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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ULK2-ACADVL (FusionGDB2 ID:96757)

Fusion Gene Summary for ULK2-ACADVL

Fusion gene summary

Fusion gene information	Fusion gene name: ULK2-ACADVL
	Fusion gene ID: 96757
		Hgene	Tgene
	Gene symbol	ULK2	ACADVL
	Gene ID	9706	37
	Gene name	unc-51 like autophagy activating kinase 2	acyl-CoA dehydrogenase very long chain
	Synonyms	ATG1B\|Unc51.2	ACAD6\|LCACD\|VLCAD
	Cytomap	17p11.2	17p13.1
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase ULK2	very long-chain specific acyl-CoA dehydrogenase, mitochondrialacyl-Coenzyme A dehydrogenase, very long chain
	Modification date	20200313	20200313
	UniProtAcc	.	P49748
	Ensembl transtripts involved in fusion gene	ENST00000361658, ENST00000395544, ENST00000580130,	ENST00000581562, ENST00000350303, ENST00000356839, ENST00000543245,
Fusion gene scores	* DoF score	7 X 7 X 4=196	11 X 12 X 7=924
	# samples	7	12
	** MAII score	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/924*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ULK2 [Title/Abstract] AND ACADVL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ULK2(19741814)-ACADVL(7123441), # samples:2
Anticipated loss of major functional domain due to fusion event.	ULK2-ACADVL seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ULK2-ACADVL seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. ULK2-ACADVL seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ULK2	GO:0006914	autophagy	18936157
Hgene	ULK2	GO:0046777	protein autophosphorylation	18936157
Tgene	ACADVL	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	7668252

Fusion gene breakpoints across ULK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACADVL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-95-A4VK-01A	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+

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Fusion Gene ORF analysis for ULK2-ACADVL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000361658	ENST00000581562	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
5CDS-3UTR	ENST00000395544	ENST00000581562	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
5UTR-3CDS	ENST00000580130	ENST00000350303	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
5UTR-3CDS	ENST00000580130	ENST00000356839	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
5UTR-3CDS	ENST00000580130	ENST00000543245	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
5UTR-3UTR	ENST00000580130	ENST00000581562	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
Frame-shift	ENST00000395544	ENST00000350303	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
Frame-shift	ENST00000395544	ENST00000356839	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
Frame-shift	ENST00000395544	ENST00000543245	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
In-frame	ENST00000361658	ENST00000350303	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
In-frame	ENST00000361658	ENST00000356839	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+
In-frame	ENST00000361658	ENST00000543245	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000361658	ULK2	chr17	19741814	-	ENST00000543245	ACADVL	chr17	7123441	+	3381	1306	1325	3211	628
ENST00000361658	ULK2	chr17	19741814	-	ENST00000356839	ACADVL	chr17	7123441	+	3388	1306	1325	3211	628
ENST00000361658	ULK2	chr17	19741814	-	ENST00000350303	ACADVL	chr17	7123441	+	3313	1306	1325	3145	606

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000361658	ENST00000543245	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+	0.00239744	0.9976025
ENST00000361658	ENST00000356839	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+	0.002417966	0.99758196
ENST00000361658	ENST00000350303	ULK2	chr17	19741814	-	ACADVL	chr17	7123441	+	0.002293447	0.99770653

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Fusion Genomic Features for ULK2-ACADVL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ULK2	chr17	19741813	-	ACADVL	chr17	7123440	+	1.63E-07	0.9999999
ULK2	chr17	19741813	-	ACADVL	chr17	7123440	+	1.63E-07	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ULK2-ACADVL

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:19741814/chr17:7123441)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACADVL P49748
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:7668252, PubMed:9461620, PubMed:18227065, PubMed:9839948, PubMed:9599005). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:7668252, PubMed:9461620, PubMed:18227065, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948). {ECO:0000269\|PubMed:18227065, ECO:0000269\|PubMed:21237683, ECO:0000269\|PubMed:7668252, ECO:0000269\|PubMed:9461620, ECO:0000269\|PubMed:9599005, ECO:0000269\|PubMed:9839948}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ULK2

chr17:19741814

chr17:7123441

ENST00000361658

15_23

262

915.3333333333334

Nucleotide binding

ATP

Hgene

ULK2

chr17:19741814

chr17:7123441

ENST00000395544

15_23

262

1037.0

Nucleotide binding

ATP

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000350303

214_223

634.0

Nucleotide binding

FAD

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000350303

249_251

634.0

Nucleotide binding

FAD

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000350303

464_466

634.0

Nucleotide binding

FAD

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000356839

214_223

656.0

Nucleotide binding

FAD

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000356839

249_251

656.0

Nucleotide binding

FAD

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000356839

464_466

656.0

Nucleotide binding

FAD

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000543245

214_223

679.0

Nucleotide binding

FAD

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000543245

249_251

679.0

Nucleotide binding

FAD

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000543245

464_466

679.0

Nucleotide binding

FAD

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000350303

41_482

634.0

Region

Catalytic

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000350303

483_516

634.0

Region

Membrane-anchoring

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000356839

41_482

656.0

Region

Catalytic

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000356839

483_516

656.0

Region

Membrane-anchoring

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000543245

41_482

679.0

Region

Catalytic

Tgene

ACADVL

chr17:19741814

chr17:7123441

ENST00000543245

483_516

679.0

Region

Membrane-anchoring

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ULK2

chr17:19741814

chr17:7123441

ENST00000361658

9_271

262

915.3333333333334

Domain

Protein kinase

Hgene

ULK2

chr17:19741814

chr17:7123441

ENST00000395544

9_271

262

1037.0

Domain

Protein kinase

Hgene

ULK2

chr17:19741814

chr17:7123441

ENST00000361658

812_1036

262

915.3333333333334

Region

Note=CTD-like region

Hgene

ULK2

chr17:19741814

chr17:7123441

ENST00000395544

812_1036

262

1037.0

Region

Note=CTD-like region

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Fusion Gene Sequence for ULK2-ACADVL

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>96757_96757_1_ULK2-ACADVL_ULK2_chr17_19741814_ENST00000361658_ACADVL_chr17_7123441_ENST00000350303_length(transcript)=3313nt_BP=1306nt
AGTCGCGCGGGAGCGGGTAGCGCGCGCGAGGGCGTTGGGCGCCGCCGCGAGGCGGGGAAGCGCGGGGCCGCGGCGGTGCGGGTTCTAGGG
CGGCGGCCGTCGCCGTCGCAGCAGCGCCCCGAGCGGGGAGGGCCGAGGAGGCCCGACGAGCTGGGGATGGAGAGTACCGGGCCCCTCACT
GCCTCAGAGCGCGTGTGCGGCTCTGGGCGCGCACAGTGACGGTGACGGCACCCCTGGCCCGGCAGCGCCGAGGCCGCTTCGCCAGACAGC
CAGCGGCCGGCGGCAGGCCGGGCCATGAGCGGCAGGGGCCGGGCCGGGCCTCGCTGACCCTGGCTCCGCGCGGCAGCTTCCCCAGTTTCC
GCTCCGGTCTCTCGGCATGAGAGTCCGCCCGGGCCCGGGGCTGCGGCTGCCCCAGACCCGCCGCACGCTGGCGCGCTCCGGGCCCGCGGA
GCCGCGGTGCTGATACCTGCGCCGCACTGCGCCGCCCGCCCGTCCGCTGTGTGCCCCGGGGGCGCGGCCATGGAGGTGGTGGGTGACTTC
GAGTACAGCAAGAGGGATCTCGTGGGACACGGGGCCTTCGCCGTGGTCTTCCGGGGGCGGCACCGCCAGAAAACTGATTGGGAGGTAGCT
ATTAAAAGTATTAATAAAAAGAACTTGTCAAAATCACAAATACTGCTTGGAAAGGAAATTAAAATCTTAAAGGAACTTCAGCATGAAAAT
ATTGTAGCACTCTATGATGTTCAGGAATTACCCAACTCTGTCTTTTTGGTGATGGAGTATTGCAATGGTGGAGACCTCGCAGATTATTTG
CAAGCGAAAGGGACTCTCAGTGAAGACACGATCAGAGTGTTTCTGCATCAGATTGCTGCTGCCATGCGAATCCTGCACAGCAAAGGAATC
ATCCACAGAGATCTCAAACCACAGAACATCTTGCTGTCCTATGCCAATCGCAGAAAATCAAGTGTCAGTGGTATTCGCATCAAAATAGCG
GATTTTGGTTTTGCTCGTTACCTACATAGTAACATGATGGCTGCAACACTGTGTGGATCCCCGATGTACATGGCTCCTGAGGTTATTATG
TCTCAACATTATGATGCTAAGGCTGACTTGTGGAGCATAGGAACAGTGATATACCAATGCCTAGTTGGAAAACCACCTTTTCAGGCCAAT
AGTCCTCAAGACTTAAGGATGTTTTATGAAAAAAACAGGAGCTTAATGCCTAGTATTCCCAGAGAAACATCACCTTATTTGGCTAATCTC
CTTTTGGGTTTGCTTCAGAGAAACCAAAAAGATAGAATGGACTTTGCTCGCGGCTCACGGCGCTCCTGGGGCAGCCCCGGCCCGGCCCTG
CCCGGCGGCCCTATGCCGGGGGTGCCGCTCAGGAATCTAAGTCCTTTGCTGTGGGAATGTTCAAAGGCCAGCTCACCACAGATCAGGTGT
TCCCATACCCGTCCGTGCTCAACGAAGAGCAGACACAGTTTCTTAAAGAGCTGGTGGAGCCTGTGTCCCGTTTCTTCGAGGAAGTGAACG
ATCCCGCCAAGAATGACGCTCTGGAGATGGTGGAGGAGACCACTTGGCAGGGCCTCAAGGAGCTGGGGGCCTTTGGTCTGCAAGTGCCCA
GTGAGCTGGGTGGTGTGGGCCTTTGCAACACCCAGTACGCCCGTTTGGTGGAGATCGTGGGCATGCATGACCTTGGCGTGGGCATTACCC
TGGGGGCCCATCAGAGCATCGGTTTCAAAGGCATCCTGCTCTTTGGCACAAAGGCCCAGAAAGAAAAATACCTCCCCAAGCTGGCATCTG
GGGAGACTGTGGCCGCTTTCTGTCTAACCGAGCCCTCAAGCGGGTCAGATGCAGCCTCCATCCGAACCTCTGCTGTGCCCAGCCCCTGTG
GAAAATACTATACCCTCAATGGAAGCAAGCTTTGGATCAGTAATGGGGGCCTAGCAGACATCTTCACGGTCTTTGCCAAGACACCAGTTA
CAGATCCAGCCACAGGAGCCGTGAAGGAGAAGATCACAGCTTTTGTGGTGGAGAGGGGCTTCGGGGGCATTACCCATGGGCCCCCTGAGA
AGAAGATGGGCATCAAGGCTTCAAACACAGCAGAGGTGTTCTTTGATGGAGTACGGGTGCCATCGGAGAACGTGCTGGGTGAGGTTGGGA
GTGGCTTCAAGGTTGCCATGCACATCCTCAACAATGGAAGGTTTGGCATGGCTGCGGCCCTGGCAGGTACCATGAGAGGCATCATTGCTA
AGGCGGTAGATCATGCCACTAATCGTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAGGAGAAGCTGGCACGGATGGTTA
TGCTGCAGTATGTAACTGAGTCCATGGCTTACATGGTGAGTGCTAACATGGACCAGGGAGCCACGGACTTCCAGATAGAGGCCGCCATCA
GCAAAATCTTTGGCTCGGAGGCAGCCTGGAAGGTGACAGATGAATGCATCCAAATCATGGGGGGTATGGGCTTCATGAAGGAACCTGGAG
TAGAGCGTGTGCTCCGAGATCTTCGCATCTTCCGGATCTTTGAGGGGACAAATGACATTCTTCGGCTGTTTGTGGCTCTGCAGGGCTGTA
TGGACAAAGGAAAGGAGCTCTCTGGGCTTGGCAGTGCTCTAAAGAATCCCTTTGGGAATGCTGGCCTCCTGCTAGGAGAGGCAGGCAAAC
AGCTGAGGCGGCGGGCAGGGCTGGGCAGCGGCCTGAGTCTCAGCGGACTTGTCCACCCGGAGTTGAGTCGGAGTGGCGAGCTGGCAGTAC
GGGCTCTGGAGCAGTTTGCCACTGTGGTGGAGGCCAAGCTGATAAAACACAAGAAGGGGATTGTCAATGAACAGTTTCTGCTGCAGCGGC
TGGCAGACGGGGCCATCGACCTCTATGCCATGGTGGTGGTTCTCTCGAGGGCCTCAAGATCCCTGAGTGAGGGCCACCCCACGGCCCAGC
ATGAGAAAATGCTCTGTGACACCTGGTGTATCGAGGCTGCAGCTCGGATCCGAGAGGGCATGGCCGCCCTGCAGTCTGACCCCTGGCAGC
AAGAGCTCTACCGCAACTTCAAAAGCATCTCCAAGGCCTTGGTGGAGCGGGGTGGTGTGGTCACCAGCAACCCACTTGGCTTCTGAATAC
TCCCGGCCAGGGCCTGTCCCAGTTATGTGCCTTCCCTCAAGCCAAAGCCGAAGCCCCTTTCCTTAAGGCCCTGGTTTGTCCCGAAGGGGC

>96757_96757_1_ULK2-ACADVL_ULK2_chr17_19741814_ENST00000361658_ACADVL_chr17_7123441_ENST00000350303_length(amino acids)=606AA_BP=
MGQPRPGPARRPYAGGAAQESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPAKNDALEMVEETTWQGLKEL
GAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIR
TSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKMGIKASNTAEVFFDGVRVPS
ENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGAT
DFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDKGKELSGLGSALKNPFGNAG
LLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSL

--------------------------------------------------------------
>96757_96757_2_ULK2-ACADVL_ULK2_chr17_19741814_ENST00000361658_ACADVL_chr17_7123441_ENST00000356839_length(transcript)=3388nt_BP=1306nt
AGTCGCGCGGGAGCGGGTAGCGCGCGCGAGGGCGTTGGGCGCCGCCGCGAGGCGGGGAAGCGCGGGGCCGCGGCGGTGCGGGTTCTAGGG
CGGCGGCCGTCGCCGTCGCAGCAGCGCCCCGAGCGGGGAGGGCCGAGGAGGCCCGACGAGCTGGGGATGGAGAGTACCGGGCCCCTCACT
GCCTCAGAGCGCGTGTGCGGCTCTGGGCGCGCACAGTGACGGTGACGGCACCCCTGGCCCGGCAGCGCCGAGGCCGCTTCGCCAGACAGC
CAGCGGCCGGCGGCAGGCCGGGCCATGAGCGGCAGGGGCCGGGCCGGGCCTCGCTGACCCTGGCTCCGCGCGGCAGCTTCCCCAGTTTCC
GCTCCGGTCTCTCGGCATGAGAGTCCGCCCGGGCCCGGGGCTGCGGCTGCCCCAGACCCGCCGCACGCTGGCGCGCTCCGGGCCCGCGGA
GCCGCGGTGCTGATACCTGCGCCGCACTGCGCCGCCCGCCCGTCCGCTGTGTGCCCCGGGGGCGCGGCCATGGAGGTGGTGGGTGACTTC
GAGTACAGCAAGAGGGATCTCGTGGGACACGGGGCCTTCGCCGTGGTCTTCCGGGGGCGGCACCGCCAGAAAACTGATTGGGAGGTAGCT
ATTAAAAGTATTAATAAAAAGAACTTGTCAAAATCACAAATACTGCTTGGAAAGGAAATTAAAATCTTAAAGGAACTTCAGCATGAAAAT
ATTGTAGCACTCTATGATGTTCAGGAATTACCCAACTCTGTCTTTTTGGTGATGGAGTATTGCAATGGTGGAGACCTCGCAGATTATTTG
CAAGCGAAAGGGACTCTCAGTGAAGACACGATCAGAGTGTTTCTGCATCAGATTGCTGCTGCCATGCGAATCCTGCACAGCAAAGGAATC
ATCCACAGAGATCTCAAACCACAGAACATCTTGCTGTCCTATGCCAATCGCAGAAAATCAAGTGTCAGTGGTATTCGCATCAAAATAGCG
GATTTTGGTTTTGCTCGTTACCTACATAGTAACATGATGGCTGCAACACTGTGTGGATCCCCGATGTACATGGCTCCTGAGGTTATTATG
TCTCAACATTATGATGCTAAGGCTGACTTGTGGAGCATAGGAACAGTGATATACCAATGCCTAGTTGGAAAACCACCTTTTCAGGCCAAT
AGTCCTCAAGACTTAAGGATGTTTTATGAAAAAAACAGGAGCTTAATGCCTAGTATTCCCAGAGAAACATCACCTTATTTGGCTAATCTC
CTTTTGGGTTTGCTTCAGAGAAACCAAAAAGATAGAATGGACTTTGCTCGCGGCTCACGGCGCTCCTGGGGCAGCCCCGGCCCGGCCCTG
CCCGGCGGCCCTATGCCGGGGGTGCCGCTCAGCTGGCTCTGGACAAGTCAGATTCCCACCCCTCTGACGCTCTGACCAGGAAAAAACCGG
CCAAGGCGGAATCTAAGTCCTTTGCTGTGGGAATGTTCAAAGGCCAGCTCACCACAGATCAGGTGTTCCCATACCCGTCCGTGCTCAACG
AAGAGCAGACACAGTTTCTTAAAGAGCTGGTGGAGCCTGTGTCCCGTTTCTTCGAGGAAGTGAACGATCCCGCCAAGAATGACGCTCTGG
AGATGGTGGAGGAGACCACTTGGCAGGGCCTCAAGGAGCTGGGGGCCTTTGGTCTGCAAGTGCCCAGTGAGCTGGGTGGTGTGGGCCTTT
GCAACACCCAGTACGCCCGTTTGGTGGAGATCGTGGGCATGCATGACCTTGGCGTGGGCATTACCCTGGGGGCCCATCAGAGCATCGGTT
TCAAAGGCATCCTGCTCTTTGGCACAAAGGCCCAGAAAGAAAAATACCTCCCCAAGCTGGCATCTGGGGAGACTGTGGCCGCTTTCTGTC
TAACCGAGCCCTCAAGCGGGTCAGATGCAGCCTCCATCCGAACCTCTGCTGTGCCCAGCCCCTGTGGAAAATACTATACCCTCAATGGAA
GCAAGCTTTGGATCAGTAATGGGGGCCTAGCAGACATCTTCACGGTCTTTGCCAAGACACCAGTTACAGATCCAGCCACAGGAGCCGTGA
AGGAGAAGATCACAGCTTTTGTGGTGGAGAGGGGCTTCGGGGGCATTACCCATGGGCCCCCTGAGAAGAAGATGGGCATCAAGGCTTCAA
ACACAGCAGAGGTGTTCTTTGATGGAGTACGGGTGCCATCGGAGAACGTGCTGGGTGAGGTTGGGAGTGGCTTCAAGGTTGCCATGCACA
TCCTCAACAATGGAAGGTTTGGCATGGCTGCGGCCCTGGCAGGTACCATGAGAGGCATCATTGCTAAGGCGGTAGATCATGCCACTAATC
GTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAGGAGAAGCTGGCACGGATGGTTATGCTGCAGTATGTAACTGAGTCCA
TGGCTTACATGGTGAGTGCTAACATGGACCAGGGAGCCACGGACTTCCAGATAGAGGCCGCCATCAGCAAAATCTTTGGCTCGGAGGCAG
CCTGGAAGGTGACAGATGAATGCATCCAAATCATGGGGGGTATGGGCTTCATGAAGGAACCTGGAGTAGAGCGTGTGCTCCGAGATCTTC
GCATCTTCCGGATCTTTGAGGGGACAAATGACATTCTTCGGCTGTTTGTGGCTCTGCAGGGCTGTATGGACAAAGGAAAGGAGCTCTCTG
GGCTTGGCAGTGCTCTAAAGAATCCCTTTGGGAATGCTGGCCTCCTGCTAGGAGAGGCAGGCAAACAGCTGAGGCGGCGGGCAGGGCTGG
GCAGCGGCCTGAGTCTCAGCGGACTTGTCCACCCGGAGTTGAGTCGGAGTGGCGAGCTGGCAGTACGGGCTCTGGAGCAGTTTGCCACTG
TGGTGGAGGCCAAGCTGATAAAACACAAGAAGGGGATTGTCAATGAACAGTTTCTGCTGCAGCGGCTGGCAGACGGGGCCATCGACCTCT
ATGCCATGGTGGTGGTTCTCTCGAGGGCCTCAAGATCCCTGAGTGAGGGCCACCCCACGGCCCAGCATGAGAAAATGCTCTGTGACACCT
GGTGTATCGAGGCTGCAGCTCGGATCCGAGAGGGCATGGCCGCCCTGCAGTCTGACCCCTGGCAGCAAGAGCTCTACCGCAACTTCAAAA
GCATCTCCAAGGCCTTGGTGGAGCGGGGTGGTGTGGTCACCAGCAACCCACTTGGCTTCTGAATACTCCCGGCCAGGGCCTGTCCCAGTT
ATGTGCCTTCCCTCAAGCCAAAGCCGAAGCCCCTTTCCTTAAGGCCCTGGTTTGTCCCGAAGGGGCCTAGTGTTCCCAGCACTGTGCCTG

>96757_96757_2_ULK2-ACADVL_ULK2_chr17_19741814_ENST00000361658_ACADVL_chr17_7123441_ENST00000356839_length(amino acids)=628AA_BP=
MGQPRPGPARRPYAGGAAQLALDKSDSHPSDALTRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVN
DPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLAS
GETVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPE
KKMGIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMV
MLQYVTESMAYMVSANMDQGATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGC
MDKGKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLLQR

--------------------------------------------------------------
>96757_96757_3_ULK2-ACADVL_ULK2_chr17_19741814_ENST00000361658_ACADVL_chr17_7123441_ENST00000543245_length(transcript)=3381nt_BP=1306nt
AGTCGCGCGGGAGCGGGTAGCGCGCGCGAGGGCGTTGGGCGCCGCCGCGAGGCGGGGAAGCGCGGGGCCGCGGCGGTGCGGGTTCTAGGG
CGGCGGCCGTCGCCGTCGCAGCAGCGCCCCGAGCGGGGAGGGCCGAGGAGGCCCGACGAGCTGGGGATGGAGAGTACCGGGCCCCTCACT
GCCTCAGAGCGCGTGTGCGGCTCTGGGCGCGCACAGTGACGGTGACGGCACCCCTGGCCCGGCAGCGCCGAGGCCGCTTCGCCAGACAGC
CAGCGGCCGGCGGCAGGCCGGGCCATGAGCGGCAGGGGCCGGGCCGGGCCTCGCTGACCCTGGCTCCGCGCGGCAGCTTCCCCAGTTTCC
GCTCCGGTCTCTCGGCATGAGAGTCCGCCCGGGCCCGGGGCTGCGGCTGCCCCAGACCCGCCGCACGCTGGCGCGCTCCGGGCCCGCGGA
GCCGCGGTGCTGATACCTGCGCCGCACTGCGCCGCCCGCCCGTCCGCTGTGTGCCCCGGGGGCGCGGCCATGGAGGTGGTGGGTGACTTC
GAGTACAGCAAGAGGGATCTCGTGGGACACGGGGCCTTCGCCGTGGTCTTCCGGGGGCGGCACCGCCAGAAAACTGATTGGGAGGTAGCT
ATTAAAAGTATTAATAAAAAGAACTTGTCAAAATCACAAATACTGCTTGGAAAGGAAATTAAAATCTTAAAGGAACTTCAGCATGAAAAT
ATTGTAGCACTCTATGATGTTCAGGAATTACCCAACTCTGTCTTTTTGGTGATGGAGTATTGCAATGGTGGAGACCTCGCAGATTATTTG
CAAGCGAAAGGGACTCTCAGTGAAGACACGATCAGAGTGTTTCTGCATCAGATTGCTGCTGCCATGCGAATCCTGCACAGCAAAGGAATC
ATCCACAGAGATCTCAAACCACAGAACATCTTGCTGTCCTATGCCAATCGCAGAAAATCAAGTGTCAGTGGTATTCGCATCAAAATAGCG
GATTTTGGTTTTGCTCGTTACCTACATAGTAACATGATGGCTGCAACACTGTGTGGATCCCCGATGTACATGGCTCCTGAGGTTATTATG
TCTCAACATTATGATGCTAAGGCTGACTTGTGGAGCATAGGAACAGTGATATACCAATGCCTAGTTGGAAAACCACCTTTTCAGGCCAAT
AGTCCTCAAGACTTAAGGATGTTTTATGAAAAAAACAGGAGCTTAATGCCTAGTATTCCCAGAGAAACATCACCTTATTTGGCTAATCTC
CTTTTGGGTTTGCTTCAGAGAAACCAAAAAGATAGAATGGACTTTGCTCGCGGCTCACGGCGCTCCTGGGGCAGCCCCGGCCCGGCCCTG
CCCGGCGGCCCTATGCCGGGGGTGCCGCTCAGCTGGCTCTGGACAAGTCAGATTCCCACCCCTCTGACGCTCTGACCAGGAAAAAACCGG
CCAAGGCGGAATCTAAGTCCTTTGCTGTGGGAATGTTCAAAGGCCAGCTCACCACAGATCAGGTGTTCCCATACCCGTCCGTGCTCAACG
AAGAGCAGACACAGTTTCTTAAAGAGCTGGTGGAGCCTGTGTCCCGTTTCTTCGAGGAAGTGAACGATCCCGCCAAGAATGACGCTCTGG
AGATGGTGGAGGAGACCACTTGGCAGGGCCTCAAGGAGCTGGGGGCCTTTGGTCTGCAAGTGCCCAGTGAGCTGGGTGGTGTGGGCCTTT
GCAACACCCAGTACGCCCGTTTGGTGGAGATCGTGGGCATGCATGACCTTGGCGTGGGCATTACCCTGGGGGCCCATCAGAGCATCGGTT
TCAAAGGCATCCTGCTCTTTGGCACAAAGGCCCAGAAAGAAAAATACCTCCCCAAGCTGGCATCTGGGGAGACTGTGGCCGCTTTCTGTC
TAACCGAGCCCTCAAGCGGGTCAGATGCAGCCTCCATCCGAACCTCTGCTGTGCCCAGCCCCTGTGGAAAATACTATACCCTCAATGGAA
GCAAGCTTTGGATCAGTAATGGGGGCCTAGCAGACATCTTCACGGTCTTTGCCAAGACACCAGTTACAGATCCAGCCACAGGAGCCGTGA
AGGAGAAGATCACAGCTTTTGTGGTGGAGAGGGGCTTCGGGGGCATTACCCATGGGCCCCCTGAGAAGAAGATGGGCATCAAGGCTTCAA
ACACAGCAGAGGTGTTCTTTGATGGAGTACGGGTGCCATCGGAGAACGTGCTGGGTGAGGTTGGGAGTGGCTTCAAGGTTGCCATGCACA
TCCTCAACAATGGAAGGTTTGGCATGGCTGCGGCCCTGGCAGGTACCATGAGAGGCATCATTGCTAAGGCGGTAGATCATGCCACTAATC
GTACCCAGTTTGGGGAGAAAATTCACAACTTTGGGCTGATCCAGGAGAAGCTGGCACGGATGGTTATGCTGCAGTATGTAACTGAGTCCA
TGGCTTACATGGTGAGTGCTAACATGGACCAGGGAGCCACGGACTTCCAGATAGAGGCCGCCATCAGCAAAATCTTTGGCTCGGAGGCAG
CCTGGAAGGTGACAGATGAATGCATCCAAATCATGGGGGGTATGGGCTTCATGAAGGAACCTGGAGTAGAGCGTGTGCTCCGAGATCTTC
GCATCTTCCGGATCTTTGAGGGGACAAATGACATTCTTCGGCTGTTTGTGGCTCTGCAGGGCTGTATGGACAAAGGAAAGGAGCTCTCTG
GGCTTGGCAGTGCTCTAAAGAATCCCTTTGGGAATGCTGGCCTCCTGCTAGGAGAGGCAGGCAAACAGCTGAGGCGGCGGGCAGGGCTGG
GCAGCGGCCTGAGTCTCAGCGGACTTGTCCACCCGGAGTTGAGTCGGAGTGGCGAGCTGGCAGTACGGGCTCTGGAGCAGTTTGCCACTG
TGGTGGAGGCCAAGCTGATAAAACACAAGAAGGGGATTGTCAATGAACAGTTTCTGCTGCAGCGGCTGGCAGACGGGGCCATCGACCTCT
ATGCCATGGTGGTGGTTCTCTCGAGGGCCTCAAGATCCCTGAGTGAGGGCCACCCCACGGCCCAGCATGAGAAAATGCTCTGTGACACCT
GGTGTATCGAGGCTGCAGCTCGGATCCGAGAGGGCATGGCCGCCCTGCAGTCTGACCCCTGGCAGCAAGAGCTCTACCGCAACTTCAAAA
GCATCTCCAAGGCCTTGGTGGAGCGGGGTGGTGTGGTCACCAGCAACCCACTTGGCTTCTGAATACTCCCGGCCAGGGCCTGTCCCAGTT
ATGTGCCTTCCCTCAAGCCAAAGCCGAAGCCCCTTTCCTTAAGGCCCTGGTTTGTCCCGAAGGGGCCTAGTGTTCCCAGCACTGTGCCTG

>96757_96757_3_ULK2-ACADVL_ULK2_chr17_19741814_ENST00000361658_ACADVL_chr17_7123441_ENST00000543245_length(amino acids)=628AA_BP=
MGQPRPGPARRPYAGGAAQLALDKSDSHPSDALTRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVN
DPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLAS
GETVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPE
KKMGIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMV
MLQYVTESMAYMVSANMDQGATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGC
MDKGKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLLQR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ULK2-ACADVL

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ULK2-ACADVL

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ULK2-ACADVL

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source