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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:URI1-VSTM2B (FusionGDB2 ID:97090)

Fusion Gene Summary for URI1-VSTM2B

check button Fusion gene summary
Fusion gene informationFusion gene name: URI1-VSTM2B
Fusion gene ID: 97090
HgeneTgene
Gene symbol

URI1

VSTM2B

Gene ID

8725

342865

Gene nameURI1 prefoldin like chaperoneV-set and transmembrane domain containing 2B
SynonymsC19orf2|NNX3|PPP1R19|RMP|URI-
Cytomap

19q12

19q12

Type of geneprotein-codingprotein-coding
Descriptionunconventional prefoldin RPB5 interactor 1RNA polymerase II subunit 5-mediating proteinRPB5-mediating proteinprotein phosphatase 1, regulatory subunit 19V-set and transmembrane domain-containing protein 2B
Modification date2020031320200313
UniProtAcc

O94763

.
Ensembl transtripts involved in fusion geneENST00000574176, ENST00000312051, 
ENST00000360605, ENST00000392271, 
ENST00000542441, 		ENST00000335523, 
Fusion gene scores* DoF score30 X 13 X 12=46809 X 4 X 6=216
# samples 4011
** MAII scorelog2(40/4680*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: URI1 [Title/Abstract] AND VSTM2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointURI1(30477324)-VSTM2B(30054753), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneURI1

GO:0000122

negative regulation of transcription by RNA polymerase II

12737519|15367675|21730289

HgeneURI1

GO:0001558

regulation of cell growth

21730289

HgeneURI1

GO:0071363

cellular response to growth factor stimulus

17936702

HgeneURI1

GO:0071383

cellular response to steroid hormone stimulus

21730289


check buttonFusion gene breakpoints across URI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VSTM2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1348-01AURI1chr19

30477324

+VSTM2Bchr19

30054753

+
ChimerDB4OVTCGA-25-1323-01AURI1chr19

30477324

+VSTM2Bchr19

30054753

+
ChimerDB4OVTCGA-25-1323-01AURI1chr19

30496615

+VSTM2Bchr19

30054753

+


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Fusion Gene ORF analysis for URI1-VSTM2B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000574176ENST00000335523URI1chr19

30496615

+VSTM2Bchr19

30054753

+
In-frameENST00000312051ENST00000335523URI1chr19

30477324

+VSTM2Bchr19

30054753

+
In-frameENST00000312051ENST00000335523URI1chr19

30496615

+VSTM2Bchr19

30054753

+
In-frameENST00000360605ENST00000335523URI1chr19

30477324

+VSTM2Bchr19

30054753

+
In-frameENST00000360605ENST00000335523URI1chr19

30496615

+VSTM2Bchr19

30054753

+
In-frameENST00000392271ENST00000335523URI1chr19

30477324

+VSTM2Bchr19

30054753

+
In-frameENST00000392271ENST00000335523URI1chr19

30496615

+VSTM2Bchr19

30054753

+
In-frameENST00000542441ENST00000335523URI1chr19

30477324

+VSTM2Bchr19

30054753

+
In-frameENST00000542441ENST00000335523URI1chr19

30496615

+VSTM2Bchr19

30054753

+
intron-3CDSENST00000574176ENST00000335523URI1chr19

30477324

+VSTM2Bchr19

30054753

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360605URI1chr1930477324+ENST00000335523VSTM2Bchr1930054753+99536130449139
ENST00000542441URI1chr1930477324+ENST00000335523VSTM2Bchr1930054753+1298664297752151
ENST00000392271URI1chr1930477324+ENST00000335523VSTM2Bchr1930054753+1298664297752151
ENST00000312051URI1chr1930477324+ENST00000335523VSTM2Bchr1930054753+99636210450146
ENST00000360605URI1chr1930496615+ENST00000335523VSTM2Bchr1930054753+114551130599189
ENST00000542441URI1chr1930496615+ENST00000335523VSTM2Bchr1930054753+1448814297902201
ENST00000392271URI1chr1930496615+ENST00000335523VSTM2Bchr1930054753+1448814297902201
ENST00000312051URI1chr1930496615+ENST00000335523VSTM2Bchr1930054753+114651210600196

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360605ENST00000335523URI1chr1930477324+VSTM2Bchr1930054753+0.0424701050.95752984
ENST00000542441ENST00000335523URI1chr1930477324+VSTM2Bchr1930054753+0.0181240760.98187596
ENST00000392271ENST00000335523URI1chr1930477324+VSTM2Bchr1930054753+0.0181240760.98187596
ENST00000312051ENST00000335523URI1chr1930477324+VSTM2Bchr1930054753+0.153043050.84695697
ENST00000360605ENST00000335523URI1chr1930496615+VSTM2Bchr1930054753+0.0016982270.99830174
ENST00000542441ENST00000335523URI1chr1930496615+VSTM2Bchr1930054753+0.0019822030.9980178
ENST00000392271ENST00000335523URI1chr1930496615+VSTM2Bchr1930054753+0.0019822030.9980178
ENST00000312051ENST00000335523URI1chr1930496615+VSTM2Bchr1930054753+0.0033153440.9966846

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Fusion Genomic Features for URI1-VSTM2B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
URI1chr1930496615+VSTM2Bchr1930054752+0.0001537360.9998462
URI1chr1930477324+VSTM2Bchr1930054752+1.77E-060.9999982
URI1chr1930496615+VSTM2Bchr1930054752+0.0001537360.9998462
URI1chr1930477324+VSTM2Bchr1930054752+1.77E-060.9999982

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for URI1-VSTM2B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:30477324/chr19:30054753)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
URI1

O94763

.
FUNCTION: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVSTM2Bchr19:30477324chr19:30054753ENST0000033552335285_285256286.0Topological domainCytoplasmic
TgeneVSTM2Bchr19:30496615chr19:30054753ENST0000033552335285_285256286.0Topological domainCytoplasmic
TgeneVSTM2Bchr19:30477324chr19:30054753ENST0000033552335264_284256286.0TransmembraneHelical
TgeneVSTM2Bchr19:30496615chr19:30054753ENST0000033552335264_284256286.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneURI1chr19:30477324chr19:30054753ENST00000360605+411299_311104476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30477324chr19:30054753ENST00000360605+411314_321104476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30477324chr19:30054753ENST00000392271+411299_31146460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30477324chr19:30054753ENST00000392271+411314_32146460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30477324chr19:30054753ENST00000542441+411299_311122536.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30477324chr19:30054753ENST00000542441+411314_321122536.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30496615chr19:30054753ENST00000360605+611299_311154476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30496615chr19:30054753ENST00000360605+611314_321154476.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30496615chr19:30054753ENST00000392271+611299_31196460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30496615chr19:30054753ENST00000392271+611314_32196460.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30496615chr19:30054753ENST00000542441+611299_311172536.0Compositional biasNote=Poly-Asp
HgeneURI1chr19:30496615chr19:30054753ENST00000542441+611314_321172536.0Compositional biasNote=Poly-Asp
TgeneVSTM2Bchr19:30477324chr19:30054753ENST000003355233529_143256286.0DomainNote=Ig-like V-type
TgeneVSTM2Bchr19:30496615chr19:30054753ENST000003355233529_143256286.0DomainNote=Ig-like V-type
TgeneVSTM2Bchr19:30477324chr19:30054753ENST000003355233529_263256286.0Topological domainExtracellular
TgeneVSTM2Bchr19:30496615chr19:30054753ENST000003355233529_263256286.0Topological domainExtracellular


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Fusion Gene Sequence for URI1-VSTM2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97090_97090_1_URI1-VSTM2B_URI1_chr19_30477324_ENST00000312051_VSTM2B_chr19_30054753_ENST00000335523_length(transcript)=996nt_BP=362nt
ACACGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCT
GCCCTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGAAGAAGGTAGATAATGACTATAATGCCCTTCG
AGAAAGACTCAGCACCTTGCCTGATAAATTGTCTTATAATATAATGGTACCATTTGGCCCTTTTGCCTTCATGCCAGGAAAACTTGTCCA
TACTAATGAAGTCACTGTTTTACTGGGGGACAACTGGTTTGCAAAGTGCTCAGCAAAGCAGGCTGTAGGTTTAGTTGAGCACCGGAAAGA
ACGCACCGGCCGTAGCTACACCACAGACCCACTCTTGTCCCTGCTCCTGTTAGCTCTGCATAAGTTCCTGCGCCTGCTCTTGGGACATTG
ACAGACAAGACCAACCCGAGCATCTCAGAGGCCGCACATGACCTGCCCGGGGCCCTCGGTGAGGACCATGTCGCTGGATGGACACAGAGA
GACTGAGAGACGCATGAAAAAGTCCACATGGAAAATAAATAAATCATATTTTTGGGAAAGTTACACAAATGTAGAACACCTAAAATAATG
CATCTAGTTTCCAAATAATTTGGAGTTTGGCCCATGCAGTCTGCATGGGAATCAATGATTTCTCTACTTCAATGTAGTTTTCTTTTCTAC
ACTTTCCCTCCAAGTCTTCATTTTGCACGAACTGTTGAGCAGTTATCTTTAGGATAATATGTACAAATGTTGGGGTCAAAGCCTTTTGAC
AAAGCAAAATATTTTTAGTAGATTATTGTGTTTAGGATTTTTTTTTAATTTACTTTTTTTCTTTGGGGGCTTTTCTTTTTTATTAAATTA
TTTCTTTTGAGGCATTTTGATTAAAAAAGACACATCTTATCATAATTAAAATTCACTGTCAATAATATTTATTTTTAAATAAAGATTGGA

>97090_97090_1_URI1-VSTM2B_URI1_chr19_30477324_ENST00000312051_VSTM2B_chr19_30054753_ENST00000335523_length(amino acids)=146AA_BP=118
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNE

--------------------------------------------------------------
>97090_97090_2_URI1-VSTM2B_URI1_chr19_30477324_ENST00000360605_VSTM2B_chr19_30054753_ENST00000335523_length(transcript)=995nt_BP=361nt
AGTGGGTCTTCTCACTCTTTTCCAGGCTCCTTGGAGGTCACTGCCCTGATGACAACATGGTCTTCCCTTCAAGGAAGCCACGTTTCTAAG
AGGGCTCTGGCATATGCATTGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGGAAGAAGGTAGATAATGACTATAATGCCCTTCGA
GAAAGACTCAGCACCTTGCCTGATAAATTGTCTTATAATATAATGGTACCATTTGGCCCTTTTGCCTTCATGCCAGGAAAACTTGTCCAT
ACTAATGAAGTCACTGTTTTACTGGGGGACAACTGGTTTGCAAAGTGCTCAGCAAAGCAGGCTGTAGGTTTAGTTGAGCACCGGAAAGAA
CGCACCGGCCGTAGCTACACCACAGACCCACTCTTGTCCCTGCTCCTGTTAGCTCTGCATAAGTTCCTGCGCCTGCTCTTGGGACATTGA
CAGACAAGACCAACCCGAGCATCTCAGAGGCCGCACATGACCTGCCCGGGGCCCTCGGTGAGGACCATGTCGCTGGATGGACACAGAGAG
ACTGAGAGACGCATGAAAAAGTCCACATGGAAAATAAATAAATCATATTTTTGGGAAAGTTACACAAATGTAGAACACCTAAAATAATGC
ATCTAGTTTCCAAATAATTTGGAGTTTGGCCCATGCAGTCTGCATGGGAATCAATGATTTCTCTACTTCAATGTAGTTTTCTTTTCTACA
CTTTCCCTCCAAGTCTTCATTTTGCACGAACTGTTGAGCAGTTATCTTTAGGATAATATGTACAAATGTTGGGGTCAAAGCCTTTTGACA
AAGCAAAATATTTTTAGTAGATTATTGTGTTTAGGATTTTTTTTTAATTTACTTTTTTTCTTTGGGGGCTTTTCTTTTTTATTAAATTAT
TTCTTTTGAGGCATTTTGATTAAAAAAGACACATCTTATCATAATTAAAATTCACTGTCAATAATATTTATTTTTAAATAAAGATTGGAA

>97090_97090_2_URI1-VSTM2B_URI1_chr19_30477324_ENST00000360605_VSTM2B_chr19_30054753_ENST00000335523_length(amino acids)=139AA_BP=111
MEVTALMTTWSSLQGSHVSKRALAYALVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGD

--------------------------------------------------------------
>97090_97090_3_URI1-VSTM2B_URI1_chr19_30477324_ENST00000392271_VSTM2B_chr19_30054753_ENST00000335523_length(transcript)=1298nt_BP=664nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGG
AAGAAGGTAGATAATGACTATAATGCCCTTCGAGAAAGACTCAGCACCTTGCCTGATAAATTGTCTTATAATATAATGGTACCATTTGGC
CCTTTTGCCTTCATGCCAGGAAAACTTGTCCATACTAATGAAGTCACTGTTTTACTGGGGGACAACTGGTTTGCAAAGTGCTCAGCAAAG
CAGGCTGTAGGTTTAGTTGAGCACCGGAAAGAACGCACCGGCCGTAGCTACACCACAGACCCACTCTTGTCCCTGCTCCTGTTAGCTCTG
CATAAGTTCCTGCGCCTGCTCTTGGGACATTGACAGACAAGACCAACCCGAGCATCTCAGAGGCCGCACATGACCTGCCCGGGGCCCTCG
GTGAGGACCATGTCGCTGGATGGACACAGAGAGACTGAGAGACGCATGAAAAAGTCCACATGGAAAATAAATAAATCATATTTTTGGGAA
AGTTACACAAATGTAGAACACCTAAAATAATGCATCTAGTTTCCAAATAATTTGGAGTTTGGCCCATGCAGTCTGCATGGGAATCAATGA
TTTCTCTACTTCAATGTAGTTTTCTTTTCTACACTTTCCCTCCAAGTCTTCATTTTGCACGAACTGTTGAGCAGTTATCTTTAGGATAAT
ATGTACAAATGTTGGGGTCAAAGCCTTTTGACAAAGCAAAATATTTTTAGTAGATTATTGTGTTTAGGATTTTTTTTTAATTTACTTTTT
TTCTTTGGGGGCTTTTCTTTTTTATTAAATTATTTCTTTTGAGGCATTTTGATTAAAAAAGACACATCTTATCATAATTAAAATTCACTG

>97090_97090_3_URI1-VSTM2B_URI1_chr19_30477324_ENST00000392271_VSTM2B_chr19_30054753_ENST00000335523_length(amino acids)=151AA_BP=123
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL

--------------------------------------------------------------
>97090_97090_4_URI1-VSTM2B_URI1_chr19_30477324_ENST00000542441_VSTM2B_chr19_30054753_ENST00000335523_length(transcript)=1298nt_BP=664nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGG
AAGAAGGTAGATAATGACTATAATGCCCTTCGAGAAAGACTCAGCACCTTGCCTGATAAATTGTCTTATAATATAATGGTACCATTTGGC
CCTTTTGCCTTCATGCCAGGAAAACTTGTCCATACTAATGAAGTCACTGTTTTACTGGGGGACAACTGGTTTGCAAAGTGCTCAGCAAAG
CAGGCTGTAGGTTTAGTTGAGCACCGGAAAGAACGCACCGGCCGTAGCTACACCACAGACCCACTCTTGTCCCTGCTCCTGTTAGCTCTG
CATAAGTTCCTGCGCCTGCTCTTGGGACATTGACAGACAAGACCAACCCGAGCATCTCAGAGGCCGCACATGACCTGCCCGGGGCCCTCG
GTGAGGACCATGTCGCTGGATGGACACAGAGAGACTGAGAGACGCATGAAAAAGTCCACATGGAAAATAAATAAATCATATTTTTGGGAA
AGTTACACAAATGTAGAACACCTAAAATAATGCATCTAGTTTCCAAATAATTTGGAGTTTGGCCCATGCAGTCTGCATGGGAATCAATGA
TTTCTCTACTTCAATGTAGTTTTCTTTTCTACACTTTCCCTCCAAGTCTTCATTTTGCACGAACTGTTGAGCAGTTATCTTTAGGATAAT
ATGTACAAATGTTGGGGTCAAAGCCTTTTGACAAAGCAAAATATTTTTAGTAGATTATTGTGTTTAGGATTTTTTTTTAATTTACTTTTT
TTCTTTGGGGGCTTTTCTTTTTTATTAAATTATTTCTTTTGAGGCATTTTGATTAAAAAAGACACATCTTATCATAATTAAAATTCACTG

>97090_97090_4_URI1-VSTM2B_URI1_chr19_30477324_ENST00000542441_VSTM2B_chr19_30054753_ENST00000335523_length(amino acids)=151AA_BP=123
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL

--------------------------------------------------------------
>97090_97090_5_URI1-VSTM2B_URI1_chr19_30496615_ENST00000312051_VSTM2B_chr19_30054753_ENST00000335523_length(transcript)=1146nt_BP=512nt
ACACGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCT
GCCCTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGAAGAAGGTAGATAATGACTATAATGCCCTTCG
AGAAAGACTCAGCACCTTGCCTGATAAATTGTCTTATAATATAATGGTACCATTTGGCCCTTTTGCCTTCATGCCAGGAAAACTTGTCCA
TACTAATGAAGTCACTGTTTTACTGGGGGACAACTGGTTTGCAAAGTGCTCAGCAAAGCAGGCTGTAGGTTTAGTTGAGCACCGGAAAGA
ACATGTAAGAAAAACAATAGATGACTTAAAAAAAGTGATGAAAAATTTTGAATCCAGAGTTGAATTCACAGAAGATTTGCAGAAAATGAG
CGATGCTGCAGGTGATATTGTTGACATACGAGAAGAAATTAAATGTGACTTCGAATTTAAAGGCACCGGCCGTAGCTACACCACAGACCC
ACTCTTGTCCCTGCTCCTGTTAGCTCTGCATAAGTTCCTGCGCCTGCTCTTGGGACATTGACAGACAAGACCAACCCGAGCATCTCAGAG
GCCGCACATGACCTGCCCGGGGCCCTCGGTGAGGACCATGTCGCTGGATGGACACAGAGAGACTGAGAGACGCATGAAAAAGTCCACATG
GAAAATAAATAAATCATATTTTTGGGAAAGTTACACAAATGTAGAACACCTAAAATAATGCATCTAGTTTCCAAATAATTTGGAGTTTGG
CCCATGCAGTCTGCATGGGAATCAATGATTTCTCTACTTCAATGTAGTTTTCTTTTCTACACTTTCCCTCCAAGTCTTCATTTTGCACGA
ACTGTTGAGCAGTTATCTTTAGGATAATATGTACAAATGTTGGGGTCAAAGCCTTTTGACAAAGCAAAATATTTTTAGTAGATTATTGTG
TTTAGGATTTTTTTTTAATTTACTTTTTTTCTTTGGGGGCTTTTCTTTTTTATTAAATTATTTCTTTTGAGGCATTTTGATTAAAAAAGA

>97090_97090_5_URI1-VSTM2B_URI1_chr19_30496615_ENST00000312051_VSTM2B_chr19_30054753_ENST00000335523_length(amino acids)=196AA_BP=167
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNE
VTVLLGDNWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVMKNFESRVEFTEDLQKMSDAAGDIVDIREEIKCDFEFKGTGRSYTTDPLLS

--------------------------------------------------------------
>97090_97090_6_URI1-VSTM2B_URI1_chr19_30496615_ENST00000360605_VSTM2B_chr19_30054753_ENST00000335523_length(transcript)=1145nt_BP=511nt
AGTGGGTCTTCTCACTCTTTTCCAGGCTCCTTGGAGGTCACTGCCCTGATGACAACATGGTCTTCCCTTCAAGGAAGCCACGTTTCTAAG
AGGGCTCTGGCATATGCATTGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGGAAGAAGGTAGATAATGACTATAATGCCCTTCGA
GAAAGACTCAGCACCTTGCCTGATAAATTGTCTTATAATATAATGGTACCATTTGGCCCTTTTGCCTTCATGCCAGGAAAACTTGTCCAT
ACTAATGAAGTCACTGTTTTACTGGGGGACAACTGGTTTGCAAAGTGCTCAGCAAAGCAGGCTGTAGGTTTAGTTGAGCACCGGAAAGAA
CATGTAAGAAAAACAATAGATGACTTAAAAAAAGTGATGAAAAATTTTGAATCCAGAGTTGAATTCACAGAAGATTTGCAGAAAATGAGC
GATGCTGCAGGTGATATTGTTGACATACGAGAAGAAATTAAATGTGACTTCGAATTTAAAGGCACCGGCCGTAGCTACACCACAGACCCA
CTCTTGTCCCTGCTCCTGTTAGCTCTGCATAAGTTCCTGCGCCTGCTCTTGGGACATTGACAGACAAGACCAACCCGAGCATCTCAGAGG
CCGCACATGACCTGCCCGGGGCCCTCGGTGAGGACCATGTCGCTGGATGGACACAGAGAGACTGAGAGACGCATGAAAAAGTCCACATGG
AAAATAAATAAATCATATTTTTGGGAAAGTTACACAAATGTAGAACACCTAAAATAATGCATCTAGTTTCCAAATAATTTGGAGTTTGGC
CCATGCAGTCTGCATGGGAATCAATGATTTCTCTACTTCAATGTAGTTTTCTTTTCTACACTTTCCCTCCAAGTCTTCATTTTGCACGAA
CTGTTGAGCAGTTATCTTTAGGATAATATGTACAAATGTTGGGGTCAAAGCCTTTTGACAAAGCAAAATATTTTTAGTAGATTATTGTGT
TTAGGATTTTTTTTTAATTTACTTTTTTTCTTTGGGGGCTTTTCTTTTTTATTAAATTATTTCTTTTGAGGCATTTTGATTAAAAAAGAC

>97090_97090_6_URI1-VSTM2B_URI1_chr19_30496615_ENST00000360605_VSTM2B_chr19_30054753_ENST00000335523_length(amino acids)=189AA_BP=160
MEVTALMTTWSSLQGSHVSKRALAYALVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGD
NWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVMKNFESRVEFTEDLQKMSDAAGDIVDIREEIKCDFEFKGTGRSYTTDPLLSLLLLALH

--------------------------------------------------------------
>97090_97090_7_URI1-VSTM2B_URI1_chr19_30496615_ENST00000392271_VSTM2B_chr19_30054753_ENST00000335523_length(transcript)=1448nt_BP=814nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGG
AAGAAGGTAGATAATGACTATAATGCCCTTCGAGAAAGACTCAGCACCTTGCCTGATAAATTGTCTTATAATATAATGGTACCATTTGGC
CCTTTTGCCTTCATGCCAGGAAAACTTGTCCATACTAATGAAGTCACTGTTTTACTGGGGGACAACTGGTTTGCAAAGTGCTCAGCAAAG
CAGGCTGTAGGTTTAGTTGAGCACCGGAAAGAACATGTAAGAAAAACAATAGATGACTTAAAAAAAGTGATGAAAAATTTTGAATCCAGA
GTTGAATTCACAGAAGATTTGCAGAAAATGAGCGATGCTGCAGGTGATATTGTTGACATACGAGAAGAAATTAAATGTGACTTCGAATTT
AAAGGCACCGGCCGTAGCTACACCACAGACCCACTCTTGTCCCTGCTCCTGTTAGCTCTGCATAAGTTCCTGCGCCTGCTCTTGGGACAT
TGACAGACAAGACCAACCCGAGCATCTCAGAGGCCGCACATGACCTGCCCGGGGCCCTCGGTGAGGACCATGTCGCTGGATGGACACAGA
GAGACTGAGAGACGCATGAAAAAGTCCACATGGAAAATAAATAAATCATATTTTTGGGAAAGTTACACAAATGTAGAACACCTAAAATAA
TGCATCTAGTTTCCAAATAATTTGGAGTTTGGCCCATGCAGTCTGCATGGGAATCAATGATTTCTCTACTTCAATGTAGTTTTCTTTTCT
ACACTTTCCCTCCAAGTCTTCATTTTGCACGAACTGTTGAGCAGTTATCTTTAGGATAATATGTACAAATGTTGGGGTCAAAGCCTTTTG
ACAAAGCAAAATATTTTTAGTAGATTATTGTGTTTAGGATTTTTTTTTAATTTACTTTTTTTCTTTGGGGGCTTTTCTTTTTTATTAAAT
TATTTCTTTTGAGGCATTTTGATTAAAAAAGACACATCTTATCATAATTAAAATTCACTGTCAATAATATTTATTTTTAAATAAAGATTG

>97090_97090_7_URI1-VSTM2B_URI1_chr19_30496615_ENST00000392271_VSTM2B_chr19_30054753_ENST00000335523_length(amino acids)=201AA_BP=172
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL
VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVMKNFESRVEFTEDLQKMSDAAGDIVDIREEIKCDFEFKGTGRSYTT

--------------------------------------------------------------
>97090_97090_8_URI1-VSTM2B_URI1_chr19_30496615_ENST00000542441_VSTM2B_chr19_30054753_ENST00000335523_length(transcript)=1448nt_BP=814nt
GCGGCCGCCACGCGACGCCTGGCTGGGCCCGCACCGGAGAGGCGTCTCGGTACCTGGCAGGCGGCCTGCTACTCGGAGCCCGCTGCGGGG
CGGCGGCGGCGGGGACATGCACGTGTGAGATGCGGCAGCGGGCGGCGCGGACGCGAACAGCAGCGGCGGCGGCGGGCGCGGCCTCCTGGG
CGCGGGGCGCGCGGTGCCTGAGGGCGGGCGCGCGGGCGCTGGGCAACTGCCGGCCGCGCCGCCTGCGCAGGCGCTGGTTCAGGACTCACA
CGCCGCGCTGAGGCCCGCGGGCCCGTCATGGAGGCGCCCACCGTGGAGACGCCCCCCGACCCCTCGCCCCCTTCGGCCCCGGCCCCTGCC
CTGGTTCCGTTGCGCGCCCCGGATGTGGCGCGGCTGCGCGAGGAGCAGGAAAAGGTGGTCACTAACTGCCAAGAGAGAATCCAGCATTGG
AAGAAGGTAGATAATGACTATAATGCCCTTCGAGAAAGACTCAGCACCTTGCCTGATAAATTGTCTTATAATATAATGGTACCATTTGGC
CCTTTTGCCTTCATGCCAGGAAAACTTGTCCATACTAATGAAGTCACTGTTTTACTGGGGGACAACTGGTTTGCAAAGTGCTCAGCAAAG
CAGGCTGTAGGTTTAGTTGAGCACCGGAAAGAACATGTAAGAAAAACAATAGATGACTTAAAAAAAGTGATGAAAAATTTTGAATCCAGA
GTTGAATTCACAGAAGATTTGCAGAAAATGAGCGATGCTGCAGGTGATATTGTTGACATACGAGAAGAAATTAAATGTGACTTCGAATTT
AAAGGCACCGGCCGTAGCTACACCACAGACCCACTCTTGTCCCTGCTCCTGTTAGCTCTGCATAAGTTCCTGCGCCTGCTCTTGGGACAT
TGACAGACAAGACCAACCCGAGCATCTCAGAGGCCGCACATGACCTGCCCGGGGCCCTCGGTGAGGACCATGTCGCTGGATGGACACAGA
GAGACTGAGAGACGCATGAAAAAGTCCACATGGAAAATAAATAAATCATATTTTTGGGAAAGTTACACAAATGTAGAACACCTAAAATAA
TGCATCTAGTTTCCAAATAATTTGGAGTTTGGCCCATGCAGTCTGCATGGGAATCAATGATTTCTCTACTTCAATGTAGTTTTCTTTTCT
ACACTTTCCCTCCAAGTCTTCATTTTGCACGAACTGTTGAGCAGTTATCTTTAGGATAATATGTACAAATGTTGGGGTCAAAGCCTTTTG
ACAAAGCAAAATATTTTTAGTAGATTATTGTGTTTAGGATTTTTTTTTAATTTACTTTTTTTCTTTGGGGGCTTTTCTTTTTTATTAAAT
TATTTCTTTTGAGGCATTTTGATTAAAAAAGACACATCTTATCATAATTAAAATTCACTGTCAATAATATTTATTTTTAAATAAAGATTG

>97090_97090_8_URI1-VSTM2B_URI1_chr19_30496615_ENST00000542441_VSTM2B_chr19_30054753_ENST00000335523_length(amino acids)=201AA_BP=172
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL
VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVMKNFESRVEFTEDLQKMSDAAGDIVDIREEIKCDFEFKGTGRSYTT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for URI1-VSTM2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for URI1-VSTM2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for URI1-VSTM2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource