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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:UQCC1-TACC1 (FusionGDB2 ID:96965)

Fusion Gene Summary for UQCC1-TACC1

check button Fusion gene summary
Fusion gene informationFusion gene name: UQCC1-TACC1
Fusion gene ID: 96965
HgeneTgene
Gene symbol

UQCC1

TACC1

Gene ID

55245

6867

Gene nameubiquinol-cytochrome c reductase complex assembly factor 1transforming acidic coiled-coil containing protein 1
SynonymsBFZB|C20orf44|CBP3|UQCCGa55
Cytomap

20q11.22

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionubiquinol-cytochrome-c reductase complex assembly factor 1bFGF-repressed Zic-binding proteinbasic FGF-repressed Zic-binding proteincytochrome B protein synthesis 3 homologubiquinol-cytochrome c reductase complex chaperone CBP3 homologtransforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1
Modification date2020031320200320
UniProtAcc.

O75410

Ensembl transtripts involved in fusion geneENST00000349714, ENST00000374377, 
ENST00000374380, ENST00000374384, 
ENST00000374385, ENST00000397556, 
ENST00000540457, ENST00000542501, 
ENST00000491125, ENST00000359226, 
ENST00000397554, ENST00000407996, 
ENST00000276520, ENST00000317827, 
ENST00000330691, ENST00000348567, 
ENST00000379931, ENST00000520973, 
ENST00000522752, ENST00000520611, 
ENST00000443286, ENST00000518415, 
ENST00000519416, ENST00000520340, 
ENST00000520615, 
Fusion gene scores* DoF score20 X 11 X 12=264018 X 21 X 10=3780
# samples 2023
** MAII scorelog2(20/2640*10)=-3.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3780*10)=-4.03868046816406
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UQCC1 [Title/Abstract] AND TACC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUQCC1(33934967)-TACC1(38682826), # samples:1
Anticipated loss of major functional domain due to fusion event.UQCC1-TACC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUQCC1

GO:0034551

mitochondrial respiratory chain complex III assembly

24385928

HgeneUQCC1

GO:0070131

positive regulation of mitochondrial translation

24385928


check buttonFusion gene breakpoints across UQCC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TACC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-2677-01AUQCC1chr20

33934967

-TACC1chr8

38682826

+


Top

Fusion Gene ORF analysis for UQCC1-TACC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000349714ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000349714ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000349714ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000349714ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000349714ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000349714ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000349714ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374377ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374377ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374377ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374377ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374377ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374377ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374377ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374380ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374380ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374380ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374380ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374380ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374380ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374380ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374384ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374384ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374384ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374384ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374384ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374384ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374384ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374385ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374385ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374385ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374385ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374385ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374385ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000374385ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000397556ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000397556ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000397556ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000397556ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000397556ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000397556ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000397556ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000540457ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000540457ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000540457ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000540457ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000540457ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000540457ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000540457ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000542501ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000542501ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000542501ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000542501ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000542501ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000542501ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-3UTRENST00000542501ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-intronENST00000349714ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-intronENST00000374377ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-intronENST00000374380ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-intronENST00000374384ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-intronENST00000374385ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-intronENST00000397556ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-intronENST00000540457ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
5CDS-intronENST00000542501ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3CDSENST00000491125ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3CDSENST00000491125ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3CDSENST00000491125ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3CDSENST00000491125ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3CDSENST00000491125ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3UTRENST00000491125ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3UTRENST00000491125ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3UTRENST00000491125ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3UTRENST00000491125ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3UTRENST00000491125ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3UTRENST00000491125ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-3UTRENST00000491125ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
5UTR-intronENST00000491125ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000349714ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000349714ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000349714ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000349714ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000349714ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374380ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374380ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374380ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374380ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374380ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374384ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374384ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374384ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374384ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374384ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374385ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374385ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374385ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374385ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000374385ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000397556ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000397556ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000397556ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000397556ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000397556ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000540457ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000540457ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000540457ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000540457ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000540457ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000542501ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000542501ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000542501ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000542501ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
Frame-shiftENST00000542501ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
In-frameENST00000374377ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
In-frameENST00000374377ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
In-frameENST00000374377ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
In-frameENST00000374377ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
In-frameENST00000374377ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000359226ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000359226ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000359226ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000359226ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000359226ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000397554ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000397554ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000397554ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000397554ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000397554ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000407996ENST00000443286UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000407996ENST00000518415UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000407996ENST00000519416UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000407996ENST00000520340UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3CDSENST00000407996ENST00000520615UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000359226ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000359226ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000359226ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000359226ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000359226ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000359226ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000359226ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000397554ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000397554ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000397554ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000397554ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000397554ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000397554ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000397554ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000407996ENST00000276520UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000407996ENST00000317827UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000407996ENST00000330691UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000407996ENST00000348567UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000407996ENST00000379931UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000407996ENST00000520973UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-3UTRENST00000407996ENST00000522752UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-intronENST00000359226ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-intronENST00000397554ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+
intron-intronENST00000407996ENST00000520611UQCC1chr20

33934967

-TACC1chr8

38682826

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374377UQCC1chr2033934967-ENST00000519416TACC1chr838682826+41003062771329350
ENST00000374377UQCC1chr2033934967-ENST00000520615TACC1chr838682826+41033062771332351
ENST00000374377UQCC1chr2033934967-ENST00000443286TACC1chr838682826+13383062771245322
ENST00000374377UQCC1chr2033934967-ENST00000520340TACC1chr838682826+867306277765162
ENST00000374377UQCC1chr2033934967-ENST00000518415TACC1chr838682826+13553062771245322

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374377ENST00000519416UQCC1chr2033934967-TACC1chr838682826+0.0004738530.99952614
ENST00000374377ENST00000520615UQCC1chr2033934967-TACC1chr838682826+0.000142750.9998572
ENST00000374377ENST00000443286UQCC1chr2033934967-TACC1chr838682826+0.0022532070.99774677
ENST00000374377ENST00000520340UQCC1chr2033934967-TACC1chr838682826+0.0044911040.9955089
ENST00000374377ENST00000518415UQCC1chr2033934967-TACC1chr838682826+0.0022402380.9977597

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Fusion Genomic Features for UQCC1-TACC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
UQCC1chr2033934966-TACC1chr838682825+8.68E-050.9999132
UQCC1chr2033934966-TACC1chr838682825+8.68E-050.9999132

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for UQCC1-TACC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:33934967/chr8:38682826)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TACC1

O75410

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTACC1chr20:33934967chr8:38682826ENST00000276520011610_80553396.0Coiled coil.
TgeneTACC1chr20:33934967chr8:38682826ENST00000317827213610_805463806.0Coiled coil.
TgeneTACC1chr20:33934967chr8:38682826ENST00000330691112610_80537380.0Coiled coil.
TgeneTACC1chr20:33934967chr8:38682826ENST00000348567011610_80525368.0Coiled coil.
TgeneTACC1chr20:33934967chr8:38682826ENST00000379931314610_805475818.0Coiled coil.
TgeneTACC1chr20:33934967chr8:38682826ENST00000518415415610_805418732.0Coiled coil.
TgeneTACC1chr20:33934967chr8:38682826ENST00000520615213610_805268611.0Coiled coil.
TgeneTACC1chr20:33934967chr8:38682826ENST00000276520011215_29753396.0DomainNote=SPAZ 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000276520011359_50753396.0DomainNote=SPAZ 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000330691112215_29737380.0DomainNote=SPAZ 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000330691112359_50737380.0DomainNote=SPAZ 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000348567011215_29725368.0DomainNote=SPAZ 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000348567011359_50725368.0DomainNote=SPAZ 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000520615213359_507268611.0DomainNote=SPAZ 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000276520011226_24153396.0MotifBipartite nuclear localization signal 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000276520011455_47153396.0MotifBipartite nuclear localization signal 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000330691112226_24137380.0MotifBipartite nuclear localization signal 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000330691112455_47137380.0MotifBipartite nuclear localization signal 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000348567011226_24125368.0MotifBipartite nuclear localization signal 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000348567011455_47125368.0MotifBipartite nuclear localization signal 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000518415415455_471418732.0MotifBipartite nuclear localization signal 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000520615213455_471268611.0MotifBipartite nuclear localization signal 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTACC1chr20:33934967chr8:38682826ENST00000317827213215_297463806.0DomainNote=SPAZ 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000317827213359_507463806.0DomainNote=SPAZ 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000379931314215_297475818.0DomainNote=SPAZ 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000379931314359_507475818.0DomainNote=SPAZ 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000518415415215_297418732.0DomainNote=SPAZ 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000518415415359_507418732.0DomainNote=SPAZ 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000520615213215_297268611.0DomainNote=SPAZ 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000317827213226_241463806.0MotifBipartite nuclear localization signal 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000317827213455_471463806.0MotifBipartite nuclear localization signal 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000379931314226_241475818.0MotifBipartite nuclear localization signal 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000379931314455_471475818.0MotifBipartite nuclear localization signal 2
TgeneTACC1chr20:33934967chr8:38682826ENST00000518415415226_241418732.0MotifBipartite nuclear localization signal 1
TgeneTACC1chr20:33934967chr8:38682826ENST00000520615213226_241268611.0MotifBipartite nuclear localization signal 1


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Fusion Gene Sequence for UQCC1-TACC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>96965_96965_1_UQCC1-TACC1_UQCC1_chr20_33934967_ENST00000374377_TACC1_chr8_38682826_ENST00000443286_length(transcript)=1338nt_BP=306nt
ATTGAGGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGT
GTCTCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGGGTGTCAGATGCCTGATACATTCAATTCATGGTTTCTTATA
ACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCATTTTATG
TGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGAGTGGCTGTAAGGTGAAGAAGCATGAAACTCAGTCTCTCGCCCTGGATGCATG
TTCTCGGGATGAAGGGGCAGTGATCTCCCAGATTTCAGACATTTCTAATAGGGATGGCCATGCTACTGATGAGGAGAAACTGGCATCCAC
GTCATGTGGTCAGAAATCAGCTGGTGCCGAGGTGAAAGGCATAGAGAAGGAGACGTGCCAGAAGATGGAAGAAGACGGGTCCACTGTGCT
TGGGCTGCTGGAGTCCTCTGCAGAGAAGGCCCCTGTGTCGGTGTCCTGTGGAGGTGAGAGCCCCCTGGATGGGATCTGCCTCAGCGAATC
AGACAAGACAGCCGTGCTCACCTTAATAAGAGAAGAGATAATTACTAAAGAGATTGAAGCAAATGAATGGAAGAAGAAATACGAAGAGAC
CCGGCAAGAAGTTTTGGAGATGAGGAAAATTGTAGCTGAATATGAAAAGACTATTGCTCAAATGATTGAAGATGAACAAAGGACAAGTAT
GACCTCTCAGAAGAGCTTCCAGCAACTGACCATGGAGAAGGAACAGGCCCTGGCTGACCTTAACTCTGTGGAAAGGTCCCTTTCTGATCT
CTTCAGGAGATATGAGAACCTGAAAGGTGTTCTGGAAGGGTTCAAGAAGAATGAAGAAGCCTTGAAGAAATGTGCTCAGGATTACTTAGC
CAGAGTTAAACAAGAGGAGCAGCGATACCAGGCCCTGAAAATCCACGCAGAAGAGAAACTGGACAAAGCCAATGAAGAGATTGCTCAGGT
TCGAACAAAAGCAAAGGCTGAGAGTGCAGCTCTCCATGCTGGACTCCGCAAAGAGCAGATGAAGGTGGAGTCCCTGGAAAGGGCCCTGCA
GCAGAAGAACCAAGAAATTGAAGAACTGACAAAAATCTGTGATGAGCTGATTGCAAAGCTGGGAAAGACTGACTGAGACACTCCCCCTGT

>96965_96965_1_UQCC1-TACC1_UQCC1_chr20_33934967_ENST00000374377_TACC1_chr8_38682826_ENST00000443286_length(amino acids)=322AA_BP=10
MFSSAAESWGSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGIEKETCQKMEEDGSTVLGL
LESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTS
QKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRT

--------------------------------------------------------------
>96965_96965_2_UQCC1-TACC1_UQCC1_chr20_33934967_ENST00000374377_TACC1_chr8_38682826_ENST00000518415_length(transcript)=1355nt_BP=306nt
ATTGAGGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGT
GTCTCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGGGTGTCAGATGCCTGATACATTCAATTCATGGTTTCTTATA
ACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCATTTTATG
TGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGAGTGGCTGTAAGGTGAAGAAGCATGAAACTCAGTCTCTCGCCCTGGATGCATG
TTCTCGGGATGAAGGGGCAGTGATCTCCCAGATTTCAGACATTTCTAATAGGGATGGCCATGCTACTGATGAGGAGAAACTGGCATCCAC
GTCATGTGGTCAGAAATCAGCTGGTGCCGAGGTGAAAGGCATAGAGAAGGAGACGTGCCAGAAGATGGAAGAAGACGGGTCCACTGTGCT
TGGGCTGCTGGAGTCCTCTGCAGAGAAGGCCCCTGTGTCGGTGTCCTGTGGAGGTGAGAGCCCCCTGGATGGGATCTGCCTCAGCGAATC
AGACAAGACAGCCGTGCTCACCTTAATAAGAGAAGAGATAATTACTAAAGAGATTGAAGCAAATGAATGGAAGAAGAAATACGAAGAGAC
CCGGCAAGAAGTTTTGGAGATGAGGAAAATTGTAGCTGAATATGAAAAGACTATTGCTCAAATGATTGAAGATGAACAAAGGACAAGTAT
GACCTCTCAGAAGAGCTTCCAGCAACTGACCATGGAGAAGGAACAGGCCCTGGCTGACCTTAACTCTGTGGAAAGGTCCCTTTCTGATCT
CTTCAGGAGATATGAGAACCTGAAAGGTGTTCTGGAAGGGTTCAAGAAGAATGAAGAAGCCTTGAAGAAATGTGCTCAGGATTACTTAGC
CAGAGTTAAACAAGAGGAGCAGCGATACCAGGCCCTGAAAATCCACGCAGAAGAGAAACTGGACAAAGCCAATGAAGAGATTGCTCAGGT
TCGAACAAAAGCAAAGGCTGAGAGTGCAGCTCTCCATGCTGGACTCCGCAAAGAGCAGATGAAGGTGGAGTCCCTGGAAAGGGCCCTGCA
GCAGAAGAACCAAGAAATTGAAGAACTGACAAAAATCTGTGATGAGCTGATTGCAAAGCTGGGAAAGACTGACTGAGACACTCCCCCTGT
TAGCTCAACAGATCTGCATTTGGCTGCTTCTCTTGTGACCACAATTATCTTGCCTTATCCAGGAATAATTGCCCCTTTGCAGAGAAAAAA

>96965_96965_2_UQCC1-TACC1_UQCC1_chr20_33934967_ENST00000374377_TACC1_chr8_38682826_ENST00000518415_length(amino acids)=322AA_BP=10
MFSSAAESWGSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGIEKETCQKMEEDGSTVLGL
LESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTS
QKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRT

--------------------------------------------------------------
>96965_96965_3_UQCC1-TACC1_UQCC1_chr20_33934967_ENST00000374377_TACC1_chr8_38682826_ENST00000519416_length(transcript)=4100nt_BP=306nt
ATTGAGGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGT
GTCTCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGGGTGTCAGATGCCTGATACATTCAATTCATGGTTTCTTATA
ACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCATTTTATG
TGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGTGGCTGTAAGGTGAAGAAGCATGAAACTCAGTCTCTCGCCCTGGATGCATGTTC
TCGGGATGAAGGGGCAGTGATCTCCCAGATTTCAGACATTTCTAATAGGGATGGCCATGCTACTGATGAGGAGAAACTGGCATCCACGTC
ATGTGGTCAGAAATCAGCTGGTGCCGAGGTGAAAGGTGAGCCAGAGGAAGACCTGGAGTACTTTGAATGTTCCAATGTTCCTGTGTCTAC
CATAAATCATGCGTTTTCATCCTCAGAAGCAGGCATAGAGAAGGAGACGTGCCAGAAGATGGAAGAAGACGGGTCCACTGTGCTTGGGCT
GCTGGAGTCCTCTGCAGAGAAGGCCCCTGTGTCGGTGTCCTGTGGAGGTGAGAGCCCCCTGGATGGGATCTGCCTCAGCGAATCAGACAA
GACAGCCGTGCTCACCTTAATAAGAGAAGAGATAATTACTAAAGAGATTGAAGCAAATGAATGGAAGAAGAAATACGAAGAGACCCGGCA
AGAAGTTTTGGAGATGAGGAAAATTGTAGCTGAATATGAAAAGACTATTGCTCAAATGATTGAAGATGAACAAAGGACAAGTATGACCTC
TCAGAAGAGCTTCCAGCAACTGACCATGGAGAAGGAACAGGCCCTGGCTGACCTTAACTCTGTGGAAAGGTCCCTTTCTGATCTCTTCAG
GAGATATGAGAACCTGAAAGGTGTTCTGGAAGGGTTCAAGAAGAATGAAGAAGCCTTGAAGAAATGTGCTCAGGATTACTTAGCCAGAGT
TAAACAAGAGGAGCAGCGATACCAGGCCCTGAAAATCCACGCAGAAGAGAAACTGGACAAAGCCAATGAAGAGATTGCTCAGGTTCGAAC
AAAAGCAAAGGCTGAGAGTGCAGCTCTCCATGCTGGACTCCGCAAAGAGCAGATGAAGGTGGAGTCCCTGGAAAGGGCCCTGCAGCAGAA
GAACCAAGAAATTGAAGAACTGACAAAAATCTGTGATGAGCTGATTGCAAAGCTGGGAAAGACTGACTGAGACACTCCCCCTGTTAGCTC
AACAGATCTGCATTTGGCTGCTTCTCTTGTGACCACAATTATCTTGCCTTATCCAGGAATAATTGCCCCTTTGCAGAGAAAAAAAAAAAC
TTAAAAAAAGCACATGCCTACTGCTGCCTGTCCCGCTTTGCTGCCAATGCAACAGCCCTGGAAGAAACCCTAGAGGGTTGCATAGTCTAG
AAAGGAGTGTGACCTGACAGTGCTGGAGCCTCCTAGTTTCCCCCTATGAAGGTTCCCTTAGGCTGCTGAGTTTGGGTTTGTGATTTATCT
TTAGTTTGTTTTAAAGTCATCTTTACTTTCCCAAATGTGTTAAATTTGTAACTCCTCTTTGGGGTCTTCTCCACCACCTGTCTGATTTTT
TTGTGATCTGTTTAATCTTTTAATTTTTTAGTATCAGTGGTTTTATTTAAGGAGACAGTTTGGCCTATTGTTACTTCCAATTTATAATCA
AGAAGGGGCTCTGGATCCCCTTTTAAATTACACACACTCTCACACACATACATGTATGTTTATAGATGCTGCTGCTCTTTTCCCTGAAGC
ATAGTCAAGTAAGAACTGCTCTACAGAAGGACATATTTCCTTGGATGTGAGACCCTATTTTGAAATAGAGTCCTGACTCAGAACACCAAC
TTAAGAATTTGGGGGATTAAAGATGTGAAGACCACAGTCTTGGGTTTTCATATCTGGAGAAGACTATTTGCCATGACGTTTTGTTGCCCT
GGTATTTGGACACTCCTCAGCTTTAATGGGTGTGGCCCCTTTAGGGTTAGTCCTCAGACTAATGATAGTGTCTGCTTTCTGCATGAACGG
CAATATGGGACTCCCTCCAAGCTAGGGTTTGGCAAGTCTGCCCTAGAGTCATTTACTCTCCTCTGCCTCCATTTGTTAATACAGAATCAA
CATTTAGTCTTCATTATCTTTTTTTTTTTTTTTGAGACAGAGTTTCGATCTATTTTAAGTATGTGAAGAAAATCTACTTGTAAAAGGCTC
AGATCTTAATTAAAAGGTAATTGTAGCACATTACCAATTATAAGGTGAAGAAATGTTTTTTTCCCAAGTGTGATGCATTGTTCTTCAGAT
GTTGAAAAGAAAGCAAAAAATACCTTCTAACTTAAGACAGAATTTTTAACAAAATGAGCAGTAAAAGTCACATGAACCACTCCAAAAATC
AGTGCATTTTGCATATTTTTAAACAAAGACAGCTTGTTGAATACTGAGAAGAGGAGTGCAAGGAGAAGGTCTGTACTAACAAAGCCAAAT
TCCTCAAGCTCTTACTGGACTCAGTTCAGAGTGGTGGGCCATTAACCCCAACATGGAATTTTTCCATATAAATCTCAATGAATTCCCTTT
CATTTGAATAGGCAAACCCAAATCCATGCAAGTGTTTTAAAGCACTGTCCTGTCTTAATCTTACATGCTGAAAGTCTTCATGGTGATATG
CACTATATTCAGTATACGTATGTTTTCCTACTTCTCTTGTAAAACTGTTGCATGATCCAACTTCAGCAATGAATTGTGCCTAGTGGAGAA
CCTCTATAGATCTTAAAAAATGAATTATTCTTTAGCAGTGTATTACTCACATGGGTGCAATCTTTAGCCCCAGGGAGGTCAATAATGTCT
TTTAAAGCCAGAAGTCACATTTTACCAATATGCATTTATCATAATTGGTGCTTAGGCTGTATATTCAAGCCTGTTGTCTTAACATTTTGT
ATAAAAAAGAACAACAGAAATTATCTGTCATTTGAGAAGTGGCTTGACAATCATTTGAGCTTTGAAAGCAGTCACTGTGGTGTAATATGA
ATGCTGTCCTAGTGGTCATAGTACCAAGGGCACGTGTCTCCCCTTGGTATAACTGATTTCCTTTTTAGTCCTCTACTGCTAAATAAGTTA
ATTTTGCATTTTGCAGAAAGAAACATTGATTGCTAAATCTTTTTGCTGCTGTGTTTTGGTGTTTTCATGTTTACTTGTTTTATATTGATC
TGTTTTAAGTATGAGAGGCTTATAGTGCCCTCCATTGTAAATCCATAGTCATCTTTTTAAGCTTATTGTGTTTAAGAAAGTAGCTATGTG
TTAAACAGAGGTGATGGCAGCCCTTCCCTAGCACACTGGTGGAAGAGACCCCTTAAGAACCTGACCCCAGTGAATGAAGCTGATGCACAG
GGAGCACCAAAGGACCTTCGTTAAGTGATAATTGTCCTGGCCTCTCAGCCATGACCGTTATGAGGAAATATCCCCCATTCGAACTTAACA
GATGCCTCCTCTCCAAAGAGAATTAAAATCGTAGCTTGTACAGATCAAGAGAATATACTGGGCAGAATGAAGTATGTTTGTTTATTTTTC
TTTAAAAATAAAGGATTTTGGAACTCTGGAGAGTAAGAATATAGTATAGAGTTTGCCTCAACACATGTGAGGGCCAAATAACCTGCTAGC
TAGGCAGTAATAAACTCTGTTACAGAAGAGAAAAAGGGCCGGGCACAGTGGCTTATTCCTGTAATCCCAACACTGTGGAAGGCCGAGGCA
GGAGGATCACTTGAGTCCAGGAGTTTGAAACCTACCTAGGCAACATGGTGAAACCTTGTCTCTACCAAAATAAAAATTAGCTGGGCATGG
TGGCACGTGCCTGTGGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGCCTGGGAGGTCAAGGCTGCAGTGAGCCATGATCATGCCACTGCA

>96965_96965_3_UQCC1-TACC1_UQCC1_chr20_33934967_ENST00000374377_TACC1_chr8_38682826_ENST00000519416_length(amino acids)=350AA_BP=10
MFSSAAESWGGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTIN
HAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEV
LEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQ

--------------------------------------------------------------
>96965_96965_4_UQCC1-TACC1_UQCC1_chr20_33934967_ENST00000374377_TACC1_chr8_38682826_ENST00000520340_length(transcript)=867nt_BP=306nt
ATTGAGGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGT
GTCTCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGGGTGTCAGATGCCTGATACATTCAATTCATGGTTTCTTATA
ACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCATTTTATG
TGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGAGTGGCTGTAAGGTGAAGAAGCATGAAACTCAGTCTCTCGCCCTGGATGCATG
TTCTCGGGATGAAGGGGCAGTGATCTCCCAGATTTCAGACATTTCTAATAGGGATGGCCATGCTACTGATGAGGAGAAACTGGCATCCAC
GTCATGTGGTCAGAAATCAGCTGGTGCCGAGGTGAAAGGCATAGAGAAGGAGACGTGCCAGAAGATGGAAGAAGACGGGTCCACTGTGCT
TGGGCTGCTGGAGTCCTCTGCAGAGAAGGCCCCTGTGTCGGTGTCCTGTGGAGGTGAGAGCCCCCTGGATGGGATCTGCCTCAGCGAATC
AGACAAGACAGCCGTGCTCACCTTAATAAGAGAAGAGATAATTACTAAAGAGATTGAAGCAAATGAATGGAAGAAGAAATACGAAGAGAC
CCGGCAAGAAGTTTTGGAGATGAGAAAGGAGAGTTATGAGCCATGAAATGACTAAAGATGAAATCAAAGTAGAGAAGAAAAAAAGGCATA

>96965_96965_4_UQCC1-TACC1_UQCC1_chr20_33934967_ENST00000374377_TACC1_chr8_38682826_ENST00000520340_length(amino acids)=162AA_BP=10
MFSSAAESWGSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGIEKETCQKMEEDGSTVLGL

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>96965_96965_5_UQCC1-TACC1_UQCC1_chr20_33934967_ENST00000374377_TACC1_chr8_38682826_ENST00000520615_length(transcript)=4103nt_BP=306nt
ATTGAGGAACATGGCGTTGCTGGTGCGAGTCCTTAGGAACCAGACTAGCATTTCTCAGTGGGTTCCAGTATGCAGCCGATTGATACCTGT
GTCTCCTACCCAAGGACAGGGGGACAGGGCTCTGTCTCGCACTTCCCAGGGTGTCAGATGCCTGATACATTCAATTCATGGTTTCTTATA
ACCCTACTCCACGTCTGGATGTGTCTAGTCCGAATGAAGCAGGAAGGCCGGAGTGGGAAGTACATGTGTCGTATCATAGTTCATTTTATG
TGGGAGGATGTTCAGCAGCGCGGCAGAGTCATGGGGGAGTGGCTGTAAGGTGAAGAAGCATGAAACTCAGTCTCTCGCCCTGGATGCATG
TTCTCGGGATGAAGGGGCAGTGATCTCCCAGATTTCAGACATTTCTAATAGGGATGGCCATGCTACTGATGAGGAGAAACTGGCATCCAC
GTCATGTGGTCAGAAATCAGCTGGTGCCGAGGTGAAAGGTGAGCCAGAGGAAGACCTGGAGTACTTTGAATGTTCCAATGTTCCTGTGTC
TACCATAAATCATGCGTTTTCATCCTCAGAAGCAGGCATAGAGAAGGAGACGTGCCAGAAGATGGAAGAAGACGGGTCCACTGTGCTTGG
GCTGCTGGAGTCCTCTGCAGAGAAGGCCCCTGTGTCGGTGTCCTGTGGAGGTGAGAGCCCCCTGGATGGGATCTGCCTCAGCGAATCAGA
CAAGACAGCCGTGCTCACCTTAATAAGAGAAGAGATAATTACTAAAGAGATTGAAGCAAATGAATGGAAGAAGAAATACGAAGAGACCCG
GCAAGAAGTTTTGGAGATGAGGAAAATTGTAGCTGAATATGAAAAGACTATTGCTCAAATGATTGAAGATGAACAAAGGACAAGTATGAC
CTCTCAGAAGAGCTTCCAGCAACTGACCATGGAGAAGGAACAGGCCCTGGCTGACCTTAACTCTGTGGAAAGGTCCCTTTCTGATCTCTT
CAGGAGATATGAGAACCTGAAAGGTGTTCTGGAAGGGTTCAAGAAGAATGAAGAAGCCTTGAAGAAATGTGCTCAGGATTACTTAGCCAG
AGTTAAACAAGAGGAGCAGCGATACCAGGCCCTGAAAATCCACGCAGAAGAGAAACTGGACAAAGCCAATGAAGAGATTGCTCAGGTTCG
AACAAAAGCAAAGGCTGAGAGTGCAGCTCTCCATGCTGGACTCCGCAAAGAGCAGATGAAGGTGGAGTCCCTGGAAAGGGCCCTGCAGCA
GAAGAACCAAGAAATTGAAGAACTGACAAAAATCTGTGATGAGCTGATTGCAAAGCTGGGAAAGACTGACTGAGACACTCCCCCTGTTAG
CTCAACAGATCTGCATTTGGCTGCTTCTCTTGTGACCACAATTATCTTGCCTTATCCAGGAATAATTGCCCCTTTGCAGAGAAAAAAAAA
AACTTAAAAAAAGCACATGCCTACTGCTGCCTGTCCCGCTTTGCTGCCAATGCAACAGCCCTGGAAGAAACCCTAGAGGGTTGCATAGTC
TAGAAAGGAGTGTGACCTGACAGTGCTGGAGCCTCCTAGTTTCCCCCTATGAAGGTTCCCTTAGGCTGCTGAGTTTGGGTTTGTGATTTA
TCTTTAGTTTGTTTTAAAGTCATCTTTACTTTCCCAAATGTGTTAAATTTGTAACTCCTCTTTGGGGTCTTCTCCACCACCTGTCTGATT
TTTTTGTGATCTGTTTAATCTTTTAATTTTTTAGTATCAGTGGTTTTATTTAAGGAGACAGTTTGGCCTATTGTTACTTCCAATTTATAA
TCAAGAAGGGGCTCTGGATCCCCTTTTAAATTACACACACTCTCACACACATACATGTATGTTTATAGATGCTGCTGCTCTTTTCCCTGA
AGCATAGTCAAGTAAGAACTGCTCTACAGAAGGACATATTTCCTTGGATGTGAGACCCTATTTTGAAATAGAGTCCTGACTCAGAACACC
AACTTAAGAATTTGGGGGATTAAAGATGTGAAGACCACAGTCTTGGGTTTTCATATCTGGAGAAGACTATTTGCCATGACGTTTTGTTGC
CCTGGTATTTGGACACTCCTCAGCTTTAATGGGTGTGGCCCCTTTAGGGTTAGTCCTCAGACTAATGATAGTGTCTGCTTTCTGCATGAA
CGGCAATATGGGACTCCCTCCAAGCTAGGGTTTGGCAAGTCTGCCCTAGAGTCATTTACTCTCCTCTGCCTCCATTTGTTAATACAGAAT
CAACATTTAGTCTTCATTATCTTTTTTTTTTTTTTTGAGACAGAGTTTCGATCTATTTTAAGTATGTGAAGAAAATCTACTTGTAAAAGG
CTCAGATCTTAATTAAAAGGTAATTGTAGCACATTACCAATTATAAGGTGAAGAAATGTTTTTTTCCCAAGTGTGATGCATTGTTCTTCA
GATGTTGAAAAGAAAGCAAAAAATACCTTCTAACTTAAGACAGAATTTTTAACAAAATGAGCAGTAAAAGTCACATGAACCACTCCAAAA
ATCAGTGCATTTTGCATATTTTTAAACAAAGACAGCTTGTTGAATACTGAGAAGAGGAGTGCAAGGAGAAGGTCTGTACTAACAAAGCCA
AATTCCTCAAGCTCTTACTGGACTCAGTTCAGAGTGGTGGGCCATTAACCCCAACATGGAATTTTTCCATATAAATCTCAATGAATTCCC
TTTCATTTGAATAGGCAAACCCAAATCCATGCAAGTGTTTTAAAGCACTGTCCTGTCTTAATCTTACATGCTGAAAGTCTTCATGGTGAT
ATGCACTATATTCAGTATACGTATGTTTTCCTACTTCTCTTGTAAAACTGTTGCATGATCCAACTTCAGCAATGAATTGTGCCTAGTGGA
GAACCTCTATAGATCTTAAAAAATGAATTATTCTTTAGCAGTGTATTACTCACATGGGTGCAATCTTTAGCCCCAGGGAGGTCAATAATG
TCTTTTAAAGCCAGAAGTCACATTTTACCAATATGCATTTATCATAATTGGTGCTTAGGCTGTATATTCAAGCCTGTTGTCTTAACATTT
TGTATAAAAAAGAACAACAGAAATTATCTGTCATTTGAGAAGTGGCTTGACAATCATTTGAGCTTTGAAAGCAGTCACTGTGGTGTAATA
TGAATGCTGTCCTAGTGGTCATAGTACCAAGGGCACGTGTCTCCCCTTGGTATAACTGATTTCCTTTTTAGTCCTCTACTGCTAAATAAG
TTAATTTTGCATTTTGCAGAAAGAAACATTGATTGCTAAATCTTTTTGCTGCTGTGTTTTGGTGTTTTCATGTTTACTTGTTTTATATTG
ATCTGTTTTAAGTATGAGAGGCTTATAGTGCCCTCCATTGTAAATCCATAGTCATCTTTTTAAGCTTATTGTGTTTAAGAAAGTAGCTAT
GTGTTAAACAGAGGTGATGGCAGCCCTTCCCTAGCACACTGGTGGAAGAGACCCCTTAAGAACCTGACCCCAGTGAATGAAGCTGATGCA
CAGGGAGCACCAAAGGACCTTCGTTAAGTGATAATTGTCCTGGCCTCTCAGCCATGACCGTTATGAGGAAATATCCCCCATTCGAACTTA
ACAGATGCCTCCTCTCCAAAGAGAATTAAAATCGTAGCTTGTACAGATCAAGAGAATATACTGGGCAGAATGAAGTATGTTTGTTTATTT
TTCTTTAAAAATAAAGGATTTTGGAACTCTGGAGAGTAAGAATATAGTATAGAGTTTGCCTCAACACATGTGAGGGCCAAATAACCTGCT
AGCTAGGCAGTAATAAACTCTGTTACAGAAGAGAAAAAGGGCCGGGCACAGTGGCTTATTCCTGTAATCCCAACACTGTGGAAGGCCGAG
GCAGGAGGATCACTTGAGTCCAGGAGTTTGAAACCTACCTAGGCAACATGGTGAAACCTTGTCTCTACCAAAATAAAAATTAGCTGGGCA
TGGTGGCACGTGCCTGTGGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGCCTGGGAGGTCAAGGCTGCAGTGAGCCATGATCATGCCACT

>96965_96965_5_UQCC1-TACC1_UQCC1_chr20_33934967_ENST00000374377_TACC1_chr8_38682826_ENST00000520615_length(amino acids)=351AA_BP=10
MFSSAAESWGSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTI
NHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQE
VLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVK

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Fusion Gene PPI Analysis for UQCC1-TACC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTACC1chr20:33934967chr8:38682826ENST00000276520011701_80553.666666666666664396.0CH-TOG
TgeneTACC1chr20:33934967chr8:38682826ENST00000317827213701_805463.6666666666667806.0CH-TOG
TgeneTACC1chr20:33934967chr8:38682826ENST00000330691112701_80537.666666666666664380.0CH-TOG
TgeneTACC1chr20:33934967chr8:38682826ENST00000348567011701_80525.666666666666668368.0CH-TOG
TgeneTACC1chr20:33934967chr8:38682826ENST00000379931314701_805475.6666666666667818.0CH-TOG
TgeneTACC1chr20:33934967chr8:38682826ENST00000518415415701_805418.6666666666667732.0CH-TOG
TgeneTACC1chr20:33934967chr8:38682826ENST00000520615213701_805268.6666666666667611.0CH-TOG
TgeneTACC1chr20:33934967chr8:38682826ENST00000276520011152_25953.666666666666664396.0TDRD7
TgeneTACC1chr20:33934967chr8:38682826ENST00000330691112152_25937.666666666666664380.0TDRD7
TgeneTACC1chr20:33934967chr8:38682826ENST00000348567011152_25925.666666666666668368.0TDRD7
TgeneTACC1chr20:33934967chr8:38682826ENST00000276520011206_42753.666666666666664396.0YEATS4
TgeneTACC1chr20:33934967chr8:38682826ENST00000330691112206_42737.666666666666664380.0YEATS4
TgeneTACC1chr20:33934967chr8:38682826ENST00000348567011206_42725.666666666666668368.0YEATS4


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTACC1chr20:33934967chr8:38682826ENST000002765200112_5553.666666666666664396.0LSM7 and SNRPG
TgeneTACC1chr20:33934967chr8:38682826ENST000003178272132_55463.6666666666667806.0LSM7 and SNRPG
TgeneTACC1chr20:33934967chr8:38682826ENST000003306911122_5537.666666666666664380.0LSM7 and SNRPG
TgeneTACC1chr20:33934967chr8:38682826ENST000003485670112_5525.666666666666668368.0LSM7 and SNRPG
TgeneTACC1chr20:33934967chr8:38682826ENST000003799313142_55475.6666666666667818.0LSM7 and SNRPG
TgeneTACC1chr20:33934967chr8:38682826ENST000005184154152_55418.6666666666667732.0LSM7 and SNRPG
TgeneTACC1chr20:33934967chr8:38682826ENST000005206152132_55268.6666666666667611.0LSM7 and SNRPG
TgeneTACC1chr20:33934967chr8:38682826ENST00000317827213152_259463.6666666666667806.0TDRD7
TgeneTACC1chr20:33934967chr8:38682826ENST00000379931314152_259475.6666666666667818.0TDRD7
TgeneTACC1chr20:33934967chr8:38682826ENST00000518415415152_259418.6666666666667732.0TDRD7
TgeneTACC1chr20:33934967chr8:38682826ENST00000520615213152_259268.6666666666667611.0TDRD7
TgeneTACC1chr20:33934967chr8:38682826ENST00000317827213206_427463.6666666666667806.0YEATS4
TgeneTACC1chr20:33934967chr8:38682826ENST00000379931314206_427475.6666666666667818.0YEATS4
TgeneTACC1chr20:33934967chr8:38682826ENST00000518415415206_427418.6666666666667732.0YEATS4
TgeneTACC1chr20:33934967chr8:38682826ENST00000520615213206_427268.6666666666667611.0YEATS4


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for UQCC1-TACC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for UQCC1-TACC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource