACTCGGTCAATGAAGAAGAGCAGGAA
GAACAAGGTGAAGGAAGCGAGGATGAATGGGAACAAGTGGGCCCCCGGAACAAGACTTCCGTCACCCGCCAGGCGGATTTTGTTCAGACT
CCAATCACCGGCATTTTTGGTGGACACATCAGGTCTGTGGTTTACCAGCAGAGTTCAAAAGAATCTGCCACTTTGCAGCCATTTTTCACG
TTGCAGTTGGATATCCAGTCAGACAAGATACGCACAGTCCAGGATGCACTGGAGAGCTTGGTGGCAAGAGAATCTGTCCAAGGTTATACC
ACAAAAACCAAACAAGAGGTTGAGATAAGTCGAAGAGTGACTCTGGAAAAACTCCCTCCTGTCCTCGTGCTGCACCTGAAACGATTCGTT
TATGAGAAGACTGGTGGGTGCCAGAAGCTTATCAAAAATATTGAATATCCTGTGGACTTGGAAATTAGTAAAGAACTGCTTTCTCCAGGG
GTTAAAAATAAGAATTTTAAATGCCACCGAACCTATCGGCTCTTTGCAGTGGTCTACCATCACGGCAACAGTGCGACGGGCGGCCATTAC
ACTACAGACGTCTTCCAGATCGGTCTGAATGGCTGGCTGCGCATCGATGACCAGACAGTCAAGGTGATCAACCAGTACCAGGTGGTGAAA
CCAACTGCTGAACGCACAGCCTACCTCCTGTATTACCGCCGAGTGGACCTGCTGTAAACCCTGTGTGCGCTGTGTGTGCGCCCAGTGCCC

>96575_96575_4_UCK2-USP10_UCK2_chr1_165797169_ENST00000372212_USP10_chr16_84767041_ENST00000570191_length(amino acids)=824AA_BP=33
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKYIFGDFSPDEFNQFFVTPRSSVELPPYSGTVLCGTQAVDKLPDGQEYQRIEFGVDEV
IEPSDTLPRTPSYSISSTLNPQAPEFILGCTASKITPDGITKEASYGSIDCQYPGSALALDGSSNVEAEVLENDGVSGGLGQRERKKKKK
RPPGYYSYLKDGGDDSISTEALVNGHANSAVPNSVSAEDAEFMGDMPPSVTPRTCNSPQNSTDSVSDIVPDSPFPGALGSDTRTAGQPEG
GPGADFGQSCFPAEAGRDTLSRTAGAQPCVGTDTTENLGVANGQILESSGEGTATNGVELHTTESIDLDPTKPESASPPADGTGSASGTL
PVSQPKSWASLFHDSKPSSSSPVAYVETKYSPPAISPLVSEKQVEVKEGLVPVSEDPVAIKIAELLENVTLIHKPVSLQPRGLINKGNWC
YINATLQALVACPPMYHLMKFIPLYSKVQRPCTSTPMIDSFVRLMNEFTNMPVPPKPRQALGDKIVRDIRPGAAFEPTYIYRLLTVNKSS
LSEKGRQEDAEEYLGFILNGLHEEMLNLKKLLSPSNEKLTISNGPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKTSVTRQADFVQTPITG
IFGGHIRSVVYQQSSKESATLQPFFTLQLDIQSDKIRTVQDALESLVARESVQGYTTKTKQEVEISRRVTLEKLPPVLVLHLKRFVYEKT
GGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQIGLNGWLRIDDQTVKVINQYQVVKPTAE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UCK2-USP10

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	USP10	chr1:165797169	chr16:84767041	ENST00000219473		0	14	2_100	7.0	799.0	p53/TP53
Tgene	USP10	chr1:165797169	chr16:84767041	ENST00000570191		1	15	2_100	11.0	803.0	p53/TP53

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for UCK2-USP10

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for UCK2-USP10

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source