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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:URI1-ARHGAP33 (FusionGDB2 ID:97064)

Fusion Gene Summary for URI1-ARHGAP33

Fusion gene summary

Fusion gene information	Fusion gene name: URI1-ARHGAP33
	Fusion gene ID: 97064
		Hgene	Tgene
	Gene symbol	URI1	ARHGAP33
	Gene ID	8725	115703
	Gene name	URI1 prefoldin like chaperone	Rho GTPase activating protein 33
	Synonyms	C19orf2\|NNX3\|PPP1R19\|RMP\|URI	NOMA-GAP\|SNX26\|TCGAP
	Cytomap	19q12	19q13.12
	Type of gene	protein-coding	protein-coding
	Description	unconventional prefoldin RPB5 interactor 1RNA polymerase II subunit 5-mediating proteinRPB5-mediating proteinprotein phosphatase 1, regulatory subunit 19	rho GTPase-activating protein 33neurite outgrowth multiadaptor RhoGAP proteinrho-type GTPase-activating protein 33sorting nexin 26tc10/CDC42 GTPase-activating protein
	Modification date	20200313	20200313
	UniProtAcc	O94763	O14559
	Ensembl transtripts involved in fusion gene	ENST00000312051, ENST00000542441, ENST00000392271, ENST00000360605, ENST00000574176,	ENST00000221905, ENST00000007510, ENST00000314737, ENST00000378944,
Fusion gene scores	* DoF score	30 X 13 X 12=4680	1 X 1 X 1=1
	# samples	40	1
	** MAII score	log2(40/4680*10)=-3.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: URI1 [Title/Abstract] AND ARHGAP33 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	URI1(30433571)-ARHGAP33(36275074), # samples:3
Anticipated loss of major functional domain due to fusion event.	URI1-ARHGAP33 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	URI1	GO:0000122	negative regulation of transcription by RNA polymerase II	12737519\|15367675\|21730289
Hgene	URI1	GO:0001558	regulation of cell growth	21730289
Hgene	URI1	GO:0071363	cellular response to growth factor stimulus	17936702
Hgene	URI1	GO:0071383	cellular response to steroid hormone stimulus	21730289

Fusion gene breakpoints across URI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARHGAP33 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-BK-A0CC-01A	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+

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Fusion Gene ORF analysis for URI1-ARHGAP33

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000312051	ENST00000221905	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
5CDS-intron	ENST00000542441	ENST00000221905	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
5UTR-3CDS	ENST00000392271	ENST00000007510	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
5UTR-3CDS	ENST00000392271	ENST00000314737	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
5UTR-3CDS	ENST00000392271	ENST00000378944	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
5UTR-intron	ENST00000392271	ENST00000221905	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
Frame-shift	ENST00000542441	ENST00000007510	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
Frame-shift	ENST00000542441	ENST00000314737	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
Frame-shift	ENST00000542441	ENST00000378944	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
In-frame	ENST00000312051	ENST00000007510	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
In-frame	ENST00000312051	ENST00000314737	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
In-frame	ENST00000312051	ENST00000378944	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
intron-3CDS	ENST00000360605	ENST00000007510	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
intron-3CDS	ENST00000360605	ENST00000314737	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
intron-3CDS	ENST00000360605	ENST00000378944	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
intron-3CDS	ENST00000574176	ENST00000007510	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
intron-3CDS	ENST00000574176	ENST00000314737	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
intron-3CDS	ENST00000574176	ENST00000378944	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
intron-intron	ENST00000360605	ENST00000221905	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+
intron-intron	ENST00000574176	ENST00000221905	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000312051

URI1

chr19

30433571

ENST00000378944

ARHGAP33

chr19

36275074

2899

147

2505

831

ENST00000312051

URI1

chr19

30433571

ENST00000007510

ARHGAP33

chr19

36275074

2983

147

2589

859

ENST00000312051

URI1

chr19

30433571

ENST00000314737

ARHGAP33

chr19

36275074

2500

147

2106

698

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000312051	ENST00000378944	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+	0.1538118	0.8461882
ENST00000312051	ENST00000007510	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+	0.10302077	0.8969792
ENST00000312051	ENST00000314737	URI1	chr19	30433571	+	ARHGAP33	chr19	36275074	+	0.30401662	0.69598335

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Fusion Genomic Features for URI1-ARHGAP33

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
URI1	chr19	30433571	+	ARHGAP33	chr19	36275073	+	5.24E-13	1
URI1	chr19	30433571	+	ARHGAP33	chr19	36275073	+	5.24E-13	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for URI1-ARHGAP33

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:30433571/chr19:36275074)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
URI1 O94763	ARHGAP33 O14559
FUNCTION: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.	FUNCTION: May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000007510

1006_1009

473

1288.0

Compositional bias

Note=Poly-Gly

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000007510

1183_1188

473

1288.0

Compositional bias

Note=Poly-Ser

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000007510

1266_1273

473

1288.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000007510

677_699

473

1288.0

Compositional bias

Note=Poly-Ser

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000007510

874_879

473

1288.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000007510

889_893

473

1288.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000314737

1006_1009

473

1127.0

Compositional bias

Note=Poly-Gly

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000314737

1183_1188

473

1127.0

Compositional bias

Note=Poly-Ser

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000314737

1266_1273

473

1127.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000314737

677_699

473

1127.0

Compositional bias

Note=Poly-Ser

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000314737

874_879

473

1127.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000314737

889_893

473

1127.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000378944

1006_1009

337

1124.0

Compositional bias

Note=Poly-Gly

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000378944

1183_1188

337

1124.0

Compositional bias

Note=Poly-Ser

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000378944

1266_1273

337

1124.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000378944

677_699

337

1124.0

Compositional bias

Note=Poly-Ser

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000378944

874_879

337

1124.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000378944

889_893

337

1124.0

Compositional bias

Note=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

URI1

chr19:30433571

chr19:36275074

ENST00000360605

299_311

476.0

Compositional bias

Note=Poly-Asp

Hgene

URI1

chr19:30433571

chr19:36275074

ENST00000360605

314_321

476.0

Compositional bias

Note=Poly-Asp

Hgene

URI1

chr19:30433571

chr19:36275074

ENST00000392271

299_311

460.0

Compositional bias

Note=Poly-Asp

Hgene

URI1

chr19:30433571

chr19:36275074

ENST00000392271

314_321

460.0

Compositional bias

Note=Poly-Asp

Hgene

URI1

chr19:30433571

chr19:36275074

ENST00000542441

299_311

536.0

Compositional bias

Note=Poly-Asp

Hgene

URI1

chr19:30433571

chr19:36275074

ENST00000542441

314_321

536.0

Compositional bias

Note=Poly-Asp

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000007510

126_129

473

1288.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000314737

126_129

473

1127.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000378944

126_129

337

1124.0

Compositional bias

Note=Poly-Pro

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000007510

186_248

473

1288.0

Domain

SH3

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000007510

315_510

473

1288.0

Domain

Rho-GAP

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000007510

59_168

473

1288.0

Domain

Note=PX%3B atypical

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000314737

186_248

473

1127.0

Domain

SH3

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000314737

315_510

473

1127.0

Domain

Rho-GAP

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000314737

59_168

473

1127.0

Domain

Note=PX%3B atypical

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000378944

186_248

337

1124.0

Domain

SH3

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000378944

315_510

337

1124.0

Domain

Rho-GAP

Tgene

ARHGAP33

chr19:30433571

chr19:36275074

ENST00000378944

59_168

337

1124.0

Domain

Note=PX%3B atypical

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Fusion Gene Sequence for URI1-ARHGAP33

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>97064_97064_1_URI1-ARHGAP33_URI1_chr19_30433571_ENST00000312051_ARHGAP33_chr19_36275074_ENST00000007510_length(transcript)=2983nt_BP=147nt
ACACGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCT
GCCCTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTCCATGGAGCTGGAGTCAGTGGGAATGGGTGG
CGCGGCGGCGTTCCGGGAAGTTCGGGTGCAGTCGGTGGTGGTGGAGTTTCTGCTCACCCATGTGGACGTCCTGTTCAGCGACACCTTCAC
CTCCGCCGGCCTCGACCCTGCAGGCCGCTGCCTGCTCCCCAGGCCCAAGTCCCTTGCGGGCAGCTGCCCCTCCACCCGCCTGCTGACGCT
GGAGGAAGCCCAGGCACGCACCCAGGGCCGGCTGGGGACGCCCACGGAGCCCACAACTCCCAAGGCCCCGGCCTCACCTGCGGAAAGGAG
GAAAGGGGAGAGAGGGGAGAAGCAGCGGAAGCCAGGGGGCAGCAGCTGGAAGACGTTCTTTGCACTGGGCCGGGGCCCCAGTGTCCCTCG
AAAGAAGCCCCTGCCCTGGCTGGGGGGCACCCGTGCCCCACCGCAGCCTTCAGGCAGCAGACCCGACACCGTCACACTGAGATCTGCCAA
GAGCGAGGAGTCTCTGTCATCGCAGGCCAGCGGGGCTGGCCTCCAGAGGCTGCACAGGCTGCGGCGACCCCACTCCAGCAGCGACGCTTT
CCCTGTGGGCCCAGCACCTGCTGGCTCCTGCGAGAGCCTGTCCTCGTCCTCCTCCTCCGAGTCCTCCTCCTCTGAGTCCTCCTCTTCCTC
CTCTGAGTCCTCAGCAGCTGGGCTGGGGGCACTCTCTGGGTCTCCCTCACACCGTACCTCAGCCTGGCTAGATGATGGTGATGAGCTGGA
CTTCAGCCCACCCCGCTGCCTGGAGGGACTCCGGGGGCTGGACTTTGATCCCTTAACCTTCCGCTGCAGCAGCCCCACCCCAGGGGATCC
CGCACCTCCCGCCAGCCCAGCACCCCCCGCCCCTGCCTCTGCCTTCCCACCCAGGGTGACCCCCCAGGCCATCTCGCCCCGGGGGCCCAC
CAGCCCCGCCTCGCCTGCTGCCCTAGACATCTCAGAGCCCCTGGCTGTATCAGTGCCACCCGCTGTCCTAGAACTGCTGGGGGCTGGGGG
AGCACCTGCCTCAGCCACCCCAACACCAGCTCTCAGCCCCGGCCGGAGCCTGCGCCCCCATCTCATACCCCTGCTGCTGCGAGGAGCCGA
GGCCCCGCTGACTGACGCCTGCCAGCAGGAGATGTGCAGCAAGCTCCGGGGAGCCCAGGGCCCACTCGGTCCTGATATGGAGTCACCACT
GCCACCCCCTCCCCTGTCTCTCCTGCGCCCTGGGGGTGCCCCACCCCCGCCCCCTAAGAACCCAGCACGCCTCATGGCCCTGGCCCTGGC
TGAGCGGGCTCAGCAGGTGGCCGAGCAACAGAGCCAGCAGGAGTGTGGGGGCACCCCACCTGCTTCCCAATCCCCCTTCCACCGCTCGCT
GTCTCTGGAGGTGGGCGGGGAGCCCCTGGGGACCTCAGGGAGTGGGCCACCTCCCAACTCCCTAGCACACCCGGGTGCCTGGGTCCCGGG
ACCCCCACCCTACTTACCAAGGCAACAAAGTGATGGGAGCCTGCTGAGGAGCCAGCGGCCCATGGGGACCTCAAGGAGGGGACTCCGAGG
CCCTGCCCAGGTCAGTGCCCAGCTCAGGGCAGGTGGCGGGGGCAGGGATGCGCCAGAGGCAGCAGCCCAGTCCCCATGTTCTGTCCCCTC
ACAGGTTCCTACCCCCGGCTTCTTCTCCCCAGCCCCCAGGGAGTGCCTGCCACCCTTCCTCGGGGTCCCCAAGCCAGGCTTGTACCCCCT
GGGCCCCCCATCCTTCCAGCCCAGTTCCCCAGCCCCAGTCTGGAGGAGCTCTCTGGGCCCCCCTGCACCACTCGACAGGGGAGAGAACCT
GTACTATGAGATCGGGGCAAGTGAGGGGTCCCCCTATTCTGGCCCCACCCGCTCCTGGAGTCCCTTTCGCTCCATGCCCCCCGACAGGCT
CAATGCCTCCTACGGCATGCTTGGCCAATCACCCCCACTCCACAGGTCCCCCGACTTCCTGCTCAGCTACCCGCCAGCCCCCTCCTGCTT
TCCCCCTGACCACCTTGGCTACTCAGCCCCCCAGCACCCTGCTCGGCGCCCTACACCGCCTGAGCCCCTCTACGTCAACCTAGCTCTAGG
GCCCAGGGGTCCCTCACCTGCCTCTTCCTCCTCCTCTTCCCCTCCTGCCCACCCCCGAAGCCGTTCAGATCCCGGTCCCCCAGTCCCCCG
CCTTCCCCAGAAACAACGGGCACCCTGGGGACCCCGTACCCCTCATAGGGTGCCGGGTCCCTGGGGCCCTCCTGAGCCTCTCCTGCTCTA
CAGGGCAGCCCCGCCAGCCTACGGAAGGGGGGGCGAGCTCCACCGAGGGTCCTTGTACAGAAATGGAGGGCAAAGAGGGGAGGGGGCTGG
TCCCCCACCCCCTTACCCCACTCCCAGCTGGTCCCTCCACTCTGAGGGCCAGACCCGAAGCTACTGCTGAGCACCAGCTGGGAGGGGCCG
TCCTTCCTTCCCTTCACCCTCACTGGATCTTGGCCCAACCAAATCCCTTGTTTTGTATTTTCTTGAACCCCGACCACTACCCCAGGTTTC
TAACTTTGTAACTTGCTTCTGATGTGGGTCCCTAACCTATAATCTCAGCTTCCCTACCCTGGACTGAAGGGTCTGCCCATCCCCCCACCA
CCCTCCATCCTGGGGGCCCTCGCACAAATCTGGGGTGGGAGGGGCTAGGCTGACCCCATCCTCCTCTCCCTCCAGGAGCCCCCAGCATGT
CCTGACCTGTGCACGGGGATGGGGGGACAACTCCTACCCTTCTTTCCCCACATGCCCCACTAAACCATCTGACAACATTAATGAATAAAA

>97064_97064_1_URI1-ARHGAP33_URI1_chr19_30433571_ENST00000312051_ARHGAP33_chr19_36275074_ENST00000007510_length(amino acids)=859AA_BP=45
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAG
LDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKP
LPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSES
SAAGLGALSGSPSHRTSAWLDDGDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPASPAPPAPASAFPPRVTPQAISPRGPTSPA
SPAALDISEPLAVSVPPAVLELLGAGGAPASATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPP
PLSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGTSGSGPPPNSLAHPGAWVPGPPP
YLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPP
SFQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPPAPSCFPPD
HLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAA

--------------------------------------------------------------
>97064_97064_2_URI1-ARHGAP33_URI1_chr19_30433571_ENST00000312051_ARHGAP33_chr19_36275074_ENST00000314737_length(transcript)=2500nt_BP=147nt
ACACGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCT
GCCCTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTCCATGGAGCTGGAGTCAGTGGGAATGGGTGG
CGCGGCGGCGTTCCGGGAAGTTCGGGTGCAGTCGGTGGTGGTGGAGTTTCTGCTCACCCATGTGGACGTCCTGTTCAGCGACACCTTCAC
CTCCGCCGGCCTCGACCCTGCAGGCCGCTGCCTGCTCCCCAGGCCCAAGTCCCTTGCGGGCAGCTGCCCCTCCACCCGCCTGCTGACGCT
GGAGGAAGCCCAGGCACGCACCCAGGGCCGGCTGGGGACGCCCACGGAGCCCACAACTCCCAAGGCCCCGGCCTCACCTGCGGAAAGGAG
GAAAGGGGAGAGAGGGGAGAAGCAGCGGAAGCCAGGGGGCAGCAGCTGGAAGACGTTCTTTGCACTGGGCCGGGGCCCCAGTGTCCCTCG
AAAGAAGCCCCTGCCCTGGCTGGGGGGCACCCGTGCCCCACCGCAGCCTTCAGGCAGCAGACCCGACACCGTCACACTGAGATCTGCCAA
GAGCGAGGAGTCTCTGTCATCGCAGGCCAGCGGGGCTGAACTGCTGGGGGCTGGGGGAGCACCTGCCTCAGCCACCCCAACACCAGCTCT
CAGCCCCGGCCGGAGCCTGCGCCCCCATCTCATACCCCTGCTGCTGCGAGGAGCCGAGGCCCCGCTGACTGACGCCTGCCAGCAGGAGAT
GTGCAGCAAGCTCCGGGGAGCCCAGGGCCCACTCGGTCCTGATATGGAGTCACCACTGCCACCCCCTCCCCTGTCTCTCCTGCGCCCTGG
GGGTGCCCCACCCCCGCCCCCTAAGAACCCAGCACGCCTCATGGCCCTGGCCCTGGCTGAGCGGGCTCAGCAGGTGGCCGAGCAACAGAG
CCAGCAGGAGTGTGGGGGCACCCCACCTGCTTCCCAATCCCCCTTCCACCGCTCGCTGTCTCTGGAGGTGGGCGGGGAGCCCCTGGGGAC
CTCAGGGAGTGGGCCACCTCCCAACTCCCTAGCACACCCGGGTGCCTGGGTCCCGGGACCCCCACCCTACTTACCAAGGCAACAAAGTGA
TGGGAGCCTGCTGAGGAGCCAGCGGCCCATGGGGACCTCAAGGAGGGGACTCCGAGGCCCTGCCCAGGTCAGTGCCCAGCTCAGGGCAGG
TGGCGGGGGCAGGGATGCGCCAGAGGCAGCAGCCCAGTCCCCATGTTCTGTCCCCTCACAGGTTCCTACCCCCGGCTTCTTCTCCCCAGC
CCCCAGGGAGTGCCTGCCACCCTTCCTCGGGGTCCCCAAGCCAGGCTTGTACCCCCTGGGCCCCCCATCCTTCCAGCCCAGTTCCCCAGC
CCCAGTCTGGAGGAGCTCTCTGGGCCCCCCTGCACCACTCGACAGGGGAGAGAACCTGTACTATGAGATCGGGGCAAGTGAGGGGTCCCC
CTATTCTGGCCCCACCCGCTCCTGGAGTCCCTTTCGCTCCATGCCCCCCGACAGGCTCAATGCCTCCTACGGCATGCTTGGCCAATCACC
CCCACTCCACAGGTCCCCCGACTTCCTGCTCAGCTACCCGCCAGCCCCCTCCTGCTTTCCCCCTGACCACCTTGGCTACTCAGCCCCCCA
GCACCCTGCTCGGCGCCCTACACCGCCTGAGCCCCTCTACGTCAACCTAGCTCTAGGGCCCAGGGGTCCCTCACCTGCCTCTTCCTCCTC
CTCTTCCCCTCCTGCCCACCCCCGAAGCCGTTCAGATCCCGGTCCCCCAGTCCCCCGCCTTCCCCAGAAACAACGGGCACCCTGGGGACC
CCGTACCCCTCATAGGGTGCCGGGTCCCTGGGGCCCTCCTGAGCCTCTCCTGCTCTACAGGGCAGCCCCGCCAGCCTACGGAAGGGGGGG
CGAGCTCCACCGAGGGTCCTTGTACAGAAATGGAGGGCAAAGAGGGGAGGGGGCTGGTCCCCCACCCCCTTACCCCACTCCCAGCTGGTC
CCTCCACTCTGAGGGCCAGACCCGAAGCTACTGCTGAGCACCAGCTGGGAGGGGCCGTCCTTCCTTCCCTTCACCCTCACTGGATCTTGG
CCCAACCAAATCCCTTGTTTTGTATTTTCTTGAACCCCGACCACTACCCCAGGTTTCTAACTTTGTAACTTGCTTCTGATGTGGGTCCCT
AACCTATAATCTCAGCTTCCCTACCCTGGACTGAAGGGTCTGCCCATCCCCCCACCACCCTCCATCCTGGGGGCCCTCGCACAAATCTGG
GGTGGGAGGGGCTAGGCTGACCCCATCCTCCTCTCCCTCCAGGAGCCCCCAGCATGTCCTGACCTGTGCACGGGGATGGGGGGACAACTC

>97064_97064_2_URI1-ARHGAP33_URI1_chr19_30433571_ENST00000312051_ARHGAP33_chr19_36275074_ENST00000314737_length(amino acids)=698AA_BP=45
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAG
LDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKP
LPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAELLGAGGAPASATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSK
LRGAQGPLGPDMESPLPPPPLSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGTSGS
GPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRE
CLPPFLGVPKPGLYPLGPPSFQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLH
RSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTP

--------------------------------------------------------------
>97064_97064_3_URI1-ARHGAP33_URI1_chr19_30433571_ENST00000312051_ARHGAP33_chr19_36275074_ENST00000378944_length(transcript)=2899nt_BP=147nt
ACACGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCT
GCCCTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTCCATGGAGCTGGAGTCAGTGGGAATGGGTGG
CGCGGCGGCGTTCCGGGAAGTTCGGGTGCAGTCGGTGGTGGTGGAGTTTCTGCTCACCCATGTGGACGTCCTGTTCAGCGACACCTTCAC
CTCCGCCGGCCTCGACCCTGCAGGCCGCTGCCTGCTCCCCAGGCCCAAGTCCCTTGCGGGCAGCTGCCCCTCCACCCGCCTGCTGACGCT
GGAGGAAGCCCAGGCACGCACCCAGGGCCGGCTGGGGACGCCCACGGAGCCCACAACTCCCAAGGCCCCGGCCTCACCTGCGGAAAGGAG
GAAAGGGGAGAGAGGGGAGAAGCAGCGGAAGCCAGGGGGCAGCAGCTGGAAGACGTTCTTTGCACTGGGCCGGGGCCCCAGTGTCCCTCG
AAAGAAGCCCCTGCCCTGGCTGGGGGGCACCCGTGCCCCACCGCAGCCTTCAGGCAGCAGACCCGACACCGTCACACTGAGATCTGCCAA
GAGCGAGGAGTCTCTGTCATCGCAGGCCAGCGGGGCTGGCCTCCAGAGGCTGCACAGGCTGCGGCGACCCCACTCCAGCAGCGACGCTTT
CCCTGTGGGCCCAGCACCTGCTGGCTCCTGCGAGAGCCTGTCCTCGTCCTCCTCCTCCGAGTCCTCCTCCTCTGAGTCCTCCTCTTCCTC
CTCTGAGTCCTCAGCAGCTGGGCTGGGGGCACTCTCTGGGTCTCCCTCACACCGTACCTCAGCCTGGCTAGATGATGGTGATGAGCTGGA
CTTCAGCCCACCCCGCTGCCTGGAGGGACTCCGGGGGCTGGACTTTGATCCCTTAACCTTCCGCTGCAGCAGCCCCACCCCAGGGGATCC
CGCACCTCCCGCCAGCCCAGCACCCCCCGCCCCTGCCTCTGCCTTCCCACCCAGGGTGACCCCCCAGGCCATCTCGCCCCGGGGGCCCAC
CAGCCCCGCCTCGCCTGCTGCCCTAGACATCTCAGAGCCCCTGGCTGTATCAGTGCCACCCGCTGTCCTAGAACTGCTGGGGGCTGGGGG
AGCACCTGCCTCAGCCACCCCAACACCAGCTCTCAGCCCCGGCCGGAGCCTGCGCCCCCATCTCATACCCCTGCTGCTGCGAGGAGCCGA
GGCCCCGCTGACTGACGCCTGCCAGCAGGAGATGTGCAGCAAGCTCCGGGGAGCCCAGGGCCCACTCGGTCCTGATATGGAGTCACCACT
GCCACCCCCTCCCCTGTCTCTCCTGCGCCCTGGGGGTGCCCCACCCCCGCCCCCTAAGAACCCAGCACGCCTCATGGCCCTGGCCCTGGC
TGAGCGGGCTCAGCAGGTGGCCGAGCAACAGAGCCAGCAGGAGTGTGGGGGCACCCCACCTGCTTCCCAATCCCCCTTCCACCGCTCGCT
GTCTCTGGAGGTGGGCGGGGAGCCCCTGGGGACCTCAGGGAGTGGGCCACCTCCCAACTCCCTAGCACACCCGGGTGCCTGGGTCCCGGG
ACCCCCACCCTACTTACCAAGGCAACAAAGTGATGGGAGCCTGCTGAGGAGCCAGCGGCCCATGGGGACCTCAAGGAGGGGACTCCGAGG
CCCTGCCCAGGTTCCTACCCCCGGCTTCTTCTCCCCAGCCCCCAGGGAGTGCCTGCCACCCTTCCTCGGGGTCCCCAAGCCAGGCTTGTA
CCCCCTGGGCCCCCCATCCTTCCAGCCCAGTTCCCCAGCCCCAGTCTGGAGGAGCTCTCTGGGCCCCCCTGCACCACTCGACAGGGGAGA
GAACCTGTACTATGAGATCGGGGCAAGTGAGGGGTCCCCCTATTCTGGCCCCACCCGCTCCTGGAGTCCCTTTCGCTCCATGCCCCCCGA
CAGGCTCAATGCCTCCTACGGCATGCTTGGCCAATCACCCCCACTCCACAGGTCCCCCGACTTCCTGCTCAGCTACCCGCCAGCCCCCTC
CTGCTTTCCCCCTGACCACCTTGGCTACTCAGCCCCCCAGCACCCTGCTCGGCGCCCTACACCGCCTGAGCCCCTCTACGTCAACCTAGC
TCTAGGGCCCAGGGGTCCCTCACCTGCCTCTTCCTCCTCCTCTTCCCCTCCTGCCCACCCCCGAAGCCGTTCAGATCCCGGTCCCCCAGT
CCCCCGCCTTCCCCAGAAACAACGGGCACCCTGGGGACCCCGTACCCCTCATAGGGTGCCGGGTCCCTGGGGCCCTCCTGAGCCTCTCCT
GCTCTACAGGGCAGCCCCGCCAGCCTACGGAAGGGGGGGCGAGCTCCACCGAGGGTCCTTGTACAGAAATGGAGGGCAAAGAGGGGAGGG
GGCTGGTCCCCCACCCCCTTACCCCACTCCCAGCTGGTCCCTCCACTCTGAGGGCCAGACCCGAAGCTACTGCTGAGCACCAGCTGGGAG
GGGCCGTCCTTCCTTCCCTTCACCCTCACTGGATCTTGGCCCAACCAAATCCCTTGTTTTGTATTTTCTTGAACCCCGACCACTACCCCA
GGTTTCTAACTTTGTAACTTGCTTCTGATGTGGGTCCCTAACCTATAATCTCAGCTTCCCTACCCTGGACTGAAGGGTCTGCCCATCCCC
CCACCACCCTCCATCCTGGGGGCCCTCGCACAAATCTGGGGTGGGAGGGGCTAGGCTGACCCCATCCTCCTCTCCCTCCAGGAGCCCCCA
GCATGTCCTGACCTGTGCACGGGGATGGGGGGACAACTCCTACCCTTCTTTCCCCACATGCCCCACTAAACCATCTGACAACATTAATGA

>97064_97064_3_URI1-ARHGAP33_URI1_chr19_30433571_ENST00000312051_ARHGAP33_chr19_36275074_ENST00000378944_length(amino acids)=831AA_BP=45
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAG
LDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKP
LPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSES
SAAGLGALSGSPSHRTSAWLDDGDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPASPAPPAPASAFPPRVTPQAISPRGPTSPA
SPAALDISEPLAVSVPPAVLELLGAGGAPASATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPP
PLSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGTSGSGPPPNSLAHPGAWVPGPPP
YLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPAPVWRSSLGPPAPLDRGENLY
YEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGP
RGPSPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGGELHRGSLYRNGGQRGEGAGP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for URI1-ARHGAP33

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for URI1-ARHGAP33

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for URI1-ARHGAP33

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source