FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ULK1-FBXW8 (FusionGDB2 ID:96750)

Fusion Gene Summary for ULK1-FBXW8

check button Fusion gene summary
Fusion gene informationFusion gene name: ULK1-FBXW8
Fusion gene ID: 96750
HgeneTgene
Gene symbol

ULK1

FBXW8

Gene ID

8408

26259

Gene nameunc-51 like autophagy activating kinase 1F-box and WD repeat domain containing 8
SynonymsATG1|ATG1A|UNC51|Unc51.1|hATG1FBW6|FBW8|FBX29|FBXO29|FBXW6
Cytomap

12q24.33

12q24.22

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase ULK1ATG1 autophagy related 1 homologautophagy-related protein 1 homologF-box/WD repeat-containing protein 8F-box and WD-40 domain protein 8F-box and WD-40 domain-containing protein 8F-box only protein 29
Modification date2020032720200313
UniProtAcc.

Q8N3Y1

Ensembl transtripts involved in fusion geneENST00000321867, ENST00000540647, 
ENST00000551773, ENST00000309909, 
ENST00000455858, 
Fusion gene scores* DoF score8 X 9 X 7=50412 X 12 X 4=576
# samples 1114
** MAII scorelog2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/576*10)=-2.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ULK1 [Title/Abstract] AND FBXW8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointULK1(132403929)-FBXW8(117461952), # samples:3
Anticipated loss of major functional domain due to fusion event.ULK1-FBXW8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ULK1-FBXW8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ULK1-FBXW8 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ULK1-FBXW8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneULK1

GO:0006914

autophagy

18936157

HgeneULK1

GO:0018105

peptidyl-serine phosphorylation

25126726|27103069

HgeneULK1

GO:0018107

peptidyl-threonine phosphorylation

27103069

HgeneULK1

GO:0031333

negative regulation of protein complex assembly

25126726

HgeneULK1

GO:0046777

protein autophosphorylation

18936157

TgeneFBXW8

GO:0008283

cell proliferation

24362026

TgeneFBXW8

GO:0016567

protein ubiquitination

18498745|24362026

TgeneFBXW8

GO:0050775

positive regulation of dendrite morphogenesis

21572988


check buttonFusion gene breakpoints across ULK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBXW8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-34-5232-01AULK1chr12

132403929

-FBXW8chr12

117461952

+
ChimerDB4LUSCTCGA-34-5232-01AULK1chr12

132403929

+FBXW8chr12

117461952

+
ChimerDB4LUSCTCGA-34-5232ULK1chr12

132402099

+FBXW8chr12

117461952

+
ChimerDB4LUSCTCGA-34-5232ULK1chr12

132403929

+FBXW8chr12

117461951

+
ChimerDB4LUSCTCGA-34-5232ULK1chr12

132403929

+FBXW8chr12

117461952

+
ChimerDB4LUSCTCGA-34-5232ULK1chr12

132404135

+FBXW8chr12

117461952

+


Top

Fusion Gene ORF analysis for ULK1-FBXW8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000321867ENST00000551773ULK1chr12

132403929

+FBXW8chr12

117461952

+
5CDS-intronENST00000321867ENST00000551773ULK1chr12

132402099

+FBXW8chr12

117461952

+
5CDS-intronENST00000321867ENST00000551773ULK1chr12

132403929

+FBXW8chr12

117461951

+
5CDS-intronENST00000321867ENST00000551773ULK1chr12

132404135

+FBXW8chr12

117461952

+
5CDS-intronENST00000540647ENST00000551773ULK1chr12

132403929

+FBXW8chr12

117461952

+
5CDS-intronENST00000540647ENST00000551773ULK1chr12

132403929

+FBXW8chr12

117461951

+
5CDS-intronENST00000540647ENST00000551773ULK1chr12

132404135

+FBXW8chr12

117461952

+
Frame-shiftENST00000321867ENST00000309909ULK1chr12

132402099

+FBXW8chr12

117461952

+
Frame-shiftENST00000321867ENST00000309909ULK1chr12

132404135

+FBXW8chr12

117461952

+
Frame-shiftENST00000321867ENST00000455858ULK1chr12

132402099

+FBXW8chr12

117461952

+
Frame-shiftENST00000321867ENST00000455858ULK1chr12

132404135

+FBXW8chr12

117461952

+
Frame-shiftENST00000540647ENST00000309909ULK1chr12

132404135

+FBXW8chr12

117461952

+
Frame-shiftENST00000540647ENST00000455858ULK1chr12

132404135

+FBXW8chr12

117461952

+
In-frameENST00000321867ENST00000309909ULK1chr12

132403929

+FBXW8chr12

117461952

+
In-frameENST00000321867ENST00000309909ULK1chr12

132403929

+FBXW8chr12

117461951

+
In-frameENST00000321867ENST00000455858ULK1chr12

132403929

+FBXW8chr12

117461952

+
In-frameENST00000321867ENST00000455858ULK1chr12

132403929

+FBXW8chr12

117461951

+
In-frameENST00000540647ENST00000309909ULK1chr12

132403929

+FBXW8chr12

117461952

+
In-frameENST00000540647ENST00000309909ULK1chr12

132403929

+FBXW8chr12

117461951

+
In-frameENST00000540647ENST00000455858ULK1chr12

132403929

+FBXW8chr12

117461952

+
In-frameENST00000540647ENST00000455858ULK1chr12

132403929

+FBXW8chr12

117461951

+
intron-3CDSENST00000540647ENST00000309909ULK1chr12

132402099

+FBXW8chr12

117461952

+
intron-3CDSENST00000540647ENST00000455858ULK1chr12

132402099

+FBXW8chr12

117461952

+
intron-intronENST00000540647ENST00000551773ULK1chr12

132402099

+FBXW8chr12

117461952

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321867ULK1chr12132403929+ENST00000309909FBXW8chr12117461952+3929303517434641096
ENST00000321867ULK1chr12132403929+ENST00000455858FBXW8chr12117461952+6441303517434641096
ENST00000540647ULK1chr12132403929+ENST00000309909FBXW8chr12117461952+144755365982305
ENST00000540647ULK1chr12132403929+ENST00000455858FBXW8chr12117461952+395955365982305
ENST00000321867ULK1chr12132403929+ENST00000309909FBXW8chr12117461951+3929303517434641096
ENST00000321867ULK1chr12132403929+ENST00000455858FBXW8chr12117461951+6441303517434641096
ENST00000540647ULK1chr12132403929+ENST00000309909FBXW8chr12117461951+144755365982305
ENST00000540647ULK1chr12132403929+ENST00000455858FBXW8chr12117461951+395955365982305

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321867ENST00000309909ULK1chr12132403929+FBXW8chr12117461952+0.0109887510.98901117
ENST00000321867ENST00000455858ULK1chr12132403929+FBXW8chr12117461952+0.0041421430.9958579
ENST00000540647ENST00000309909ULK1chr12132403929+FBXW8chr12117461952+0.111455040.8885449
ENST00000540647ENST00000455858ULK1chr12132403929+FBXW8chr12117461952+0.050796840.9492032
ENST00000321867ENST00000309909ULK1chr12132403929+FBXW8chr12117461951+0.0109887510.98901117
ENST00000321867ENST00000455858ULK1chr12132403929+FBXW8chr12117461951+0.0041421430.9958579
ENST00000540647ENST00000309909ULK1chr12132403929+FBXW8chr12117461951+0.111455040.8885449
ENST00000540647ENST00000455858ULK1chr12132403929+FBXW8chr12117461951+0.050796840.9492032

Top

Fusion Genomic Features for ULK1-FBXW8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ULK1chr12132402099+FBXW8chr12117461951+0.0011570870.99884284
ULK1chr12132403929+FBXW8chr12117461951+0.0008817620.99911827
ULK1chr12132403929+FBXW8chr12117461951+0.0008817620.99911827
ULK1chr12132404135+FBXW8chr12117461951+2.42E-060.9999976
ULK1chr12132402099+FBXW8chr12117461951+0.0011570870.99884284
ULK1chr12132403929+FBXW8chr12117461951+0.0008817620.99911827
ULK1chr12132403929+FBXW8chr12117461951+0.0008817620.99911827
ULK1chr12132404135+FBXW8chr12117461951+2.42E-060.9999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ULK1-FBXW8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:132403929/chr12:117461952)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FBXW8

Q8N3Y1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). {ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026, ECO:0000269|PubMed:24793695}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneULK1chr12:132403929chr12:117461951ENST00000321867+2428297_3108941051.0Compositional biasNote=Poly-Ser
HgeneULK1chr12:132403929chr12:117461952ENST00000321867+2428297_3108941051.0Compositional biasNote=Poly-Ser
HgeneULK1chr12:132403929chr12:117461951ENST00000321867+242816_2788941051.0DomainProtein kinase
HgeneULK1chr12:132403929chr12:117461952ENST00000321867+242816_2788941051.0DomainProtein kinase
HgeneULK1chr12:132403929chr12:117461951ENST00000321867+242822_308941051.0Nucleotide bindingATP
HgeneULK1chr12:132403929chr12:117461952ENST00000321867+242822_308941051.0Nucleotide bindingATP
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711473_510455599.0RepeatNote=WD 5
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711430_470389533.0RepeatNote=WD 4
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711473_510389533.0RepeatNote=WD 5
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711473_510455599.0RepeatNote=WD 5
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711430_470389533.0RepeatNote=WD 4
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711473_510389533.0RepeatNote=WD 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711113_159455599.0DomainF-box
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711113_159389533.0DomainF-box
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711113_159455599.0DomainF-box
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711113_159389533.0DomainF-box
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711197_245455599.0RepeatNote=WD 1
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711254_294455599.0RepeatNote=WD 2
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711297_336455599.0RepeatNote=WD 3
TgeneFBXW8chr12:132403929chr12:117461951ENST00000309909711430_470455599.0RepeatNote=WD 4
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711197_245389533.0RepeatNote=WD 1
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711254_294389533.0RepeatNote=WD 2
TgeneFBXW8chr12:132403929chr12:117461951ENST00000455858711297_336389533.0RepeatNote=WD 3
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711197_245455599.0RepeatNote=WD 1
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711254_294455599.0RepeatNote=WD 2
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711297_336455599.0RepeatNote=WD 3
TgeneFBXW8chr12:132403929chr12:117461952ENST00000309909711430_470455599.0RepeatNote=WD 4
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711197_245389533.0RepeatNote=WD 1
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711254_294389533.0RepeatNote=WD 2
TgeneFBXW8chr12:132403929chr12:117461952ENST00000455858711297_336389533.0RepeatNote=WD 3


Top

Fusion Gene Sequence for ULK1-FBXW8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96750_96750_1_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461951_ENST00000309909_length(transcript)=3929nt_BP=3035nt
GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG
GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA
CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC
CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC
GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC
CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA
ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTGGTTATGGAG
TACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAGCAGATCGCG
GGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCCGGCCGCCGC
GCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACACTCTGCGGC
TCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATCGTCTACCAG
TGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTCCCCACCATC
CCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGATGAGTTTTTT
CATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCCGGCAGCAGC
TCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCCCCGGCTGAC
ACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTCCCCGCGCAG
TTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTGGCCTCTGCG
GGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCGTTCTCCAGC
AGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCACCCACCCAG
TTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCCCCTGCCCAC
GCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACCATCCCTGAG
CGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGGCTCCTCTGCACCCGAGCAC
TCTCCCCGCACTTCCGGGCTGGGCTGCCGCCTGCACAGCGCCCCCAACCTGTCTGACTTGCACGTCGTCCGCCCCAAGCTGCCCAAACCC
CCCACGGACCCCCTGGGAGCTGTGTTCAGCCCACCACAGGCCAGCCCTCCCCAGCCGTCCCACGGCCTGCAGTCCTGCCGGAACCTGCGG
GGCTCACCCAAGCTGCCCGACTTCCTGCAGCGAAACCCCCTGCCCCCCATCCTGGGCTCCCCCACCAAGGCTGTGCCCTCCTTTGACTTC
CCGAAGACCCCCAGCTCCCAGAACCTGCTGGCCCTCCTAGCCCGGCAGGGCGTGGTGATGACGCCCCCTCGAAACCGGACGCTGCCCGAC
CTCTCGGAGGTGGGACCCTTCCATGGTCAGCCGTTGGGCCCTGGCCTGCGGCCAGGCGAGGACCCCAAGGGCCCCTTTGGCCGGTCTTTC
AGCACCAGCCGCCTCACTGACCTGCTCCTTAAGGCGGCGTTTGGGACACAAGCCCCGGACCCGGGCAGCACGGAGAGCCTGCAGGAGAAG
CCCATGGAGATCGCACCCTCAGCTGGCTTTGGAGGGAGCCTGCACCCAGGAGCCCGTGCTGGGGGCACCAGCAGCCCTTCCCCGGTGGTC
TTCACCGTGGGCTCTCCCCCGAGCGGGAGCACGCCCCCCCAGGGCCCCCGCACCAGGATGTTCTCAGCGGGCCCCACTGGCTCTGCCAGC
TCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTGAGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGAC
CCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCCCTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATC
CTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCGCAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGC
CCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGAGCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGT
GGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAA
GGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGC
CACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGG
CTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACT
CACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTGCCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAG
TTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAGGGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCAC
GCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGTGCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACAT
AGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGCCTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGC
TTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCTTTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGG

>96750_96750_1_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461951_ENST00000309909_length(amino acids)=1096AA_BP=946
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSP
VVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHT
EILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGG
EEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM

--------------------------------------------------------------
>96750_96750_2_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461951_ENST00000455858_length(transcript)=6441nt_BP=3035nt
GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG
GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA
CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC
CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC
GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC
CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA
ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTGGTTATGGAG
TACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAGCAGATCGCG
GGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCCGGCCGCCGC
GCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACACTCTGCGGC
TCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATCGTCTACCAG
TGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTCCCCACCATC
CCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGATGAGTTTTTT
CATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCCGGCAGCAGC
TCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCCCCGGCTGAC
ACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTCCCCGCGCAG
TTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTGGCCTCTGCG
GGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCGTTCTCCAGC
AGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCACCCACCCAG
TTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCCCCTGCCCAC
GCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACCATCCCTGAG
CGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGGCTCCTCTGCACCCGAGCAC
TCTCCCCGCACTTCCGGGCTGGGCTGCCGCCTGCACAGCGCCCCCAACCTGTCTGACTTGCACGTCGTCCGCCCCAAGCTGCCCAAACCC
CCCACGGACCCCCTGGGAGCTGTGTTCAGCCCACCACAGGCCAGCCCTCCCCAGCCGTCCCACGGCCTGCAGTCCTGCCGGAACCTGCGG
GGCTCACCCAAGCTGCCCGACTTCCTGCAGCGAAACCCCCTGCCCCCCATCCTGGGCTCCCCCACCAAGGCTGTGCCCTCCTTTGACTTC
CCGAAGACCCCCAGCTCCCAGAACCTGCTGGCCCTCCTAGCCCGGCAGGGCGTGGTGATGACGCCCCCTCGAAACCGGACGCTGCCCGAC
CTCTCGGAGGTGGGACCCTTCCATGGTCAGCCGTTGGGCCCTGGCCTGCGGCCAGGCGAGGACCCCAAGGGCCCCTTTGGCCGGTCTTTC
AGCACCAGCCGCCTCACTGACCTGCTCCTTAAGGCGGCGTTTGGGACACAAGCCCCGGACCCGGGCAGCACGGAGAGCCTGCAGGAGAAG
CCCATGGAGATCGCACCCTCAGCTGGCTTTGGAGGGAGCCTGCACCCAGGAGCCCGTGCTGGGGGCACCAGCAGCCCTTCCCCGGTGGTC
TTCACCGTGGGCTCTCCCCCGAGCGGGAGCACGCCCCCCCAGGGCCCCCGCACCAGGATGTTCTCAGCGGGCCCCACTGGCTCTGCCAGC
TCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTGAGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGAC
CCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCCCTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATC
CTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCGCAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGC
CCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGAGCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGT
GGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAA
GGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGC
CACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGG
CTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACT
CACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTGCCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAG
TTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAGGGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCAC
GCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGTGCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACAT
AGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGCCTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGC
TTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCTTTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGG
CCTTTGGATGTGCTTGTTCCTGGCCTCCAAGGCAATAACCTCCATGTCCTTTTCCCTGTATTTACTTGGGGTGCTCTTCTGTGACACTTG
CCACCACCACCTTCCAGTAGCAAGCTGGTAGAGCTGTACTTTTTCTTCACAGCTTTTACCATGGTTTATAATTATATACTTATACAGTTT
AGTCATCAATGACTATTTTGCTTACTATTGTGTCTATGATATGTGATACAAAGCAAATATTTTCTAAATATTCATTGACTAAACAGCCAT
CAAGATGAAACAGGACAGGAGAGAACTGTTCAGTGTGATACAGAGCTGCCATTTCCAAAGTATTCTGGAAGCAAGCCATTGCCTTACTCT
TGATTTTCAACAGTTCTAAACAGCAACAGCATCCACCTAATATACCTTCAGAATATCAAAGCGAAAACTGATAGAACTACAAAGAGAAAT
AAAATCCATTCTCACGGCAGGCAAATCAGTGAGAAAAATGTAAAGATCTGGAGGATTTACTTAGTATCGCTAACAAGCTGGATCCAGTAG
ATGCGTATGGAATTTCAAATACACATAGACGATGCACAAAAAACCACCCTGTACGAAGGCCACAAAGAACAGCTCAGATGCACAAAGATT
CACACCATACAGGCCAAATTATAGAATCCCCCAACCCCAAGACACTGCACCCTATGGGCTATACCCTCAGGCAGGGCCCTGCTTTTCTAG
GAATTGACTCCAATGCAGAATAGTGAGAAATCAACAAAAAGCAAAATAAGACAATTCCAGACACTCCTGAATTTACTTGGATTTAAAGAG
GTTAATAAAAACAAACTATAAACTCTCTAGACTGGGCTGACAGTAAAAGCACAGAATACAAAACCCAGGGGATGGGGCTGGGAGGGGCTG
TGAGGGGCTGGCACCTCAGCTCAGAAAAGGTAGCAGCAATCCCAAAGCAGCAGAAGGCAGGGGTTAAATCAGGATAAAAACAGACATCAG
TGGAATCGAAAACCAATAGTTAGTTAATATAAAGCCAGAAGGTTTTGTTTTTTTTCAGGTGGGGTCTCGCTCTGTCACCTAGACTAGACT
GGAGTGCAATGGCCTGATCTCGGCTCACTGCAACCTCTGCCTCCCGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAT
TACAGGCGTCCGCTACCACAACTGGCTAATTTTTACATTTTTAGTAGAGACGGGGGATATTGCTATGTTGGCCAGGCTGGTCTCAAACTT
CTGACCTCAAATGATTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGTCACTGTACCCAGCCCAAAAGCAGTTTAAAAA
AAAAAAAGACAAAATATACAACTCTTGATAAAACATAAAGGTACAGTGGTCTATGAGGAAGAGAAAAGGTACCTGAGGATGCAGAAGTAC
CTACCACATGGGAACCGTTTGTCCACACTCATTCCAGAGAAAACCGAGTCCTCTCAGTTGCACACGTGTACGTATCAGTGGGAAGTGCTT
GCCATTACTCCAAAGCCTAGAACCTTCACGTCATGAAGGTTCTGGAAGGTTTTTCAGATTGCTTAAGATACGCAGCCATTCCATATTCAT
CTCCAACTACACAGGGGAACGGAGCAGATAGAGCTGCGACTGGGAAGCGTCACCTTCCCGTCCAGAGCGCTTTCTTTCAGACCCTGCCTA
CCTGCAGGCAGATGGACCGGAGGGTTTTCTGCTTCCTTTCAACCAGATAACTTCCTAAGTGGAGATGGCCTGTAGGTAGCAAATGCAGGA
TTTTGTTTACTTTCATCATGTCATGTGGTGGTCAGACTGCTCGCTGGTGGCCTCGCTTTAGAAGGTTTTCATCAAGCCCCGCCCTTTCTC
TCTCATAGTCTTAATGCGTCTGGACCACTGGGGAAAATATTTTTCTTTTCAAAAAGCAGCCCCTTCAGTCTGCGTTCCCAGTTCATTTTG
CAGGCGCATTCGCCCTTCCTAGTTTGCAGCAATTAAAGATAACGGAGTGTAAAGTCATTAGACCCAGAATTAGAGCAGCCAGCAGCTGGC
CCAGTGTAAAAATGTCCCAAGTGTAGCCCCTCCCACCGCAGAGCCTGTTTCTAACGTACCTGCCATTCGTGGAAGTCGCCTGGGTTTTGT
AAAGGAGAATTTTTTGGACTCAAGCTGTCATCTTCAAGCACGCCAACTTCAGGCAGTGTTTTCTACTGCAAACCTCCACATCCTGGAATC
AATCACACTGACAGGGAAAGGATAAATGCTCCTTTATAAGCCAACATGTATCCAAATTAAGCCCCCTTACCTTTATCCAGACCCTTTCAC
AAACAAGTTCTGAGTTTTTAGCCAATTGATCCTCTACTTTCCTTCTTTAGTCCCTCTCAGGGACGCCTCCATCCCCGGCTCCCCTAAAGG
TAGAAGATACTCGAGCATGCTGCCAGGGGAGCTGGATGGTGAAACACCTGAAGATCTCATATCGCCTCTCAAAACACTGTCGGACTTGCT

>96750_96750_2_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461951_ENST00000455858_length(amino acids)=1096AA_BP=946
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSP
VVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHT
EILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGG
EEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM

--------------------------------------------------------------
>96750_96750_3_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461952_ENST00000309909_length(transcript)=3929nt_BP=3035nt
GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG
GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA
CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC
CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC
GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC
CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA
ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTGGTTATGGAG
TACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAGCAGATCGCG
GGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCCGGCCGCCGC
GCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACACTCTGCGGC
TCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATCGTCTACCAG
TGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTCCCCACCATC
CCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGATGAGTTTTTT
CATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCCGGCAGCAGC
TCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCCCCGGCTGAC
ACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTCCCCGCGCAG
TTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTGGCCTCTGCG
GGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCGTTCTCCAGC
AGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCACCCACCCAG
TTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCCCCTGCCCAC
GCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACCATCCCTGAG
CGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGGCTCCTCTGCACCCGAGCAC
TCTCCCCGCACTTCCGGGCTGGGCTGCCGCCTGCACAGCGCCCCCAACCTGTCTGACTTGCACGTCGTCCGCCCCAAGCTGCCCAAACCC
CCCACGGACCCCCTGGGAGCTGTGTTCAGCCCACCACAGGCCAGCCCTCCCCAGCCGTCCCACGGCCTGCAGTCCTGCCGGAACCTGCGG
GGCTCACCCAAGCTGCCCGACTTCCTGCAGCGAAACCCCCTGCCCCCCATCCTGGGCTCCCCCACCAAGGCTGTGCCCTCCTTTGACTTC
CCGAAGACCCCCAGCTCCCAGAACCTGCTGGCCCTCCTAGCCCGGCAGGGCGTGGTGATGACGCCCCCTCGAAACCGGACGCTGCCCGAC
CTCTCGGAGGTGGGACCCTTCCATGGTCAGCCGTTGGGCCCTGGCCTGCGGCCAGGCGAGGACCCCAAGGGCCCCTTTGGCCGGTCTTTC
AGCACCAGCCGCCTCACTGACCTGCTCCTTAAGGCGGCGTTTGGGACACAAGCCCCGGACCCGGGCAGCACGGAGAGCCTGCAGGAGAAG
CCCATGGAGATCGCACCCTCAGCTGGCTTTGGAGGGAGCCTGCACCCAGGAGCCCGTGCTGGGGGCACCAGCAGCCCTTCCCCGGTGGTC
TTCACCGTGGGCTCTCCCCCGAGCGGGAGCACGCCCCCCCAGGGCCCCCGCACCAGGATGTTCTCAGCGGGCCCCACTGGCTCTGCCAGC
TCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTGAGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGAC
CCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCCCTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATC
CTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCGCAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGC
CCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGAGCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGT
GGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAA
GGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGC
CACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGG
CTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACT
CACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTGCCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAG
TTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAGGGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCAC
GCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGTGCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACAT
AGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGCCTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGC
TTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCTTTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGG

>96750_96750_3_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461952_ENST00000309909_length(amino acids)=1096AA_BP=946
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSP
VVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHT
EILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGG
EEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM

--------------------------------------------------------------
>96750_96750_4_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461952_ENST00000455858_length(transcript)=6441nt_BP=3035nt
GAGGCCCGGGCGCCGCGGCTCTTTTGTTTCTCCGTTGGGGCCGAGCCCGGGCCCTAGTTGGAGCCGGAGTCGGAGTCGGAGTCGGATCCG
GATTCGGATTAGCAGCCCGGGAAGAGTGCCGTGGCACAGGCGCCGGAGGGAGCGCGACCCTCGGACCCCGCCTGGCCCGCGGGGCTGGGA
CCCGGCCCCGGCCTGCCCGATGGGGCGCGCGGCCCCGGAGATGCGCCCTCGCCCGGCCCCGCGCCCCCGGCCCCGCGCCCCCGGCCCGCC
CGCCCCGGCCCGCGCCTCCGCCTGAGTCCCCCGCGCCTTGGCCCGCCACCCCCCGCCCCGCGCCCCCGGCCCGCCTGCGCCATGGAGCCC
GGCCGCGGCGGCACAGAGACCGTGGGCAAGTTCGAGTTCTCCCGCAAGGACCTGATCGGCCACGGCGCCTTCGCGGTGGTCTTCAAGGGC
CGCCACCGCGAGAAGCACGATTTGGAGGTCGCCGTCAAGTGCATTAACAAGAAGAACCTCGCCAAGTCTCAGACGCTGCTGGGGAAGGAA
ATCAAAATCCTGAAGGAACTGAAACATGAAAACATCGTGGCCCTGTACGACTTCCAGGAAATGGCTAATTCTGTCTACCTGGTTATGGAG
TACTGCAACGGTGGGGACCTGGCCGACTACCTGCACGCCATGCGCACGCTGAGCGAGGACACCATCAGGCTCTTCCTGCAGCAGATCGCG
GGCGCCATGCGGCTTCTGCACAGCAAAGGCATCATCCACCGCGACCTGAAACCGCAGAACATCCTGCTGTCCAACCCCGCCGGCCGCCGC
GCCAACCCCAACAGCATCCGCGTCAAGATCGCTGACTTCGGCTTCGCGCGGTACCTCCAGAGCAACATGATGGCGGCCACACTCTGCGGC
TCCCCCATGTACATGGCCCCCGAGGTCATCATGTCCCAGCACTACGACGGGAAGGCGGACCTGTGGAGCATCGGCACCATCGTCTACCAG
TGCCTGACGGGGAAGGCGCCCTTCCAGGCCAGCAGCCCCCAGGACCTGCGCCTGTTCTACGAGAAGAACAAGACGTTGGTCCCCACCATC
CCCCGGGAGACCTCGGCCCCGCTGCGGCAGCTGCTCCTGGCCCTACTGCAACGCAACCACAAGGACCGCATGGACTTCGATGAGTTTTTT
CATCACCCTTTCCTCGATGCCAGCCCCTCGGTCAGGAAATCCCCACCCGTGCCTGTGCCCTCGTACCCAAGCTCGGGGTCCGGCAGCAGC
TCCAGCAGCAGCTCCACCTCCCACCTGGCCTCCCCGCCGTCCCTGGGCGAGATGCAGCAGCTGCAGAAGACCCTGGCCTCCCCGGCTGAC
ACCGCTGGCTTCCTGCACAGCTCCCGGGACTCTGGTGGCAGCAAGGACTCTTCCTGTGACACAGACGACTTCGTCATGGTCCCCGCGCAG
TTTCCAGGTGACCTGGTGGCTGAGGCGCCCAGTGCCAAACCCCCGCCAGACAGCCTGATGTGCAGTGGGAGCTCACTGGTGGCCTCTGCG
GGCTTGGAGAGCCACGGCCGGACCCCATCTCCATCCCCACCCTGCAGCAGCTCCCCCAGTCCCTCAGGCCGGGCTGGCCCGTTCTCCAGC
AGCAGGTGCGGCGCCTCTGTCCCCATCCCAGTCCCCACGCAGGTGCAGAACTACCAGCGCATTGAGCGAAACCTGCAGTCACCCACCCAG
TTCCAAACACCTCGGTCCTCTGCCATCCGCAGGTCAGGCAGCACCAGCCCCCTGGGCTTTGCAAGGGCCAGCCCCTCGCCCCCTGCCCAC
GCTGAGCATGGAGGCGTCCTGGCCAGGAAGATGTCTCTGGGTGGAGGCCGGCCCTACACGCCATCTCCTCAAGTTGGAACCATCCCTGAG
CGGCCAGGCTGGAGCGGGACGCCCTCCCCACAGGGAGCTGAGATGCGGGGTGGCAGGTCCCCTCGTCCAGGCTCCTCTGCACCCGAGCAC
TCTCCCCGCACTTCCGGGCTGGGCTGCCGCCTGCACAGCGCCCCCAACCTGTCTGACTTGCACGTCGTCCGCCCCAAGCTGCCCAAACCC
CCCACGGACCCCCTGGGAGCTGTGTTCAGCCCACCACAGGCCAGCCCTCCCCAGCCGTCCCACGGCCTGCAGTCCTGCCGGAACCTGCGG
GGCTCACCCAAGCTGCCCGACTTCCTGCAGCGAAACCCCCTGCCCCCCATCCTGGGCTCCCCCACCAAGGCTGTGCCCTCCTTTGACTTC
CCGAAGACCCCCAGCTCCCAGAACCTGCTGGCCCTCCTAGCCCGGCAGGGCGTGGTGATGACGCCCCCTCGAAACCGGACGCTGCCCGAC
CTCTCGGAGGTGGGACCCTTCCATGGTCAGCCGTTGGGCCCTGGCCTGCGGCCAGGCGAGGACCCCAAGGGCCCCTTTGGCCGGTCTTTC
AGCACCAGCCGCCTCACTGACCTGCTCCTTAAGGCGGCGTTTGGGACACAAGCCCCGGACCCGGGCAGCACGGAGAGCCTGCAGGAGAAG
CCCATGGAGATCGCACCCTCAGCTGGCTTTGGAGGGAGCCTGCACCCAGGAGCCCGTGCTGGGGGCACCAGCAGCCCTTCCCCGGTGGTC
TTCACCGTGGGCTCTCCCCCGAGCGGGAGCACGCCCCCCCAGGGCCCCCGCACCAGGATGTTCTCAGCGGGCCCCACTGGCTCTGCCAGC
TCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTGAGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGAC
CCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCCCTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATC
CTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCGCAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGC
CCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGAGCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGT
GGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGCAGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAA
GGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGTATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGC
CACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCGACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGG
CTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTCTCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACT
CACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTGCCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAG
TTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAGGGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCAC
GCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGTGCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACAT
AGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGCCTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGC
TTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCTTTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGG
CCTTTGGATGTGCTTGTTCCTGGCCTCCAAGGCAATAACCTCCATGTCCTTTTCCCTGTATTTACTTGGGGTGCTCTTCTGTGACACTTG
CCACCACCACCTTCCAGTAGCAAGCTGGTAGAGCTGTACTTTTTCTTCACAGCTTTTACCATGGTTTATAATTATATACTTATACAGTTT
AGTCATCAATGACTATTTTGCTTACTATTGTGTCTATGATATGTGATACAAAGCAAATATTTTCTAAATATTCATTGACTAAACAGCCAT
CAAGATGAAACAGGACAGGAGAGAACTGTTCAGTGTGATACAGAGCTGCCATTTCCAAAGTATTCTGGAAGCAAGCCATTGCCTTACTCT
TGATTTTCAACAGTTCTAAACAGCAACAGCATCCACCTAATATACCTTCAGAATATCAAAGCGAAAACTGATAGAACTACAAAGAGAAAT
AAAATCCATTCTCACGGCAGGCAAATCAGTGAGAAAAATGTAAAGATCTGGAGGATTTACTTAGTATCGCTAACAAGCTGGATCCAGTAG
ATGCGTATGGAATTTCAAATACACATAGACGATGCACAAAAAACCACCCTGTACGAAGGCCACAAAGAACAGCTCAGATGCACAAAGATT
CACACCATACAGGCCAAATTATAGAATCCCCCAACCCCAAGACACTGCACCCTATGGGCTATACCCTCAGGCAGGGCCCTGCTTTTCTAG
GAATTGACTCCAATGCAGAATAGTGAGAAATCAACAAAAAGCAAAATAAGACAATTCCAGACACTCCTGAATTTACTTGGATTTAAAGAG
GTTAATAAAAACAAACTATAAACTCTCTAGACTGGGCTGACAGTAAAAGCACAGAATACAAAACCCAGGGGATGGGGCTGGGAGGGGCTG
TGAGGGGCTGGCACCTCAGCTCAGAAAAGGTAGCAGCAATCCCAAAGCAGCAGAAGGCAGGGGTTAAATCAGGATAAAAACAGACATCAG
TGGAATCGAAAACCAATAGTTAGTTAATATAAAGCCAGAAGGTTTTGTTTTTTTTCAGGTGGGGTCTCGCTCTGTCACCTAGACTAGACT
GGAGTGCAATGGCCTGATCTCGGCTCACTGCAACCTCTGCCTCCCGAGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAT
TACAGGCGTCCGCTACCACAACTGGCTAATTTTTACATTTTTAGTAGAGACGGGGGATATTGCTATGTTGGCCAGGCTGGTCTCAAACTT
CTGACCTCAAATGATTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTAAGTCACTGTACCCAGCCCAAAAGCAGTTTAAAAA
AAAAAAAGACAAAATATACAACTCTTGATAAAACATAAAGGTACAGTGGTCTATGAGGAAGAGAAAAGGTACCTGAGGATGCAGAAGTAC
CTACCACATGGGAACCGTTTGTCCACACTCATTCCAGAGAAAACCGAGTCCTCTCAGTTGCACACGTGTACGTATCAGTGGGAAGTGCTT
GCCATTACTCCAAAGCCTAGAACCTTCACGTCATGAAGGTTCTGGAAGGTTTTTCAGATTGCTTAAGATACGCAGCCATTCCATATTCAT
CTCCAACTACACAGGGGAACGGAGCAGATAGAGCTGCGACTGGGAAGCGTCACCTTCCCGTCCAGAGCGCTTTCTTTCAGACCCTGCCTA
CCTGCAGGCAGATGGACCGGAGGGTTTTCTGCTTCCTTTCAACCAGATAACTTCCTAAGTGGAGATGGCCTGTAGGTAGCAAATGCAGGA
TTTTGTTTACTTTCATCATGTCATGTGGTGGTCAGACTGCTCGCTGGTGGCCTCGCTTTAGAAGGTTTTCATCAAGCCCCGCCCTTTCTC
TCTCATAGTCTTAATGCGTCTGGACCACTGGGGAAAATATTTTTCTTTTCAAAAAGCAGCCCCTTCAGTCTGCGTTCCCAGTTCATTTTG
CAGGCGCATTCGCCCTTCCTAGTTTGCAGCAATTAAAGATAACGGAGTGTAAAGTCATTAGACCCAGAATTAGAGCAGCCAGCAGCTGGC
CCAGTGTAAAAATGTCCCAAGTGTAGCCCCTCCCACCGCAGAGCCTGTTTCTAACGTACCTGCCATTCGTGGAAGTCGCCTGGGTTTTGT
AAAGGAGAATTTTTTGGACTCAAGCTGTCATCTTCAAGCACGCCAACTTCAGGCAGTGTTTTCTACTGCAAACCTCCACATCCTGGAATC
AATCACACTGACAGGGAAAGGATAAATGCTCCTTTATAAGCCAACATGTATCCAAATTAAGCCCCCTTACCTTTATCCAGACCCTTTCAC
AAACAAGTTCTGAGTTTTTAGCCAATTGATCCTCTACTTTCCTTCTTTAGTCCCTCTCAGGGACGCCTCCATCCCCGGCTCCCCTAAAGG
TAGAAGATACTCGAGCATGCTGCCAGGGGAGCTGGATGGTGAAACACCTGAAGATCTCATATCGCCTCTCAAAACACTGTCGGACTTGCT

>96750_96750_4_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000321867_FBXW8_chr12_117461952_ENST00000455858_length(amino acids)=1096AA_BP=946
MGPGPGLPDGARGPGDAPSPGPAPPAPRPRPARPGPRLRLSPPRLGPPPPAPRPRPACAMEPGRGGTETVGKFEFSRKDLIGHGAFAVVF
KGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQ
IAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSG
SSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVA
SAGLESHGRTPSPSPPCSSSPSPSGRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSPP
AHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLP
KPPTDPLGAVFSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRTL
PDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSP
VVFTVGSPPSGSTPPQGPRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEHT
EILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSAHQLRVSAVQMDDWKIVSGG
EEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAVDQLAFQSPLPVCRSSCDAM

--------------------------------------------------------------
>96750_96750_5_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461951_ENST00000309909_length(transcript)=1447nt_BP=553nt
TGTGGTGAGTGGCAAGAGGTTGAGGAGTGGCTCTAGGGGCCTGCTGTGCTTCTCCTGTTGGAGCATTGGGATATAACAGGTGTAAACCGA
GGCAGAGGCACATTGGGCCCTGGAGGTGTGGGAGTCTGTGGGGGATGGATGGGGGCCACGGTGTCTGCTGGTCCTGGTGTGCCCCTCATC
GCCCTCTCCCTGCAGCGGGCCCCACTGGCTCTGCCAGCTCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTG
AGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGACCCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCC
CTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATCCTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCG
CAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGCCCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGA
GCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGTGGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGC
AGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAAGGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGT
ATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGCCACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCG
ACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGGCTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTC
TCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACTCACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTG
CCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAGTTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAG
GGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCACGCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGT
GCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACATAGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGC
CTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGCTTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCT
TTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGGCCTTTGGATGTGCTTGTTCCTGGCCTCCAAGGCAATAACCTCCATGTCCTTT

>96750_96750_5_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461951_ENST00000309909_length(amino acids)=305AA_BP=155
MGYNRCKPRQRHIGPWRCGSLWGMDGGHGVCWSWCAPHRPLPAAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGA
VTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSA
HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAV

--------------------------------------------------------------
>96750_96750_6_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461951_ENST00000455858_length(transcript)=3959nt_BP=553nt
TGTGGTGAGTGGCAAGAGGTTGAGGAGTGGCTCTAGGGGCCTGCTGTGCTTCTCCTGTTGGAGCATTGGGATATAACAGGTGTAAACCGA
GGCAGAGGCACATTGGGCCCTGGAGGTGTGGGAGTCTGTGGGGGATGGATGGGGGCCACGGTGTCTGCTGGTCCTGGTGTGCCCCTCATC
GCCCTCTCCCTGCAGCGGGCCCCACTGGCTCTGCCAGCTCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTG
AGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGACCCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCC
CTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATCCTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCG
CAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGCCCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGA
GCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGTGGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGC
AGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAAGGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGT
ATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGCCACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCG
ACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGGCTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTC
TCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACTCACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTG
CCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAGTTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAG
GGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCACGCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGT
GCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACATAGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGC
CTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGCTTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCT
TTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGGCCTTTGGATGTGCTTGTTCCTGGCCTCCAAGGCAATAACCTCCATGTCCTTT
TCCCTGTATTTACTTGGGGTGCTCTTCTGTGACACTTGCCACCACCACCTTCCAGTAGCAAGCTGGTAGAGCTGTACTTTTTCTTCACAG
CTTTTACCATGGTTTATAATTATATACTTATACAGTTTAGTCATCAATGACTATTTTGCTTACTATTGTGTCTATGATATGTGATACAAA
GCAAATATTTTCTAAATATTCATTGACTAAACAGCCATCAAGATGAAACAGGACAGGAGAGAACTGTTCAGTGTGATACAGAGCTGCCAT
TTCCAAAGTATTCTGGAAGCAAGCCATTGCCTTACTCTTGATTTTCAACAGTTCTAAACAGCAACAGCATCCACCTAATATACCTTCAGA
ATATCAAAGCGAAAACTGATAGAACTACAAAGAGAAATAAAATCCATTCTCACGGCAGGCAAATCAGTGAGAAAAATGTAAAGATCTGGA
GGATTTACTTAGTATCGCTAACAAGCTGGATCCAGTAGATGCGTATGGAATTTCAAATACACATAGACGATGCACAAAAAACCACCCTGT
ACGAAGGCCACAAAGAACAGCTCAGATGCACAAAGATTCACACCATACAGGCCAAATTATAGAATCCCCCAACCCCAAGACACTGCACCC
TATGGGCTATACCCTCAGGCAGGGCCCTGCTTTTCTAGGAATTGACTCCAATGCAGAATAGTGAGAAATCAACAAAAAGCAAAATAAGAC
AATTCCAGACACTCCTGAATTTACTTGGATTTAAAGAGGTTAATAAAAACAAACTATAAACTCTCTAGACTGGGCTGACAGTAAAAGCAC
AGAATACAAAACCCAGGGGATGGGGCTGGGAGGGGCTGTGAGGGGCTGGCACCTCAGCTCAGAAAAGGTAGCAGCAATCCCAAAGCAGCA
GAAGGCAGGGGTTAAATCAGGATAAAAACAGACATCAGTGGAATCGAAAACCAATAGTTAGTTAATATAAAGCCAGAAGGTTTTGTTTTT
TTTCAGGTGGGGTCTCGCTCTGTCACCTAGACTAGACTGGAGTGCAATGGCCTGATCTCGGCTCACTGCAACCTCTGCCTCCCGAGTTCA
AGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTCCGCTACCACAACTGGCTAATTTTTACATTTTTAGTAGAGACG
GGGGATATTGCTATGTTGGCCAGGCTGGTCTCAAACTTCTGACCTCAAATGATTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGG
TGTAAGTCACTGTACCCAGCCCAAAAGCAGTTTAAAAAAAAAAAAGACAAAATATACAACTCTTGATAAAACATAAAGGTACAGTGGTCT
ATGAGGAAGAGAAAAGGTACCTGAGGATGCAGAAGTACCTACCACATGGGAACCGTTTGTCCACACTCATTCCAGAGAAAACCGAGTCCT
CTCAGTTGCACACGTGTACGTATCAGTGGGAAGTGCTTGCCATTACTCCAAAGCCTAGAACCTTCACGTCATGAAGGTTCTGGAAGGTTT
TTCAGATTGCTTAAGATACGCAGCCATTCCATATTCATCTCCAACTACACAGGGGAACGGAGCAGATAGAGCTGCGACTGGGAAGCGTCA
CCTTCCCGTCCAGAGCGCTTTCTTTCAGACCCTGCCTACCTGCAGGCAGATGGACCGGAGGGTTTTCTGCTTCCTTTCAACCAGATAACT
TCCTAAGTGGAGATGGCCTGTAGGTAGCAAATGCAGGATTTTGTTTACTTTCATCATGTCATGTGGTGGTCAGACTGCTCGCTGGTGGCC
TCGCTTTAGAAGGTTTTCATCAAGCCCCGCCCTTTCTCTCTCATAGTCTTAATGCGTCTGGACCACTGGGGAAAATATTTTTCTTTTCAA
AAAGCAGCCCCTTCAGTCTGCGTTCCCAGTTCATTTTGCAGGCGCATTCGCCCTTCCTAGTTTGCAGCAATTAAAGATAACGGAGTGTAA
AGTCATTAGACCCAGAATTAGAGCAGCCAGCAGCTGGCCCAGTGTAAAAATGTCCCAAGTGTAGCCCCTCCCACCGCAGAGCCTGTTTCT
AACGTACCTGCCATTCGTGGAAGTCGCCTGGGTTTTGTAAAGGAGAATTTTTTGGACTCAAGCTGTCATCTTCAAGCACGCCAACTTCAG
GCAGTGTTTTCTACTGCAAACCTCCACATCCTGGAATCAATCACACTGACAGGGAAAGGATAAATGCTCCTTTATAAGCCAACATGTATC
CAAATTAAGCCCCCTTACCTTTATCCAGACCCTTTCACAAACAAGTTCTGAGTTTTTAGCCAATTGATCCTCTACTTTCCTTCTTTAGTC
CCTCTCAGGGACGCCTCCATCCCCGGCTCCCCTAAAGGTAGAAGATACTCGAGCATGCTGCCAGGGGAGCTGGATGGTGAAACACCTGAA

>96750_96750_6_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461951_ENST00000455858_length(amino acids)=305AA_BP=155
MGYNRCKPRQRHIGPWRCGSLWGMDGGHGVCWSWCAPHRPLPAAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGA
VTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSA
HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAV

--------------------------------------------------------------
>96750_96750_7_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461952_ENST00000309909_length(transcript)=1447nt_BP=553nt
TGTGGTGAGTGGCAAGAGGTTGAGGAGTGGCTCTAGGGGCCTGCTGTGCTTCTCCTGTTGGAGCATTGGGATATAACAGGTGTAAACCGA
GGCAGAGGCACATTGGGCCCTGGAGGTGTGGGAGTCTGTGGGGGATGGATGGGGGCCACGGTGTCTGCTGGTCCTGGTGTGCCCCTCATC
GCCCTCTCCCTGCAGCGGGCCCCACTGGCTCTGCCAGCTCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTG
AGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGACCCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCC
CTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATCCTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCG
CAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGCCCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGA
GCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGTGGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGC
AGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAAGGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGT
ATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGCCACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCG
ACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGGCTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTC
TCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACTCACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTG
CCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAGTTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAG
GGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCACGCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGT
GCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACATAGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGC
CTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGCTTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCT
TTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGGCCTTTGGATGTGCTTGTTCCTGGCCTCCAAGGCAATAACCTCCATGTCCTTT

>96750_96750_7_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461952_ENST00000309909_length(amino acids)=305AA_BP=155
MGYNRCKPRQRHIGPWRCGSLWGMDGGHGVCWSWCAPHRPLPAAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGA
VTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSA
HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAV

--------------------------------------------------------------
>96750_96750_8_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461952_ENST00000455858_length(transcript)=3959nt_BP=553nt
TGTGGTGAGTGGCAAGAGGTTGAGGAGTGGCTCTAGGGGCCTGCTGTGCTTCTCCTGTTGGAGCATTGGGATATAACAGGTGTAAACCGA
GGCAGAGGCACATTGGGCCCTGGAGGTGTGGGAGTCTGTGGGGGATGGATGGGGGCCACGGTGTCTGCTGGTCCTGGTGTGCCCCTCATC
GCCCTCTCCCTGCAGCGGGCCCCACTGGCTCTGCCAGCTCTTCTGCCCGCCACCTGGTGCCTGGGCCCTGCAGCGAGGCCCCAGCCCCTG
AGCTCCCTGCTCCAGGACACGGCTGCAGCTTTGCCGACCCCATTACTGCGAACCTGGAGGGGGCTGTGACCTTCGAGGCCCCCGACCTCC
CTGAGGAGACCCTCATGGAGCAAGAGCACACGGAGATCCTGCGTGGCCTGCGCTTCACGCTGCTGTTCGTGCAGCACGTCCTGGAGATCG
CAGCCCTGAAGGGCAGCGCCAGTGAGGCGGCGGGGGGCCCTGAGTACCAGCTGCAGGAGAGTGTGGTGGCCGACCAGATCAGCCTGCTGA
GCCGAGAATGGGGGGTGAGGATCCACGACCTCCGCAGTGGTAACATCGCCCTGTCGCTCTCCGCCCATCAGCTCAGGGTCTCTGCTGTGC
AGATGGATGACTGGAAGATCGTCAGTGGAGGCGAGGAAGGCCTGGTGTCCGTGTGGGATTATCGGATGAACCAGAAGCTGTGGGAGGTGT
ATTCCGGGCACCCGGTGCAGCACATCTCATTCAGCAGCCACAGCCTCATCACGGCCAACGTGCCTTACCAGACGGTAATGCGAAACGCCG
ACCTGGACAGCTTCACTACTCACAGGAGACACCGGGGGCTGATCCGCGCCTATGAGTTTGCGGTGGACCAGCTGGCCTTCCAGAGCCCTC
TCCCTGTCTGCCGTTCATCCTGTGACGCCATGGCCACTCACTACTACGACCTCGCACTGGCCTTTCCCTATAACCATGTTTAGGGATGTG
CCTCAGTTGGGAGCAAGGAGAAAAATGGGAAGAACCAGTTTTATCCATCTTAAAACGCCAGGCACCTCTTCACAGGTGGTAAACATTTAG
GGGAAGAAAGCAGCCCAGGGTGCCATGCCTGACAGCACGCATCTCCCTGACCCCTGCACTTCCCCCAGCGCCTGGGGCAAGCTGGCGTGT
GCCAGGGCTCGAGTCCCACGTGCTGCCAACTCAAACATAGCCTCCTTCCCCACCCAGCTGGCCACCCTGGCCTCAGCTCCCTCAGGACGC
CTCAGGGATCTCGCTGCGCGGTCCTATACGGTCCCTGCTTAGCCAGCTTCTGTGTGTCCGCCCTCCCAGCTCCAGCCCTGCAGGCCGTCT
TTTCCGTCTCCAGCCCCTTACCTCTTTTCCTCCGAGGGCCTTTGGATGTGCTTGTTCCTGGCCTCCAAGGCAATAACCTCCATGTCCTTT
TCCCTGTATTTACTTGGGGTGCTCTTCTGTGACACTTGCCACCACCACCTTCCAGTAGCAAGCTGGTAGAGCTGTACTTTTTCTTCACAG
CTTTTACCATGGTTTATAATTATATACTTATACAGTTTAGTCATCAATGACTATTTTGCTTACTATTGTGTCTATGATATGTGATACAAA
GCAAATATTTTCTAAATATTCATTGACTAAACAGCCATCAAGATGAAACAGGACAGGAGAGAACTGTTCAGTGTGATACAGAGCTGCCAT
TTCCAAAGTATTCTGGAAGCAAGCCATTGCCTTACTCTTGATTTTCAACAGTTCTAAACAGCAACAGCATCCACCTAATATACCTTCAGA
ATATCAAAGCGAAAACTGATAGAACTACAAAGAGAAATAAAATCCATTCTCACGGCAGGCAAATCAGTGAGAAAAATGTAAAGATCTGGA
GGATTTACTTAGTATCGCTAACAAGCTGGATCCAGTAGATGCGTATGGAATTTCAAATACACATAGACGATGCACAAAAAACCACCCTGT
ACGAAGGCCACAAAGAACAGCTCAGATGCACAAAGATTCACACCATACAGGCCAAATTATAGAATCCCCCAACCCCAAGACACTGCACCC
TATGGGCTATACCCTCAGGCAGGGCCCTGCTTTTCTAGGAATTGACTCCAATGCAGAATAGTGAGAAATCAACAAAAAGCAAAATAAGAC
AATTCCAGACACTCCTGAATTTACTTGGATTTAAAGAGGTTAATAAAAACAAACTATAAACTCTCTAGACTGGGCTGACAGTAAAAGCAC
AGAATACAAAACCCAGGGGATGGGGCTGGGAGGGGCTGTGAGGGGCTGGCACCTCAGCTCAGAAAAGGTAGCAGCAATCCCAAAGCAGCA
GAAGGCAGGGGTTAAATCAGGATAAAAACAGACATCAGTGGAATCGAAAACCAATAGTTAGTTAATATAAAGCCAGAAGGTTTTGTTTTT
TTTCAGGTGGGGTCTCGCTCTGTCACCTAGACTAGACTGGAGTGCAATGGCCTGATCTCGGCTCACTGCAACCTCTGCCTCCCGAGTTCA
AGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCGTCCGCTACCACAACTGGCTAATTTTTACATTTTTAGTAGAGACG
GGGGATATTGCTATGTTGGCCAGGCTGGTCTCAAACTTCTGACCTCAAATGATTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGG
TGTAAGTCACTGTACCCAGCCCAAAAGCAGTTTAAAAAAAAAAAAGACAAAATATACAACTCTTGATAAAACATAAAGGTACAGTGGTCT
ATGAGGAAGAGAAAAGGTACCTGAGGATGCAGAAGTACCTACCACATGGGAACCGTTTGTCCACACTCATTCCAGAGAAAACCGAGTCCT
CTCAGTTGCACACGTGTACGTATCAGTGGGAAGTGCTTGCCATTACTCCAAAGCCTAGAACCTTCACGTCATGAAGGTTCTGGAAGGTTT
TTCAGATTGCTTAAGATACGCAGCCATTCCATATTCATCTCCAACTACACAGGGGAACGGAGCAGATAGAGCTGCGACTGGGAAGCGTCA
CCTTCCCGTCCAGAGCGCTTTCTTTCAGACCCTGCCTACCTGCAGGCAGATGGACCGGAGGGTTTTCTGCTTCCTTTCAACCAGATAACT
TCCTAAGTGGAGATGGCCTGTAGGTAGCAAATGCAGGATTTTGTTTACTTTCATCATGTCATGTGGTGGTCAGACTGCTCGCTGGTGGCC
TCGCTTTAGAAGGTTTTCATCAAGCCCCGCCCTTTCTCTCTCATAGTCTTAATGCGTCTGGACCACTGGGGAAAATATTTTTCTTTTCAA
AAAGCAGCCCCTTCAGTCTGCGTTCCCAGTTCATTTTGCAGGCGCATTCGCCCTTCCTAGTTTGCAGCAATTAAAGATAACGGAGTGTAA
AGTCATTAGACCCAGAATTAGAGCAGCCAGCAGCTGGCCCAGTGTAAAAATGTCCCAAGTGTAGCCCCTCCCACCGCAGAGCCTGTTTCT
AACGTACCTGCCATTCGTGGAAGTCGCCTGGGTTTTGTAAAGGAGAATTTTTTGGACTCAAGCTGTCATCTTCAAGCACGCCAACTTCAG
GCAGTGTTTTCTACTGCAAACCTCCACATCCTGGAATCAATCACACTGACAGGGAAAGGATAAATGCTCCTTTATAAGCCAACATGTATC
CAAATTAAGCCCCCTTACCTTTATCCAGACCCTTTCACAAACAAGTTCTGAGTTTTTAGCCAATTGATCCTCTACTTTCCTTCTTTAGTC
CCTCTCAGGGACGCCTCCATCCCCGGCTCCCCTAAAGGTAGAAGATACTCGAGCATGCTGCCAGGGGAGCTGGATGGTGAAACACCTGAA

>96750_96750_8_ULK1-FBXW8_ULK1_chr12_132403929_ENST00000540647_FBXW8_chr12_117461952_ENST00000455858_length(amino acids)=305AA_BP=155
MGYNRCKPRQRHIGPWRCGSLWGMDGGHGVCWSWCAPHRPLPAAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGA
VTFEAPDLPEETLMEQEHTEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGVRIHDLRSGNIALSLSA
HQLRVSAVQMDDWKIVSGGEEGLVSVWDYRMNQKLWEVYSGHPVQHISFSSHSLITANVPYQTVMRNADLDSFTTHRRHRGLIRAYEFAV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ULK1-FBXW8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneULK1chr12:132403929chr12:117461951ENST00000321867+2428287_416894.66666666666661051.0GABARAP and GABARAPL2
HgeneULK1chr12:132403929chr12:117461952ENST00000321867+2428287_416894.66666666666661051.0GABARAP and GABARAPL2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ULK1-FBXW8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ULK1-FBXW8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource