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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BICD2-ASPN (FusionGDB2 ID:9705)

Fusion Gene Summary for BICD2-ASPN

Fusion gene summary

Fusion gene information	Fusion gene name: BICD2-ASPN
	Fusion gene ID: 9705
		Hgene	Tgene
	Gene symbol	BICD2	ASPN
	Gene ID	23299	54829
	Gene name	BICD cargo adaptor 2	asporin
	Synonyms	SMALED2\|SMALED2A\|SMALED2B\|bA526D8.1	OS3\|PLAP-1\|PLAP1\|SLRR1C
	Cytomap	9q22.31	9q22.31
	Type of gene	protein-coding	protein-coding
	Description	protein bicaudal D homolog 2bic-D 2bicaudal D homolog 2coiled-coil protein BICD2cytoskeleton-like bicaudal D protein homolog 2homolog of Drosophila bicaudal D	asporinasporin (LRR class 1)asporin proteoglycanperiodontal ligament associated protein 1small leucine-rich protein 1C
	Modification date	20200313	20200313
	UniProtAcc	Q8TD16	Q9BXN1
	Ensembl transtripts involved in fusion gene	ENST00000375512, ENST00000356884,	ENST00000450139, ENST00000375543, ENST00000375544, ENST00000395538,
Fusion gene scores	* DoF score	6 X 5 X 4=120	3 X 2 X 3=18
	# samples	6	4
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: BICD2 [Title/Abstract] AND ASPN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BICD2(95477535)-ASPN(95228853), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ASPN	GO:0030282	bone mineralization	19589127
Tgene	ASPN	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	17827158

Fusion gene breakpoints across BICD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ASPN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CV-7414-01A	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-

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Fusion Gene ORF analysis for BICD2-ASPN

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000375512	ENST00000450139	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-
In-frame	ENST00000375512	ENST00000375543	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-
In-frame	ENST00000375512	ENST00000375544	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-
In-frame	ENST00000375512	ENST00000395538	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-
intron-3CDS	ENST00000356884	ENST00000375543	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-
intron-3CDS	ENST00000356884	ENST00000375544	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-
intron-3CDS	ENST00000356884	ENST00000395538	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-
intron-intron	ENST00000356884	ENST00000450139	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375512	BICD2	chr9	95477535	-	ENST00000375543	ASPN	chr9	95228853	-	4143	2537	26	2881	951
ENST00000375512	BICD2	chr9	95477535	-	ENST00000375544	ASPN	chr9	95228853	-	4376	2537	26	3292	1088
ENST00000375512	BICD2	chr9	95477535	-	ENST00000395538	ASPN	chr9	95228853	-	2879	2537	26	2878	951

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375512	ENST00000375543	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-	0.005265533	0.9947345
ENST00000375512	ENST00000375544	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-	0.002255063	0.9977449
ENST00000375512	ENST00000395538	BICD2	chr9	95477535	-	ASPN	chr9	95228853	-	0.30110925	0.69889075

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Fusion Genomic Features for BICD2-ASPN

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BICD2-ASPN

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:95477535/chr9:95228853)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BICD2 Q8TD16	ASPN Q9BXN1
FUNCTION: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity). {ECO:0000250\|UniProtKB:Q921C5, ECO:0000269\|PubMed:25962623}.	FUNCTION: Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. {ECO:0000250, ECO:0000269\|PubMed:17827158, ECO:0000269\|PubMed:19589127}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BICD2

chr9:95477535

chr9:95228853

ENST00000375512

20_269

823

825.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BICD2

chr9:95477535

chr9:95228853

ENST00000375512

338_537

823

825.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BICD2

chr9:95477535

chr9:95228853

ENST00000375512

666_808

823

825.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BICD2

chr9:95477535

chr9:95228853

ENST00000375512

25_398

823

825.0

Region

Interacts with DYNLL1%2C DYNC1H1%2C DYNC1I2%2C DCTN1 and DCTN2

Hgene

BICD2

chr9:95477535

chr9:95228853

ENST00000375512

666_814

823

825.0

Region

Interacts with RAB6A

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

127_148

129

381.0

Repeat

Note=LRR 2

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

151_173

129

381.0

Repeat

Note=LRR 3

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

174_193

129

381.0

Repeat

Note=LRR 4

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

196_219

129

381.0

Repeat

Note=LRR 5

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

242_263

129

381.0

Repeat

Note=LRR 6

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

266_287

129

381.0

Repeat

Note=LRR 7

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

290_312

129

381.0

Repeat

Note=LRR 8

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

313_334

129

381.0

Repeat

Note=LRR 9

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

335_357

129

381.0

Repeat

Note=LRR 10

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

358_380

129

381.0

Repeat

Note=LRR 11

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BICD2

chr9:95477535

chr9:95228853

ENST00000356884

20_269

856.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BICD2

chr9:95477535

chr9:95228853

ENST00000356884

338_537

856.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BICD2

chr9:95477535

chr9:95228853

ENST00000356884

666_808

856.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BICD2

chr9:95477535

chr9:95228853

ENST00000356884

25_398

856.0

Region

Interacts with DYNLL1%2C DYNC1H1%2C DYNC1I2%2C DCTN1 and DCTN2

Hgene

BICD2

chr9:95477535

chr9:95228853

ENST00000356884

666_814

856.0

Region

Interacts with RAB6A

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

35_53

129

381.0

Compositional bias

Note=Poly-Asp

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

75_88

129

381.0

Compositional bias

Note=Cys-rich

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

66_102

129

381.0

Domain

Note=LRRNT

Tgene

ASPN

chr9:95477535

chr9:95228853

ENST00000375544

103_124

129

381.0

Repeat

Note=LRR 1

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Fusion Gene Sequence for BICD2-ASPN

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>9705_9705_1_BICD2-ASPN_BICD2_chr9_95477535_ENST00000375512_ASPN_chr9_95228853_ENST00000375543_length(transcript)=4143nt_BP=2537nt
GCGGCGGCGGCTGAGGAGGGCCCGGCCTGCGAGAGCCTCAGTGGGAGCCGGCTCAGCCCTCGGCCACCATGTCGGCGCCGTCGGAGGAGG
AGGAGTACGCGCGGCTGGTGATGGAGGCGCAGCCGGAGTGGCTGCGCGCCGAGGTGAAGCGGCTGTCCCACGAGCTGGCCGAGACCACGC
GTGAGAAGATCCAGGCGGCCGAGTACGGGCTGGCGGTGCTCGAGGAGAAGCACCAGCTCAAGCTGCAGTTCGAGGAGCTCGAGGTGGACT
ATGAGGCTATCCGCAGCGAGATGGAGCAGCTCAAGGAGGCCTTTGGACAAGCACACACAAACCACAAGAAGGTGGCTGCTGACGGAGAGA
GCCGGGAGGAGAGCCTGATCCAGGAGTCGGCCTCCAAGGAGCAGTACTACGTGCGGAAGGTGCTAGAGCTGCAGACGGAGCTGAAGCAGT
TGCGCAATGTCCTCACCAACACGCAGTCGGAGAATGAGCGCCTGGCCTCTGTGGCCCAGGAGCTGAAGGAGATCAACCAGAATGTGGAGA
TCCAGCGTGGCCGCCTGCGGGATGACATCAAGGAGTACAAATTCCGGGAAGCTCGTCTGCTGCAGGACTACTCGGAACTGGAGGAGGAGA
ACATCAGCCTGCAGAAGCAAGTGTCTGTGCTCAGACAGAACCAGGTGGAGTTTGAGGGCCTCAAGCATGAGATCAAGCGTCTGGAGGAGG
AGACCGAGTACCTCAACAGCCAGCTGGAGGATGCCATCCGCCTCAAGGAGATCTCAGAGCGGCAGCTGGAGGAGGCGCTGGAGACCCTGA
AGACGGAGCGCGAACAGAAGAACAGCCTGCGCAAGGAGCTGTCACACTACATGAGCATCAATGACTCCTTCTACACCAGCCACCTGCATG
TCTCGCTGGATGGCCTCAAGTTCAGTGACGATGCTGCCGAGCCCAACAACGATGCCGAGGCCCTGGTCAATGGCTTTGAGCACGGCGGCC
TGGCCAAGCTGCCACTGGACAACAAGACCTCCACGCCCAAGAAGGAGGGCCTCGCACCGCCCTCCCCCAGCCTCGTCTCCGACCTACTCA
GTGAGCTCAACATCTCTGAGATCCAGAAGCTGAAGCAGCAGCTGATGCAGATGGAGCGGGAAAAGGCGGGCCTGCTGGCAACGCTGCAGG
ACACACAGAAGCAGCTGGAGCACACGCGGGGCTCCCTGTCAGAACAGCAGGAGAAGGTGACCCGCCTCACAGAGAATCTGAGTGCCCTGC
GGCGCCTGCAGGCCAGCAAGGAGCGGCAGACAGCCCTGGACAACGAGAAGGACCGTGACAGCCATGAGGATGGGGACTACTACGAGGTGG
ACATCAACGGGCCTGAGATCTTGGCCTGCAAGTACCATGTGGCTGTGGCTGAGGCTGGCGAGCTCCGCGAGCAGCTCAAGGCACTGCGCA
GCACGCACGAGGCTCGTGAGGCCCAGCACGCCGAGGAGAAGGGCCGCTATGAGGCTGAGGGCCAGGCACTCACGGAGAAGGTCTCCCTGC
TAGAGAAGGCCAGCCGCCAGGACCGCGAGCTGCTGGCCCGGCTGGAGAAGGAGCTAAAGAAGGTGAGCGACGTCGCCGGCGAGACACAGG
GCAGCCTGAGTGTGGCCCAGGATGAGCTGGTGACCTTCAGTGAGGAGCTGGCCAATCTCTACCACCACGTGTGCATGTGCAACAATGAGA
CACCCAACCGTGTCATGCTGGACTACTACCGCGAGGGCCAGGGCGGGGCCGGCCGCACCAGTCCCGGGGGCCGCACCAGCCCCGAGGCGC
GTGGCCGGCGCTCACCCATCCTCCTACCCAAGGGGCTGCTGGCTCCTGAGGCGGGCCGAGCAGATGGTGGGACGGGGGACAGCAGCCCCT
CGCCTGGCTCCTCACTGCCATCACCCCTGAGTGACCCACGCCGGGAGCCCATGAACATCTACAACCTGATCGCTATCATCCGTGACCAGA
TCAAGCACCTGCAGGCAGCCGTGGACCGCACCACGGAGCTGTCACGCCAGCGCATTGCCTCTCAGGAGCTGGGCCCCGCCGTGGACAAGG
ACAAGGAAGCGCTTATGGAGGAGATCCTCAAGCTGAAGTCGCTGCTCAGCACCAAGCGGGAGCAGATCACCACGCTGCGCACTGTGCTCA
AGGCCAACAAGCAGACGGCCGAGGTGGCCCTTGCCAACCTGAAGAGCAAGTATGAGAATGAGAAGGCCATGGTTACCGAGACCATGATGA
AGCTGCGCAATGAGCTCAAGGCCCTCAAGGAGGACGCAGCCACCTTCTCCTCGCTGCGTGCTATGTTTGCCACCAGGTGTGACGAGTACA
TTACACAGCTGGATGAGATGCAGCGGCAGCTGGCGGCTGCTGAGGACGAGAAGAAGACGCTGAACTCGCTGCTGCGCATGGCCATCCAGC
AGAAGCTGGCGCTGACCCAGCGGCTGGAGCTGCTCGAGCTGGACCATGAGCAGACCCGGCGTGGCCGTGCCAAAGCCGCCCCGAAGACCA
AGCCAGCCACACCGAGCGGTCTGATCCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTTCTAACCACAAAGAAGTTGCGAA
GGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAACTCAGAATTCATGAAAATAAAGTTA
AGAAAATACAAAAGGACACATTCAAAGGAATGAATGCTTTACACGTTTTGGAAATGAGTGCAAACCCTCTTGATAATAATGGGATAGAGC
CAGGGGCATTTGAAGGGGTGACGGTGTTCCATATCAGAATTGCAGAAGCAAAACTGACCTCAGTTCCTAAAGATAATCTTCCTTCATTCT
AATTCAATTGCAAGAGTGGGAGTAAATGACTTCTGTCCAACAGTGCCAAAGATGAAGAAATCTTTATACAGTGCAATAAGTTTATTCAAC
AACCCGGTGAAATACTGGGAAATGCAACCTGCAACATTTCGTTGTGTTTTGAGCAGAATGAGCGTTCAGCTTGGGAACTTTGGAATGTAA
TAATTAGTAATTGGTAATGTCCATTTAATATAAGATTCAAAAATCCCTACATTTGGAATACTTGAACTCTATTAATAATGGTAGTATTAT
ATATACAAGCAAATATCTATTCTCAAGTGGTAAGTCCACTGACTTATTTTATGACAAGAAATTTCAACGGAATTTTGCCAAACTATTGAT
ACATAAGGGTTGAGAGAAACAAGCATCTATTGCAGTTTCTTTTTGCGTACAAATGATCTTACATAAATCTCATGCTTGACCATTCCTTTC
TTCATAACAAAAAAGTAAGATATTCGGTATTTAACACTTTGTTATCAAGCATATTTTAAAAAGAACTGTACTGTAAATGGAATGCTTGAC
TTAGCAAAATTTGTGCTCTTTCATTTGCTGTTAGAAAAACAGAATTAACAAAGACAGTAATGTGAAGAGTGCATTACACTATTCTTATTC
TTTAGTAACTTGGGTAGTACTGTAATATTTTTAATCATCTTAAAGTATGATTTGATATAATCTTATTGAAATTACCTTATCATGTCTTAG
AGCCCGTCTTTATGTTTAAAACTAATTTCTTAAAATAAAGCCTTCAGTAAATGTTCATTACCAACTTGATAAATGCTACTCATAAGAGCT
GGTTTGGGGCTATAGCATATGCTTTTTTTTTTTTAATTATTACCTGATTTAAAAATCTCTGTAAAAACGTGTAGTGTTTCATAAAATCTG
TAACTCGCATTTTAATGATCCGCTATTATAAGCTTTTAATAGCATGAAAATTGTTAGGCTATATAACATTGCCACTTCAACTCTAAGGAA
TATTTTTGAGATATCCCTTTGGAAGACCTTGCTTGGAAGAGCCTGGACACTAACAATTCTACACCAAATTGTCTCTTCAAATACGTATGG
ACTGGATAACTCTGAGAAACACATCTAGTATAACTGAATAAGCAGAGCATCAAATTAAACAGACAGAAACCGAAAGCTCTATATAAATGC
TCAGAGTTCTTTATGTATTTCTTATTGGCATTCAACATATGTAAAATCAGAAAACAGGGAAATTTTCATTAAAAATATTGGTTTGAAATA

>9705_9705_1_BICD2-ASPN_BICD2_chr9_95477535_ENST00000375512_ASPN_chr9_95228853_ENST00000375543_length(amino acids)=951AA_BP=1
MREPQWEPAQPSATMSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEME
QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDD
IKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNS
LRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQ
KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILA
CKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE
LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP
LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEV
ALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRL
ELLELDHEQTRRGRAKAAPKTKPATPSGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFK

--------------------------------------------------------------
>9705_9705_2_BICD2-ASPN_BICD2_chr9_95477535_ENST00000375512_ASPN_chr9_95228853_ENST00000375544_length(transcript)=4376nt_BP=2537nt
GCGGCGGCGGCTGAGGAGGGCCCGGCCTGCGAGAGCCTCAGTGGGAGCCGGCTCAGCCCTCGGCCACCATGTCGGCGCCGTCGGAGGAGG
AGGAGTACGCGCGGCTGGTGATGGAGGCGCAGCCGGAGTGGCTGCGCGCCGAGGTGAAGCGGCTGTCCCACGAGCTGGCCGAGACCACGC
GTGAGAAGATCCAGGCGGCCGAGTACGGGCTGGCGGTGCTCGAGGAGAAGCACCAGCTCAAGCTGCAGTTCGAGGAGCTCGAGGTGGACT
ATGAGGCTATCCGCAGCGAGATGGAGCAGCTCAAGGAGGCCTTTGGACAAGCACACACAAACCACAAGAAGGTGGCTGCTGACGGAGAGA
GCCGGGAGGAGAGCCTGATCCAGGAGTCGGCCTCCAAGGAGCAGTACTACGTGCGGAAGGTGCTAGAGCTGCAGACGGAGCTGAAGCAGT
TGCGCAATGTCCTCACCAACACGCAGTCGGAGAATGAGCGCCTGGCCTCTGTGGCCCAGGAGCTGAAGGAGATCAACCAGAATGTGGAGA
TCCAGCGTGGCCGCCTGCGGGATGACATCAAGGAGTACAAATTCCGGGAAGCTCGTCTGCTGCAGGACTACTCGGAACTGGAGGAGGAGA
ACATCAGCCTGCAGAAGCAAGTGTCTGTGCTCAGACAGAACCAGGTGGAGTTTGAGGGCCTCAAGCATGAGATCAAGCGTCTGGAGGAGG
AGACCGAGTACCTCAACAGCCAGCTGGAGGATGCCATCCGCCTCAAGGAGATCTCAGAGCGGCAGCTGGAGGAGGCGCTGGAGACCCTGA
AGACGGAGCGCGAACAGAAGAACAGCCTGCGCAAGGAGCTGTCACACTACATGAGCATCAATGACTCCTTCTACACCAGCCACCTGCATG
TCTCGCTGGATGGCCTCAAGTTCAGTGACGATGCTGCCGAGCCCAACAACGATGCCGAGGCCCTGGTCAATGGCTTTGAGCACGGCGGCC
TGGCCAAGCTGCCACTGGACAACAAGACCTCCACGCCCAAGAAGGAGGGCCTCGCACCGCCCTCCCCCAGCCTCGTCTCCGACCTACTCA
GTGAGCTCAACATCTCTGAGATCCAGAAGCTGAAGCAGCAGCTGATGCAGATGGAGCGGGAAAAGGCGGGCCTGCTGGCAACGCTGCAGG
ACACACAGAAGCAGCTGGAGCACACGCGGGGCTCCCTGTCAGAACAGCAGGAGAAGGTGACCCGCCTCACAGAGAATCTGAGTGCCCTGC
GGCGCCTGCAGGCCAGCAAGGAGCGGCAGACAGCCCTGGACAACGAGAAGGACCGTGACAGCCATGAGGATGGGGACTACTACGAGGTGG
ACATCAACGGGCCTGAGATCTTGGCCTGCAAGTACCATGTGGCTGTGGCTGAGGCTGGCGAGCTCCGCGAGCAGCTCAAGGCACTGCGCA
GCACGCACGAGGCTCGTGAGGCCCAGCACGCCGAGGAGAAGGGCCGCTATGAGGCTGAGGGCCAGGCACTCACGGAGAAGGTCTCCCTGC
TAGAGAAGGCCAGCCGCCAGGACCGCGAGCTGCTGGCCCGGCTGGAGAAGGAGCTAAAGAAGGTGAGCGACGTCGCCGGCGAGACACAGG
GCAGCCTGAGTGTGGCCCAGGATGAGCTGGTGACCTTCAGTGAGGAGCTGGCCAATCTCTACCACCACGTGTGCATGTGCAACAATGAGA
CACCCAACCGTGTCATGCTGGACTACTACCGCGAGGGCCAGGGCGGGGCCGGCCGCACCAGTCCCGGGGGCCGCACCAGCCCCGAGGCGC
GTGGCCGGCGCTCACCCATCCTCCTACCCAAGGGGCTGCTGGCTCCTGAGGCGGGCCGAGCAGATGGTGGGACGGGGGACAGCAGCCCCT
CGCCTGGCTCCTCACTGCCATCACCCCTGAGTGACCCACGCCGGGAGCCCATGAACATCTACAACCTGATCGCTATCATCCGTGACCAGA
TCAAGCACCTGCAGGCAGCCGTGGACCGCACCACGGAGCTGTCACGCCAGCGCATTGCCTCTCAGGAGCTGGGCCCCGCCGTGGACAAGG
ACAAGGAAGCGCTTATGGAGGAGATCCTCAAGCTGAAGTCGCTGCTCAGCACCAAGCGGGAGCAGATCACCACGCTGCGCACTGTGCTCA
AGGCCAACAAGCAGACGGCCGAGGTGGCCCTTGCCAACCTGAAGAGCAAGTATGAGAATGAGAAGGCCATGGTTACCGAGACCATGATGA
AGCTGCGCAATGAGCTCAAGGCCCTCAAGGAGGACGCAGCCACCTTCTCCTCGCTGCGTGCTATGTTTGCCACCAGGTGTGACGAGTACA
TTACACAGCTGGATGAGATGCAGCGGCAGCTGGCGGCTGCTGAGGACGAGAAGAAGACGCTGAACTCGCTGCTGCGCATGGCCATCCAGC
AGAAGCTGGCGCTGACCCAGCGGCTGGAGCTGCTCGAGCTGGACCATGAGCAGACCCGGCGTGGCCGTGCCAAAGCCGCCCCGAAGACCA
AGCCAGCCACACCGAGCGGTCTGATCCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTTCTAACCACAAAGAAGTTGCGAA
GGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAACTCAGAATTCATGAAAATAAAGTTA
AGAAAATACAAAAGGACACATTCAAAGGAATGAATGCTTTACACGTTTTGGAAATGAGTGCAAACCCTCTTGATAATAATGGGATAGAGC
CAGGGGCATTTGAAGGGGTGACGGTGTTCCATATCAGAATTGCAGAAGCAAAACTGACCTCAGTTCCTAAAGGCTTACCACCAACTTTAT
TGGAGCTTCACTTAGATTATAATAAAATTTCAACAGTGGAACTTGAGGATTTTAAACGATACAAAGAACTACAAAGGCTGGGCCTAGGAA
ACAACAAAATCACAGATATCGAAAATGGGAGTCTTGCTAACATACCACGTGTGAGAGAAATACATTTGGAAAACAATAAACTAAAAAAAA
TCCCTTCAGGATTACCAGAGTTGAAATACCTCCAGATAATCTTCCTTCATTCTAATTCAATTGCAAGAGTGGGAGTAAATGACTTCTGTC
CAACAGTGCCAAAGATGAAGAAATCTTTATACAGTGCAATAAGTTTATTCAACAACCCGGTGAAATACTGGGAAATGCAACCTGCAACAT
TTCGTTGTGTTTTGAGCAGAATGAGCGTTCAGCTTGGGAACTTTGGAATGTAATAATTAGTAATTGGTAATGTCCATTTAATATAAGATT
CAAAAATCCCTACATTTGGAATACTTGAACTCTATTAATAATGGTAGTATTATATATACAAGCAAATATCTATTCTCAAGTGGTAAGTCC
ACTGACTTATTTTATGACAAGAAATTTCAACGGAATTTTGCCAAACTATTGATACATAAGGGTTGAGAGAAACAAGCATCTATTGCAGTT
TCTTTTTGCGTACAAATGATCTTACATAAATCTCATGCTTGACCATTCCTTTCTTCATAACAAAAAAGTAAGATATTCGGTATTTAACAC
TTTGTTATCAAGCATATTTTAAAAAGAACTGTACTGTAAATGGAATGCTTGACTTAGCAAAATTTGTGCTCTTTCATTTGCTGTTAGAAA
AACAGAATTAACAAAGACAGTAATGTGAAGAGTGCATTACACTATTCTTATTCTTTAGTAACTTGGGTAGTACTGTAATATTTTTAATCA
TCTTAAAGTATGATTTGATATAATCTTATTGAAATTACCTTATCATGTCTTAGAGCCCGTCTTTATGTTTAAAACTAATTTCTTAAAATA
AAGCCTTCAGTAAATGTTCATTACCAACTTGATAAATGCTACTCATAAGAGCTGGTTTGGGGCTATAGCATATGCTTTTTTTTTTTTAAT
TATTACCTGATTTAAAAATCTCTGTAAAAACGTGTAGTGTTTCATAAAATCTGTAACTCGCATTTTAATGATCCGCTATTATAAGCTTTT
AATAGCATGAAAATTGTTAGGCTATATAACATTGCCACTTCAACTCTAAGGAATATTTTTGAGATATCCCTTTGGAAGACCTTGCTTGGA
AGAGCCTGGACACTAACAATTCTACACCAAATTGTCTCTTCAAATACGTATGGACTGGATAACTCTGAGAAACACATCTAGTATAACTGA
ATAAGCAGAGCATCAAATTAAACAGACAGAAACCGAAAGCTCTATATAAATGCTCAGAGTTCTTTATGTATTTCTTATTGGCATTCAACA

>9705_9705_2_BICD2-ASPN_BICD2_chr9_95477535_ENST00000375512_ASPN_chr9_95228853_ENST00000375544_length(amino acids)=1088AA_BP=1
MREPQWEPAQPSATMSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEME
QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDD
IKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNS
LRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQ
KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILA
CKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE
LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP
LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEV
ALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRL
ELLELDHEQTRRGRAKAAPKTKPATPSGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFK
GMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIEN
GSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPATFRCVLSRMS

--------------------------------------------------------------
>9705_9705_3_BICD2-ASPN_BICD2_chr9_95477535_ENST00000375512_ASPN_chr9_95228853_ENST00000395538_length(transcript)=2879nt_BP=2537nt
GCGGCGGCGGCTGAGGAGGGCCCGGCCTGCGAGAGCCTCAGTGGGAGCCGGCTCAGCCCTCGGCCACCATGTCGGCGCCGTCGGAGGAGG
AGGAGTACGCGCGGCTGGTGATGGAGGCGCAGCCGGAGTGGCTGCGCGCCGAGGTGAAGCGGCTGTCCCACGAGCTGGCCGAGACCACGC
GTGAGAAGATCCAGGCGGCCGAGTACGGGCTGGCGGTGCTCGAGGAGAAGCACCAGCTCAAGCTGCAGTTCGAGGAGCTCGAGGTGGACT
ATGAGGCTATCCGCAGCGAGATGGAGCAGCTCAAGGAGGCCTTTGGACAAGCACACACAAACCACAAGAAGGTGGCTGCTGACGGAGAGA
GCCGGGAGGAGAGCCTGATCCAGGAGTCGGCCTCCAAGGAGCAGTACTACGTGCGGAAGGTGCTAGAGCTGCAGACGGAGCTGAAGCAGT
TGCGCAATGTCCTCACCAACACGCAGTCGGAGAATGAGCGCCTGGCCTCTGTGGCCCAGGAGCTGAAGGAGATCAACCAGAATGTGGAGA
TCCAGCGTGGCCGCCTGCGGGATGACATCAAGGAGTACAAATTCCGGGAAGCTCGTCTGCTGCAGGACTACTCGGAACTGGAGGAGGAGA
ACATCAGCCTGCAGAAGCAAGTGTCTGTGCTCAGACAGAACCAGGTGGAGTTTGAGGGCCTCAAGCATGAGATCAAGCGTCTGGAGGAGG
AGACCGAGTACCTCAACAGCCAGCTGGAGGATGCCATCCGCCTCAAGGAGATCTCAGAGCGGCAGCTGGAGGAGGCGCTGGAGACCCTGA
AGACGGAGCGCGAACAGAAGAACAGCCTGCGCAAGGAGCTGTCACACTACATGAGCATCAATGACTCCTTCTACACCAGCCACCTGCATG
TCTCGCTGGATGGCCTCAAGTTCAGTGACGATGCTGCCGAGCCCAACAACGATGCCGAGGCCCTGGTCAATGGCTTTGAGCACGGCGGCC
TGGCCAAGCTGCCACTGGACAACAAGACCTCCACGCCCAAGAAGGAGGGCCTCGCACCGCCCTCCCCCAGCCTCGTCTCCGACCTACTCA
GTGAGCTCAACATCTCTGAGATCCAGAAGCTGAAGCAGCAGCTGATGCAGATGGAGCGGGAAAAGGCGGGCCTGCTGGCAACGCTGCAGG
ACACACAGAAGCAGCTGGAGCACACGCGGGGCTCCCTGTCAGAACAGCAGGAGAAGGTGACCCGCCTCACAGAGAATCTGAGTGCCCTGC
GGCGCCTGCAGGCCAGCAAGGAGCGGCAGACAGCCCTGGACAACGAGAAGGACCGTGACAGCCATGAGGATGGGGACTACTACGAGGTGG
ACATCAACGGGCCTGAGATCTTGGCCTGCAAGTACCATGTGGCTGTGGCTGAGGCTGGCGAGCTCCGCGAGCAGCTCAAGGCACTGCGCA
GCACGCACGAGGCTCGTGAGGCCCAGCACGCCGAGGAGAAGGGCCGCTATGAGGCTGAGGGCCAGGCACTCACGGAGAAGGTCTCCCTGC
TAGAGAAGGCCAGCCGCCAGGACCGCGAGCTGCTGGCCCGGCTGGAGAAGGAGCTAAAGAAGGTGAGCGACGTCGCCGGCGAGACACAGG
GCAGCCTGAGTGTGGCCCAGGATGAGCTGGTGACCTTCAGTGAGGAGCTGGCCAATCTCTACCACCACGTGTGCATGTGCAACAATGAGA
CACCCAACCGTGTCATGCTGGACTACTACCGCGAGGGCCAGGGCGGGGCCGGCCGCACCAGTCCCGGGGGCCGCACCAGCCCCGAGGCGC
GTGGCCGGCGCTCACCCATCCTCCTACCCAAGGGGCTGCTGGCTCCTGAGGCGGGCCGAGCAGATGGTGGGACGGGGGACAGCAGCCCCT
CGCCTGGCTCCTCACTGCCATCACCCCTGAGTGACCCACGCCGGGAGCCCATGAACATCTACAACCTGATCGCTATCATCCGTGACCAGA
TCAAGCACCTGCAGGCAGCCGTGGACCGCACCACGGAGCTGTCACGCCAGCGCATTGCCTCTCAGGAGCTGGGCCCCGCCGTGGACAAGG
ACAAGGAAGCGCTTATGGAGGAGATCCTCAAGCTGAAGTCGCTGCTCAGCACCAAGCGGGAGCAGATCACCACGCTGCGCACTGTGCTCA
AGGCCAACAAGCAGACGGCCGAGGTGGCCCTTGCCAACCTGAAGAGCAAGTATGAGAATGAGAAGGCCATGGTTACCGAGACCATGATGA
AGCTGCGCAATGAGCTCAAGGCCCTCAAGGAGGACGCAGCCACCTTCTCCTCGCTGCGTGCTATGTTTGCCACCAGGTGTGACGAGTACA
TTACACAGCTGGATGAGATGCAGCGGCAGCTGGCGGCTGCTGAGGACGAGAAGAAGACGCTGAACTCGCTGCTGCGCATGGCCATCCAGC
AGAAGCTGGCGCTGACCCAGCGGCTGGAGCTGCTCGAGCTGGACCATGAGCAGACCCGGCGTGGCCGTGCCAAAGCCGCCCCGAAGACCA
AGCCAGCCACACCGAGCGGTCTGATCCTGAACAACAACAAGCTAACGAAGATTCACCCAAAAGCCTTTCTAACCACAAAGAAGTTGCGAA
GGCTGTATCTGTCCCACAATCAACTAAGTGAAATACCACTTAATCTTCCCAAATCATTAGCAGAACTCAGAATTCATGAAAATAAAGTTA
AGAAAATACAAAAGGACACATTCAAAGGAATGAATGCTTTACACGTTTTGGAAATGAGTGCAAACCCTCTTGATAATAATGGGATAGAGC

>9705_9705_3_BICD2-ASPN_BICD2_chr9_95477535_ENST00000375512_ASPN_chr9_95228853_ENST00000395538_length(amino acids)=951AA_BP=1
MREPQWEPAQPSATMSAPSEEEEYARLVMEAQPEWLRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEME
QLKEAFGQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLASVAQELKEINQNVEIQRGRLRDD
IKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNS
LRKELSHYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKKEGLAPPSPSLVSDLLSELNISEIQ
KLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLSEQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILA
CKYHVAVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLARLEKELKKVSDVAGETQGSLSVAQDE
LVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGGAGRTSPGGRTSPEARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP
LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQELGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEV
ALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRL
ELLELDHEQTRRGRAKAAPKTKPATPSGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BICD2-ASPN

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	BICD2	chr9:95477535	chr9:95228853	ENST00000375512	-	7	8	334_599	823.0	825.0	KIF5A
Hgene	BICD2	chr9:95477535	chr9:95228853	ENST00000375512	-	7	8	590_824	823.0	825.0	RANBP2
Tgene	ASPN	chr9:95477535	chr9:95228853	ENST00000375544		2	8	166_212	129.0	381.0	TGFB1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	BICD2	chr9:95477535	chr9:95228853	ENST00000356884	-	1	7	334_599	0	856.0	KIF5A
Hgene	BICD2	chr9:95477535	chr9:95228853	ENST00000356884	-	1	7	590_824	0	856.0	RANBP2

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for BICD2-ASPN

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BICD2-ASPN

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source