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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UQCC1-DYNLRB1 (FusionGDB2 ID:96949)

Fusion Gene Summary for UQCC1-DYNLRB1

check button Fusion gene summary
Fusion gene informationFusion gene name: UQCC1-DYNLRB1
Fusion gene ID: 96949
HgeneTgene
Gene symbol

UQCC1

DYNLRB1

Gene ID

55245

83658

Gene nameubiquinol-cytochrome c reductase complex assembly factor 1dynein light chain roadblock-type 1
SynonymsBFZB|C20orf44|CBP3|UQCCBITH|BLP|DNCL2A|DNLC2A|ROBLD1
Cytomap

20q11.22

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionubiquinol-cytochrome-c reductase complex assembly factor 1bFGF-repressed Zic-binding proteinbasic FGF-repressed Zic-binding proteincytochrome B protein synthesis 3 homologubiquinol-cytochrome c reductase complex chaperone CBP3 homologdynein light chain roadblock-type 1ROBL/LC7-like 1bithoraxoid-like proteindynein, cytoplasmic, light polypeptide 2Adynein-associated protein Km23roadblock domain-containing protein 1
Modification date2020031320200320
UniProtAcc.

Q9NP97

Ensembl transtripts involved in fusion geneENST00000349714, ENST00000374377, 
ENST00000374380, ENST00000374384, 
ENST00000374385, ENST00000397556, 
ENST00000540457, ENST00000542501, 
ENST00000491125, ENST00000359226, 
ENST00000397554, ENST00000407996, 
ENST00000300469, ENST00000374846, 
ENST00000417166, ENST00000480759, 
ENST00000357156, 
Fusion gene scores* DoF score20 X 11 X 12=264017 X 12 X 12=2448
# samples 2023
** MAII scorelog2(20/2640*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2448*10)=-3.41189779174828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UQCC1 [Title/Abstract] AND DYNLRB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUQCC1(33934967)-DYNLRB1(33114073), # samples:1
Anticipated loss of major functional domain due to fusion event.UQCC1-DYNLRB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
UQCC1-DYNLRB1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUQCC1

GO:0034551

mitochondrial respiratory chain complex III assembly

24385928

HgeneUQCC1

GO:0070131

positive regulation of mitochondrial translation

24385928


check buttonFusion gene breakpoints across UQCC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DYNLRB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PD-01AUQCC1chr20

33934967

-DYNLRB1chr20

33114073

+


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Fusion Gene ORF analysis for UQCC1-DYNLRB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000349714ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000349714ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000349714ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000349714ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374377ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374377ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374377ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374377ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374380ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374380ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374380ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374380ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374384ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374384ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374384ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374384ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374385ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374385ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374385ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000374385ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000397556ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000397556ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000397556ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000397556ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000540457ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000540457ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000540457ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000540457ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000542501ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000542501ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000542501ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5CDS-3UTRENST00000542501ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5UTR-3CDSENST00000491125ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000491125ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000491125ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000491125ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
5UTR-3UTRENST00000491125ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
Frame-shiftENST00000374377ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
Frame-shiftENST00000540457ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
In-frameENST00000349714ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
In-frameENST00000374380ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
In-frameENST00000374384ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
In-frameENST00000374385ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
In-frameENST00000397556ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
In-frameENST00000542501ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3CDSENST00000359226ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3CDSENST00000397554ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3CDSENST00000407996ENST00000357156UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000359226ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000359226ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000359226ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000359226ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000397554ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000397554ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000397554ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000397554ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000407996ENST00000300469UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000407996ENST00000374846UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000407996ENST00000417166UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+
intron-3UTRENST00000407996ENST00000480759UQCC1chr20

33934967

-DYNLRB1chr20

33114073

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000349714UQCC1chr2033934967-ENST00000357156DYNLRB1chr2033114073+11144920779259
ENST00000374384UQCC1chr2033934967-ENST00000357156DYNLRB1chr2033114073+12055831870289
ENST00000374380UQCC1chr2033934967-ENST00000357156DYNLRB1chr2033114073+105943759724221
ENST00000374385UQCC1chr2033934967-ENST00000357156DYNLRB1chr2033114073+13737511691038289
ENST00000397556UQCC1chr2033934967-ENST00000357156DYNLRB1chr2033114073+105042820715231
ENST00000542501UQCC1chr2033934967-ENST00000357156DYNLRB1chr2033114073+10744521624207

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000349714ENST00000357156UQCC1chr2033934967-DYNLRB1chr2033114073+0.0266135690.9733864
ENST00000374384ENST00000357156UQCC1chr2033934967-DYNLRB1chr2033114073+0.0103038070.98969626
ENST00000374380ENST00000357156UQCC1chr2033934967-DYNLRB1chr2033114073+0.0101984650.9898016
ENST00000374385ENST00000357156UQCC1chr2033934967-DYNLRB1chr2033114073+0.0093256610.9906743
ENST00000397556ENST00000357156UQCC1chr2033934967-DYNLRB1chr2033114073+0.0295219740.970478
ENST00000542501ENST00000357156UQCC1chr2033934967-DYNLRB1chr2033114073+0.389942020.61005795

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Fusion Genomic Features for UQCC1-DYNLRB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
UQCC1chr2033934966-DYNLRB1chr2033114072+1.48E-050.9999852
UQCC1chr2033934966-DYNLRB1chr2033114072+1.48E-050.9999852

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for UQCC1-DYNLRB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:33934967/chr20:33114073)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DYNLRB1

Q9NP97

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for UQCC1-DYNLRB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96949_96949_1_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000349714_DYNLRB1_chr20_33114073_ENST00000357156_length(transcript)=1114nt_BP=492nt
ATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGTGTCTCCTACC
CAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGTGGCCCCAGATGAGCCAGTCCCGAGCATGTGGTGGATCAGAACAGATTCCT
GGAATAGACATACAGCTGAATAGGAAGTATCACACCACACGTAAGCTTTCTACTACCAAAGATTCCCCACAGCCTGTTGAGGAGAAGGTT
GGTGCTTTCACAAAGATAATAGAAGCCATGGGATTCACGGGACCTTTGAAATACAGGTGTCAGATGCCTGATACATTCAATTCATGGTTT
CTTATAACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCAT
TTTATGTGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGCAGAGGTGGAGGAGACACTGAAGCGACTGCAGAGCCAGAAGGGAGTG
CAGGGAATCATCGTCGTGAACACAGAAGGCATTCCCATCAAGAGCACCATGGACAACCCCACCACCACCCAGTATGCCAGCCTCATGCAC
AGCTTCATCCTGAAGGCACGGAGCACCGTGCGTGACATCGACCCCCAGAACGATCTCACCTTCCTTCGAATTCGCTCCAAGAAAAATGAA
ATTATGGTTGCACCAGATAAAGACTATTTCCTGATTGTGATTCAGAATCCAACCGAATAAGCCACTCTCTTGGCTCCCTGTGTCATTCCT
TAATTTAATGCCCCCCAAGAATGTTAATGTCAATCATGTCAGTGGACTAGCACATGGCAGTCGCTTGGAACCCACTCACACCAATCCAGT
GACCGTGTGTGGGCTGGCGGCTCTTCTCCCCCACCAACGGAACCCCTGTGTGCACCAACCTTCCCCAGAGCTCCGGAGCGCCCTCTCCTC
ACTTCCAGGTTTTGGAGCAAGAGCTTGCAGGAAGCCCGCACCCAGCTTCCTTCTGACCTTCAGTTCACTTTGTCGCCCTTGGAGAAAGCT

>96949_96949_1_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000349714_DYNLRB1_chr20_33114073_ENST00000357156_length(amino acids)=259AA_BP=164
MALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQWPQMSQSRACGGSEQIPGIDIQLNRKYHTTRKLSTTKDSPQPVEEKV
GAFTKIIEAMGFTGPLKYRCQMPDTFNSWFLITLLHVWMCLVRMKQEGRSGKYMCRIIVHFMWEDVQQRGRVMGAEVEETLKRLQSQKGV

--------------------------------------------------------------
>96949_96949_2_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000374380_DYNLRB1_chr20_33114073_ENST00000357156_length(transcript)=1059nt_BP=437nt
CAAAAGGAGGACGTAGAAAAGGGGACACCGGAAACTCACTCTTCACCCGGAAATGGTTATTGAGGAACATGGCGTTGCTGGTGCGAGTCC
TTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGTGTCTCCTACCCAAGGACAGGGGGACAGGGCTC
TGTCTCGCACTTCCCAGAAGATTAAGATTGCGGCCCTGCGCATGTATACTAGCTGTGTGGAGAAAACTGACTTCGAGGAATTCTTTCTAA
GGTGTCAGATGCCTGATACATTCAATTCATGGTTTCTTATAACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCC
GGAGTGGGAAGTACATGTGTCGTATCATAGTTCATTTTATGTGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGCAGAGGTGGAGG
AGACACTGAAGCGACTGCAGAGCCAGAAGGGAGTGCAGGGAATCATCGTCGTGAACACAGAAGGCATTCCCATCAAGAGCACCATGGACA
ACCCCACCACCACCCAGTATGCCAGCCTCATGCACAGCTTCATCCTGAAGGCACGGAGCACCGTGCGTGACATCGACCCCCAGAACGATC
TCACCTTCCTTCGAATTCGCTCCAAGAAAAATGAAATTATGGTTGCACCAGATAAAGACTATTTCCTGATTGTGATTCAGAATCCAACCG
AATAAGCCACTCTCTTGGCTCCCTGTGTCATTCCTTAATTTAATGCCCCCCAAGAATGTTAATGTCAATCATGTCAGTGGACTAGCACAT
GGCAGTCGCTTGGAACCCACTCACACCAATCCAGTGACCGTGTGTGGGCTGGCGGCTCTTCTCCCCCACCAACGGAACCCCTGTGTGCAC
CAACCTTCCCCAGAGCTCCGGAGCGCCCTCTCCTCACTTCCAGGTTTTGGAGCAAGAGCTTGCAGGAAGCCCGCACCCAGCTTCCTTCTG

>96949_96949_2_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000374380_DYNLRB1_chr20_33114073_ENST00000357156_length(amino acids)=221AA_BP=126
MRNMALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNSWFLITLLHVW
MCLVRMKQEGRSGKYMCRIIVHFMWEDVQQRGRVMGAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARS

--------------------------------------------------------------
>96949_96949_3_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000374384_DYNLRB1_chr20_33114073_ENST00000357156_length(transcript)=1205nt_BP=583nt
ATTGAGGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGT
GTCTCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGTGGCCCCAGATGAGCCAGTCCCGAGCATGTGGTGGATCAGA
ACAGATTCCTGGAATAGACATACAGCTGAATAGGAAGTATCACACCACACGTAAGCTTTCTACTACCAAAGATTCCCCACAGCCTGTTGA
GGAGAAGGTTGGTGCTTTCACAAAGATAATAGAAGCCATGGGATTCACGGGACCTTTGAAATACAGTAAATGGAAGATTAAGATTGCGGC
CCTGCGCATGTATACTAGCTGTGTGGAGAAAACTGACTTCGAGGAATTCTTTCTAAGGTGTCAGATGCCTGATACATTCAATTCATGGTT
TCTTATAACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCA
TTTTATGTGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGCAGAGGTGGAGGAGACACTGAAGCGACTGCAGAGCCAGAAGGGAGT
GCAGGGAATCATCGTCGTGAACACAGAAGGCATTCCCATCAAGAGCACCATGGACAACCCCACCACCACCCAGTATGCCAGCCTCATGCA
CAGCTTCATCCTGAAGGCACGGAGCACCGTGCGTGACATCGACCCCCAGAACGATCTCACCTTCCTTCGAATTCGCTCCAAGAAAAATGA
AATTATGGTTGCACCAGATAAAGACTATTTCCTGATTGTGATTCAGAATCCAACCGAATAAGCCACTCTCTTGGCTCCCTGTGTCATTCC
TTAATTTAATGCCCCCCAAGAATGTTAATGTCAATCATGTCAGTGGACTAGCACATGGCAGTCGCTTGGAACCCACTCACACCAATCCAG
TGACCGTGTGTGGGCTGGCGGCTCTTCTCCCCCACCAACGGAACCCCTGTGTGCACCAACCTTCCCCAGAGCTCCGGAGCGCCCTCTCCT
CACTTCCAGGTTTTGGAGCAAGAGCTTGCAGGAAGCCCGCACCCAGCTTCCTTCTGACCTTCAGTTCACTTTGTCGCCCTTGGAGAAAGC

>96949_96949_3_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000374384_DYNLRB1_chr20_33114073_ENST00000357156_length(amino acids)=289AA_BP=194
LRNMALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQWPQMSQSRACGGSEQIPGIDIQLNRKYHTTRKLSTTKDSPQPVE
EKVGAFTKIIEAMGFTGPLKYSKWKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNSWFLITLLHVWMCLVRMKQEGRSGKYMCRIIVH
FMWEDVQQRGRVMGAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDIDPQNDLTFLRIRSKKNE

--------------------------------------------------------------
>96949_96949_4_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000374385_DYNLRB1_chr20_33114073_ENST00000357156_length(transcript)=1373nt_BP=751nt
CAGGGAGAGCGTGCCCGGGCACGACAGCCTGGTGCACAGCCGAGAAAACAACAGCGCGTGCGCGTAGCGACCTCTTTGCGCCTGCGCCCC
CCTTGCCAGTCTTTCGCCGGCAAAAGGAGGACGTAGAAAAGGGGACACCGGAAACTCACTCTTCACCCGGAAATGGTTATTGAGGAACAT
GGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGTGTCTCCTACCCA
AGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGTGGCCCCAGATGAGCCAGTCCCGAGCATGTGGTGGATCAGAACAGATTCCTGG
AATAGACATACAGCTGAATAGGAAGTATCACACCACACGTAAGCTTTCTACTACCAAAGATTCCCCACAGCCTGTTGAGGAGAAGGTTGG
TGCTTTCACAAAGATAATAGAAGCCATGGGATTCACGGGACCTTTGAAATACAGTAAATGGAAGATTAAGATTGCGGCCCTGCGCATGTA
TACTAGCTGTGTGGAGAAAACTGACTTCGAGGAATTCTTTCTAAGGTGTCAGATGCCTGATACATTCAATTCATGGTTTCTTATAACCCT
ACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCATTTTATGTGGGA
GGATGTTCAGCAGCGCGGCAGAGTCATGGGGGCAGAGGTGGAGGAGACACTGAAGCGACTGCAGAGCCAGAAGGGAGTGCAGGGAATCAT
CGTCGTGAACACAGAAGGCATTCCCATCAAGAGCACCATGGACAACCCCACCACCACCCAGTATGCCAGCCTCATGCACAGCTTCATCCT
GAAGGCACGGAGCACCGTGCGTGACATCGACCCCCAGAACGATCTCACCTTCCTTCGAATTCGCTCCAAGAAAAATGAAATTATGGTTGC
ACCAGATAAAGACTATTTCCTGATTGTGATTCAGAATCCAACCGAATAAGCCACTCTCTTGGCTCCCTGTGTCATTCCTTAATTTAATGC
CCCCCAAGAATGTTAATGTCAATCATGTCAGTGGACTAGCACATGGCAGTCGCTTGGAACCCACTCACACCAATCCAGTGACCGTGTGTG
GGCTGGCGGCTCTTCTCCCCCACCAACGGAACCCCTGTGTGCACCAACCTTCCCCAGAGCTCCGGAGCGCCCTCTCCTCACTTCCAGGTT
TTGGAGCAAGAGCTTGCAGGAAGCCCGCACCCAGCTTCCTTCTGACCTTCAGTTCACTTTGTCGCCCTTGGAGAAAGCTGTTTTTCTTTA

>96949_96949_4_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000374385_DYNLRB1_chr20_33114073_ENST00000357156_length(amino acids)=289AA_BP=194
MRNMALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQWPQMSQSRACGGSEQIPGIDIQLNRKYHTTRKLSTTKDSPQPVE
EKVGAFTKIIEAMGFTGPLKYSKWKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNSWFLITLLHVWMCLVRMKQEGRSGKYMCRIIVH
FMWEDVQQRGRVMGAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASLMHSFILKARSTVRDIDPQNDLTFLRIRSKKNE

--------------------------------------------------------------
>96949_96949_5_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000397556_DYNLRB1_chr20_33114073_ENST00000357156_length(transcript)=1050nt_BP=428nt
GGGTTCCAGTATGCAGCCGATTGATACCTGTGTCTCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGCTTTCTACTA
CCAAAGATTCCCCACAGCCTGTTGAGGAGAAGGTTGGTGCTTTCACAAAGATAATAGAAGCCATGGGATTCACGGGACCTTTGAAATACA
GTAAATGGAAGATTAAGATTGCGGCCCTGCGCATGTATACTAGCTGTGTGGAGAAAACTGACTTCGAGGAATTCTTTCTAAGGTGTCAGA
TGCCTGATACATTCAATTCATGGTTTCTTATAACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGA
AGTACATGTGTCGTATCATAGTTCATTTTATGTGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGCAGAGGTGGAGGAGACACTGA
AGCGACTGCAGAGCCAGAAGGGAGTGCAGGGAATCATCGTCGTGAACACAGAAGGCATTCCCATCAAGAGCACCATGGACAACCCCACCA
CCACCCAGTATGCCAGCCTCATGCACAGCTTCATCCTGAAGGCACGGAGCACCGTGCGTGACATCGACCCCCAGAACGATCTCACCTTCC
TTCGAATTCGCTCCAAGAAAAATGAAATTATGGTTGCACCAGATAAAGACTATTTCCTGATTGTGATTCAGAATCCAACCGAATAAGCCA
CTCTCTTGGCTCCCTGTGTCATTCCTTAATTTAATGCCCCCCAAGAATGTTAATGTCAATCATGTCAGTGGACTAGCACATGGCAGTCGC
TTGGAACCCACTCACACCAATCCAGTGACCGTGTGTGGGCTGGCGGCTCTTCTCCCCCACCAACGGAACCCCTGTGTGCACCAACCTTCC
CCAGAGCTCCGGAGCGCCCTCTCCTCACTTCCAGGTTTTGGAGCAAGAGCTTGCAGGAAGCCCGCACCCAGCTTCCTTCTGACCTTCAGT

>96949_96949_5_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000397556_DYNLRB1_chr20_33114073_ENST00000357156_length(amino acids)=231AA_BP=136
MIPVSPTQGQGDRALSRTSQLSTTKDSPQPVEEKVGAFTKIIEAMGFTGPLKYSKWKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNS
WFLITLLHVWMCLVRMKQEGRSGKYMCRIIVHFMWEDVQQRGRVMGAEVEETLKRLQSQKGVQGIIVVNTEGIPIKSTMDNPTTTQYASL

--------------------------------------------------------------
>96949_96949_6_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000542501_DYNLRB1_chr20_33114073_ENST00000357156_length(transcript)=1074nt_BP=452nt
ATTGAGGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGT
GTCTCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGTGGCCCCAGATGAGCCAGTCCCGAGCATGTGGTGGATCAGA
ACAGATTCCTGGAATAGACATACAGCTGAATAGGAAGTATCACACCACACGTAAGCTTTCTACTACCAAAGATTCCCCACAGCCTGTTGA
GGAGAAGGTTGGTGCTTTCACAAAGATAATAGAAGCCATGGGATTCACGGGACCTTTGAAATACAGTAAATGGGATGTGTCTAGTCCGAA
TGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCATTTTATGTGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGG
GGGCAGAGGTGGAGGAGACACTGAAGCGACTGCAGAGCCAGAAGGGAGTGCAGGGAATCATCGTCGTGAACACAGAAGGCATTCCCATCA
AGAGCACCATGGACAACCCCACCACCACCCAGTATGCCAGCCTCATGCACAGCTTCATCCTGAAGGCACGGAGCACCGTGCGTGACATCG
ACCCCCAGAACGATCTCACCTTCCTTCGAATTCGCTCCAAGAAAAATGAAATTATGGTTGCACCAGATAAAGACTATTTCCTGATTGTGA
TTCAGAATCCAACCGAATAAGCCACTCTCTTGGCTCCCTGTGTCATTCCTTAATTTAATGCCCCCCAAGAATGTTAATGTCAATCATGTC
AGTGGACTAGCACATGGCAGTCGCTTGGAACCCACTCACACCAATCCAGTGACCGTGTGTGGGCTGGCGGCTCTTCTCCCCCACCAACGG
AACCCCTGTGTGCACCAACCTTCCCCAGAGCTCCGGAGCGCCCTCTCCTCACTTCCAGGTTTTGGAGCAAGAGCTTGCAGGAAGCCCGCA

>96949_96949_6_UQCC1-DYNLRB1_UQCC1_chr20_33934967_ENST00000542501_DYNLRB1_chr20_33114073_ENST00000357156_length(amino acids)=207AA_BP=150
LRNMALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQWPQMSQSRACGGSEQIPGIDIQLNRKYHTTRKLSTTKDSPQPVE
EKVGAFTKIIEAMGFTGPLKYSKWDVSSPNEAGRPEWEVHVSYHSSFYVGGCSAARQSHGGRGGGDTEATAEPEGSAGNHRREHRRHSHQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for UQCC1-DYNLRB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UQCC1-DYNLRB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UQCC1-DYNLRB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource