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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UHRF2-CBWD1 (FusionGDB2 ID:96730)

Fusion Gene Summary for UHRF2-CBWD1

check button Fusion gene summary
Fusion gene informationFusion gene name: UHRF2-CBWD1
Fusion gene ID: 96730
HgeneTgene
Gene symbol

UHRF2

CBWD1

Gene ID

115426

55871

Gene nameubiquitin like with PHD and ring finger domains 2COBW domain containing 1
SynonymsNIRF|RNF107|TDRD23|URF2COBP
Cytomap

9p24.1

9p24.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase UHRF2Np95-like ring finger proteinRING finger protein 107RING-type E3 ubiquitin transferase UHRF2np95/ICBP90-like RING finger proteinnuclear protein 97nuclear zinc finger protein NP97ubiquitin-like PHD and RING finger doCOBW domain-containing protein 1COBW-like proteinNPC-A-6 COBW domain-containing protein 1cobalamin synthase W domain-containing protein 1cobalamin synthetase W domain-containing protein 1
Modification date2020031320200313
UniProtAcc.

Q9BRT8

Ensembl transtripts involved in fusion geneENST00000276893, ENST00000381373, 
ENST00000485617, 		ENST00000377447, 
ENST00000382389, ENST00000382393, 
ENST00000431099, ENST00000475411, 
ENST00000314367, ENST00000356521, 
ENST00000377400, ENST00000382447, 
Fusion gene scores* DoF score7 X 5 X 5=1754 X 4 X 2=32
# samples 63
** MAII scorelog2(6/175*10)=-1.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/32*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UHRF2 [Title/Abstract] AND CBWD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUHRF2(6421142)-CBWD1(121573), # samples:1
Anticipated loss of major functional domain due to fusion event.UHRF2-CBWD1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
UHRF2-CBWD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
UHRF2-CBWD1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
UHRF2-CBWD1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUHRF2

GO:0016567

protein ubiquitination

14741369

HgeneUHRF2

GO:0051865

protein autoubiquitination

14741369

HgeneUHRF2

GO:0071158

positive regulation of cell cycle arrest

15178429


check buttonFusion gene breakpoints across UHRF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CBWD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4983-01AUHRF2chr9

6421142

+CBWD1chr9

121573

-


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Fusion Gene ORF analysis for UHRF2-CBWD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000276893ENST00000377447UHRF2chr9

6421142

+CBWD1chr9

121573

-
5CDS-intronENST00000276893ENST00000382389UHRF2chr9

6421142

+CBWD1chr9

121573

-
5CDS-intronENST00000276893ENST00000382393UHRF2chr9

6421142

+CBWD1chr9

121573

-
5CDS-intronENST00000276893ENST00000431099UHRF2chr9

6421142

+CBWD1chr9

121573

-
5CDS-intronENST00000276893ENST00000475411UHRF2chr9

6421142

+CBWD1chr9

121573

-
5CDS-intronENST00000381373ENST00000377447UHRF2chr9

6421142

+CBWD1chr9

121573

-
5CDS-intronENST00000381373ENST00000382389UHRF2chr9

6421142

+CBWD1chr9

121573

-
5CDS-intronENST00000381373ENST00000382393UHRF2chr9

6421142

+CBWD1chr9

121573

-
5CDS-intronENST00000381373ENST00000431099UHRF2chr9

6421142

+CBWD1chr9

121573

-
5CDS-intronENST00000381373ENST00000475411UHRF2chr9

6421142

+CBWD1chr9

121573

-
Frame-shiftENST00000276893ENST00000314367UHRF2chr9

6421142

+CBWD1chr9

121573

-
Frame-shiftENST00000276893ENST00000356521UHRF2chr9

6421142

+CBWD1chr9

121573

-
Frame-shiftENST00000381373ENST00000314367UHRF2chr9

6421142

+CBWD1chr9

121573

-
Frame-shiftENST00000381373ENST00000356521UHRF2chr9

6421142

+CBWD1chr9

121573

-
In-frameENST00000276893ENST00000377400UHRF2chr9

6421142

+CBWD1chr9

121573

-
In-frameENST00000276893ENST00000382447UHRF2chr9

6421142

+CBWD1chr9

121573

-
In-frameENST00000381373ENST00000377400UHRF2chr9

6421142

+CBWD1chr9

121573

-
In-frameENST00000381373ENST00000382447UHRF2chr9

6421142

+CBWD1chr9

121573

-
intron-3CDSENST00000485617ENST00000314367UHRF2chr9

6421142

+CBWD1chr9

121573

-
intron-3CDSENST00000485617ENST00000356521UHRF2chr9

6421142

+CBWD1chr9

121573

-
intron-3CDSENST00000485617ENST00000377400UHRF2chr9

6421142

+CBWD1chr9

121573

-
intron-3CDSENST00000485617ENST00000382447UHRF2chr9

6421142

+CBWD1chr9

121573

-
intron-intronENST00000485617ENST00000377447UHRF2chr9

6421142

+CBWD1chr9

121573

-
intron-intronENST00000485617ENST00000382389UHRF2chr9

6421142

+CBWD1chr9

121573

-
intron-intronENST00000485617ENST00000382393UHRF2chr9

6421142

+CBWD1chr9

121573

-
intron-intronENST00000485617ENST00000431099UHRF2chr9

6421142

+CBWD1chr9

121573

-
intron-intronENST00000485617ENST00000475411UHRF2chr9

6421142

+CBWD1chr9

121573

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000276893UHRF2chr96421142+ENST00000377400CBWD1chr9121573-108455260563167
ENST00000276893UHRF2chr96421142+ENST00000382447CBWD1chr9121573-71755260563167
ENST00000381373UHRF2chr96421142+ENST00000377400CBWD1chr9121573-98945773468131
ENST00000381373UHRF2chr96421142+ENST00000382447CBWD1chr9121573-62245773468131

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000276893ENST00000377400UHRF2chr96421142+CBWD1chr9121573-0.0271043130.9728957
ENST00000276893ENST00000382447UHRF2chr96421142+CBWD1chr9121573-0.094244730.9057553
ENST00000381373ENST00000377400UHRF2chr96421142+CBWD1chr9121573-0.0307487210.9692513
ENST00000381373ENST00000382447UHRF2chr96421142+CBWD1chr9121573-0.095756590.9042434

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Fusion Genomic Features for UHRF2-CBWD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UHRF2-CBWD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:6421142/chr9:121573)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CBWD1

Q9BRT8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUHRF2chr9:6421142chr9:121573ENST00000276893+2161_78128803.0DomainUbiquitin-like
TgeneCBWD1chr9:6421142chr9:121573ENST0000038239303274_3770114.0DomainNote=CobW C-terminal
TgeneCBWD1chr9:6421142chr9:121573ENST0000038239303110_1140114.0Nucleotide bindingATP
TgeneCBWD1chr9:6421142chr9:121573ENST0000038239303203_2060114.0Nucleotide bindingATP
TgeneCBWD1chr9:6421142chr9:121573ENST000003823930349_560114.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUHRF2chr9:6421142chr9:121573ENST00000276893+216448_612128803.0DomainYDG
HgeneUHRF2chr9:6421142chr9:121573ENST00000276893+216344_395128803.0Zinc fingerPHD-type
HgeneUHRF2chr9:6421142chr9:121573ENST00000276893+216733_772128803.0Zinc fingerRING-type
TgeneCBWD1chr9:6421142chr9:121573ENST000003143671416274_377324360.0DomainNote=CobW C-terminal
TgeneCBWD1chr9:6421142chr9:121573ENST000003565211315274_377360396.0DomainNote=CobW C-terminal
TgeneCBWD1chr9:6421142chr9:121573ENST000003824471214274_377341377.0DomainNote=CobW C-terminal
TgeneCBWD1chr9:6421142chr9:121573ENST000003143671416110_114324360.0Nucleotide bindingATP
TgeneCBWD1chr9:6421142chr9:121573ENST000003143671416203_206324360.0Nucleotide bindingATP
TgeneCBWD1chr9:6421142chr9:121573ENST00000314367141649_56324360.0Nucleotide bindingATP
TgeneCBWD1chr9:6421142chr9:121573ENST000003565211315110_114360396.0Nucleotide bindingATP
TgeneCBWD1chr9:6421142chr9:121573ENST000003565211315203_206360396.0Nucleotide bindingATP
TgeneCBWD1chr9:6421142chr9:121573ENST00000356521131549_56360396.0Nucleotide bindingATP
TgeneCBWD1chr9:6421142chr9:121573ENST000003824471214110_114341377.0Nucleotide bindingATP
TgeneCBWD1chr9:6421142chr9:121573ENST000003824471214203_206341377.0Nucleotide bindingATP
TgeneCBWD1chr9:6421142chr9:121573ENST00000382447121449_56341377.0Nucleotide bindingATP


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Fusion Gene Sequence for UHRF2-CBWD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96730_96730_1_UHRF2-CBWD1_UHRF2_chr9_6421142_ENST00000276893_CBWD1_chr9_121573_ENST00000377400_length(transcript)=1084nt_BP=552nt
AGAGTCGTCGCCGCCTGTCGGGCCCGGCGTCCGGTCGGTCCGGTGGGCGCGCTCGCCCGCCTGCCGCTGAGGGCCCGAGCCGCAGGGAAA
GCGGCGCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAG
GTTCGCACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCG
CTGTTCGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGA
CTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAAT
AGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTT
GGAATATATAAGGCAGAAATTTAGATAAGGATATCCTTAAACAGCTGTTTATAGCTACTGTGACAGAAACAGAAAAGCAGTGGACAACAC
GTTTCCAAGAAGATCAAGTTTGTACATAACACTAGAGGCATTTCTTATCAAAAGGATTGGATAATAAAAATAAGTTTCTACTGGGTATAT
TTCAAGCATTTATTTATTACTTTAGTTACGAATTCCAATATACTTTAAAATGGTATTTGTTTTACAGCATACATAAAATGTAGCAAATCA
GTACTGTAAAACATTTAACATTCATACAGTTATATATAATATCCTTTTTTTTAAAGAATGGTATTTCACAAAAATATCTTTTGAAATTGG
CTTTGGAGTTTACATATACTGAACATGAAAGTTTATAATAATGATGATACAACTTTCAACATTGTCATTTTTTCTTAGAACTTCAGCTGA
TTGCAGAGATATAATGATTACATTGTTATTAAATTTTTTTAACACAAGTAAGTGTCACCATTTTATGACATGAAATAAAAGGTTATGACT

>96730_96730_1_UHRF2-CBWD1_UHRF2_chr9_6421142_ENST00000276893_CBWD1_chr9_121573_ENST00000377400_length(amino acids)=167AA_BP=
MPLRARAAGKAARAGRGAAPRAQGETKGTGSSLGAKMWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLEN

--------------------------------------------------------------
>96730_96730_2_UHRF2-CBWD1_UHRF2_chr9_6421142_ENST00000276893_CBWD1_chr9_121573_ENST00000382447_length(transcript)=717nt_BP=552nt
AGAGTCGTCGCCGCCTGTCGGGCCCGGCGTCCGGTCGGTCCGGTGGGCGCGCTCGCCCGCCTGCCGCTGAGGGCCCGAGCCGCAGGGAAA
GCGGCGCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAG
GTTCGCACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCG
CTGTTCGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGA
CTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAAT
AGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTT
GGAATATATAAGGCAGAAATTTAGATAAGGATATCCTTAAACAGCTGTTTATAGCTACTGTGACAGAAACAGAAAAGCAGTGGACAACAC

>96730_96730_2_UHRF2-CBWD1_UHRF2_chr9_6421142_ENST00000276893_CBWD1_chr9_121573_ENST00000382447_length(amino acids)=167AA_BP=
MPLRARAAGKAARAGRGAAPRAQGETKGTGSSLGAKMWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLEN

--------------------------------------------------------------
>96730_96730_3_UHRF2-CBWD1_UHRF2_chr9_6421142_ENST00000381373_CBWD1_chr9_121573_ENST00000377400_length(transcript)=989nt_BP=457nt
GCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAGGTTCG
CACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCGCTGTT
CGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGACTGAA
TGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAATAGTCC
ACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTTGGAAT
ATATAAGGCAGAAATTTAGATAAGGATATCCTTAAACAGCTGTTTATAGCTACTGTGACAGAAACAGAAAAGCAGTGGACAACACGTTTC
CAAGAAGATCAAGTTTGTACATAACACTAGAGGCATTTCTTATCAAAAGGATTGGATAATAAAAATAAGTTTCTACTGGGTATATTTCAA
GCATTTATTTATTACTTTAGTTACGAATTCCAATATACTTTAAAATGGTATTTGTTTTACAGCATACATAAAATGTAGCAAATCAGTACT
GTAAAACATTTAACATTCATACAGTTATATATAATATCCTTTTTTTTAAAGAATGGTATTTCACAAAAATATCTTTTGAAATTGGCTTTG
GAGTTTACATATACTGAACATGAAAGTTTATAATAATGATGATACAACTTTCAACATTGTCATTTTTTCTTAGAACTTCAGCTGATTGCA

>96730_96730_3_UHRF2-CBWD1_UHRF2_chr9_6421142_ENST00000381373_CBWD1_chr9_121573_ENST00000377400_length(amino acids)=131AA_BP=
MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAK

--------------------------------------------------------------
>96730_96730_4_UHRF2-CBWD1_UHRF2_chr9_6421142_ENST00000381373_CBWD1_chr9_121573_ENST00000382447_length(transcript)=622nt_BP=457nt
GCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAGGTTCG
CACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCGCTGTT
CGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGACTGAA
TGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAATAGTCC
ACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTTGGAAT
ATATAAGGCAGAAATTTAGATAAGGATATCCTTAAACAGCTGTTTATAGCTACTGTGACAGAAACAGAAAAGCAGTGGACAACACGTTTC

>96730_96730_4_UHRF2-CBWD1_UHRF2_chr9_6421142_ENST00000381373_CBWD1_chr9_121573_ENST00000382447_length(amino acids)=131AA_BP=
MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for UHRF2-CBWD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneUHRF2chr9:6421142chr9:121573ENST00000276893+216194_288128.0803.0PCNP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UHRF2-CBWD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UHRF2-CBWD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource