FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:UQCC1-MRPS35 (FusionGDB2 ID:96959)

Fusion Gene Summary for UQCC1-MRPS35

check button Fusion gene summary
Fusion gene informationFusion gene name: UQCC1-MRPS35
Fusion gene ID: 96959
HgeneTgene
Gene symbol

UQCC1

MRPS35

Gene ID

55245

60488

Gene nameubiquinol-cytochrome c reductase complex assembly factor 1mitochondrial ribosomal protein S35
SynonymsBFZB|C20orf44|CBP3|UQCCHDCMD11P|MDS023|MRP-S28|MRPS28
Cytomap

20q11.22

12p11.22

Type of geneprotein-codingprotein-coding
Descriptionubiquinol-cytochrome-c reductase complex assembly factor 1bFGF-repressed Zic-binding proteinbasic FGF-repressed Zic-binding proteincytochrome B protein synthesis 3 homologubiquinol-cytochrome c reductase complex chaperone CBP3 homolog28S ribosomal protein S35, mitochondrial28S ribosomal protein S28, mitochondrialMRP-S35S28mtS35mtmitochondrial ribosomal protein S28mitochondrial small ribosomal subunit protein mS35
Modification date2020031320200313
UniProtAcc.

P82673

Ensembl transtripts involved in fusion geneENST00000542501, ENST00000349714, 
ENST00000359226, ENST00000374377, 
ENST00000374380, ENST00000374385, 
ENST00000397556, ENST00000407996, 
ENST00000540457, ENST00000374384, 
ENST00000397554, ENST00000491125, 
ENST00000081029, ENST00000538315, 
Fusion gene scores* DoF score20 X 11 X 12=264015 X 8 X 7=840
# samples 2020
** MAII scorelog2(20/2640*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/840*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UQCC1 [Title/Abstract] AND MRPS35 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUQCC1(33902491)-MRPS35(27888380), # samples:2
Anticipated loss of major functional domain due to fusion event.UQCC1-MRPS35 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
UQCC1-MRPS35 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUQCC1

GO:0034551

mitochondrial respiratory chain complex III assembly

24385928

HgeneUQCC1

GO:0070131

positive regulation of mitochondrial translation

24385928


check buttonFusion gene breakpoints across UQCC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRPS35 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-6377-01AUQCC1chr20

33902491

-MRPS35chr12

27888380

+
ChimerDB4PRADTCGA-G9-6377UQCC1chr20

33902491

-MRPS35chr12

27888380

+


Top

Fusion Gene ORF analysis for UQCC1-MRPS35

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000542501ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
3UTR-intronENST00000542501ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
5CDS-intronENST00000349714ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
5CDS-intronENST00000359226ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
5CDS-intronENST00000374377ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
5CDS-intronENST00000374380ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
5CDS-intronENST00000374385ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
5CDS-intronENST00000397556ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
5CDS-intronENST00000407996ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
5CDS-intronENST00000540457ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
Frame-shiftENST00000374377ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
Frame-shiftENST00000540457ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
In-frameENST00000349714ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
In-frameENST00000359226ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
In-frameENST00000374380ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
In-frameENST00000374385ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
In-frameENST00000397556ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
In-frameENST00000407996ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
intron-3CDSENST00000374384ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
intron-3CDSENST00000397554ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
intron-3CDSENST00000491125ENST00000081029UQCC1chr20

33902491

-MRPS35chr12

27888380

+
intron-intronENST00000374384ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
intron-intronENST00000397554ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+
intron-intronENST00000491125ENST00000538315UQCC1chr20

33902491

-MRPS35chr12

27888380

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000349714UQCC1chr2033902491-ENST00000081029MRPS35chr1227888380+186557001019339
ENST00000359226UQCC1chr2033902491-ENST00000081029MRPS35chr1227888380+17134187867286
ENST00000374380UQCC1chr2033902491-ENST00000081029MRPS35chr1227888380+181051559964301
ENST00000374385UQCC1chr2033902491-ENST00000081029MRPS35chr1227888380+21248291691278369
ENST00000397556UQCC1chr2033902491-ENST00000081029MRPS35chr1227888380+180150620955311
ENST00000407996UQCC1chr2033902491-ENST00000081029MRPS35chr1227888380+15452501699232

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000349714ENST00000081029UQCC1chr2033902491-MRPS35chr1227888380+0.0003081340.99969184
ENST00000359226ENST00000081029UQCC1chr2033902491-MRPS35chr1227888380+0.0005640790.99943584
ENST00000374380ENST00000081029UQCC1chr2033902491-MRPS35chr1227888380+0.0003053920.9996946
ENST00000374385ENST00000081029UQCC1chr2033902491-MRPS35chr1227888380+0.0004346230.9995654
ENST00000397556ENST00000081029UQCC1chr2033902491-MRPS35chr1227888380+0.0009237150.99907625
ENST00000407996ENST00000081029UQCC1chr2033902491-MRPS35chr1227888380+0.0007974960.99920255

Top

Fusion Genomic Features for UQCC1-MRPS35


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
UQCC1chr2033902490-MRPS35chr1227888379+1.21E-060.9999988
UQCC1chr2033902490-MRPS35chr1227888379+1.21E-060.9999988
UQCC1chr2033902490-MRPS35chr1227888379+1.21E-060.9999988
UQCC1chr2033902490-MRPS35chr1227888379+1.21E-060.9999988

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for UQCC1-MRPS35


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:33902491/chr12:27888380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MRPS35

P82673

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMRPS35chr20:33902491chr12:27888380ENST0000008102948257_321174324.0Coiled coilOntology_term=ECO:0000255
TgeneMRPS35chr20:33902491chr12:27888380ENST0000053831507257_3210526.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for UQCC1-MRPS35


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96959_96959_1_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000349714_MRPS35_chr12_27888380_ENST00000081029_length(transcript)=1865nt_BP=570nt
ATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGTGTCTCCTACC
CAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGTGGCCCCAGATGAGCCAGTCCCGAGCATGTGGTGGATCAGAACAGATTCCT
GGAATAGACATACAGCTGAATAGGAAGTATCACACCACACGTAAGCTTTCTACTACCAAAGATTCCCCACAGCCTGTTGAGGAGAAGGTT
GGTGCTTTCACAAAGATAATAGAAGCCATGGGATTCACGGGACCTTTGAAATACAGGTGTCAGATGCCTGATACATTCAATTCATGGTTT
CTTATAACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCAT
TTTATGTGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGTTAATCCCTATATCCTGAAGAAGAACATGATCCTCATGACAAATCAT
TTCTATGCAGCGATCTTGGGATATGATGAGGTAAAGCTTTCCAGTTTGAATTTAGATGATCACGCAAAGAAGAAATTAATTAAACTTGTA
GGAGAGCGATACTGCAAGACCACAGATGTGCTTACCATCAAAACAGATAGGTGCCCTTTAAGGAGGCAGAATTACGATTATGCAGTGTAT
CTACTAACAGTGTTATACCATGAGTCTTGGAATACTGAAGAATGGGAAAAAAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGAA
AATAGCTCATCAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCTT
GGTACTAAAGAAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGAA
TCCGTGAAGAGACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCTGCTTGATTTATTAATTTTATGATATATGTGATCAGTATCT
AATTTGATATAAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATGA
TTACTCCAGAGTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTC
TACATAATAGCTTTGGTATTCATGTATATACATGCATTTAATTGTGATTTTATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTC
AGTAGTTGCTTTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACA
TGACTGCTGTCTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGAAACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCTA
AAAAGATATGTTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAA
GTGGAGATTACCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATGT
AATTGGAGTAAGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCAATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCAG

>96959_96959_1_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000349714_MRPS35_chr12_27888380_ENST00000081029_length(amino acids)=339AA_BP=190
MALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQWPQMSQSRACGGSEQIPGIDIQLNRKYHTTRKLSTTKDSPQPVEEKV
GAFTKIIEAMGFTGPLKYRCQMPDTFNSWFLITLLHVWMCLVRMKQEGRSGKYMCRIIVHFMWEDVQQRGRVMGVNPYILKKNMILMTNH
FYAAILGYDEVKLSSLNLDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWE

--------------------------------------------------------------
>96959_96959_2_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000359226_MRPS35_chr12_27888380_ENST00000081029_length(transcript)=1713nt_BP=418nt
GAGGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGTGTC
TCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGTGGCCCCAGATGAGCCAGTCCCGAGCATGTGGTGGATCAGAACA
GATTCCTGGAATAGACATACAGCTGAATAGGAAGTATCACACCACACGTAAGCTTTCTACTACCAAAGATTCCCCACAGCCTGTTGAGGA
GAAGGTTGGTGCTTTCACAAAGATAATAGAAGCCATGGGATTCACGGGACCTTTGAAATACAGTAAATGGGTTAATCCCTATATCCTGAA
GAAGAACATGATCCTCATGACAAATCATTTCTATGCAGCGATCTTGGGATATGATGAGGTAAAGCTTTCCAGTTTGAATTTAGATGATCA
CGCAAAGAAGAAATTAATTAAACTTGTAGGAGAGCGATACTGCAAGACCACAGATGTGCTTACCATCAAAACAGATAGGTGCCCTTTAAG
GAGGCAGAATTACGATTATGCAGTGTATCTACTAACAGTGTTATACCATGAGTCTTGGAATACTGAAGAATGGGAAAAAAGTAAGACTGA
AGCAGACATGGAAGAGTATATATGGGAAAATAGCTCATCAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTGAGAAAAA
TATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGGAGGAAAA
TGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAGACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCTGCTTGATTTATT
AATTTTATGATATATGTGATCAGTATCTAATTTGATATAAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAAATTATTT
CCCTCATACTAATGCTTAATGGCAATGATTACTCCAGAGTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGATTTCTTC
TTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGCTTTGGTATTCATGTATATACATGCATTTAATTGTGATTTTATCACCTTTCC
CATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCCATTTCCT
TGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTCTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGAAACAGGTCCTCA
GGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATGTTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCTCATTTTG
CCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTACCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGCTCAGGAA
AAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTAAGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCAATGTAGCTGTCA
ATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTACCACTTCGATGGTTGTGATTAATTTAAAATCAAAATAAAGGAATTACTGAGT

>96959_96959_2_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000359226_MRPS35_chr12_27888380_ENST00000081029_length(amino acids)=286AA_BP=137
MALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQWPQMSQSRACGGSEQIPGIDIQLNRKYHTTRKLSTTKDSPQPVEEKV
GAFTKIIEAMGFTGPLKYSKWVNPYILKKNMILMTNHFYAAILGYDEVKLSSLNLDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLRRQ
NYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEELLGTKEIEEYKKSVVSLKNEEENEN

--------------------------------------------------------------
>96959_96959_3_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000374380_MRPS35_chr12_27888380_ENST00000081029_length(transcript)=1810nt_BP=515nt
CAAAAGGAGGACGTAGAAAAGGGGACACCGGAAACTCACTCTTCACCCGGAAATGGTTATTGAGGAACATGGCGTTGCTGGTGCGAGTCC
TTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGTGTCTCCTACCCAAGGACAGGGGGACAGGGCTC
TGTCTCGCACTTCCCAGAAGATTAAGATTGCGGCCCTGCGCATGTATACTAGCTGTGTGGAGAAAACTGACTTCGAGGAATTCTTTCTAA
GGTGTCAGATGCCTGATACATTCAATTCATGGTTTCTTATAACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCC
GGAGTGGGAAGTACATGTGTCGTATCATAGTTCATTTTATGTGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGTTAATCCCTATA
TCCTGAAGAAGAACATGATCCTCATGACAAATCATTTCTATGCAGCGATCTTGGGATATGATGAGGTAAAGCTTTCCAGTTTGAATTTAG
ATGATCACGCAAAGAAGAAATTAATTAAACTTGTAGGAGAGCGATACTGCAAGACCACAGATGTGCTTACCATCAAAACAGATAGGTGCC
CTTTAAGGAGGCAGAATTACGATTATGCAGTGTATCTACTAACAGTGTTATACCATGAGTCTTGGAATACTGAAGAATGGGAAAAAAGTA
AGACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCATCAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTG
AGAAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGG
AGGAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAGACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCTGCTTG
ATTTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATATAAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAA
ATTATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGAGTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGA
TTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGCTTTGGTATTCATGTATATACATGCATTTAATTGTGATTTTATCA
CCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCC
ATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTCTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGAAACAG
GTCCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATGTTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCT
CATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTACCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGC
TCAGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTAAGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCAATGTA
GCTGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTACCACTTCGATGGTTGTGATTAATTTAAAATCAAAATAAAGGAATT

>96959_96959_3_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000374380_MRPS35_chr12_27888380_ENST00000081029_length(amino acids)=301AA_BP=152
MRNMALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNSWFLITLLHVW
MCLVRMKQEGRSGKYMCRIIVHFMWEDVQQRGRVMGVNPYILKKNMILMTNHFYAAILGYDEVKLSSLNLDDHAKKKLIKLVGERYCKTT
DVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEELLGTKEIEEY

--------------------------------------------------------------
>96959_96959_4_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000374385_MRPS35_chr12_27888380_ENST00000081029_length(transcript)=2124nt_BP=829nt
CAGGGAGAGCGTGCCCGGGCACGACAGCCTGGTGCACAGCCGAGAAAACAACAGCGCGTGCGCGTAGCGACCTCTTTGCGCCTGCGCCCC
CCTTGCCAGTCTTTCGCCGGCAAAAGGAGGACGTAGAAAAGGGGACACCGGAAACTCACTCTTCACCCGGAAATGGTTATTGAGGAACAT
GGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGTGTCTCCTACCCA
AGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGTGGCCCCAGATGAGCCAGTCCCGAGCATGTGGTGGATCAGAACAGATTCCTGG
AATAGACATACAGCTGAATAGGAAGTATCACACCACACGTAAGCTTTCTACTACCAAAGATTCCCCACAGCCTGTTGAGGAGAAGGTTGG
TGCTTTCACAAAGATAATAGAAGCCATGGGATTCACGGGACCTTTGAAATACAGTAAATGGAAGATTAAGATTGCGGCCCTGCGCATGTA
TACTAGCTGTGTGGAGAAAACTGACTTCGAGGAATTCTTTCTAAGGTGTCAGATGCCTGATACATTCAATTCATGGTTTCTTATAACCCT
ACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCATTTTATGTGGGA
GGATGTTCAGCAGCGCGGCAGAGTCATGGGGGTTAATCCCTATATCCTGAAGAAGAACATGATCCTCATGACAAATCATTTCTATGCAGC
GATCTTGGGATATGATGAGGTAAAGCTTTCCAGTTTGAATTTAGATGATCACGCAAAGAAGAAATTAATTAAACTTGTAGGAGAGCGATA
CTGCAAGACCACAGATGTGCTTACCATCAAAACAGATAGGTGCCCTTTAAGGAGGCAGAATTACGATTATGCAGTGTATCTACTAACAGT
GTTATACCATGAGTCTTGGAATACTGAAGAATGGGAAAAAAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCATC
AGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGA
AATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAG
ACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCTGCTTGATTTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATATA
AAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGAG
TTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGC
TTTGGTATTCATGTATATACATGCATTTAATTGTGATTTTATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTT
TTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTC
TAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGAAACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATGT
TGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTAC
CTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTAA
GTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCAATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTAC

>96959_96959_4_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000374385_MRPS35_chr12_27888380_ENST00000081029_length(amino acids)=369AA_BP=220
MRNMALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQWPQMSQSRACGGSEQIPGIDIQLNRKYHTTRKLSTTKDSPQPVE
EKVGAFTKIIEAMGFTGPLKYSKWKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNSWFLITLLHVWMCLVRMKQEGRSGKYMCRIIVH
FMWEDVQQRGRVMGVNPYILKKNMILMTNHFYAAILGYDEVKLSSLNLDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLRRQNYDYAVY
LLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEELLGTKEIEEYKKSVVSLKNEEENENSISQYKE

--------------------------------------------------------------
>96959_96959_5_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000397556_MRPS35_chr12_27888380_ENST00000081029_length(transcript)=1801nt_BP=506nt
GGGTTCCAGTATGCAGCCGATTGATACCTGTGTCTCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGCTTTCTACTA
CCAAAGATTCCCCACAGCCTGTTGAGGAGAAGGTTGGTGCTTTCACAAAGATAATAGAAGCCATGGGATTCACGGGACCTTTGAAATACA
GTAAATGGAAGATTAAGATTGCGGCCCTGCGCATGTATACTAGCTGTGTGGAGAAAACTGACTTCGAGGAATTCTTTCTAAGGTGTCAGA
TGCCTGATACATTCAATTCATGGTTTCTTATAACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGA
AGTACATGTGTCGTATCATAGTTCATTTTATGTGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGTTAATCCCTATATCCTGAAGA
AGAACATGATCCTCATGACAAATCATTTCTATGCAGCGATCTTGGGATATGATGAGGTAAAGCTTTCCAGTTTGAATTTAGATGATCACG
CAAAGAAGAAATTAATTAAACTTGTAGGAGAGCGATACTGCAAGACCACAGATGTGCTTACCATCAAAACAGATAGGTGCCCTTTAAGGA
GGCAGAATTACGATTATGCAGTGTATCTACTAACAGTGTTATACCATGAGTCTTGGAATACTGAAGAATGGGAAAAAAGTAAGACTGAAG
CAGACATGGAAGAGTATATATGGGAAAATAGCTCATCAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGCTGCTGAGAAAAATA
TGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAATGAGGAGGAAAATG
AAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAGACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCTGCTTGATTTATTAA
TTTTATGATATATGTGATCAGTATCTAATTTGATATAAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAGTTAAAATTATTTCC
CTCATACTAATGCTTAATGGCAATGATTACTCCAGAGTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTCTCTGATTTCTTCTT
GGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGCTTTGGTATTCATGTATATACATGCATTTAATTGTGATTTTATCACCTTTCCCA
TTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAGAACCCATTTCCTTG
ACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTCTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGAAACAGGTCCTCAGG
AGTATTCTCTAACCTGATATTTTCTAAAAAGATATGTTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTGGGGCTCATTTTGCC
AGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTACCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCCACAGCTCAGGAAAA
AGATGAGGCATAACGACCTTGAATGTAATTGGAGTAAGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCAATGTAGCTGTCAAT
TCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTACCACTTCGATGGTTGTGATTAATTTAAAATCAAAATAAAGGAATTACTGAGTTT

>96959_96959_5_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000397556_MRPS35_chr12_27888380_ENST00000081029_length(amino acids)=311AA_BP=162
MIPVSPTQGQGDRALSRTSQLSTTKDSPQPVEEKVGAFTKIIEAMGFTGPLKYSKWKIKIAALRMYTSCVEKTDFEEFFLRCQMPDTFNS
WFLITLLHVWMCLVRMKQEGRSGKYMCRIIVHFMWEDVQQRGRVMGVNPYILKKNMILMTNHFYAAILGYDEVKLSSLNLDDHAKKKLIK
LVGERYCKTTDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKAAEKNMEINKEE

--------------------------------------------------------------
>96959_96959_6_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000407996_MRPS35_chr12_27888380_ENST00000081029_length(transcript)=1545nt_BP=250nt
ATTGAGGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGT
GTCTCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGTGGCCCCAGATGAGCCAGTCCCGAGCATGTGGTGGATCAGA
ACAGATTCCTGGAATAGACATACAGCTGAATAGGAAGTATCACACCACACCGATCTTGGGATATGATGAGGTAAAGCTTTCCAGTTTGAA
TTTAGATGATCACGCAAAGAAGAAATTAATTAAACTTGTAGGAGAGCGATACTGCAAGACCACAGATGTGCTTACCATCAAAACAGATAG
GTGCCCTTTAAGGAGGCAGAATTACGATTATGCAGTGTATCTACTAACAGTGTTATACCATGAGTCTTGGAATACTGAAGAATGGGAAAA
AAGTAAGACTGAAGCAGACATGGAAGAGTATATATGGGAAAATAGCTCATCAGAAAGAAATATCCTGGAAACGCTTCTCCAGATGAAAGC
TGCTGAGAAAAATATGGAAATAAATAAAGAAGAGCTCCTTGGTACTAAAGAAATTGAAGAGTACAAAAAGTCTGTTGTTAGTCTTAAAAA
TGAGGAGGAAAATGAAAATTCCATTTCTCAGTACAAAGAATCCGTGAAGAGACTATTAAATGTGACATGAATTATGGAGTAGAAAAATCT
GCTTGATTTATTAATTTTATGATATATGTGATCAGTATCTAATTTGATATAAAATTGAAAATGTTAAAAAATCATTTTTTTTCCTCAGAG
TTAAAATTATTTCCCTCATACTAATGCTTAATGGCAATGATTACTCCAGAGTTTTTTAATTTTTACACTGGGGCAATAGACTAGGAGGTC
TCTGATTTCTTCTTGGTCTAAAGTGTTTTGATTTTATTTCTACATAATAGCTTTGGTATTCATGTATATACATGCATTTAATTGTGATTT
TATCACCTTTCCCATTTCTTTCCCCACAAGCTGGCATTTCAGTAGTTGCTTTTGAATAATGGTTTTGGTTACCTGGGAAGGCAGGCCCAG
AACCCATTTCCTTGACTTGCAGTTCCGGGCTGTGTTCACATGACTGCTGTCTAGCTGATGCATTTTTCACATTTGTCAACTCTGGTTAGA
AACAGGTCCTCAGGAGTATTCTCTAACCTGATATTTTCTAAAAAGATATGTTGATTCAACTTTGTTTAGCATCCTACTTTCTAGATTGTG
GGGCTCATTTTGCCAGGGCCAAGCTACCAGAAAAGTAGAAGTGGAGATTACCTGGTATGTATCTCTCTGGGTGCCCCAGTTAGAGCTGCC
ACAGCTCAGGAAAAAGATGAGGCATAACGACCTTGAATGTAATTGGAGTAAGTGACAAAATAAGAACTACCCTGGGAAACCCTGCATTCA
ATGTAGCTGTCAATTCAGTATTTTTAAGTACACCTGTCAGCTGTTTCTTACCACTTCGATGGTTGTGATTAATTTAAAATCAAAATAAAG

>96959_96959_6_UQCC1-MRPS35_UQCC1_chr20_33902491_ENST00000407996_MRPS35_chr12_27888380_ENST00000081029_length(amino acids)=232AA_BP=83
LRNMALLVRVLRNQTSISQWVPVCSRLIPVSPTQGQGDRALSRTSQWPQMSQSRACGGSEQIPGIDIQLNRKYHTTPILGYDEVKLSSLN
LDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLRRQNYDYAVYLLTVLYHESWNTEEWEKSKTEADMEEYIWENSSSERNILETLLQMKA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for UQCC1-MRPS35


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for UQCC1-MRPS35


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for UQCC1-MRPS35


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource