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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:UHRF2-LSM3 (FusionGDB2 ID:96732)

Fusion Gene Summary for UHRF2-LSM3

Fusion gene summary

Fusion gene information	Fusion gene name: UHRF2-LSM3
	Fusion gene ID: 96732
		Hgene	Tgene
	Gene symbol	UHRF2	LSM3
	Gene ID	115426	27258
	Gene name	ubiquitin like with PHD and ring finger domains 2	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
	Synonyms	NIRF\|RNF107\|TDRD23\|URF2	SMX4\|USS2\|YLR438C
	Cytomap	9p24.1	3p25.1
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase UHRF2Np95-like ring finger proteinRING finger protein 107RING-type E3 ubiquitin transferase UHRF2np95/ICBP90-like RING finger proteinnuclear protein 97nuclear zinc finger protein NP97ubiquitin-like PHD and RING finger do	U6 snRNA-associated Sm-like protein LSm3LSM3 U6 small nuclear RNA and mRNA degradation associatedLSM3 homolog, U6 small nuclear RNA associated
	Modification date	20200313	20200313
	UniProtAcc	.	P62310
	Ensembl transtripts involved in fusion gene	ENST00000276893, ENST00000381373, ENST00000485617,	ENST00000306024,
Fusion gene scores	* DoF score	7 X 5 X 5=175	8 X 7 X 4=224
	# samples	6	8
	** MAII score	log2(6/175*10)=-1.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: UHRF2 [Title/Abstract] AND LSM3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	UHRF2(6421142)-LSM3(14239535), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	UHRF2	GO:0016567	protein ubiquitination	14741369
Hgene	UHRF2	GO:0051865	protein autoubiquitination	14741369
Hgene	UHRF2	GO:0071158	positive regulation of cell cycle arrest	15178429
Tgene	LSM3	GO:0000398	mRNA splicing, via spliceosome	10369684\|10523320\|28781166

Fusion gene breakpoints across UHRF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LSM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-10-0931	UHRF2	chr9	6421142	+	LSM3	chr3	14239535	+

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Fusion Gene ORF analysis for UHRF2-LSM3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000276893	ENST00000306024	UHRF2	chr9	6421142	+	LSM3	chr3	14239535	+
In-frame	ENST00000381373	ENST00000306024	UHRF2	chr9	6421142	+	LSM3	chr3	14239535	+
intron-3CDS	ENST00000485617	ENST00000306024	UHRF2	chr9	6421142	+	LSM3	chr3	14239535	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000276893

UHRF2

chr9

6421142

ENST00000306024

LSM3

chr3

14239535

3636

552

632

190

ENST00000381373

UHRF2

chr9

6421142

ENST00000306024

LSM3

chr3

14239535

3541

457

537

154

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000276893	ENST00000306024	UHRF2	chr9	6421142	+	LSM3	chr3	14239535	+	0.012390891	0.98760915
ENST00000381373	ENST00000306024	UHRF2	chr9	6421142	+	LSM3	chr3	14239535	+	0.011849603	0.98815036

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Fusion Genomic Features for UHRF2-LSM3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
UHRF2	chr9	6421142	+	LSM3	chr3	14239535	+	1.43E-05	0.9999857
UHRF2	chr9	6421142	+	LSM3	chr3	14239535	+	1.43E-05	0.9999857

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UHRF2-LSM3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:6421142/chr3:14239535)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LSM3 P62310
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269\|PubMed:10523320, ECO:0000269\|PubMed:28781166}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UHRF2

chr9:6421142

chr3:14239535

ENST00000276893

1_78

128

803.0

Domain

Ubiquitin-like

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UHRF2

chr9:6421142

chr3:14239535

ENST00000276893

448_612

128

803.0

Domain

YDG

Hgene

UHRF2

chr9:6421142

chr3:14239535

ENST00000276893

344_395

128

803.0

Zinc finger

PHD-type

Hgene

UHRF2

chr9:6421142

chr3:14239535

ENST00000276893

733_772

128

803.0

Zinc finger

RING-type

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Fusion Gene Sequence for UHRF2-LSM3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>96732_96732_1_UHRF2-LSM3_UHRF2_chr9_6421142_ENST00000276893_LSM3_chr3_14239535_ENST00000306024_length(transcript)=3636nt_BP=552nt
AGAGTCGTCGCCGCCTGTCGGGCCCGGCGTCCGGTCGGTCCGGTGGGCGCGCTCGCCCGCCTGCCGCTGAGGGCCCGAGCCGCAGGGAAA
GCGGCGCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAG
GTTCGCACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCG
CTGTTCGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGA
CTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAAT
AGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTT
GGAATATATAAGTCAACGAAACGGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTGCCCCTCCACTGAGAGTTGGC
TGAAACAAAGAATTTGTCCTGTATGGAAAACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAACCTGCA
TACATTTTGATATTAAGAAATAATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAGCTAAAT
GGTATTTTCATTTTTCTCAAGCTCTCCAATAAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCTTTTGCTCCATTATTCTCACA
GATACTTACTGATTTTTCTTTTCTTTAAATTGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGTCTTGTGAATTATTTAAAGTA
AGCATGTCTTACCTTCACTTAGCACACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGTTTTATC
AAAATGCTTTCTGGGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGCG
TTTGAGACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGTAATCCC
AGCTACTCAGGAGGCTGAGGCAGTAGACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTTCAACCTGG
TCAACAGAGCGAGACTCCGTGTCAAAAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGGCAGATGTTTAAACCAACAAT
TGCAGGCAGTAAGATTAGTGCTGATAGAATCATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCACCCAAATATGGGAGAAAGGG
GCAGAGGGACATTGTAAACATCAACCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCTAAGGTC
AGACGTTCAGCTTGATCATAACCTGTTTATAATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGGCCATTAATGATGAGGGGTCT
CAAACAACATGTCTCAGTGACACAGTAAAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCTTCAGTCAGCACATAATGCTT
AAAACCTAAAGAGGAAAGTAAAAGCGTGTTACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTGACATCCTCCGCTATGGTCAT
TCCATTTTGAAATGTAGAAAATCCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAAGCACGATAT
GCTCACAAATGCACAGTACTTTAAGCCTTGTGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTTTATTTTCCTTACTAATGGTA
CATGCCCCTGCAAGTTCATGGAGAAGAGAAAAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGTGAGGAGGCAGGAGAGACACC
CTCCCTTCACTTGTGCCATCCCCACGCTTTGTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAGTATTGA
AAAATGAACTCCCTCCTGCAGAATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTGGCAGCAAGATTGA
ACCTGCCTGCCTCCTACCTGTGTGAGCCTGTGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGTGTTCAC
TAAGGCGTGGGGTGACAGGCCATCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGTGGTTTCTGATAGT
CACACTGAATTCCTGGACACTTTCTTCTCTTCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAAACTTTT
GGCTGTGAGGACTTGATTATACACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCACACACAACTAAAACA
TACCAACCTACTTCATTTCCTAGCTGCTAAGATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATAGCCACCTATGTGTCAGGAAA
TGGAGGGAGGGGAGGCAATGTGTGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCAGGGCCCTGCCATGGTCCA
CACTGAGGTTTCCTCTGCAGTGGTGCTGTCCACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAGTCTGCA
GAGCACTCGGCTCCAGCCAGCTGGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGGTGTCAGATTAGCCTAAGG
GAAGCCTCTTCAGCAAGTATCATGCCTGGATCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCACAAAGAA
AAATGGACAAAATATGGGACCACATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCCCAAGTTAAACTTAATCATTA
GCTGCAAATGGACGATTTTCAAATTTCAAATAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAGAGGCAG
AAAGTGGTTTCACACACCCTTTTATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAACCACTAAGGAGACTGAGGCG
GGAGGATTACTTGAGCCCAGGAGTTCGAGATCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCCATATTG
CTTTTAGCCTGCTGCCAGGAGGGGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAGCTGTGTTCAATGTAGAAAAT

>96732_96732_1_UHRF2-LSM3_UHRF2_chr9_6421142_ENST00000276893_LSM3_chr3_14239535_ENST00000306024_length(amino acids)=190AA_BP=164
MPLRARAAGKAARAGRGAAPRAQGETKGTGSSLGAKMWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLEN
GYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKSTKRNIPMLFVRGDGV

--------------------------------------------------------------
>96732_96732_2_UHRF2-LSM3_UHRF2_chr9_6421142_ENST00000381373_LSM3_chr3_14239535_ENST00000306024_length(transcript)=3541nt_BP=457nt
GCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAGGTTCG
CACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCGCTGTT
CGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGACTGAA
TGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAATAGTCC
ACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTTGGAAT
ATATAAGTCAACGAAACGGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGTTGTCCTGGTTGCCCCTCCACTGAGAGTTGGCTGAAA
CAAAGAATTTGTCCTGTATGGAAAACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAACCTGCATACAT
TTTGATATTAAGAAATAATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAGCTAAATGGTAT
TTTCATTTTTCTCAAGCTCTCCAATAAATATGACCACCAAGATGCAGAACTCTTTCAGGACTTCTTTTGCTCCATTATTCTCACAGATAC
TTACTGATTTTTCTTTTCTTTAAATTGGTGTTTCCTTGTAGATTTTTTTAAGTGCGGTCTTCTGTCTTGTGAATTATTTAAAGTAAGCAT
GTCTTACCTTCACTTAGCACACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGTTTTATCAAAAT
GCTTTCTGGGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGCGTTTGA
GACCAGCCTGGCCAACATGGTGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGTAATCCCAGCTA
CTCAGGAGGCTGAGGCAGTAGACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCATTGCACTTCAACCTGGTCAAC
AGAGCGAGACTCCGTGTCAAAAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCTTCTGGGGAGGCAGATGTTTAAACCAACAATTGCAG
GCAGTAAGATTAGTGCTGATAGAATCATGCACATGCAGGATGCCATAGGAGCATGGGGAAGAGCACCCAAATATGGGAGAAAGGGGCAGA
GGGACATTGTAAACATCAACCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCTAAGGTCAGACG
TTCAGCTTGATCATAACCTGTTTATAATTATGACTCAGACCATTTTTCCACTCTTGGATCATTGGCCATTAATGATGAGGGGTCTCAAAC
AACATGTCTCAGTGACACAGTAAAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGCTTCAGTCAGCACATAATGCTTAAAAC
CTAAAGAGGAAAGTAAAAGCGTGTTACAATCTCTCAAACTTTATCAAGACAGGGCTTAGAACCTGACATCCTCCGCTATGGTCATTCCAT
TTTGAAATGTAGAAAATCCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAAGCACGATATGCTCA
CAAATGCACAGTACTTTAAGCCTTGTGCAAGAAAGATGCTTTCAGTAAACATATTTAAAAGGTTTTATTTTCCTTACTAATGGTACATGC
CCCTGCAAGTTCATGGAGAAGAGAAAAACAAGTGTGGGTGAGCTGATGGAGGCTTCATCTTAGGTGAGGAGGCAGGAGAGACACCCTCCC
TTCACTTGTGCCATCCCCACGCTTTGTCCTTAAGCTGTAGTGGTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAGTATTGAAAAAT
GAACTCCCTCCTGCAGAATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTGGCAGCAAGATTGAACCTG
CCTGCCTCCTACCTGTGTGAGCCTGTGGTGTGGGTGTGGTACCAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGTGTTCACTAAGG
CGTGGGGTGACAGGCCATCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGTGGTTTCTGATAGTCACAC
TGAATTCCTGGACACTTTCTTCTCTTCATTCTTAGTTATCTTTCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAAACTTTTGGCTG
TGAGGACTTGATTATACACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCACACACAACTAAAACATACCA
ACCTACTTCATTTCCTAGCTGCTAAGATACAAGGGGAGGGACAATAAAAGGTTAACTGCAGAATAGCCACCTATGTGTCAGGAAATGGAG
GGAGGGGAGGCAATGTGTGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCAGGGCCCTGCCATGGTCCACACTG
AGGTTTCCTCTGCAGTGGTGCTGTCCACTGAGGGGTTATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAGTCTGCAGAGCA
CTCGGCTCCAGCCAGCTGGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGGTGTCAGATTAGCCTAAGGGAAGC
CTCTTCAGCAAGTATCATGCCTGGATCCCGGTCTTGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCACAAAGAAAAATG
GACAAAATATGGGACCACATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATCCCAAGTTAAACTTAATCATTAGCTGC
AAATGGACGATTTTCAAATTTCAAATAGTGATTTTTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAGAGGCAGAAAGT
GGTTTCACACACCCTTTTATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCAACCACTAAGGAGACTGAGGCGGGAGG
ATTACTTGAGCCCAGGAGTTCGAGATCAGCCTGAGCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCCATATTGCTTTT
AGCCTGCTGCCAGGAGGGGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCAGCTGTGTTCAATGTAGAAAATTAATA

>96732_96732_2_UHRF2-LSM3_UHRF2_chr9_6421142_ENST00000381373_LSM3_chr3_14239535_ENST00000306024_length(amino acids)=154AA_BP=128
MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for UHRF2-LSM3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	UHRF2	chr9:6421142	chr3:14239535	ENST00000276893	+	2	16	194_288	128.0	803.0	PCNP

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for UHRF2-LSM3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for UHRF2-LSM3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source