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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UGT1A7-AGAP1 (FusionGDB2 ID:96666)

Fusion Gene Summary for UGT1A7-AGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: UGT1A7-AGAP1
Fusion gene ID: 96666
HgeneTgene
Gene symbol

UGT1A7

AGAP1

Gene ID

54577

116987

Gene nameUDP glucuronosyltransferase family 1 member A7ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
SynonymsGNT1|UDPGT|UDPGT 1-7|UGT-1A|UGT-1G|UGT1|UGT1-01|UGT1-07|UGT1.1|UGT1.7|UGT1A|UGT1A1|UGT1G|hUG-BR1AGAP-1|CENTG2|GGAP1|cnt-g2
Cytomap

2q37.1

2q37.2

Type of geneprotein-codingprotein-coding
DescriptionUDP-glucuronosyltransferase 1-7Bilirubin-specific UDPGT isozyme 1UDP glucuronosyltransferase 1 family, polypeptide A7UDP glycosyltransferase 1 family, polypeptide A7UDP-glucuronosyltransferase 1 family polypeptide A7sUDP-glucuronosyltransferase 1-1Uarf-GAP with GTPase, ANK repeat and PH domain-containing protein 1Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 1GTP-binding and GTPase-activating protein 1centaurin, gamma 2
Modification date2020031320200313
UniProtAcc.

Q9UPQ3

Ensembl transtripts involved in fusion geneENST00000373426, ENST00000409457, 
ENST00000304032, ENST00000336665, 
ENST00000409538, ENST00000428334, 
Fusion gene scores* DoF score1 X 1 X 1=115 X 15 X 6=1350
# samples 115
** MAII scorelog2(1/1*10)=3.32192809488736log2(15/1350*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UGT1A7 [Title/Abstract] AND AGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGAP1(236403493)-UGT1A7(234675680), # samples:1
UGT1A7(234591438)-AGAP1(236791989), # samples:1
Anticipated loss of major functional domain due to fusion event.AGAP1-UGT1A7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AGAP1-UGT1A7 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUGT1A7

GO:0052695

cellular glucuronidation

17179145

HgeneUGT1A7

GO:0052696

flavonoid glucuronidation

20056724

HgeneUGT1A7

GO:0052697

xenobiotic glucuronidation

20056724


check buttonFusion gene breakpoints across UGT1A7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AGAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IN-8462-11AUGT1A7chr2

234591438

+AGAP1chr2

236791989

+


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Fusion Gene ORF analysis for UGT1A7-AGAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373426ENST00000409457UGT1A7chr2

234591438

+AGAP1chr2

236791989

+
In-frameENST00000373426ENST00000304032UGT1A7chr2

234591438

+AGAP1chr2

236791989

+
In-frameENST00000373426ENST00000336665UGT1A7chr2

234591438

+AGAP1chr2

236791989

+
In-frameENST00000373426ENST00000409538UGT1A7chr2

234591438

+AGAP1chr2

236791989

+
In-frameENST00000373426ENST00000428334UGT1A7chr2

234591438

+AGAP1chr2

236791989

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000373426UGT1A7chr2234591438+ENST00000336665AGAP1chr2236791989+465285502219739
ENST00000373426UGT1A7chr2234591438+ENST00000304032AGAP1chr2236791989+1005785502378792
ENST00000373426UGT1A7chr2234591438+ENST00000409538AGAP1chr2236791989+465285502219739
ENST00000373426UGT1A7chr2234591438+ENST00000428334AGAP1chr2236791989+293285502378792

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373426ENST00000336665UGT1A7chr2234591438+AGAP1chr2236791989+0.0032158290.9967842
ENST00000373426ENST00000304032UGT1A7chr2234591438+AGAP1chr2236791989+0.0022284430.99777156
ENST00000373426ENST00000409538UGT1A7chr2234591438+AGAP1chr2236791989+0.0032158290.9967842
ENST00000373426ENST00000428334UGT1A7chr2234591438+AGAP1chr2236791989+0.0125631140.9874369

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Fusion Genomic Features for UGT1A7-AGAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
UGT1A7chr2234591438+AGAP1chr2236791988+8.21E-050.99991786
UGT1A7chr2234591438+AGAP1chr2236791988+8.21E-050.99991786

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for UGT1A7-AGAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:236403493/chr2:234675680)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AGAP1

Q9UPQ3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system. {ECO:0000269|PubMed:12640130}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAGAP1chr2:234591438chr2:236791989ENST00000304032818609_729350858.0DomainArf-GAP
TgeneAGAP1chr2:234591438chr2:236791989ENST00000336665817609_729350805.0DomainArf-GAP
TgeneAGAP1chr2:234591438chr2:236791989ENST00000409457010346_5880406.0DomainPH
TgeneAGAP1chr2:234591438chr2:236791989ENST00000409457010609_7290406.0DomainArf-GAP
TgeneAGAP1chr2:234591438chr2:236791989ENST00000409457010122_1260406.0Nucleotide bindingGTP
TgeneAGAP1chr2:234591438chr2:236791989ENST00000409457010178_1810406.0Nucleotide bindingGTP
TgeneAGAP1chr2:234591438chr2:236791989ENST0000040945701078_850406.0Nucleotide bindingGTP
TgeneAGAP1chr2:234591438chr2:236791989ENST0000040945701066_2760406.0RegionNote=Small GTPase-like
TgeneAGAP1chr2:234591438chr2:236791989ENST00000304032818768_797350858.0RepeatNote=ANK 1
TgeneAGAP1chr2:234591438chr2:236791989ENST00000304032818801_830350858.0RepeatNote=ANK 2
TgeneAGAP1chr2:234591438chr2:236791989ENST00000336665817768_797350805.0RepeatNote=ANK 1
TgeneAGAP1chr2:234591438chr2:236791989ENST00000336665817801_830350805.0RepeatNote=ANK 2
TgeneAGAP1chr2:234591438chr2:236791989ENST00000409457010768_7970406.0RepeatNote=ANK 1
TgeneAGAP1chr2:234591438chr2:236791989ENST00000409457010801_8300406.0RepeatNote=ANK 2
TgeneAGAP1chr2:234591438chr2:236791989ENST00000304032818624_647350858.0Zinc fingerC4-type
TgeneAGAP1chr2:234591438chr2:236791989ENST00000336665817624_647350805.0Zinc fingerC4-type
TgeneAGAP1chr2:234591438chr2:236791989ENST00000409457010624_6470406.0Zinc fingerC4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUGT1A7chr2:234591438chr2:236791989ENST00000373426+15488_504285531.0TransmembraneHelical
TgeneAGAP1chr2:234591438chr2:236791989ENST00000304032818346_588350858.0DomainPH
TgeneAGAP1chr2:234591438chr2:236791989ENST00000336665817346_588350805.0DomainPH
TgeneAGAP1chr2:234591438chr2:236791989ENST00000304032818122_126350858.0Nucleotide bindingGTP
TgeneAGAP1chr2:234591438chr2:236791989ENST00000304032818178_181350858.0Nucleotide bindingGTP
TgeneAGAP1chr2:234591438chr2:236791989ENST0000030403281878_85350858.0Nucleotide bindingGTP
TgeneAGAP1chr2:234591438chr2:236791989ENST00000336665817122_126350805.0Nucleotide bindingGTP
TgeneAGAP1chr2:234591438chr2:236791989ENST00000336665817178_181350805.0Nucleotide bindingGTP
TgeneAGAP1chr2:234591438chr2:236791989ENST0000033666581778_85350805.0Nucleotide bindingGTP
TgeneAGAP1chr2:234591438chr2:236791989ENST0000030403281866_276350858.0RegionNote=Small GTPase-like
TgeneAGAP1chr2:234591438chr2:236791989ENST0000033666581766_276350805.0RegionNote=Small GTPase-like


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Fusion Gene Sequence for UGT1A7-AGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96666_96666_1_UGT1A7-AGAP1_UGT1A7_chr2_234591438_ENST00000373426_AGAP1_chr2_236791989_ENST00000304032_length(transcript)=10057nt_BP=855nt
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGTGGCTTTGCCAAGGCAGGGAAGCTGCTGGTA
GTGCCCATGGATGGGAGCCACTGGTTCACCATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCATACACTCTGGAGGATCAGGACCGGGAGTTC
ATGGTTTTTGCCGATGCTCGCTGGACGGCACCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGTTGTTTTGATGCAGTGTTTCTCGATCCTTTT
GATGCCTGTGGCTTAATTGTTGCCAAATATTTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCCATGACTTTCAAGGAGAGAGTATGGAACCAC
ATCATGCACTTGGAGGAACATTTATTTTGCCCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAGTATCCCAAACCCGTGATGCCCAATATGATC
TTCATTGGTGGTATCAACTGTCATCAGGGAAAGCCAGTGCCTATGGGCATGCTGTTGAAGCGAAGTGGCAAATCGTTGAATAAAGAGTGG
AAAAAGAAATATGTCACCCTGTGTGACAATGGCGTGCTGACCTATCATCCCAGTTTACATGATTACATGCAGAATGTTCATGGTAAGGAG
ATTGACCTTCTGAGAACCACTGTGAAAGTCCCAGGGAAGAGGCCACCCCGAGCCACGTCAGCCTGCGCACCCATCTCCAGCCCTAAAACC
AATGGCCTATCCAAGGACATGAGCAGTTTACACATCTCACCCAATTCAGGGAATGTCACTAGTGCATCTGGGTCTCAGATGGCAAGCGGC
ATCAGCCTGGTCTCCTTCAACAGCCGACCCGACGGCATGCACCAGCGCTCCTACTCAGTCTCCAGTGCCGACCAGTGGAGTGAGGCTACG
GTCATTGCAAACTCGGCCATCAGCAGTGACACAGGGCTGGGTGACTCCGTATGCTCCAGCCCCAGTATCTCCAGCACCACCAGCCCCAAG
CTCGACCCGCCCCCCTCCCCTCACGCCAACAGAAAGAAGCACCGAAGGAAGAAAAGCACTAGCAACTTCAAAGCCGACGGCCTGTCCGGC
ACTGCTGAAGAACAAGAAGAAAATTTTGAGTTTATCATTGTGTCCCTCACTGGCCAAACATGGCACTTTGAAGCCACGACGTATGAGGAG
CGGGACGCCTGGGTCCAAGCCATCGAGAGCCAGATCCTGGCCAGCCTGCAGTCGTGCGAGAGCAGCAAGAACAAGTCCCGGCTGACGAGC
CAGAGCGAGGCCATGGCCCTGCAGTCGATCCGGAACATGCGCGGGAACTCCCACTGTGTGGACTGCGAGACCCAGAATCCCAACTGGGCC
AGTTTGAACTTGGGAGCCCTCATGTGCATCGAATGCTCAGGGATCCACCGGAATCTTGGCACCCACCTTTCCCGAGTCCGATCTCTGGAC
CTGGATGACTGGCCAGTCGAGCTCATCAAGGTGATGTCATCCATCGGGAACGAGCTAGCCAACAGCGTCTGGGAAGAGAGCAGCCAGGGG
CGGACGAAACCATCGGTAGACTCCACAAGGGAAGAGAAGGAACGGTGGATCCGTGCCAAGTACGAGCAGAAGCTCTTCCTGGCCCCGCTG
CCCTGCACGGAGCTGTCCCTGGGCCAGCACCTGCTGCGGGCCACCGCCGACGAGGACCTGCGGACGGCCATCCTGCTGCTGGCACACGGC
TCCCGGGACGAGGTGAACGAGACCTGCGGGGAGGGAGACGGCCGCACGGCGCTGCATCTGGCCTGCCGCAAGGGGAATGTGGTCCTGGCG
CAGCTCCTGATCTGGTACGGAGTGGACGTCACGGCCCGAGATGCCCACGGGAACACAGCTCTGGCCTACGCCCGGCAGGCCTCCAGCCAG
GAGTGCATCGACGTGCTGCTGCAGTACGGCTGCCCCGACGAGCGCTTCGTGCTCATGGCCACCCCTAACCTGTCCAGGAGAAACAATAAC
CGGAACAACAGCAGTGGGAGGGTGCCCACCATCATCTGAGGAACAGCCGTGCCCGCCTGCTCGCCGCACCTGGGACGCGGCAGCCTCGCC
GCATTCTCGCTCAGAAGTCGCAGCACGTGAGTCCCGTCGCATCCCCTCCCTCTTCCTGGTGGCCACCTCCCTCCCGCCCACCCACTCTCA
CCCCAAACAAAATCACAAAACCTGGACATCCCTCAAGGGGCGAAGAGGCGGCCGGGAGACTGCAGAAGTGGCTCCTTTTCATAAACTCCC
CTAAACCACACACAGGAGAGAGCGACGGGCCTCGGCCCTTTGATGATAGCACATGGCGCAGGACCCTTGTCCTGGTGGCACAAGGGATGG
GGACGCGAGGGGGAGGGGAGGCGAGGAACAAGGAGAAGGGGCAACTTTCCTTAACTGGCAGTTGAGCACATAGTACATTTCCCCTCTACC
AAACGGAACACTTGGATTCCATCTCTTCTCTGAGGAGCTCGACGGCATAAATCAGAAGCAAGCACAGAGTTTGTCAGGTTTGAAGCCCCT
ATGATGGTGTGTGTCAAATCAGTTGTAGCTAATCTGTCCAGGGAGAATACTGGCTTCATTACACTTGTACAGCCGAGTTCTTCCCGCATT
ACTGCTGTTTAATAGAACGTGATTAGTCATCGCCGAGAAGAAAGCATATTAGCCGAGGAGGTAGTCACGCGGCACGCGCCGGTGATTGCC
ACGATGTGATTGCAATACTCTTAGAAGCACCATATTATCCCAGACATGTTCTTTCAAGCCCTTGGAGCCCTCTCTAAATTCACTGTCATC
ATTTAGTATCTGTTTAATTTTTCAGTCCAAAGAGAGGAAATCAGTCGCTGAGTATTATTTGACTCCGGTCTCCTTGGTGCAAAAACAAAA
TGGGAAAAATAAATAAGAATAACTCAGAAACTCAAAAGGAAACCACAAATTCAGCTAATAATAGCATTTCGAGTATATTTCGTAAACTAA
GGAAATACACAAAAGGCTGTTTTTTCCGACTGTAAGAGATATTTGATGTCCTTTTGCCGAGGTGGATGTGTTAGTCTCAGGCCCTCCTGG
ACCACGTTGCCCAAGTCACACAGGCTTCTGTGTTATGTATTTAGATAAGATGTGTGAAAATATATTTGAATAAAAGAAGTTCATAAATAT
GCATTGATTTTTGTACAGACAAATGGCACCTCTCTTAATTTATAAATTGAACTGGATGTGAACTAATAATGTGCAACTAGTTGAGATAAG
AGGGTTACAGATCATTGTACATGGAAAATATTCCCAGCAGTAAACACTTCCATTAATGTGATCTACGGCTTTTGAAAAGGAGCATCTCAG
AATAAGATGGTGGTACAATTTGCTTATTAAAATTGAGAAAGAAAAAAAAAGACACACTGGAGTATATTAGAAAGGAAAAAGAAGGAATGT
GGTCTCTCATGATTGAAAGCATGATTTAGATCGGATACGGCTTTTGCTAACCAAGGACCAAGGGACTCTGGCAAGATGGGGTGGTTTTCC
GAATGCCAGACCGAGGTGCCTTACGAAGGCAGCTGCCAATGGTTCTGTGGCACAGACTGGCTCCTGAGAACCCAGACGACCTTGACCTGG
CAGCCCGGCCCTCCACGCTAGTACCTCGCCTGATTTTCCATCGTTGCGGTATCCAGCCGCTTCAGACGTCCGCCGCCTTCAGTGGTGGTA
GTCAAATGTAGTCAACCAAACCACAGCATCCCTTAGGTTAAAAGCAAACGGGGCAGCTTTGCCTAGAGCTCATTGACAGTGTGATGGGGG
GAGAAGGGTTGTCACAATGGAAGATGAGGACACTAGACTCATGTAGCACAGAAACATGAAGCCACACGCACCGGCAGCCTCCGGGGTGTT
CCTCGCTCTCTCGTATGTTAAACCTTATATTTTATAAGAGTTTTTCCTCTTATTTCACTTTTTAAAAAAAATTAAAGTAGGTGGGGAAAA
AAATAAAGCTTTACACAGAATTTATATGTGGGTAAGTGTTTCATGGAAATTTCTAATCTTAACGAAGCTAAGTGGAGCTCACTCGTATCC
AAAAGTATAACAGGTGCAGAAGCCACAAGTCTGAGAACCTTGACGACAGTTCCATCGTCCTGCCATTTGATTTTTCAGTCTGCGTTTCAT
CACTGTGTAGCTATTGTAAATGTGAATAGAAAAAAACAGGTCATTGCCTATTTTTGAAGAACGCGTTGGTGTTCGAGTCCACTAGACACA
CTCGCTCCACACAGCCTTCACCGTAGACTCTGTAGTGGACACAGATATAGCATAAATGAAATTGTTAAATTATTTCATTGTAGTTAATTC
CCACTATAGGAATGCTTTATCATAGTGAAGTTTCTTTTGAGAAGAAACGGAACTCCTTGAGGCTTCTCTTTGGGATGTATATGAGCGTGT
ACATATTATTCTATGTGTTTATAATATAATATTTTCCCAAATGACTTCTTGTTTCACTTTGCCTTCCACAACCTGAATGCCAGATTGGTT
TTTTCCCTTCCTGGCCCCCAGCACAAGCTGCCATGACTCCCCCTCAGAAAACACAGCCCCTCCTCTACCATTCTCAGTGATGTCCATCTG
CTCCACTCCGCAGCCACTTTCTAGGGCCCAAGTTTTGGTAGCAGAAGGAAAGGCAGTTTTTGAGGGTCTTTCGAAAAAAAGAAGACGGGG
CAGCTTTGCCCAGAGCTCGTTGGCAGTCTGTTTGTATTTCAGTGTCTAACCAGAAGTCCTTTCTTTGCGGACCGCACTCTCGTTCCCACT
TTCAAGCTAATTACCACCAAGGCTGGGAGAGGCAAGGACTGGGGGCGGAGCTAGGAATAACTCGTTTGAGAAGGGGGTGGAGTTTTCGTT
GTTCATTTCCATGTTCAGTTCTGTGACGTGACGATGACAGATCACCACTGCAGGATCCCCCTCACCTTTCCTGTTCAGAATTAAAACTCT
CCCTTGATGAGAAACAGCCAGCTGAGGGAGGCCCACGAGCGGCCTGTGTAACCCCATGGGTGATCTGGACACATCTGCACCCCCGCGTTC
AGCTTCGCGGAGACTGAACTTGGCGGGGAGTGGAGGGGTGTGGTGCAGACCTGGCTGCAGCAGAAACACCCCGCAGGGACAGTACTCTGT
GATTCTGACCTCAGGTGCTGGGACGGGCAGATGGTTTCCCCCGCCCAGCACCCCAGTCCTGGTCCCTGGTCCCTCTCTCTGTTTCATCCC
AGGAAATGAGCAGCTCGAGGGTGAGCAAGTGACAAGTTCCTGAGTCACTGGCCCCAAAACCAGGTGCAGTGTCCTGTCTCCCAAGTGTGT
GCACAATGTATATATGCACTGGAAAGGAGGGAGAAGGCAGCGGGTCACTCGCCAATCGCAGGGTTCTCAGACACAGGAGAGAGCGGGATC
TTAATGAATTGCATTTCCTGCAGAGCCTCTAGTGCACAGGCCAGTTCTCGGCAGTGGCTTTTCAGCACAAGGGCCTTGCATTGAAGCTCC
CTCTTCTGAGATTTCACCCAGCCTGATGAGGCCTGCATGGTTCCGGCCTCGTCATCCAGTGTAGATACCAGTCTTCCTATTTTTGTGACA
TCTGCACATTTGGGGTCATTCCCTATATCTGCATAGGAGCTATTGCTAACCTTGTTAGGGAGAAACATGGTCTAATGAGAAAGACAGACC
CCTAGGCTCAGCTGGCCCTGCCATCCTTCCAGAGGATTCCTCTGCAACTCTAGGCAAGCACCCAGCTTCCTGGGCTCTTTTTCCTCATCT
GTGAAACTTGCAGGGTGCAGTGAGGTTTCAAACCAGTGTGATAAGTGTTGGCCTCACACCTGGCCCAGGGGATGCTGGGAGAACAGGAGC
ACTTGTTAATAACAGAAACACTGATGGGACCGAAGCCAGTGCACACACCAGGAAACCTGCCCGTGGCTGACACTGTCCTCCAGCCTGCAT
TCTGGGGAGGCTGTGATGGGCACGTTTGCCAACCCCCCCCCCCCAGTAGAGCCCAGGACCCTCCTCTCTCAGCTTGCCAGTGCCCTGCCC
TCCACATGGCGGGGAACAGCATCAATGAGGTCCTTGCTCCCTGAGAGCCTCTCTGGAACCTGCCCACTTTTCTCAACATGTATATTCTGC
TTTGTAGTCTGAGGTTGATTTTCTAGAGGCGAGGAAGGGGCTGAGTTCTGCCCTCGTGCTGTTCGCTGGTGCTGATCAGGGCCAAGACGA
CCCTTCCCTCTCCCCCACAGCCTGTTGAGGTGCCGTTGACGTGGACAGCGCCCCTCCCTTAAGATGCCCCCTTGCCGTTGCCATGAGCCG
CTGTGACTCACGCGTGCACTGGGCCTTGCTTGGTGCTCCCCTCCTCCTCCTGTCTGAGATCGGAGCTTGCTGGAGAGCACCCCAGGTCGC
CGTGCTTGGCTGCAGGCCCGTCCCTCTCTCCCCATCCTCGGGTTCCCAGCGTGTTTTGTGCTTGAACTTGGTGGACTCATCTTACCCCAC
AAGAGTGGCCTGCTCAACCTGCAGCCTCCAATGTGCCGTAGGCGCTCTAGGTCCCCGTGGCGCCCAGGACACCAACTCTCCCTCCCTGCA
CTTAGGATGTTCTGGAAATGAGAGGAAATCCACATTCCTGCCCCAGGAGGTGGGAAGCCTGGCAACGATGTAGCTTCCCCTGAGATGCGG
TATGATCAGGCCTCAGCAACTACTCAGGAGGCAAAGGTGTTTGGAAAGCAAACCCCAAACCTCCCGGCACGGCATGTGCTCTGCTTCCGT
CCCTCACCGCCTGCACAAGGTCGTTGAGACTTTTCTAGAACTCCCCGGGGTTGTATTTATGGCCTTCAAGCAAACAAATTGAAAAGCAGT
CAAGGAGGAGTTCAGATAGAAAAGTGCTGGAGATACACATCTTTCCTTCAAAGGAAATGTAATTTATTTCCAACCGCTGCCTCAGACGGG
GGTTTCACATGTTGTGAAGTCACATCTTGAATGACTGTCACCCTCATCCTTCCCCAAAAAGCTAAATAAGGGCCTTTGGCATCAATGCGT
GCATTCTCCACCTTTCCGCGGCTTGCGCTTGGATTTCTGAGTGGCTTTCTTCAGGGAGCCCTTGTGGTCATGTGTCTTTAATGCTGCTCC
CCATGCCCCCAGGCCAGGCCAGCACGCTCAGGTGATAGCGAGTGGGGCCAGGAGACCCCCCTGCCCTGCCCAGTGGACAGATCTGCCCCA
GCCCTGCTGTGGGGACGGGCCCTCTATCATTTAACCACATACATTAGGTTGCTTTTCAGCAAAATGTCAGCTTTCCTCCCATTATGCAGG
AGAGAGAAGGGGCGCAGGTGTATCTCCTTAGAGTACACCTTGGAGCTGGATCACTAAGAAACAGTCCTCAGACTGGTCCTTCCGACACAG
GCAGAGAGTGAACTGGATCGCTGGCCCCTGGGATGCTGCGCTGTCTGTGATTAGAGAGAAGTGGCCAGTGTCCCGTCTGTGATTAGACAG
AAACCCCTGTGGCAGACTCCTCCCCTCTCCATGAAGAAAGAAATATTTACTTAGATATTACTGTTTCAAAACACAAACTTTATTCCCCTT
AGAGAAGAAATACTGCCCTTAAATAGACTGTTGAAATATTAATGGCCCCCCCATTTAATCAGTGTGTCTGCGGCTTTCTTCGCGTCACAT
GTCCGCATTGGCAGGTGATTCTGGAAAGGGATTCTGGGAAACCAACAAGTCTTTTTTAAATCTTTGAGTTGTATGAGAAAGTATTTAAGT
TCACCAGTGTAGTAAACACCCACCCCAGAGCAGCGGTAAGCAAACCTAAATCTGAAAACCCATTCTTACTGTCTTTCACCATGAGATGCT
GGTTTTGGTGTAAAATGACAGCACTTGGTTTGGGGTTTTGCACCTGTTGGGTAGAACTGTTCTTGTCTGAGGTCCTCACCCTCTACAGAT
GGGCCTCAGGGCCTGGAGGTGGGCAGATGGGGCCAGAGTGGCCAGCAGAGACTTGCATGGGCTCTGAAAGCCCCAGAGCTCAGGCCTAAG
GCTGCTAGGTGAGACCAGCAGGCAGCTGTGGCATCCGACCTTGGGACGCCCAAGCTGGGCAGCCGCTCCATGTGCCCCAAACAGGATATC
CTCATGAATGTGAGGAGAGGCTGGCTCAGGGCTTGGTTTTCATTTTGGCCTGGCACAGGGTACCTGTAGGGAGCACTCCCCCAACCTGAG
GATGGTGAAACCATATGATAGAGACTCCTTGTCGAAGTCCACATCGGACTGATCTAGAATGCCCCGTGGGGGGATTGCATGGCCTTTGCC
TTGAGATGCAGGTGAAAGAAAGGAACCAAACAAGGCATGAGTGTGTTGGGGAATCTTCCCAGTGGAGCAAACCCCCTTAACACACCAGCT
GTTGGGAACAGCTGCCCCTAAATCCAATTAAACCCTCATCTCCCTGGTGCTGAACAGTCTACACTGGCCCAGGAAGCTAACGTCTGAGCC
GCTTGGAGAGCTTTGGTAAACAGAAGACACTGGAAGCCCACTCGGTCAGCAGCTGGGCATGAGGATGTCAGGGGCCTTTGGACTTGAGGA
AGGACAGTCCAGGTGCATGGAATCCTAATGGGCCTCATGCAGACACTGGAAGCAGCCCAGCCCCCTGCCCAATACCACAGCCCTGGGGTG
TCCCCTGACATTCCTGGAGGTCCCTGGGCAAATGCATTTCCTGCCTGGGTTCTCAGGGTAGGAGAACAGAGAAGGCTCCAAGGGTGTTGG
GAGTGAGCCAGGGGCTGGTCTGGGGAGTGGGTCTCACGCACTGCTCAGGTTGGCACGAGGGACCTCCCCCATCCCAACCCAGCCCCAAGG
GTCCCAGCAGGGCTCTCAGCATGGCTGTTTTGAGGGTACACAGGTGGCTGGAGAGGGGTGGGGCAGTTGCATGGTGGGTGGCAAAGTGTG
CATTTAGAAGCTGCTTCGTGGCGTTAAGAACGGGGGGAGAGGGACCAGCACTGTAACGTTAGAAATAATTCCTTCTTGCAGACTTGAAAA
GCATCAGTTTCCCTCCCACGGCTGGGTTTTTGTGTCTGAAATACATCTAATTCTCCAGACTGCAGCCCCTCTCAGCCCCGAGCACCTGAG
CGCTGGGGAGGCCCTTATTGAGCTCAGCCTGGAGAGGGGAGGGTCGCACGGGTCCCGGGGGCAGGTCTCCTGCACTGGCTCTTCCCTTCT
GCCAGCTTGGAATTTGGTTCTCATCTTGCCACAGGGGTGCGTTTCCTAAAGGGCAGCCGGAGCAGCTCAAAGGTGACAACTGAGATGCAT
TTCTAGGCAGGGGCAGGGAAGGCCAACCCACCTTGCAGCCAGTTTTCTGTTTCTGTAAATAGCAGTGTATAGAGATGGAAGGGCAGCGTG
GGTGTATCCACAGATGGGTTTAGGTTTTTTTTTTGGATGTTTTCTATTACCTCATTCAGCAACTTTATGTTTCACAATGACTCAATGATG
CTTTATTTATATTGTTTGTACTGTAATTAAAACCATTGACAGACATTTCACTTTGCTTGTTATTTCATATGATCTTGTTTTGATTAAATA
TGCCAGTTTGTATTTTCCTGCCTTGGGATTTTTTTGTGTCCGCTGTACAGTATTCTAAGGGAAAAAGAAAAAGAAAGATGTGTAAAGTAA

>96666_96666_1_UGT1A7-AGAP1_UGT1A7_chr2_234591438_ENST00000373426_AGAP1_chr2_236791989_ENST00000304032_length(amino acids)=792AA_BP=285
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREF
MVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMI
FIGGINCHQGKPVPMGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKT
NGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSAISSDTGLGDSVCSSPSISSTTSPK
LDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTS
QSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQG
RTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLA

--------------------------------------------------------------
>96666_96666_2_UGT1A7-AGAP1_UGT1A7_chr2_234591438_ENST00000373426_AGAP1_chr2_236791989_ENST00000336665_length(transcript)=4652nt_BP=855nt
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGTGGCTTTGCCAAGGCAGGGAAGCTGCTGGTA
GTGCCCATGGATGGGAGCCACTGGTTCACCATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCATACACTCTGGAGGATCAGGACCGGGAGTTC
ATGGTTTTTGCCGATGCTCGCTGGACGGCACCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGTTGTTTTGATGCAGTGTTTCTCGATCCTTTT
GATGCCTGTGGCTTAATTGTTGCCAAATATTTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCCATGACTTTCAAGGAGAGAGTATGGAACCAC
ATCATGCACTTGGAGGAACATTTATTTTGCCCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAGTATCCCAAACCCGTGATGCCCAATATGATC
TTCATTGGTGGTATCAACTGTCATCAGGGAAAGCCAGTGCCTATGGGCATGCTGTTGAAGCGAAGTGGCAAATCGTTGAATAAAGAGTGG
AAAAAGAAATATGTCACCCTGTGTGACAATGGCGTGCTGACCTATCATCCCAGTTTACATGATTACATGCAGAATGTTCATGGTAAGGAG
ATTGACCTTCTGAGAACCACTGTGAAAGTCCCAGGGAAGAGGCCACCCCGAGCCACGTCAGCCTGCGCACCCATCTCCAGCCCTAAAACC
AATGGCCTATCCAAGGACATGAGCAGTTTACACATCTCACCCAATTCAGACACAGGGCTGGGTGACTCCGTATGCTCCAGCCCCAGTATC
TCCAGCACCACCAGCCCCAAGCTCGACCCGCCCCCCTCCCCTCACGCCAACAGAAAGAAGCACCGAAGGAAGAAAAGCACTAGCAACTTC
AAAGCCGACGGCCTGTCCGGCACTGCTGAAGAACAAGAAGAAAATTTTGAGTTTATCATTGTGTCCCTCACTGGCCAAACATGGCACTTT
GAAGCCACGACGTATGAGGAGCGGGACGCCTGGGTCCAAGCCATCGAGAGCCAGATCCTGGCCAGCCTGCAGTCGTGCGAGAGCAGCAAG
AACAAGTCCCGGCTGACGAGCCAGAGCGAGGCCATGGCCCTGCAGTCGATCCGGAACATGCGCGGGAACTCCCACTGTGTGGACTGCGAG
ACCCAGAATCCCAACTGGGCCAGTTTGAACTTGGGAGCCCTCATGTGCATCGAATGCTCAGGGATCCACCGGAATCTTGGCACCCACCTT
TCCCGAGTCCGATCTCTGGACCTGGATGACTGGCCAGTCGAGCTCATCAAGGTGATGTCATCCATCGGGAACGAGCTAGCCAACAGCGTC
TGGGAAGAGAGCAGCCAGGGGCGGACGAAACCATCGGTAGACTCCACAAGGGAAGAGAAGGAACGGTGGATCCGTGCCAAGTACGAGCAG
AAGCTCTTCCTGGCCCCGCTGCCCTGCACGGAGCTGTCCCTGGGCCAGCACCTGCTGCGGGCCACCGCCGACGAGGACCTGCGGACGGCC
ATCCTGCTGCTGGCACACGGCTCCCGGGACGAGGTGAACGAGACCTGCGGGGAGGGAGACGGCCGCACGGCGCTGCATCTGGCCTGCCGC
AAGGGGAATGTGGTCCTGGCGCAGCTCCTGATCTGGTACGGAGTGGACGTCACGGCCCGAGATGCCCACGGGAACACAGCTCTGGCCTAC
GCCCGGCAGGCCTCCAGCCAGGAGTGCATCGACGTGCTGCTGCAGTACGGCTGCCCCGACGAGCGCTTCGTGCTCATGGCCACCCCTAAC
CTGTCCAGGAGAAACAATAACCGGAACAACAGCAGTGGGAGGGTGCCCACCATCATCTGAGGAACAGCCGTGCCCGCCTGCTCGCCGCAC
CTGGGACGCGGCAGCCTCGCCGCATTCTCGCTCAGAAGTCGCAGCACGTGAGTCCCGTCGCATCCCCTCCCTCTTCCTGGTGGCCACCTC
CCTCCCGCCCACCCACTCTCACCCCAAACAAAATCACAAAACCTGGACATCCCTCAAGGGGCGAAGAGGCGGCCGGGAGACTGCAGAAGT
GGCTCCTTTTCATAAACTCCCCTAAACCACACACAGGAGAGAGCGACGGGCCTCGGCCCTTTGATGATAGCACATGGCGCAGGACCCTTG
TCCTGGTGGCACAAGGGATGGGGACGCGAGGGGGAGGGGAGGCGAGGAACAAGGAGAAGGGGCAACTTTCCTTAACTGGCAGTTGAGCAC
ATAGTACATTTCCCCTCTACCAAACGGAACACTTGGATTCCATCTCTTCTCTGAGGAGCTCGACGGCATAAATCAGAAGCAAGCACAGAG
TTTGTCAGGTTTGAAGCCCCTATGATGGTGTGTGTCAAATCAGTTGTAGCTAATCTGTCCAGGGAGAATACTGGCTTCATTACACTTGTA
CAGCCGAGTTCTTCCCGCATTACTGCTGTTTAATAGAACGTGATTAGTCATCGCCGAGAAGAAAGCATATTAGCCGAGGAGGTAGTCACG
CGGCACGCGCCGGTGATTGCCACGATGTGATTGCAATACTCTTAGAAGCACCATATTATCCCAGACATGTTCTTTCAAGCCCTTGGAGCC
CTCTCTAAATTCACTGTCATCATTTAGTATCTGTTTAATTTTTCAGTCCAAAGAGAGGAAATCAGTCGCTGAGTATTATTTGACTCCGGT
CTCCTTGGTGCAAAAACAAAATGGGAAAAATAAATAAGAATAACTCAGAAACTCAAAAGGAAACCACAAATTCAGCTAATAATAGCATTT
CGAGTATATTTCGTAAACTAAGGAAATACACAAAAGGCTGTTTTTTCCGACTGTAAGAGATATTTGATGTCCTTTTGCCGAGGTGGATGT
GTTAGTCTCAGGCCCTCCTGGACCACGTTGCCCAAGTCACACAGGCTTCTGTGTTATGTATTTAGATAAGATGTGTGAAAATATATTTGA
ATAAAAGAAGTTCATAAATATGCATTGATTTTTGTACAGACAAATGGCACCTCTCTTAATTTATAAATTGAACTGGATGTGAACTAATAA
TGTGCAACTAGTTGAGATAAGAGGGTTACAGATCATTGTACATGGAAAATATTCCCAGCAGTAAACACTTCCATTAATGTGATCTACGGC
TTTTGAAAAGGAGCATCTCAGAATAAGATGGTGGTACAATTTGCTTATTAAAATTGAGAAAGAAAAAAAAAGACACACTGGAGTATATTA
GAAAGGAAAAAGAAGGAATGTGGTCTCTCATGATTGAAAGCATGATTTAGATCGGATACGGCTTTTGCTAACCAAGGACCAAGGGACTCT
GGCAAGATGGGGTGGTTTTCCGAATGCCAGACCGAGGTGCCTTACGAAGGCAGCTGCCAATGGTTCTGTGGCACAGACTGGCTCCTGAGA
ACCCAGACGACCTTGACCTGGCAGCCCGGCCCTCCACGCTAGTACCTCGCCTGATTTTCCATCGTTGCGGTATCCAGCCGCTTCAGACGT
CCGCCGCCTTCAGTGGTGGTAGTCAAATGTAGTCAACCAAACCACAGCATCCCTTAGGTTAAAAGCAAACGGGGCAGCTTTGCCTAGAGC
TCATTGACAGTGTGATGGGGGGAGAAGGGTTGTCACAATGGAAGATGAGGACACTAGACTCATGTAGCACAGAAACATGAAGCCACACGC
ACCGGCAGCCTCCGGGGTGTTCCTCGCTCTCTCGTATGTTAAACCTTATATTTTATAAGAGTTTTTCCTCTTATTTCACTTTTTAAAAAA
AATTAAAGTAGGTGGGGAAAAAAATAAAGCTTTACACAGAATTTATATGTGGGTAAGTGTTTCATGGAAATTTCTAATCTTAACGAAGCT
AAGTGGAGCTCACTCGTATCCAAAAGTATAACAGGTGCAGAAGCCACAAGTCTGAGAACCTTGACGACAGTTCCATCGTCCTGCCATTTG
ATTTTTCAGTCTGCGTTTCATCACTGTGTAGCTATTGTAAATGTGAATAGAAAAAAACAGGTCATTGCCTATTTTTGAAGAACGCGTTGG
TGTTCGAGTCCACTAGACACACTCGCTCCACACAGCCTTCACCGTAGACTCTGTAGTGGACACAGATATAGCATAAATGAAATTGTTAAA
TTATTTCATTGTAGTTAATTCCCACTATAGGAATGCTTTATCATAGTGAAGTTTCTTTTGAGAAGAAACGGAACTCCTTGAGGCTTCTCT

>96666_96666_2_UGT1A7-AGAP1_UGT1A7_chr2_234591438_ENST00000373426_AGAP1_chr2_236791989_ENST00000336665_length(amino acids)=739AA_BP=285
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREF
MVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMI
FIGGINCHQGKPVPMGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKT
NGLSKDMSSLHISPNSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTWHF
EATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHL
SRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTA
ILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPN

--------------------------------------------------------------
>96666_96666_3_UGT1A7-AGAP1_UGT1A7_chr2_234591438_ENST00000373426_AGAP1_chr2_236791989_ENST00000409538_length(transcript)=4652nt_BP=855nt
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGTGGCTTTGCCAAGGCAGGGAAGCTGCTGGTA
GTGCCCATGGATGGGAGCCACTGGTTCACCATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCATACACTCTGGAGGATCAGGACCGGGAGTTC
ATGGTTTTTGCCGATGCTCGCTGGACGGCACCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGTTGTTTTGATGCAGTGTTTCTCGATCCTTTT
GATGCCTGTGGCTTAATTGTTGCCAAATATTTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCCATGACTTTCAAGGAGAGAGTATGGAACCAC
ATCATGCACTTGGAGGAACATTTATTTTGCCCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAGTATCCCAAACCCGTGATGCCCAATATGATC
TTCATTGGTGGTATCAACTGTCATCAGGGAAAGCCAGTGCCTATGGGCATGCTGTTGAAGCGAAGTGGCAAATCGTTGAATAAAGAGTGG
AAAAAGAAATATGTCACCCTGTGTGACAATGGCGTGCTGACCTATCATCCCAGTTTACATGATTACATGCAGAATGTTCATGGTAAGGAG
ATTGACCTTCTGAGAACCACTGTGAAAGTCCCAGGGAAGAGGCCACCCCGAGCCACGTCAGCCTGCGCACCCATCTCCAGCCCTAAAACC
AATGGCCTATCCAAGGACATGAGCAGTTTACACATCTCACCCAATTCAGACACAGGGCTGGGTGACTCCGTATGCTCCAGCCCCAGTATC
TCCAGCACCACCAGCCCCAAGCTCGACCCGCCCCCCTCCCCTCACGCCAACAGAAAGAAGCACCGAAGGAAGAAAAGCACTAGCAACTTC
AAAGCCGACGGCCTGTCCGGCACTGCTGAAGAACAAGAAGAAAATTTTGAGTTTATCATTGTGTCCCTCACTGGCCAAACATGGCACTTT
GAAGCCACGACGTATGAGGAGCGGGACGCCTGGGTCCAAGCCATCGAGAGCCAGATCCTGGCCAGCCTGCAGTCGTGCGAGAGCAGCAAG
AACAAGTCCCGGCTGACGAGCCAGAGCGAGGCCATGGCCCTGCAGTCGATCCGGAACATGCGCGGGAACTCCCACTGTGTGGACTGCGAG
ACCCAGAATCCCAACTGGGCCAGTTTGAACTTGGGAGCCCTCATGTGCATCGAATGCTCAGGGATCCACCGGAATCTTGGCACCCACCTT
TCCCGAGTCCGATCTCTGGACCTGGATGACTGGCCAGTCGAGCTCATCAAGGTGATGTCATCCATCGGGAACGAGCTAGCCAACAGCGTC
TGGGAAGAGAGCAGCCAGGGGCGGACGAAACCATCGGTAGACTCCACAAGGGAAGAGAAGGAACGGTGGATCCGTGCCAAGTACGAGCAG
AAGCTCTTCCTGGCCCCGCTGCCCTGCACGGAGCTGTCCCTGGGCCAGCACCTGCTGCGGGCCACCGCCGACGAGGACCTGCGGACGGCC
ATCCTGCTGCTGGCACACGGCTCCCGGGACGAGGTGAACGAGACCTGCGGGGAGGGAGACGGCCGCACGGCGCTGCATCTGGCCTGCCGC
AAGGGGAATGTGGTCCTGGCGCAGCTCCTGATCTGGTACGGAGTGGACGTCACGGCCCGAGATGCCCACGGGAACACAGCTCTGGCCTAC
GCCCGGCAGGCCTCCAGCCAGGAGTGCATCGACGTGCTGCTGCAGTACGGCTGCCCCGACGAGCGCTTCGTGCTCATGGCCACCCCTAAC
CTGTCCAGGAGAAACAATAACCGGAACAACAGCAGTGGGAGGGTGCCCACCATCATCTGAGGAACAGCCGTGCCCGCCTGCTCGCCGCAC
CTGGGACGCGGCAGCCTCGCCGCATTCTCGCTCAGAAGTCGCAGCACGTGAGTCCCGTCGCATCCCCTCCCTCTTCCTGGTGGCCACCTC
CCTCCCGCCCACCCACTCTCACCCCAAACAAAATCACAAAACCTGGACATCCCTCAAGGGGCGAAGAGGCGGCCGGGAGACTGCAGAAGT
GGCTCCTTTTCATAAACTCCCCTAAACCACACACAGGAGAGAGCGACGGGCCTCGGCCCTTTGATGATAGCACATGGCGCAGGACCCTTG
TCCTGGTGGCACAAGGGATGGGGACGCGAGGGGGAGGGGAGGCGAGGAACAAGGAGAAGGGGCAACTTTCCTTAACTGGCAGTTGAGCAC
ATAGTACATTTCCCCTCTACCAAACGGAACACTTGGATTCCATCTCTTCTCTGAGGAGCTCGACGGCATAAATCAGAAGCAAGCACAGAG
TTTGTCAGGTTTGAAGCCCCTATGATGGTGTGTGTCAAATCAGTTGTAGCTAATCTGTCCAGGGAGAATACTGGCTTCATTACACTTGTA
CAGCCGAGTTCTTCCCGCATTACTGCTGTTTAATAGAACGTGATTAGTCATCGCCGAGAAGAAAGCATATTAGCCGAGGAGGTAGTCACG
CGGCACGCGCCGGTGATTGCCACGATGTGATTGCAATACTCTTAGAAGCACCATATTATCCCAGACATGTTCTTTCAAGCCCTTGGAGCC
CTCTCTAAATTCACTGTCATCATTTAGTATCTGTTTAATTTTTCAGTCCAAAGAGAGGAAATCAGTCGCTGAGTATTATTTGACTCCGGT
CTCCTTGGTGCAAAAACAAAATGGGAAAAATAAATAAGAATAACTCAGAAACTCAAAAGGAAACCACAAATTCAGCTAATAATAGCATTT
CGAGTATATTTCGTAAACTAAGGAAATACACAAAAGGCTGTTTTTTCCGACTGTAAGAGATATTTGATGTCCTTTTGCCGAGGTGGATGT
GTTAGTCTCAGGCCCTCCTGGACCACGTTGCCCAAGTCACACAGGCTTCTGTGTTATGTATTTAGATAAGATGTGTGAAAATATATTTGA
ATAAAAGAAGTTCATAAATATGCATTGATTTTTGTACAGACAAATGGCACCTCTCTTAATTTATAAATTGAACTGGATGTGAACTAATAA
TGTGCAACTAGTTGAGATAAGAGGGTTACAGATCATTGTACATGGAAAATATTCCCAGCAGTAAACACTTCCATTAATGTGATCTACGGC
TTTTGAAAAGGAGCATCTCAGAATAAGATGGTGGTACAATTTGCTTATTAAAATTGAGAAAGAAAAAAAAAGACACACTGGAGTATATTA
GAAAGGAAAAAGAAGGAATGTGGTCTCTCATGATTGAAAGCATGATTTAGATCGGATACGGCTTTTGCTAACCAAGGACCAAGGGACTCT
GGCAAGATGGGGTGGTTTTCCGAATGCCAGACCGAGGTGCCTTACGAAGGCAGCTGCCAATGGTTCTGTGGCACAGACTGGCTCCTGAGA
ACCCAGACGACCTTGACCTGGCAGCCCGGCCCTCCACGCTAGTACCTCGCCTGATTTTCCATCGTTGCGGTATCCAGCCGCTTCAGACGT
CCGCCGCCTTCAGTGGTGGTAGTCAAATGTAGTCAACCAAACCACAGCATCCCTTAGGTTAAAAGCAAACGGGGCAGCTTTGCCTAGAGC
TCATTGACAGTGTGATGGGGGGAGAAGGGTTGTCACAATGGAAGATGAGGACACTAGACTCATGTAGCACAGAAACATGAAGCCACACGC
ACCGGCAGCCTCCGGGGTGTTCCTCGCTCTCTCGTATGTTAAACCTTATATTTTATAAGAGTTTTTCCTCTTATTTCACTTTTTAAAAAA
AATTAAAGTAGGTGGGGAAAAAAATAAAGCTTTACACAGAATTTATATGTGGGTAAGTGTTTCATGGAAATTTCTAATCTTAACGAAGCT
AAGTGGAGCTCACTCGTATCCAAAAGTATAACAGGTGCAGAAGCCACAAGTCTGAGAACCTTGACGACAGTTCCATCGTCCTGCCATTTG
ATTTTTCAGTCTGCGTTTCATCACTGTGTAGCTATTGTAAATGTGAATAGAAAAAAACAGGTCATTGCCTATTTTTGAAGAACGCGTTGG
TGTTCGAGTCCACTAGACACACTCGCTCCACACAGCCTTCACCGTAGACTCTGTAGTGGACACAGATATAGCATAAATGAAATTGTTAAA
TTATTTCATTGTAGTTAATTCCCACTATAGGAATGCTTTATCATAGTGAAGTTTCTTTTGAGAAGAAACGGAACTCCTTGAGGCTTCTCT

>96666_96666_3_UGT1A7-AGAP1_UGT1A7_chr2_234591438_ENST00000373426_AGAP1_chr2_236791989_ENST00000409538_length(amino acids)=739AA_BP=285
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREF
MVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMI
FIGGINCHQGKPVPMGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKT
NGLSKDMSSLHISPNSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTWHF
EATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHL
SRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTA
ILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPN

--------------------------------------------------------------
>96666_96666_4_UGT1A7-AGAP1_UGT1A7_chr2_234591438_ENST00000373426_AGAP1_chr2_236791989_ENST00000428334_length(transcript)=2932nt_BP=855nt
ATGGCTCGTGCAGGGTGGACTGGCCTCCTTCCCCTATATGTGTGTCTACTGCTGACCTGTGGCTTTGCCAAGGCAGGGAAGCTGCTGGTA
GTGCCCATGGATGGGAGCCACTGGTTCACCATGCAGTCGGTGGTGGAGAAACTCATCCTCAGGGGGCATGAGGTGGTCGTAGTCATGCCA
GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTACTCAACCTCATACACTCTGGAGGATCAGGACCGGGAGTTC
ATGGTTTTTGCCGATGCTCGCTGGACGGCACCATTGCGAAGTGCATTTTCTCTATTAACAAGTTCATCCAATGGTATTTTTGACTTATTT
TTTTCAAATTGCAGGAGTTTGTTTAATGACCGAAAATTAGTAGAATACTTAAAGGAGAGTTGTTTTGATGCAGTGTTTCTCGATCCTTTT
GATGCCTGTGGCTTAATTGTTGCCAAATATTTCTCCCTCCCCTCTGTGGTCTTCGCCAGGGGAATATTTTGCCACTATCTTGAAGAAGGT
GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGACTTCTCTTAGGGTTCTCAGACGCCATGACTTTCAAGGAGAGAGTATGGAACCAC
ATCATGCACTTGGAGGAACATTTATTTTGCCCCTATTTTTTCAAAAATGTCTTAGAAATAGCCTCTGAAATTCTCCAAACCCCTGTCACG
GCATATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACTGACTTTGTTTTGGAGTATCCCAAACCCGTGATGCCCAATATGATC
TTCATTGGTGGTATCAACTGTCATCAGGGAAAGCCAGTGCCTATGGGCATGCTGTTGAAGCGAAGTGGCAAATCGTTGAATAAAGAGTGG
AAAAAGAAATATGTCACCCTGTGTGACAATGGCGTGCTGACCTATCATCCCAGTTTACATGATTACATGCAGAATGTTCATGGTAAGGAG
ATTGACCTTCTGAGAACCACTGTGAAAGTCCCAGGGAAGAGGCCACCCCGAGCCACGTCAGCCTGCGCACCCATCTCCAGCCCTAAAACC
AATGGCCTATCCAAGGACATGAGCAGTTTACACATCTCACCCAATTCAGGGAATGTCACTAGTGCATCTGGGTCTCAGATGGCAAGCGGC
ATCAGCCTGGTCTCCTTCAACAGCCGACCCGACGGCATGCACCAGCGCTCCTACTCAGTCTCCAGTGCCGACCAGTGGAGTGAGGCTACG
GTCATTGCAAACTCGGCCATCAGCAGTGACACAGGGCTGGGTGACTCCGTATGCTCCAGCCCCAGTATCTCCAGCACCACCAGCCCCAAG
CTCGACCCGCCCCCCTCCCCTCACGCCAACAGAAAGAAGCACCGAAGGAAGAAAAGCACTAGCAACTTCAAAGCCGACGGCCTGTCCGGC
ACTGCTGAAGAACAAGAAGAAAATTTTGAGTTTATCATTGTGTCCCTCACTGGCCAAACATGGCACTTTGAAGCCACGACGTATGAGGAG
CGGGACGCCTGGGTCCAAGCCATCGAGAGCCAGATCCTGGCCAGCCTGCAGTCGTGCGAGAGCAGCAAGAACAAGTCCCGGCTGACGAGC
CAGAGCGAGGCCATGGCCCTGCAGTCGATCCGGAACATGCGCGGGAACTCCCACTGTGTGGACTGCGAGACCCAGAATCCCAACTGGGCC
AGTTTGAACTTGGGAGCCCTCATGTGCATCGAATGCTCAGGGATCCACCGGAATCTTGGCACCCACCTTTCCCGAGTCCGATCTCTGGAC
CTGGATGACTGGCCAGTCGAGCTCATCAAGGTGATGTCATCCATCGGGAACGAGCTAGCCAACAGCGTCTGGGAAGAGAGCAGCCAGGGG
CGGACGAAACCATCGGTAGACTCCACAAGGGAAGAGAAGGAACGGTGGATCCGTGCCAAGTACGAGCAGAAGCTCTTCCTGGCCCCGCTG
CCCTGCACGGAGCTGTCCCTGGGCCAGCACCTGCTGCGGGCCACCGCCGACGAGGACCTGCGGACGGCCATCCTGCTGCTGGCACACGGC
TCCCGGGACGAGGTGAACGAGACCTGCGGGGAGGGAGACGGCCGCACGGCGCTGCATCTGGCCTGCCGCAAGGGGAATGTGGTCCTGGCG
CAGCTCCTGATCTGGTACGGAGTGGACGTCACGGCCCGAGATGCCCACGGGAACACAGCTCTGGCCTACGCCCGGCAGGCCTCCAGCCAG
GAGTGCATCGACGTGCTGCTGCAGTACGGCTGCCCCGACGAGCGCTTCGTGCTCATGGCCACCCCTAACCTGTCCAGGAGAAACAATAAC
CGGAACAACAGCAGTGGGAGGGTGCCCACCATCATCTGAGGAACAGCCGTGCCCGCCTGCTCGCCGCACCTGGGACGCGGCAGCCTCGCC
GCATTCTCGCTCAGAAGTCGCAGCACGTGAGTCCCGTCGCATCCCCTCCCTCTTCCTGGTGGCCACCTCCCTCCCGCCCACCCACTCTCA
CCCCAAACAAAATCACAAAACCTGGACATCCCTCAAGGGGCGAAGAGGCGGCCGGGAGACTGCAGAAGTGGCTCCTTTTCATAAACTCCC
CTAAACCACACACAGGAGAGAGCGACGGGCCTCGGCCCTTTGATGATAGCACATGGCGCAGGACCCTTGTCCTGGTGGCACAAGGGATGG
GGACGCGAGGGGGAGGGGAGGCGAGGAACAAGGAGAAGGGGCAACTTTCCTTAACTGGCAGTTGAGCACATAGTACATTTCCCCTCTACC
AAACGGAACACTTGGATTCCATCTCTTCTCTGAGGAGCTCGACGGCATAAATCAGAAGCAAGCACAGAGTTTGTCAGGTTTGAAGCCCCT

>96666_96666_4_UGT1A7-AGAP1_UGT1A7_chr2_234591438_ENST00000373426_AGAP1_chr2_236791989_ENST00000428334_length(amino acids)=792AA_BP=285
MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREF
MVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEG
AQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMI
FIGGINCHQGKPVPMGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPKT
NGLSKDMSSLHISPNSGNVTSASGSQMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSAISSDTGLGDSVCSSPSISSTTSPK
LDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTS
QSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQG
RTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLA

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Fusion Gene PPI Analysis for UGT1A7-AGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UGT1A7-AGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UGT1A7-AGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource