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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UGP2-PLEKHM3 (FusionGDB2 ID:96655)

Fusion Gene Summary for UGP2-PLEKHM3

check button Fusion gene summary
Fusion gene informationFusion gene name: UGP2-PLEKHM3
Fusion gene ID: 96655
HgeneTgene
Gene symbol

UGP2

PLEKHM3

Gene ID

7360

389072

Gene nameUDP-glucose pyrophosphorylase 2pleckstrin homology domain containing M3
SynonymsEIEE83|SVUGP2|UDPG|UDPGP|UDPGP2|UGP1|UGPP1|UGPP2|pHC379DAPR|PLEKHM1L
Cytomap

2p15

2q33.3

Type of geneprotein-codingprotein-coding
DescriptionUTP--glucose-1-phosphate uridylyltransferaseUDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1testipleckstrin homology domain-containing family M member 3PH domain-containing family M member 3differentiation associated protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000337130, ENST00000394417, 
ENST00000445915, ENST00000467648, 
ENST00000487469, 		ENST00000389247, 
ENST00000427836, ENST00000457206, 
Fusion gene scores* DoF score6 X 4 X 4=967 X 4 X 5=140
# samples 66
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/140*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UGP2 [Title/Abstract] AND PLEKHM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUGP2(64085070)-PLEKHM3(208795843), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across UGP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLEKHM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-8083-01AUGP2chr2

64085070

-PLEKHM3chr2

208795843

-
ChimerDB4LUSCTCGA-56-8083-01AUGP2chr2

64085070

+PLEKHM3chr2

208795843

-
ChimerDB4LUSCTCGA-56-8083UGP2chr2

64085070

+PLEKHM3chr2

208795843

-


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Fusion Gene ORF analysis for UGP2-PLEKHM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000337130ENST00000389247UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000337130ENST00000427836UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000337130ENST00000457206UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000394417ENST00000389247UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000394417ENST00000427836UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000394417ENST00000457206UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000445915ENST00000389247UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000445915ENST00000427836UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000445915ENST00000457206UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000467648ENST00000389247UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000467648ENST00000427836UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
In-frameENST00000467648ENST00000457206UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
intron-3CDSENST00000487469ENST00000389247UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
intron-3CDSENST00000487469ENST00000427836UGP2chr2

64085070

+PLEKHM3chr2

208795843

-
intron-3CDSENST00000487469ENST00000457206UGP2chr2

64085070

+PLEKHM3chr2

208795843

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394417UGP2chr264085070+ENST00000427836PLEKHM3chr2208795843-11395292741122282
ENST00000394417UGP2chr264085070+ENST00000389247PLEKHM3chr2208795843-991529274990239
ENST00000394417UGP2chr264085070+ENST00000457206PLEKHM3chr2208795843-2098529274855193
ENST00000467648UGP2chr264085070+ENST00000427836PLEKHM3chr2208795843-11715613391154271
ENST00000467648UGP2chr264085070+ENST00000389247PLEKHM3chr2208795843-10235613391022227
ENST00000467648UGP2chr264085070+ENST00000457206PLEKHM3chr2208795843-2130561339887182
ENST00000337130UGP2chr264085070+ENST00000427836PLEKHM3chr2208795843-13417314761324282
ENST00000337130UGP2chr264085070+ENST00000389247PLEKHM3chr2208795843-11937314761192239
ENST00000337130UGP2chr264085070+ENST00000457206PLEKHM3chr2208795843-23007314761057193
ENST00000445915UGP2chr264085070+ENST00000427836PLEKHM3chr2208795843-95934967942291
ENST00000445915UGP2chr264085070+ENST00000389247PLEKHM3chr2208795843-81134967810248
ENST00000445915UGP2chr264085070+ENST00000457206PLEKHM3chr2208795843-191834967675202

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394417ENST00000427836UGP2chr264085070+PLEKHM3chr2208795843-0.0073742640.9926258
ENST00000394417ENST00000389247UGP2chr264085070+PLEKHM3chr2208795843-0.0043918610.99560815
ENST00000394417ENST00000457206UGP2chr264085070+PLEKHM3chr2208795843-0.0047188670.99528116
ENST00000467648ENST00000427836UGP2chr264085070+PLEKHM3chr2208795843-0.0080747910.9919252
ENST00000467648ENST00000389247UGP2chr264085070+PLEKHM3chr2208795843-0.0049653120.9950347
ENST00000467648ENST00000457206UGP2chr264085070+PLEKHM3chr2208795843-0.0050893550.99491066
ENST00000337130ENST00000427836UGP2chr264085070+PLEKHM3chr2208795843-0.0044850130.9955149
ENST00000337130ENST00000389247UGP2chr264085070+PLEKHM3chr2208795843-0.0024499770.9975501
ENST00000337130ENST00000457206UGP2chr264085070+PLEKHM3chr2208795843-0.0033484390.9966516
ENST00000445915ENST00000427836UGP2chr264085070+PLEKHM3chr2208795843-0.0091872110.9908127
ENST00000445915ENST00000389247UGP2chr264085070+PLEKHM3chr2208795843-0.0034012270.9965988
ENST00000445915ENST00000457206UGP2chr264085070+PLEKHM3chr2208795843-0.0035567480.9964432

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Fusion Genomic Features for UGP2-PLEKHM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UGP2-PLEKHM3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:64085070/chr2:208795843)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000038924738669_722564718.0Zinc fingerNote=Phorbol-ester/DAG-type
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000042783638669_722564762.0Zinc fingerNote=Phorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUGP2chr2:64085070chr2:208795843ENST00000337130+310113_11685509.0RegionUTP binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000337130+310115_11685509.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000337130+310251_25385509.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000337130+310457_50885509.0RegionNote=Oligomerization
HgeneUGP2chr2:64085070chr2:208795843ENST00000394417+310113_11674498.0RegionUTP binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000394417+310115_11674498.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000394417+310251_25374498.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000394417+310457_50874498.0RegionNote=Oligomerization
HgeneUGP2chr2:64085070chr2:208795843ENST00000467648+411113_11674498.0RegionUTP binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000467648+411115_11674498.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000467648+411251_25374498.0RegionSubstrate binding
HgeneUGP2chr2:64085070chr2:208795843ENST00000467648+411457_50874498.0RegionNote=Oligomerization
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000038924738169_175564718.0Compositional biasNote=Poly-Gln
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000042783638169_175564762.0Compositional biasNote=Poly-Gln
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000038924738211_308564718.0DomainPH 1
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000038924738361_456564718.0DomainPH 2
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000042783638211_308564762.0DomainPH 1
TgenePLEKHM3chr2:64085070chr2:208795843ENST0000042783638361_456564762.0DomainPH 2


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Fusion Gene Sequence for UGP2-PLEKHM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96655_96655_1_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000337130_PLEKHM3_chr2_208795843_ENST00000389247_length(transcript)=1193nt_BP=731nt
GGTTTTCGGGGGAGGCGTTTGGGGCCTGGACGGCGGCGCGGGGAGGGGGCAGCTAGGGGCGCGGCCTGCCAGTGCCTCCTGCAGTACAGC
CCTGGAGGGCGTGGGGACTTGGGGGCGGTGAAATAGCCGCTGTAGGTCCGCCTCTTTCATTGAAGAAATTTAAGTTCGTGTGGTTTTACC
TTTTCCGGGAGTCTCCAGCTGGCCCTCATTTGTGTCCGGAGCTCAGGAGTTCCCAAACCGACTCAGTCGCACCAAGTTTCCGTCTTTTGG
AATTGGGGAAGGAGTTTCTTTCTTTCTTTTCTTTTTTCTTGAGCCAGTTTTAATCGCTTTGAATAAATACTCCCTTAAGTAGTTAAATAT
AGGAGGAGAAAGAATACATCGGTTGTTAAAGCAGGAGAGGAAGAGAGACCTGCCCTGTAGCGTGACTCCTCTAGAAAAAAAAAAAAAAAG
CCGGAGTATTTTACTAAGCCCCTAAAATGTCGAGATTTGTACAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAG
AAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCA
AAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCC
CTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGC
TGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAG
CGGTGGCAGAGGATCTCCGCCGCAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGG
TAATAGAGGGAAAGCTGGCTCCATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGG
GGTTCATCTGTGAAATCTGTAACAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGATTCGGAGACCCATATGCAGATT

>96655_96655_1_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000337130_PLEKHM3_chr2_208795843_ENST00000389247_length(amino acids)=239AA_BP=85
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF

--------------------------------------------------------------
>96655_96655_2_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000337130_PLEKHM3_chr2_208795843_ENST00000427836_length(transcript)=1341nt_BP=731nt
GGTTTTCGGGGGAGGCGTTTGGGGCCTGGACGGCGGCGCGGGGAGGGGGCAGCTAGGGGCGCGGCCTGCCAGTGCCTCCTGCAGTACAGC
CCTGGAGGGCGTGGGGACTTGGGGGCGGTGAAATAGCCGCTGTAGGTCCGCCTCTTTCATTGAAGAAATTTAAGTTCGTGTGGTTTTACC
TTTTCCGGGAGTCTCCAGCTGGCCCTCATTTGTGTCCGGAGCTCAGGAGTTCCCAAACCGACTCAGTCGCACCAAGTTTCCGTCTTTTGG
AATTGGGGAAGGAGTTTCTTTCTTTCTTTTCTTTTTTCTTGAGCCAGTTTTAATCGCTTTGAATAAATACTCCCTTAAGTAGTTAAATAT
AGGAGGAGAAAGAATACATCGGTTGTTAAAGCAGGAGAGGAAGAGAGACCTGCCCTGTAGCGTGACTCCTCTAGAAAAAAAAAAAAAAAG
CCGGAGTATTTTACTAAGCCCCTAAAATGTCGAGATTTGTACAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAG
AAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCA
AAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCC
CTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGC
TGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAG
CGGTGGCAGAGGATCTCCGCCGCAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGG
TAATAGAGGGAAAGCTGGCTCCATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGG
GGTTCATCTGTGAAATCTGTAACAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGGTGTGAAAGCTGTGGAGCCGTTT
TCCATTCTGAATGCAAAGAAAAGTCTGTCCCCTGCCCGAGGTGTGTTCGCCGAGAGCTGCAGAAGAAGCAGAAGTCTTTCTGGCAGAGAC

>96655_96655_2_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000337130_PLEKHM3_chr2_208795843_ENST00000427836_length(amino acids)=282AA_BP=85
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF
LGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEE

--------------------------------------------------------------
>96655_96655_3_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000337130_PLEKHM3_chr2_208795843_ENST00000457206_length(transcript)=2300nt_BP=731nt
GGTTTTCGGGGGAGGCGTTTGGGGCCTGGACGGCGGCGCGGGGAGGGGGCAGCTAGGGGCGCGGCCTGCCAGTGCCTCCTGCAGTACAGC
CCTGGAGGGCGTGGGGACTTGGGGGCGGTGAAATAGCCGCTGTAGGTCCGCCTCTTTCATTGAAGAAATTTAAGTTCGTGTGGTTTTACC
TTTTCCGGGAGTCTCCAGCTGGCCCTCATTTGTGTCCGGAGCTCAGGAGTTCCCAAACCGACTCAGTCGCACCAAGTTTCCGTCTTTTGG
AATTGGGGAAGGAGTTTCTTTCTTTCTTTTCTTTTTTCTTGAGCCAGTTTTAATCGCTTTGAATAAATACTCCCTTAAGTAGTTAAATAT
AGGAGGAGAAAGAATACATCGGTTGTTAAAGCAGGAGAGGAAGAGAGACCTGCCCTGTAGCGTGACTCCTCTAGAAAAAAAAAAAAAAAG
CCGGAGTATTTTACTAAGCCCCTAAAATGTCGAGATTTGTACAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAG
AAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCA
AAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCC
CTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGC
TGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAG
CGGTGGCAGAGGATCTCCGCCGCAGAAATGACCAGCAGCATGCATTAGTCATGTTAAATGTTTTTGGAGAATTTTCCCCAGAGAATACCT
CCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGACCCAGGCACTACAGCCAAATCTAACCTGATCCACAGATGATTGAAG
GATCGGGGGAGCTCGGCACGGGATGTGGCAGCAAATGTGCGGCACTAAGGACAAAGTCACTGCCTTTTGTGGAAGCCAGATCAGAAAGAT
GACTGTGTGTTGTGAGTGGTGGATAGAGAGCCCTGTTGCCCAGGTGAGAAGGAGCTCAGTTGAGATAAGGATTCCAGGAGCCAACTCGAG
CCCCTCAGGTAGAGACAACAATACCGGTTGAGGCTGCAGCTGTGGAGTTGGATGGTGTTTAGTCAGTGCTGAAATCACTTTCCTGGGAGT
CCCTTGGCATGCAGTCATCTGAGTGCTGTTGTTGTTGTTGGGTTTTTGTTGTTTCCTATTTTAAAAGAGTAATCATAATACTGACGAAGT
GAGGGCCTGTTTTCAAAGAACATTTACTTAAAGATATAGAGTAAGGTTAGCATCGGTCTTGCCAGTGGTAGAAACCTATGCCACCAACAG
CCATCATGAAAGGGCCCCAGGAGTCTTTCTGGTTCTTCATTTCTATTCAGTTTGATTCAACAAGTGTGTATTGATTGAATGCTTTCTGTG
TGCCAATCATTGAGCTAGCCACAGAGGAGGCAAAGGTGATTAAGCCACAATTCCTTCCCTCACTGAGCTCACAGTCTGATGAGAGAGGCA
GATAGGCATTGTTGAAGTCAGCGGAGTTGAACCTAGGGTACTTGGGGAATACATCTGACCAAGTGTGTGGCAGATTGTATTTTGCAAAAA
TAGCTGCAACAGTATCTTCCATCCCACATGTCTTTCTTACACTGTGACTTTGATGCTCCTCCTATTCAGTAGTGAGATCTGTGTTCCTTC
TCCCCGAATTTGGGCAGGTCTGTGACTATGGAAGTGATGCCATGTGATTTCCAAAGCCAAGTCATAAAAGGTGATATAGCTCCAACCTGG
TGCTGTCTGGAGATGCTCACTCATGGCAACCCAGTGGCCATGTTGTAAGGAAGTCCAGATTAGCCCTCATAGAACAACCACATGAACAGG
CCTCATATGGTAGTTGTTCTAGCTGGCAGCGATCATCAGCCACCAGAGAGATGAGTGAAGACAGCCCCACATGATTCCAGCTGCTAGCCT
TCAAGTCTTCTCACCTAGGCTAGAGATGAGGCTGCAGATATTATGGAGCAGAAACAAACCATCTCCACAGTGTCCTTCCTGGAGTCCTGA

>96655_96655_3_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000337130_PLEKHM3_chr2_208795843_ENST00000457206_length(amino acids)=193AA_BP=85
MSRFVQDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENTSFNRSTCIH

--------------------------------------------------------------
>96655_96655_4_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000394417_PLEKHM3_chr2_208795843_ENST00000389247_length(transcript)=991nt_BP=529nt
CTGTCGGTCCGTGCGGCAGGGACATTTCCGCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCT
GTGGGTGTCGGGAGCCGGCTGACGGGTGGACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGT
GAGGGAAGAGAGAGAGAGAGAAGGGCGCCTCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTC
CCAGCTGCTAAAGGAAGAGGAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGGTAATAGAGGGAAAGCTGGCTCC
ATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGGGGTTCATCTGTGAAATCTGTAA
CAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGATTCGGAGACCCATATGCAGATTTATTACAAGGATATGTGGCCTG

>96655_96655_4_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000394417_PLEKHM3_chr2_208795843_ENST00000389247_length(amino acids)=239AA_BP=85
MLKEEEDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF

--------------------------------------------------------------
>96655_96655_5_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000394417_PLEKHM3_chr2_208795843_ENST00000427836_length(transcript)=1139nt_BP=529nt
CTGTCGGTCCGTGCGGCAGGGACATTTCCGCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCT
GTGGGTGTCGGGAGCCGGCTGACGGGTGGACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGT
GAGGGAAGAGAGAGAGAGAGAAGGGCGCCTCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTC
CCAGCTGCTAAAGGAAGAGGAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGGTAATAGAGGGAAAGCTGGCTCC
ATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGGGGTTCATCTGTGAAATCTGTAA
CAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGGTGTGAAAGCTGTGGAGCCGTTTTCCATTCTGAATGCAAAGAAAA
GTCTGTCCCCTGCCCGAGGTGTGTTCGCCGAGAGCTGCAGAAGAAGCAGAAGTCTTTCTGGCAGAGACTGAACATGGACGAGAGTCTAGA

>96655_96655_5_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000394417_PLEKHM3_chr2_208795843_ENST00000427836_length(amino acids)=282AA_BP=85
MLKEEEDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPF
LGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEE

--------------------------------------------------------------
>96655_96655_6_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000394417_PLEKHM3_chr2_208795843_ENST00000457206_length(transcript)=2098nt_BP=529nt
CTGTCGGTCCGTGCGGCAGGGACATTTCCGCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCT
GTGGGTGTCGGGAGCCGGCTGACGGGTGGACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGT
GAGGGAAGAGAGAGAGAGAGAAGGGCGCCTCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTC
CCAGCTGCTAAAGGAAGAGGAAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAAATGACCAGCAGCATGCATTAGTCATGTTAAATGTTTTTGGAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTAT
TCACTTGCCGACCTGCAGCAGACCCAGGCACTACAGCCAAATCTAACCTGATCCACAGATGATTGAAGGATCGGGGGAGCTCGGCACGGG
ATGTGGCAGCAAATGTGCGGCACTAAGGACAAAGTCACTGCCTTTTGTGGAAGCCAGATCAGAAAGATGACTGTGTGTTGTGAGTGGTGG
ATAGAGAGCCCTGTTGCCCAGGTGAGAAGGAGCTCAGTTGAGATAAGGATTCCAGGAGCCAACTCGAGCCCCTCAGGTAGAGACAACAAT
ACCGGTTGAGGCTGCAGCTGTGGAGTTGGATGGTGTTTAGTCAGTGCTGAAATCACTTTCCTGGGAGTCCCTTGGCATGCAGTCATCTGA
GTGCTGTTGTTGTTGTTGGGTTTTTGTTGTTTCCTATTTTAAAAGAGTAATCATAATACTGACGAAGTGAGGGCCTGTTTTCAAAGAACA
TTTACTTAAAGATATAGAGTAAGGTTAGCATCGGTCTTGCCAGTGGTAGAAACCTATGCCACCAACAGCCATCATGAAAGGGCCCCAGGA
GTCTTTCTGGTTCTTCATTTCTATTCAGTTTGATTCAACAAGTGTGTATTGATTGAATGCTTTCTGTGTGCCAATCATTGAGCTAGCCAC
AGAGGAGGCAAAGGTGATTAAGCCACAATTCCTTCCCTCACTGAGCTCACAGTCTGATGAGAGAGGCAGATAGGCATTGTTGAAGTCAGC
GGAGTTGAACCTAGGGTACTTGGGGAATACATCTGACCAAGTGTGTGGCAGATTGTATTTTGCAAAAATAGCTGCAACAGTATCTTCCAT
CCCACATGTCTTTCTTACACTGTGACTTTGATGCTCCTCCTATTCAGTAGTGAGATCTGTGTTCCTTCTCCCCGAATTTGGGCAGGTCTG
TGACTATGGAAGTGATGCCATGTGATTTCCAAAGCCAAGTCATAAAAGGTGATATAGCTCCAACCTGGTGCTGTCTGGAGATGCTCACTC
ATGGCAACCCAGTGGCCATGTTGTAAGGAAGTCCAGATTAGCCCTCATAGAACAACCACATGAACAGGCCTCATATGGTAGTTGTTCTAG
CTGGCAGCGATCATCAGCCACCAGAGAGATGAGTGAAGACAGCCCCACATGATTCCAGCTGCTAGCCTTCAAGTCTTCTCACCTAGGCTA
GAGATGAGGCTGCAGATATTATGGAGCAGAAACAAACCATCTCCACAGTGTCCTTCCTGGAGTCCTGACCGACCGACAAAATGTGTGAGC

>96655_96655_6_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000394417_PLEKHM3_chr2_208795843_ENST00000457206_length(amino acids)=193AA_BP=85
MLKEEEDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQA
KEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENTSFNRSTCIH

--------------------------------------------------------------
>96655_96655_7_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000445915_PLEKHM3_chr2_208795843_ENST00000389247_length(transcript)=811nt_BP=349nt
CTTTTCGTTGAATTGTCATCTGAGCTGCCTTGAGCTGCTGGGTTGACGTTCCAGACGCGTATAATTTATGCTCCTGTACCCTGCTGGGTT
TAGTTTTGCCTCCCTGAAATCAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGGTAATAGAGGGAAAGCTGGCTCC
ATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGGGGTTCATCTGTGAAATCTGTAA
CAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGATTCGGAGACCCATATGCAGATTTATTACAAGGATATGTGGCCTG

>96655_96655_7_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000445915_PLEKHM3_chr2_208795843_ENST00000389247_length(amino acids)=248AA_BP=94
MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP
PEDSVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQ

--------------------------------------------------------------
>96655_96655_8_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000445915_PLEKHM3_chr2_208795843_ENST00000427836_length(transcript)=959nt_BP=349nt
CTTTTCGTTGAATTGTCATCTGAGCTGCCTTGAGCTGCTGGGTTGACGTTCCAGACGCGTATAATTTATGCTCCTGTACCCTGCTGGGTT
TAGTTTTGCCTCCCTGAAATCAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGGTAATAGAGGGAAAGCTGGCTCC
ATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGTAGCCAGAAGGGGTTCATCTGTGAAATCTGTAA
CAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGGTGTGAAAGCTGTGGAGCCGTTTTCCATTCTGAATGCAAAGAAAA
GTCTGTCCCCTGCCCGAGGTGTGTTCGCCGAGAGCTGCAGAAGAAGCAGAAGTCTTTCTGGCAGAGACTGAACATGGACGAGAGTCTAGA

>96655_96655_8_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000445915_PLEKHM3_chr2_208795843_ENST00000427836_length(amino acids)=291AA_BP=94
MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP
PEDSVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQ
VIEGKLAPFLGKVIKFATSHVYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQR

--------------------------------------------------------------
>96655_96655_9_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000445915_PLEKHM3_chr2_208795843_ENST00000457206_length(transcript)=1918nt_BP=349nt
CTTTTCGTTGAATTGTCATCTGAGCTGCCTTGAGCTGCTGGGTTGACGTTCCAGACGCGTATAATTTATGCTCCTGTACCCTGCTGGGTT
TAGTTTTGCCTCCCTGAAATCAGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGA
ATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCG
GAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCGGTGTCGAAGCA
GGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAGAACGCCATGCTGTACCACCACGCAGAGCCGCT
GGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGCTGCCGGGCAGCGGTGGCAGAGGATCTCCGCCG
CAGAAATGACCAGCAGCATGCATTAGTCATGTTAAATGTTTTTGGAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTAT
TCACTTGCCGACCTGCAGCAGACCCAGGCACTACAGCCAAATCTAACCTGATCCACAGATGATTGAAGGATCGGGGGAGCTCGGCACGGG
ATGTGGCAGCAAATGTGCGGCACTAAGGACAAAGTCACTGCCTTTTGTGGAAGCCAGATCAGAAAGATGACTGTGTGTTGTGAGTGGTGG
ATAGAGAGCCCTGTTGCCCAGGTGAGAAGGAGCTCAGTTGAGATAAGGATTCCAGGAGCCAACTCGAGCCCCTCAGGTAGAGACAACAAT
ACCGGTTGAGGCTGCAGCTGTGGAGTTGGATGGTGTTTAGTCAGTGCTGAAATCACTTTCCTGGGAGTCCCTTGGCATGCAGTCATCTGA
GTGCTGTTGTTGTTGTTGGGTTTTTGTTGTTTCCTATTTTAAAAGAGTAATCATAATACTGACGAAGTGAGGGCCTGTTTTCAAAGAACA
TTTACTTAAAGATATAGAGTAAGGTTAGCATCGGTCTTGCCAGTGGTAGAAACCTATGCCACCAACAGCCATCATGAAAGGGCCCCAGGA
GTCTTTCTGGTTCTTCATTTCTATTCAGTTTGATTCAACAAGTGTGTATTGATTGAATGCTTTCTGTGTGCCAATCATTGAGCTAGCCAC
AGAGGAGGCAAAGGTGATTAAGCCACAATTCCTTCCCTCACTGAGCTCACAGTCTGATGAGAGAGGCAGATAGGCATTGTTGAAGTCAGC
GGAGTTGAACCTAGGGTACTTGGGGAATACATCTGACCAAGTGTGTGGCAGATTGTATTTTGCAAAAATAGCTGCAACAGTATCTTCCAT
CCCACATGTCTTTCTTACACTGTGACTTTGATGCTCCTCCTATTCAGTAGTGAGATCTGTGTTCCTTCTCCCCGAATTTGGGCAGGTCTG
TGACTATGGAAGTGATGCCATGTGATTTCCAAAGCCAAGTCATAAAAGGTGATATAGCTCCAACCTGGTGCTGTCTGGAGATGCTCACTC
ATGGCAACCCAGTGGCCATGTTGTAAGGAAGTCCAGATTAGCCCTCATAGAACAACCACATGAACAGGCCTCATATGGTAGTTGTTCTAG
CTGGCAGCGATCATCAGCCACCAGAGAGATGAGTGAAGACAGCCCCACATGATTCCAGCTGCTAGCCTTCAAGTCTTCTCACCTAGGCTA
GAGATGAGGCTGCAGATATTATGGAGCAGAAACAAACCATCTCCACAGTGTCCTTCCTGGAGTCCTGACCGACCGACAAAATGTGTGAGC

>96655_96655_9_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000445915_PLEKHM3_chr2_208795843_ENST00000457206_length(amino acids)=202AA_BP=94
MLLYPAGFSFASLKSDLSKAMSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRP
PEDSVSKQAKEFLEYVYEEPLIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENT

--------------------------------------------------------------
>96655_96655_10_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000467648_PLEKHM3_chr2_208795843_ENST00000389247_length(transcript)=1023nt_BP=561nt
GCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCTGTGGGTGTCGGGAGCCGGCTGACGGGTGG
ACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGTGAGGGAAGAGAGAGAGAGAGAAGGGCGCC
TCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTCCCAGCTGCTAAAGGAAGAGGAAGGTACCT
GTGCGTGCACGCAGACGGGAAGGGCTGGGGAAGCGGGAGGACTGAGAAAAGCCGGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCT
CAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTT
GAGCACACCAAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATC
CAGAGACCCCCTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAG
AACGCCATGCTGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGC
TGCCGGGCAGCGGTGGCAGAGGATCTCCGCCGCAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGAC
CTGCAGCAGGTAATAGAGGGAAAGCTGGCTCCATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGT
AGCCAGAAGGGGTTCATCTGTGAAATCTGTAACAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGATTCGGAGACCCA

>96655_96655_10_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000467648_PLEKHM3_chr2_208795843_ENST00000389247_length(amino acids)=227AA_BP=74
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQAKEFLEYVYEEP
LIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPFLGKVIKFATSH

--------------------------------------------------------------
>96655_96655_11_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000467648_PLEKHM3_chr2_208795843_ENST00000427836_length(transcript)=1171nt_BP=561nt
GCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCTGTGGGTGTCGGGAGCCGGCTGACGGGTGG
ACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGTGAGGGAAGAGAGAGAGAGAGAAGGGCGCC
TCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTCCCAGCTGCTAAAGGAAGAGGAAGGTACCT
GTGCGTGCACGCAGACGGGAAGGGCTGGGGAAGCGGGAGGACTGAGAAAAGCCGGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCT
CAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTT
GAGCACACCAAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATC
CAGAGACCCCCTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAG
AACGCCATGCTGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGC
TGCCGGGCAGCGGTGGCAGAGGATCTCCGCCGCAGAATTTTCCCCAGAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGAC
CTGCAGCAGGTAATAGAGGGAAAGCTGGCTCCATTCTTGGGCAAGGTCATTAAATTTGCCACCTCACACGTGTACAGCTGCAGTCTTTGT
AGCCAGAAGGGGTTCATCTGTGAAATCTGTAACAATGGAGAGATCCTCTACCCTTTTGAGGATATTTCAACAAGCAGGTGTGAAAGCTGT
GGAGCCGTTTTCCATTCTGAATGCAAAGAAAAGTCTGTCCCCTGCCCGAGGTGTGTTCGCCGAGAGCTGCAGAAGAAGCAGAAGTCTTTC
TGGCAGAGACTGAACATGGACGAGAGTCTAGAGGAGGCTTGCACCATGTTCGAGCTGTCCTACCAGAACACCTGACTCCAGCCGACCCGA

>96655_96655_11_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000467648_PLEKHM3_chr2_208795843_ENST00000427836_length(amino acids)=271AA_BP=74
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQAKEFLEYVYEEP
LIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRIFPREYLLQQIHLYSLADLQQVIEGKLAPFLGKVIKFATSH
VYSCSLCSQKGFICEICNNGEILYPFEDISTSRCESCGAVFHSECKEKSVPCPRCVRRELQKKQKSFWQRLNMDESLEEACTMFELSYQN

--------------------------------------------------------------
>96655_96655_12_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000467648_PLEKHM3_chr2_208795843_ENST00000457206_length(transcript)=2130nt_BP=561nt
GCATTGAAGGGGCTGCTCCGAATGGAGGGGGAGGGGAGGTGTTTAGGAGAAAGTAGGGGCTGTGGGTGTCGGGAGCCGGCTGACGGGTGG
ACAAGGGGGGGTTAGCAGCTGGGCTGCGACCGTTAGGGAGGGGCTCAAGGTGTGCATGTGTGAGGGAAGAGAGAGAGAGAGAAGGGCGCC
TCAGAGGTGACTTTCAGCCTGCGAGCCTTCTTCCCGGGGCGCCATAAACGCCCCCAATTTCCCAGCTGCTAAAGGAAGAGGAAGGTACCT
GTGCGTGCACGCAGACGGGAAGGGCTGGGGAAGCGGGAGGACTGAGAAAAGCCGGATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCT
CAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTT
GAGCACACCAAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATC
CAGAGACCCCCTGAAGATTCGGTGTCGAAGCAGGCCAAGGAGTTTCTGGAGTACGTGTACGAAGAGCCGCTCATCGACATCCAGCAGGAG
AACGCCATGCTGTACCACCACGCAGAGCCGCTGGCCGCCGTGCTGCGGCTGCGGCAGCGGCTGAAGTCGCTCCGAGCCTATTTGTTCAGC
TGCCGGGCAGCGGTGGCAGAGGATCTCCGCCGCAGAAATGACCAGCAGCATGCATTAGTCATGTTAAATGTTTTTGGAGAATTTTCCCCA
GAGAATACCTCCTTCAACAGATCCACCTGTATTCACTTGCCGACCTGCAGCAGACCCAGGCACTACAGCCAAATCTAACCTGATCCACAG
ATGATTGAAGGATCGGGGGAGCTCGGCACGGGATGTGGCAGCAAATGTGCGGCACTAAGGACAAAGTCACTGCCTTTTGTGGAAGCCAGA
TCAGAAAGATGACTGTGTGTTGTGAGTGGTGGATAGAGAGCCCTGTTGCCCAGGTGAGAAGGAGCTCAGTTGAGATAAGGATTCCAGGAG
CCAACTCGAGCCCCTCAGGTAGAGACAACAATACCGGTTGAGGCTGCAGCTGTGGAGTTGGATGGTGTTTAGTCAGTGCTGAAATCACTT
TCCTGGGAGTCCCTTGGCATGCAGTCATCTGAGTGCTGTTGTTGTTGTTGGGTTTTTGTTGTTTCCTATTTTAAAAGAGTAATCATAATA
CTGACGAAGTGAGGGCCTGTTTTCAAAGAACATTTACTTAAAGATATAGAGTAAGGTTAGCATCGGTCTTGCCAGTGGTAGAAACCTATG
CCACCAACAGCCATCATGAAAGGGCCCCAGGAGTCTTTCTGGTTCTTCATTTCTATTCAGTTTGATTCAACAAGTGTGTATTGATTGAAT
GCTTTCTGTGTGCCAATCATTGAGCTAGCCACAGAGGAGGCAAAGGTGATTAAGCCACAATTCCTTCCCTCACTGAGCTCACAGTCTGAT
GAGAGAGGCAGATAGGCATTGTTGAAGTCAGCGGAGTTGAACCTAGGGTACTTGGGGAATACATCTGACCAAGTGTGTGGCAGATTGTAT
TTTGCAAAAATAGCTGCAACAGTATCTTCCATCCCACATGTCTTTCTTACACTGTGACTTTGATGCTCCTCCTATTCAGTAGTGAGATCT
GTGTTCCTTCTCCCCGAATTTGGGCAGGTCTGTGACTATGGAAGTGATGCCATGTGATTTCCAAAGCCAAGTCATAAAAGGTGATATAGC
TCCAACCTGGTGCTGTCTGGAGATGCTCACTCATGGCAACCCAGTGGCCATGTTGTAAGGAAGTCCAGATTAGCCCTCATAGAACAACCA
CATGAACAGGCCTCATATGGTAGTTGTTCTAGCTGGCAGCGATCATCAGCCACCAGAGAGATGAGTGAAGACAGCCCCACATGATTCCAG
CTGCTAGCCTTCAAGTCTTCTCACCTAGGCTAGAGATGAGGCTGCAGATATTATGGAGCAGAAACAAACCATCTCCACAGTGTCCTTCCT

>96655_96655_12_UGP2-PLEKHM3_UGP2_chr2_64085070_ENST00000467648_PLEKHM3_chr2_208795843_ENST00000457206_length(amino acids)=182AA_BP=74
MSQDGASQFQEVIRQELELSVKKELEKILTTASSHEFEHTKKDLDGFRKLFHRFLQEKGPSVDWGKIQRPPEDSVSKQAKEFLEYVYEEP
LIDIQQENAMLYHHAEPLAAVLRLRQRLKSLRAYLFSCRAAVAEDLRRRNDQQHALVMLNVFGEFSPENTSFNRSTCIHLPTCSRPRHYS

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Fusion Gene PPI Analysis for UGP2-PLEKHM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UGP2-PLEKHM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UGP2-PLEKHM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource