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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:USB1-MAPKAPK5 (FusionGDB2 ID:97110)

Fusion Gene Summary for USB1-MAPKAPK5

check button Fusion gene summary
Fusion gene informationFusion gene name: USB1-MAPKAPK5
Fusion gene ID: 97110
HgeneTgene
Gene symbol

USB1

MAPKAPK5

Gene ID

79650

8550

Gene nameU6 snRNA biogenesis phosphodiesterase 1MAPK activated protein kinase 5
SynonymsC16orf57|HVSL1|Mpn1|PN|hUsb1MAPKAP-K5|MK-5|MK5|PRAK
Cytomap

16q21

12q24.12-q24.13

Type of geneprotein-codingprotein-coding
DescriptionU6 snRNA phosphodiesteraseHVSL motif containing 1U six biogenesis 1U6 snRNA biogenesis 1UPF0406 protein C16orf57mutated in poikiloderma with neutropenia protein 1putative U6 snRNA phosphodiesteraseMAP kinase-activated protein kinase 5MAPKAP kinase 5MAPKAPK-5mitogen-activated protein kinase-activated protein kinase 5p38-regulated/activated protein kinase
Modification date2020032820200313
UniProtAcc

Q9BQ65

Q8IW41

Ensembl transtripts involved in fusion geneENST00000565662, ENST00000219281, 
ENST00000539737, ENST00000561743, 
ENST00000423271, ENST00000563149, 
ENST00000550735, ENST00000551404, 
ENST00000546394, ENST00000547305, 
Fusion gene scores* DoF score6 X 6 X 5=1808 X 10 X 3=240
# samples 611
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/240*10)=-1.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: USB1 [Title/Abstract] AND MAPKAPK5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointUSB1(58051343)-MAPKAPK5(112308889), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAPKAPK5

GO:0006417

regulation of translation

21329882

TgeneMAPKAPK5

GO:0007265

Ras protein signal transduction

17254968

TgeneMAPKAPK5

GO:0046777

protein autophosphorylation

21329882

TgeneMAPKAPK5

GO:0090400

stress-induced premature senescence

17254968


check buttonFusion gene breakpoints across USB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAPKAPK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2262-01AUSB1chr16

58051343

+MAPKAPK5chr12

112308889

+


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Fusion Gene ORF analysis for USB1-MAPKAPK5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000565662ENST00000550735USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
3UTR-3CDSENST00000565662ENST00000551404USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
3UTR-intronENST00000565662ENST00000546394USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
3UTR-intronENST00000565662ENST00000547305USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
5CDS-intronENST00000219281ENST00000546394USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
5CDS-intronENST00000219281ENST00000547305USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
5CDS-intronENST00000539737ENST00000546394USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
5CDS-intronENST00000539737ENST00000547305USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
5CDS-intronENST00000561743ENST00000546394USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
5CDS-intronENST00000561743ENST00000547305USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
In-frameENST00000219281ENST00000550735USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
In-frameENST00000219281ENST00000551404USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
In-frameENST00000539737ENST00000550735USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
In-frameENST00000539737ENST00000551404USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
In-frameENST00000561743ENST00000550735USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
In-frameENST00000561743ENST00000551404USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
intron-3CDSENST00000423271ENST00000550735USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
intron-3CDSENST00000423271ENST00000551404USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
intron-3CDSENST00000563149ENST00000550735USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
intron-3CDSENST00000563149ENST00000551404USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
intron-intronENST00000423271ENST00000546394USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
intron-intronENST00000423271ENST00000547305USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
intron-intronENST00000563149ENST00000546394USB1chr16

58051343

+MAPKAPK5chr12

112308889

+
intron-intronENST00000563149ENST00000547305USB1chr16

58051343

+MAPKAPK5chr12

112308889

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000561743USB1chr1658051343+ENST00000550735MAPKAPK5chr12112308889+1937649671581504
ENST00000561743USB1chr1658051343+ENST00000551404MAPKAPK5chr12112308889+1688649671587506
ENST00000219281USB1chr1658051343+ENST00000550735MAPKAPK5chr12112308889+20087201111652513
ENST00000219281USB1chr1658051343+ENST00000551404MAPKAPK5chr12112308889+17597201111658515
ENST00000539737USB1chr1658051343+ENST00000550735MAPKAPK5chr12112308889+1922634791566495
ENST00000539737USB1chr1658051343+ENST00000551404MAPKAPK5chr12112308889+1673634791572497

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000561743ENST00000550735USB1chr1658051343+MAPKAPK5chr12112308889+0.0008474190.99915254
ENST00000561743ENST00000551404USB1chr1658051343+MAPKAPK5chr12112308889+0.0011602930.9988397
ENST00000219281ENST00000550735USB1chr1658051343+MAPKAPK5chr12112308889+0.0007451370.9992549
ENST00000219281ENST00000551404USB1chr1658051343+MAPKAPK5chr12112308889+0.0009895090.99901044
ENST00000539737ENST00000550735USB1chr1658051343+MAPKAPK5chr12112308889+0.0010927290.9989072
ENST00000539737ENST00000551404USB1chr1658051343+MAPKAPK5chr12112308889+0.0014604880.99853957

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Fusion Genomic Features for USB1-MAPKAPK5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
USB1chr1658051343+MAPKAPK5chr12112308888+4.34E-050.9999566
USB1chr1658051343+MAPKAPK5chr12112308888+4.34E-050.9999566

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for USB1-MAPKAPK5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:58051343/chr12:112308889)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
USB1

Q9BQ65

MAPKAPK5

Q8IW41

FUNCTION: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. {ECO:0000255|HAMAP-Rule:MF_03040, ECO:0000269|PubMed:22899009, ECO:0000269|PubMed:23190533}.FUNCTION: Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAPKAPK5chr16:58051343chr12:112308889ENST00000550735514409_440161472.0Coiled coilOntology_term=ECO:0000255
TgeneMAPKAPK5chr16:58051343chr12:112308889ENST00000551404514409_440161474.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAPKAPK5chr16:58051343chr12:112308889ENST0000055073551422_304161472.0DomainProtein kinase
TgeneMAPKAPK5chr16:58051343chr12:112308889ENST0000055140451422_304161474.0DomainProtein kinase
TgeneMAPKAPK5chr16:58051343chr12:112308889ENST0000055073551428_36161472.0Nucleotide bindingATP
TgeneMAPKAPK5chr16:58051343chr12:112308889ENST0000055140451428_36161474.0Nucleotide bindingATP


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Fusion Gene Sequence for USB1-MAPKAPK5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>97110_97110_1_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000219281_MAPKAPK5_chr12_112308889_ENST00000550735_length(transcript)=2008nt_BP=720nt
GCGGTGCCAGCCCAGGCCCCGCCCCTGGGAGGGCGCTTCCGGCACAGCGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCT
GGTGGTCTTGGATGAGGCCCCATGAGCGCGGCGCCCCTGGTGGGCTACAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGG
ACCAGGCCGGGGGATGGGAGCCACCGTCGTGGCCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTC
CCGGGCACCGAGGAGGGGCCTGAAGATGACAGCACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACC
CACGTCTATGTACCATATGAAGCCAAGGAGGAGTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTG
GTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCC
CGTATGACCTCCTTCCACAGATTCTTCTTTACTGCCAACCAGGTAAAGATTTACACCAATCAAGAGAAAACCAGGACCTTTATTGGGCTT
GAGGTCACTTCAGGGCATGCCCAGTTCCTGGACCTGGTTTCAGAGGTGGACAGAGTCATGGAGGAATTCAACCTCACCACTTTCTACCAG
GATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTATGTAGCA
CCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAACAAGAGC
TGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACTATCCCA
AAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGATGTTGTG
AGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCCCTGGAT
AATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAACATGAGA
ATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAGCCAAAG
GACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAGTGTATT
CTCCCCCAGGCTGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAAACTCCTAAGA
GATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAAGCAGGTGATA
GAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCAGACTTTGTTTTTTTAACAATTTGAAAAATTATTCTTTAATGTATAA
AGTAATTTTATGTAAATTAATAAATCATAATTTCATTTCCACATTGATTAAAGCTGCTGTATAGATTTAGGGTGCAGGACTTAATAATAG
TATAGTTATTGTTTGTTTTTAAGAAAAGCTCAGTTCTAGAGACATACTATTACTTTAGGACTGTGTAGTTGTATATTTGTAAGATGACAG
ATGATGCTGTCAAGCAATATTGTTTTATTTGTAATAAAATATACAAAAATCACTTGCCAGCAGTAGAAAAAGGACCGACTATACCGACCT

>97110_97110_1_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000219281_MAPKAPK5_chr12_112308889_ENST00000550735_length(amino acids)=513AA_BP=202
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRFFFTANQVKIYTNQEKTRTFIGLEVTSGHA
QFLDLVSEVDRVMEEFNLTTFYQDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLG
VIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQ
LMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGEN

--------------------------------------------------------------
>97110_97110_2_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000219281_MAPKAPK5_chr12_112308889_ENST00000551404_length(transcript)=1759nt_BP=720nt
GCGGTGCCAGCCCAGGCCCCGCCCCTGGGAGGGCGCTTCCGGCACAGCGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCT
GGTGGTCTTGGATGAGGCCCCATGAGCGCGGCGCCCCTGGTGGGCTACAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGG
ACCAGGCCGGGGGATGGGAGCCACCGTCGTGGCCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTC
CCGGGCACCGAGGAGGGGCCTGAAGATGACAGCACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACC
CACGTCTATGTACCATATGAAGCCAAGGAGGAGTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTG
GTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCC
CGTATGACCTCCTTCCACAGATTCTTCTTTACTGCCAACCAGGTAAAGATTTACACCAATCAAGAGAAAACCAGGACCTTTATTGGGCTT
GAGGTCACTTCAGGGCATGCCCAGTTCCTGGACCTGGTTTCAGAGGTGGACAGAGTCATGGAGGAATTCAACCTCACCACTTTCTACCAG
GATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTATGTAGCA
CCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAACAAGAGC
TGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACTATCCCA
AAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGATGTTGTG
AGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCCCTGGAT
AATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAACATGAGA
ATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAGCCAAAG
GACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAGTGTATT
CTCCCCCAGGCTGGTAAAGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAAACTC
CTAAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAAGCAG
GTGATAGAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCAGACTTTGTTTTTTTAACAATTTGAAAAATTATTCTTTAAT

>97110_97110_2_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000219281_MAPKAPK5_chr12_112308889_ENST00000551404_length(amino acids)=515AA_BP=202
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRFFFTANQVKIYTNQEKTRTFIGLEVTSGHA
QFLDLVSEVDRVMEEFNLTTFYQDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLG
VIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQ
LMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKG

--------------------------------------------------------------
>97110_97110_3_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000539737_MAPKAPK5_chr12_112308889_ENST00000550735_length(transcript)=1922nt_BP=634nt
GCGCTTCCGGCACAGCGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCTGGTGGTCTTGGATGAGGCCCCATGAGCGCGGC
GCCCCTGGTGGGCTACAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGGACCAGGCCGGGGGATGGGAGCCACCGTCGTGG
CCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAG
CACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGA
GTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTC
CCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGGACCTTTATTGG
GCTTGAGGTCACTTCAGGGCATGCCCAGTTCCTGGACCTGGTTTCAGAGGTGGACAGAGTCATGGAGGAATTCAACCTCACCACTTTCTA
CCAGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTATGT
AGCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAACAA
GAGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACTAT
CCCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGATGT
TGTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCCCT
GGATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAACAT
GAGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAGCC
AAAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAGTG
TATTCTCCCCCAGGCTGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAAACTCCT
AAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAAGCAGGT
GATAGAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCAGACTTTGTTTTTTTAACAATTTGAAAAATTATTCTTTAATGT
ATAAAGTAATTTTATGTAAATTAATAAATCATAATTTCATTTCCACATTGATTAAAGCTGCTGTATAGATTTAGGGTGCAGGACTTAATA
ATAGTATAGTTATTGTTTGTTTTTAAGAAAAGCTCAGTTCTAGAGACATACTATTACTTTAGGACTGTGTAGTTGTATATTTGTAAGATG
ACAGATGATGCTGTCAAGCAATATTGTTTTATTTGTAATAAAATATACAAAAATCACTTGCCAGCAGTAGAAAAAGGACCGACTATACCG

>97110_97110_3_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000539737_MAPKAPK5_chr12_112308889_ENST00000550735_length(amino acids)=495AA_BP=184
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRTFIGLEVTSGHAQFLDLVSEVDRVMEEFNL
TTFYQDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHH
SRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQ
LANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEAWKYNRE

--------------------------------------------------------------
>97110_97110_4_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000539737_MAPKAPK5_chr12_112308889_ENST00000551404_length(transcript)=1673nt_BP=634nt
GCGCTTCCGGCACAGCGGAACTCCGGGTGCCGGTTGAGGTTGCTGGTGGACCTGCTCTGGTGGTCTTGGATGAGGCCCCATGAGCGCGGC
GCCCCTGGTGGGCTACAGCAGCAGCGGCTCCGAGGATGAGTCCGAGGACGGGATGCGGACCAGGCCGGGGGATGGGAGCCACCGTCGTGG
CCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGACAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAG
CACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGAGCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGA
GTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCAGACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTC
CCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTTCGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGGACCTTTATTGG
GCTTGAGGTCACTTCAGGGCATGCCCAGTTCCTGGACCTGGTTTCAGAGGTGGACAGAGTCATGGAGGAATTCAACCTCACCACTTTCTA
CCAGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTATGT
AGCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTACACTTACAACAA
GAGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACTAT
CCCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGATGGCCAAAGATGT
TGTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCCCT
GGATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACAGTTGGCCAACAT
GAGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAGCC
AAAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGTGATTGCTCAGTG
TATTCTCCCCCAGGCTGGTAAAGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAA
ACTCCTAAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAATTGTGAA
GCAGGTGATAGAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCAGACTTTGTTTTTTTAACAATTTGAAAAATTATTCTT

>97110_97110_4_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000539737_MAPKAPK5_chr12_112308889_ENST00000551404_length(amino acids)=497AA_BP=184
MSAAPLVGYSSSGSEDESEDGMRTRPGDGSHRRGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYE
AKEEFLDLLDVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRTFIGLEVTSGHAQFLDLVSEVDRVMEEFNL
TTFYQDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHH
SRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQ
LANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQEAWKYN

--------------------------------------------------------------
>97110_97110_5_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000561743_MAPKAPK5_chr12_112308889_ENST00000550735_length(transcript)=1937nt_BP=649nt
AGATGCAACCCACTTCCAGGTTCCCAGCTCATCTGCCTCTTACATTTAAAAGTTTGTAAGTTTTCTCCTGAGCAGAGGAAGAAGGAAGGA
GAAGCCTTCACAGGACAGTCTGGCCTCTAACTGCTCTGCCAAAGAAATTGGCCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGA
CAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAGCACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGA
GCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGAGTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCA
GACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTT
CGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGATTCTTCTTTACTGCCAACCAGGTAAAGATTTACACCAATCAAGAGAAAAC
CAGGACCTTTATTGGGCTTGAGGTCACTTCAGGGCATGCCCAGTTCCTGGACCTGGTTTCAGAGGTGGACAGAGTCATGGAGGAATTCAA
CCTCACCACTTTCTACCAGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTT
CACCCCTTATTATGTAGCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCC
CTACACTTACAACAAGAGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACA
CCACAGCCGGACTATCCCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGA
GATGGCCAAAGATGTTGTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAA
TTCCACCGAGGCCCTGGATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGA
ACAGTTGGCCAACATGAGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTT
ACTTGGCACCAAGCCAAAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGA
TGTGATTGCTCAGTGTATTCTCCCCCAGGCTGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTATAACCG
GGAATGCAAACTCCTAAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGA
AATTGTGAAGCAGGTGATAGAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCAGACTTTGTTTTTTTAACAATTTGAAAA
ATTATTCTTTAATGTATAAAGTAATTTTATGTAAATTAATAAATCATAATTTCATTTCCACATTGATTAAAGCTGCTGTATAGATTTAGG
GTGCAGGACTTAATAATAGTATAGTTATTGTTTGTTTTTAAGAAAAGCTCAGTTCTAGAGACATACTATTACTTTAGGACTGTGTAGTTG
TATATTTGTAAGATGACAGATGATGCTGTCAAGCAATATTGTTTTATTTGTAATAAAATATACAAAAATCACTTGCCAGCAGTAGAAAAA

>97110_97110_5_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000561743_MAPKAPK5_chr12_112308889_ENST00000550735_length(amino acids)=504AA_BP=193
MSRGRRKEKPSQDSLASNCSAKEIGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYEAKEEFLDLL
DVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRFFFTANQVKIYTNQEKTRTFIGLEVTSGHAQFLDLVSEV
DRVMEEFNLTTFYQDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCG
YPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVA
GIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVM

--------------------------------------------------------------
>97110_97110_6_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000561743_MAPKAPK5_chr12_112308889_ENST00000551404_length(transcript)=1688nt_BP=649nt
AGATGCAACCCACTTCCAGGTTCCCAGCTCATCTGCCTCTTACATTTAAAAGTTTGTAAGTTTTCTCCTGAGCAGAGGAAGAAGGAAGGA
GAAGCCTTCACAGGACAGTCTGGCCTCTAACTGCTCTGCCAAAGAAATTGGCCAGAGCCCCCTTCCCAGGCAGAGATTTCCAGTACCTGA
CAGTGTGCTGAACATGTTCCCGGGCACCGAGGAGGGGCCTGAAGATGACAGCACAAAACACGGGGGACGGGTGCGCACCTTCCCCCACGA
GCGAGGCAACTGGGCCACCCACGTCTATGTACCATATGAAGCCAAGGAGGAGTTCCTGGATCTGCTTGATGTGTTGCTGCCCCATGCCCA
GACATATGTCCCCCGGCTGGTAAGGATGAAGGTGTTCCACCTCAGCCTGTCCCAGAGTGTGGTTCTGCGCCACCACTGGATCCTCCCCTT
CGTGCAGGCTCTGAAAGCCCGTATGACCTCCTTCCACAGATTCTTCTTTACTGCCAACCAGGTAAAGATTTACACCAATCAAGAGAAAAC
CAGGACCTTTATTGGGCTTGAGGTCACTTCAGGGCATGCCCAGTTCCTGGACCTGGTTTCAGAGGTGGACAGAGTCATGGAGGAATTCAA
CCTCACCACTTTCTACCAGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGACCAAGGTGACTTGATGACACCCCAGTT
CACCCCTTATTATGTAGCACCCCAGGTACTGGAGGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCC
CTACACTTACAACAAGAGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTGCGGATACCCTCCTTTTTACTCCAAACA
CCACAGCCGGACTATCCCAAAGGATATGCGAAGAAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGA
GATGGCCAAAGATGTTGTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGAGGGAGTGCTGGACCACCCCTGGCTCAA
TTCCACCGAGGCCCTGGATAATGTGCTGCCTTCTGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGA
ACAGTTGGCCAACATGAGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAACAACCCCATTCTGCGGAAGAGGAAGTT
ACTTGGCACCAAGCCAAAGGACAGTGTCTATATCCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGA
TGTGATTGCTCAGTGTATTCTCCCCCAGGCTGGTAAAGGAGAGAATGAAGATGAGAAACTGAATGAAGTAATGCAGGAGGCTTGGAAGTA
TAACCGGGAATGCAAACTCCTAAGAGATACTCTGCAGAGCTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACT
GGCAGAAATTGTGAAGCAGGTGATAGAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCAGACTTTGTTTTTTTAACAATT

>97110_97110_6_USB1-MAPKAPK5_USB1_chr16_58051343_ENST00000561743_MAPKAPK5_chr12_112308889_ENST00000551404_length(amino acids)=506AA_BP=193
MSRGRRKEKPSQDSLASNCSAKEIGQSPLPRQRFPVPDSVLNMFPGTEEGPEDDSTKHGGRVRTFPHERGNWATHVYVPYEAKEEFLDLL
DVLLPHAQTYVPRLVRMKVFHLSLSQSVVLRHHWILPFVQALKARMTSFHRFFFTANQVKIYTNQEKTRTFIGLEVTSGHAQFLDLVSEV
DRVMEEFNLTTFYQDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCG
YPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVA
GIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for USB1-MAPKAPK5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for USB1-MAPKAPK5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for USB1-MAPKAPK5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource