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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:URI1-EIF3H (FusionGDB2 ID:97070)

Fusion Gene Summary for URI1-EIF3H

check button Fusion gene summary
Fusion gene informationFusion gene name: URI1-EIF3H
Fusion gene ID: 97070
HgeneTgene
Gene symbol

URI1

EIF3H

Gene ID

8725

8667

Gene nameURI1 prefoldin like chaperoneeukaryotic translation initiation factor 3 subunit H
SynonymsC19orf2|NNX3|PPP1R19|RMP|URIEIF3S3|eIF3-gamma|eIF3-p40
Cytomap

19q12

8q23.3-q24.11

Type of geneprotein-codingprotein-coding
Descriptionunconventional prefoldin RPB5 interactor 1RNA polymerase II subunit 5-mediating proteinRPB5-mediating proteinprotein phosphatase 1, regulatory subunit 19eukaryotic translation initiation factor 3 subunit HeIF-3-gammaeIF3 p40 subuniteukaryotic translation initiation factor 3 subunit 3eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD)eukaryotic translation initiation factor 3, subunit 3
Modification date2020031320200313
UniProtAcc

O94763

O15372

Ensembl transtripts involved in fusion geneENST00000392271, ENST00000312051, 
ENST00000542441, ENST00000360605, 
ENST00000574176, 		ENST00000276682, 
ENST00000521861, 
Fusion gene scores* DoF score30 X 13 X 12=468020 X 15 X 12=3600
# samples 4032
** MAII scorelog2(40/4680*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/3600*10)=-3.49185309632968
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: URI1 [Title/Abstract] AND EIF3H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF3H(117738254)-URI1(30476129), # samples:1
EIF3H(117738255)-URI1(30476130), # samples:1
URI1(30433571)-EIF3H(117671219), # samples:3
Anticipated loss of major functional domain due to fusion event.EIF3H-URI1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EIF3H-URI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EIF3H-URI1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
URI1-EIF3H seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
URI1-EIF3H seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
URI1-EIF3H seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneURI1

GO:0000122

negative regulation of transcription by RNA polymerase II

12737519|15367675|21730289

HgeneURI1

GO:0001558

regulation of cell growth

21730289

HgeneURI1

GO:0071363

cellular response to growth factor stimulus

17936702

HgeneURI1

GO:0071383

cellular response to steroid hormone stimulus

21730289

TgeneEIF3H

GO:0006413

translational initiation

17581632


check buttonFusion gene breakpoints across URI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF3H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A94O-01AURI1chr19

30433571

+EIF3Hchr8

117661165

-
ChimerDB4STADTCGA-VQ-A94O-01AURI1chr19

30433571

+EIF3Hchr8

117668244

-
ChimerDB4STADTCGA-VQ-A94O-01AURI1chr19

30433571

+EIF3Hchr8

117671219

-
ChimerDB4STADTCGA-VQ-A94OURI1chr19

30433571

+EIF3Hchr8

117668244

-
ChimerDB4STADTCGA-VQ-A94OURI1chr19

30433571

+EIF3Hchr8

117671219

-


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Fusion Gene ORF analysis for URI1-EIF3H

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000392271ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117661165

-
5UTR-3CDSENST00000392271ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117671219

-
5UTR-3CDSENST00000392271ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117668244

-
5UTR-3CDSENST00000392271ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117661165

-
5UTR-3CDSENST00000392271ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117671219

-
5UTR-3CDSENST00000392271ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117668244

-
Frame-shiftENST00000312051ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117671219

-
Frame-shiftENST00000312051ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117671219

-
Frame-shiftENST00000542441ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117661165

-
Frame-shiftENST00000542441ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117671219

-
Frame-shiftENST00000542441ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117668244

-
Frame-shiftENST00000542441ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117661165

-
Frame-shiftENST00000542441ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117671219

-
Frame-shiftENST00000542441ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117668244

-
In-frameENST00000312051ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117661165

-
In-frameENST00000312051ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117668244

-
In-frameENST00000312051ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117661165

-
In-frameENST00000312051ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117668244

-
intron-3CDSENST00000360605ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117661165

-
intron-3CDSENST00000360605ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117671219

-
intron-3CDSENST00000360605ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117668244

-
intron-3CDSENST00000360605ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117661165

-
intron-3CDSENST00000360605ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117671219

-
intron-3CDSENST00000360605ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117668244

-
intron-3CDSENST00000574176ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117661165

-
intron-3CDSENST00000574176ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117671219

-
intron-3CDSENST00000574176ENST00000276682URI1chr19

30433571

+EIF3Hchr8

117668244

-
intron-3CDSENST00000574176ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117661165

-
intron-3CDSENST00000574176ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117671219

-
intron-3CDSENST00000574176ENST00000521861URI1chr19

30433571

+EIF3Hchr8

117668244

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000312051URI1chr1930433571+ENST00000521861EIF3Hchr8117668244-352514710648212
ENST00000312051URI1chr1930433571+ENST00000276682EIF3Hchr8117668244-82214710648212
ENST00000312051URI1chr1930433571+ENST00000521861EIF3Hchr8117661165-337514710498162
ENST00000312051URI1chr1930433571+ENST00000276682EIF3Hchr8117661165-67214710498162

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000312051ENST00000521861URI1chr1930433571+EIF3Hchr8117668244-0.0021197520.9978802
ENST00000312051ENST00000276682URI1chr1930433571+EIF3Hchr8117668244-0.0024606510.9975394
ENST00000312051ENST00000521861URI1chr1930433571+EIF3Hchr8117661165-0.0111810260.98881894
ENST00000312051ENST00000276682URI1chr1930433571+EIF3Hchr8117661165-0.0075069530.9924931

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Fusion Genomic Features for URI1-EIF3H


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for URI1-EIF3H


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:117738254/chr8:30476129)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
URI1

O94763

EIF3H

O15372

FUNCTION: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneURI1chr19:30433571chr8:117661165ENST00000360605+111299_3110476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117661165ENST00000360605+111314_3210476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117661165ENST00000392271+111299_3110460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117661165ENST00000392271+111314_3210460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117661165ENST00000542441+111299_31139536.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117661165ENST00000542441+111314_32139536.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117668244ENST00000360605+111299_3110476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117668244ENST00000360605+111314_3210476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117668244ENST00000392271+111299_3110460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117668244ENST00000392271+111314_3210460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117668244ENST00000542441+111299_31139536.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30433571chr8:117668244ENST00000542441+111314_32139536.0Compositional biasNote=Poly-Asp
TgeneEIF3Hchr19:30433571chr8:117661165ENST000005218614839_173235353.0DomainMPN
TgeneEIF3Hchr19:30433571chr8:117668244ENST000005218613839_173185353.0DomainMPN


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Fusion Gene Sequence for URI1-EIF3H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97070_97070_1_URI1-EIF3H_URI1_chr19_30433571_ENST00000312051_EIF3H_chr8_117661165_ENST00000276682_length(transcript)=672nt_BP=147nt
ACACGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCT
GCCCTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGCAATCATTTGGGGAAGAATCTACAGTTGCTGAT
GGACAGAGTGGATGAAATGAGCCAAGATATAGTTAAATACAACACATACATGAGGAATACTAGTAAACAACAGCAGCAGAAACATCAGTA
TCAGCAGCGTCGCCAGCAGGAGAATATGCAGCGCCAGAGCCGAGGAGAACCCCCGCTCCCTGAGGAGGACCTGTCCAAACTCTTCAAACC
ACCACAGCCGCCTGCCAGGATGGACTCGCTGCTCATTGCAGGCCAGATAAACACTTACTGCCAGAACATCAAGGAGTTCACTGCCCAAAA
CTTAGGCAAGCTCTTCATGGCCCAGGCTCTTCAAGAATACAACAACTAAGAAAAGGAAGTTTCCAGAAAAGAAGTTAACATGAACTCTTG
AAGTCACACCAGGGCAACTCTTGGAAGAAATATATTTGCATATTGAAAAGCACAGAGGATTTCTTTAGTGTCATTGCCGATTTTGGCTAT

>97070_97070_1_URI1-EIF3H_URI1_chr19_30433571_ENST00000312051_EIF3H_chr8_117661165_ENST00000276682_length(amino acids)=162AA_BP=45
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQR

--------------------------------------------------------------
>97070_97070_2_URI1-EIF3H_URI1_chr19_30433571_ENST00000312051_EIF3H_chr8_117661165_ENST00000521861_length(transcript)=3375nt_BP=147nt
ACACGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCT
GCCCTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGCAATCATTTGGGGAAGAATCTACAGTTGCTGAT
GGACAGAGTGGATGAAATGAGCCAAGATATAGTTAAATACAACACATACATGAGGAATACTAGTAAACAACAGCAGCAGAAACATCAGTA
TCAGCAGCGTCGCCAGCAGGAGAATATGCAGCGCCAGAGCCGAGGAGAACCCCCGCTCCCTGAGGAGGACCTGTCCAAACTCTTCAAACC
ACCACAGCCGCCTGCCAGGATGGACTCGCTGCTCATTGCAGGCCAGATAAACACTTACTGCCAGAACATCAAGGAGTTCACTGCCCAAAA
CTTAGGCAAGCTCTTCATGGCCCAGGCTCTTCAAGAATACAACAACTAAGAAAAGGAAGTTTCCAGAAAAGAAGTTAACATGAACTCTTG
AAGTCACACCAGGGCAACTCTTGGAAGAAATATATTTGCATATTGAAAAGCACAGAGGATTTCTTTAGTGTCATTGCCGATTTTGGCTAT
AACAGTGTCTTTCTAGCCATAATAAAATAAAACAAAATCTTGACTGCTTGCTCATTTGATTTTAGATGTATTTTCTCTGGCTTACTTTTG
TTTGCTTATACTTGTTTATTTCTAAAAGCTAAAACAAGCCCTGACCGGAAGTTTCACCAGGCAGAAACCTATAGGCTCCACCACTTTTGC
TGCCTCTCAGGTGCCACCTTTCAACCCACTTCTCCCAACTACTTATCCCAGCTCCTGACCCCGAGGCCCTGGCATCTACTGTGAATATTT
TTTTTTTGAATTTTTATACTTCGCTGCTCCCAAATGAGCACCCCGAGAGAAGTCCAGGCTTCATGTACTTGCCCAGGAATTCCTTGTCCC
CGGACCCGGAATCACTTGGCCTAATTCCGGTCAGTCTGCCTTTTCATTTCTGCAGGTGATGGTCAACCAGTCCCCGTACTCATAGGCCAT
GGGACACAAGATTATTATTATCATCATTATTTTTAAAGACAGAGTCTCACTTTGTTGCCCAGGCTGGAGTGTAGTGGCACAATCTCAGCT
CGCTGCAACCTCCACCTTCTGAGTTCAAGCGATTCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGTGTGCCATCACGCCTGG
CTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTGCATCTCCTGACCTCAAGTGATTCACCTGCTTCT
GTCTCCCAAAGTGCTGGGAATACAGGCATGAGCCACCACTCCTGGACAGGCCACAGAAATTTTAAAGAAAAGAATCATGCCACCACAAGT
AAACTTCATTTTGTTTATATTATTTAGGACTTCACATTTGTCTTCCGAAACCATGAAGTATAATTCTGCTAACAGCAAGTGTTGTGAATG
AGGAATTAGGAATTAGGAGAATGGTAGTACATTGGGAAAAACATATTTTAGTAATTTTTATATTTTAAAGATAATCACAGATTTTGCTGT
TTGTGCATCACCAAAATCAGTGAGATCTGCCAGCTGGTGGGGGTGTGCCTATGAGAATTTTTGATTATGATCCCCTAGGAGGGTTATCAA
AAAAGGAGATGGGTGAAAGATCAGGAGAGTCGAGAAATTCATTTTTTGGACAACATTGTTTTGAAGGCACTACTGGGGCTCTGGGATCAG
GCAGCCAGATTGAAACCTGGCTCCTCCTTTTCCTAAGTTATTTAACCTCCCTGTGCCTCACTTTTTGTCAACCAGATAAGATAAGAAATG
AGAGCAGGTCTGTTACCTCACAAGGTGGCTGTGAGTGTTGAAGACGTTTGTTGGGGGTTTGGGTGAAGCATGCAAACTCTGGTTGGTATG
TGGCAGCCACTCAGCCTGTATTTATGATGAGGGAGGCATTCTAGGCACCCCTTCCAGGATGTTGGGTTGTTGGCTGGGTTTTACTTTAAA
AAGCTCAGGGCCTAGAACATTCTAGAATCCAAGTACTTGCTCACATATATAATTATTTCTTTAGGATAATCTTTGATATAGACTTACGAG
TCAAAGGGTATGTAAAATGTCAGCCCTTTTACCTGTATTGCCAAATTGCCTTCAAAAGTTTCTGCTGTTTTGCCCTCCTACCCATAGTGA
TAACCTTAAATTGGAGTCAACACAAATTTGAGTGTGACTGTGTTAGACAGAAGGGATATATTAACAGGTAAAACTGGCCATGGCCCCTGC
CCTTGTGGAGTATATGCTCTGTTGGTTCATTTCCTCTGCATTCTAATTTTCTAGACTTGGGATCTTATTGTGGAGTTAAACAAAGCACCC
TTAAAGTAGCAAGCGAGCAAAATAAAAGCAAGGAAAATCAGTTGGAACATAACTTATGTATTTTTTAGGATTAAGAGTAATTTAACTGAG
TCAATTCAATATGTTTTTAAAGGTGTGATTCTTAAATTCTTTATGATTGTTTAGATTTCTATATCTTGGTAACATGAATACACACTTAAT
GAAAGATTTCAGTAATTTTTGATTTGGGAATTAATCATAGTGGGAAAAACTGTTTAGGAAAACATGTCAGTGGAAATTAACTCGCCACAG
TATGTAGTGTTAGGGAATAGCTTCTGTTCGGCATTTGATTTGAGTGCTGTATTCTGACATTTTTCAGGAACAAATACATGTGATTCATCT
TCTATAAATATTTGCAGTTTCTTCAAGTTGAAATGAGAAAAGCTCGTAAATTGAGCACCAGGTCTAATAAATCATTCACTTACCCAAGAA
CAGAAAGACAGGAAAAGCTAGCATGTTAATCTAATGAAAAAATCGAATGTTAAAAAACCAAGAAAGTAGAAGATATTTGACATTAACTTT
CTAATCATTGATAATAATCTAATAATCATAACATTATTCTTAAAACCTGAAAGAATGGATTCCTGCTCCCAATGTGTTTTTAATATCAAC
TTAAACTAAAATAATTTTTTTACCTATTTTTGGAAGCTTGGAAATTGAGATGTAGTTGTCTAATGTTAACCTAATTAAGAGAGCTTGGTG
TGATTTCTCATATACAGCATCTAAATATTTAAGTTTTAATGTCTTCTAAAATATTATTACATTCTTCATACTATAGTTTTTTAACATCCT
TTAGAAAACTTGTATCAGCTTCACTTTCAAACCATGCTGGCATCGAACTCAGGTGTAGTGGTATCAGAATGTTATGAAATAATTTTTTAT

>97070_97070_2_URI1-EIF3H_URI1_chr19_30433571_ENST00000312051_EIF3H_chr8_117661165_ENST00000521861_length(amino acids)=162AA_BP=45
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQR

--------------------------------------------------------------
>97070_97070_3_URI1-EIF3H_URI1_chr19_30433571_ENST00000312051_EIF3H_chr8_117668244_ENST00000276682_length(transcript)=822nt_BP=147nt
ACACGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCT
GCCCTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGATTGAAAAAAGCAAATATCACCTTTGAGTACAT
GTTTGAAGAAGTGCCGATTGTAATTAAAAATTCACATCTGATCAATGTCCTAATGTGGGAACTTGAAAAGAAGTCAGCTGTTGCAGATAA
ACATGAATTGCTCAGCCTTGCCAGCAGCAATCATTTGGGGAAGAATCTACAGTTGCTGATGGACAGAGTGGATGAAATGAGCCAAGATAT
AGTTAAATACAACACATACATGAGGAATACTAGTAAACAACAGCAGCAGAAACATCAGTATCAGCAGCGTCGCCAGCAGGAGAATATGCA
GCGCCAGAGCCGAGGAGAACCCCCGCTCCCTGAGGAGGACCTGTCCAAACTCTTCAAACCACCACAGCCGCCTGCCAGGATGGACTCGCT
GCTCATTGCAGGCCAGATAAACACTTACTGCCAGAACATCAAGGAGTTCACTGCCCAAAACTTAGGCAAGCTCTTCATGGCCCAGGCTCT
TCAAGAATACAACAACTAAGAAAAGGAAGTTTCCAGAAAAGAAGTTAACATGAACTCTTGAAGTCACACCAGGGCAACTCTTGGAAGAAA
TATATTTGCATATTGAAAAGCACAGAGGATTTCTTTAGTGTCATTGCCGATTTTGGCTATAACAGTGTCTTTCTAGCCATAATAAAATAA

>97070_97070_3_URI1-EIF3H_URI1_chr19_30433571_ENST00000312051_EIF3H_chr8_117668244_ENST00000276682_length(amino acids)=212AA_BP=45
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRLKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHEL
LSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIA

--------------------------------------------------------------
>97070_97070_4_URI1-EIF3H_URI1_chr19_30433571_ENST00000312051_EIF3H_chr8_117668244_ENST00000521861_length(transcript)=3525nt_BP=147nt
ACACGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCT
GCCCTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGATTGAAAAAAGCAAATATCACCTTTGAGTACAT
GTTTGAAGAAGTGCCGATTGTAATTAAAAATTCACATCTGATCAATGTCCTAATGTGGGAACTTGAAAAGAAGTCAGCTGTTGCAGATAA
ACATGAATTGCTCAGCCTTGCCAGCAGCAATCATTTGGGGAAGAATCTACAGTTGCTGATGGACAGAGTGGATGAAATGAGCCAAGATAT
AGTTAAATACAACACATACATGAGGAATACTAGTAAACAACAGCAGCAGAAACATCAGTATCAGCAGCGTCGCCAGCAGGAGAATATGCA
GCGCCAGAGCCGAGGAGAACCCCCGCTCCCTGAGGAGGACCTGTCCAAACTCTTCAAACCACCACAGCCGCCTGCCAGGATGGACTCGCT
GCTCATTGCAGGCCAGATAAACACTTACTGCCAGAACATCAAGGAGTTCACTGCCCAAAACTTAGGCAAGCTCTTCATGGCCCAGGCTCT
TCAAGAATACAACAACTAAGAAAAGGAAGTTTCCAGAAAAGAAGTTAACATGAACTCTTGAAGTCACACCAGGGCAACTCTTGGAAGAAA
TATATTTGCATATTGAAAAGCACAGAGGATTTCTTTAGTGTCATTGCCGATTTTGGCTATAACAGTGTCTTTCTAGCCATAATAAAATAA
AACAAAATCTTGACTGCTTGCTCATTTGATTTTAGATGTATTTTCTCTGGCTTACTTTTGTTTGCTTATACTTGTTTATTTCTAAAAGCT
AAAACAAGCCCTGACCGGAAGTTTCACCAGGCAGAAACCTATAGGCTCCACCACTTTTGCTGCCTCTCAGGTGCCACCTTTCAACCCACT
TCTCCCAACTACTTATCCCAGCTCCTGACCCCGAGGCCCTGGCATCTACTGTGAATATTTTTTTTTTGAATTTTTATACTTCGCTGCTCC
CAAATGAGCACCCCGAGAGAAGTCCAGGCTTCATGTACTTGCCCAGGAATTCCTTGTCCCCGGACCCGGAATCACTTGGCCTAATTCCGG
TCAGTCTGCCTTTTCATTTCTGCAGGTGATGGTCAACCAGTCCCCGTACTCATAGGCCATGGGACACAAGATTATTATTATCATCATTAT
TTTTAAAGACAGAGTCTCACTTTGTTGCCCAGGCTGGAGTGTAGTGGCACAATCTCAGCTCGCTGCAACCTCCACCTTCTGAGTTCAAGC
GATTCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGTGTGCCATCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGG
TTTCACCATGTTGGCCAGGCTGGTCTGCATCTCCTGACCTCAAGTGATTCACCTGCTTCTGTCTCCCAAAGTGCTGGGAATACAGGCATG
AGCCACCACTCCTGGACAGGCCACAGAAATTTTAAAGAAAAGAATCATGCCACCACAAGTAAACTTCATTTTGTTTATATTATTTAGGAC
TTCACATTTGTCTTCCGAAACCATGAAGTATAATTCTGCTAACAGCAAGTGTTGTGAATGAGGAATTAGGAATTAGGAGAATGGTAGTAC
ATTGGGAAAAACATATTTTAGTAATTTTTATATTTTAAAGATAATCACAGATTTTGCTGTTTGTGCATCACCAAAATCAGTGAGATCTGC
CAGCTGGTGGGGGTGTGCCTATGAGAATTTTTGATTATGATCCCCTAGGAGGGTTATCAAAAAAGGAGATGGGTGAAAGATCAGGAGAGT
CGAGAAATTCATTTTTTGGACAACATTGTTTTGAAGGCACTACTGGGGCTCTGGGATCAGGCAGCCAGATTGAAACCTGGCTCCTCCTTT
TCCTAAGTTATTTAACCTCCCTGTGCCTCACTTTTTGTCAACCAGATAAGATAAGAAATGAGAGCAGGTCTGTTACCTCACAAGGTGGCT
GTGAGTGTTGAAGACGTTTGTTGGGGGTTTGGGTGAAGCATGCAAACTCTGGTTGGTATGTGGCAGCCACTCAGCCTGTATTTATGATGA
GGGAGGCATTCTAGGCACCCCTTCCAGGATGTTGGGTTGTTGGCTGGGTTTTACTTTAAAAAGCTCAGGGCCTAGAACATTCTAGAATCC
AAGTACTTGCTCACATATATAATTATTTCTTTAGGATAATCTTTGATATAGACTTACGAGTCAAAGGGTATGTAAAATGTCAGCCCTTTT
ACCTGTATTGCCAAATTGCCTTCAAAAGTTTCTGCTGTTTTGCCCTCCTACCCATAGTGATAACCTTAAATTGGAGTCAACACAAATTTG
AGTGTGACTGTGTTAGACAGAAGGGATATATTAACAGGTAAAACTGGCCATGGCCCCTGCCCTTGTGGAGTATATGCTCTGTTGGTTCAT
TTCCTCTGCATTCTAATTTTCTAGACTTGGGATCTTATTGTGGAGTTAAACAAAGCACCCTTAAAGTAGCAAGCGAGCAAAATAAAAGCA
AGGAAAATCAGTTGGAACATAACTTATGTATTTTTTAGGATTAAGAGTAATTTAACTGAGTCAATTCAATATGTTTTTAAAGGTGTGATT
CTTAAATTCTTTATGATTGTTTAGATTTCTATATCTTGGTAACATGAATACACACTTAATGAAAGATTTCAGTAATTTTTGATTTGGGAA
TTAATCATAGTGGGAAAAACTGTTTAGGAAAACATGTCAGTGGAAATTAACTCGCCACAGTATGTAGTGTTAGGGAATAGCTTCTGTTCG
GCATTTGATTTGAGTGCTGTATTCTGACATTTTTCAGGAACAAATACATGTGATTCATCTTCTATAAATATTTGCAGTTTCTTCAAGTTG
AAATGAGAAAAGCTCGTAAATTGAGCACCAGGTCTAATAAATCATTCACTTACCCAAGAACAGAAAGACAGGAAAAGCTAGCATGTTAAT
CTAATGAAAAAATCGAATGTTAAAAAACCAAGAAAGTAGAAGATATTTGACATTAACTTTCTAATCATTGATAATAATCTAATAATCATA
ACATTATTCTTAAAACCTGAAAGAATGGATTCCTGCTCCCAATGTGTTTTTAATATCAACTTAAACTAAAATAATTTTTTTACCTATTTT
TGGAAGCTTGGAAATTGAGATGTAGTTGTCTAATGTTAACCTAATTAAGAGAGCTTGGTGTGATTTCTCATATACAGCATCTAAATATTT
AAGTTTTAATGTCTTCTAAAATATTATTACATTCTTCATACTATAGTTTTTTAACATCCTTTAGAAAACTTGTATCAGCTTCACTTTCAA
ACCATGCTGGCATCGAACTCAGGTGTAGTGGTATCAGAATGTTATGAAATAATTTTTTATTTTCATTATAAACTCCATTTTTACAATAAA

>97070_97070_4_URI1-EIF3H_URI1_chr19_30433571_ENST00000312051_EIF3H_chr8_117668244_ENST00000521861_length(amino acids)=212AA_BP=45
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRLKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHEL
LSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for URI1-EIF3H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for URI1-EIF3H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for URI1-EIF3H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource