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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UHRF2-PUM2 (FusionGDB2 ID:96735)

Fusion Gene Summary for UHRF2-PUM2

check button Fusion gene summary
Fusion gene informationFusion gene name: UHRF2-PUM2
Fusion gene ID: 96735
HgeneTgene
Gene symbol

UHRF2

PUM2

Gene ID

115426

23369

Gene nameubiquitin like with PHD and ring finger domains 2pumilio RNA binding family member 2
SynonymsNIRF|RNF107|TDRD23|URF2PUMH2|PUML2
Cytomap

9p24.1

2p24.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase UHRF2Np95-like ring finger proteinRING finger protein 107RING-type E3 ubiquitin transferase UHRF2np95/ICBP90-like RING finger proteinnuclear protein 97nuclear zinc finger protein NP97ubiquitin-like PHD and RING finger dopumilio homolog 2pumilio-2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000485617, ENST00000276893, 
ENST00000381373, 		ENST00000319801, 
ENST00000338086, ENST00000361078, 
ENST00000403432, ENST00000536417, 
ENST00000420234, 
Fusion gene scores* DoF score7 X 5 X 5=17511 X 9 X 5=495
# samples 613
** MAII scorelog2(6/175*10)=-1.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/495*10)=-1.92891690193852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UHRF2 [Title/Abstract] AND PUM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUHRF2(6506093)-PUM2(20451426), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUHRF2

GO:0016567

protein ubiquitination

14741369

HgeneUHRF2

GO:0051865

protein autoubiquitination

14741369

HgeneUHRF2

GO:0071158

positive regulation of cell cycle arrest

15178429

TgenePUM2

GO:0010608

posttranscriptional regulation of gene expression

25100735

TgenePUM2

GO:0043488

regulation of mRNA stability

26724866

TgenePUM2

GO:0051983

regulation of chromosome segregation

26724866

TgenePUM2

GO:1900246

positive regulation of RIG-I signaling pathway

25340845


check buttonFusion gene breakpoints across UHRF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PUM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE697670UHRF2chr9

6506093

-PUM2chr2

20451426

-
ChiTaRS5.0N/ABE697672UHRF2chr9

6506093

-PUM2chr2

20451426

-


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Fusion Gene ORF analysis for UHRF2-PUM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000485617ENST00000319801UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-3CDSENST00000485617ENST00000338086UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-3CDSENST00000485617ENST00000361078UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-3CDSENST00000485617ENST00000403432UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-3CDSENST00000485617ENST00000536417UHRF2chr9

6506093

-PUM2chr2

20451426

-
3UTR-intronENST00000485617ENST00000420234UHRF2chr9

6506093

-PUM2chr2

20451426

-
5CDS-intronENST00000276893ENST00000420234UHRF2chr9

6506093

-PUM2chr2

20451426

-
In-frameENST00000276893ENST00000319801UHRF2chr9

6506093

-PUM2chr2

20451426

-
In-frameENST00000276893ENST00000338086UHRF2chr9

6506093

-PUM2chr2

20451426

-
In-frameENST00000276893ENST00000361078UHRF2chr9

6506093

-PUM2chr2

20451426

-
In-frameENST00000276893ENST00000403432UHRF2chr9

6506093

-PUM2chr2

20451426

-
In-frameENST00000276893ENST00000536417UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-3CDSENST00000381373ENST00000319801UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-3CDSENST00000381373ENST00000338086UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-3CDSENST00000381373ENST00000361078UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-3CDSENST00000381373ENST00000403432UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-3CDSENST00000381373ENST00000536417UHRF2chr9

6506093

-PUM2chr2

20451426

-
intron-intronENST00000381373ENST00000420234UHRF2chr9

6506093

-PUM2chr2

20451426

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000276893UHRF2chr96506093-ENST00000338086PUM2chr220451426-63663391602450796
ENST00000276893UHRF2chr96506093-ENST00000319801PUM2chr220451426-63653391602450796
ENST00000276893UHRF2chr96506093-ENST00000361078PUM2chr220451426-63653391602450796
ENST00000276893UHRF2chr96506093-ENST00000536417PUM2chr220451426-37473391602450796
ENST00000276893UHRF2chr96506093-ENST00000403432PUM2chr220451426-37473391602450796

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000276893ENST00000338086UHRF2chr96506093-PUM2chr220451426-0.0003763330.99962366
ENST00000276893ENST00000319801UHRF2chr96506093-PUM2chr220451426-0.0003757160.99962425
ENST00000276893ENST00000361078UHRF2chr96506093-PUM2chr220451426-0.0003757160.99962425
ENST00000276893ENST00000536417UHRF2chr96506093-PUM2chr220451426-0.0004669010.9995332
ENST00000276893ENST00000403432UHRF2chr96506093-PUM2chr220451426-0.0004669010.9995332

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Fusion Genomic Features for UHRF2-PUM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UHRF2-PUM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:6506093/chr2:20451426)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019278_4880988.0Compositional biasNote=Ala-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019359_4050988.0Compositional biasNote=Gln-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019520_6870988.0Compositional biasNote=Ser-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020278_48801065.0Compositional biasNote=Ala-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020359_40501065.0Compositional biasNote=Gln-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020520_68701065.0Compositional biasNote=Ser-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020278_48801067.0Compositional biasNote=Ala-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020359_40501067.0Compositional biasNote=Gln-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020520_68701067.0Compositional biasNote=Ser-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021278_48801065.0Compositional biasNote=Ala-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021359_40501065.0Compositional biasNote=Gln-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021520_68701065.0Compositional biasNote=Ser-rich
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019706_10480988.0DomainPUM-HD
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020706_104801065.0DomainPUM-HD
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020706_104801067.0DomainPUM-HD
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021706_104801065.0DomainPUM-HD
TgenePUM2chr9:6506093chr2:20451426ENST000003198010191002_10060988.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019741_7450988.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019777_7810988.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019813_8170988.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019851_8550988.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019887_8910988.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019923_9270988.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019959_9630988.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST000003380860201002_100601065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020741_74501065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020777_78101065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020813_81701065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020851_85501065.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020887_89101065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020923_92701065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020959_96301065.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST000003610780201002_100601067.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020741_74501067.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020777_78101067.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020813_81701067.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020851_85501067.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020887_89101067.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020923_92701067.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020959_96301067.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST000004034320211002_100601065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021741_74501065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021777_78101065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021813_81701065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021851_85501065.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021887_89101065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021923_92701065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021959_96301065.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019726_7610988.0RepeatPumilio 1
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019762_7970988.0RepeatPumilio 2
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019798_8350988.0RepeatPumilio 3
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019836_8710988.0RepeatPumilio 4
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019872_9070988.0RepeatPumilio 5
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019908_9430988.0RepeatPumilio 6
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019944_9790988.0RepeatPumilio 7
TgenePUM2chr9:6506093chr2:20451426ENST00000319801019983_10220988.0RepeatPumilio 8
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020726_76101065.0RepeatPumilio 1
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020762_79701065.0RepeatPumilio 2
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020798_83501065.0RepeatPumilio 3
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020836_87101065.0RepeatPumilio 4
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020872_90701065.0RepeatPumilio 5
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020908_94301065.0RepeatPumilio 6
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020944_97901065.0RepeatPumilio 7
TgenePUM2chr9:6506093chr2:20451426ENST00000338086020983_102201065.0RepeatPumilio 8
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020726_76101067.0RepeatPumilio 1
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020762_79701067.0RepeatPumilio 2
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020798_83501067.0RepeatPumilio 3
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020836_87101067.0RepeatPumilio 4
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020872_90701067.0RepeatPumilio 5
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020908_94301067.0RepeatPumilio 6
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020944_97901067.0RepeatPumilio 7
TgenePUM2chr9:6506093chr2:20451426ENST00000361078020983_102201067.0RepeatPumilio 8
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021726_76101065.0RepeatPumilio 1
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021762_79701065.0RepeatPumilio 2
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021798_83501065.0RepeatPumilio 3
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021836_87101065.0RepeatPumilio 4
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021872_90701065.0RepeatPumilio 5
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021908_94301065.0RepeatPumilio 6
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021944_97901065.0RepeatPumilio 7
TgenePUM2chr9:6506093chr2:20451426ENST00000403432021983_102201065.0RepeatPumilio 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUHRF2chr9:6506093chr2:20451426ENST00000276893-1161_780803.0DomainUbiquitin-like
HgeneUHRF2chr9:6506093chr2:20451426ENST00000276893-116448_6120803.0DomainYDG
HgeneUHRF2chr9:6506093chr2:20451426ENST00000276893-116344_3950803.0Zinc fingerPHD-type
HgeneUHRF2chr9:6506093chr2:20451426ENST00000276893-116733_7720803.0Zinc fingerRING-type


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Fusion Gene Sequence for UHRF2-PUM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96735_96735_1_UHRF2-PUM2_UHRF2_chr9_6506093_ENST00000276893_PUM2_chr2_20451426_ENST00000319801_length(transcript)=6365nt_BP=3391nt
AGAGTCGTCGCCGCCTGTCGGGCCCGGCGTCCGGTCGGTCCGGTGGGCGCGCTCGCCCGCCTGCCGCTGAGGGCCCGAGCCGCAGGGAAA
GCGGCGCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAG
GTTCGCACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCG
CTGTTCGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGA
CTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAAT
AGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTT
GGAATATATAAGGTAAATGAATTGGTGGATGCCAGAGATGTCGGCCTTGGTGCTTGGTTTGAAGCACACATACATAGTGTTACTAGAGCT
TCTGATGGACAGTCACGTGGCAAAACTCCACTGAAGAATGGCAGTTCTTGTAAAAGGACTAATGGAAATATAAAGCATAAATCCAAAGAG
AACACAAATAAATTGGACAGTGTACCCTCTACGTCTAATTCAGACTGTGTTGCTGCTGATGAAGACGTTATTTACCATATCCAGTATGAT
GAATACCCAGAAAGCGGTACTCTAGAAATGAATGTCAAGGATCTTAGACCACGAGCTAGAACCATTTTGAAATGGAATGAACTAAATGTT
GGTGATGTGGTAATGGTTAATTATAATGTAGAAAGTCCTGGACAAAGAGGATTCTGGTTTGATGCAGAAATTACCACATTGAAGACAATC
TCAAGGACCAAAAAAGAACTTCGTGTGAAAATTTTCCTGGGGGGTTCTGAAGGAACATTAAATGACTGCAAGATAATATCTGTAGATGAA
ATCTTCAAGATTGAGAGACCTGGAGCCCATCCCCTTTCATTTGCAGATGGAAAGTTTTTAAGGCGAAATGACCCTGAATGTGACCTGTGT
GGTGGAGACCCAGAAAAGAAATGTCATTCTTGCTCCTGTCGTGTATGTGGTGGGAAACATGAACCCAACATGCAGCTTCTGTGTGATGAA
TGTAATGTGGCTTATCATATTTACTGTCTGAATCCACCTTTGGATAAAGTCCCAGAAGAGGAATACTGGTATTGTCCTTCTTGTAAAACT
GATTCCAGTGAAGTTGTAAAGGCTGGTGAAAGACTCAAGATGAGTAAAAAGAAAGCAAAGATGCCGTCAGCTAGTACTGAAAGCCGAAGA
GACTGGGGCAGGGGAATGGCTTGTGTTGGTCGTACGAGAGAATGTACTATTGTCCCTTCTAATCATTATGGACCCATTCCTGGTATTCCT
GTTGGATCAACTTGGAGATTTAGAGTTCAGGTGAGCGAAGCAGGTGTTCACAGACCCCATGTTGGTGGAATTCATGGTCGAAGTAATGAT
GGGGCTTATTCTCTTGTACTGGCTGGTGGATTTGCGGATGAAGTCGACCGAGGTGATGAGTTCACATACACTGGAAGCGGTGGTAAAAAT
CTTGCTGGTAACAAAAGAATTGGTGCACCTTCAGCTGATCAAACATTAACAAACATGAACAGGGCATTGGCCCTAAACTGTGATGCTCCA
TTGGATGATAAAATTGGAGCAGAGTCTCGGAATTGGAGAGCTGGTAAGCCAGTCAGAGTGATACGCAGTTTTAAAGGGAGGAAGATCAGC
AAATATGCTCCTGAAGAAGGCAACAGATATGATGGCATTTATAAGGTGGTGAAATACTGGCCAGAGATTTCATCAAGCCATGGATTCTTG
GTTTGGCGCTATCTTTTAAGAAGAGATGATGTTGAACCTGCTCCTTGGACCTCTGAAGGAATAGAACGGTCAAGGAGATTATGTCTACGT
TTACAGTATCCAGCAGGTTACCCTTCAGATAAAGAAGGGAAGAAGCCTAAAGGACAGTCAAAGAAGCAGCCCAGTGGAACCACAAAAAGG
CCAATTTCAGATGATGACTGTCCAAGTGCCTCCAAAGTGTACAAAGCATCAGATTCAGCAGAAGCAATTGAGGCTTTTCAACTAACTCCT
CAACAGCAACATCTCATCAGAGAAGATTGTCAAAACCAGAAGCTGTGGGATGAAGTGCTTTCACATCTTGTGGAAGGACCAAATTTTCTG
AAAAAATTGGAACAATCTTTTATGTGCGTTTGCTGTCAGGAGCTAGTTTACCAGCCTGTGACAACTGAGTGCTTCCACAATGTCTGTAAA
TTGGCCAGAATTACATCATGATTCCCAATGAGATTCTGCAGACTCTACTTGACCTTTTCTTCCCTGGCTACAGCAAAGGACGATGATCTG
CCTGCTTTCACTGTGTTGTTCATGGTGGCTTTTTGGACAATAAAGAATCTAAAATGGGTGGGGAGGGTGGAAGAAATGGTGGACTGTATC
TCTCACGTTCTGAAGCAGCTAATCCTCTTTCCCACATAGCCATCATCTTGTGTGTGTAGTAAGAGGCCCATTTCTCAACTGTCTTTTAAA
TATCTAAAGGTAGTTCCTGTAACAACTAGTTTTAATGAGTAAAAAGTCAAAGCCTCAGCTCTAGTTGATATCCAAGTTATGATTTATTTT
GCAACTACCTCAGGACAGAAAAGATTTATGGGGATTTTAAAAATCATTGAATAACTAGTTAAATGAAATTTTAGCTACACACTGCCTCCC
AAATATTAGTTGTGCCTGGTTCTTGTAATTTGATTTTACAGAAAAGGAAATGACACTTGAGATCCTTGGAATGAACACAGCTTCTAAAGT
GTGCATATACTTTTTTAACGTCTCTTCTTCCATTACAATGTGTGTTTTGCAAGGACAGGTTCATTTTTTTTAGCCCACTTTGTGAACTCC
ATTGTGCTTTTTTCTGGTGTTTTATGCAAGTTGACTACTAATGACTAATGAGAACAATAATGAATGCATTGTTGCTGCATTAGTGTAATG
TGGTGTGGTTTTGCACTTAAAAGAGGTATTCATATGCTCTAGTTGTAAATGTTCATGAAAATCCACTTCTCTACTAGTCGAACTGCTTTT
AGTGTCTCACCAGTGGTTTTACATCTGCAGAGTTTTGAGGGCTGTGCTGACCTTTGAGAGGATTTGAAATTGCTTCATATTGTGATCCTA
AATTTTATATTCACTATATTCCCTAAAGTATACCTTAATAAATATTTTATGATCAGAAAAACTGGCCAAGTTGGAAAAGTATTATTTGAA
GAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGT
GAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTT
ATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGAC
CTATCAGATTGGATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATT
TTTACCTTGTAAAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAAC
CCCATAGCACAACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAA
TCAACTGCATAAATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGA
CAAGAATAAAGTGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGG
CAATGTACAGAAATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACT
AAATGAAAAGTTAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTA
CAGACATGTTGAGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAA
AAGTGAATTTGATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGT
AATAGATGTAAGTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGT
TGTACAGGTGTACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACG
TCCCTGCCCTCTTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCT
TTATATGGTTTCAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGA
CCTGCTAGAATTTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGC
CAATGCTTTTTTCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAG
AGCAAATCTGTATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCC
CAACAATCTTTTTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAA
CTTGCTGTGTATATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCC
ACTTATGTTCAGTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAG
AAACGCAATCTTCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTT
GGGGATGCCAGGCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAAC
ACTTGTCACCGTTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAA
AACCCACACAAAGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGC
CCATGGTTTCAGGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCT
TGCCCTCTGTTGGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGG
GTCCTGATACTCATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGT
AGAAATTTTACAGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCA
CATTTCAGAATAAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTC
TAAGTCCTGGCTCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGA

>96735_96735_1_UHRF2-PUM2_UHRF2_chr9_6506093_ENST00000276893_PUM2_chr2_20451426_ENST00000319801_length(amino acids)=796AA_BP=
MPLRARAAGKAARAGRGAAPRAQGETKGTGSSLGAKMWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLEN
GYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWF
EAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRAR
TILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFL
RRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAK
MPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDE
FTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYW
PEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKASDSA

--------------------------------------------------------------
>96735_96735_2_UHRF2-PUM2_UHRF2_chr9_6506093_ENST00000276893_PUM2_chr2_20451426_ENST00000338086_length(transcript)=6366nt_BP=3391nt
AGAGTCGTCGCCGCCTGTCGGGCCCGGCGTCCGGTCGGTCCGGTGGGCGCGCTCGCCCGCCTGCCGCTGAGGGCCCGAGCCGCAGGGAAA
GCGGCGCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAG
GTTCGCACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCG
CTGTTCGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGA
CTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAAT
AGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTT
GGAATATATAAGGTAAATGAATTGGTGGATGCCAGAGATGTCGGCCTTGGTGCTTGGTTTGAAGCACACATACATAGTGTTACTAGAGCT
TCTGATGGACAGTCACGTGGCAAAACTCCACTGAAGAATGGCAGTTCTTGTAAAAGGACTAATGGAAATATAAAGCATAAATCCAAAGAG
AACACAAATAAATTGGACAGTGTACCCTCTACGTCTAATTCAGACTGTGTTGCTGCTGATGAAGACGTTATTTACCATATCCAGTATGAT
GAATACCCAGAAAGCGGTACTCTAGAAATGAATGTCAAGGATCTTAGACCACGAGCTAGAACCATTTTGAAATGGAATGAACTAAATGTT
GGTGATGTGGTAATGGTTAATTATAATGTAGAAAGTCCTGGACAAAGAGGATTCTGGTTTGATGCAGAAATTACCACATTGAAGACAATC
TCAAGGACCAAAAAAGAACTTCGTGTGAAAATTTTCCTGGGGGGTTCTGAAGGAACATTAAATGACTGCAAGATAATATCTGTAGATGAA
ATCTTCAAGATTGAGAGACCTGGAGCCCATCCCCTTTCATTTGCAGATGGAAAGTTTTTAAGGCGAAATGACCCTGAATGTGACCTGTGT
GGTGGAGACCCAGAAAAGAAATGTCATTCTTGCTCCTGTCGTGTATGTGGTGGGAAACATGAACCCAACATGCAGCTTCTGTGTGATGAA
TGTAATGTGGCTTATCATATTTACTGTCTGAATCCACCTTTGGATAAAGTCCCAGAAGAGGAATACTGGTATTGTCCTTCTTGTAAAACT
GATTCCAGTGAAGTTGTAAAGGCTGGTGAAAGACTCAAGATGAGTAAAAAGAAAGCAAAGATGCCGTCAGCTAGTACTGAAAGCCGAAGA
GACTGGGGCAGGGGAATGGCTTGTGTTGGTCGTACGAGAGAATGTACTATTGTCCCTTCTAATCATTATGGACCCATTCCTGGTATTCCT
GTTGGATCAACTTGGAGATTTAGAGTTCAGGTGAGCGAAGCAGGTGTTCACAGACCCCATGTTGGTGGAATTCATGGTCGAAGTAATGAT
GGGGCTTATTCTCTTGTACTGGCTGGTGGATTTGCGGATGAAGTCGACCGAGGTGATGAGTTCACATACACTGGAAGCGGTGGTAAAAAT
CTTGCTGGTAACAAAAGAATTGGTGCACCTTCAGCTGATCAAACATTAACAAACATGAACAGGGCATTGGCCCTAAACTGTGATGCTCCA
TTGGATGATAAAATTGGAGCAGAGTCTCGGAATTGGAGAGCTGGTAAGCCAGTCAGAGTGATACGCAGTTTTAAAGGGAGGAAGATCAGC
AAATATGCTCCTGAAGAAGGCAACAGATATGATGGCATTTATAAGGTGGTGAAATACTGGCCAGAGATTTCATCAAGCCATGGATTCTTG
GTTTGGCGCTATCTTTTAAGAAGAGATGATGTTGAACCTGCTCCTTGGACCTCTGAAGGAATAGAACGGTCAAGGAGATTATGTCTACGT
TTACAGTATCCAGCAGGTTACCCTTCAGATAAAGAAGGGAAGAAGCCTAAAGGACAGTCAAAGAAGCAGCCCAGTGGAACCACAAAAAGG
CCAATTTCAGATGATGACTGTCCAAGTGCCTCCAAAGTGTACAAAGCATCAGATTCAGCAGAAGCAATTGAGGCTTTTCAACTAACTCCT
CAACAGCAACATCTCATCAGAGAAGATTGTCAAAACCAGAAGCTGTGGGATGAAGTGCTTTCACATCTTGTGGAAGGACCAAATTTTCTG
AAAAAATTGGAACAATCTTTTATGTGCGTTTGCTGTCAGGAGCTAGTTTACCAGCCTGTGACAACTGAGTGCTTCCACAATGTCTGTAAA
TTGGCCAGAATTACATCATGATTCCCAATGAGATTCTGCAGACTCTACTTGACCTTTTCTTCCCTGGCTACAGCAAAGGACGATGATCTG
CCTGCTTTCACTGTGTTGTTCATGGTGGCTTTTTGGACAATAAAGAATCTAAAATGGGTGGGGAGGGTGGAAGAAATGGTGGACTGTATC
TCTCACGTTCTGAAGCAGCTAATCCTCTTTCCCACATAGCCATCATCTTGTGTGTGTAGTAAGAGGCCCATTTCTCAACTGTCTTTTAAA
TATCTAAAGGTAGTTCCTGTAACAACTAGTTTTAATGAGTAAAAAGTCAAAGCCTCAGCTCTAGTTGATATCCAAGTTATGATTTATTTT
GCAACTACCTCAGGACAGAAAAGATTTATGGGGATTTTAAAAATCATTGAATAACTAGTTAAATGAAATTTTAGCTACACACTGCCTCCC
AAATATTAGTTGTGCCTGGTTCTTGTAATTTGATTTTACAGAAAAGGAAATGACACTTGAGATCCTTGGAATGAACACAGCTTCTAAAGT
GTGCATATACTTTTTTAACGTCTCTTCTTCCATTACAATGTGTGTTTTGCAAGGACAGGTTCATTTTTTTTAGCCCACTTTGTGAACTCC
ATTGTGCTTTTTTCTGGTGTTTTATGCAAGTTGACTACTAATGACTAATGAGAACAATAATGAATGCATTGTTGCTGCATTAGTGTAATG
TGGTGTGGTTTTGCACTTAAAAGAGGTATTCATATGCTCTAGTTGTAAATGTTCATGAAAATCCACTTCTCTACTAGTCGAACTGCTTTT
AGTGTCTCACCAGTGGTTTTACATCTGCAGAGTTTTGAGGGCTGTGCTGACCTTTGAGAGGATTTGAAATTGCTTCATATTGTGATCCTA
AATTTTATATTCACTATATTCCCTAAAGTATACCTTAATAAATATTTTATGATCAGAAAAACTGGCCAAGTTGGAAAAGTATTATTTGAA
GAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGT
GAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTT
ATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGAC
CTATCAGATTGGATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATT
TTTACCTTGTAAAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAAC
CCCATAGCACAACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAA
TCAACTGCATAAATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGA
CAAGAATAAAGTGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGG
CAATGTACAGAAATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACT
AAATGAAAAGTTAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTA
CAGACATGTTGAGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAA
AAGTGAATTTGATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGT
AATAGATGTAAGTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGT
TGTACAGGTGTACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACG
TCCCTGCCCTCTTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCT
TTATATGGTTTCAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGA
CCTGCTAGAATTTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGC
CAATGCTTTTTTCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAG
AGCAAATCTGTATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCC
CAACAATCTTTTTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAA
CTTGCTGTGTATATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCC
ACTTATGTTCAGTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAG
AAACGCAATCTTCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTT
GGGGATGCCAGGCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAAC
ACTTGTCACCGTTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAA
AACCCACACAAAGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGC
CCATGGTTTCAGGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCT
TGCCCTCTGTTGGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGG
GTCCTGATACTCATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGT
AGAAATTTTACAGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCA
CATTTCAGAATAAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTC
TAAGTCCTGGCTCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGA

>96735_96735_2_UHRF2-PUM2_UHRF2_chr9_6506093_ENST00000276893_PUM2_chr2_20451426_ENST00000338086_length(amino acids)=796AA_BP=
MPLRARAAGKAARAGRGAAPRAQGETKGTGSSLGAKMWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLEN
GYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWF
EAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRAR
TILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFL
RRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAK
MPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDE
FTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYW
PEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKASDSA

--------------------------------------------------------------
>96735_96735_3_UHRF2-PUM2_UHRF2_chr9_6506093_ENST00000276893_PUM2_chr2_20451426_ENST00000361078_length(transcript)=6365nt_BP=3391nt
AGAGTCGTCGCCGCCTGTCGGGCCCGGCGTCCGGTCGGTCCGGTGGGCGCGCTCGCCCGCCTGCCGCTGAGGGCCCGAGCCGCAGGGAAA
GCGGCGCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAG
GTTCGCACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCG
CTGTTCGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGA
CTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAAT
AGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTT
GGAATATATAAGGTAAATGAATTGGTGGATGCCAGAGATGTCGGCCTTGGTGCTTGGTTTGAAGCACACATACATAGTGTTACTAGAGCT
TCTGATGGACAGTCACGTGGCAAAACTCCACTGAAGAATGGCAGTTCTTGTAAAAGGACTAATGGAAATATAAAGCATAAATCCAAAGAG
AACACAAATAAATTGGACAGTGTACCCTCTACGTCTAATTCAGACTGTGTTGCTGCTGATGAAGACGTTATTTACCATATCCAGTATGAT
GAATACCCAGAAAGCGGTACTCTAGAAATGAATGTCAAGGATCTTAGACCACGAGCTAGAACCATTTTGAAATGGAATGAACTAAATGTT
GGTGATGTGGTAATGGTTAATTATAATGTAGAAAGTCCTGGACAAAGAGGATTCTGGTTTGATGCAGAAATTACCACATTGAAGACAATC
TCAAGGACCAAAAAAGAACTTCGTGTGAAAATTTTCCTGGGGGGTTCTGAAGGAACATTAAATGACTGCAAGATAATATCTGTAGATGAA
ATCTTCAAGATTGAGAGACCTGGAGCCCATCCCCTTTCATTTGCAGATGGAAAGTTTTTAAGGCGAAATGACCCTGAATGTGACCTGTGT
GGTGGAGACCCAGAAAAGAAATGTCATTCTTGCTCCTGTCGTGTATGTGGTGGGAAACATGAACCCAACATGCAGCTTCTGTGTGATGAA
TGTAATGTGGCTTATCATATTTACTGTCTGAATCCACCTTTGGATAAAGTCCCAGAAGAGGAATACTGGTATTGTCCTTCTTGTAAAACT
GATTCCAGTGAAGTTGTAAAGGCTGGTGAAAGACTCAAGATGAGTAAAAAGAAAGCAAAGATGCCGTCAGCTAGTACTGAAAGCCGAAGA
GACTGGGGCAGGGGAATGGCTTGTGTTGGTCGTACGAGAGAATGTACTATTGTCCCTTCTAATCATTATGGACCCATTCCTGGTATTCCT
GTTGGATCAACTTGGAGATTTAGAGTTCAGGTGAGCGAAGCAGGTGTTCACAGACCCCATGTTGGTGGAATTCATGGTCGAAGTAATGAT
GGGGCTTATTCTCTTGTACTGGCTGGTGGATTTGCGGATGAAGTCGACCGAGGTGATGAGTTCACATACACTGGAAGCGGTGGTAAAAAT
CTTGCTGGTAACAAAAGAATTGGTGCACCTTCAGCTGATCAAACATTAACAAACATGAACAGGGCATTGGCCCTAAACTGTGATGCTCCA
TTGGATGATAAAATTGGAGCAGAGTCTCGGAATTGGAGAGCTGGTAAGCCAGTCAGAGTGATACGCAGTTTTAAAGGGAGGAAGATCAGC
AAATATGCTCCTGAAGAAGGCAACAGATATGATGGCATTTATAAGGTGGTGAAATACTGGCCAGAGATTTCATCAAGCCATGGATTCTTG
GTTTGGCGCTATCTTTTAAGAAGAGATGATGTTGAACCTGCTCCTTGGACCTCTGAAGGAATAGAACGGTCAAGGAGATTATGTCTACGT
TTACAGTATCCAGCAGGTTACCCTTCAGATAAAGAAGGGAAGAAGCCTAAAGGACAGTCAAAGAAGCAGCCCAGTGGAACCACAAAAAGG
CCAATTTCAGATGATGACTGTCCAAGTGCCTCCAAAGTGTACAAAGCATCAGATTCAGCAGAAGCAATTGAGGCTTTTCAACTAACTCCT
CAACAGCAACATCTCATCAGAGAAGATTGTCAAAACCAGAAGCTGTGGGATGAAGTGCTTTCACATCTTGTGGAAGGACCAAATTTTCTG
AAAAAATTGGAACAATCTTTTATGTGCGTTTGCTGTCAGGAGCTAGTTTACCAGCCTGTGACAACTGAGTGCTTCCACAATGTCTGTAAA
TTGGCCAGAATTACATCATGATTCCCAATGAGATTCTGCAGACTCTACTTGACCTTTTCTTCCCTGGCTACAGCAAAGGACGATGATCTG
CCTGCTTTCACTGTGTTGTTCATGGTGGCTTTTTGGACAATAAAGAATCTAAAATGGGTGGGGAGGGTGGAAGAAATGGTGGACTGTATC
TCTCACGTTCTGAAGCAGCTAATCCTCTTTCCCACATAGCCATCATCTTGTGTGTGTAGTAAGAGGCCCATTTCTCAACTGTCTTTTAAA
TATCTAAAGGTAGTTCCTGTAACAACTAGTTTTAATGAGTAAAAAGTCAAAGCCTCAGCTCTAGTTGATATCCAAGTTATGATTTATTTT
GCAACTACCTCAGGACAGAAAAGATTTATGGGGATTTTAAAAATCATTGAATAACTAGTTAAATGAAATTTTAGCTACACACTGCCTCCC
AAATATTAGTTGTGCCTGGTTCTTGTAATTTGATTTTACAGAAAAGGAAATGACACTTGAGATCCTTGGAATGAACACAGCTTCTAAAGT
GTGCATATACTTTTTTAACGTCTCTTCTTCCATTACAATGTGTGTTTTGCAAGGACAGGTTCATTTTTTTTAGCCCACTTTGTGAACTCC
ATTGTGCTTTTTTCTGGTGTTTTATGCAAGTTGACTACTAATGACTAATGAGAACAATAATGAATGCATTGTTGCTGCATTAGTGTAATG
TGGTGTGGTTTTGCACTTAAAAGAGGTATTCATATGCTCTAGTTGTAAATGTTCATGAAAATCCACTTCTCTACTAGTCGAACTGCTTTT
AGTGTCTCACCAGTGGTTTTACATCTGCAGAGTTTTGAGGGCTGTGCTGACCTTTGAGAGGATTTGAAATTGCTTCATATTGTGATCCTA
AATTTTATATTCACTATATTCCCTAAAGTATACCTTAATAAATATTTTATGATCAGAAAAACTGGCCAAGTTGGAAAAGTATTATTTGAA
GAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGT
GAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTT
ATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGAC
CTATCAGATTGGATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATT
TTTACCTTGTAAAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAAC
CCCATAGCACAACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAA
TCAACTGCATAAATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGA
CAAGAATAAAGTGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGG
CAATGTACAGAAATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACT
AAATGAAAAGTTAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTA
CAGACATGTTGAGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAA
AAGTGAATTTGATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGT
AATAGATGTAAGTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGT
TGTACAGGTGTACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACG
TCCCTGCCCTCTTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCT
TTATATGGTTTCAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGA
CCTGCTAGAATTTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGC
CAATGCTTTTTTCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAG
AGCAAATCTGTATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCC
CAACAATCTTTTTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAA
CTTGCTGTGTATATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCC
ACTTATGTTCAGTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAG
AAACGCAATCTTCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTT
GGGGATGCCAGGCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAAC
ACTTGTCACCGTTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAA
AACCCACACAAAGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGC
CCATGGTTTCAGGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCT
TGCCCTCTGTTGGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGG
GTCCTGATACTCATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGT
AGAAATTTTACAGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCA
CATTTCAGAATAAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTC
TAAGTCCTGGCTCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGA

>96735_96735_3_UHRF2-PUM2_UHRF2_chr9_6506093_ENST00000276893_PUM2_chr2_20451426_ENST00000361078_length(amino acids)=796AA_BP=
MPLRARAAGKAARAGRGAAPRAQGETKGTGSSLGAKMWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLEN
GYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWF
EAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRAR
TILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFL
RRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAK
MPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDE
FTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYW
PEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKASDSA

--------------------------------------------------------------
>96735_96735_4_UHRF2-PUM2_UHRF2_chr9_6506093_ENST00000276893_PUM2_chr2_20451426_ENST00000403432_length(transcript)=3747nt_BP=3391nt
AGAGTCGTCGCCGCCTGTCGGGCCCGGCGTCCGGTCGGTCCGGTGGGCGCGCTCGCCCGCCTGCCGCTGAGGGCCCGAGCCGCAGGGAAA
GCGGCGCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAG
GTTCGCACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCG
CTGTTCGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGA
CTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAAT
AGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTT
GGAATATATAAGGTAAATGAATTGGTGGATGCCAGAGATGTCGGCCTTGGTGCTTGGTTTGAAGCACACATACATAGTGTTACTAGAGCT
TCTGATGGACAGTCACGTGGCAAAACTCCACTGAAGAATGGCAGTTCTTGTAAAAGGACTAATGGAAATATAAAGCATAAATCCAAAGAG
AACACAAATAAATTGGACAGTGTACCCTCTACGTCTAATTCAGACTGTGTTGCTGCTGATGAAGACGTTATTTACCATATCCAGTATGAT
GAATACCCAGAAAGCGGTACTCTAGAAATGAATGTCAAGGATCTTAGACCACGAGCTAGAACCATTTTGAAATGGAATGAACTAAATGTT
GGTGATGTGGTAATGGTTAATTATAATGTAGAAAGTCCTGGACAAAGAGGATTCTGGTTTGATGCAGAAATTACCACATTGAAGACAATC
TCAAGGACCAAAAAAGAACTTCGTGTGAAAATTTTCCTGGGGGGTTCTGAAGGAACATTAAATGACTGCAAGATAATATCTGTAGATGAA
ATCTTCAAGATTGAGAGACCTGGAGCCCATCCCCTTTCATTTGCAGATGGAAAGTTTTTAAGGCGAAATGACCCTGAATGTGACCTGTGT
GGTGGAGACCCAGAAAAGAAATGTCATTCTTGCTCCTGTCGTGTATGTGGTGGGAAACATGAACCCAACATGCAGCTTCTGTGTGATGAA
TGTAATGTGGCTTATCATATTTACTGTCTGAATCCACCTTTGGATAAAGTCCCAGAAGAGGAATACTGGTATTGTCCTTCTTGTAAAACT
GATTCCAGTGAAGTTGTAAAGGCTGGTGAAAGACTCAAGATGAGTAAAAAGAAAGCAAAGATGCCGTCAGCTAGTACTGAAAGCCGAAGA
GACTGGGGCAGGGGAATGGCTTGTGTTGGTCGTACGAGAGAATGTACTATTGTCCCTTCTAATCATTATGGACCCATTCCTGGTATTCCT
GTTGGATCAACTTGGAGATTTAGAGTTCAGGTGAGCGAAGCAGGTGTTCACAGACCCCATGTTGGTGGAATTCATGGTCGAAGTAATGAT
GGGGCTTATTCTCTTGTACTGGCTGGTGGATTTGCGGATGAAGTCGACCGAGGTGATGAGTTCACATACACTGGAAGCGGTGGTAAAAAT
CTTGCTGGTAACAAAAGAATTGGTGCACCTTCAGCTGATCAAACATTAACAAACATGAACAGGGCATTGGCCCTAAACTGTGATGCTCCA
TTGGATGATAAAATTGGAGCAGAGTCTCGGAATTGGAGAGCTGGTAAGCCAGTCAGAGTGATACGCAGTTTTAAAGGGAGGAAGATCAGC
AAATATGCTCCTGAAGAAGGCAACAGATATGATGGCATTTATAAGGTGGTGAAATACTGGCCAGAGATTTCATCAAGCCATGGATTCTTG
GTTTGGCGCTATCTTTTAAGAAGAGATGATGTTGAACCTGCTCCTTGGACCTCTGAAGGAATAGAACGGTCAAGGAGATTATGTCTACGT
TTACAGTATCCAGCAGGTTACCCTTCAGATAAAGAAGGGAAGAAGCCTAAAGGACAGTCAAAGAAGCAGCCCAGTGGAACCACAAAAAGG
CCAATTTCAGATGATGACTGTCCAAGTGCCTCCAAAGTGTACAAAGCATCAGATTCAGCAGAAGCAATTGAGGCTTTTCAACTAACTCCT
CAACAGCAACATCTCATCAGAGAAGATTGTCAAAACCAGAAGCTGTGGGATGAAGTGCTTTCACATCTTGTGGAAGGACCAAATTTTCTG
AAAAAATTGGAACAATCTTTTATGTGCGTTTGCTGTCAGGAGCTAGTTTACCAGCCTGTGACAACTGAGTGCTTCCACAATGTCTGTAAA
TTGGCCAGAATTACATCATGATTCCCAATGAGATTCTGCAGACTCTACTTGACCTTTTCTTCCCTGGCTACAGCAAAGGACGATGATCTG
CCTGCTTTCACTGTGTTGTTCATGGTGGCTTTTTGGACAATAAAGAATCTAAAATGGGTGGGGAGGGTGGAAGAAATGGTGGACTGTATC
TCTCACGTTCTGAAGCAGCTAATCCTCTTTCCCACATAGCCATCATCTTGTGTGTGTAGTAAGAGGCCCATTTCTCAACTGTCTTTTAAA
TATCTAAAGGTAGTTCCTGTAACAACTAGTTTTAATGAGTAAAAAGTCAAAGCCTCAGCTCTAGTTGATATCCAAGTTATGATTTATTTT
GCAACTACCTCAGGACAGAAAAGATTTATGGGGATTTTAAAAATCATTGAATAACTAGTTAAATGAAATTTTAGCTACACACTGCCTCCC
AAATATTAGTTGTGCCTGGTTCTTGTAATTTGATTTTACAGAAAAGGAAATGACACTTGAGATCCTTGGAATGAACACAGCTTCTAAAGT
GTGCATATACTTTTTTAACGTCTCTTCTTCCATTACAATGTGTGTTTTGCAAGGACAGGTTCATTTTTTTTAGCCCACTTTGTGAACTCC
ATTGTGCTTTTTTCTGGTGTTTTATGCAAGTTGACTACTAATGACTAATGAGAACAATAATGAATGCATTGTTGCTGCATTAGTGTAATG
TGGTGTGGTTTTGCACTTAAAAGAGGTATTCATATGCTCTAGTTGTAAATGTTCATGAAAATCCACTTCTCTACTAGTCGAACTGCTTTT
AGTGTCTCACCAGTGGTTTTACATCTGCAGAGTTTTGAGGGCTGTGCTGACCTTTGAGAGGATTTGAAATTGCTTCATATTGTGATCCTA
AATTTTATATTCACTATATTCCCTAAAGTATACCTTAATAAATATTTTATGATCAGAAAAACTGGCCAAGTTGGAAAAGTATTATTTGAA
GAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGT
GAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTT
ATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGAC

>96735_96735_4_UHRF2-PUM2_UHRF2_chr9_6506093_ENST00000276893_PUM2_chr2_20451426_ENST00000403432_length(amino acids)=796AA_BP=
MPLRARAAGKAARAGRGAAPRAQGETKGTGSSLGAKMWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLEN
GYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWF
EAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRAR
TILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFL
RRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAK
MPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDE
FTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYW
PEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKASDSA

--------------------------------------------------------------
>96735_96735_5_UHRF2-PUM2_UHRF2_chr9_6506093_ENST00000276893_PUM2_chr2_20451426_ENST00000536417_length(transcript)=3747nt_BP=3391nt
AGAGTCGTCGCCGCCTGTCGGGCCCGGCGTCCGGTCGGTCCGGTGGGCGCGCTCGCCCGCCTGCCGCTGAGGGCCCGAGCCGCAGGGAAA
GCGGCGCGGGCCGGGCGGGGCGCGGCGCCCAGAGCTCAGGGGGAGACAAAGGGGACCGGTTCCTCTCTAGGCGCCAAGATGTGGATACAG
GTTCGCACCATTGATGGCTCCAAGACGTGCACCATTGAGGACGTGTCTCGCAAAGCCACGATTGAGGAGCTGCGCGAGCGGGTGTGGGCG
CTGTTCGACGTGCGGCCCGAATGCCAGCGCCTCTTCTACCGGGGCAAGCAGTTGGAAAATGGATATACCTTATTTGATTATGATGTTGGA
CTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTAAT
AGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTT
GGAATATATAAGGTAAATGAATTGGTGGATGCCAGAGATGTCGGCCTTGGTGCTTGGTTTGAAGCACACATACATAGTGTTACTAGAGCT
TCTGATGGACAGTCACGTGGCAAAACTCCACTGAAGAATGGCAGTTCTTGTAAAAGGACTAATGGAAATATAAAGCATAAATCCAAAGAG
AACACAAATAAATTGGACAGTGTACCCTCTACGTCTAATTCAGACTGTGTTGCTGCTGATGAAGACGTTATTTACCATATCCAGTATGAT
GAATACCCAGAAAGCGGTACTCTAGAAATGAATGTCAAGGATCTTAGACCACGAGCTAGAACCATTTTGAAATGGAATGAACTAAATGTT
GGTGATGTGGTAATGGTTAATTATAATGTAGAAAGTCCTGGACAAAGAGGATTCTGGTTTGATGCAGAAATTACCACATTGAAGACAATC
TCAAGGACCAAAAAAGAACTTCGTGTGAAAATTTTCCTGGGGGGTTCTGAAGGAACATTAAATGACTGCAAGATAATATCTGTAGATGAA
ATCTTCAAGATTGAGAGACCTGGAGCCCATCCCCTTTCATTTGCAGATGGAAAGTTTTTAAGGCGAAATGACCCTGAATGTGACCTGTGT
GGTGGAGACCCAGAAAAGAAATGTCATTCTTGCTCCTGTCGTGTATGTGGTGGGAAACATGAACCCAACATGCAGCTTCTGTGTGATGAA
TGTAATGTGGCTTATCATATTTACTGTCTGAATCCACCTTTGGATAAAGTCCCAGAAGAGGAATACTGGTATTGTCCTTCTTGTAAAACT
GATTCCAGTGAAGTTGTAAAGGCTGGTGAAAGACTCAAGATGAGTAAAAAGAAAGCAAAGATGCCGTCAGCTAGTACTGAAAGCCGAAGA
GACTGGGGCAGGGGAATGGCTTGTGTTGGTCGTACGAGAGAATGTACTATTGTCCCTTCTAATCATTATGGACCCATTCCTGGTATTCCT
GTTGGATCAACTTGGAGATTTAGAGTTCAGGTGAGCGAAGCAGGTGTTCACAGACCCCATGTTGGTGGAATTCATGGTCGAAGTAATGAT
GGGGCTTATTCTCTTGTACTGGCTGGTGGATTTGCGGATGAAGTCGACCGAGGTGATGAGTTCACATACACTGGAAGCGGTGGTAAAAAT
CTTGCTGGTAACAAAAGAATTGGTGCACCTTCAGCTGATCAAACATTAACAAACATGAACAGGGCATTGGCCCTAAACTGTGATGCTCCA
TTGGATGATAAAATTGGAGCAGAGTCTCGGAATTGGAGAGCTGGTAAGCCAGTCAGAGTGATACGCAGTTTTAAAGGGAGGAAGATCAGC
AAATATGCTCCTGAAGAAGGCAACAGATATGATGGCATTTATAAGGTGGTGAAATACTGGCCAGAGATTTCATCAAGCCATGGATTCTTG
GTTTGGCGCTATCTTTTAAGAAGAGATGATGTTGAACCTGCTCCTTGGACCTCTGAAGGAATAGAACGGTCAAGGAGATTATGTCTACGT
TTACAGTATCCAGCAGGTTACCCTTCAGATAAAGAAGGGAAGAAGCCTAAAGGACAGTCAAAGAAGCAGCCCAGTGGAACCACAAAAAGG
CCAATTTCAGATGATGACTGTCCAAGTGCCTCCAAAGTGTACAAAGCATCAGATTCAGCAGAAGCAATTGAGGCTTTTCAACTAACTCCT
CAACAGCAACATCTCATCAGAGAAGATTGTCAAAACCAGAAGCTGTGGGATGAAGTGCTTTCACATCTTGTGGAAGGACCAAATTTTCTG
AAAAAATTGGAACAATCTTTTATGTGCGTTTGCTGTCAGGAGCTAGTTTACCAGCCTGTGACAACTGAGTGCTTCCACAATGTCTGTAAA
TTGGCCAGAATTACATCATGATTCCCAATGAGATTCTGCAGACTCTACTTGACCTTTTCTTCCCTGGCTACAGCAAAGGACGATGATCTG
CCTGCTTTCACTGTGTTGTTCATGGTGGCTTTTTGGACAATAAAGAATCTAAAATGGGTGGGGAGGGTGGAAGAAATGGTGGACTGTATC
TCTCACGTTCTGAAGCAGCTAATCCTCTTTCCCACATAGCCATCATCTTGTGTGTGTAGTAAGAGGCCCATTTCTCAACTGTCTTTTAAA
TATCTAAAGGTAGTTCCTGTAACAACTAGTTTTAATGAGTAAAAAGTCAAAGCCTCAGCTCTAGTTGATATCCAAGTTATGATTTATTTT
GCAACTACCTCAGGACAGAAAAGATTTATGGGGATTTTAAAAATCATTGAATAACTAGTTAAATGAAATTTTAGCTACACACTGCCTCCC
AAATATTAGTTGTGCCTGGTTCTTGTAATTTGATTTTACAGAAAAGGAAATGACACTTGAGATCCTTGGAATGAACACAGCTTCTAAAGT
GTGCATATACTTTTTTAACGTCTCTTCTTCCATTACAATGTGTGTTTTGCAAGGACAGGTTCATTTTTTTTAGCCCACTTTGTGAACTCC
ATTGTGCTTTTTTCTGGTGTTTTATGCAAGTTGACTACTAATGACTAATGAGAACAATAATGAATGCATTGTTGCTGCATTAGTGTAATG
TGGTGTGGTTTTGCACTTAAAAGAGGTATTCATATGCTCTAGTTGTAAATGTTCATGAAAATCCACTTCTCTACTAGTCGAACTGCTTTT
AGTGTCTCACCAGTGGTTTTACATCTGCAGAGTTTTGAGGGCTGTGCTGACCTTTGAGAGGATTTGAAATTGCTTCATATTGTGATCCTA
AATTTTATATTCACTATATTCCCTAAAGTATACCTTAATAAATATTTTATGATCAGAAAAACTGGCCAAGTTGGAAAAGTATTATTTGAA
GAATAGCCCGGACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGT
GAAAAGAATTTTTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTT
ATTCATCCATTTGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGAC

>96735_96735_5_UHRF2-PUM2_UHRF2_chr9_6506093_ENST00000276893_PUM2_chr2_20451426_ENST00000536417_length(amino acids)=796AA_BP=
MPLRARAAGKAARAGRGAAPRAQGETKGTGSSLGAKMWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLEN
GYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWF
EAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRAR
TILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFL
RRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAK
MPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRGDE
FTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYW
PEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKASDSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for UHRF2-PUM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePUM2chr9:6506093chr2:20451426ENST000003198010191_2600988.0SNAPIN
TgenePUM2chr9:6506093chr2:20451426ENST000003380860201_26001065.0SNAPIN
TgenePUM2chr9:6506093chr2:20451426ENST000003610780201_26001067.0SNAPIN
TgenePUM2chr9:6506093chr2:20451426ENST000004034320211_26001065.0SNAPIN


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneUHRF2chr9:6506093chr2:20451426ENST00000276893-116194_2880803.0PCNP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UHRF2-PUM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UHRF2-PUM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource