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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USB1-CNOT1 (FusionGDB2 ID:97107)

Fusion Gene Summary for USB1-CNOT1

check button Fusion gene summary
Fusion gene informationFusion gene name: USB1-CNOT1
Fusion gene ID: 97107
HgeneTgene
Gene symbol

USB1

CNOT1

Gene ID

79650

23019

Gene nameU6 snRNA biogenesis phosphodiesterase 1CCR4-NOT transcription complex subunit 1
SynonymsC16orf57|HVSL1|Mpn1|PN|hUsb1AD-005|CDC39|HPE12|NOT1|NOT1H
Cytomap

16q21

16q21

Type of geneprotein-codingprotein-coding
DescriptionU6 snRNA phosphodiesteraseHVSL motif containing 1U six biogenesis 1U6 snRNA biogenesis 1UPF0406 protein C16orf57mutated in poikiloderma with neutropenia protein 1putative U6 snRNA phosphodiesteraseCCR4-NOT transcription complex subunit 1CCR4-associated factor 1NOT1 (negative regulator of transcription 1, yeast) homologadrenal gland protein AD-005negative regulator of transcription subunit 1 homolog
Modification date2020032820200322
UniProtAcc

Q9BQ65

Q9UKZ1

Ensembl transtripts involved in fusion geneENST00000565662, ENST00000219281, 
ENST00000423271, ENST00000539737, 
ENST00000561743, ENST00000563149, 
ENST00000317147, ENST00000569240, 
ENST00000245138, ENST00000441024, 
ENST00000569732, 
Fusion gene scores* DoF score6 X 6 X 5=18013 X 11 X 8=1144
# samples 615
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1144*10)=-2.93105264628251
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USB1 [Title/Abstract] AND CNOT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSB1(58044016)-CNOT1(58555221), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCNOT1

GO:0000122

negative regulation of transcription by RNA polymerase II

16778766

TgeneCNOT1

GO:0010606

positive regulation of cytoplasmic mRNA processing body assembly

21976065

TgeneCNOT1

GO:0017148

negative regulation of translation

24736845

TgeneCNOT1

GO:0033147

negative regulation of intracellular estrogen receptor signaling pathway

16778766

TgeneCNOT1

GO:0035195

gene silencing by miRNA

23172285|24768540

TgeneCNOT1

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

16778766

TgeneCNOT1

GO:0060213

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

23644599


check buttonFusion gene breakpoints across USB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNOT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-27-1831-01AUSB1chr16

58044016

+CNOT1chr16

58555221

-


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Fusion Gene ORF analysis for USB1-CNOT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000565662ENST00000317147USB1chr16

58044016

+CNOT1chr16

58555221

-
3UTR-3CDSENST00000565662ENST00000569240USB1chr16

58044016

+CNOT1chr16

58555221

-
3UTR-intronENST00000565662ENST00000245138USB1chr16

58044016

+CNOT1chr16

58555221

-
3UTR-intronENST00000565662ENST00000441024USB1chr16

58044016

+CNOT1chr16

58555221

-
3UTR-intronENST00000565662ENST00000569732USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000219281ENST00000245138USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000219281ENST00000441024USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000219281ENST00000569732USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000423271ENST00000245138USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000423271ENST00000441024USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000423271ENST00000569732USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000539737ENST00000245138USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000539737ENST00000441024USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000539737ENST00000569732USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000561743ENST00000245138USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000561743ENST00000441024USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000561743ENST00000569732USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000563149ENST00000245138USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000563149ENST00000441024USB1chr16

58044016

+CNOT1chr16

58555221

-
5CDS-intronENST00000563149ENST00000569732USB1chr16

58044016

+CNOT1chr16

58555221

-
In-frameENST00000219281ENST00000317147USB1chr16

58044016

+CNOT1chr16

58555221

-
In-frameENST00000219281ENST00000569240USB1chr16

58044016

+CNOT1chr16

58555221

-
In-frameENST00000423271ENST00000317147USB1chr16

58044016

+CNOT1chr16

58555221

-
In-frameENST00000423271ENST00000569240USB1chr16

58044016

+CNOT1chr16

58555221

-
In-frameENST00000539737ENST00000317147USB1chr16

58044016

+CNOT1chr16

58555221

-
In-frameENST00000539737ENST00000569240USB1chr16

58044016

+CNOT1chr16

58555221

-
In-frameENST00000561743ENST00000317147USB1chr16

58044016

+CNOT1chr16

58555221

-
In-frameENST00000561743ENST00000569240USB1chr16

58044016

+CNOT1chr16

58555221

-
In-frameENST00000563149ENST00000317147USB1chr16

58044016

+CNOT1chr16

58555221

-
In-frameENST00000563149ENST00000569240USB1chr16

58044016

+CNOT1chr16

58555221

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000561743USB1chr1658044016+ENST00000317147CNOT1chr1658555221-171048967702211
ENST00000561743USB1chr1658044016+ENST00000569240CNOT1chr1658555221-96648967702211
ENST00000219281USB1chr1658044016+ENST00000317147CNOT1chr1658555221-1781560111773220
ENST00000219281USB1chr1658044016+ENST00000569240CNOT1chr1658555221-1037560111773220
ENST00000539737USB1chr1658044016+ENST00000317147CNOT1chr1658555221-174952879741220
ENST00000539737USB1chr1658044016+ENST00000569240CNOT1chr1658555221-100552879741220
ENST00000423271USB1chr1658044016+ENST00000317147CNOT1chr1658555221-174752677739220
ENST00000423271USB1chr1658044016+ENST00000569240CNOT1chr1658555221-100352677739220
ENST00000563149USB1chr1658044016+ENST00000317147CNOT1chr1658555221-173451364726220
ENST00000563149USB1chr1658044016+ENST00000569240CNOT1chr1658555221-99051364726220

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000561743ENST00000317147USB1chr1658044016+CNOT1chr1658555221-0.221191850.7788082
ENST00000561743ENST00000569240USB1chr1658044016+CNOT1chr1658555221-0.085842960.9141571
ENST00000219281ENST00000317147USB1chr1658044016+CNOT1chr1658555221-0.037016180.96298385
ENST00000219281ENST00000569240USB1chr1658044016+CNOT1chr1658555221-0.0308220370.9691779
ENST00000539737ENST00000317147USB1chr1658044016+CNOT1chr1658555221-0.0289797170.9710202
ENST00000539737ENST00000569240USB1chr1658044016+CNOT1chr1658555221-0.0293593650.9706406
ENST00000423271ENST00000317147USB1chr1658044016+CNOT1chr1658555221-0.026305880.97369415
ENST00000423271ENST00000569240USB1chr1658044016+CNOT1chr1658555221-0.0274698620.9725301
ENST00000563149ENST00000317147USB1chr1658044016+CNOT1chr1658555221-0.0267072250.97329277
ENST00000563149ENST00000569240USB1chr1658044016+CNOT1chr1658555221-0.0277609450.9722391

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Fusion Genomic Features for USB1-CNOT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for USB1-CNOT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:58044016/chr16:58555221)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USB1

Q9BQ65

CNOT1

Q9UKZ1

FUNCTION: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. {ECO:0000255|HAMAP-Rule:MF_03040, ECO:0000269|PubMed:22899009, ECO:0000269|PubMed:23190533}.FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCNOT1chr16:58044016chr16:58555221ENST000004410240311333_135001552.0Compositional biasNote=Thr-rich
TgeneCNOT1chr16:58044016chr16:58555221ENST00000441024031153_15701552.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST000004410240311639_164301552.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST00000441024031181_18501552.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST000004410240311942_194601552.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST000004410240312096_210001552.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST00000441024031223_22701552.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST00000441024031570_57401552.0MotifNote=LXXLL

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCNOT1chr16:58044016chr16:58555221ENST0000031714746491333_135023052377.0Compositional biasNote=Thr-rich
TgeneCNOT1chr16:58044016chr16:58555221ENST0000056924046491333_135023002372.0Compositional biasNote=Thr-rich
TgeneCNOT1chr16:58044016chr16:58555221ENST000003171474649153_15723052377.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST0000031714746491639_164323052377.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST000003171474649181_18523052377.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST0000031714746491942_194623052377.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST0000031714746492096_210023052377.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST000003171474649223_22723052377.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST000003171474649570_57423052377.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST000005692404649153_15723002372.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST0000056924046491639_164323002372.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST000005692404649181_18523002372.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST0000056924046491942_194623002372.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST0000056924046492096_210023002372.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST000005692404649223_22723002372.0MotifNote=LXXLL
TgeneCNOT1chr16:58044016chr16:58555221ENST000005692404649570_57423002372.0MotifNote=LXXLL


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Fusion Gene Sequence for USB1-CNOT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97107_97107_1_USB1-CNOT1_USB1_chr16_58044016_ENST00000219281_CNOT1_chr16_58555221_ENST00000317147_length(transcript)=1781nt_BP=560nt
GCGGTGCCAGCCCAGGCCCCGCCCCTGGGAGGGCGCTTCCGGCACAGCGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCT
GGTGGTCTTGGATGAGGCCCCATGAGCGCGGCGCCCCTGGTGGGCTACAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGG
ACCAGGCCGGGGGATGGGAGCCACCGTCGTGGCCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTC
CCGGGCACCGAGGAGGGGCCTGAAGATGACAGCACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACC
CACGTCTATGTACCATATGAAGCCAAGGAGGAGTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTG
GTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCC
CGTATGACCTCCTTCCACAGAGTTCTCTTGGAACGGTTGATTGTAAATAGGCCACATCCTTGGGGTCTTCTTATTACCTTCATTGAGCTG
ATTAAAAACCCAGCGTTTAAGTTCTGGAACCATGAATTTGTACACTGTGCCCCAGAAATCGAAAAGTTATTCCAGTCGGTCGCACAGTGC
TGCATGGGACAGAAGCAGGCCCAGCAAGTAATGGAAGGGACAGGTGCCAGTTAGACGAAACTGCATCTCTGTTGTACGTGTCAGTCTAGA
GGTCTCACTGCACCGAGTTCATAAACTGACTGAAGAATCCTTTCAGCTCTTCCTGACTTTCCCAGCCCTTTGGTTTGTGGGTATCTGCCC
CAACTACTGTTGGGATCAGCCTCCTGTCTTATGTGGGCACGTTCCAAAGTTTAAATGCATTTTTTTGACTCTTGGCCAAAATTTAGAAGA
TGCTGTGAATATCATTTTGAACTTGTGTAAATACATGAAAGAGAAAACCTTTGTCTGGAACTTCTTGGCTTTGTGCAAGCTGTGTCCAAG
GCAAGTACATAAACTGGTACCTTGTAATGAAGAGGCAGCTGATGCCATGCACTTGTCTGAGGGCATAGCTCCATGTCTTCTGACATTCCT
GGTGTCCCAAAGAATAGCAAAAAGCCAGTTTGAATATTATGTAACTTATTTTTTTAATGTGGACAGGGGACCTTGAAAATCACTAAGTTA
TTAAAAATGTGGATGTGCTAGAATTGGATATGTCCAGGAACATGGGAAGGGCTCACTATTGGAATCCCATGAGTTTCCATTTTGTCTCTA
CCCAAACGTATTCCAAAGCTGACTGCATTTGTACCATCTTATTTCTTTTGGGGATTATACACCTCAGCCGCCTGAGATGGGGGTCAGCTC
TTTATATAAAGGGAAACCAGACCAGGCCTAAAGCCCACCCCTACCCTCACCCCCCCAATCCTCTCCTGAAACTTAAAAACAGTGGGAATA
TAGGAAAGGGAACCAAATCTCATTAATTAATTGTTCTCCCCCATTACCCCACTGAATGAATGGCCATACAGGCTAAGCTGAATAATGACA
AAGTTGAAAGGACCAATACAGCCCCTTTTATAAGGATTTTGAATGTTTTGCAAATGTATTGGTCCCTGTGTTGTATTTTGTAGCCTTTTC

>97107_97107_1_USB1-CNOT1_USB1_chr16_58044016_ENST00000219281_CNOT1_chr16_58555221_ENST00000317147_length(amino acids)=220AA_BP=147
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRVLLERLIVNRPHPWGLLITFIELIKNPAFK

--------------------------------------------------------------
>97107_97107_2_USB1-CNOT1_USB1_chr16_58044016_ENST00000219281_CNOT1_chr16_58555221_ENST00000569240_length(transcript)=1037nt_BP=560nt
GCGGTGCCAGCCCAGGCCCCGCCCCTGGGAGGGCGCTTCCGGCACAGCGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCT
GGTGGTCTTGGATGAGGCCCCATGAGCGCGGCGCCCCTGGTGGGCTACAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGG
ACCAGGCCGGGGGATGGGAGCCACCGTCGTGGCCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTC
CCGGGCACCGAGGAGGGGCCTGAAGATGACAGCACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACC
CACGTCTATGTACCATATGAAGCCAAGGAGGAGTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTG
GTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCC
CGTATGACCTCCTTCCACAGAGTTCTCTTGGAACGGTTGATTGTAAATAGGCCACATCCTTGGGGTCTTCTTATTACCTTCATTGAGCTG
ATTAAAAACCCAGCGTTTAAGTTCTGGAACCATGAATTTGTACACTGTGCCCCAGAAATCGAAAAGTTATTCCAGTCGGTCGCACAGTGC
TGCATGGGACAGAAGCAGGCCCAGCAAGTAATGGAAGGGACAGGTGCCAGTTAGACGAAACTGCATCTCTGTTGTACGTGTCAGTCTAGA
GGTCTCACTGCACCGAGTTCATAAACTGACTGAAGAATCCTTTCAGCTCTTCCTGACTTTCCCAGCCCTTTGGTTTGTGGGTATCTGCCC
CAACTACTGTTGGGATCAGCCTCCTGTCTTATGTGGGCACGTTCCAAAGTTTAAATGCATTTTTTTGACTCTTGGCCAAAATTTAGAAGA

>97107_97107_2_USB1-CNOT1_USB1_chr16_58044016_ENST00000219281_CNOT1_chr16_58555221_ENST00000569240_length(amino acids)=220AA_BP=147
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRVLLERLIVNRPHPWGLLITFIELIKNPAFK

--------------------------------------------------------------
>97107_97107_3_USB1-CNOT1_USB1_chr16_58044016_ENST00000423271_CNOT1_chr16_58555221_ENST00000317147_length(transcript)=1747nt_BP=526nt
GCTTCCGGCACAGCGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCTGGTGGTCTTGGATGAGGCCCCATGAGCGCGGCGC
CCCTGGTGGGCTACAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGGACCAGGCCGGGGGATGGGAGCCACCGTCGTGGCC
AGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAGCA
CAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGAGT
TCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCC
AGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGAGTTCTCTTGGAAC
GGTTGATTGTAAATAGGCCACATCCTTGGGGTCTTCTTATTACCTTCATTGAGCTGATTAAAAACCCAGCGTTTAAGTTCTGGAACCATG
AATTTGTACACTGTGCCCCAGAAATCGAAAAGTTATTCCAGTCGGTCGCACAGTGCTGCATGGGACAGAAGCAGGCCCAGCAAGTAATGG
AAGGGACAGGTGCCAGTTAGACGAAACTGCATCTCTGTTGTACGTGTCAGTCTAGAGGTCTCACTGCACCGAGTTCATAAACTGACTGAA
GAATCCTTTCAGCTCTTCCTGACTTTCCCAGCCCTTTGGTTTGTGGGTATCTGCCCCAACTACTGTTGGGATCAGCCTCCTGTCTTATGT
GGGCACGTTCCAAAGTTTAAATGCATTTTTTTGACTCTTGGCCAAAATTTAGAAGATGCTGTGAATATCATTTTGAACTTGTGTAAATAC
ATGAAAGAGAAAACCTTTGTCTGGAACTTCTTGGCTTTGTGCAAGCTGTGTCCAAGGCAAGTACATAAACTGGTACCTTGTAATGAAGAG
GCAGCTGATGCCATGCACTTGTCTGAGGGCATAGCTCCATGTCTTCTGACATTCCTGGTGTCCCAAAGAATAGCAAAAAGCCAGTTTGAA
TATTATGTAACTTATTTTTTTAATGTGGACAGGGGACCTTGAAAATCACTAAGTTATTAAAAATGTGGATGTGCTAGAATTGGATATGTC
CAGGAACATGGGAAGGGCTCACTATTGGAATCCCATGAGTTTCCATTTTGTCTCTACCCAAACGTATTCCAAAGCTGACTGCATTTGTAC
CATCTTATTTCTTTTGGGGATTATACACCTCAGCCGCCTGAGATGGGGGTCAGCTCTTTATATAAAGGGAAACCAGACCAGGCCTAAAGC
CCACCCCTACCCTCACCCCCCCAATCCTCTCCTGAAACTTAAAAACAGTGGGAATATAGGAAAGGGAACCAAATCTCATTAATTAATTGT
TCTCCCCCATTACCCCACTGAATGAATGGCCATACAGGCTAAGCTGAATAATGACAAAGTTGAAAGGACCAATACAGCCCCTTTTATAAG
GATTTTGAATGTTTTGCAAATGTATTGGTCCCTGTGTTGTATTTTGTAGCCTTTTCCTGGGCTTCAGCTCCCCTACTTCTTGTATGTGTA

>97107_97107_3_USB1-CNOT1_USB1_chr16_58044016_ENST00000423271_CNOT1_chr16_58555221_ENST00000317147_length(amino acids)=220AA_BP=147
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRVLLERLIVNRPHPWGLLITFIELIKNPAFK

--------------------------------------------------------------
>97107_97107_4_USB1-CNOT1_USB1_chr16_58044016_ENST00000423271_CNOT1_chr16_58555221_ENST00000569240_length(transcript)=1003nt_BP=526nt
GCTTCCGGCACAGCGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCTGGTGGTCTTGGATGAGGCCCCATGAGCGCGGCGC
CCCTGGTGGGCTACAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGGACCAGGCCGGGGGATGGGAGCCACCGTCGTGGCC
AGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAGCA
CAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGAGT
TCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCC
AGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGAGTTCTCTTGGAAC
GGTTGATTGTAAATAGGCCACATCCTTGGGGTCTTCTTATTACCTTCATTGAGCTGATTAAAAACCCAGCGTTTAAGTTCTGGAACCATG
AATTTGTACACTGTGCCCCAGAAATCGAAAAGTTATTCCAGTCGGTCGCACAGTGCTGCATGGGACAGAAGCAGGCCCAGCAAGTAATGG
AAGGGACAGGTGCCAGTTAGACGAAACTGCATCTCTGTTGTACGTGTCAGTCTAGAGGTCTCACTGCACCGAGTTCATAAACTGACTGAA
GAATCCTTTCAGCTCTTCCTGACTTTCCCAGCCCTTTGGTTTGTGGGTATCTGCCCCAACTACTGTTGGGATCAGCCTCCTGTCTTATGT
GGGCACGTTCCAAAGTTTAAATGCATTTTTTTGACTCTTGGCCAAAATTTAGAAGATGCTGTGAATATCATTTTGAACTTGTGTAAATAC

>97107_97107_4_USB1-CNOT1_USB1_chr16_58044016_ENST00000423271_CNOT1_chr16_58555221_ENST00000569240_length(amino acids)=220AA_BP=147
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRVLLERLIVNRPHPWGLLITFIELIKNPAFK

--------------------------------------------------------------
>97107_97107_5_USB1-CNOT1_USB1_chr16_58044016_ENST00000539737_CNOT1_chr16_58555221_ENST00000317147_length(transcript)=1749nt_BP=528nt
GCGCTTCCGGCACAGCGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCTGGTGGTCTTGGATGAGGCCCCATGAGCGCGGC
GCCCCTGGTGGGCTACAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGGACCAGGCCGGGGGATGGGAGCCACCGTCGTGG
CCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAG
CACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGA
GTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTC
CCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGAGTTCTCTTGGA
ACGGTTGATTGTAAATAGGCCACATCCTTGGGGTCTTCTTATTACCTTCATTGAGCTGATTAAAAACCCAGCGTTTAAGTTCTGGAACCA
TGAATTTGTACACTGTGCCCCAGAAATCGAAAAGTTATTCCAGTCGGTCGCACAGTGCTGCATGGGACAGAAGCAGGCCCAGCAAGTAAT
GGAAGGGACAGGTGCCAGTTAGACGAAACTGCATCTCTGTTGTACGTGTCAGTCTAGAGGTCTCACTGCACCGAGTTCATAAACTGACTG
AAGAATCCTTTCAGCTCTTCCTGACTTTCCCAGCCCTTTGGTTTGTGGGTATCTGCCCCAACTACTGTTGGGATCAGCCTCCTGTCTTAT
GTGGGCACGTTCCAAAGTTTAAATGCATTTTTTTGACTCTTGGCCAAAATTTAGAAGATGCTGTGAATATCATTTTGAACTTGTGTAAAT
ACATGAAAGAGAAAACCTTTGTCTGGAACTTCTTGGCTTTGTGCAAGCTGTGTCCAAGGCAAGTACATAAACTGGTACCTTGTAATGAAG
AGGCAGCTGATGCCATGCACTTGTCTGAGGGCATAGCTCCATGTCTTCTGACATTCCTGGTGTCCCAAAGAATAGCAAAAAGCCAGTTTG
AATATTATGTAACTTATTTTTTTAATGTGGACAGGGGACCTTGAAAATCACTAAGTTATTAAAAATGTGGATGTGCTAGAATTGGATATG
TCCAGGAACATGGGAAGGGCTCACTATTGGAATCCCATGAGTTTCCATTTTGTCTCTACCCAAACGTATTCCAAAGCTGACTGCATTTGT
ACCATCTTATTTCTTTTGGGGATTATACACCTCAGCCGCCTGAGATGGGGGTCAGCTCTTTATATAAAGGGAAACCAGACCAGGCCTAAA
GCCCACCCCTACCCTCACCCCCCCAATCCTCTCCTGAAACTTAAAAACAGTGGGAATATAGGAAAGGGAACCAAATCTCATTAATTAATT
GTTCTCCCCCATTACCCCACTGAATGAATGGCCATACAGGCTAAGCTGAATAATGACAAAGTTGAAAGGACCAATACAGCCCCTTTTATA
AGGATTTTGAATGTTTTGCAAATGTATTGGTCCCTGTGTTGTATTTTGTAGCCTTTTCCTGGGCTTCAGCTCCCCTACTTCTTGTATGTG

>97107_97107_5_USB1-CNOT1_USB1_chr16_58044016_ENST00000539737_CNOT1_chr16_58555221_ENST00000317147_length(amino acids)=220AA_BP=147
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRVLLERLIVNRPHPWGLLITFIELIKNPAFK

--------------------------------------------------------------
>97107_97107_6_USB1-CNOT1_USB1_chr16_58044016_ENST00000539737_CNOT1_chr16_58555221_ENST00000569240_length(transcript)=1005nt_BP=528nt
GCGCTTCCGGCACAGCGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCTGGTGGTCTTGGATGAGGCCCCATGAGCGCGGC
GCCCCTGGTGGGCTACAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGGACCAGGCCGGGGGATGGGAGCCACCGTCGTGG
CCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAG
CACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGA
GTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTC
CCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGAGTTCTCTTGGA
ACGGTTGATTGTAAATAGGCCACATCCTTGGGGTCTTCTTATTACCTTCATTGAGCTGATTAAAAACCCAGCGTTTAAGTTCTGGAACCA
TGAATTTGTACACTGTGCCCCAGAAATCGAAAAGTTATTCCAGTCGGTCGCACAGTGCTGCATGGGACAGAAGCAGGCCCAGCAAGTAAT
GGAAGGGACAGGTGCCAGTTAGACGAAACTGCATCTCTGTTGTACGTGTCAGTCTAGAGGTCTCACTGCACCGAGTTCATAAACTGACTG
AAGAATCCTTTCAGCTCTTCCTGACTTTCCCAGCCCTTTGGTTTGTGGGTATCTGCCCCAACTACTGTTGGGATCAGCCTCCTGTCTTAT
GTGGGCACGTTCCAAAGTTTAAATGCATTTTTTTGACTCTTGGCCAAAATTTAGAAGATGCTGTGAATATCATTTTGAACTTGTGTAAAT

>97107_97107_6_USB1-CNOT1_USB1_chr16_58044016_ENST00000539737_CNOT1_chr16_58555221_ENST00000569240_length(amino acids)=220AA_BP=147
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRVLLERLIVNRPHPWGLLITFIELIKNPAFK

--------------------------------------------------------------
>97107_97107_7_USB1-CNOT1_USB1_chr16_58044016_ENST00000561743_CNOT1_chr16_58555221_ENST00000317147_length(transcript)=1710nt_BP=489nt
AGATGCAACCCACTTCCAGGTTCCCAGCTCATCTGCCTCTTACATTTAAAAGTTTGTAAGTTTTCTCCTGAGCAGAGGAAGAAGGAAGGA
GAAGCCTTCACAGGACAGTCTGGCCTCTAACTGCTCTGCCAAAGAAATTGGCCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGA
CAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAGCACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGA
GCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGAGTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCA
GACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTT
CGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGAGTTCTCTTGGAACGGTTGATTGTAAATAGGCCACATCCTTGGGGTCTTCT
TATTACCTTCATTGAGCTGATTAAAAACCCAGCGTTTAAGTTCTGGAACCATGAATTTGTACACTGTGCCCCAGAAATCGAAAAGTTATT
CCAGTCGGTCGCACAGTGCTGCATGGGACAGAAGCAGGCCCAGCAAGTAATGGAAGGGACAGGTGCCAGTTAGACGAAACTGCATCTCTG
TTGTACGTGTCAGTCTAGAGGTCTCACTGCACCGAGTTCATAAACTGACTGAAGAATCCTTTCAGCTCTTCCTGACTTTCCCAGCCCTTT
GGTTTGTGGGTATCTGCCCCAACTACTGTTGGGATCAGCCTCCTGTCTTATGTGGGCACGTTCCAAAGTTTAAATGCATTTTTTTGACTC
TTGGCCAAAATTTAGAAGATGCTGTGAATATCATTTTGAACTTGTGTAAATACATGAAAGAGAAAACCTTTGTCTGGAACTTCTTGGCTT
TGTGCAAGCTGTGTCCAAGGCAAGTACATAAACTGGTACCTTGTAATGAAGAGGCAGCTGATGCCATGCACTTGTCTGAGGGCATAGCTC
CATGTCTTCTGACATTCCTGGTGTCCCAAAGAATAGCAAAAAGCCAGTTTGAATATTATGTAACTTATTTTTTTAATGTGGACAGGGGAC
CTTGAAAATCACTAAGTTATTAAAAATGTGGATGTGCTAGAATTGGATATGTCCAGGAACATGGGAAGGGCTCACTATTGGAATCCCATG
AGTTTCCATTTTGTCTCTACCCAAACGTATTCCAAAGCTGACTGCATTTGTACCATCTTATTTCTTTTGGGGATTATACACCTCAGCCGC
CTGAGATGGGGGTCAGCTCTTTATATAAAGGGAAACCAGACCAGGCCTAAAGCCCACCCCTACCCTCACCCCCCCAATCCTCTCCTGAAA
CTTAAAAACAGTGGGAATATAGGAAAGGGAACCAAATCTCATTAATTAATTGTTCTCCCCCATTACCCCACTGAATGAATGGCCATACAG
GCTAAGCTGAATAATGACAAAGTTGAAAGGACCAATACAGCCCCTTTTATAAGGATTTTGAATGTTTTGCAAATGTATTGGTCCCTGTGT
TGTATTTTGTAGCCTTTTCCTGGGCTTCAGCTCCCCTACTTCTTGTATGTGTATGCATACTGTAGCTAACCATTAAAGTCATGACACACA

>97107_97107_7_USB1-CNOT1_USB1_chr16_58044016_ENST00000561743_CNOT1_chr16_58555221_ENST00000317147_length(amino acids)=211AA_BP=138
MSRGRRKEKPSQDSLASNCSAKEIGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYEAKEEFLDLL
DVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHC

--------------------------------------------------------------
>97107_97107_8_USB1-CNOT1_USB1_chr16_58044016_ENST00000561743_CNOT1_chr16_58555221_ENST00000569240_length(transcript)=966nt_BP=489nt
AGATGCAACCCACTTCCAGGTTCCCAGCTCATCTGCCTCTTACATTTAAAAGTTTGTAAGTTTTCTCCTGAGCAGAGGAAGAAGGAAGGA
GAAGCCTTCACAGGACAGTCTGGCCTCTAACTGCTCTGCCAAAGAAATTGGCCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGA
CAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAGCACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGA
GCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGAGTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCA
GACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTT
CGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGAGTTCTCTTGGAACGGTTGATTGTAAATAGGCCACATCCTTGGGGTCTTCT
TATTACCTTCATTGAGCTGATTAAAAACCCAGCGTTTAAGTTCTGGAACCATGAATTTGTACACTGTGCCCCAGAAATCGAAAAGTTATT
CCAGTCGGTCGCACAGTGCTGCATGGGACAGAAGCAGGCCCAGCAAGTAATGGAAGGGACAGGTGCCAGTTAGACGAAACTGCATCTCTG
TTGTACGTGTCAGTCTAGAGGTCTCACTGCACCGAGTTCATAAACTGACTGAAGAATCCTTTCAGCTCTTCCTGACTTTCCCAGCCCTTT
GGTTTGTGGGTATCTGCCCCAACTACTGTTGGGATCAGCCTCCTGTCTTATGTGGGCACGTTCCAAAGTTTAAATGCATTTTTTTGACTC

>97107_97107_8_USB1-CNOT1_USB1_chr16_58044016_ENST00000561743_CNOT1_chr16_58555221_ENST00000569240_length(amino acids)=211AA_BP=138
MSRGRRKEKPSQDSLASNCSAKEIGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYEAKEEFLDLL
DVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHC

--------------------------------------------------------------
>97107_97107_9_USB1-CNOT1_USB1_chr16_58044016_ENST00000563149_CNOT1_chr16_58555221_ENST00000317147_length(transcript)=1734nt_BP=513nt
CGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCTGGTGGTCTTGGATGAGGCCCCATGAGCGCGGCGCCCCTGGTGGGCTA
CAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGGACCAGGCCGGGGGATGGGAGCCACCGTCGTGGCCAGAGCCCCCTTCC
CAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAGCACAAAACACGGGGG
ACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGAGTTCCTGGATCTGCT
TGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCCAGAGTGTGGTTCT
GCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGAGTTCTCTTGGAACGGTTGATTGTAAA
TAGGCCACATCCTTGGGGTCTTCTTATTACCTTCATTGAGCTGATTAAAAACCCAGCGTTTAAGTTCTGGAACCATGAATTTGTACACTG
TGCCCCAGAAATCGAAAAGTTATTCCAGTCGGTCGCACAGTGCTGCATGGGACAGAAGCAGGCCCAGCAAGTAATGGAAGGGACAGGTGC
CAGTTAGACGAAACTGCATCTCTGTTGTACGTGTCAGTCTAGAGGTCTCACTGCACCGAGTTCATAAACTGACTGAAGAATCCTTTCAGC
TCTTCCTGACTTTCCCAGCCCTTTGGTTTGTGGGTATCTGCCCCAACTACTGTTGGGATCAGCCTCCTGTCTTATGTGGGCACGTTCCAA
AGTTTAAATGCATTTTTTTGACTCTTGGCCAAAATTTAGAAGATGCTGTGAATATCATTTTGAACTTGTGTAAATACATGAAAGAGAAAA
CCTTTGTCTGGAACTTCTTGGCTTTGTGCAAGCTGTGTCCAAGGCAAGTACATAAACTGGTACCTTGTAATGAAGAGGCAGCTGATGCCA
TGCACTTGTCTGAGGGCATAGCTCCATGTCTTCTGACATTCCTGGTGTCCCAAAGAATAGCAAAAAGCCAGTTTGAATATTATGTAACTT
ATTTTTTTAATGTGGACAGGGGACCTTGAAAATCACTAAGTTATTAAAAATGTGGATGTGCTAGAATTGGATATGTCCAGGAACATGGGA
AGGGCTCACTATTGGAATCCCATGAGTTTCCATTTTGTCTCTACCCAAACGTATTCCAAAGCTGACTGCATTTGTACCATCTTATTTCTT
TTGGGGATTATACACCTCAGCCGCCTGAGATGGGGGTCAGCTCTTTATATAAAGGGAAACCAGACCAGGCCTAAAGCCCACCCCTACCCT
CACCCCCCCAATCCTCTCCTGAAACTTAAAAACAGTGGGAATATAGGAAAGGGAACCAAATCTCATTAATTAATTGTTCTCCCCCATTAC
CCCACTGAATGAATGGCCATACAGGCTAAGCTGAATAATGACAAAGTTGAAAGGACCAATACAGCCCCTTTTATAAGGATTTTGAATGTT
TTGCAAATGTATTGGTCCCTGTGTTGTATTTTGTAGCCTTTTCCTGGGCTTCAGCTCCCCTACTTCTTGTATGTGTATGCATACTGTAGC

>97107_97107_9_USB1-CNOT1_USB1_chr16_58044016_ENST00000563149_CNOT1_chr16_58555221_ENST00000317147_length(amino acids)=220AA_BP=147
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRVLLERLIVNRPHPWGLLITFIELIKNPAFK

--------------------------------------------------------------
>97107_97107_10_USB1-CNOT1_USB1_chr16_58044016_ENST00000563149_CNOT1_chr16_58555221_ENST00000569240_length(transcript)=990nt_BP=513nt
CGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCTGGTGGTCTTGGATGAGGCCCCATGAGCGCGGCGCCCCTGGTGGGCTA
CAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGGACCAGGCCGGGGGATGGGAGCCACCGTCGTGGCCAGAGCCCCCTTCC
CAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAGCACAAAACACGGGGG
ACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGAGTTCCTGGATCTGCT
TGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCCAGAGTGTGGTTCT
GCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGAGTTCTCTTGGAACGGTTGATTGTAAA
TAGGCCACATCCTTGGGGTCTTCTTATTACCTTCATTGAGCTGATTAAAAACCCAGCGTTTAAGTTCTGGAACCATGAATTTGTACACTG
TGCCCCAGAAATCGAAAAGTTATTCCAGTCGGTCGCACAGTGCTGCATGGGACAGAAGCAGGCCCAGCAAGTAATGGAAGGGACAGGTGC
CAGTTAGACGAAACTGCATCTCTGTTGTACGTGTCAGTCTAGAGGTCTCACTGCACCGAGTTCATAAACTGACTGAAGAATCCTTTCAGC
TCTTCCTGACTTTCCCAGCCCTTTGGTTTGTGGGTATCTGCCCCAACTACTGTTGGGATCAGCCTCCTGTCTTATGTGGGCACGTTCCAA
AGTTTAAATGCATTTTTTTGACTCTTGGCCAAAATTTAGAAGATGCTGTGAATATCATTTTGAACTTGTGTAAATACATGAAAGAGAAAA

>97107_97107_10_USB1-CNOT1_USB1_chr16_58044016_ENST00000563149_CNOT1_chr16_58555221_ENST00000569240_length(amino acids)=220AA_BP=147
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRVLLERLIVNRPHPWGLLITFIELIKNPAFK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USB1-CNOT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCNOT1chr16:58044016chr16:58555221ENST000004410240311090_160501552.0CNOT6%2C CNOT6L%2C CNOT7 and CNOT8
TgeneCNOT1chr16:58044016chr16:58555221ENST00000441024031800_101501552.0ZFP36


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCNOT1chr16:58044016chr16:58555221ENST0000031714746491090_16052305.66666666666652377.0CNOT6%2C CNOT6L%2C CNOT7 and CNOT8
TgeneCNOT1chr16:58044016chr16:58555221ENST0000056924046491090_16052300.66666666666652372.0CNOT6%2C CNOT6L%2C CNOT7 and CNOT8
TgeneCNOT1chr16:58044016chr16:58555221ENST000003171474649800_10152305.66666666666652377.0ZFP36
TgeneCNOT1chr16:58044016chr16:58555221ENST000005692404649800_10152300.66666666666652372.0ZFP36


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USB1-CNOT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USB1-CNOT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource