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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UNKL-STX1B (FusionGDB2 ID:96892)

Fusion Gene Summary for UNKL-STX1B

check button Fusion gene summary
Fusion gene informationFusion gene name: UNKL-STX1B
Fusion gene ID: 96892
HgeneTgene
Gene symbol

UNKL

STX1B

Gene ID

64718

112755

Gene nameunk like zinc fingersyntaxin 1B
SynonymsC16orf28|ZC3H5L|ZC3HDC5LGEFSP9|STX1B1|STX1B2
Cytomap

16p13.3

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionputative E3 ubiquitin-protein ligase UNKLRING finger protein unkempt-likeunkempt family zinc finger-likeunkempt homolog-likezinc finger CCCH domain-containing protein 5-likesyntaxin-1Bsyntaxin-1B1syntaxin-1B2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000389221, ENST00000397462, 
ENST00000508903, ENST00000248104, 
ENST00000301712, ENST00000391893, 
ENST00000397464, ENST00000402641, 
ENST00000403703, ENST00000503648, 
ENST00000215095, ENST00000565419, 
Fusion gene scores* DoF score8 X 7 X 5=2802 X 2 X 2=8
# samples 82
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: UNKL [Title/Abstract] AND STX1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUNKL(1440633)-STX1B(31012924), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across UNKL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STX1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-F5-6811-01AUNKLchr16

1440633

-STX1Bchr16

31012924

-
ChimerDB4READTCGA-F5-6811UNKLchr16

1440633

-STX1Bchr16

31012924

-


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Fusion Gene ORF analysis for UNKL-STX1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000389221ENST00000215095UNKLchr16

1440633

-STX1Bchr16

31012924

-
In-frameENST00000389221ENST00000565419UNKLchr16

1440633

-STX1Bchr16

31012924

-
In-frameENST00000397462ENST00000215095UNKLchr16

1440633

-STX1Bchr16

31012924

-
In-frameENST00000397462ENST00000565419UNKLchr16

1440633

-STX1Bchr16

31012924

-
In-frameENST00000508903ENST00000215095UNKLchr16

1440633

-STX1Bchr16

31012924

-
In-frameENST00000508903ENST00000565419UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000248104ENST00000215095UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000248104ENST00000565419UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000301712ENST00000215095UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000301712ENST00000565419UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000391893ENST00000215095UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000391893ENST00000565419UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000397464ENST00000215095UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000397464ENST00000565419UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000402641ENST00000215095UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000402641ENST00000565419UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000403703ENST00000215095UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000403703ENST00000565419UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000503648ENST00000215095UNKLchr16

1440633

-STX1Bchr16

31012924

-
intron-3CDSENST00000503648ENST00000565419UNKLchr16

1440633

-STX1Bchr16

31012924

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000389221UNKLchr161440633-ENST00000215095STX1Bchr1631012924-5479107701913637
ENST00000389221UNKLchr161440633-ENST00000565419STX1Bchr1631012924-2255107701880626
ENST00000508903UNKLchr161440633-ENST00000215095STX1Bchr1631012924-5488108601922640
ENST00000508903UNKLchr161440633-ENST00000565419STX1Bchr1631012924-2264108601889629
ENST00000397462UNKLchr161440633-ENST00000215095STX1Bchr1631012924-6057165522491829
ENST00000397462UNKLchr161440633-ENST00000565419STX1Bchr1631012924-2833165522458818

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389221ENST00000215095UNKLchr161440633-STX1Bchr1631012924-0.0024993980.9975006
ENST00000389221ENST00000565419UNKLchr161440633-STX1Bchr1631012924-0.0224547520.97754526
ENST00000508903ENST00000215095UNKLchr161440633-STX1Bchr1631012924-0.0025818230.99741817
ENST00000508903ENST00000565419UNKLchr161440633-STX1Bchr1631012924-0.0218982960.9781017
ENST00000397462ENST00000215095UNKLchr161440633-STX1Bchr1631012924-0.0022643120.9977356
ENST00000397462ENST00000565419UNKLchr161440633-STX1Bchr1631012924-0.0122614490.9877386

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Fusion Genomic Features for UNKL-STX1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for UNKL-STX1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:1440633/chr16:31012924)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUNKLchr16:1440633chr16:31012924ENST00000389221-91561_64359681.0Compositional biasNote=Poly-Arg
HgeneUNKLchr16:1440633chr16:31012924ENST00000389221-9157_11359681.0Compositional biasNote=Poly-Ala
HgeneUNKLchr16:1440633chr16:31012924ENST00000397462-131561_64549757.0Compositional biasNote=Poly-Arg
HgeneUNKLchr16:1440633chr16:31012924ENST00000397462-13157_11549757.0Compositional biasNote=Poly-Ala
HgeneUNKLchr16:1440633chr16:31012924ENST00000389221-915115_145359681.0Zinc fingerC3H1-type 2
HgeneUNKLchr16:1440633chr16:31012924ENST00000389221-915243_277359681.0Zinc fingerC3H1-type 3
HgeneUNKLchr16:1440633chr16:31012924ENST00000389221-915283_310359681.0Zinc fingerC3H1-type 4
HgeneUNKLchr16:1440633chr16:31012924ENST00000389221-91575_104359681.0Zinc fingerC3H1-type 1
HgeneUNKLchr16:1440633chr16:31012924ENST00000397462-1315115_145549757.0Zinc fingerC3H1-type 2
HgeneUNKLchr16:1440633chr16:31012924ENST00000397462-1315243_277549757.0Zinc fingerC3H1-type 3
HgeneUNKLchr16:1440633chr16:31012924ENST00000397462-1315283_310549757.0Zinc fingerC3H1-type 4
HgeneUNKLchr16:1440633chr16:31012924ENST00000397462-131575_104549757.0Zinc fingerC3H1-type 1
TgeneSTX1Bchr16:1440633chr16:31012924ENST0000021509501029_10410289.0Coiled coilOntology_term=ECO:0000255
TgeneSTX1Bchr16:1440633chr16:31012924ENST000005654190929_10410278.0Coiled coilOntology_term=ECO:0000255
TgeneSTX1Bchr16:1440633chr16:31012924ENST00000215095010191_25310289.0Domaint-SNARE coiled-coil homology
TgeneSTX1Bchr16:1440633chr16:31012924ENST0000056541909191_25310278.0Domaint-SNARE coiled-coil homology
TgeneSTX1Bchr16:1440633chr16:31012924ENST00000215095010265_28810289.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneSTX1Bchr16:1440633chr16:31012924ENST0000056541909265_28810278.0TransmembraneHelical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUNKLchr16:1440633chr16:31012924ENST00000248104-16563_6190230.0Coiled coilOntology_term=ECO:0000255
HgeneUNKLchr16:1440633chr16:31012924ENST00000301712-16563_6190278.0Coiled coilOntology_term=ECO:0000255
HgeneUNKLchr16:1440633chr16:31012924ENST00000389221-915563_619359681.0Coiled coilOntology_term=ECO:0000255
HgeneUNKLchr16:1440633chr16:31012924ENST00000391893-14563_6190230.0Coiled coilOntology_term=ECO:0000255
HgeneUNKLchr16:1440633chr16:31012924ENST00000397462-1315563_619549757.0Coiled coilOntology_term=ECO:0000255
HgeneUNKLchr16:1440633chr16:31012924ENST00000397464-16563_6190183.0Coiled coilOntology_term=ECO:0000255
HgeneUNKLchr16:1440633chr16:31012924ENST00000402641-16563_6190233.0Coiled coilOntology_term=ECO:0000255
HgeneUNKLchr16:1440633chr16:31012924ENST00000403703-16563_6190233.0Coiled coilOntology_term=ECO:0000255
HgeneUNKLchr16:1440633chr16:31012924ENST00000248104-16374_5610230.0Compositional biasNote=Ser-rich
HgeneUNKLchr16:1440633chr16:31012924ENST00000248104-1661_640230.0Compositional biasNote=Poly-Arg
HgeneUNKLchr16:1440633chr16:31012924ENST00000248104-167_110230.0Compositional biasNote=Poly-Ala
HgeneUNKLchr16:1440633chr16:31012924ENST00000301712-16374_5610278.0Compositional biasNote=Ser-rich
HgeneUNKLchr16:1440633chr16:31012924ENST00000301712-1661_640278.0Compositional biasNote=Poly-Arg
HgeneUNKLchr16:1440633chr16:31012924ENST00000301712-167_110278.0Compositional biasNote=Poly-Ala
HgeneUNKLchr16:1440633chr16:31012924ENST00000389221-915374_561359681.0Compositional biasNote=Ser-rich
HgeneUNKLchr16:1440633chr16:31012924ENST00000391893-14374_5610230.0Compositional biasNote=Ser-rich
HgeneUNKLchr16:1440633chr16:31012924ENST00000391893-1461_640230.0Compositional biasNote=Poly-Arg
HgeneUNKLchr16:1440633chr16:31012924ENST00000391893-147_110230.0Compositional biasNote=Poly-Ala
HgeneUNKLchr16:1440633chr16:31012924ENST00000397462-1315374_561549757.0Compositional biasNote=Ser-rich
HgeneUNKLchr16:1440633chr16:31012924ENST00000397464-16374_5610183.0Compositional biasNote=Ser-rich
HgeneUNKLchr16:1440633chr16:31012924ENST00000397464-1661_640183.0Compositional biasNote=Poly-Arg
HgeneUNKLchr16:1440633chr16:31012924ENST00000397464-167_110183.0Compositional biasNote=Poly-Ala
HgeneUNKLchr16:1440633chr16:31012924ENST00000402641-16374_5610233.0Compositional biasNote=Ser-rich
HgeneUNKLchr16:1440633chr16:31012924ENST00000402641-1661_640233.0Compositional biasNote=Poly-Arg
HgeneUNKLchr16:1440633chr16:31012924ENST00000402641-167_110233.0Compositional biasNote=Poly-Ala
HgeneUNKLchr16:1440633chr16:31012924ENST00000403703-16374_5610233.0Compositional biasNote=Ser-rich
HgeneUNKLchr16:1440633chr16:31012924ENST00000403703-1661_640233.0Compositional biasNote=Poly-Arg
HgeneUNKLchr16:1440633chr16:31012924ENST00000403703-167_110233.0Compositional biasNote=Poly-Ala
HgeneUNKLchr16:1440633chr16:31012924ENST00000248104-16115_1450230.0Zinc fingerC3H1-type 2
HgeneUNKLchr16:1440633chr16:31012924ENST00000248104-16243_2770230.0Zinc fingerC3H1-type 3
HgeneUNKLchr16:1440633chr16:31012924ENST00000248104-16283_3100230.0Zinc fingerC3H1-type 4
HgeneUNKLchr16:1440633chr16:31012924ENST00000248104-16639_6740230.0Zinc fingerRING-type
HgeneUNKLchr16:1440633chr16:31012924ENST00000248104-1675_1040230.0Zinc fingerC3H1-type 1
HgeneUNKLchr16:1440633chr16:31012924ENST00000301712-16115_1450278.0Zinc fingerC3H1-type 2
HgeneUNKLchr16:1440633chr16:31012924ENST00000301712-16243_2770278.0Zinc fingerC3H1-type 3
HgeneUNKLchr16:1440633chr16:31012924ENST00000301712-16283_3100278.0Zinc fingerC3H1-type 4
HgeneUNKLchr16:1440633chr16:31012924ENST00000301712-16639_6740278.0Zinc fingerRING-type
HgeneUNKLchr16:1440633chr16:31012924ENST00000301712-1675_1040278.0Zinc fingerC3H1-type 1
HgeneUNKLchr16:1440633chr16:31012924ENST00000389221-915639_674359681.0Zinc fingerRING-type
HgeneUNKLchr16:1440633chr16:31012924ENST00000391893-14115_1450230.0Zinc fingerC3H1-type 2
HgeneUNKLchr16:1440633chr16:31012924ENST00000391893-14243_2770230.0Zinc fingerC3H1-type 3
HgeneUNKLchr16:1440633chr16:31012924ENST00000391893-14283_3100230.0Zinc fingerC3H1-type 4
HgeneUNKLchr16:1440633chr16:31012924ENST00000391893-14639_6740230.0Zinc fingerRING-type
HgeneUNKLchr16:1440633chr16:31012924ENST00000391893-1475_1040230.0Zinc fingerC3H1-type 1
HgeneUNKLchr16:1440633chr16:31012924ENST00000397462-1315639_674549757.0Zinc fingerRING-type
HgeneUNKLchr16:1440633chr16:31012924ENST00000397464-16115_1450183.0Zinc fingerC3H1-type 2
HgeneUNKLchr16:1440633chr16:31012924ENST00000397464-16243_2770183.0Zinc fingerC3H1-type 3
HgeneUNKLchr16:1440633chr16:31012924ENST00000397464-16283_3100183.0Zinc fingerC3H1-type 4
HgeneUNKLchr16:1440633chr16:31012924ENST00000397464-16639_6740183.0Zinc fingerRING-type
HgeneUNKLchr16:1440633chr16:31012924ENST00000397464-1675_1040183.0Zinc fingerC3H1-type 1
HgeneUNKLchr16:1440633chr16:31012924ENST00000402641-16115_1450233.0Zinc fingerC3H1-type 2
HgeneUNKLchr16:1440633chr16:31012924ENST00000402641-16243_2770233.0Zinc fingerC3H1-type 3
HgeneUNKLchr16:1440633chr16:31012924ENST00000402641-16283_3100233.0Zinc fingerC3H1-type 4
HgeneUNKLchr16:1440633chr16:31012924ENST00000402641-16639_6740233.0Zinc fingerRING-type
HgeneUNKLchr16:1440633chr16:31012924ENST00000402641-1675_1040233.0Zinc fingerC3H1-type 1
HgeneUNKLchr16:1440633chr16:31012924ENST00000403703-16115_1450233.0Zinc fingerC3H1-type 2
HgeneUNKLchr16:1440633chr16:31012924ENST00000403703-16243_2770233.0Zinc fingerC3H1-type 3
HgeneUNKLchr16:1440633chr16:31012924ENST00000403703-16283_3100233.0Zinc fingerC3H1-type 4
HgeneUNKLchr16:1440633chr16:31012924ENST00000403703-16639_6740233.0Zinc fingerRING-type
HgeneUNKLchr16:1440633chr16:31012924ENST00000403703-1675_1040233.0Zinc fingerC3H1-type 1
TgeneSTX1Bchr16:1440633chr16:31012924ENST000002150950101_26410289.0Topological domainCytoplasmic
TgeneSTX1Bchr16:1440633chr16:31012924ENST00000565419091_26410278.0Topological domainCytoplasmic


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Fusion Gene Sequence for UNKL-STX1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96892_96892_1_UNKL-STX1B_UNKL_chr16_1440633_ENST00000389221_STX1B_chr16_31012924_ENST00000215095_length(transcript)=5479nt_BP=1077nt
ATGCCGTCGGTTTCGAAAGCGGCGGCAGCGGCGCTGAGCGGGTCCCCCCCGCAGACTGAGAAGCCGACCCACTACAGGTACCTGAAGGAG
TTCAGGACGGAGCAGTGCCCCCTGTTTTCACAGCACAAGTGCGCGCAGCACCGGCCGTTCACCTGCTTCCACTGGCACTTCCTCAACCAG
CGGCGCCGCAGGCCCCTCCGCAGGCGCGACGGCACCTTCAACTACAGCCCCGACGTGTACTGCTCCAAGTACAACGAAGCCACCGGCGTG
TGCCCCGACGGCGACGAGTGTCCCTACCTGCACCGGACGACGGGGGACACAGAACGCAAGTACCACCTGCGTTACTACAAAACAGGAACC
TGCATCCACGAGACAGACGCACGTGGCCACTGCGTGAAGAATGGGCTGCACTGTGCCTTCGCGCACGGCCCCCTGGACCTGCGGCCGCCC
GTGTGTGACGTCAGGGAGCTGCAGGCCCAGGAAGCCTTGCAGAACGGCCAGCTGGGCGGCGGGGAAGGGGTCCCGGATCTGCAGCCTGGG
GTCTTGGCCAGCCAGGCCATGATTGAGAAGATCCTGAGCGAGGACCCCCGGTGGCAAGATGCCAACTTCGTGCTGGGCAGCTACAAGACG
GAGCAGTGCCCGAAGCCGCCACGCCTGTGCCGCCAGGGCTATGCGTGCCCACACTACCACAATAGCCGGGACAGGCGGCGCAACCCCCGG
CGGTTCCAGTACAGGTCCACGCCCTGCCCCAGTGTGAAGCACGGGGATGAGTGGGGGGAACCCTCACGCTGCGATGGCGGCGACGGCTGC
CAGTATTGCCACTCCCGCACGGAGCAGCAGTTCCATCCCGAGTCTACAAAATGCAACGACATGCGCCAAACCGGGTACTGCCCGCGCGGC
CCCTTCTGTGCCTTTGCACACGTTGAGAAGAGCCTGGGGATGGTGAATGAATGGGGCTGTCACGACCTCCACCTCACGAGTCCTTCCTCC
ACGGGCAGCGGCCAGCCGGGAAATGCCAAGCGGAGAGACTCGCCGGCCGAGGGTGGCCCTAGGGGCAGCGAGCAAGACAGCAAGCAGGCG
AAAGACAGTGATGATGAAGAGGAGGTGGTCCACGTGGATCGGGACCACTTCATGGATGAGTTCTTTGAACAGGTGGAAGAGATCCGGGGC
TGCATTGAGAAACTGTCGGAGGATGTGGAGCAGGTGAAAAAACAGCATAGCGCCATCCTGGCCGCACCCAACCCAGATGAGAAGACCAAA
CAGGAGCTGGAGGATCTCACTGCAGACATCAAGAAGACGGCCAACAAGGTTCGGTCCAAATTGAAAGCGATCGAGCAAAGCATTGAACAG
GAGGAGGGGCTGAACCGTTCCTCCGCGGACCTGCGCATCCGCAAGACCCAGCACTCCACACTGTCCCGGAAGTTCGTGGAGGTAATGACC
GAATATAACGCGACCCAGTCCAAGTACCGGGACCGCTGCAAGGACCGGATCCAGCGGCAACTGGAGATCACTGGAAGGACCACCACCAAC
GAAGAACTGGAAGACATGCTGGAGAGCGGGAAGCTGGCCATCTTCACAGATGACATCAAAATGGACTCACAGATGACGAAGCAGGCGCTG
AATGAGATTGAGACGAGGCACAATGAGATCATCAAGCTGGAGACCAGCATCCGCGAGCTGCACGATATGTTTGTGGACATGGCCATGCTC
GTAGAGAGCCAGGGAGAGATGATTGACCGCATCGAGTACAACGTGGAACATTCTGTGGACTACGTGGAGCGAGCTGTGTCTGACACCAAG
AAAGCAGTGAAATATCAGAGCAAGGCCCGGAGGAAGAAAATCATGATCATCATTTGCTGTGTGGTGCTGGGGGTGGTCTTGGCGTCATCC
ATTGGGGGGACGCTGGGCTTGTAGGCCCCCCCCACCCTTCTCTCTCCCAGACCCTTCCCCCACCACATCGGGAGCAATACCCCCACCACC
CCTTTCACTCCATCCCCTGCTCCAGGCTCACTCCCAAAACAGACCCAGGCAGCCCCACCCCCACGGCAGACCCTGGTGTCCCTGGACCTC
ACCGGGCCATGGACCCCCCCCCCGTCCCCGCACGTAGATCGCAGCAGGCGTGATTACACATGCACACCAACATGCATGCCGCCGGCACAT
GCTCGAGACGTGTGGACACCCCAGCGTGCGTGTGCGTGTGATGTGTGTGATGCACCAGAGCACCCCCTCCACCCCCACCTTGGGTGTGTG
TGCGTGGTCTGAGCTTCCCCCTTCACCGGGGCTGTTGTGTAGACTGCAGCCAAGTGTAACACAGCAGTCCATCACGCCCTCTCTGTCCTC
TGTGAACAGTGTGTGTGCGTGCGTGAGACCACAGATCTGTGGACACACCATTTGTGTACGTGGAATTTTGTGTTTCAGTGTTTGAACCTA
ATGCAACAGCAACAAAGCCACTGATACCTGAGCCCTTTGTGTCTGCTACAAACCAGGCAGGTGGTGTGTGTGGACTCACACTCACATTCT
CAGAGGATCCAGGGAGGCCCAGGTACACACAGGCCATGGCAGACACCCCATGTCTTTGTTACCCCAGGGGCTGTGGCATGTCCCAGGAGG
GTGTGCATGTGTGTGTGTGTGTGTGTGTGTGTGTCCAGGATGTGCCTGAAGTATTGATAGGTCTTCTCAGATAGAGCCCTCCACACTGTG
GACTGGACACCTGTTTTGGGAGGGCACAGAAATGTGTATTTCTTGCTACCTAGAATGCAGCTGTGTGTGTGTGGCGTGCGTGTGTATGCA
CGTGTGTGTGTGTGTTAGGGGCTCTCTACATGGTGTGCTTTTTAATTTTTTTTTGTTTTTTGTTTTTTGTTTTTTTCGAGACGGAGTCTT
GCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTGTGCCTCCCTGACGCAAGCGATTCTCATGCCTCAGCC
TCCCAAGTAGCTGGGACTACAGGCGCCTGCCACCACGCCTGGCTAATTTTAGAATTTTAGTAGAGATGAGGTTTTGACATGTTGGCCAGG
CTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCCACTTTGGCCTCCCTAAGTGCTGGCATTACAGGCCTGAGCCACCACGCCTGGCCTA
CATGATGTGTTTCTGTCCTGCCTGACCTACATGGTGTGTTTCTGCCCTGCGTATTACACACACACACACACACGTGCGTGCACACACACT
TCTAAGGACGTGGCCCCATCTGGCTTTGTCTCTCCAGTTGTCCTTGCCCTGCCCCCCTCCCCAGAGGTGCTGCCCAGTGCTGGTGTGGCC
ACACACGGCTACATCATTGTGCAGGCAGAGCTCCCTGCCTGCCCAGCCTCAGGGCTCTGCATGCTCACACCTAGATCCTCATCTTCCTCC
ATGTCTCTGCCCAGCATAGCCCCGAGCCCCTGGAAGCTGGTACCCCTCAGTGTGCTCACACGTGGCAAGGCCGAGGTGGCCCCAGGCAGG
GGCCATACCAGGCACAAACCATGCACGCTGGCATGGGTGCGGGGATCACACGAATGCCTCCTGGAAGGAAAGGGCTACTTGTAGGAATGT
TACTGATGAGGCAAGATGCCAAGGACTTCCCTGCAGGGATCAAAGATCAGGACACGACCCCTTCCTCACACACCCACCTCAGACCTGGGA
GAGGACTGTGTGTCCCCCACTGCCCCATCGGATGCTCTGGGCTCTGCCTCAGGGAACTCGGGTTTGGGGAAATGTCTATTTCAGAAGTAC
TGGAGTGGCCAGTGTGGCAGTGGCCACTCAGGGTGGGCTGGGTCCTGAGACCCATCCCCGACACCTCTCCTGCTGAACCCTCAGGCTGCT
CCCCACACCAGGGTGTGACTGAGGGGTACACAGGCCTGGATTTCTGGTGTGAGGAAGGGGCTAGCACCTCCCCTGTTGTGTAGCCAGCAC
AGGCACAATTTGTGGGTTTGGTGGCAGGTAGGTGGTGCGTGGGAGAAAGGACAGTGTTAGAGGTCCCCACTCCGTGGTCTAGGATCATGA
AAGGTGAACACACAAGTACACAAATGTGCCATGCCCTGGCATGGGGCTTATGTGTGCACAGGCAAGGCACTCGGTGTGTGTGTGCGGACC
CCAGGGTCCCAGGTCATGTGAAGCGTACGTGTGTGTGCATTGTATGTGTGTGTACATTGTGTGTGCATTGTGTGTGCATGTGGCCAAACA
GATGTGACCTCCCAGAACACAGTACCCCTCCACCTCTACCCGAGCTCAGACAGCCGAGCTCTCCCTTGTCCTGTGTGTGTGTCAGTGTGG
CCACGTGCGTAACCCCAGGTGGGCTGTCCTGAGCTGGGGGCCTGCCTGTCCCTTCCCAGAACGCCCCTCTGCAGGACAGGAAGTCTGCCC
CAAGTCTGGCCACGGCCCTCCTGCTCCCATCTCGGGCTGCTTGGGAGACATCAGAGCAGGCCCCAGCCCCCAGTCCCCTCTTCCGGCCGC
CTGGACAGGACCCCCATTCAGCCCAGGTGTTTCCGGAAGTCCCACGGCCTTGGGGCCACAGGAGAAGGGTTGAAGCGTGGCTGGGGCACC
ACTCCCCCCACCTGGAGTGGCATTGGGCCCACAGCTGCCCATCTCTGGGCCTCAGGTGGACCAGGGGATCTCTAAGGGTCTGCTGTGCCC
TTTCTATGCGTCCTCCACATCCTATGATGTGCCTGCTTGTTGGCTGCTGTCTGTGTGCGTCCTGGCATGTTGTCTGGAGGCTGGTGTCTT
TTGCATGTTCTTGGACAAATGTGTGCTACCTGCCCAGGCGCCTGCAACCATTGAGCCCACATGTGCCCCACGTGTGCCCTGCGGGTGGTC
CCGGGCCTGGCCAGGGCTCAGTGCTCCTCTTCCCCCTCCTCCCTGTTCCCACCCCTCATGAAGCACACTGCGTGTCCATCCCATGTACCC
GTGGGTCGACACACGCTCTTGCCACGCCCTGAGCGTGTACACATGATGTGTTCTATGCATTCACCCTGCCCCCCAGCCCGCCCTGCAGAG
GACAAGATGGGTGGCCCCGGCTCCCTTTCCCCTAACCGCCCCTGCCCGCTGTGCAGCCGTGTGCGTTGGCGTGTGTTTCTGTGTCACTGG
CGTGTCACGTGATGTAGCCGTGTTTGCTGACATGAGCCCCTGCCCCCTTCTCTGTTTCTCCGTTGGTTTCTAGAGCTCTCTCCCTCCCCT
TCTCAGAGGGGACAGGACTCCTGGGGCCTGGCTGGGGCCCAGAGCCAGGCCGCCCTCTCCTGTTAGCCCTCAGAGTCCCATTTCTGTTAG
CCCTCAGAGTCCCATTTCTATTGGTGACCAACTTGCAAATGGATAAAACACAGGAAAATCCTGCCCCCCCCTTCCTCCCTGCATGTCCTG

>96892_96892_1_UNKL-STX1B_UNKL_chr16_1440633_ENST00000389221_STX1B_chr16_31012924_ENST00000215095_length(amino acids)=637AA_BP=358
MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEATGV
CPDGDECPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPG
VLASQAMIEKILSEDPRWQDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGC
QYCHSRTEQQFHPESTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEGGPRGSEQDSKQA
KDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQSIEQ
EEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTKQAL
NEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVLASS

--------------------------------------------------------------
>96892_96892_2_UNKL-STX1B_UNKL_chr16_1440633_ENST00000389221_STX1B_chr16_31012924_ENST00000565419_length(transcript)=2255nt_BP=1077nt
ATGCCGTCGGTTTCGAAAGCGGCGGCAGCGGCGCTGAGCGGGTCCCCCCCGCAGACTGAGAAGCCGACCCACTACAGGTACCTGAAGGAG
TTCAGGACGGAGCAGTGCCCCCTGTTTTCACAGCACAAGTGCGCGCAGCACCGGCCGTTCACCTGCTTCCACTGGCACTTCCTCAACCAG
CGGCGCCGCAGGCCCCTCCGCAGGCGCGACGGCACCTTCAACTACAGCCCCGACGTGTACTGCTCCAAGTACAACGAAGCCACCGGCGTG
TGCCCCGACGGCGACGAGTGTCCCTACCTGCACCGGACGACGGGGGACACAGAACGCAAGTACCACCTGCGTTACTACAAAACAGGAACC
TGCATCCACGAGACAGACGCACGTGGCCACTGCGTGAAGAATGGGCTGCACTGTGCCTTCGCGCACGGCCCCCTGGACCTGCGGCCGCCC
GTGTGTGACGTCAGGGAGCTGCAGGCCCAGGAAGCCTTGCAGAACGGCCAGCTGGGCGGCGGGGAAGGGGTCCCGGATCTGCAGCCTGGG
GTCTTGGCCAGCCAGGCCATGATTGAGAAGATCCTGAGCGAGGACCCCCGGTGGCAAGATGCCAACTTCGTGCTGGGCAGCTACAAGACG
GAGCAGTGCCCGAAGCCGCCACGCCTGTGCCGCCAGGGCTATGCGTGCCCACACTACCACAATAGCCGGGACAGGCGGCGCAACCCCCGG
CGGTTCCAGTACAGGTCCACGCCCTGCCCCAGTGTGAAGCACGGGGATGAGTGGGGGGAACCCTCACGCTGCGATGGCGGCGACGGCTGC
CAGTATTGCCACTCCCGCACGGAGCAGCAGTTCCATCCCGAGTCTACAAAATGCAACGACATGCGCCAAACCGGGTACTGCCCGCGCGGC
CCCTTCTGTGCCTTTGCACACGTTGAGAAGAGCCTGGGGATGGTGAATGAATGGGGCTGTCACGACCTCCACCTCACGAGTCCTTCCTCC
ACGGGCAGCGGCCAGCCGGGAAATGCCAAGCGGAGAGACTCGCCGGCCGAGGGTGGCCCTAGGGGCAGCGAGCAAGACAGCAAGCAGGCG
AAAGACAGTGATGATGAAGAGGAGGTGGTCCACGTGGATCGGGACCACTTCATGGATGAGTTCTTTGAACAGGTGGAAGAGATCCGGGGC
TGCATTGAGAAACTGTCGGAGGATGTGGAGCAGGTGAAAAAACAGCATAGCGCCATCCTGGCCGCACCCAACCCAGATGAGAAGACCAAA
CAGGAGCTGGAGGATCTCACTGCAGACATCAAGAAGACGGCCAACAAGGTTCGGTCCAAATTGAAAGCGATCGAGCAAAGCATTGAACAG
GAGGAGGGGCTGAACCGTTCCTCCGCGGACCTGCGCATCCGCAAGACCCAGCACTCCACACTGTCCCGGAAGTTCGTGGAGGTAATGACC
GAATATAACGCGACCCAGTCCAAGTACCGGGACCGCTGCAAGGACCGGATCCAGCGGCAACTGGAGATCACTGGAAGGACCACCACCAAC
GAAGAACTGGAAGACATGCTGGAGAGCGGGAAGCTGGCCATCTTCACAGATGACATCAAAATGGACTCACAGATGACGAAGCAGGCGCTG
AATGAGATTGAGACGAGGCACAATGAGATCATCAAGCTGGAGACCAGCATCCGCGAGCTGCACGATATGTTTGTGGACATGGCCATGCTC
GTAGAGAGCCAGGGAGAGATGATTGACCGCATCGAGTACAACGTGGAACATTCTGTGGACTACGTGGAGCGAGCTGTGTCTGACACCAAG
AAAGCAGTGAAATATCAGAGCAAGGCCCGGAGGGTGAGCGGGGCAGGCGGCCTGGGGGTAGGCGGGGGAGCCCAAGGCTGAGCCCGGGCT
GAGGTGAGTGATGGCAGCGGGCGGGAGGCCTTATCTCTGGCTCTGACCTCTTCCTGTTTCTGTTTTCTCTCCCCTCTTCTCCCTGCCACC
CTCTGCCCTGTCTGTCCCTGCATCTGTCCGTGTGTCGATCTCTCTCACTGTCTGCCTGTCTCACTCCTCTTTCTGCTGCAGAAGAAAATC
ATGATCATCATTTGCTGTGTGGTGCTGGGGGTGGTCTTGGCGTCATCCATTGGGGGGACGCTGGGCTTGTAGGCCCCCCCCACCCTTCTC
TCTCCCAGACCCTTCCCCCACCACATCGGGAGCAATACCCCCACCACCCCTTTCACTCCATCCCCTGCTCCAGGCTCACTCCCAAAACAG

>96892_96892_2_UNKL-STX1B_UNKL_chr16_1440633_ENST00000389221_STX1B_chr16_31012924_ENST00000565419_length(amino acids)=626AA_BP=358
MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEATGV
CPDGDECPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPG
VLASQAMIEKILSEDPRWQDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGC
QYCHSRTEQQFHPESTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEGGPRGSEQDSKQA
KDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQSIEQ
EEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTKQAL

--------------------------------------------------------------
>96892_96892_3_UNKL-STX1B_UNKL_chr16_1440633_ENST00000397462_STX1B_chr16_31012924_ENST00000215095_length(transcript)=6057nt_BP=1655nt
GACTGAAAATGCCGTCGGTTTCGAAAGCGGCGGCAGCGGCGCTGAGCGGGTCCCCCCCGCAGACTGAGAAGCCGACCCACTACAGGTACC
TGAAGGAGTTCAGGACGGAGCAGTGCCCCCTGTTTTCACAGCACAAGTGCGCGCAGCACCGGCCGTTCACCTGCTTCCACTGGCACTTCC
TCAACCAGCGGCGCCGCAGGCCCCTCCGCAGGCGCGACGGCACCTTCAACTACAGCCCCGACGTGTACTGCTCCAAGTACAACGAAGCCA
CCGGCGTGTGCCCCGACGGCGACGAGTCACTTCTCGGCGTCCTCTATCCTCTGTGGGCACCCCCTCCGGTGCCTGCCCCCGTGGGTGCCC
CCACTGTGCACCCTTTCCTAGCCCGGTGGTTCTCGCACGTTCCCTGGGAACCAGCCGGCAGTGCAGATCCACGGGCCTCGTCCACACCAG
CTGGGGGGACCACATGGGCCACGGGCCTCCTAGGTGATTTTGATGCATGTGGCTCGCAGTCTCGAGAATGTGTTAAGGGGGTCTGGTGGA
CCCTCCTTGGGTTCAGGTGTCCCTACCTGCACCGGACGACGGGGGACACAGAACGCAAGTACCACCTGCGTTACTACAAAACAGGAACCT
GCATCCACGAGACAGACGCACGTGGCCACTGCGTGAAGAATGGGCTGCACTGTGCCTTCGCGCACGGCCCCCTGGACCTGCGGCCGCCCG
TGTGTGACGTCAGGGAGCTGCAGGCCCAGGAAGCCTTGCAGAACGGCCAGCTGGGCGGCGGGGAAGGGGTCCCGGATCTGCAGCCTGGGG
TCTTGGCCAGCCAGGCCATGATTGAGAAGATCCTGAGCGAGGACCCCCGGTGGCAAGCATTGCTTCCAGTCGCGCTGCTCAGGCACCGTG
TGGCCCATTTTTCAGATGCCAACTTCGTGCTGGGCAGCTACAAGACGGAGCAGTGCCCGAAGCCGCCACGCCTGTGCCGCCAGGGCTATG
CGTGCCCACACTACCACAATAGCCGGGACAGGCGGCGCAACCCCCGGCGGTTCCAGTACAGGTCCACGCCCTGCCCCAGTGTGAAGCACG
GGGATGAGTGGGGGGAACCCTCACGCTGCGATGGCGGCGACGGCTGCCAGTATTGCCACTCCCGCACGGAGCAGCAGTTCCATCCCGAGG
GGCCTGTCGGGAGTCCGGTGTCCGGGGCGTTTTCTGTGTTCAGTCACGCAGGCCTGGTTGCAGACCCCAGTCTCTGGTACCCAGCTGAGT
GGAGCTGGCACCACGTGGGCCACAGCCGCACCATAAATCCTGAGGGAGATAAACCCTCCCGCCTGGGCCCCGCCCCAGAAAATATCAAGC
GGGGAAATGACTTTGCCTGTGATGGGAGGGCAGATGCTGCGGGAATGGCCCCACATGTGTGCGTGTTCCCTATCTACAAATCTACAAAAT
GCAACGACATGCGCCAAACCGGGTACTGCCCGCGCGGCCCCTTCTGTGCCTTTGCACACGTTGAGAAGAGCCTGGGGATGGTGAATGAAT
GGGGCTGTCACGACCTCCACCTCACGAGTCCTTCCTCCACGGGCAGCGGCCAGCCGGGAAATGCCAAGCGGAGAGACTCGCCGGCCGAGG
GTGGCCCTAGGGGCAGCGAGCAAGACAGCAAGCAGGCGAAAGACAGTGATGATGAAGAGGAGGTGGTCCACGTGGATCGGGACCACTTCA
TGGATGAGTTCTTTGAACAGGTGGAAGAGATCCGGGGCTGCATTGAGAAACTGTCGGAGGATGTGGAGCAGGTGAAAAAACAGCATAGCG
CCATCCTGGCCGCACCCAACCCAGATGAGAAGACCAAACAGGAGCTGGAGGATCTCACTGCAGACATCAAGAAGACGGCCAACAAGGTTC
GGTCCAAATTGAAAGCGATCGAGCAAAGCATTGAACAGGAGGAGGGGCTGAACCGTTCCTCCGCGGACCTGCGCATCCGCAAGACCCAGC
ACTCCACACTGTCCCGGAAGTTCGTGGAGGTAATGACCGAATATAACGCGACCCAGTCCAAGTACCGGGACCGCTGCAAGGACCGGATCC
AGCGGCAACTGGAGATCACTGGAAGGACCACCACCAACGAAGAACTGGAAGACATGCTGGAGAGCGGGAAGCTGGCCATCTTCACAGATG
ACATCAAAATGGACTCACAGATGACGAAGCAGGCGCTGAATGAGATTGAGACGAGGCACAATGAGATCATCAAGCTGGAGACCAGCATCC
GCGAGCTGCACGATATGTTTGTGGACATGGCCATGCTCGTAGAGAGCCAGGGAGAGATGATTGACCGCATCGAGTACAACGTGGAACATT
CTGTGGACTACGTGGAGCGAGCTGTGTCTGACACCAAGAAAGCAGTGAAATATCAGAGCAAGGCCCGGAGGAAGAAAATCATGATCATCA
TTTGCTGTGTGGTGCTGGGGGTGGTCTTGGCGTCATCCATTGGGGGGACGCTGGGCTTGTAGGCCCCCCCCACCCTTCTCTCTCCCAGAC
CCTTCCCCCACCACATCGGGAGCAATACCCCCACCACCCCTTTCACTCCATCCCCTGCTCCAGGCTCACTCCCAAAACAGACCCAGGCAG
CCCCACCCCCACGGCAGACCCTGGTGTCCCTGGACCTCACCGGGCCATGGACCCCCCCCCCGTCCCCGCACGTAGATCGCAGCAGGCGTG
ATTACACATGCACACCAACATGCATGCCGCCGGCACATGCTCGAGACGTGTGGACACCCCAGCGTGCGTGTGCGTGTGATGTGTGTGATG
CACCAGAGCACCCCCTCCACCCCCACCTTGGGTGTGTGTGCGTGGTCTGAGCTTCCCCCTTCACCGGGGCTGTTGTGTAGACTGCAGCCA
AGTGTAACACAGCAGTCCATCACGCCCTCTCTGTCCTCTGTGAACAGTGTGTGTGCGTGCGTGAGACCACAGATCTGTGGACACACCATT
TGTGTACGTGGAATTTTGTGTTTCAGTGTTTGAACCTAATGCAACAGCAACAAAGCCACTGATACCTGAGCCCTTTGTGTCTGCTACAAA
CCAGGCAGGTGGTGTGTGTGGACTCACACTCACATTCTCAGAGGATCCAGGGAGGCCCAGGTACACACAGGCCATGGCAGACACCCCATG
TCTTTGTTACCCCAGGGGCTGTGGCATGTCCCAGGAGGGTGTGCATGTGTGTGTGTGTGTGTGTGTGTGTGTCCAGGATGTGCCTGAAGT
ATTGATAGGTCTTCTCAGATAGAGCCCTCCACACTGTGGACTGGACACCTGTTTTGGGAGGGCACAGAAATGTGTATTTCTTGCTACCTA
GAATGCAGCTGTGTGTGTGTGGCGTGCGTGTGTATGCACGTGTGTGTGTGTGTTAGGGGCTCTCTACATGGTGTGCTTTTTAATTTTTTT
TTGTTTTTTGTTTTTTGTTTTTTTCGAGACGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACC
TGTGCCTCCCTGACGCAAGCGATTCTCATGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCTGCCACCACGCCTGGCTAATTTTAG
AATTTTAGTAGAGATGAGGTTTTGACATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCCACTTTGGCCTCCCTAAG
TGCTGGCATTACAGGCCTGAGCCACCACGCCTGGCCTACATGATGTGTTTCTGTCCTGCCTGACCTACATGGTGTGTTTCTGCCCTGCGT
ATTACACACACACACACACACGTGCGTGCACACACACTTCTAAGGACGTGGCCCCATCTGGCTTTGTCTCTCCAGTTGTCCTTGCCCTGC
CCCCCTCCCCAGAGGTGCTGCCCAGTGCTGGTGTGGCCACACACGGCTACATCATTGTGCAGGCAGAGCTCCCTGCCTGCCCAGCCTCAG
GGCTCTGCATGCTCACACCTAGATCCTCATCTTCCTCCATGTCTCTGCCCAGCATAGCCCCGAGCCCCTGGAAGCTGGTACCCCTCAGTG
TGCTCACACGTGGCAAGGCCGAGGTGGCCCCAGGCAGGGGCCATACCAGGCACAAACCATGCACGCTGGCATGGGTGCGGGGATCACACG
AATGCCTCCTGGAAGGAAAGGGCTACTTGTAGGAATGTTACTGATGAGGCAAGATGCCAAGGACTTCCCTGCAGGGATCAAAGATCAGGA
CACGACCCCTTCCTCACACACCCACCTCAGACCTGGGAGAGGACTGTGTGTCCCCCACTGCCCCATCGGATGCTCTGGGCTCTGCCTCAG
GGAACTCGGGTTTGGGGAAATGTCTATTTCAGAAGTACTGGAGTGGCCAGTGTGGCAGTGGCCACTCAGGGTGGGCTGGGTCCTGAGACC
CATCCCCGACACCTCTCCTGCTGAACCCTCAGGCTGCTCCCCACACCAGGGTGTGACTGAGGGGTACACAGGCCTGGATTTCTGGTGTGA
GGAAGGGGCTAGCACCTCCCCTGTTGTGTAGCCAGCACAGGCACAATTTGTGGGTTTGGTGGCAGGTAGGTGGTGCGTGGGAGAAAGGAC
AGTGTTAGAGGTCCCCACTCCGTGGTCTAGGATCATGAAAGGTGAACACACAAGTACACAAATGTGCCATGCCCTGGCATGGGGCTTATG
TGTGCACAGGCAAGGCACTCGGTGTGTGTGTGCGGACCCCAGGGTCCCAGGTCATGTGAAGCGTACGTGTGTGTGCATTGTATGTGTGTG
TACATTGTGTGTGCATTGTGTGTGCATGTGGCCAAACAGATGTGACCTCCCAGAACACAGTACCCCTCCACCTCTACCCGAGCTCAGACA
GCCGAGCTCTCCCTTGTCCTGTGTGTGTGTCAGTGTGGCCACGTGCGTAACCCCAGGTGGGCTGTCCTGAGCTGGGGGCCTGCCTGTCCC
TTCCCAGAACGCCCCTCTGCAGGACAGGAAGTCTGCCCCAAGTCTGGCCACGGCCCTCCTGCTCCCATCTCGGGCTGCTTGGGAGACATC
AGAGCAGGCCCCAGCCCCCAGTCCCCTCTTCCGGCCGCCTGGACAGGACCCCCATTCAGCCCAGGTGTTTCCGGAAGTCCCACGGCCTTG
GGGCCACAGGAGAAGGGTTGAAGCGTGGCTGGGGCACCACTCCCCCCACCTGGAGTGGCATTGGGCCCACAGCTGCCCATCTCTGGGCCT
CAGGTGGACCAGGGGATCTCTAAGGGTCTGCTGTGCCCTTTCTATGCGTCCTCCACATCCTATGATGTGCCTGCTTGTTGGCTGCTGTCT
GTGTGCGTCCTGGCATGTTGTCTGGAGGCTGGTGTCTTTTGCATGTTCTTGGACAAATGTGTGCTACCTGCCCAGGCGCCTGCAACCATT
GAGCCCACATGTGCCCCACGTGTGCCCTGCGGGTGGTCCCGGGCCTGGCCAGGGCTCAGTGCTCCTCTTCCCCCTCCTCCCTGTTCCCAC
CCCTCATGAAGCACACTGCGTGTCCATCCCATGTACCCGTGGGTCGACACACGCTCTTGCCACGCCCTGAGCGTGTACACATGATGTGTT
CTATGCATTCACCCTGCCCCCCAGCCCGCCCTGCAGAGGACAAGATGGGTGGCCCCGGCTCCCTTTCCCCTAACCGCCCCTGCCCGCTGT
GCAGCCGTGTGCGTTGGCGTGTGTTTCTGTGTCACTGGCGTGTCACGTGATGTAGCCGTGTTTGCTGACATGAGCCCCTGCCCCCTTCTC
TGTTTCTCCGTTGGTTTCTAGAGCTCTCTCCCTCCCCTTCTCAGAGGGGACAGGACTCCTGGGGCCTGGCTGGGGCCCAGAGCCAGGCCG
CCCTCTCCTGTTAGCCCTCAGAGTCCCATTTCTGTTAGCCCTCAGAGTCCCATTTCTATTGGTGACCAACTTGCAAATGGATAAAACACA
GGAAAATCCTGCCCCCCCCTTCCTCCCTGCATGTCCTGTCCCCAGAGCCCCCCACCCCACCCTGGGCCAGGTCAGGCCCTGTGGGACGGG

>96892_96892_3_UNKL-STX1B_UNKL_chr16_1440633_ENST00000397462_STX1B_chr16_31012924_ENST00000215095_length(amino acids)=829AA_BP=550
LKMPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEAT
GVCPDGDESLLGVLYPLWAPPPVPAPVGAPTVHPFLARWFSHVPWEPAGSADPRASSTPAGGTTWATGLLGDFDACGSQSRECVKGVWWT
LLGFRCPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPGV
LASQAMIEKILSEDPRWQALLPVALLRHRVAHFSDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHG
DEWGEPSRCDGGDGCQYCHSRTEQQFHPEGPVGSPVSGAFSVFSHAGLVADPSLWYPAEWSWHHVGHSRTINPEGDKPSRLGPAPENIKR
GNDFACDGRADAAGMAPHVCVFPIYKSTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEG
GPRGSEQDSKQAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVR
SKLKAIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDD
IKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIII

--------------------------------------------------------------
>96892_96892_4_UNKL-STX1B_UNKL_chr16_1440633_ENST00000397462_STX1B_chr16_31012924_ENST00000565419_length(transcript)=2833nt_BP=1655nt
GACTGAAAATGCCGTCGGTTTCGAAAGCGGCGGCAGCGGCGCTGAGCGGGTCCCCCCCGCAGACTGAGAAGCCGACCCACTACAGGTACC
TGAAGGAGTTCAGGACGGAGCAGTGCCCCCTGTTTTCACAGCACAAGTGCGCGCAGCACCGGCCGTTCACCTGCTTCCACTGGCACTTCC
TCAACCAGCGGCGCCGCAGGCCCCTCCGCAGGCGCGACGGCACCTTCAACTACAGCCCCGACGTGTACTGCTCCAAGTACAACGAAGCCA
CCGGCGTGTGCCCCGACGGCGACGAGTCACTTCTCGGCGTCCTCTATCCTCTGTGGGCACCCCCTCCGGTGCCTGCCCCCGTGGGTGCCC
CCACTGTGCACCCTTTCCTAGCCCGGTGGTTCTCGCACGTTCCCTGGGAACCAGCCGGCAGTGCAGATCCACGGGCCTCGTCCACACCAG
CTGGGGGGACCACATGGGCCACGGGCCTCCTAGGTGATTTTGATGCATGTGGCTCGCAGTCTCGAGAATGTGTTAAGGGGGTCTGGTGGA
CCCTCCTTGGGTTCAGGTGTCCCTACCTGCACCGGACGACGGGGGACACAGAACGCAAGTACCACCTGCGTTACTACAAAACAGGAACCT
GCATCCACGAGACAGACGCACGTGGCCACTGCGTGAAGAATGGGCTGCACTGTGCCTTCGCGCACGGCCCCCTGGACCTGCGGCCGCCCG
TGTGTGACGTCAGGGAGCTGCAGGCCCAGGAAGCCTTGCAGAACGGCCAGCTGGGCGGCGGGGAAGGGGTCCCGGATCTGCAGCCTGGGG
TCTTGGCCAGCCAGGCCATGATTGAGAAGATCCTGAGCGAGGACCCCCGGTGGCAAGCATTGCTTCCAGTCGCGCTGCTCAGGCACCGTG
TGGCCCATTTTTCAGATGCCAACTTCGTGCTGGGCAGCTACAAGACGGAGCAGTGCCCGAAGCCGCCACGCCTGTGCCGCCAGGGCTATG
CGTGCCCACACTACCACAATAGCCGGGACAGGCGGCGCAACCCCCGGCGGTTCCAGTACAGGTCCACGCCCTGCCCCAGTGTGAAGCACG
GGGATGAGTGGGGGGAACCCTCACGCTGCGATGGCGGCGACGGCTGCCAGTATTGCCACTCCCGCACGGAGCAGCAGTTCCATCCCGAGG
GGCCTGTCGGGAGTCCGGTGTCCGGGGCGTTTTCTGTGTTCAGTCACGCAGGCCTGGTTGCAGACCCCAGTCTCTGGTACCCAGCTGAGT
GGAGCTGGCACCACGTGGGCCACAGCCGCACCATAAATCCTGAGGGAGATAAACCCTCCCGCCTGGGCCCCGCCCCAGAAAATATCAAGC
GGGGAAATGACTTTGCCTGTGATGGGAGGGCAGATGCTGCGGGAATGGCCCCACATGTGTGCGTGTTCCCTATCTACAAATCTACAAAAT
GCAACGACATGCGCCAAACCGGGTACTGCCCGCGCGGCCCCTTCTGTGCCTTTGCACACGTTGAGAAGAGCCTGGGGATGGTGAATGAAT
GGGGCTGTCACGACCTCCACCTCACGAGTCCTTCCTCCACGGGCAGCGGCCAGCCGGGAAATGCCAAGCGGAGAGACTCGCCGGCCGAGG
GTGGCCCTAGGGGCAGCGAGCAAGACAGCAAGCAGGCGAAAGACAGTGATGATGAAGAGGAGGTGGTCCACGTGGATCGGGACCACTTCA
TGGATGAGTTCTTTGAACAGGTGGAAGAGATCCGGGGCTGCATTGAGAAACTGTCGGAGGATGTGGAGCAGGTGAAAAAACAGCATAGCG
CCATCCTGGCCGCACCCAACCCAGATGAGAAGACCAAACAGGAGCTGGAGGATCTCACTGCAGACATCAAGAAGACGGCCAACAAGGTTC
GGTCCAAATTGAAAGCGATCGAGCAAAGCATTGAACAGGAGGAGGGGCTGAACCGTTCCTCCGCGGACCTGCGCATCCGCAAGACCCAGC
ACTCCACACTGTCCCGGAAGTTCGTGGAGGTAATGACCGAATATAACGCGACCCAGTCCAAGTACCGGGACCGCTGCAAGGACCGGATCC
AGCGGCAACTGGAGATCACTGGAAGGACCACCACCAACGAAGAACTGGAAGACATGCTGGAGAGCGGGAAGCTGGCCATCTTCACAGATG
ACATCAAAATGGACTCACAGATGACGAAGCAGGCGCTGAATGAGATTGAGACGAGGCACAATGAGATCATCAAGCTGGAGACCAGCATCC
GCGAGCTGCACGATATGTTTGTGGACATGGCCATGCTCGTAGAGAGCCAGGGAGAGATGATTGACCGCATCGAGTACAACGTGGAACATT
CTGTGGACTACGTGGAGCGAGCTGTGTCTGACACCAAGAAAGCAGTGAAATATCAGAGCAAGGCCCGGAGGGTGAGCGGGGCAGGCGGCC
TGGGGGTAGGCGGGGGAGCCCAAGGCTGAGCCCGGGCTGAGGTGAGTGATGGCAGCGGGCGGGAGGCCTTATCTCTGGCTCTGACCTCTT
CCTGTTTCTGTTTTCTCTCCCCTCTTCTCCCTGCCACCCTCTGCCCTGTCTGTCCCTGCATCTGTCCGTGTGTCGATCTCTCTCACTGTC
TGCCTGTCTCACTCCTCTTTCTGCTGCAGAAGAAAATCATGATCATCATTTGCTGTGTGGTGCTGGGGGTGGTCTTGGCGTCATCCATTG
GGGGGACGCTGGGCTTGTAGGCCCCCCCCACCCTTCTCTCTCCCAGACCCTTCCCCCACCACATCGGGAGCAATACCCCCACCACCCCTT

>96892_96892_4_UNKL-STX1B_UNKL_chr16_1440633_ENST00000397462_STX1B_chr16_31012924_ENST00000565419_length(amino acids)=818AA_BP=550
LKMPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEAT
GVCPDGDESLLGVLYPLWAPPPVPAPVGAPTVHPFLARWFSHVPWEPAGSADPRASSTPAGGTTWATGLLGDFDACGSQSRECVKGVWWT
LLGFRCPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPGV
LASQAMIEKILSEDPRWQALLPVALLRHRVAHFSDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHG
DEWGEPSRCDGGDGCQYCHSRTEQQFHPEGPVGSPVSGAFSVFSHAGLVADPSLWYPAEWSWHHVGHSRTINPEGDKPSRLGPAPENIKR
GNDFACDGRADAAGMAPHVCVFPIYKSTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEG
GPRGSEQDSKQAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVR
SKLKAIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDD
IKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRVSGAGGL

--------------------------------------------------------------
>96892_96892_5_UNKL-STX1B_UNKL_chr16_1440633_ENST00000508903_STX1B_chr16_31012924_ENST00000215095_length(transcript)=5488nt_BP=1086nt
ATGCCGTCGGTTTCGAAAGCGGCGGCAGCGGCGCTGAGCGGGTCCCCCCCGCAGACTGAGAAGCCGACCCACTACAGGTACCTGAAGGAG
TTCAGGACGGAGCAGTGCCCCCTGTTTTCACAGCACAAGTGCGCGCAGCACCGGCCGTTCACCTGCTTCCACTGGCACTTCCTCAACCAG
CGGCGCCGCAGGCCCCTCCGCAGGCGCGACGGCACCTTCAACTACAGCCCCGACGTGTACTGCTCCAAGTACAACGAAGCCACCGGCGTG
TGCCCCGACGGCGACGAGTGTCCCTACCTGCACCGGACGACGGGGGACACAGAACGCAAGTACCACCTGCGTTACTACAAAACAGGAACC
TGCATCCACGAGACAGACGCACGTGGCCACTGCGTGAAGAATGGGCTGCACTGTGCCTTCGCGCACGGCCCCCTGGACCTGCGGCCGCCC
GTGTGTGACGTCAGGGAGCTGCAGGCCCAGGAAGCCTTGCAGAACGGCCAGCTGGGCGGCGGGGAAGGGGTCCCGGATCTGCAGCCTGGG
GTCTTGGCCAGCCAGGCCATGATTGAGAAGATCCTGAGCGAGGACCCCCGGTGGCAAGATGCCAACTTCGTGCTGGGCAGCTACAAGACG
GAGCAGTGCCCGAAGCCGCCACGCCTGTGCCGCCAGGGCTATGCGTGCCCACACTACCACAATAGCCGGGACAGGCGGCGCAACCCCCGG
CGGTTCCAGTACAGGTCCACGCCCTGCCCCAGTGTGAAGCACGGGGATGAGTGGGGGGAACCCTCACGCTGCGATGGCGGCGACGGCTGC
CAGTATTGCCACTCCCGCACGGAGCAGCAGTTCCATCCCGAGATCTACAAATCTACAAAATGCAACGACATGCGCCAAACCGGGTACTGC
CCGCGCGGCCCCTTCTGTGCCTTTGCACACGTTGAGAAGAGCCTGGGGATGGTGAATGAATGGGGCTGTCACGACCTCCACCTCACGAGT
CCTTCCTCCACGGGCAGCGGCCAGCCGGGAAATGCCAAGCGGAGAGACTCGCCGGCCGAGGGTGGCCCTAGGGGCAGCGAGCAAGACAGC
AAGCAGGCGAAAGACAGTGATGATGAAGAGGAGGTGGTCCACGTGGATCGGGACCACTTCATGGATGAGTTCTTTGAACAGGTGGAAGAG
ATCCGGGGCTGCATTGAGAAACTGTCGGAGGATGTGGAGCAGGTGAAAAAACAGCATAGCGCCATCCTGGCCGCACCCAACCCAGATGAG
AAGACCAAACAGGAGCTGGAGGATCTCACTGCAGACATCAAGAAGACGGCCAACAAGGTTCGGTCCAAATTGAAAGCGATCGAGCAAAGC
ATTGAACAGGAGGAGGGGCTGAACCGTTCCTCCGCGGACCTGCGCATCCGCAAGACCCAGCACTCCACACTGTCCCGGAAGTTCGTGGAG
GTAATGACCGAATATAACGCGACCCAGTCCAAGTACCGGGACCGCTGCAAGGACCGGATCCAGCGGCAACTGGAGATCACTGGAAGGACC
ACCACCAACGAAGAACTGGAAGACATGCTGGAGAGCGGGAAGCTGGCCATCTTCACAGATGACATCAAAATGGACTCACAGATGACGAAG
CAGGCGCTGAATGAGATTGAGACGAGGCACAATGAGATCATCAAGCTGGAGACCAGCATCCGCGAGCTGCACGATATGTTTGTGGACATG
GCCATGCTCGTAGAGAGCCAGGGAGAGATGATTGACCGCATCGAGTACAACGTGGAACATTCTGTGGACTACGTGGAGCGAGCTGTGTCT
GACACCAAGAAAGCAGTGAAATATCAGAGCAAGGCCCGGAGGAAGAAAATCATGATCATCATTTGCTGTGTGGTGCTGGGGGTGGTCTTG
GCGTCATCCATTGGGGGGACGCTGGGCTTGTAGGCCCCCCCCACCCTTCTCTCTCCCAGACCCTTCCCCCACCACATCGGGAGCAATACC
CCCACCACCCCTTTCACTCCATCCCCTGCTCCAGGCTCACTCCCAAAACAGACCCAGGCAGCCCCACCCCCACGGCAGACCCTGGTGTCC
CTGGACCTCACCGGGCCATGGACCCCCCCCCCGTCCCCGCACGTAGATCGCAGCAGGCGTGATTACACATGCACACCAACATGCATGCCG
CCGGCACATGCTCGAGACGTGTGGACACCCCAGCGTGCGTGTGCGTGTGATGTGTGTGATGCACCAGAGCACCCCCTCCACCCCCACCTT
GGGTGTGTGTGCGTGGTCTGAGCTTCCCCCTTCACCGGGGCTGTTGTGTAGACTGCAGCCAAGTGTAACACAGCAGTCCATCACGCCCTC
TCTGTCCTCTGTGAACAGTGTGTGTGCGTGCGTGAGACCACAGATCTGTGGACACACCATTTGTGTACGTGGAATTTTGTGTTTCAGTGT
TTGAACCTAATGCAACAGCAACAAAGCCACTGATACCTGAGCCCTTTGTGTCTGCTACAAACCAGGCAGGTGGTGTGTGTGGACTCACAC
TCACATTCTCAGAGGATCCAGGGAGGCCCAGGTACACACAGGCCATGGCAGACACCCCATGTCTTTGTTACCCCAGGGGCTGTGGCATGT
CCCAGGAGGGTGTGCATGTGTGTGTGTGTGTGTGTGTGTGTGTCCAGGATGTGCCTGAAGTATTGATAGGTCTTCTCAGATAGAGCCCTC
CACACTGTGGACTGGACACCTGTTTTGGGAGGGCACAGAAATGTGTATTTCTTGCTACCTAGAATGCAGCTGTGTGTGTGTGGCGTGCGT
GTGTATGCACGTGTGTGTGTGTGTTAGGGGCTCTCTACATGGTGTGCTTTTTAATTTTTTTTTGTTTTTTGTTTTTTGTTTTTTTCGAGA
CGGAGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTGTGCCTCCCTGACGCAAGCGATTCTCAT
GCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCCTGCCACCACGCCTGGCTAATTTTAGAATTTTAGTAGAGATGAGGTTTTGACATG
TTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCCACTTTGGCCTCCCTAAGTGCTGGCATTACAGGCCTGAGCCACCACG
CCTGGCCTACATGATGTGTTTCTGTCCTGCCTGACCTACATGGTGTGTTTCTGCCCTGCGTATTACACACACACACACACACGTGCGTGC
ACACACACTTCTAAGGACGTGGCCCCATCTGGCTTTGTCTCTCCAGTTGTCCTTGCCCTGCCCCCCTCCCCAGAGGTGCTGCCCAGTGCT
GGTGTGGCCACACACGGCTACATCATTGTGCAGGCAGAGCTCCCTGCCTGCCCAGCCTCAGGGCTCTGCATGCTCACACCTAGATCCTCA
TCTTCCTCCATGTCTCTGCCCAGCATAGCCCCGAGCCCCTGGAAGCTGGTACCCCTCAGTGTGCTCACACGTGGCAAGGCCGAGGTGGCC
CCAGGCAGGGGCCATACCAGGCACAAACCATGCACGCTGGCATGGGTGCGGGGATCACACGAATGCCTCCTGGAAGGAAAGGGCTACTTG
TAGGAATGTTACTGATGAGGCAAGATGCCAAGGACTTCCCTGCAGGGATCAAAGATCAGGACACGACCCCTTCCTCACACACCCACCTCA
GACCTGGGAGAGGACTGTGTGTCCCCCACTGCCCCATCGGATGCTCTGGGCTCTGCCTCAGGGAACTCGGGTTTGGGGAAATGTCTATTT
CAGAAGTACTGGAGTGGCCAGTGTGGCAGTGGCCACTCAGGGTGGGCTGGGTCCTGAGACCCATCCCCGACACCTCTCCTGCTGAACCCT
CAGGCTGCTCCCCACACCAGGGTGTGACTGAGGGGTACACAGGCCTGGATTTCTGGTGTGAGGAAGGGGCTAGCACCTCCCCTGTTGTGT
AGCCAGCACAGGCACAATTTGTGGGTTTGGTGGCAGGTAGGTGGTGCGTGGGAGAAAGGACAGTGTTAGAGGTCCCCACTCCGTGGTCTA
GGATCATGAAAGGTGAACACACAAGTACACAAATGTGCCATGCCCTGGCATGGGGCTTATGTGTGCACAGGCAAGGCACTCGGTGTGTGT
GTGCGGACCCCAGGGTCCCAGGTCATGTGAAGCGTACGTGTGTGTGCATTGTATGTGTGTGTACATTGTGTGTGCATTGTGTGTGCATGT
GGCCAAACAGATGTGACCTCCCAGAACACAGTACCCCTCCACCTCTACCCGAGCTCAGACAGCCGAGCTCTCCCTTGTCCTGTGTGTGTG
TCAGTGTGGCCACGTGCGTAACCCCAGGTGGGCTGTCCTGAGCTGGGGGCCTGCCTGTCCCTTCCCAGAACGCCCCTCTGCAGGACAGGA
AGTCTGCCCCAAGTCTGGCCACGGCCCTCCTGCTCCCATCTCGGGCTGCTTGGGAGACATCAGAGCAGGCCCCAGCCCCCAGTCCCCTCT
TCCGGCCGCCTGGACAGGACCCCCATTCAGCCCAGGTGTTTCCGGAAGTCCCACGGCCTTGGGGCCACAGGAGAAGGGTTGAAGCGTGGC
TGGGGCACCACTCCCCCCACCTGGAGTGGCATTGGGCCCACAGCTGCCCATCTCTGGGCCTCAGGTGGACCAGGGGATCTCTAAGGGTCT
GCTGTGCCCTTTCTATGCGTCCTCCACATCCTATGATGTGCCTGCTTGTTGGCTGCTGTCTGTGTGCGTCCTGGCATGTTGTCTGGAGGC
TGGTGTCTTTTGCATGTTCTTGGACAAATGTGTGCTACCTGCCCAGGCGCCTGCAACCATTGAGCCCACATGTGCCCCACGTGTGCCCTG
CGGGTGGTCCCGGGCCTGGCCAGGGCTCAGTGCTCCTCTTCCCCCTCCTCCCTGTTCCCACCCCTCATGAAGCACACTGCGTGTCCATCC
CATGTACCCGTGGGTCGACACACGCTCTTGCCACGCCCTGAGCGTGTACACATGATGTGTTCTATGCATTCACCCTGCCCCCCAGCCCGC
CCTGCAGAGGACAAGATGGGTGGCCCCGGCTCCCTTTCCCCTAACCGCCCCTGCCCGCTGTGCAGCCGTGTGCGTTGGCGTGTGTTTCTG
TGTCACTGGCGTGTCACGTGATGTAGCCGTGTTTGCTGACATGAGCCCCTGCCCCCTTCTCTGTTTCTCCGTTGGTTTCTAGAGCTCTCT
CCCTCCCCTTCTCAGAGGGGACAGGACTCCTGGGGCCTGGCTGGGGCCCAGAGCCAGGCCGCCCTCTCCTGTTAGCCCTCAGAGTCCCAT
TTCTGTTAGCCCTCAGAGTCCCATTTCTATTGGTGACCAACTTGCAAATGGATAAAACACAGGAAAATCCTGCCCCCCCCTTCCTCCCTG

>96892_96892_5_UNKL-STX1B_UNKL_chr16_1440633_ENST00000508903_STX1B_chr16_31012924_ENST00000215095_length(amino acids)=640AA_BP=361
MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEATGV
CPDGDECPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPG
VLASQAMIEKILSEDPRWQDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGC
QYCHSRTEQQFHPEIYKSTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEGGPRGSEQDS
KQAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQS
IEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTK
QALNEIETRHNEIIKLETSIRELHDMFVDMAMLVESQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVL

--------------------------------------------------------------
>96892_96892_6_UNKL-STX1B_UNKL_chr16_1440633_ENST00000508903_STX1B_chr16_31012924_ENST00000565419_length(transcript)=2264nt_BP=1086nt
ATGCCGTCGGTTTCGAAAGCGGCGGCAGCGGCGCTGAGCGGGTCCCCCCCGCAGACTGAGAAGCCGACCCACTACAGGTACCTGAAGGAG
TTCAGGACGGAGCAGTGCCCCCTGTTTTCACAGCACAAGTGCGCGCAGCACCGGCCGTTCACCTGCTTCCACTGGCACTTCCTCAACCAG
CGGCGCCGCAGGCCCCTCCGCAGGCGCGACGGCACCTTCAACTACAGCCCCGACGTGTACTGCTCCAAGTACAACGAAGCCACCGGCGTG
TGCCCCGACGGCGACGAGTGTCCCTACCTGCACCGGACGACGGGGGACACAGAACGCAAGTACCACCTGCGTTACTACAAAACAGGAACC
TGCATCCACGAGACAGACGCACGTGGCCACTGCGTGAAGAATGGGCTGCACTGTGCCTTCGCGCACGGCCCCCTGGACCTGCGGCCGCCC
GTGTGTGACGTCAGGGAGCTGCAGGCCCAGGAAGCCTTGCAGAACGGCCAGCTGGGCGGCGGGGAAGGGGTCCCGGATCTGCAGCCTGGG
GTCTTGGCCAGCCAGGCCATGATTGAGAAGATCCTGAGCGAGGACCCCCGGTGGCAAGATGCCAACTTCGTGCTGGGCAGCTACAAGACG
GAGCAGTGCCCGAAGCCGCCACGCCTGTGCCGCCAGGGCTATGCGTGCCCACACTACCACAATAGCCGGGACAGGCGGCGCAACCCCCGG
CGGTTCCAGTACAGGTCCACGCCCTGCCCCAGTGTGAAGCACGGGGATGAGTGGGGGGAACCCTCACGCTGCGATGGCGGCGACGGCTGC
CAGTATTGCCACTCCCGCACGGAGCAGCAGTTCCATCCCGAGATCTACAAATCTACAAAATGCAACGACATGCGCCAAACCGGGTACTGC
CCGCGCGGCCCCTTCTGTGCCTTTGCACACGTTGAGAAGAGCCTGGGGATGGTGAATGAATGGGGCTGTCACGACCTCCACCTCACGAGT
CCTTCCTCCACGGGCAGCGGCCAGCCGGGAAATGCCAAGCGGAGAGACTCGCCGGCCGAGGGTGGCCCTAGGGGCAGCGAGCAAGACAGC
AAGCAGGCGAAAGACAGTGATGATGAAGAGGAGGTGGTCCACGTGGATCGGGACCACTTCATGGATGAGTTCTTTGAACAGGTGGAAGAG
ATCCGGGGCTGCATTGAGAAACTGTCGGAGGATGTGGAGCAGGTGAAAAAACAGCATAGCGCCATCCTGGCCGCACCCAACCCAGATGAG
AAGACCAAACAGGAGCTGGAGGATCTCACTGCAGACATCAAGAAGACGGCCAACAAGGTTCGGTCCAAATTGAAAGCGATCGAGCAAAGC
ATTGAACAGGAGGAGGGGCTGAACCGTTCCTCCGCGGACCTGCGCATCCGCAAGACCCAGCACTCCACACTGTCCCGGAAGTTCGTGGAG
GTAATGACCGAATATAACGCGACCCAGTCCAAGTACCGGGACCGCTGCAAGGACCGGATCCAGCGGCAACTGGAGATCACTGGAAGGACC
ACCACCAACGAAGAACTGGAAGACATGCTGGAGAGCGGGAAGCTGGCCATCTTCACAGATGACATCAAAATGGACTCACAGATGACGAAG
CAGGCGCTGAATGAGATTGAGACGAGGCACAATGAGATCATCAAGCTGGAGACCAGCATCCGCGAGCTGCACGATATGTTTGTGGACATG
GCCATGCTCGTAGAGAGCCAGGGAGAGATGATTGACCGCATCGAGTACAACGTGGAACATTCTGTGGACTACGTGGAGCGAGCTGTGTCT
GACACCAAGAAAGCAGTGAAATATCAGAGCAAGGCCCGGAGGGTGAGCGGGGCAGGCGGCCTGGGGGTAGGCGGGGGAGCCCAAGGCTGA
GCCCGGGCTGAGGTGAGTGATGGCAGCGGGCGGGAGGCCTTATCTCTGGCTCTGACCTCTTCCTGTTTCTGTTTTCTCTCCCCTCTTCTC
CCTGCCACCCTCTGCCCTGTCTGTCCCTGCATCTGTCCGTGTGTCGATCTCTCTCACTGTCTGCCTGTCTCACTCCTCTTTCTGCTGCAG
AAGAAAATCATGATCATCATTTGCTGTGTGGTGCTGGGGGTGGTCTTGGCGTCATCCATTGGGGGGACGCTGGGCTTGTAGGCCCCCCCC
ACCCTTCTCTCTCCCAGACCCTTCCCCCACCACATCGGGAGCAATACCCCCACCACCCCTTTCACTCCATCCCCTGCTCCAGGCTCACTC

>96892_96892_6_UNKL-STX1B_UNKL_chr16_1440633_ENST00000508903_STX1B_chr16_31012924_ENST00000565419_length(amino acids)=629AA_BP=361
MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEATGV
CPDGDECPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPG
VLASQAMIEKILSEDPRWQDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGC
QYCHSRTEQQFHPEIYKSTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEGGPRGSEQDS
KQAKDSDDEEEVVHVDRDHFMDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLKAIEQS
IEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRTTTNEELEDMLESGKLAIFTDDIKMDSQMTK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for UNKL-STX1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UNKL-STX1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UNKL-STX1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource